INTERNATIONAL CONFERENCE ON INTEGRATIVE AND MODERN MEDICINE

Amrita Institute of Medical Sciences, August 6 and 7, 2017

BOOK OF ABSTRACTS

Organised by Amrita Centre for Advanced Research in Ayurveda Amrita Centre for Integrated Medicine Amrita School of Ayurveda Amrita Institute of Medical Sciences Amrita Centre for Nano Sciences and Molecular Medicine

Organised by

Amrita Centre for Advanced Research in Ayurveda Centre for Integrated Medicine and Research Amrita School of Ayurveda Amrita Institute of Medical Sciences Amrita Centre for Nano Sciences and Molecular Medicine

Platinum Sponsor

Silver Sponsors

Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Book of Abstracts 2 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Book of Abstracts of the 2017 International Research Conference on Integrative Ayurveda and Modern Medicine

6 and 7 of August, 2017 Amrita Institute of Medical Sciences, Kochi, ,

Abstracts presented at the 2017 International Research Conference on Integrative Ayurveda and Modern Medicine - Amrita Samyogam - will be archived after further peer review as an online supplement in Journal of Ayurveda and Integrative Medicine, the only Scopus indexed research journal in the field of Ayurveda published by Elsevier. The supplement will be open access and can be viewed at https:// www.journals.elsevier.com/journal-of-ayurveda-and-integrative-medicine/ at a later date. Book of Abstracts 3 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Book of Abstracts 4 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Contents

Committees 7 Message from the Chancellor 9 Schedule at a Glance 11 Inaugural Session 13 Valedictory Session 14 Conference Schedule 15 Distinguished Guests 27 Invited Speakers 30 Abstracts of Invited Talks 39 Abstracts of Oral Presentations 61 Abstracts of Poster Presentations 89

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Book of Abstracts 6 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Committees

Honorary Chair Finance: Bri Shuddhamrita Mata Amritanandamayi Devi, Chancellor, Amrita University Transport: Dr Vineeth PK

General Chairs Food Chair: Dr James Chacko Dr Venkat Rangan, Vice Chancellor, Amrita University Sponsorship: Dr NV Ramesh Swami Amritaswarupananda Puri, Vice President, MA Math Exhibition: Dr Anandaram PV, Dr Shivabalaji Swami Poornamirtananda Puri, General Secretary, MA Math Program Management: Dr Priya S, Dr Priyalatha, Program Chairs Dr Vimala KS, Dr Daniel Furst Dr Raiby P Paul Br Sankara Chaitanya Dr Shantikumar V Nair Event Management: Bri Abhirami

Steering Committee Conference Secretariat: Dr (Bri) Sushma, Dr Vijayakumar Dr Rajalakshmi, Dr Prem Nair Mr Lalkrishnan Dr Bipin Nair Dr Ram Manohar Scientific Review Committee Dr Shyam Diwakar Dr Milind Patil Dr Narendra Bhatt Organising Committee Dr Anand Chaudhary Dr Supriya Bhalerao Organising Chair: Dr Shantikumar V Nair Dr Pawankumar Godatwar Dr Pooja Sabharwal Organising Co-Chair: Dr M Vijayakumar Dr Rajmohan Dr MR Vasudevan Nampoothiri Dr Kishor Patwardhan General Secretary: Dr Ram Manohar Dr Asoke Banerjee Dr Shyam Diwakar Conference Proceedings: Dr Rabinarayan Tripathy, Dr Sanjeev Rastogi Dr Sharath SG Dr. Krishnakumar Menon Dr. Jayakumar Conference Publicity: Dr Anandaram PV Dr. Anupama Kizhakkeveettil Dr. P. Ram Manohar Guest and Accommodation: Dr Delvin T Robin, Dr. Rabinarayan Tripathy Dr Arun Mohan Dr. Girish Tillu

Book of Abstracts 7 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Book of Abstracts 8 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Message from the Chancellor

The goal of science has always been knowledge – an understanding of the human body and the universe as a whole. With no doubt, the knowledge gained from scientific research and development has helped to make our external life more comfortable and affluent. Regardless, happiness continues to elude most people. Our inner lives have, if anything, become marked by greater turmoil and confusion. This lack of inner peace and contentment is reflected in the external strife and unrest that, today, marks life throughout the world. People are losing their love and respect for, and their faith in, fellow beings. The gap between human beings and nature – to which we are inherently connected – is constantly widening. If our increasing knowledge is truly helping us to grow and society to progress, why is all this happening? Shouldn’t open communication and friendship also be growing?

One of the main reasons for this is the segregation of science and spirituality. In truth, these two branches of knowledge complement each other – both are required. Unfortunately, society is trying to segregate human kind into spiritual people and scientific people. Most scientists say spirituality is based on blind faith, whereas science is fact, proven through experimentation. Thus, they ask… ‘Which side are you on? The side of blind faith or the side of proven fact?’

Actually, spirituality is not without its proofs. The great sages also conducted research – only their research was not done in an external laboratory, but in the inner laboratories of their minds. Through intense inner inquiry, they arrived at answers to questions that have haunted human kind for ages… What is the nature of experienced world? What is the nature of the mind? How does it function in perfect harmony? From where did it come? Where is it going? Where will it lead? Who am I?

Scientific knowledge and spiritual knowledge are like two strings. If we merge these two streams, we will find that we are able to create a mighty river, a river whose water can remove suffering and facilitate the holistic growth of society. True knowledge is, in fact, like a river that nourishes culture wherever it flows. However, if knowledge is devoid of values, it becomes a source of destruction for the world. However, when values and knowledge come together, there can be no more powerful an instrument for the welfare of human kind.

We are standing on the threshold of a new era wherein material science and spirituality will move forward hand in hand. Physicists have already begun investigating the possibility that – just as the saints and seers have said for millennia – the essential substratum of the universe and the individual are one and the same. Amma prays to paramatman that our minds become expansive enough to embrace both scientific knowledge and spiritual wisdom.

Mata Amritanandamayi Chancellor, Amrita University

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Book of Abstracts 10

Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Book of Abstracts 12 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Inaugural Session

Venue: Conference Hall, Amrita Institute of Medical Sciences, Kochi, Kerala 06 August, 2017 Time: 12 noon to 1 pm

Prayer

Welcome Address: Br. Sankara Chaitanya, Medical Director, Amrita School of Ayurveda

Benedictory Address: Swami Amritaswarupananda Puri, Vice Chairman, Mata Amritanandamayi Math, Amritapuri

Inaugural Address: Sri. Shripad Naik, Hon’ble Minister of AYUSH, Govt. of India

Launch of Amrita Lepam - Multipurpose Universal Ayurvedic Bandage

Guests of Honour: Dr. Rajesh Kotecha, Spl. Secretary, Ministry of AYUSH Dr. Vanitha Muralikumar, President, CCIM, Govt. of India Dr. PR Krishnakumar, Chancellor, Avinashilingam Universiity Dr. A Jayakumar, Secretary General, Vijnana Bharati

Felicitations: Dr. Prem Nair, Medical Director, Amrita Institute of Medical Sciences Dr. Shanti Nair, Dean of Research, Amrita University Dr. Bipin Nair, Dean, Amritapuri Campus, Amrita University

Vote of Thanks: Dr. Ram Manohar, Research Director, Amrita School of Ayurveda

Book of Abstracts 13 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Valedictory Session

Venue: Conference Hall, Amrita Institute of Medical Sciences, Kochi, Kerala Time: 4 pm to 5 pm

Prayer

Welcome Address: Dr. M. Vijayakumar, Clinical Professor, AIMS, Kochi

Benedictory Address: Swami Poornamritananda Puri, General Secretary, Mata Amritanandamayi Math, Amritapuri

Impressions of the Conference: Dr. Rajesh Kotecha, Spl. Secretary, Ministry of AYUSH Dr. Jeffrey White, Director, National Cancer Institute, USA

Guests of Honour: Dr. Ketaki Bapat, Scientific Advisor to Government of India Dr. Abhimanyu Kumar, Director, All India Institue of Ayurveda

Conference Summary

Formation of Integrative Medicine Society, Society for Integrative Oncology

Introducing Journal of Integrative Health

Vote of Thanks: Dr. M.R. Vasudevan Nampoothiri, Principal, Amrita School of Ayurveda

National Anthem

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Schedule Plenary Sessions on August 6, 2017 @ Main Conference Hall

Time Plenary Session One - Integrative Medicine: Definitions, Protocols and Speakers Regulatory Hurdles

8:40 Prayer

8:45 Opening Remarks Dr. Shantikumar V Nair

8:50 Evidence Based Integration of Ayurveda and Modern Medicine Dr. M. Vijaya Kumar

9:05 Integrative Medicine: Ground Realities, Challenges and Journey into the Future Dr. P. Ram Manohar

9:20 Remarks of Chairpersons Dr. Darshan Shankar, Smt. Shailaja Chandra

Time Plenary Session Two - Integrative Clinical Practice: Musculoskeletal Diseases Speakers

9:45 Methodology for testing Ayurvedic Therapy in Rheumatoid Arthritis: Are we ready? Dr. Daniel E Furst

10:05 Comparative Effectiveness of Ayurveda and Conventional Care in Knee Osteoarthritis - a Dr. Christian Kessler Randomized Controlled Trial

10:20 Remarks of Chairpersons Dr. Vishal Marwah, Dr. Sanjeev Rastogi

Time Featured Plenary Lecture on Chronic Renal Failure Speakers

10:30 Ayurvedic management of Chronic Renal Failure: A promising and supportive alternative Dr. Shivnarine Gupta

Time Plenary Session Three - Integrative Clinical Practice: Cancer Speakers

10:45 Cancer: Complementary and Integrative Approaches Dr. Jeffrey White

11:05 Integrative Oncology: A Discipline of Modern Science with the wisdom of Tradition Dr. Ravi Mehrotra

11.20 Integrative Oncology: Opportunities, Challenges Dr. K. Pavithran

11.35 Remarks of Chairpersons Dr. Abhimanyu Kumar, Dr. SP Sardeshmukh

Time Plenary Session Four - New Paradigms in Mental Health from Yoga and Ayurveda Speakers

14:00 Neurobiology of Yoga Dr. BN Gangadhar

14:15 Promoting mental health in chronic disease: the advantages of an integrated perspective Dr. Antonella Delle Fave

14:30 Opportunities, Challenges and Road Map for Integrative Approach to Mental Health Dr. N. Dinesh (Chair)

Time Plenary Session Five - Clinical Experiences in Integrated Cancer Care Speakers

14:45 Need for Integration in Oncology Dr. Arvind Kulkarni

15:00 Integrative Approach of Cancer Treatment Dr. Vineeta Deshmukh

15:15 Clinical Experiences in Cancer to Evolve Drug Research Approaches Dr. Narendra Bhatt (Chair)

Time Plenary Session Six - Clinical Experiences in Neurodegenerative Diseases Speakers

15:45 Ayurvedic Pathological States of Parkinson’s Disease Dr. Gopakumar

16:00 Neurodegenerative Diseases: Early Intervention and Management Strategies Dr. L Mahadevan

16:15 Clinical Experiences in Integrative Practice Dr. Geethakrishnan (Chair)

Book of Abstracts 15 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Parallel Sessions on August 6, 2017 @ Lecture Hall One

Time Parallel Session One: Oncology Speakers

14:00 Role of Ayurveda in Cancer: Cure or Care? Dr. JLN Sastry (Chair)

14:15 Current Integrative Oncology Practices in Kerala Dr. Vijith Sasidhar (Co-Chair)

14:30 OA44 Manohar Gundeti, Amrish Dedge, Govind Reddy and Srikanth N. Integrative Dr. Manohar Gundeti (Ayurveda) Oncology: Where we are and Way ahead

14:40 OA02Rajesh K Singh, Vinamra Sharma, Anil K Singh and Santosh K Singh. Cytotoxicity and Dr. Rajesh K Singh Apoptosis induction of Bioactive fraction of Amoora rohituka Bark in Human Colon Cancer, HCT-15 Cell line

14:50 OA5 Vinamra Sharma, Sahabjada Siddiqui, Rajesh Kumar Singh, Md. Arshad and Anand Dr. Vinamra Sharma Kumar Chaudhary. Kajjali as a potent Anti-leukemic and Apoptosis inducing Ayurvedic Drug in Chronic Myeloid Leukemic Cells; K562 Cell Line

15:00 OA38 Paras Golecha, Siddhisha Kurve and Sheela Pargunde. Assessment of Trailokyasundar Dr. Paras Golecha rasa- a herbo mineral formulation for its efficacy against chronic myeloid leukemia in an in vivo model.

15:10 OA45 Serene Xavier, Sundaram K.R., Dilip Panikar, Shantikumar Nair, Krishnakumar Menon Serene Xavier and Lakshmi Sumitra Vijayachandran. Molecular analysis of Epidermal growth factor receptor (EGFR) gene expression in different grades of gliomas: Critical oncogene for therapy using medicinal plants

15:20 OA49 Sameer Gore, Dhananjay Deshpande, Sushama Bhuvad, Pradnya Tilekar, Sanjog Dr. Sameer Gore Awalkanthe, Bhuvnesh Sharma, Sadanand Sardeshmukh and Vineeta Deshmukh. Effectiveness of adjunct Ayurvedic treatment in cancer control, and improving well-being in rare and advanced cancers

Time Parallel Session Four: Oncology, Hematology Speakers

15:45 Palliative Medicine and Ayurveda Dr. Sanjay Pisharodi (Chair)

16:00 Ayurvedic Intervention in oncology in purview of Epigenetics Dr. Pooja Sabharwal (Co-Chair)

16:15 OA54 Rabinarayan Tripathy and Susmita Priyadarshinee Otta. Understanding Cancer In Dr. Rabinarayan Tripathy Ayurveda And Its Integrative Management

16:25 OA50 Shweta Gujar, Sadanand Sardeshmukh, Vineeta Deshmukh, Arvind Kulkarni, Sudha Dr. Shweta Gujar Gangal, Renuka Gayal, Swapna Kulkarni and Sushrut Sardeshmukh. Assessment of role of Panchakarma and allied procedures in management of side-effects of Radiotherapy in oral cavity cancer patients

16:35 OA51 Abhishekh Salunkhe, Renuka Gayal, Sadanand Sardeshmukh, Vineeta Deshmukh, Dr. Abhishekh Salunkhe Shweta Gujar, Arvind Kulkarni and .Dhananjay Deshpande. Effect of Krumighna and Erandamuladi Basti Chikitsa on Quality of life in Cancer Patients

16:45 OA52 Vasanti Godse, Shweta Gujar, Sadanand Sardeshmukh, Vineeta Deshmukh, Arvind Dr. Vasanti Godse Kulkarni, Tushar Patil, Sudha Gangal, Swapna Kulkarni and Anjali Deshpande. Effectiveness of Ayurvedic medicines in reducing adverse effects of chemotherapy and improving quality of life of breast cancer patients

16:55 OA 53 Shrinivas Datar, Swapna Kulkarni, Nilambari Patil, Amruta Salunkhe, Suchita Vaidya, Dr. Shrinivas Datar Anita Shingte, Vijay Radye, Sadanand Sardeshmukh and Vineeta Deshmukh. Role of adjunct Ayurvedic treatment in increasing disease free survival and improving quality of life in cancer patients.

17:05 OA32 Beena Rose P.K, Anita Patel and Asha K.V. Role of Ayurvedic management in Dr. Beena Rose P.K Glanzmann Thromboasthenia -A case report

Book of Abstracts 16 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Parallel Sessions on August 6, 2017 @ Lecture Hall Two

Time Parallel Session Two: Paediatrics, Diabetes, Nephrology Speakers

14:00 Antibacterial effect Ayurvedic herbal formulation on Methicillin-resistant Staphylococcus Dr. Sintija Sausa (Chair) aureus (MRSA) in diabetic foot patients

14:15 Integrative Approach to Complementary Baby Feeding Dr. Adriana Elaskar (Co-Chair)

14:30 OA31 Gayathri S Nair, Roshni Anirudhan, Mini Muralidhar, Sohini S and Lekshmi Mk. Dr. Gayathri S Nair Management of Autism with Ayurveda-A CaseSeries

14:40 OA12 Trupti Motghare and Rakesh Kumar Nagar. Clinical Evaluation of Effect of Rajanyadi Dr. Trupti Motghare Churna on Morbidity Incidence in Primary Dentitional Age Group i.e. 6-24 Month, Against Micronutrient Therapy

14:50 OA42 Dr. Manoj Ranjan Meher, Dr. Gopikrishna B. J. and Dr. Avnish Pathak. Integrated Dr. Manoj Ranjan Meher Approach For The Management Of Fournier’s Gangrene (Kotha) - A Case Study

15:00 OA14 Anupama J Dileep, Sundara Raman, K.Siva Balaji and Ashwini Belludi. A pre-test and Dr. Anupama J Dileep post-test study to assess the effect of virechana in lowering lipid profile

15:10 OA08 Mansi Manish Patel, Manish V Patel, Kalapi B Patel and S N Gupta. An uncontrolled Dr. Mansi Manish Patel open labeled pre and post designed interventional clinical study to evaluate the effect of Ayurvedic treatment on deceleration of disease progress in non-dialysis stage iv-v patients of chronic renal failure

15:20 OA21 Preethi Mohan, Abhaya Kumar Mishra. Effectiveness Of Ayurvedic Treatment In Acute Dr. Preethi Mohan Renal Failure In Bites Of Vipera russeli - Study Protocol For A Randomised Controlled Trial

Time Parallel Session Five: Diabetes, Endocrinology, Urology Speakers

15:45 Dietetics in Diabetes Mellitus Dr. Vasudevan Nampoothiri (Chair)

16:00 Integrative Ayurvedic Care in Diabetes Mellitus – Clinical Experiences Dr. Prakash (Co-Chair)

16:15 OA10 Lovelesh Gupta, Srinidhi Kumar K, Role of an Indigenous Compound with caloric diet Dr. Lovelesh Gupta and fixed daily regimen in Sthaulya in Childhood Obesity

16:25 OA33 Lakshmy C Senan, Balaji Subrahmonyan, Shaithya Raj, Rabinarayan Tripathy. Dr. Lakshmy C Senan Ayurvedic assessment in management of Graves Disease - A Case Study

16:35 OA34 Manish Patel, Daniel Scheidbach, Bhumika Patel, Mansi Patel, Kalapi Patel and S N Dr. Manish Patel Gupta. Evaluation of Ayurvedic treatment along with conventional modern anti- hyperglycemic drug in the management of diabetic sensory peripheral polyneuropathy - An investigator blinded randomized controlled trial

16:45 OA47 Raghavendra Shettar, Shikha Sikri. Effect of Dashamoola ksheeravasti over Dr. Raghavendra Shettar Gabapentin in the management of Diabetic Peripheral Neuropathy

16:55 OA30 H B Bismi, P V Anandaraman, C K Prathibha. UttaraBasti (Intravesical drug delivery) – Dr. H B Bismi An Effective Therapy for Chronic Urinary Tract Infection

17:05 OA 48 Biju Balakrishnan, Nicky Haridas, Pallavi Menon, Jayachandran Perayil, Lakshmi Dr. Biju Balakrishnan Puzhankara, Rajesh Vyloppillil, Angel Fenol, Mohammed Shereef, Anuradha Bhaskar, Maya George, Reshma Suresh, Musa Paradisiaca-The Anticalculus Agent: To Explore the Unexplored

Book of Abstracts 17 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Parallel Sessions on August 6, 2017 @ Lecture Hall Three

Time Parallel Session Three: Neurology Speakers

14:00 Implementation of integrating allopathy and ayurvedic therapy for neurological disorders Dr. Shyam Unnikrishnan (Chair)

14:15 Connecting Data to Clinical Predictions: Using Computational Neuroscience for bridging Dr. Shyam Diwakar (Co-Chair) Modern Medicine to Ayurvedic explorations

14:30 OA15 Wasuki Upadhyaya, Prophylactic actions of Medhya rasayana drug- Shankhapushpi Dr. Wasuki Upadhyaya (Convolvulus pleuricaulis Chois) on Drosophila (common fruit fly) model of Alzheimer's diseases

14:40 OA07 Kalapi Patel, Namrata Shah, Mansi Patel, Manish Patel, S N Gupta. Management of Dr. Kalapi Patel Parkinson’s disease with multi-phasic multi-modal Ayurvedic treatment – an observational clinical study

14:50 OA18 Indulekha V C, Radhakrishnan V N, Chandra S R. A Controlled clinical study to evaluate Dr. Indulekha V C the efficacy of Ayurvedic treatment in patients with cerebrovascular accident of more than two years duration.

15:00 OA24 Binth Salim Rakhi, C K Prathibha, K Namboothiri Parameswaran. Ayurvedic Dr. Binth Salim Rakhi Management Which Reduced Dose Of L-Dopa And Progression Of Symptoms In Parkinson’s Disease - A Case Report

15:10 OA46 Ravi Sankaran, Ravindranath Kamath, Anandkumar A. A prospective study on the Dr. Ravi Sankaran effects of Ayurvedic massage in post-stroke patients.

15:20 OA41 Sruthi Nambiar, James Chacko. Sensitivity of Heart Rate Variability frequency bands in Dr. Sruthi Nambiar a day– A pilot Study

Time Parallel Session Six: Trauma, Musculoskeletal Diseases Speakers

15:45 Integrated approach in Trauma Care Dr. C Suresh Kumar (Chair)

16:00 Integrative Medicine in Infectious diseases and Immunology Dr. Uma Shankar Prasad (Co-Chair)

16:15 OA01 Elakkiya Venugopal, Sujith Subash Eranezhath, Amitava Bhattacharyya and Selvakumar Dr. Elakkiya Venugopal Rajendran. In vitro evaluation of phytochemicals from Murivenna oil and Wattakaka volubilis leaf on fibroblast cells

16:25 OA11 Parvathy S and Shrikanth P. An Experimental Evaluation Of Chincha Cork And Seed Dr. Parvathy S W.S.R To Wound Healing Property

16:35 OA26 Malu.S. Vimal, James Chacko, Devipriya Soman. Reduction In Score On Oswestry Dr. Malu.S. Vimal Disability Index In Lumbar Spondylosis After An Ayurvedic Intervention - A Case Study.

16:45 OA28 Athira MP, Dr Ananthram Sharma, Prathibha Ck. Reporting The Clinical Outcome Of Dr. Athira MP Bahiparimarjana Chikitsa In Combination With Active Resisted Exercise In Osteoarthritis Knee- A Case Series Study

16:55 OA31 Sandu Pillai, James Chacko, Krishnakumar K. An Ayurvedic management of Adhesive Dr. Sandu Pillai capsulitis -A Case report

17:05 OA40 Dhanya K.V, M.R. Vasudevan Nampoothiri, Sasikumar V.K.. Successful Management of Dr. Dhanya K.V Ankylosing Spondylitis with Ayurvedic Interventions - A case report

Book of Abstracts 18 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Panel Discussion One on August 6, 2017 @ Main Conference Hall 16:30 to 17:15 Integrative Medicine: Policies and Strategies Chairs: Smt. Shailaja Chandra, Dr. Darshan Shankar, Coordinator: Dr. P. Ram Manohar Discussants: Dr. Rajesh Kotecha, Dr., Dr. Shanti Nair, Dr. Abhimanyu Kumar, Dr. Jeffrey White, Dr. JLN Sastry

Break Out Session One on August 6, 2017 @ CNSMM Conference Hall 14:00 to 15:30 Musculoskeletal Diseases Chairs: Dr.Daniel Furst, Dr. Vishal Marwah, Session Coordinator: Girish Tillu

Entry restricted to 50 participants. Please preregister and obtain entry coupons.

Break Out Session Two on August 6, 2017 @ Lecture Hall 4 14:00 to 15:30 Diabetes Chairs: Dr. Valdis Pirags, Dr. Harish Kumar, Session Coordinator: Dr. Pawan Kumar Godatwar

Entry restricted to 50 participants. Please preregister and obtain entry coupons.

Break Out Session Three on August 6, 2017 @ CNSMM Conference Hall 15:45 to 17:15 Integrative Medicine: Networking and Communication Chairs: Dr. Rajesh Kotecha, Dr. Shanti Nair, Session Coordinator: Dr. P. Ram Manohar

Entry restricted to 50 participants. Please preregister and obtain entry coupons.

Break Out Session Four on August 6, 2017 @ Lecture Hall 4 15:45 to 17:15 Neurodegenerative Diseases Chairs: Dr. Nereo Bresolin, Dr. Anand Kumar, Session Coordinator: Dr. Shyam Diwakar

Entry restricted to 50 participants. Please preregister and obtain entry coupons.

Cultural Event on August 6, 2017 @ Main Conference Hall 18:30 onwards Classical Dance Performances

Banquet Dinner 19:30 onwards Entry restriceted to those who have preregistered. Registration to Banquet Dinner is closed.

Book of Abstracts 19 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Plenary Sessions on August 7, 2017 @ Main Conference Hall

Time Plenary Session Seven: Basic Research and Biological Mechanisms: The Science Speakers behind Integrative Medicine

8:40 Prayer

8:45 What should we talk about when we talk about basic research in Ayurveda? Dr. Rama Jayasundar

9:00 Immunomodulatory effects of herbal extracts of Ayurvedic formulary (AF) on immune Dr. Krishnakumar Menon response and its implications in multiple sclerosis

9:15 A Science Initiative in Ayurveda Dr. Ketaki Bapat

9:20 Remarks of Chairpersons Dr. Asoke Banerjee, Dr. Dinesh Katoch

Time Plenary Session Eight: Integrating Technologies for Empowering Integrative Speakers Medicine

9:45 Opportunities for Integrating Ayurveda with Nanotechnology Solutions in Healthcare Dr. Shantikumar V Nair

10:00 Efficacy of Biodegradable Panchvalkala Scaffold in Management of Infected Wound Dr. Manoranjan Sahu

10:15 Amrita Lepam-Universal Ayurvedic Bandage: A Technology Platform for Dermal Delivery and Dr. Jayakumar Therapeutics

10:30 Remarks of Chairpersons Dr. Bipin Nair, Dr. Anand Chaudhary

Time Plenary Session Nine: Integrative Clinical Practice: Neurodegenerative Diseases Speakers

11:00 Integrative Approach to Neurodegenerative Diseases Dr. Nereo Bresolin

11:15 New insights from Ayurveda reading of Neurological Diagnostic Tests Dr. Antonio Morandi

11:30 Integration of Allopathy and Ayurveda for Neurological disorders Dr. Anand Kumar

11.45 Remarks of Chairpersons Dr. Rajesh Kotecha, Dr. Antonella

Time Plenary Session Ten: Integrative Clinical Practice: Diabetes Mellitus Speakers

12:00 Comparison of Clinical Trials in Ayurveda and Modern Medicine: The case of Diabetes Mellitus Dr. Valdis Pirags

12:15 Opportunities and Challenges for Ayurveda in management of Diabetes Dr. Harish Kumar

12:30 Remarks of Chairpersons Dr. MR Vasudevan Nampoothiri, Dr. Ramesh R Varier

Time Featured Plenary Lecture on HIV Infection Speakers

12:45 Holistic Approach to HIV Infection Dr. Gireesh Kumar

Time Plenary Session Eleven: Clinical Practice and Research in Integrative Medicine Speakers

14:00 Integrative Medicine: Protocols for Clinical Research Dr. Anupama Kizhakkeveettil

14:15 Integration of Medical Systems in Neurology Dr. Sandeep Nair

14:30 An Integrated Approach to Treatment of Degenerative Neurological and Musculoskeletal Dr. Ramesh R Varier (Chair) Diseases – Our Clinical Experience

Book of Abstracts 20 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Parallel Sessions on August 7, 2017 @ Lecture Hall One

Time Parallel Session Seven: Basic Science, Pulmonology Speakers

14:00 Sleep Medicine: What Ayurveda Can Contribute? Dr. Sanjeev Rastogi (Chair)

14:15 Triphala: Understanding biological mechanism for management of obesity Dr. Supriya Bhalerao (Co-Chair)

14:30 Drug Discovery from Plant Sources using AyurInformatics Approach Dr. Gopi Mohan (Co-Chair)

14:45 OA13 Rajesh Jain, Jyoti Shankar Tripathi. Impact of EMDR On Cardio Function Dr. Rajesh Jain

14:55 OA06 Haritha Chandran, Mallika Kurat Jayavarma, Moinak Banerjee. DNA methylation Dr. Haritha Chandran analysis correlates environmental influence on extreme vata constituition defined in Ayurveda

15:05 OA03 Sandeep Binorkar, Anand Kulkarni. Appraisal Of Prakriti And Its Relation With Dr. Sandeep Binorkar Dactylography

15:15 OA20 Jyotish S Jayandan, Mahesh C Kundagol, James Chacko. Clinical and Immunological Dr. Jyotish S Jayandan outcomes in a case of Allergic Asthma through Ayurvedic Management- A Case Report

15:25 OA27 Renju Rajan, Delvin.T Robin, Vandanarani M. Nebulization In Ayurveda -A Novel Way Dr. Renju Rajan Of Drug Delivery In Bronchial Asthma

15:35 OA09 Resmi BG, Ajitha K, Abhilash M, Revalidation Of The Concept Of Apara Ojus By The Dr. Resmi BG Assessment Of Haematological Parameters In Children With Recurrent Respiratory Tract Infection

Parallel Sessions on August 7, 2017 @ Lecture Hall Two

Time Parallel Session Eight: Gastroenterology, Dermatology Speakers

14:00 Medoroga: Precursor of Diabetes Dr. Pawan Kumar Godatwar (Chair)

14:15 Ageing, Cellular Senescence, Cancer and the Role of Rasayana Dr. Rajmohan (Co-Chair)

14:30 P’ for Patterns: An Approach for Observational Research Exploring Clinical Data Dr. Girish Tillu (Co-Chair)

14:45 OA16 Jithesh Madhavan, Renuka R Gayal. Mahatiktaka Kwatha Vs Kwatha Tablet in Dr. Jithesh Madhavan Functional Dyspepsia - A Randomized Controlled Trial

14:55 OA22 Sreelekshmi GU, James Chacko, Krishnakumar K. Management of Ascites through Dr. Sreelekshmi GU Ayurveda- A Case study

15:05 OA39 Hardik Patel, S N Gupta. Successful Ayurvedic Management Of Chronic Alcoholic Dr. Hardik Patel Hepatitis Complicated With Ascites: A Case Report

15:15 OA25 Santosh Sathyarthi, Prasanna Rao, Management Of Bhagandra (Fistula-In-Ano) With Dr. Santosh Sathyarthi Integrative Surgery (Allopathy And Ayurveda) - A Case Report

15:25 OA19 Baidyanath Mishra, Vivekanand Ramana. Anti-proliferative Effects of an Herbal Dr. Baidyanath Mishra Formulated Cream on Human Keratinocytes and its Implication for Psoriasis Treatment

15:35 OA23 I V Aiswarya, K Namboothiri Parameswaran, P V Anandaraman, Effect of a Dr. I V Aiswarya Multimodality Ayurvedic Treatment in a Case of Vesiculobullous Disease

Book of Abstracts 21 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Parallel Sessions on August 7, 2017 @ Lecture Hall Three

Time Parallel Session Nine: Pharmacology, Pharmaceuticals, ENT, Ophthalmology Speakers

14:00 Safety of Ayurvedic formulations including drug herb interactions Dr. Anand Chaudhary (Chair)

14:15 Integrative Clinical Practice: A decade’s experience Dr. Kamath CR (Co-Chair)

14:30 Integration in education: Cross-System challenges between Ayurveda and Medical Science Dr. AN Narayanan Nambi (Co-Chair)

14:45 OA17 Lekshmi Priya S, Sarath Chandran C, Aneesh M B , Divya P. Metamorphosis Of A Dr. Lekshmi Priya S Classical Formulation Into A Value Added New Dosage Form

14:55 OA37 Shubha P U, Sudheendra V. Honwad, Shrinidhi R. Evaluation Of Protective Role Of Dr. Shubha P U Bilwadi Gutika In Lead Induced Toxicopathological Condition In Wistar Albino Rats

15:05 OA35 Neeraj AK, Prasad UN, Swapna Swayamprabha, Evaluation of Hepatoprotective And Dr. Neeraj AK Nephroprotective Potential Of Bilvadi Gutika In Cypermethrin Induced Toxicity In Wistar Albino Rats

15:15 OA36 Renuka Munshi, Samidha Joshi, Dipti Kumbhar. An experimental study to assess the Dr. Renuka Munshi anti-osteoporotic effect of Panchatikta ghrita (PG) in an ovariectomized rat model of Osteoporosis

15:25 OA43 Veeranagouda.S. ,Dhiman K S, Amith J Mehta. Role Of Chakshusya Rasayana Dr. Veeranagouda.S (Neuroprotection)In The Management Of Progressive Glaucomatous Optic Neuropathy- A Clinical Study

15:35 OA04 K.Siva Balaji, Ashwini BN. Shrinkage And Non-Recurrence Of Ehmoidal Nasal Polyp Dr. K.Siva Balaji With Ayurvedic Management - Case Report

Panel Discussion Two on August 7, 2017 @ Main Conference Hall 14:45 to 15:30 Integrative Medicine: Clinical Integration Chairs: Daniel Furst, Dr. Dinesh Katoch Discussants: Dr. Pavithran, Dr. Ravi Mehrotra, Dr. Sanjeev Rastogi, Dr. Geethakrishnan, Dr. Manoranjan Sahu

Break Out Session Five on August 7, 2017 @ CNSMM Conference Hall 14:00 to 15:30 Cancer Chairs: Dr.Jeffrey White, Dr. SP Sardeshmukh, Session Coordinator: Dr. Vijith Sasidharan

Entry restricted to 50 participants. Please preregister and obtain entry coupons.

Break Out Session Six on August 7, 2017 @ Lecture Hall 4 14:00 to 15:30 Mental Health Chairs: Dr. Antonella Delle Fave, Dr. N. Dinesh, Session Coordinator: Dr. Rama Jayasundar

Entry restricted to 50 participants. Please preregister and obtain entry coupons.

Book of Abstracts 22 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Poster Session One on August 6, 2017 @ Poster Hall, 14:00 to 15:30

Biomedical Engineering Presenter

PA38 PB Kadambari, C K Prathibha, P V Anandaraman. Development Of A Portable, Cost Effective, And Efficient Shirodhara Dr. PB Kadambari Instrument With Diverse Technologies

Cardiology Presenter

PA24 Haris Cholakkal. An Experimental Study To Evaluate The Cardioprotective Activity Of Ajeya GhrITha In Albino Rats Dr. Haris Cholakkal

Dentistry Presenter

PA66 Biju Balakrishnan, Roshni Nair, Jayachandran Perayil, Angel Fenol, Lakshmi Menon, Rajesh Vyloppillil, Anuradha Dr. Biju Balakrishnan Bhaskar, Mohammed Shereef, Maya George and Dr.Reshma Suresh. Triphala ayurvedic mouth rinse- rediscovering the past

PA67 Lakshmi Puzhankara. Onion (Allium cepa) and pomegranate (Punica granatum) as local drug delivery agents in Dr. Lakshmi Puzhankara periodontal disease.

Dermatology Presenter

PA29 Aramya A R. Role of Śodhana in the management of Sidhmakuṣṭha: A case report Dr. Aramya

PA50 Sarath S. Successful Management Of Khalithya (Hair Loss) With Ayurvedic Treatment – A Case Study Dr. Sarath S

PA51 Siddhisha Kurve, Paras Golecha, Rupa Kadam. Evaluation of in vitro melanogenesis inhibition activity of Kadamba Dr. Siddisha Kurve (Anthocephalus cadamba Miq.)

PA62 Kalpana Rao, Mythrey R.C, Gajanana Hegde A Single Case Study On Chronic Plaque Psoriasis Interms Of Dr. Kalpana Rao Ekakushtha.

Diagnostics Presenter

PA23 Shyamasundaran K, Mallika K J, Deepthi Viswaroopan. Use of modern diagnostic techniques in Ayurvedic diagnosis- Dr. Shyamasundaran K An analysis through case studies

PA64 Dr Hrishikesh Othaloor Krishnan, Soumya Saraswathi M, Raghavendra Udupa. Changes in kirlianography before Dr. Hrishikesh Othaloor and after an Ayurvedic Intervention:An observational study Krishnan

Endocrinology Presenter

PA27 Amarnath Shukla, B K Chandravansi. Preliminary study of the role of ayurvedic intervention in type 1diabetes Dr. Amarnath Shukla mellitus (T1DM)

PA33 Sangeeta Sharma, Gopesh Mangal. A Success Story Of Management Of Hypothyroidism With Vamana Karma-A Case Dr. Sangeeta Sharma Study

PA54 Pramod S, Anandaram Sharma Successful management of Obesity with Ayurvedic intervention - A Case Report Dr. Pramod S

ENT Presenter

PA17 Smina PB, A Clinical Case Report On Meniere’s Disease Dr. Smina

PA18 Ganga Hadimani. A Case Study Of SNHL (Tinnituis) Managed By Ayurvedic Treatment Dr. Ganga Hadimani

PA28 Jyotirmoy Sarmah, Hareswar Mahanta, Dipti Rekha Sarma. Management of Chronic Stuffy Nose due to Hypertrophy Dr. Jyotirmoy Sarmah of Inferior Turbinates by Ksharakarma, a Procedure of Chemical Cautery in Ayurveda

Gastroenterology Presenter

PA61 Bijendra Shah, Tukaram Sambhaji Dudhamal. Role of Ksharasutra and Partial Fistulectomy in the management of Dr. Bijendra Shah Fistula in Ano– a Pilot Study

PA20 Neelam Gupta, Shiv Ji Gupta. Effect of Palash (Butea monosperma) on Ovary of Mice – An Evidence Based Study Dr. Neelam Gupta

Book of Abstracts 23 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Gynaecology Presenter

PA20 Neelam Gupta, Shiv Ji Gupta. Effect of Palash (Butea monosperma) on Ovary of Mice – An Evidence Based Study Dr. Neelam Gupta

PA30 Deepika Singh, Asokan Vasudevan. Case Report on the Ayurvedic Management of Endometriotic Cyst of Ovary Dr. Deepika Singh

PA47 Vandana K.Vasudevan, Hemavathi. S.K. Post partum Depression: prevention by diet and psychotherapy Dr. Vandana Vasudevan

PA60 Vidya Pillai. A Case Study On Effective Management Of Preeclampsia With Contempory Medicines Associated With Dr. Vidya Pillai Ayurveda

PA75 Sithara Satheesan, Hemavathi S Improving Low Anti Mullerian Hormone Values For Enhancing Ivf Success Rates : A Dr. Sithara Satheesan Study Proposal

PA01 Kashinath Hadimur. Effect of Shilajatu Rasayana in letrozole-induced polycystic ovarian syndrome Dr. Kasinath Hadimur

Integrative Medicine Policy Presenter

PA08 Akhilesh Shukla, Parameshwaran Ramakrishnan. Perspectives of Traditional and Allopathic Physicians on Spirituality Dr. Akhilesh Shukla and its role in Medicine: Historical Trends and Opportunity of Convergence towards an Integrative Medicine

PA74 Santhosh Thannikkat. Setting a Policy Framework for Integrated System of Medicines Santhosh Thannikkat

Medical Genetics Presenter

PA09 Senthiarasi Thamizhmani. Management of Aicardi syndrome in Ayurveda – case report Dr. Senthiarasi

Musculoskeletal Diseases Presenter

PA21 Dr. Dipti Rekha Sarma and Dr. Jyotirmoy Sarmah. A Clinical Evaluation of Anti Osteoporotic activity of Asthi Dr. Dipti Rekha Samharaka(Cissus quadrangularis) in Post menopausal women

PA40 Aswathi Rajan V.K, Devipriya Soman, Mahesh C Kundagol and James Chacko. Reduction In Score Of DAS 28 In Dr. Aswathi Rajan VK Rheumatoid Arthritis (RA) After An Ayurvedic Management – A Case Report

PA42 Anjana S, Krishna Kumar K, James Chacko and Devipriya Soman. Reduction In Score On Womac Scale In Knee Osteo Dr. Anjana S Arthritis After An Ayurvedic Treatment Protocol - A Case Report

PA43 Deepa J G, P V Anandaraman and C K Prathibha. Pre And Post Clinical Trial To Assess The Efficacy Of Tila Rasayana In Dr. Deepa JG Osteoporosis– A Proposal

PA53 Fasnath Arabi and Jithesh Madhavan. An Algoritham For The Ayurvedic Management Of Ankylosing Spondilitis – A Dr. Fasnath Arabi Case Study

PA55 Rajalekshmi S. Crest Syndrome- A Case Report Dr. Rajalekshmi

PA71 Arya Somasundaran and Dr.Sasikumar V.K. Reduction In Score On Oswestry Disability Index In Intra Vertibral Disc Dr. Arya Somasundaran Prolapse After An Ayurvedic Intervention - A Case Study.

Nephrology Presenter

PA63 Meera S and Vidyaprabha G Pillai. Effect Of Ruksha Vasti On Reducing Renal Parameters In Chronic Dr. Meera S Glomerulonephritis: A Case Report

PA76 Susmitha C, Prakash Mangalasseri. Nephrotic syndrome : Emerging trends in the managing perspective of Dr. Susmitha Ayurveda

Urology Presenter

PA11 Rajeev Kumar Singh, Shiv Ji Gupta and Pradeep Kumar. Treatment option for age related voiding dysfunction in ENT Ayurveda and Contemporary Sciences with special reference to Benign Prostatic Hyperplasia

PA57 A Divya and Jai G. Efficacy of classical combination of “Swarnamakshikabhasma” and its pharmaceutically modified ENT formulation against Veerataraadigana kashaya in treatment of Mutrasmari- A Comparative Clinical Study

Book of Abstracts 24 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Poster Session Two on August 6, 2017 @ Poster Hall, 15:45 to 17:15

Neurology Presenter

PA16 Nimmy V S, Jayasree P , M S Deepa. Anti-convulsant effect of Ksheerabala Taila in albino rats Dr. Nimmy VS

PA36 D H Ajisha, C K Prathibha, P V Anandaraman. An Ayurveda Approach To The Management Of Trigeminal Neuralgia - A Dr. Ajisha Case Report

PA41 Susmi P.S , Pratibha C.K. Pre And Post Test Study To Evaluate The Effect Of Jatiphala Ksheerapaka In The Management Dr. Susumi PS Of Insomnia

PA56 Sujithra R.M, Priya S, Vimala KS, Priyalatha B, Raiby Paul Definition, Classification, Descriptions and Management of Dr. Sujithra RM Pain in Classical Ayurvedic Literature: A Comprehensive Review

Oncology Presenter

PA32 Shruthi Roy and Madhu K.P. In-silico analysis of the drug Sahadevῑ (Cyanthillium cinereum (L.) H.Rob.) in breast Dr. Shruthi Roy cancer

PA35 Yogesh Tamhankar. Screening of Anticancer activity and Immunomodulatory effect of Shataputi Abhrak Bhasma Dr. Yogesh Tamhankar

PA52 S Meera, Delvin T Robin and Vandana Rani M. Systematic Review On Administration Of Brahma Rasayana As An Dr. Meera S Adjuvant To Chemo And Radiation Therapy

PA59 Archana SR, Pratibha CK Reduction In Size Of Thyroglossal Cyst After Application Of Leech- A Case Study. Dr. Archana SR

PA68 Vineeta Awalkanthe, Sadanand Sardeshmukh, Vineeta Deshmukh, Vasanti Godse, Arvind Kulkarni and Sudha Dr. Vineetha Awalkanthe Gangal. Dietary risk factors of colorectal cancer from Ayurvedic perspective

PA69 Sandeep Chavan, Sadanand Sardeshmukh, Vineeta Deshmukh and Sukumar Sardeshmukh. Standardization of Dr. Sandeep Chawan Kamdudha Rasa to understand the mechanism of action as adjunct treatment in management of Chemotherapy and Radiotherapy side effects

PA70 Bhagyashree Sardeshmukh, Shweta Gujar, Sadanand Sardeshmukh, Vineeta Deshmukh, Shreenivas Datar, Swapna Dr. Bhagyashree Kulkarni Kulkarni and Pradnya Kodre. Comparative study of YG2 and YG3 in Yakrut Vikara (HCC, Liver cirrhosis) Sardeshmukh

Ophthalmology Presenter

PA02 Pratibha Upadhyay and Dr.Shamsa Fiaz. Treatment of glaucomatous optic atrophy through ayurveda : a case study . Dr. Prathibha Upadhyaya

PA05 Surangi KG, Shamsa Fiaz. A Clinical Study On The Effect Of Ayurvedic Management Of Kācha With Special Reference Dr.Surangi KG To Immature Senile Cataract

PA07 Nikita Baghel and Prabhakar Vardhan. A Single Case Study On Viral Retrobulber Optic Neuritis Dr. Nikita Baghel

PA15 Poonam Jakhar and Shamsa Fiaz. Ayurvedic approach for management of Age related macular degeneration (non- Dr. Poonam Jakhar exudative type) — A case report

Paediatrics Presenter

PA13 M K Lekshmi. Ayurvedic Intervention With Rehabilitative Therapies Improve Development In Children With Cerebral Dr. MK Lekshmi Palsy

PA14 Sonam, Arun Kumar Mahapatra and Rajagopala. S. Pañcakarma therapy in Cerebral Palsy (CP) in a tertiary care Dr. Sonam - A case study

PA25 Rahul Ghuse, Virendra Kori, Rajgopala Shrikrishnan, Kalpana Patel. Clinical Study on Cerebral Palsy and its Dr. Rahul Ghuse Management with Shastika Shali Pinda Sweda and Yoga Basti.

Pharmaceuticals Presenter

PA04 Geethu Balakrishnan, Arun Mohanan, Ramesh N.V. Distillation As A More Potent Alternative To Decoction Of Jati Dr. Geethu Balakrishnan (Jasminum Grandiflorum) As A Mouthwash.

PA19 Vandana Singh, Ramesh Kumar. Study of Phytochemical constituents and antioxidant activity of Beta vulgaris Dr. Vandana Singh

Book of Abstracts 25 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA22 Shakti Bhushan, Kapil Deo Yadav and Anand Chaudhary. Anti-aflatoxin and Anti-oxidant Activity of Sahaj vati: A Dr. Shakti Bhushan Novel Herbomineral Formulation as Shelf life Enhancer

PA26 Anjana C.S, Jacob.M Titus, Dr.Harisankar D, Rajeev V.R. Study and Optimization Of the Process Parameters of Sulphur Dr. Anjana CS Purification

PA31 Prajkta Kulkarni. Physicochemical analysis of jalateertha Dr. Prajkta Kulkarni

PA49 Vineeth P K, Abhaya Kumar Mishra. Modification of milk decoction(Ksheerapaka)of Tribulus terrestris into Dr. Vineeth PK dehydrated milk powder – A proposed technology integration.

Pharmacology Presenter

PA03 Shruti Pandey, Anand Chaudhary. In Vitro Drug Release And Study Of Anti-Inflammatory Effect Of Rasna Saptak Dr. Shruthi Pandey Kwath As Topical Drug

PA06 Shikha Lekharu, Khagen Basumatory, An invitro study of yograj churna on antioxidant activity Dr. Shikha Lekharu

PA37 Reshma Ramakrishnan, C K Prathibha, P V Anandaraman. In-Silico And In- Vitro Study To Understand The Molecular Dr. Reshma Ramakrishnan Mechanism Of Emetic Action Of Identified Phytochemical Compounds In Madanaphala Medicinal Plant (Randia Dumetorum) Mediated By 5Ht3 And Nk1 Receptors’’– A Proposal

PA73 Swati Gupta, Deepa Subramanian. Pharmacokinetic Study Of Amaranth Extract In Healthy Humans: A Randomized Dr. Swati Gupta Trial

Physiology Presenter

PA48 Eeshan Phatak, Sumant Gaopande, Abhishek Patil, Yudhishthir Deshpande, Jayshree Ghorpade-Aher, Kalyani Dr. Eeshan Pathak Deopujari and Aniruddha Joshi. Studying the effects of Suryanamaskar using signal processing techniques

Podiatry Presenter

PA58 Shalini U. A., Siddayya Aradhyamath, Pravini Valsalan. Management of diabetic foot ulcers by the integrated Dr. Shalini UA treatment of Ayurveda and a course of antibiotics – A case report

PA12 Lakshmi V, Dilip Kumar K V. An Interventional Trial On Promotion Of Positive Health Through Seasonal Purification In Dr. Lakshmi V Relation With Pitta

Psychiatry and Psychology Presenter

PA39 Chandni C Pillai, Mahesh C Kundagol, James Chacko and Devipriya Soman. An Ayurvedic Management Protocol In Dr. Chandni C Pillai Generalized Anxiety Disorder- A Case Study

PA46 Shivateja Jagarlamudi, Sushma Cittodvega: Emergence of disease nomenclature from a possible scribal error Dr. Shivteja Jagarlamundi

PA72 Mauli Vaishnav. Clinical Evaluation Of Effect Of Music With Creative Visualization On Maternal Psychology Dr.Mauli Vaishnav

Pulmonolgy Presenter

PA10 Devendra Kumar, Nisha Ojha. Clinical Study to Evaluate the Efficacy of Drakshadi Yog in the Management of Dr. Devendra Kumar Respiratory Allergic Disorders of Children

PA44 Rakhi Rajeev R, P V Anandaraman, K Parameswaran Namboothiri. An Invitro Study To Evaluate The Antibacterial Dr. Rakhi Rajeev Property Of Haridradi Varti Dhuma (Medicated Smoke) Against Respiratory Pathogens

Toxicology Presenter

PA34 Baidyanath Mishra, Sujan Ganapathy, Sujata Mishra Antioxidative mode of action of Bacopa monnieri Dr. Baidyanath Mishra (predominantly bacosides) in preventing the neuronal cell from oxidative damage

PA65P Rinsitha, S Sunil Kumar and M Gauthaman. Suddha-asuddha bhallataka taila(Oil extract from Semecarpus Dr. Rinsitha S anacardium)- A Sub-acute toxicity evaluation.

Book of Abstracts 26 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Distinguished Guests

Swami Amritaswarupananda Puri is Vice Chairman of Mata Amritanandamayi Math and the President of the Amrita Vishwa Vidyapeetham University. He is is a senior disciple of and also the first disciple who had been initiated into Sanyasa by Mata Amritanandamayi Devi. Swamiji has been at the forefront of all the socio-humanitarian initiatives undertaken by the Mata Amritanandamayi Math in the country and abroad. Swamiji’s impeccable oratory is well-matched by his soulful rendering of bhajans.

Swami Poornamritananda Puri is the General Secretary of Mata Amritanandamayi Math. is a senior sannyasi disciple of Amma. An engineer and research scientist by training, Swamiji found Amma many years ago in search of his quest for God. In his years staying close to Amma, living and transforming himself, Swamiji has embodied Amma’s message of love and peace. His sweet temperament and simplicity have endeared him to many all over the world, both children and adults alike, traveling alongside Amma and on his own to share the wisdom of Amma’s vision.

Shripad Yesso Naik is the Member of Parliament from North Goa constituency representing the Bharatiya Janata Party. He is member of Union Minister of State (Independent Charge) Ministry of Ayurveda, Yoga & , Unani, Siddha and Homoeopathy (AYUSH); Union Minister of State, Ministry of Health and Family Welfare. He received the Samaraj Ratna Award on 18 August 2016

Dr. Ketaki Bapat, Scientist F, Scientist 'F', Office of the Principal Scientific Adviser to the Govt. of India.Dr. Ketaki Bapat is currently working as a Senior Scientist in the office of Principal Scientific Adviser to Government of India and was working as a Scientific Officer in Radiopharmaceuticals Division, Bhabha Atomic Research Centre, . She is co-ordinating various initiatives such as “Science in Ayurveda”, Rural Technology Action Group, Identifying gifted children in science and maths etc. supported by the office.

Dr.Rajesh Kotecha is an Ayurveda physician who received a Padmashri Award for Medicine in 2015.He is appointed as Special Secretary in the Ministry of AYUSH, Government of India. He is the former Vice Chancellor of Gujarat Ayurveda University, Jamnagar. He founded Chakrapani Ayurveda Clinic & Research Center in Jaipur, India in 1998. He has traveled to many countries for the propagation and practice of Ayurveda. He received the Global Ayurveda Physician Award in 2007, Ayurveda Ratna Award in 2008.

Dr. P.R. Krishnakumar, Chancellor, Avinashilingam Women’s Universtity, and Managing Director, Arya Vaidya Pharmacy, Coimbatore. Padmashree Doctor PR Krishna Kumar (born 23 september 1951) is the son of Arya Vaidyan P. V. Rama Varier, the founder of Arya Vaidya Pharmacy. After studying Ayurveda at the college in Shornur, Kerala he took up preservation and promotion of Ayurveda as his life's mission. As the head of The Arya Vaidya Pharmacy, a premier ayurvedic institution in the country,

Book of Abstracts 27 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Dr. S. P. Sardeshmukh, PhD, Director of Integrated Cancer Treatment and Research Centre, Pune. He has teaching experience of 41 years for Undergraduate (B.A.M.S.), Postgraduate (M.D.) & Post- Doctoral Research (Ph.D.) in Ayurved. Currently, Dean of Ayurved Faculty of Tilak Maharashtra Vidyapeeth, Pune. Invited to deliver lectures & demonstrations for propagation of Ayurved for last 26 years in various countries like Australia, Japan, Germany Switzerland, Vienna, Slovenia, Holland, Italy and USA. More than 7500 cancer patients of various types & stages are treated with Ayurvedic treatment at various centers viz. Pune, Mumbai, Solapur, Kolhapur, Nasik, New Delhi-Gurgaon.

Mrs. Shailaja Chandra IAS, Former Chief Secretary Delhi Government and Secretary AYUSH Government of India.Shailaja Chandra has been a career civil servant for over 40 years. Aside from 15 years with the Central Government where she held assignments in the Ministries of Defence, Power and Health, Ms. Chandra has worked in different parts of the country with the State Governments. She was Health Secretary in Delhi and joined the Government of India as Joint Secretary in the Ministry of Health &Family Welfare where she was promoted as Additional Secretary and later Secretary in the same Ministry

Dr. Darshan Shankar, Advisor, Transdisciplinary University, Bengaluru. Darshan Shankar is the managing trustee of FRLHT and founder of TDU. His core contributions lie in the field of educational innovation. He has won several national and international awards viz. Commonwealth Award (1976), Normal Borlaug Award (1998) for contributions to conservation of wild populations of medicinal plants, Columbia University’s International Award (2003) for Complementary and , and in 2011, the Govt. of India conferred on him, the Padma Shri.

Dr. Dinesh Katoch, Advisor, Ministry of AYUSH where he is assigned with the responsibility of AYUSH Drug Control matters, coordinating formulation of 12th Five Year Plan for AYUSH and dealing with International Cooperation issues in the area of . Dr. Katoch has about 29 years’ illustrious professional experience in clinical, academic, policy, planning and technical advisory fronts related to Ayurveda in particular and traditional medicine in general.

Dr. Vanitha Muralikumar, President, Central Council for Indian Medicine, Government of India. She is also Principal cum Director - Clinical Research Sri Sairam Ayurveda Medical College and Research Centre, . She is also Senate Member - The T.N Dr.M.G.R Medical University, Chennai and Faculty Member - The T.N Dr.M.G.R Medical University, Chennai.

Dr. Abhimanyu Kumar, Director, All India Institute of Ayruveda. He briefly held the charge of Director General, CCRAS, New Delhi. After MD in Ayurvedic Pediatrics, was also awarded with PhD and later received his master's degree (MSc) in applied Psychology and Diploma in Yoga. Authored three books and published 102 research papers in various scientific national and international journals. Supervised 65 MDs and 10 PhD scholars. He has traveled to many countries for the global propagation of Ayurveda.

Book of Abstracts 28 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Dr. Sankara Chaitanya, MD (Ay), Medical Director, Amrita School of Ayurveda, Amrita University, Kollam, Kerala. Br. Sankara Chaitanya is serving as a Professor in the Department of Kayachikitsa. He completed his BAMS from Ayurveda College, Coimbatore under the Gurukula system of training , which was affiliated with University of Madras in 1986. He underwent postgraduate training in Kayacikitsa and obtained MD from Government Ayurveda College, Trivandrum under Kerala University in 1991. He joined Amrita School of Ayurveda in the year 2004 as Assistant Professor.

Dr. Bipin Nair, Director, Amrita School of Biotechnology, Amrita University, Kollam, Kerala. Bipin Nair received his Ph.D. in Microbiology in 1986 from the Department of Microbiology, M.S. University of Baroda, India and received his post-doctoral training at the University of Tennessee, Memphis, USA, in the Dept. of Pharmacology from 1987-1992. His major contributions during that phase were in the areas of growth factor receptor signaling, GTP binding proteins and second messenger pathways. Dr. Nair then moved to the Biotechnology industry in 1993 and held the position of Senior Scientist- Lead Discovery at MDS Pharma Services in Seattle, Washington, USA

Dr. (Col) Vishal Marwaha currently serves as Principal and Professor and Head, at Department of Rheumatology , School of Medicine, Kochi. . His experience include observership at Nottingham University, UK (City Hospital & Queen’s Medical Centre) and training in Rheumatology at All India Institute of Medical Sciences, Delhi. Awards received by him are Manakkal Silver medal (MD General Medicine) - 1995, Young investigator award (APLAR) Jeju, Korea - 2004 and International Scholarship, Japan College of Rheumatology - 2006

Dr. Asoke Banerji has made very significant contributions in diverse areas of biotechnology and basic bioorganic chemistry. He obtained Ph.D. degree under the supervision of Professor T.R. Seshadri, F.R.S. and Professor V.V.S. Murti from the University of Delhi in 1964. He was awarded a senior research fellowship by the International Atomic Energy Agency to work with Professor D.H.R. Barton and Professor E.B. Chain, both Nobel Laureates, at the Imperial College of Science and Technology, London. Dr. Banerji joined Bhabha Atomic Research Centre, Mumbai in 1967 and was Head of the Bioorganic Division from 1989-98.

Sri. A. Jayakumar, Secretary General of Vijnana Bharati and Trustee, World Ayurveda Foundation. He is a senior RSS Pracharak and has spearheaded and guided the World Ayurveda Congress which is organised once in two years. It is one of the largest event for Ayurveda in the world attracting thousands of participants from all over the world. He has also been actively workingh to promote awarness on the scientific contributions of ancient India.

Dr. Prasanna Rao, Principal, SDM College of Ayurveda, Hassan, Karnataka He has a teaching experience of more than two decades. He is a former Executive Member of the Central Council for Indian Medicine (CCIM). Member of P G. Board of studies (Ayu) of RGUHS Member of Academic Council of RGUHS, . He is an able Administrator and has also served as Clinical Registrar, IMS, BHU, Varanasi : From 1st July, 1987 to 27th August, 1993.

Book of Abstracts 29 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Invited Speakers

Dr. Jeffrey White is a board certified medical oncologist and a cancer researcher. Dr. White graduated from Cornell University with a B.S. in Applied and Engineering Physics in 1979 and received an M.D. from Howard University in 1984. He completed a residency in internal medicine in 1987 and fellowships in oncology and hematology in 1990 at The Washington Hospital Center in Washington, D.C. Dr. White joined the Metabolism Branch of the National Cancer Institute (NCI) in 1990 and is presently Director, OCCAM of the National Cancer Instittue.

Dr. Daniel Furst is a rheumatologist in Los Angeles, California and is affiliated with multiple in the area, including UCLA Medical Center and UCLA Medical Center Santa Monica. He received his medical degree from Johns Hopkins University School of Medicine and has been in practice for more than 20 years. Dr. Furst accepts several types of health insurance, listed below. He is one of 45 doctors at UCLA Medical Center and one of 26 at UCLA Medical Center Santa Monica who specialize in Rheumatology.

Dr. Nereo Bresolin is an Eminent Neurologist and Director of the Complex Operative Unit of Neurology of the Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico of Milan, 2) Director of Homogeneous Area of Neurology of the Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico of Milan, 3) Director of the Centro Dino Ferrari, University of Milan, 4) Holder and Referee of Health Research Projects Finalized the Ministry of Health by the University of Milan and the European Community, Member of the Council of the College of Full Professors of Neurology

Dr. Valdis Pirgas is Professor of Medicine & Vice Dean of the Faculty of Medicine, Pauls Stradins Clinical University Hospital, Director of the Centre of Complementary Medicine, University of Latvia, Rains Bulvaris 19, Riga, LV1586, Latvia. He has expertise in Diabetology and Internal Medicine (General Medicine). He is also the Head of the Department of Integrative Medicine at Latvia University, Riga.

Prof. Antonella Delle Fave has an illustrious body of research work to her credit and is currently the Editor in Chief of the Springer group’s Journal of Happiness Studies. She has been the President of IPPA, ENPP & SIPP. Together with international partners she launched and implemented the project “Eudaimonic and Hedonic Happiness Investigation”, aimed at identifying well-being components across cultures. She is currently conducting research and clinical studies aimed at integrating the bio-psycho-social perspective of Western medicine and the Indian traditional view of health and disease.

Dr. med. Christian Kessler is research coordinator and physician at the Charité university outpatient clinic for complementary and integrative medicine, located at Immanuel Hospital Berlin, Germany. He integrates Ayurveda actively in his medical consultations. Moreover, it is one of his goals to scientifically and socially advance Traditional Indian Medicine in Germany and Europe, in particular in the medical arena. Besides this, another practical and scientific interest ís vegetarian nutrition.

Book of Abstracts 30 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Dr. Antonio Morandi is Medical Doctor, Specialist in Neurology and graduated in Ayurveda (Ayurveda Academy, Pune, India and Joytinat International College of Ayurveda), since 2001 is Founder and Director of “Ayurvedic Point”, Milan, Italy and President of the Italian Scientific Society for Ayurvedic Medicine (S.S.I.M.A.). Awarded in 2003 with the honorary doctorate “Ayurveda Acharya” (Ayurvedic Institute Asthavaidyan Thaikat Mooss’ SNA Oushadhasala, India), and Professor of Ayurveda at the Master course in “Health Systems, Traditional and Non Conventional Medicine” University of Milano-Bicocca, Italy. He is Member of Non Conventional Medicines Committee of the Medical Council of Milan Province.

Dr. Sintija Sausa Chandravali, Faculty of Medicine, University of Latvia, Riga, Latvia., Internal medicine specialist. Works at the University of Latvia, Faculty of Medicine, department of Internal medicine. Also work at the Emergancy Medicine center at the Pauls Stradiņa Clinical University Hospital.

Dr. Anupama Kizhakkeveettil is an ayurvedic practitioner, licensed acupuncturist and certified yoga teacher. She graduated in Ayurvedic Medicine from Mangalore University in India, received a Masters in Acupuncture and Oriental Medicine from Southern California University of Health Sciences (SCU) and her Ph.D. from Walden University. She is currently the Program Director for Ayurvedic Medicine and provides clinical services for SCU Health System. In her clinical practice she integrates diet, yoga, lifestyle counseling, herbs and various body work therapies individualized to patient’s condition. Her main interests are managing musculoskeletal condition, mental health, women’s health and preventative care. Dr Sandeep Nair works at Evangelisches krankenhaus and studied at Govt Ayurveda College Trivandrum. Research Assistant Dept of Neurology EVK Hattingen Germany. Practicing Ayurveda Medicine in Germany since the last 5 years with Prof. Horst Przuntekh who is an eminent Neurologist researching on Ayurveda. The Department of Neurology at EVK Hattingen is investigating the benefits of Ayurvedic interventions in management of chronic Neurodegenerative diseases.

Prof. Ravi Mehrotra is the Director at the National Institute of Cancer Prevention and Research (Indian Council of Medical Research) of the Dept. of Health Research at Noida and WHO FCTC-Global smokeless tobacco products hub . He completed his medical training at the prestigious Armed Forces Medical College, Pune followed by MD and Ph.D. at the University of Allahabad and Fellowship of the Royal College of Pathologists. He did his postdoctoral training at various advanced centres around the world including Johns Hopkins Medical Center, Baltimore and University of Pennsylvania Medical Center.

Dr Gangadhar is a professor of psychiatry at NIMHANS and was the dean of behavioral sciences before taking over as director. He was the recipient of Sir CV Raman Award in 1999, and the BC Roy Award in 2010, both from the Karnataka Government. His areas of research interest include electro- convulsive therapy, neurobiology and treatment related aspects of schizophrenia, and yoga and its application in mental health. He is also the program director at the Advanced Center for Yoga at NIMHANS.

Book of Abstracts 31 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Dr. Manoranjan Sahu, Faculty of Ayurveda, Banaras Hindu University, Varanasi with expertise in Surgery.Prof. Sahu is a well known surgeon of ano-rectal diseases having expertise in Chhar Sutra technique. Presently Prof. Sahu is Coordinator of National Resource Centre for Chhar Sutra. He joined Ayurveda Faculty as Reader in 1993 and served the Shalya Tantra as head on 3 occasions. Prof. Sahu has also worked as Professor In-charge of Ayurveda wing of Sir Sundarlal Hospital of BHU. Prof. Sahu has the credit of publishing more than 35 research papers at international level.

Dr. Shantikumar Nair is the Dean of Research to Amrita Vishwa Vidyapeetham (University), and also the Director of Amrita Centre for Nanosciences and Molecular Medicine (ACNSMM), Health Sciences Campus. Dr. Nair received his Bachelor of Technology degree in Metallurgical Engineering from the Indian Institute of Technology, Bombay, India, in 1976; Master of Science (1978) and Doctor of Engineering Science (1983) degrees in Materials Science and Engineering from Columbia University, New York, USA. He joined the faculty of the Mechanical Engineering Department of the University of Massachusetts, Amherst, MA, USA, in 1985 In 2006, he joined Amrita University. Dr. Shivenarain Narsinghlal Gupta, Professor and Head of Department of Kayacikitsa ( PG) & Hospital Superintendent, J.S. Ayurveda college, Nadiad (Gujarat), India. He is Academic and scientific Advisory Board, European Academy of Ayurveda, Germany. Since June 1982 associated with P.D.PATEL AYURVEDA HOSPITAL, NADIAD as Physician and achieved remarkable success in the management of the diseases of chronic and obstinate nature including the diseases of kidney, liver and heart with research oriented classical approach. Evaluation of efficacy of Ayurvedic therapies on Bronchial asthma. Clinical trials on Diabetic nephropathy and Diabetic Neuropathy. Evaluation of Vardhamana pippali (long pepper) in the patients of autoimmune diseases.

Dr. Arvind Kulkarni, Director, Oncology Integrated Cancer Treatment and Research Centre, Pune and Ex- HOD, Radiation Oncology Department, Bombay Hospital is accompanying us for the conference. He is a well-known senior oncologist in Pune and Mumbai as well as a strong believer of alternative medicine and Ayurved. He completed his Masters in Radiation oncology in USA and was practicing as Radiation Oncologist at USA for many years. He is a writer of a book "War Against Cancer"

Dr. Narendra S. Bhatt, M. D. Ayu. & B. Sc. from the University of Bombay has behind him 40 years of teaching, clinical, research and pharmaceutical experience. After 11 years of teaching & clinical experience he joined industry. Over a period of 21 years in various capacities he rose to become CEO of Zandu Pharmaceuticals, one of the oldest & largest Ayurvedic production organizations in the country. Having keen interest in research he has evolved and developed unique models for product development and clinical research. He at present is Adjunct Professor & Director for Research to College of Ayurveda, Bharati Vidyapeeth University, Pune.

Dr. N. Dinesh did his undergraduation from Calicut Medical College, DPM from B.J.Medical College, Ahemadabad, Gujarat and MD from Govt. Medical College, Baroda, Baroda University. Before joining Amrita Hospital, he worked as a Consultant Psychiatrist and DipN.B. Faculty in Kochi, as Consultant Psychiatrist in Medical Centre, Palarivattom. He is offering his services in Amrita Hospital since 2003 and his areas of interest are general adult psychiatry, deaddiction, consultation liason psychiatry and geriatric psychiatry.

Book of Abstracts 32 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Dr. K. Pavithran currently serves as Professor and Head of the Department of Medical Oncology and Hematology at Amrita Institute of Medical Sciences. He took his MD in Internal Medicine from Calicut Medical College and DM in Medical Oncology from Kidwai Memorial Institute of Oncology, Bangalore. He is a Fellow of the Royal College of Physicians, London. He had his training in hematology from the Royal Hallamshire Hospital, Sheffield, United Kingdom and gained experience in bone-marrow transplantation from Fred Hutchinson Cancer Centre, Seattle, USA. He is member of many natioanal and international associations.

Dr. Gopakumar MD (Ay) is currently working as an Associate Professor in the Department of Roga Nidana in Govt. Ayurveda College, . He is a resource person in many academic and research committees and has several publications and presentations in national and international seminars to his credit. A great scholar and orator in the field of Ayurveda, he is a prominent figure in various scientific seminars and presentations in Ayurveda in India and overseas. Dr S.Gopakumar received best Ayurveda teacher award on national Ayurveda day from Ministry of AYUSH.

Dr. L. Mahadeven MD (Ay) is Director of Y. Mahadeva Iyer’s Sri Sarada Ayurvedic Hospital and Associate Professor at Kayachikitsa Department, Pankajakasthuri Ayurveda Medical College, Killy, Kattakada, . Dr. L. Mahadevan received "Best Doctor Award - 2012" at The Dr. MGR Medical University, Chennai on 2nd April 2012 from Dr. V.S. Vijay, Honorable Health Minister, Govt. of Tamilnadu. Studied clinical application of the science. Under the guidance of Late. Shree.Dr. B. Vaidayanathan Siromani, Principal, Venkataramana Ayurveda College. Chennai. Studied in his clinic in the traditional manner for 4 years.

Dr. Gireesh Kumar K. P. is a Professor of Internal Medicine at Amrita with special interest in the area of emergency medicine. A pioneer in the field of emergency medicine in India, he set up the first emergency medicine specialty in Kerala. He is trained in the management of all major medical emergencies and acute trauma cases. He has also authored eight well-known books in the field of internal medicine / emergency and critical care medicine. He has special interest in management of snakebite cases and infectious diseases/ HIV and sepsis cases and has teaching experience of more than 10 years. Dr Rama Jayasundar is one of the most erudite, articulate and widely travelled ambassadors of ayurveda today. She acquired her PhD in NMR (Physics) from Cambridge University, UK, in 1990 and has been on the faculty of All India Institute of Medical Sciences (AIIMS) since 1993. Between 2002 and 2008, she took 5½ years leave from AIIMS to pursue a BAMS (Bachelor of Ayurvedic Medicine and Surgery) degree from Chennai. Her area of specialization is Biomedical NMR – Radio- frequency (RF) coil designing and building, RF pulse sequence programming, clinical imaging and spectroscopy, Neuroscience applications of MR. Dr Sanjeev Rastogi is MD in Kaya Chikitsa (Ayurvedic medicine) from Banaras Hindu University, Varanasi with an exceptional carrier. He additionally posses a diploma in Yoga, a certification in acupuncture from China, a PG diploma in health and hospital management from IGNOU and an entitlement for green ( GHC) leadership from Teleosis institute , USA. In recognition to his work, he is awarded with a Chinese Govt. fellowship in 1998, Luisa Kreisberg Family Foundation Scholarship 2008 from Teleosis Institute , California , Consumer Wellness Center Nutritional Grant Award consecutively for 2 years in 2008 and 2009 from CWC, Arizona, USA and Robert Bosch foundation sponsorship to attend CAM summer school in Pots dam , Germany in 2010

Book of Abstracts 33 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Dr. Jayakumar R. is a Professor at the Center for Nanosciences and Molecular Medicine (ACNSMM), Amrita Vishwa Vidyapeetham, Kochi-682041, specializing in the area of Biopolymeric Nanomaterials. Dr. R. Jayakumar joined ACNSMM in November 2007. He received his Ph. D. in Polymer Chemistry from Anna University, Chennai, India (2002). He has over 215 Journal publications, 8 book chapters and 10 patents to his credit. His publications have been cited more than 10200 times with h-index-53. Recently Dr. Jayakumar received “Best Faculty Researcher Award” from Indian Chitin and Chitosan Society (ICCS). Dr. Krishnakumar Menon graduated with an M. Sc. in Biochemistry from M. S. University of Baroda, India, and also with an M. Sc. (Prelim, Monash)/Ph D on a scholarship from National Multiple Sclerosis Society of Australia equivalent to commonwealth research grant from La Trobe University, Australia. He then went on to do his post-doctoral training on a JSPS fellowship at the National Institute for Physiological Sciences, Japan, and University of Connecticut Health Center, USA. Subsequently, he joined as a staff scientist at the University of Iowa, USA, and Monash Immunology and Stem Cell Laboratories at Monash University, Australia, before joining the faculty at Amrita.

Dr. Harish Kumar, MD, MRCP is Clinical Professor and Head, Centre for Endocrinology and Diabetes, Amrita Institute of Medical Sciences, Kochi, Kerala. His main areas of research are diabetic foot and thyroid disease. he has two patents to his credit. instrumental in setting up the department of endocrinology, diabetes and podiatric surgery at the Amrita Institute of Medical Sciences, Kochi. He has 56 publications in National and International journals and Founding editor of Amrita Journal of Medicine. Has a keen interest in patient education and has set up an organization called Amrita Diabetic Welfare Association Dr. Anand Kumar took his MBBS and MD [General Medicine] from Medical College, Trivandrum. He did his post-doctoral training in Neurology at the Sree Chitra Tirunal Institute for Medical Sciences and Technology. He later joined as faculty in Trivandrum Medical College. In 1989, he joined the Ministry of Health, Sharjah as specialist Neurologist. He established the Department of Neurology at Al Qassimi and Kuwait Hospitals, Sharjah. He relocated to India in 1999 and joined the Amrita Institute of Medical Sciences. He works on memory, autonomic function studies, dysarthria, patient monitoring, life style modification, space-mind medicine and epilepsy prediction.

Dr. Shyam Diwakar is the Lab Director of Computational Neuroscience and Neurophysiology Laboratory, a Faculty fellow at the Amrita Center for International Programs and an Associate Professor at the School of Biotechnology. He is the Institute Integration Coordinator and Co- investigator of VALUE (Virtual and Accessible Laboratories for Universalizing Education); a major virtual labs initiative supported by Sakshat mission of MHRD, Government of India, and Principal Investigator of few other projects funded by Department of Science and Technology.

Dr. Vineeta Deshmukh, M.D., Ph.D., Deputy Director, Integrated Cancer Treatment and Research Centre, Pune has been engaged with ocumentation and treatment of cancer patients of various sites, stages and grades with Ayurved under the guidance of Dr. S. P. Sardeshmukh, Ayurvedic physician and Dr. Arvind Kulkarni, Radiation oncologist since 1996. Treated more than 7000 cancer patients with integrated and holistic approach which includes Shamanachikitsa, Panchakarma, Diet therapy and counseling.

Book of Abstracts 34 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Dr. Ramesh R. Varier graduted from Coimbatore brings with him a rich experience spanning over 25 years of suc- cessful Ayurvedic clinical practice. Keenly interested in integrating mod- ern scientific principles with traditional Ayurvedic concepts, Dr Ramesh has been highly successful in establishing comprehensive healthcare solu- tions for a variety of chronic diseases. He headed the team that Successfully converted traditional Ayurvedic formulations called Kashayams (Liquid extracts) into tablets and launched the same in the market. He is Engaged in developing integrated understanding and specialized Ayurvedic treatments for a range of chronic ailments.

Dr.C Suresh Kumar is a specialist in marma chikitsa working as the Managing Partner and Chief Physician of Triveni Nursing Home, a 75 bed multi-specialty hospital at Trivandrum, Kerala. He has presented around 38 scientific papers in both National and International levels. He received the Best clinician AVP achievement award at International grand Centennial Convention on Ayurveda 2008.

Dr. Supriya Bhalerao MD, PhD (Ayu), PG Dip in Bioethics.Dr. Supriya Bhalerao is currently working as a Scientist at Interactive Research School of Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Pune. Before joining IRSHA in July 2013, she had a long tenure of 15 years as a Research Officer at Dr. Sharadini Dahanukar-Advanced Centre for Ayurveda Research, Training and Services, Department of Clinical Pharmacology, Topiwala National Medical College & BYL Nair Ch. Hospital, Mumbai.

Dr. Girish Tillu, MD, is trained in Ayurvedic medicine, and is pursuing research at the Interdisciplinary School of Health Sciences, Savitribai Phule University of Pune, India. He worked as a scientist at the Center for Development of Advanced Computing, Pune and was instrumental in the development of the innovative software suite, AyuSoft, which is a decision-support system based on logic, and knowledge base of Ayurveda. He is involved in the study of Ayurveda and Yoga through interdisciplinary approaches comprising epidemiology, clinical pharmacology, and informatics. He is a recipient of the Vaidya Scientist Fellowship.

Dr. G. Geethakrishnan, MD (Ay) Geetha Krishnan is an Ayurvedic Physician with post graduate degree in Clinical Pharmacology of Ayurveda. He is presently the Head and Senior Consultant for Integrative Medicine at Medanta. Medanta is a group of hospitals offering high-end tertiary care services, indulges in quality clinical research & education activities, and runs a group of advanced clinical facilities in India and abroad. He also engages himself in botanical drug research and has passionately followed-up various drug development programs since 1999, working with Innoveda as its Founder, Indian Institute of Integrative Medicine (IIIM), Jammu.

Dr. M. Vijayakumar, MD (General Medicine) DNB (Medicine) DM (Cardiology) Fellowship Cardiology Thorax Center Rotterdam. is Clinical Professor at Centre for Aortic Diseases and Marfan Syndrome, Adult Cardiology, Heart Transplantation. Areas of interest includes Adult Interventional Cardiology. Endovascular Aortic Aneurysm Repair including Hybrid Aortic Stenting, Coronary intervention. He has special interest in Research on Atherosclerosis as well as dietary oil and coronary artery disease. He has vast experience in conducting clinical trials.

Book of Abstracts 35 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Dr. Prakash Mangalasseri, MD (Ay) is Associate Professor, Dept. of Kayachikitsa, Ayurveda College, , Done his graduation from Kottakkal and PG from Gujarath Ayurveda University with high academic credentials (Top rank holder & gold medalist for both BAMS & MD). He was declared as best outgoing student by Kerala Ayurveda Pharmacy in 1998 and his research thesis selected for Best Thesis Award in 2002 by Pune Academy of Ayurveda. He was invited speaker on “Pain management in Diabetic neuropathy” in 2nd Ayush International Conference held at Harvard Medical School, Boston USA in May 2017. He has also presented papers at other conferences in USA and China

Dr. Syam Unnikrishnan, M.D (Internal Medicine), D.N.B (Neurology), MNAMS (Neurology), Post Graduate Degree in Palliative care (Cardiff University, UK) is Head of the Department of Neurology, at Employees State Insurance Corporation of India Super- Specialty & Model Hospital, Asramam, Kollam, Kerala-691002, India since Nov 2012, which is under the Ministry of Labor and Employment, Government of India.

Dr. Pawan Kumar Godatwar , MD (Ay) and PhD from Gujarat Ayurveda University, Jamnagar and presently Associate professor and HOD of Roga Nidana and Vikriti Vijnana (Clinical and laboratory Medicine) in the National Institute of Ayurveda, Jaipur. Editor of the Journal of Ayurveda and author of 6 books and more than 30 national and international papers. He is a fellow of WHO (Diploma in STD/ AIDS, Thailand) and was an expert Member, Govt. of India Delegation to South Africa. He is the recipient of International Academy of Ayurveda Physicians- MADHAVA RATNA Award, 2010 and Recipient of “PURUSHOTTAM SHASTRI NANAL –CHARAKA” Award, Khadivale Vaidya Research foundation, Pune, 2013. Dr. M.R. Vasudevan Nampoothiri, MD (Ay) is Principal of Amrita School of Ayurveda, Amrita University, Kollam. He has 36 years of clinical and teaching experience. He served as Principal, Government Ayurveda College, Trivandrum and as Director of Ayurvedic Medical Education, Kerala. He was also State Program Manager, National Rural Health Mission. He received the Good Service Entry from . He has also received many other Awards for his contributions. He has visited nine countries including USA, Canada and Germany. He is Advisor to CCRAS and Executive Member of CCIM

Dr. P. Ram Manohar, MD (Ay) is Research Director at Amrita School of Ayurveda, Amrita University. He is Research Advisor to Indian National Science Academy and Member of Scientific Advisory Group of Central Council for Research in Ayurvedic Sciences. He has experience in Clinical Trials and Drug Development Research with a focus on Integrative Health Care and Medicine. He is a former member of Central Council for Indian Medicine. He regularly visits USA, Europe, Latin America and Russia for educational programs and research collaborations in Ayurveda. He served as Editor in Chief for hte largest PubMed indexed research journal on Ayurveda - Ancient Science of Life.

Dr. Rajmohan Velayudhan Pillai is Assistant Professor at Government Ayurveda College, Thiruvananthapuram. Completed BAMS and MD (Bhaishajya Kalpana) from Government Ayurveda College, Thiruvananthapuram. Started career as Medical officer in Indian systems of Medicine followed by Research Officer at the Drug standardization Unit, Government Ayurveda College, Thiruvananthapuram. Teaching career started at Vaidyaratnam P S Varier Ayurveda College, Kottakkal and later to the current office. He is recipient of SKM Research Scholar 2010 Award.

Book of Abstracts 36 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Dr. C. Raveendranatha Kamath is qualified in both Ayurveda and Modern Medicine. He has been practicing Integrated Medicine for eleven years at Amrita Instittue of Medical Sciences, Kochi, Kerala. He is the Head of the Centre for Integrated Medicine and Research at AIMS, which was established in 2015. He has been collaborating with Centre for Nano Scieneces and Molecular Medicine and Amrita College of Pharmacy guiding and providing research leads for doctoral and post doctoral students.

Dr. Sanjay Pisharody, MBBS- BJ Medical College, Pune, India, MD- Acupuncture (Hong Kong) Fellowship in Palliative Medicine- , Diploma in Palliative Medicine- Cardiff University, Scholar in Residence- Sandiego hospice - University of California. He is founder and director of Purnarogya Holistic Health Care, an organization dedicated to spreading the authentic principles of healing.

Dr. Pooja Sabharwal, MD (Ay), PhD is Assistant Professor, Rachna Sharira (Ayurvedic Anatomy), Ch. Brham Prakash Ayu Charaka Sansthan, New Delhi, Govt of India. Invited by Embassy of INDIA, STOCKHOLM, SWEDEN in Seminar “Principals & concepts of India Traditional Medicine-Ayurveda in Riga on 21st March 2014, the event Co-organised by Indo Baltic Federatia of Culture & Commerce. She has been deputed by Govt. of India to many countries for the propagation and promotion of Ayurveda.

Dr. Vijith Sasidhar is the founder of Sreekrishna Ayurveda Chikitsa Kendram, in Kerala, India. He is an exceptional Ayurvedic physician and teacher. Since 2005 he has been running the clinic together with his wife, Dr. Vidya Vijith. He is faculty at Academy of Ayurvedic Studies in Netherlands. He obtained his Ayurvedic degree from Rajiv Gandhi University of Health Sciences. He underwent many years of Gurukula training under Brahmasri Vallur Sankaran Namboothiri, an expert in Ayurvedic toxicology and Astangahridayam.

Dr. Uma Shankar Prasad, MBBS, MD (Internal Medicine), DNB, MPhil, BAMS is Consultant Internist at Sunshine Hospitals, Secunderabad. He studied Ayurveda after obtaining higher qualifications in modern medicine and has been exploring the areas for integration of Ayurveda and Modern Medicine in his own clinical practice. He worked as Consultant at Dept. of Internal medicine & Critical care ; Care Hospitals, Hyderabad and as Assistant Professor of Medicine at Gandhi Medical College.

Dr. Adriana Elaskar is Medical Surgeon, graduated from the National University of Cordoba. U.N.C. Argentina, Diploma in Public Health, School of Public Health of the U.N.C. Argentina, Specialized in: Paediatrics, Child and Adult Psychotherapy, Ayurveda Medicine. President of the Villa Luz Foundation for Human Development and Quality of Life, a non-profit institution. Academic Director of the Argentine Ayurveda School.

Book of Abstracts 37 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Prof. Dr. Anand Chaudhary is Professor Department of Rasa Shastra (Ayurvedic Pharmaceutics), Faculty of Ayurved, Institute of Medical Sciences, Banaras Hindu University, Varanasi– 221005 INDIA. He is Expert Member; ASIIA, Monitoring Group, Principal Scientific Advisor, GOI, New Delhi. Expert Member ; Traditional Knowledge Digital Library, Government of India, Research Advisor, CCRAS. Has vast experience in Pharmaceutical Research and has presented papers in India and abroad in many conferences. He has about 86 publications to his credit.

Ashtavaidyan A.N. Narayanan Nambi, MD (Ayu) is the successor of a great lineage of Ashtavaidyas, or the Ayurvedic families of Kerala. He is recognized in both in India and in Europe for his knowledge of Ayurveda and Indian sciences. He is actively involved in Ayurvedic education in Europe and Middle-East. His teachings and articles have received much acclaim in both India and the West. Currently Dr. Nambi is Director of Academic and Clinical Services of the SNA Oushadhasala (P) Ltd founded by Ashtavaidyan Thrissur Thaikat Mooss.

Dr JLN Sastry, MD (Ayu) Dr. J.L.N. Sastry, currently designated as the Head of Healthcare Research in Dabur Research & Development Centre, Sahibabad, is a distinguished Ayurvedic Physician and Researcher. Involved in teaching and has held various administrative positions in government institutions. He was also associated with Dabur India Ltd earlier as Medical Advisor and as Head, Clinical Research.

Dr. C. Gopimohan, is Incharge, Bioinformatics and Computational Biology laboratory at the Center for Nanosciences and Molecular Medicine, Institute of Medical Sciences and Research Centre, Amrita University, Kochi. He obtained Ph.D. degree from Banaras Hindu University, Varanasi. He gained experience as a postdoctoral fellow from the Molecular Biophysics Unit at the Indian Institute of Science, Bangalore, and as a Research Officer from the Department of Biology and Biochemistry, University of Bath, United Kingdom. Further, he worked as an Associate Researcher of CNRS in Laboratoire de Cristallographie, and Modelisation des Materiaux Mineraux et Biologiques, University Henri Poincare, Nancy, France. During his research career, he visited different countries which include: UK, Canada, France, Finland and USA.

Book of Abstracts 38 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Abstracts of Invited Talks

Integrative Oncology: An Effective Approach For Better Cancer Care Prof Abhimanyu Kumar, Director, All India Institute of Ayurveda, New Delhi

All India Institute of Ayurveda (AIIA), New Delhi in collaboration with National Institute of Cancer Prevention & Research (NICPR-ICMR) and National Cancer Institute, All India Institute of Medical Sciences (NCI-AIIMS), New Delhi; has established a ‘Centre for Integrative Oncology’ for teaching, training, research and networking of AYUSH experts working in the area of cancer care with the technical support of conventional Oncologists. The purpose of integrative approach of this center is based on the goals like, treatment of the cancer, prevention of recurrence, reducing side effects and symptoms. Ayurveda approach offers an unique blend of diet, physical activities, medicinal plants, Ayurveda formulations and Panchakarma therapies for helping cancer patients. Ayurveda encourages and prescribe the way to live a healthy lifestyle to help the body in its' innate abilities to fight and prevent cancer. Integration of Ayurveda approach and Yoga techniques with conventional treatment will provides better hope to cancer patients. The ultimate target is to utilize best from the two systems for betterment of patients. Presentation during the conference will provide the opportunity to share the views in the area of Integrative oncology.

Integrative Approach To Complementary Baby Feeding Dra Adriana Elaskar, Medical Director, ESCUELA AYURVEDA ARGENTINA, Fundación Villa Luz para el Desarrollo Humano y la Calidad de Vida

In an approach from Integrative Medicines, the nutritional principles of Ayurveda are revised in the light of scientific advances. Since health is determined primarily by the habits learned in the early years, adapted patterns of complementary feeding of the baby are proposed. These early-acquired habits help maintain or recover health from childhood and at all stages of life. It is proposed to orient the parents taking into account the singularity of each baby and its circumstances. It also seeks to clarify issues related to natural nutrition for achieving a balanced diet. This is the integrative contribution of Ayurveda medicine to Western medical science.

Safety Of Ayurvedic Formulations Including Drug Herb Interactions Prof Anand Chaudhary, Department of Rasa Shastra & Bhaishjya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi –India 221005

Ayurvedic formulations are safe for global humanity on virtue of its quality, safety and efficacy incurred therein after adaptation of basic fundamentals of Ayurvedic pharmaceutics quoted in classics of Ayurveda since thousands of years of its practice. In contemporary period, Ministry of AYUSH, Government of India has notified leading laws about Good Manufacturing Practices, quality standards of Ayurvedic formulations in Ayurvedic Pharmacopiea of India to ensure safety of these formulations. Pioneer institutions of India and abroad are conducting safety studies of Ayurvedic formulations and all these scientific studies are continuously being published in journals of repute. Drug –Herb interactions are point of concern among all stakeholders of health and especially among believers of integrative approach of clinics. Salient studies are indicating a caution about synergistic or antagonist therapeutic effect of Ayurvedic formulation when these are prescribed simultaneously with a drug of different system of medicine to a single patient. Details of these studies at Banaras Hindu University and at several academic organization would be presented during Amrita Samyogam.

Book of Abstracts 39 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Integration Of Allopathy And Ayurveda For Neurological Disorders Dr. Anand Kumar, Amrita Institute of Medical Sciences, Kochi, Kerala, India

There are about forty neurological disorders where integration is between the two systems of medicine possible.Clinical studies and case based approaches have been published in literature. In comparison to the vastness of the two systems studies have been far and few. While doing data mining I hit upon a study where healthy volunteers were studied. In fact that study took me to my dream project- Amrita wellness program. This program was designed to integrate Allopathy, Ayurveda, Yoga, Meditation, Ergenomics, Sleep hygiene. and medical astrology. Integration for positive health needs to be promoted as a movement rather than a clinical study. Wellness of children should be our aim. Another subject I would like to dwell upon is the study of heart rate variability, respiratory rate variability, heart and lung evoked brain potentials for proving that Yoga and Meditation do work in achieving internal resonance coherence. Each individual has a resonance frequency that needs to be in tune with the resonance of the Universe. The presentation will a right brain approach of the whole rather than going into details of individual diseases.

Promoting Mental Health In Chronic Disease: The Advantages Of An Integrated Perspective Prof. Antonella Delle Fave, University of Milan, Milan, Italy

In Western medicine, attention to mental health as a component of health as a whole is a recent acquisition, despite repeated WHO claims and the formalization of the bio-psycho-social model. Mental health is usually assessed as absence of affective or cognitive disorders, while the positive components of psychological functioning were only recently identified and measured. Related studies highlighted the usefulness of this approach, showing that positive mental health is a substantial asset to be preserved and promoted in chronic disease conditions, currently representing an epidemiological challenge worldwide. Ayurveda, with its view of health as a unitary psychophysical process, can be especially helpful in designing integrated interventions addressed to people diagnosed with chronic and degenerative diseases entailing long-term disabilities. The contribution of Ayurvedic interventions to the treatment of these conditions should therefore be assessed through both biological and psychological outcomes, representing structurally interconnected and mutually influencing dimensions of health.

New Insights From Ayurveda Reading Of Neurological Diagnostic Tests Dr. Antonio Morandi, MD, Ayurvedic Point, Milan, Italy

The conceptual framework in which nature and science are interpreted depends on historical, cultural, social and economic factors. The concept of the modern biomedical model expressing the Health/Disease opposition is based on elements which have characterized the history of Western civilization where discontinuity has been privileged over continuity, leading to a system centered on the juxtaposition of two theoretical opposites. This fostered the emergence of clear categories that, especially in the biomedical disciplines, have been useful to clearly describe structures and organization of the living beings. On the contrary, Ayurveda is developed within Indian Tradition, rooted in the perspective of interconnectedness which is a factor indeed favorable to a synthetic vision and an holistic perspective of the dynamics of living systems. This justifies the inclusiveness underpinning Ayurveda epistemology. However Nature is one notwithstanding the human diverse viewpoints, and a complete picture will derive only from the integration of multiple perspectives. Here we propose the utilization of Ayurveda epistemology to interpreter the diagnostic data obtained with biomedical logic and tools in order to overcome the limitations of culture bound models and to explore the potential of a novel complex and multidimensional view of

Book of Abstracts 40 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine biomedical as well as scientific research. We will explain this new concept applied to the neurological field.

Integrative Medicine: Protocols For Clinical Research Dr. Anupama Kizhakkeveettil, Southern California University of Health Sciences, Los Angeles, USA

According to National Institutes of Health, definitions of Integrative Medicine include bringing conventional and complementary approaches together in a coordinated way. Recognition of the value of Integrative Medicine for patient care has grown tremendously across the world. Integrative Medicine makes use of appropriate therapeutic approaches and collaboration among health care professionals to provide patient care aimed at achieving optimal health and wellbeing. An evidence-based approach is important to achieve successful and timely implementation of this emerging paradigm in health care. There is a scarcity of research evidence about integrative medicine for the management of various diseases. The scope of research includes evaluation of the effectiveness of specific therapies, multi-modality whole system interventions, practitioner- patient relationships, and comprehensive evaluation of health and disease. This presentation describes the current state of the science of integrative medicine and clinical research protocols.

Need For Integration In Oncology Dr. Arvind V. Kulkarni, MD, D.M.R.D.(Eng), D.A.B.R.(USA), Director Oncology, ICTRC- Integrated Cancer Hospital, Wagholi, Pune, India, www.ayurved-for-cancer.org

Based on our research records and observations on 10,904 biopsy proved cancer patients in our cancer project in the past 22 years since 1994, our team has been developing Integrative Model for Cancer with Ayurved supplementing Modern Medicine. Our Integrated Cancer Hospital in Pune is declared as “ Centre of Excellence” by AYUSH Ministry of Health. Suffering in cancer patients is more due to aggressive tissue destructive treatments, neglecting to support healthy physiology and psychology. Ayurved and other AYUSH Methods compliment judicious use of Modern Medicine, at all stages of cancer. Integrative Macro-management of cancer is more beneficial than micro-analytical pharmaceutical approach. Our medical team would present some research papers to support these observations to this August meeting at AMRITA UNIVERSITY.

Comparative Effectiveness Of Ayurveda And Conventional Care In Knee Osteoarthritis - A Randomized Controlled Trial Christian S Kessler (MD, MA)1,2, Kartar S Dhiman (Professor)3,4, Abhimanyu Kumar (Professor)3,5,Thomas Ostermann (Professor)6, Shivenarain Gupta (Professor)7,8, Antonio Morandi (MD)9, Martin Mittwede (Professor)7,10, Elmar Stapelfeldt (MA)2, Michaela Spoo (MD)2, Katja Icke1, Andreas Michalsen (Professor)1,2* Claudia M Witt (Professor)1,11,12* 1Institute for Social Medicine, Epidemiology and Health Economics, Charité Medical University, Luisenstr. 57, 10117 Berlin, Germany, 2Immanuel Hospital Berlin, Department for Complementary Medicine, Königstr. 63, 14109 Berlin, Germany3Ministry of AYUSH, AYUSH Bhawan, B Block, GPO Complex, INA, New Delhi 110023, India , 4Central Council for Research in Ayurvedic Sciences (CCRAS), Jawahar Lal Nehru Bhavan, No.61-65, Institutional Area, Janakpuri, New Delhi 110058, India 5All India Institute of Ayurveda, Mathura Road, Gautampuri, Sarita Vihar, New Delhi 110076, India, 6University of Witten Herdecke, Department of Psychology and Psychotherapy, Alfred-Herrhausen-Straße 50, Witten, Germany7European Academy of Ayurveda, Forsthausstr. 6, 63633 Birstein, Germany, 8Department of Kaya Cikitsa, J.S. Ayurveda College & P.D. Patel Ayurveda Hospital, College Road, Nadiad 387001, India, 9Ayurvedic Point, School of Ayurvedic Medicine, Corso Sempione 63, 20149 Milan, Italy, 10University of Frankfurt, Department of Religious Sciences, Grüneburgplatz 1, 60323

Book of Abstracts 41 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Frankfurt, Germany, 11Institute of Complementary and Integrative Medicine, University Hospital and University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland, 12University of Maryland School of Medicine, Center for Integrative Medicine, 520 W. Lombard Street, East Hall, Baltimore, MD 21201, USA * contributed equally

Objectives: We aimed to evaluate the effectiveness of Ayurvedic treatment compared to conventional care in knee OA patients. Methods: Knee OA patients were included in a multicenter RCT in Germany. Patients received either Ayurvedic treatment (n=77) or conventional care (n=74) over 12 weeks. Primary outcome was the change on the WOMAC Index after 12 weeks (validated German version). Results: 151 patients (Ayurveda n=77, conventional care n=74) were included. Changes of the WOMAC Index from baseline to 12 weeks were more pronounced in the Ayurveda group (mean difference 61.0 [95% CI 52.4;69.6]) than in the conventional group (32.0 [95% CI 21.4;42.6]) resulting in a significant difference between groups (p<0.001) and a clinically relevant effect size (Cohen’s d 0.68 [95% CI 0.35;1.01]). Effects were sustainable at follow-ups after 6 and 12 months. Conclusions: Results suggest that a complex Ayurvedic treatment might be more beneficial in reducing subjective knee OA symptoms than a complex conventional intervention. Registration: clinicaltrials.gov (NCT01225133) Funding: AYUSH Ministry, India.

Methodology For Testing Ayurvedic Therapy In Rheumatoid Arthritis – Are We Ready? Daniel E Furst, MD, Prof. of Rheumatology at the University of California in Los Angeles, the University of Washington in Seattle, Washington and the University of Florence in Florence Italy.

Ayurvedic therapy has a 3000 year history but it is not fully accepted throughout the world. This acceptance can be accelerated by using the highest scientific standards of investigation. Ayurveda is an holistic individualized approach and requires consideration of multiple specific factors. Thus inherent patient characteristics and multiple treatment modalities including herbs, enemas, oils and diet must be considered. This results in a plethora of possibilities and presents difficulties when attempting to achieve uniformity for comparisons. There has been significant progress in this area, at least in rheumatoid arthritis. An observational trial and a double-blind, randomized, placebo-controlled pilot study has been completed. They have laid the background for proving the efficacy of Ayurvedic therapy by global standards. There needs to be standardized baseline diagnostic and characteristic description, multiple placebos, separation of dispensers from evaluators, standardized evaluation techniques, pre-specified analysis and, importantly, "buy in" by Ayurvedic physicians that this approach is both feasible and desirable.

Expanding Potential For Ayurvedic Therapy – The Case For Systemic Sclerosis Daniel E Furst, MD, Prof. of Rheumatology at the University of California in Los Angeles, the University of Washington in Seattle, Washington and the University of Florence in Florence Italy.

Systemic sclerosis is a multisystem autoimmune disease involving blood vessels, the immune system and fibrosis. It is an uncommon disease, affecting 300 – 700 patients per million. In its most severe form, it has a 50% five-year

Book of Abstracts 42 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine mortality. One of my systemic sclerosis patients feels she has improved significantly using classical Ayurvedic techniques. Based on this case report, one might consider the use of Ayurvedic therapy in systemic sclerosis. System sclerosis (scleroderma) is characterized by multiple manifestations .Raynaud's phenomenon (90% of patients) is a vascular phenomenon affected by the environment and stress. Skin thickening (98%) compromises quality of life and correlates with mortality. Treatments often require aggressive immunotherapy. Gastrointestinal involvement (90%) is nearly universal and leads to malnutrition and significant compromise in quality of life. Systemic sclerosis is an opportunity for Ayurvedic therapy to affect multiple aspects of a potentially devastating disease.

Biology Of Yoga Therapy In Mental Disorders: A Potential Objective Marker? Dr. B.N.Gangadhar, Senior professor of Psychiatry and Director, NIMHANS, Bangalore 560029

Biological basis of mental disorders is an extensively studied subject. Though the last word is not yet said, this has led to the understanding of the mechanisms of action of the treatments. For example, the antipsychotic effects of the drugs are mediated by the blockade of dopamine receptors. On a similar line, it is necessary to understand the mechanisms of action of the traditional systems of treatments. Such investigation has yielded results. Biological effects of yoga have been identified and some of these effects were correlated with therapeutic effects. It is however possible that these effects are perhaps epiphenomena and may not explain the correction of the pathophysiology of the disorder that is treated. Yoga has been effective in the treatment of depression, schizophrenia and even in elderly with mild cognitive impairment. The stress indicator, cortisol, drops in serum after yoga therapy. This effect correlated with antidepressant effects. Levels of brain derived neurotropic factor (BDNF) were lower in depressed subjects but increased following yoga intervention. Yoga also led to changes in brain directly. For example, in elderly with MCI, six months of yoga resulted in increases in hippocampal volume. In individuals with schizophrenia yoga resulted in facilitation of GABA function centrally. This was associated with enhancement of mirror neuron activity. In turn, this has been linked to improvement in social cognition. Some of these biological changes have been demonstrated in healthy subjects too. Individual components of yoga too have distinct biological effects. For example, OM chanting deactivated the limbic structures that is similar to vagus nerve stimulation. Some asanas have differential effects on the heart rate variability. Demonstration of a biological correlate helps in its use as an objective parameter to measure yoga effects. Also the understanding of the biology of yoga therapy provides ‘scientific support’ that is sought after by modern physicians to support integration of yoga (and perhaps other traditional methods) into main stream clinical practice.

Observations In Outcomes Research On Integrative MEdicine Geetha Krishnan G MD Ayurveda, Head of the Department of Integrative Medicine, Medanta- The Medicity Hospital, Gurugram, Haryana, India 122001, [email protected], www.medanta.org

Integrating Ayurveda in a modern medical therapeutic setting is beneficial, as evident from the outcomes data of seven years of Integrative medicine practice and research at Medanta- the Medicity hospital, a large tertiary medical care facility in India. Integrative medicine followed here involves judicious inclusion of Ayurveda (medicine, procedures, life conduct, diet, Yoga, and Panchakarma) to support the unmet clinical care need of a patient in tertiary care allopathic hospital. Thus, integrative medicine in its greater magnitude is a decision-making process, of deciding when, where, which, how and what to be brought together from different systems of medicine for the

Book of Abstracts 43 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine benefit of the patient. There are few diseases which have excellent or better clinical outcomes, when Ayurveda is used as the primary intervention, such as early osteoarthritis, low back pain, migraine, melasma, GERD, constipation, IBS, insomnia, etc to name a few. There are others when Ayurveda addition (to allopatic intervention) could bring incremental benefit to the patient, such as early atherosclerosis, brain stroke, Parkinson’s disease, Cancer care, post-surgical neuralgia, certain resistant viral infections, brain injury related minimally conscious states, vascular complications of diabetes, uncontrolled diabetes etc to name few other. This presentation aims to highlight few clinical areas worthwhile to be considered by medical providers, which Medanta data confirms to be useful to patients, when administered in an integrated fashion.

Holistic Approach To HIV Infection Dr. Gireesh Kumar, MD, Amrita Institute of Medical Sciences, Kochi, Kerala, India

HIV stands for human immunodeficiency virus. If left untreated, HIV can lead to the disease AIDS (acquired immunodeficiency syndrome).HIV attacks the body’s immune system, CD4 cells (T cells), which help the immune system fight off infections. HIV reduces the number of CD4 cells (T cells) in the body, making the person more likely to get infections or cancers. Over time, HIV can destroy full immune system that the body can’t fight off infections and diseases. These opportunistic infections or cancers take advantage of a very weak immune system and signal that the person has AIDS, the last state of HIV infection. No effective cure for HIV currently exists, but with proper treatment and medical care, HIV can be controlled. The medicine used to treat HIV is called antiretroviral therapy or ART. • Major problem of HIV infection in human body • Qualitative and Quantitative deficiency of T. Helper / Inducer cells (CD4 cells). • Reduction in CD4 count leads to low immunity. • Opportunistic infections can occur when the immunity is low. • When CD4 count falls ≤ 200 cells patient develop all types of opportunistic infections • AIDS defining diseases • Oesophageal candidiasis • Pulmonary / Extrapulmonary TB • Invasive cervical cancer, Kaposi’s sarcoma • Pneumocystis jirovecii pneumonia • Cryptococcal meningitis • Cryptosporidial diarrhea • CMV Retinitis • Disseminated Mycobacterium Avium infection • Extrapulmonary histoplasmosis / coccidiodo mycosis • Cerebral toxoplasmosis • CNS lymphoma • HIV – Dementia • Blood testing in HIV infection HIV Antibody Screening Test • HIV ELISA (Result will be available in 2 to 3 hours).It detects HIV antibodies in patients blood. It will be positive only after “window period”(Time between infection to antibody formation).It is highly sensitive (>99.5%) and specific CD4 COUNT • CD4 T helper cells are white blood cells that are an essential part of the human immune system. HIV reduces the number of CD4 cells (T cells) in the body. The normal CD4 range for HIV negative people is between Book of Abstracts 44 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

500 – 1600 cells/mm3.CD4 < 500 cell/mm3 should receive “HAART”. If CD4 is remaining more than 500 cell/mm3 and if there are no symptoms of AIDS patients may not require ART.If the infection is responding to treatment, there will be an increase of 100 to 150 cells/mm3 per year • Indications for starting Highly active anti retroviral treatment (HAART) • All patients with AIDS defining illness • All patients with CD4 < 500 cells/mm3 • How holistic medicine helps in treatment for HIV infected patients? According to Ayurveda, AIDS is primarily a disease of low immunity (ojas). Ojas provides the physical and mental strength to resist disease. With a lowered immune system the body is susceptible for opportunistic infections and disorders. There are millions of bacteria and viruses in our environment, many of which are contagious, that the body successfully fights off every day. But in a condition of low ojas, these organisms are allowed to remain in the body and cause opportunistic infections . Ayurveda has many highly effective therapies for improving the immunity. There is a branch of Ayurveda known as rasayana chikithsa, which specifically deals with increasing immunity and vitality through the use of various herbs, minerals and Ayurvedic practices. The line of treatment aims at the relief of current symptoms while addressing the underlying cause. After initial detoxification, the strength, immunity and vitality of the patient are increased through rasayanic therapies. Many patients with HIV infection with normal CD4 count will not require ART till the CD4 count drops less than 500 cells/mm3.In these type of patients ayurvedic medications may be helpful to improve their immune system so that the initiation of ART can be delayed.

‘P’ For Patterns: An Approach For Observational Research Exploring Clinical Data Girish Tillu, Center for Complementary and Integrative Health, Savitribai Phule Pune University, Pune, India – 411007 Email: [email protected] Phone: +91 985 002 6597

Increasing awareness about evidence based medicine (EBM) expects proof for Ayurvedic interventions. Most of the times the methods for evidence generation follow the approach developed for studying new chemical entities. The researchers expect ‘evidence’ while Ayurveda clinicians discuss ‘experience’. The cornerstone of EBM is trials, which follow generalized approach whereas Ayurveda advocates ‘personalized’ management. Other than foundations, research designs play an important role in widening the gap between research and practice of Ayurveda. The ‘hierarchical model’ considers randomized clinical trials as the most important study design and it is focused on hypothesis testing. Trials may have good internal validity but limited external validity. Considering the epistemological context of Ayurveda, proposed ‘circular model’ is more useful for better understanding of its interventions. This model uses multiple approaches employing strengths of observational study designs. The observational designs have good external validity but may limit internal validity and pose questions about risk of bias, confounders, and variability. The further approach for studying clinical data should be based on analysis of ‘patterns’ rather than evaluating ‘probability’. The trends generated by patterns can be confirmed using case series approaches where consistency, numbers and robustness can be verified prospectively in similar patient subsets. This approach can balance expectations for evidence and reshape clinical experience. However, precise documentation of clinical data with the rigor of a well designed trial is required for studying patterns. The pattern analysis of clinical data will provide insights for personalized management, Avasthik Chikitsa and reverting Samprapti to regain health (Pakritisthapan).

Book of Abstracts 45 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Ayurvedic Pathological Stages Of Parkinson’s Disease Dr.S. Gopakumar, MD – Roganidana, MD - Kayachikitsa, Associate Professor, Govt Ayurveda College, Thiruvananthapuram, Kerala, India

Parkinson’s Disease is a common neuro degenerative disorder prevailing in the current population across the globe. Despite the extensive researches on this field, a curative treatment for PD is still a mirage. Hence there is an increasing need for an integrative approach against this disease. Ayurvedic treatment principles may be helpful in relieving the discomfort of the patient and arresting the progression of the disease. Vyadhyavastha (Stage of pathology) is the different clinical conditions of the same disease. In the progression of this disease, there will be involvement of different Samprapthighatakas (Pathological factors) Being a chronic progressive disease, Parkinson’s disease will have variation in the degree of disease modifying factors at different stages of the disease. Precision in the assessment of Vyadhyavastha (stage of pathology) is very relevant to select appropriate drugs or therapy for the reversal of pathology. The vyadhyavastha of PD follows three stages which starts as kaphadhikatridoshaavastaha (Kapha dominant tridoshas stage) and ends with vathadhikatridoshavastha (Vata dominant tridoshas stage). In early stages, tridosha involvement is seen with predominance of kapha and vyana vayu. Rasa dhatu, sira, snayu, rasavaha, pureeshavaha and mutravaha srotases(channels) are involved. Decline of Agni is observed at jataragni and dhatwagni levels and Avarana (stage of obstruction) is the key event in pathogenesis. In the second stage, disease progress with additional involvement of mamsa (muscle tissue), medas (lipid component), asthi (bone), with their respective srotases, along with manovahasrotas (channel related with mind) and five divisions of vayu. Both dhathukshaya (tissue destruction) and Avarana coexisted in this stage and status of agni is vishama (uneven). In the third stage, all dhatus (tissues)and ojas (essence of all tissues) are involved. Dhathukshaya prevail over Avarana symptoms with a predominant vata vitiation. Hence the management of Parkinson’s disease should be based on the above mentioned pathological stages. In the initial phases, treatment for Avarana by proper panchakarma (bio purification) therapies, bahiparimarjana chikitsa (external treatments) and kapha vata pacifying drugs are needed. In the later phases rasayana (rejuvenation) treatments especially medhyarasayanas (rejuvenation of brain and mind) are of more importance with vata pacifying drugs.

Amrita Lepam-Universal Ayurvedic Bandage: A Technology Platform For Dermal Delivery And Therapeutics R. Jayakumar1*, Shantikumar V. Nair1* & P. Ram Manohar2* Centre for Nanosciences and Molecular Medicine, Amrita University, Kochi-682041, Kerala, India Centre for Advanced Research in Ayurveda, Amrita University, Kollam, Kerala, India E-mail: [email protected]; [email protected]; [email protected]

Centre for Nanosciences and Molecular Medicine developed a unique bandage for delivering ayurveda medicines in the form of oil and powder etc. The developed bandage is very flexible and has a macroporous structure. This bandage has ability to absorb 60 types of ayurvedic oils and deliver in a sustained manner to the skin. This helps to avoid using excess oil to the patients as well spreading to other area of the body. Even combination of ayurvedic oil and power in the mixed form also can be easily accomplished in the bandage. In addition this bandage has ability to prevent and protect from infection. This talk will provide information on preparation and encapsulation of ayurvedic oil/power. Application to patients will be discussed in detail.

Book of Abstracts 46 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Role Of Ayurveda In Cancer - Cure Or Care? Dr. Sastry J L N, Head - Health Care Research, Dabur Research & Development Centre, Sahibabad – 201010. (U.P.) [email protected]

Cancer Is One Of The Top Five Killer Diseases In The World. Owing To The Low Success Rate And High Cost Management, People Often Look At Alternative Therapies. The Treatment Related Side Effects Are Also Of Serious Concern. It Is Generally Believed That Ayurveda Has Several Remedies For Cancer Without Really Understanding Whether It Offers Cure Or Care? Review Of Ayurvedic Literature Suggest That Prognosis Is Of Prime Importance In Ayurveda. When One Explores Most Of The Cancer Conditions, They Fall Under Asadhya Lakshanas (Bad Prognostic Criteria) In Ayurveda. Therefore, While Managing Such Conditions, Risk Vs Benefit Analysis Is Essential. The Author Of This Paper Provided Ayurvedic Approach Towards Three Kinds Of Cancer Viz., Carcinoma, Sarcoma & Leukeamia Which Are Akin To Abhyantara - Madhyama - Madhyama Rogamargas. A Clear Approach Towards The Guidelines For Curative & Palliative Measures Is Made Along With Focus On Qol Improvement Measures.

Immunomodulatory Effects Of Herbal Extracts Of Ayurvedic Formulary (AF) On Immune Response And Its Implications In Multiple Sclerosis Krishnakumar N Menon, Centre for Nanosciences and Molecular Medicine, Amrita University, Kochi, Kerala, India, 682 041. Correspondence: [email protected],

Multiple sclerosis (MS) is an autoimmune neuro-inflammatory demyelinating neurodegenerative disorder affecting millions of people worldwide. Targeting autoimmune responses have been shown to have therapeutical significance for MS. Our studies have shown the significance of Glia Maturation Factor (GMF) expressed in astrocytes regulating the immune response in the central nervous system. GMF enhances the production of proinflammatory cytokines and that GMF-/- (null) mice failed to develop experimental autoimmune encephalomyelitis (EAE) due to diminished production of proinflammatory cytokines. Ayurvedic herbal extract AF has been shown to have an effect on regulating TNFα, IFNγ as well as the transcription factor NFκβ negatively. We therefore hypothesized that herbal extracts of AF could suppress the immune response generated by astrocytes. The aqueous extract of AF was tested for its ability to suppress the GMF expression. We found statistically significant suppression of GMF expression when treated with AF compared to control. These findings propose the significance of Ayurvedic formulary towards a new era of therapeutic approach in which biochemical basis of the drug effects can be evaluated.

Neurodegenerative Diseases: Early Intervention and Management Strategies Dr. L. Mahadevan, MD (Ay), Dr. Y. Mahadeva Iyer’s Sri Sarada Ayurvedic Hospital, Derisanamcope, Azhagiapandiapuram Post, Dist. – 629851

What are neurodegenerative diseases? υ Neurodegenerative disease is an umbrella term for a range of conditions which primarily affect the neurons in the human brain. υ Neurodegenerative diseases are difficult to manage and debilitating conditions that result in progressive degeneration of nerve cells.

Book of Abstracts 47 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

υ Examples of neurodegenerative diseases include Parkinson’s, Alzheimer’s, and Huntington’s disease. Causes • Genetic causes • Proteinopathies • Mitochondrial dysfunction Other causes like toxic burden of the body and inflammation. Ayurvedic perspective There is Kha vaigunya, agni dushti, mala sanchayam and dhatu kshayam So treatment protocol should include Agni deepana, sroto shodhana, medhya rasayanam and other selective ayurvedic procedures. Many of the neurodegenerative lakshanas like Kampam, spandanam, Sthambha, Sangnyanasham, Sphurana, Bala indriya upaghaata and Majja sosaarementioned in ayurvedic literature. Early intervention and diagnosis of diseases, early management, correct shodhana procedures, appropriate selection of medhya rasayana will not only prevent further deterioration of tissues but give a better management than modern system of medicine. This paper will enlighten over these areas. It also enlightens on specific drug selection for improving cognitive health, for treating involuntary movements and extrapyramidal features associated with neurodegenerative diseases.

Efficacy of Biodegradable Panchvalkal Scaffold in Management of Infected Wound Prof. Manoranjan Sahu, Professor, Department of Shalya Tantra, Former Dean, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India

Wound and its management has been a prime concern in Ayurveda since ancient times. Sushruta has written almost half of his treatise describing various aspects of wound healing. Panchvalkal, a compound drug obtained from barks of five plants of Ficus species, has been accredited to be useful in wound management at various stages in ancient texts. The drug was evaluated for its wound cleansing and healing properties and found effective in moderately infected wounds. To ensure a better drug delivery at the local site, a scaffold loaded with extract of panchvalkal was designed and evaluated for its efficacy. This presentation will deal with the drug delivery and efficacy of this novel device (scaffold) in the management of moderately infected wound.

Integration In Education: Cross-System Challenges Between Ayurveda And Medical Science Dr. Narayanan Nambi,

As Ayurveda being an indigenous system has many social, cultural and environmental bondages to India. It borrowed many ontological concepts, etymological means and philosophical frames from it’s sisterly systems like Nyaya, Vaisheshika etc. Hence, as a part of ayurvedic education it is very vital and integral to understand the view point not merely to get in the subject but to know the way of knowing. Though ayurvedic education started diffusing widely over many countries still the teachers of ayurveda need to re-think about this issue. It is vital to explain the socio-cultural linkage, environmental influences, food habits and even the religious and political implications at that time to have complete understanding of Ayurveda. Book of Abstracts 48 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Clinical Experiences in Cancer to Evolve Drug Research Approaches Dr. Narendra Bhatt, Bharathi Vidyapeeth, Pune

Recognized medical pluralism in India offers experiences of Ayurvedic practitioners in the treatment of Cancer. Most are of mixed types with variable outcomes. Such experiences of a private ambulatory practice in specific types of cancers with therapeutic approach explained will indicate the role Ayurveda can play. There exist variety of opportunities for Ayurveda in Cancer research. The drug discovery does remain most interesting and priority area in Cancer research. The drug discovery from Ayurveda is required to be understood in its own context for productive research activities. As Cancer is essentially a biomedical diagnosis that require integrative modalities for research. Clinical richness as in Ayurveda and huge therapeutic potential is required to be animated for specific targets. There is need to categorise therapeutic targets that form part present day drug therapy in addition to cancer specific solutions. A systematic approach to define therapeutic targets will help evolve right strategies that can provide specificity of the research process rather than anecdotal searches. Such a plan will help develop targeted roadmap.

Therapeutic approaches in Duchenne Muscular Dystrophy Nereo Bresolin, Director of the Centro Dino Ferrari, University of Milan, Italy

Duchenne muscular dystrophy (DMD), the most frequent childhood dystrophy affecting 1 out of 3,500 newborns, is caused by mutations in the dystrophin gene (DMD), which encodes for a cytoskeletal protein bridging extracellular matrix and cytoskeletal proteins. Although no effective therapy is currently available for DMD, several new therapeutic approaches have been proposed, whose definition strongly relies on a detailed knowledge of DMD pathogenesis and the downstream processes determined by dystrophin absence. These therapies include approaches that aim at expressing a functional dystrophin protein, such as readthrough strategies and AONs, and drugs modulating the downstream targets in the DMD pathogenesis, such as NO donors and histone deacetylase (HDAC) inhibitors. The possible integration of Ayurveda with the western approach in treating neuromuscular diseases, in order to obtain a better quality of life for our patients, will be investigated in a three-year bilateral cooperation project, financially supported by Italian and Indian governments.

Integrative ONcology – Opportunities, Challenges And The Way Forward Pavithran K, MD, DM Amrita Institute of Medical Sciences, Kochi, Kerala, India

Integrative oncology refers to the use of complementary and integrative therapies in collaboration with conventional oncology care (chemotherapy, radiation, and surgery, targeted therapy and immunotherapy). Population-based studies suggest that at least half of all cancer patients use some type of complementary therapy during the course of their treatment or follow up. They are used to improve wellness, improving quality of life (QOL), and relieving symptoms of disease and side effects of conventional treatments. However, the evidence supporting the use of complementary and integrative therapies in the oncology setting is limited. The goals of integrating Ayurveda in oncology is to find convincing evidence of the efficacy of co - administration of Ayurvedic medicines in reducing the side effects of conventional treatment, amelioration of the

Book of Abstracts 49 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine distressing symptoms of cancer, improvement in the quality of life, and enhancement the effect of conventional treatments and healing of mind body and spirit. There are many cancers where effective treatments are not yet available and there are many areas in supportive care (pain, constipation, fatigue, weight loss) where more need to be achieved. Available data from few small scale studies mention the efficacy of ayurvedic preparations in minimizing side effects of treatment (ginger for vomiting, Brahmarasayana for myeloprotction), as immunomodulators (Amrit, amla), to prevent recurrence (Guggulu), to improve the quality of life (rasayanas) and for chemoprevntion (curcumin). Lack of authentic research and misinformation and false claims in the media are the main challenges. Research in integrative oncology is challenging for many reasons. Major challenges include concerns with fitting integrative oncology into existing models of scientific research and difficulty obtaining funding. Properly planned and conducted studies are the need of the hour. To make it more acceptable to clinicians, future focus should be on conducting research, providing education, and delivering evidence-based clinical care to improve quality of life and clinical outcomes for people affected by cancer.

Ayurvedic Intervention In Oncology In Purview Of Epigenetics Pooja Sabharwal, Assistant Professor, Choudhary Brahmaprakash Ayurveda Charaka Sansthan, New Delhi

Epigenetics (Lifestyle) is a new field of biology that is exploring the effect of the environment on cellular behavior. The "environment" includes one's physical, social, and electromagnetic environment as well as beliefs, perceptions, lifestyle, habits, behaviors, and mind-body practices such as Pranic healing. With the science of epigenetics we can begin to map out genes that keep us in a healthy state and eliminate those bad genes that have been plaguing humans over the course of time. There is real possibility to prevent and cure for certain cancers & other dreadful diseases. Cancer is the second most common cause of death and accounts for nearly 1 of every 4 deaths there. The World Health Organization estimates that, worldwide, there were 14 million new cancer cases and 8.2 million cancer-related deaths in 2015. It is expected that annual worldwide cancer cases will rise from 14 million in 2015 to 22 million by 2030. This is despite the fact that there is a clear link between lifestyle and cancer prevention. An estimated one third of the most common cancers can be prevented through consumption of a primarily plant- based diet, minimizing chronic inflammation, stress-management strategies, maintaining a healthy weight (BMI), and regular physical exercise. Ayurvedic approach – treatments are individualized for each person Complementary roles of body, mind, and spirit in maintaining health are recognized. Treatment may include changes in diet and/or lifestyle, as well as medicinal herbs and panchakarma therapies. Medications are chosen based on their unique characteristics (Rasa, Guna, Virya, Vipaka, and Prabhava) and the Prakriti and Vikriti of the person being treated. Mind, body, and spirit are the pillars of health and together determine whether a person is experiencing health or is susceptible to disease

Integrative Ayurvedic Care In Diabetes Mellitus – Clinical Experiences Prakash Mangalasseri1 Surendran E2 Jayadevan CV3 ManojKumar AK4 1. Associate Professor, 2.Professor, 3. Retd. Professor, Dept. of Kayachikitsa, VPSV Ayurveda College Kottakkal, 4. Dean, Students Affairs, KUHS

Diabetes mellitus (DM) is caused by defect in insulin secretion or action, or both in turn leads to chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism. Globally 382 million people (8.3% adult population) had diabetes in 2013. 80% of people with diabetes live in low- and middle-income countries.

Book of Abstracts 50 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Diabetes was responsible for 11% of the total global adult health expenditure and 5.1 million deaths. Ayurveda consider DM under the broad heading of Prameha and is caused by BahudravaShleshma (Kapha with increased liquidity), Bahu AbaddhaMeda (increased free fatty acids) and Kleda (excretory portion of body fluids). The particularity of multifactorial etiopathogenesis (nidanadoshadooshyavishesha) in Prameha leads to 3 major types as Kapha, Pitta and Vata and 20 subtypes among them. Unique Ayurvedic Prakrity / Vikrity (Innate / modified attributes) based Doshic diagnosis of Prameha ensure diversified and individualized management strategies in diabetic patients at various stages. Even though the conventional medicine insist intensive glycemic control, the ultimate outcome is not much satisfactory in maintaining euglycemia or avoiding late stage diabetic complications. If the total disease process is considered as a continuum, Ayurvedic health philosophy based management strategies may definitely compliment conventional medicine. In certain circumstances Ayurvedic management may be solely sufficient for individualized care. We have many interesting case series studies in various stages of Diabetes managed with Ayurvedic medicines, Panchakarma therapy and therapeutic dietetics supplemented with life style modifications and relaxation programs. Ayurvedic Integrative medicine in diabetic care represents a broader paradigm of medicine than the dominant biomedical model as it is patient centered, problem oriented and holistic in nature.

Ageing, Cellular Senescence, Cancer And The Role Of Rasayana Rajmohan V 1, Shajahan M A 2, Sudhakaran M V 3 1. Department of Rasasastra and Bhaishjya Kalpana, Government Ayurveda College, Thiruvananthapuram, Kerala 2. Department of Dravyagunavijnan, Government Ayurveda College, Thiruvananthapuram, Kerala 3. Academic Staff College, University of Calicut, Kerala

Ageing is a phenomenon unique to human beings, identified as the accumulation of diverse changes of deleterious nature occurring in cells and tissues during the course of times towards the advancement of age, often responsible for the increased risk of diseases and death. Understanding the mechanism of ageing and search for novel remedies against it could be one of the most fascinating and pounding topics of investigation among the researchers across the globe, in years to come. Cancer is a devastating disease and a leading cause of mortality in the present world. Earlier, the widespread belief was that ageing is antagonistic to cancer. But mounting evidences now suggest that cancer is augmented by ageing process and ought to be the outcome of invariable pathology related to ageing. The indications of various Rasayanas cover inflammatory, autoimmune, degenerative, and hyper proliferative conditions and showing the multi-dimensional capacity of rasayanas to fight diseases by keeping anti- ageing as the major objective.

Integrative Medicine: Ground Realities, Challenges And The Journey Into The Future Dr. P. Ram Manohar, MD (Ay), Amrita Centre for Advanced Research in Ayurveda, Amrita University, Kollam, Kerala, India

It is an irony that in India different medical systems are legally recognised without an official policy for integration. Practitioners of different medical systems remain confined in their own silos and nurture misconceptions about each other. Patients are left to intuitively decide which medical system is best for them in a given situation. Health Care in India is a jigsaw puzzle for the common man. Amrita Samyogam is an attempt to address this socio-medical dilemma. To create a platform to nurture the three Cs - Communication, Cooperation and Collaboration that can

Book of Abstracts 51 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine lead to the development of an Evidence Based Formalised system of Integrative Health Care. It is all about how Allopaths can practice better Allopathy and Ayurvedists better Ayurveda and yet communicate, cooperate and collaborate for better patient care.

What Should We Talk About When We Talk About Basic Research In Ayurveda? Prof. Rama Jayasundar, Department of NMR, All India Institute of Medical Sciences, New Delhi, India

The concept of basic research in ayurveda invokes strong intuitive arguments both in favour and against, especially in the ayurvedic fraternity. Yet it is difficult to pin down what this expression refers to, considering ayurveda itself is an applied science. Greater clarity is definitely required on ‘what questions to address, what system to work on, what methodology to adopt and whether experimental or theoretical research is needed’. In this era of integrative medicine (IM), cognisance has also to be taken of the fact that IM is generally understood as integrating other systems into the toolbox of allopathic medicine. In such a scenario, another relevant question is ‘if ayurveda is going to be integrated into allopathy, what would basic research in ayurveda imply?’. This presentation addresses these issues. It also underscores, through some case in point studies, the challenges in bringing together system level information (ayurveda) and technology shaped by reductionism.

An Integrated Approach To Treatment Of Degenerative Neurological And Skeletomuscular Diseases – Our Clinical Experience Dr.Ramesh R Varier, MD, Arya Vaidya Nilayam, Madurai

A number of patients with degenerative Neurological and skeletomuscular diseases seek Ayurvedic treatment. This is the case in our Ayurvedic Hospital and at our clinics as well. In these conditions, we have observed significant improvements through pure Ayurvedic treatment comprising of Oral medication, external applications and therapeutic procedures when needed. In the case of degenerative conditions, which have not reached terminal stages, Ayurvedic treatment is used mainly for the anti-degenerative aspect of the treatment, while co-morbid conditions like Cardiac conditions, advanced stages of Diabetes, Hypertension, Renal conditions etc are managed by Allopathic specialists. Pain, not responding to the Ayurvedic treatment is also managed with Anti-inflammatory analgesics on SOS basis. This is seen to be essential, to keep the patients in good spirit and to ensure compliance to the fundamental treatment. Ayurvedic treatment and Modern Rehabilitation techniques like Physio-therapy, Occupational therapy and Speech therapy are very effective when used in an integrated manner and seem to have significant synergistic effect.

Integrative Oncology: A Discipline Of Modern Science With The Wisdom Of Traditional Healing Dr. Ravi Mehrotra, National Institute of Cancer Prevention and Research (ICMR) , I-7, Sector - 39, Noida – 201301 [email protected]

Cancer forms a major burden of disease worldwide, with India bearing over a tenth of the global load. The conventional treatment of cancer is associated with significant side effects such as fatigue, pain, malaise and

Book of Abstracts 52 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine nausea/vomiting. Despite advanced research in cancer management, clinicians fail to alleviate these symptoms. Worldwide, an estimated 33–47% of individuals diagnosed with malignancy use complementary alternative medicine or integrative therapies during treatment. Most of these are adjunctive approaches towards controlling the symptoms and enhancing quality of life. Furthermore, with patient survival rates increasing, oncologists have become more sensitive to the needs of cancer survivors and have taken an integrative approach towards managing the adverse effects of cancer therapy. This presentation describes non-conventional therapies commonly used today by cancer patients. Additionally, pre-clinical and the clinical trials for various alternative remedies are also discussed. Evidence regarding the efficacy and safety of these therapies is reviewed, and implications for oncologists are proposed.

Integration Of Medical Systems In Neurology Dr Sandeep D. Nair MD(Ay), Research Assistant, Department of Neurology and Complementary Medicine Evangelisches (Lutheran) Hospital, Augusta Foundation, Hattingen, NRW, Germany.

The integration of medical systems is a considerable solution to the challenge of sustaining world’s health care and is gaining popularity throughout the world. The present talk will emphasize on the origin of idea of integrating two medical systems and will guide decision makers to plan for and implement integrated medical systems. This system redefines the health care paradigm and here the emphasis is to decide what is best for the Patient. Neurology and complementary Medicine department of Augusta Foundation in Hattingen Germany is currently treating patients using different fields of integration specially for patients with extra pyramidal movement disorders like Parkinson’s disease, multiple sclerosis, MND etc. This talk will also highlight the working methodology in a Complementary set-up and discuss about the different research projects like Influence of Vasthi and Ayurveda Diet in Gut Microbiomics and Influence of Nasya in Hyposmia of Parkinsons Patients.

Palliative Medicine And Ayurveda Sanjay Pisharodi, Director, Punaryoga Ayurveda Centre, Wayanad

Palliative Medicine, one of the recent specialties in modern medicine, is the active total care of patients with life limiting disease, when it is no longer responsive to curative or life prolonging treatments, aiming to promote comfort, integrating physical, psychological, social and spiritual aspects of care helping patients come to terms with their impending death as fully and constructively as they can. It seeks to avoid the situation where the interventions are “prolonging death” rather than “prolonging life”. Modern medicine is not comfortable in accepting death as an inevitable natural part of life. Seeing death as a failure, the goal is to somehow prevent it rather than accept. Palliative Medicine for the first time seeks to include the spiritual dimension of health care in modern medicine, educate and accept death as a very normal part of life and helps in deciding the transition from cure to care. Predicting the time of death has been one of the most challenging aspects of Palliative medicine which is vital in making crucial decisions. Ayurveda, accepts death only as a transition point in the continuum of the cycle of life, and life as an eternal phenomenon rather than a bunch of chemicals. It classifies disease conditions as curable and incurable at the very outset of a consultation and communicates it to those concerned. It has elaborate descriptions, both gross and subtle that predict impending death (called ariṣṭa lakṣaṇa), when curative interventions should stop and the person be allowed to pass on. Apart from the person, signs of death are also in the environment which includes the messengers, animals, birds and so on. “Somewhere along the progress of modern medicine, life seems to have slipped out between our fingers and we are now left with only a bunch of chemicals, having to trace our way back to find life” said Nobel laureate biologist, Szent Giorgi. “vāsāmsi jīrṇāni yathā vihāya…” Bhagavad

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Gita Chapter 2, verse 22 explains that “Just as a person puts on new garments, giving up old ones, the soul similarly accepts new bodies, giving up the old ones.”

Sleep Medicine: What Ayurveda Can Contribute? Sanjeev Rastogi, State Ayurvedic College and Hospital, Lucknow [email protected]

Sleep is so much important to human being that it comprises almost 1/3 of some ones whole life span. It has a restorative, regenerative and reparative potential and hence any compromise to this eventually affects all these functions. Sleep disturbances are debilitating and are being linked to many diseases either as their cause or as a manifestation. A global steep rise in non communicable diseases is also supposed to be linked with the aberrations in sleep architecture and quality. There are number of approaches to deal with sleep disturbances including pharmacological and non pharmacological approaches. Ayurveda , on the other hand proposes many simple home remedies and sleep hygiene propositions which seem promising, are in folk lore practice and have indirect evidences of their effectiveness. Simple remedies like milk, head and foot massage, shirodhara seems promising in the effective management of variety of sleep disorders and hence require a thorough review for their possible integration with main stream medicine.

Opportunities For Integrating Ayurveda With Nanotechnology Solutions In Healthcare Shantikumar Nair, Dean Research, Amrita University, and Director, Centre for Nanosciences and Molecular Medicine.

Nanotechnology in the last 15 years has made very substantial and beneficial contributions in healthcare. These include the use of nano sized materials, such as, nanoparticles for drug delivery; and macroscopic materials that are nanostructured, such as nonporous or nano/microporous materials, nano textiles and so on, which can serve as efficient drug delivering agents or implants. All of these technologies have evolved as an enabler to existing approaches to improve efficacy or to reduce toxicity, and to provide slow and sustained release kinetics over long periods to avoid frequently repetitive treatments that increase morbidity. The purpose of this new technology is not to supplant, or replace, existing approaches. Ayurvedic care involves time tested robust approaches that generally involve treatments over long periods in chronic illnesses. Hence there is ample scope for integration with Nanotechnology in many instances. The talk will present opportunities for such integration ad the way forward.

Ayurvedic Management Of Chronic Renal Failure- A Promising And Supportive Alternative Prof. Dr. S. N. Gupta, Head, Post graduate Department of Kayachikitsa, J. S. Ayurveda college & P.D. Patel Ayurveda Hospital, Nadiad (Gujarat), India, Head, Academic Advisory Board, European Academy of Ayurveda, Birstein, Germany

Chronic renal failure (CRF) is a growing and challenging health problem with a worldwide prevalence of 8-16%. Though conventional treatments are effective but of a low priority for the common men particularly in India.

Book of Abstracts 54 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

P.D. Patel Ayurveda Hospital, Nadiad tries to offer alternative support through Ayurvedic management. The treatment consists of bastis (a recto-colonic administration of medicines), rasāyanas in general as well as acting on mūtravaha srotas, food based on Ayurvedic dietetics considering involved doṣas and dūṣyas together with management of basic pathology. An observational study is performed to evaluate the long term as well as short term effect of above mentioned treatment. Out of 417 patients of CRF registered during 2015-16, 275 patients were treated with above treatment plan for one month as hospitalised patients. After one month of treatment, mean eGFR raised from 13.3 to 14.4 ml/mt/1.73mt2 ( P< 0.05). Mean score of symptoms such as swelling reduced from 1.80 to 0.33, nausea from 1.75 to 0.24, general weakness from 2.27 to 0.71, loss of appetite from 2.26 to 0.60, breathlessness from 1.59 to 0.326. Mean urine output in 24 hours was improved from 1.03 litre to 1.64 litre. For the evaluation of long term effect 61 patients were observed after six months treated as outpatient, which shows rise in mean eGFR from 13.0 to 17.8 ml/mt/1.73mt2 (P<0.05), indicating shift of patients from grade 5th to grade 4th of severity. Mean score of symptoms in this group such as swelling reduced from 1.09 to 0.20, nausea from 2.00 to 0.20, general weakness from 2.20 to 0.40, loss of appetite from 2.20 to 0.50, breathlessness from 1.60 to 0.20. The ‘P’ value was < 0. 05 to <0.001 in all the symptoms in both the groups. This shows that Ayurvedic management can offer a big support to the patients of CRF.

Connecting Data To Clinical Predictions: Using Computational Neuroscience For Bridging Modern Medicine To Ayurvedic Explorations Shyam Diwakar Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham (Amrita University), Clappana PO, Kollam, Kerala, 690525, India. E: [email protected]

Abstract: In this talk, a novel strategy of data-driven experimentally validated modelling will be used to show how translational neuroscience studies can be accelerated to help extend neuroscience data from labs to clinical predictions. As a case study, we will look at movement disorders and Alzheimer’s Dementia and their molecular and cellular basis in cerebellum circuits. Primary degeneration of the granular layer of the cerebellum is also an autosomal recessive disorder exhibiting clinical features such as delayed motor development, nonprogressive ataxia, delayed language development with dysarthria and mental retardation (Pascual-Castroviejo, 1994). Recent methods developed for mathematically reconstructing LFP signals (Diwakar, 2011; Parasuram, 2016) will discuss the nature of interaction in cerebellar microcircuitry. We model neuronal dysfunction as seen during ataxia (Prestori, 2008; Goldfarb, 2007; Medini, 2012) to quantify its impact on information processing in the cerebellum granular layer. The reconstruction also modeled changes in synaptic plasticity revealing the role of single neurons in neural ensembles. Changes to single cell properties during LTP and LTD were reflected in the LFP wave suggesting functional roles of neural circuitry in information processing. Using similar methods, we will also explore how behaviour, clinical conditions and neural functions could be mapped to data arising from experimental neurosciences and to reconnect modern medicine and Ayurveda practices through data-driven computational neurosciences.

Antibacterial Effect Ayurvedic Herbal Formulation On Methicillin - Resistant Staphylococcus Aureus (Mrsa) In Diabetic Foot Patients Sintija Sauša MD1,3, Somit Kumar, MD (Ayur)1,2, Tatjana Tračevska PhD3, Arnolds Jezupovs MD, PhD3, Ilona Mandrika4, Baiba Zandersone3, Iveta Liduma PhD3, Agnese Zvaigzne3,Daina Kalniņa3, Svjatoslavs Kistkins3, Valdis Pīrāgs MD, PhD1,3, P.R. Krishna Kumar, MD (Ayur)2

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1 Center for Complementary Medicine, University of Latvia, Riga, Latvia, Riga, Latvia 2The Arya Vaidya Chikitsalayam and Research Institute, Coimbatore, India, 3 Faculty of Medicine,University of Latvia, Riga, Latvia, 4 Latvian Biomedical Research and Study Centre, Riga, Latvia

Emerging bacterial resistance in response to antimicrobial therapy is a world-wide problem, stimulating the search for new antimicrobial compounds. The aim of this study was to initiate an effective collaboration between academic research and industrial partner to explore antibacterial and cell proliferation stimulating effects of the traditional Ayurvedic formulation Jathyadi Thailam and its modifications in diabetic foot patients. The extracts of formulation were obtained using the reverse pharmacology method and processed further for microbiological and cellular studies in vitro. The original formula was modified by preparing the lamellar gel phase emulsion and change in active herbal compounds. As the next phase, the preclinical and clinical studies will be carried out on Latvian patients with diabetic ulcers. Acknowledgements/Funding. The study was funded from LU effective collaboration project No ZD2016/20226, Development of a novel herbal product for wound healing using the method of lamellar gel phase emulsion.

Triphala: Understanding Biological Mechanism For Management Of Obesity Jyotibala Banjare, Supriya Bhalerao, Obesity Lab, Interactive Research School for Health Affairs, Pune

Triphala, a well-known Ayurvedic formulation consisting fruits of Terminalia chebula, Terminalia bellerica and Phyllanthus emblica, is used for the treatment of various ailments. The individual ingredients of Triphala have been studied in vitro and in vivo studies for their effect on adipogenesis and lipid metabolism. There are seldom studies on the formulation, Triphala as a whole. We therefore carried out thorough investigations on Triphala to understand biological mechanism for management of obesity. The in vitro study was planned to evaluate the anti-adipogenic potential of aqueous extract of Triphala (TPaq) using 3T3-L1 pre-adipocyte cell model. Cell viability test was done using MTT assay and TPaq showed no toxicity at different concentrations. When pre-adipocytes were treated with a combination of dexamethasone, isobutylmethylxanthine (IBMX or DEX) and insulin, cells start acquiring a rounded phenotype and within 10-12 days begin to accumulate lipid droplets intracellularly. These were measured using Oil O Red stain at 540nm wavelength. The images of differentiating cells were taken under fluorescent microscope. Gene expression was studied by real time PCR technique. TPaq showed reduction in adipogenesis and decreased the lipid accumulation through down regulation of adipogenic genes (PPAR-γ & C/EBP-α at early phase and GLUT4 & FAS at late phase). The in vivo study was carried out to evaluate the effect of TPaq in high fat diet (HFD) induced obesity animal model. After Ethics Committee permission, obesity was induced in male Wistar rats (125-150 gm) using commercial HFD for 24 days. From day 25, treatment of TPaq was given for next 24 days (i.e. till day 48). Weight was measured every week and biochemical parameters were evaluated on day 0, 24 and 48. On day 48, the animals were sacrificed and brains were collected to estimate levels of monoamines. The changes in appearance and histopathology of liver were also studied on day 48. TPaq reduced weight as compared to disease control animals significantly. It was interesting to note that at the lowest dose, the weight in TPaq treated animals was comparable with normal animals in spite of concomitant feeding of HFD. It also reduced the levels of lipids and glucose thus indicating role of TPaq in Insulin resistance. TPaq also improved the levels of monoamines. It is possible that TPaq might be acting through hunger- satiety mechanism. It also reduced the fatty changes in the livers of the animals. A double blind placebo control clinical study was also carried out wherein TPaq was compared with placebo in overweight and obese individuals. The study drugs were administered for a period of 3 month followed by 1 month off-treatment period to assess sustainability of the results. A total of 80 patients were recruited of which 65 patients (33 from TPaq group and 32 from placebo group) completed the study. The parameters

Book of Abstracts 56 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine evaluated were anthropometric profile (weight, Body Mass Index, circumferential measures viz. waist, hip, neck, mid-arm, mid-thigh) along with body composition analysis (Fat%, visceral fat %, muscle mass, resting metabolism, body age). TPaq showed improvement in all the parameters significantly more than placebo. Interestingly, the patients treated with TPaq showed minimal weight gain after stopping the treatment.

Integrated Approach In Trauma Care Suresh Kumar C, Triveni Nursing Home, Vanchiyoor, Trivandrum

Tremendous advances made in the field of medicine in recent years have opened new era in the history of medicine. Modern medicine has attracted most of the people who are anxious about the maintenance of health of society as well as individual. At the same time there are so many challenging problems existing before the modern medical man. This requires special attention to cultivate untrodden fields of medical science scattered in different systems of medicine round the globe, especially in eastern countries like China, Japan, India and Sri Lanka. People of these countries developed their own science of health and they are deriving benefits through their systems. They have their own special features of medicine which are still alien to so called western medicine. Relief to the patient through any effective media ……. that should be the dictum of medicine. Years ago all indigenous systems were considered as some sort of quackery similar to magic or snake charming. But now intellects have started thinking aloud about alternative medicine. They have stopped judging or evaluating these systems through western parameters. The first and fore most is Ayurveda. Now the whole world is keen to hear about the contribution of Ayurveda in the world arena of health Ayurvedic bone setting practice have been in India for centuries. 85% of patients with fractures in rural areas present first to the traditional bonesetters before coming to the hospital and therefore this mode of care delivery cannot be overlooked. A retrospective study was undertaken to clinically evaluate the Fracture patients who attended Triveni Nursing Home from 01.04.2015 to 31.03.2016. Here the author attempts to narrate the 1. Methods adopted in clinical examination, 2. Modalities to reach a provisional diagnosis, 3. Investigation suggested, 4. Final Diagnosis, 5. Management techniques, 6. Medicine advised and the logic behind, 7. Follow ups and, 8. Evaluation of results. The strength of Ayurvedic Orthopaedics and also its merits and demerits through integrative approach will be highlighted.

Implementation Of Integrating Allopathy And Ayurvedic Therapy For Neurological Disorders. Dr.Syam, Neurologist, ESIC Model Hospital, Kollam, Kerala, India. [email protected]

Disorders of the nervous system affects either central, peripheral nervous system or both. Treatment depends on the precise identification of where is the problem, what caused the problem and how the problem was caused, which requires systematic evaluation. Many of the neurological illnesses have been observed to have therapeutic limitations in allopathy as well as ayurveda. Hence integrated diagnosis and treatment options could be offered for the patients benefit if they are willing. Here the treating physician’s should have sound knowledge of the other therapeutic options. At ESIC speciality hospital, Kollam, the neurologist and ayurvedic physician interact for select patients with neurological illnesses (eg. Non-operable spinal conditions, large stroke) and perform integrated evaluation & therapy according to the available literature and have observed mixed results.

Book of Abstracts 57 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine Integrative Medicine In Infectious Diseases And Immunology: Oppurtunities , Challenges And Road Map Dr. Uma Shankar Prasad

Infectious diseases & immunology currently faces its greatest challenge ever with the emergence of Newer infections world wide, rapidly rising Antibiotic resistance and no new antibiotics in pipeline; Rising costs of immune modulators and cost-effectiveness issues in Developing countries are very pertinent too in such a scenario; Ayurveda with its millennia of wisdom & experience, can offer significantly to this scenario. The fundamental principles aimed at altering the immune response or cytokine modulation, rather than focusing on microbe specific therapy is acutely needed to be looked at very seriously in the present scenario. The Principles of Nutritional modulation ( Amapachana , Langhana, Aapatarpana) gives a new insight into the disease mechanism The employment of appropriate elimination ( sodhana ) therapies to reduce / alter the cytokine ratios needs close study in view of the current understanding of infections / sepsis mechanisms .The principles of management of infections from a doshic point of view is extremely valuable in dealing with new & emerging infections. The Alternative explanation for Autoimmunity as proposed by Ayurveda is fascinating & has sound logical basis. The presentation discusses briefly the possibilities , challenges involved & seeks to chart a road map for this integrative venture.

Comparison Of Clinical Trials In Ayurveda And Modern Medicine Valdis Pīrāgs MD, Professor of Medicine & Director of the Clinic of Internal Medicine, Pauls Stradiņš Clinical University Hospital, Director of the Centre of Complementary Medicine, University of Latvia, Raina Bulvāris 19, Riga, LV1586, Latvia. E: [email protected], M: +371 29237760

For evidence-based standardization of classical Ayurvedic interventions and attesting of new Ayurvedic formulations we need new types of trial designs consistent with the basic principles of Ayurveda. Ayurvedic drugs are similar to complex nutraceuticals containing a natural combination of biologically active substances simultaneously influencing multiple regulatory pathways in different organs and tissues. Restoration of the balance of milieu interior is enabled by purification or palliation of dosha imbalances. It is abundantly clear that randomization of all individual subjects with the same WHO-IDC-10 diagnosis to study treatment or placebo is not appropriate for Ayurveda. Instead they should be replaced with a new concept of subgroup randomization of study subjects according to patient's constitution (prakṛti) and imbalance that underlies disease (vikṛti). In other words, designing of Ayurvedic clinical trials should be personalised and dynamic assessment of progression or regression of disease should lead to modification of the treatment periodically.

Dietetics In Diabetes Mellitus Dr.M.R Vasudevan Nampoothiri, Principal, Amrita School Of Ayurveda

Diabetes mellitus (DM) is a chronic disorder, but with sufficient exercise, moderate diet and proper medication can provide longivity of life. Etiological triad of DM consists of faulty food,sedentary life style, and hereditary tendency. Incidence of DM can be avoided even in people with hereditary background, with regular exercise and dietary modifications. Antidiabetic ayurvedic diet can modify the pathogenesis of the disease. Suitable medicated food along with anti diabetic medicines has got synergesic effect. Ayurveda drugs have less hypoglycemic activity but if some Ayurvedic medicines are taken as an add on therapy, it will definitely prevent the complications of DM.

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Triticum vulgare combined with triphala improves efficacy of insulin by increasing its sensitivity and counteracting insulin inhibitors. Fluid mechanism in the body is altered in DM. So, only medicated water is advised. Storing cereals for long time can reduce its glycemic index without altering the taste. A holistic approach of ayurveda and modern medicines will be the answer for this dreadful disease in future.

Evidence Based Integration Of Ayurveda And Modern System Of Medicine Dr M Vijayakumar MD, DM (Cardiology) Clinical professor, Amrita Institute of Medical Sciences, Kochi, Kerala, India

In spite of the advancement made in medical sciences still there are limitation for optimal treatment of many conditions existing our population .Utilization of the great potentials of time tested Ayurveda therapies along with existing allopathic treatment is likely to offer better outcomes in many conditions. Since Ayurveda is one of the oldest and well documented system of therapeutics it offers an easy route to take up the research in revers direction from bedside to laboratory for validation. The opportunities in this integrated approach may not be limited to treatment of specific situation but is definitely going to open up avenues for disease prevention also. This is not so simple and both medical fraternity needs to spend time on many challenges to establish a sound, evidence based integrated approach .Primarily we need to identify the conditions that are likely to benefit followed by sorting out ethical issues, clinical trial to establish the safety and efficacy of combined approach. Once established such a rational approach is likely to improve the patient outcomes at affordable cost

Current Integrative Oncology Practices in Kerala Dr. Vijith Sasidharan, Director, Sree Krishna Ayurveda Chikitsa Kendram, Vaikom, Kerala

In the current Ayurveda practice of almost all branches of medicine, Ayurveda Doctors are trained to make diagnosis of every single case according Ayurveda and also through modern medical parameters. Hence a very small percentage of cancer diagnosis is done by Ayurveda doctors with the help of modern medical tools and experts during their regular practice. This is the first entry of Ayurveda practitioners into integrative oncology and a very small percentage these patients request for Ayurveda treatments before surgery and chemo. Another small percentage of cancer patients come to Ayurveda practitioners soon after the diagnosis due to fear for surgery or as they are not medically fit or having severe reactions to conventional protocol. Majority of the cases coming to Ayurveda are during their remission through conventional treatments but still having some symptoms, to improve the quality of life or for secondary prevention. Another majority are at the advanced stage of cancer on the palliative treatments trying to seek relief from pain and extend their lifespan through Ayurveda. There were cases where Ayurveda could do little for these patients in all these stages of various cancers. But I am presenting some promising cases with the help of modern prognostic evidences where I felt Ayurveda have a significant role in integrative oncology.

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Book of Abstracts 60 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

CONFERENCE ABSTRACTS

Scientific Abstracts Presented at Amrita Samyogam 2017 Amrita Institute of Medical Sciences, Kochi, Kerala on 6 and 7, August, 2017

ORAL PRESENTATIONS

OA01 1. In Vitro Evaluation Of Phytochemicals From Murivenna Oil And Wattakaka Volubilis Leaf On Fibroblast Cells Elakkiya Venugopal, Sujith Subash Eranezhath, Amitava Bhattacharya, Selvakumar Rajendran

Purpose: Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common joint diseases, affecting 0.5% to 1% of the general population worldwide. Murivenna oil is a commercial medicine used in ayurveda for the treatment of acute injuries like sprain, cramps, closed, fractures and bruises. Murivenna has marked results in the treatment of arthritic disorders like pain, swelling, stiffness and other acute as well as chronic ailment present in the joints. Ayurvedic physicians have found Hemajeevanti (Wattakaka volubilis) to be equally effective as Murivenna. Preparation of Murivenna requires eight different medicinal plants whereas Hemajeevanti requires only one plant Wattakaka volubilis. Hence Hemajeevanti is substituted for Murivenna. Methods: The present study investigates the influence of active phytochemical components present in the leaf extract of W. volubilis and murivenna on fibroblast cells. Various solvents were employed to extract the components present and suitable solvent was selected based on the viability analysis on fibroblast cells and scavenging activity. Results: Ethyl acetate was found to be the best solvent for phytochemical extraction. Phytochemical screening was carried out using standard protocols to analyze the compounds present in murivenna and W. volubilis. Conclusion: From the results ethyl acetate extract was found to be effective towards growth and proliferation of fibroblast cells. Hence, the ethyl acetate extract of W. volubilis may used for drug development process for bone related injuries.

OAO2 8. Cytotoxicity And Apoptosis Induction Of Bioactive Fraction Of Amoora Rohituka Bark In Human Colon Cancer, HCT-15 Cell Line Rajesh Singh K, Vinamra Sharma, Anil Singh K, Santosh Singh K

Purpose: The colorectal cancer is one of the most common cancer in human and its incident rate is increasing due to changing life style. The chemoresistance of conventional synthetic drugs are the major obstacle in the treatment of these ailments. Hence, isolation and development of natural chemotherapeutic agents are the need of the time to overcome the problem. Amoora rohituka Linn., a well known medicinal plant, is described in Ayurveda as Rohitak for the treatment of a wide range of clinical entities such as spleenomegaly, leprosy, anaemia, heart diseases, diabetes, cancer, etc. Therefore, the purpose of the present study was to assess of anticancer property of fractionated bioactive component from the bark of Amoora rohituka Linn. against human colon cancer, HCT-15 Cell line.

Book of Abstracts 61 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Methods: The plant materials were collected from the herbal garden, Faculty of Ayurveda, IMS, BHU and authenticated by the expert. The shade dried material was grinded and subjected to hydro-alcoholic crude extraction. Further bioassay guided fractionation was performed to isolate the potent fraction (s). The cytotoxicity of extracts/fractions was evaluated by MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method and the apoptosis induction was studied by Ethidium bromide-Acridine orange double staining, DAPI staining and DNA laddering methods. Results: The ethyl acetate fraction of the plant bark induced cell toxicity in dose dependent manner while fluorescence microscopy using Ethidium bromide-Acridine orange double staining revealed the mode of cell death by apoptosis. The DAPI staining and DNA laddering studies supported the apoptosis mode of cell death by nuclear morphology and laddering of DNA thread. Conclusion: The study suggested that the ethyl acetate fraction of Amoora rohituka bark enormously responsible for cytotoxicity and apoptosis induction in human colon cancer, HCT-15 cell line that may be used for isolation of pure lead molecule in successive studies for treatment of human colon cancer.

OAO3 10. Appraisal Of Prakriti And Its Relation With Dactylography Sandeep Binorkar, Anand Kulkarni

Background: Prakriti is unique concept of Ayurveda, believed as genetically determined, segregating human beings into subgroups on the basis of physical, physiological and psychological characters. The Prakriti of an individual is determined at the time of conception and is influenced by the pre-dominance of Dosha at the time of its formation in mother and remains unchanged throughout the life. Finger prints of palms also develop in the intra uterine life and remain unchanged thereafter. Its study is known as Dactylography or dermatoglyphics. Present study was designed with an intention to establish the relation between the Prakriti and fingerprints of an individual. Methods: After acquiring IEC approval, total 3504 healthy individuals (1752 male & 1752 female each) aged between 18 to 60 years were recruited in the study. Prakriti of each individual was assessed with the help of pre approved proforma. Their Fingerprints were obtained by rolled method. Each type of fingerprint pattern and their subtypes were identified and analysed for Prakriti differences. Ridge density, fingerprint pattern and minutiae structures were also considered for the significance of differences. Results: Mean ridge density in Vatapradhana individuals was 13.79, Pittapradhana individuals 13.39 and Kaphapradhana individuals 12.58. (ANOVA F-Value 986.7, P < 0.0001). Chi-square analysis shows that the results were significant for the occurrence of Loop & Whorls (P < 0.05) and highly significant for Arch and Composite (P < 0.01) in three groups of Prakriti. Conclusion: Dactylography plays significant role in differentiating Prakriti of an individual with predominance of Dosha.

OAO4 12. Shrinkage And Non-Recurrence Of Ethmoidal Nasal Polyp With Ayurvedic Treatment - Case Report Siva Balaji K, Ashwini BN

Rationale for this case report: The current treatment modality for nasal polyposis is surgical intervention but recurrence rate is high. This case report discusses the effective management with Ayurvedic treatment of a case diagnosed as ethmoidal nasal polyp which was posted for FESS. There is reduction in the size of the polyp, patient is

Book of Abstracts 62 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine asymptomatic and recurrence free for one year. Presenting concerns: A 35-year young man on steroidal nasal spray for a year was admitted in a hospital with symptoms of recurrent nasal blockage and loss of smell. The features were suggestive of nasal polyp ethmoidal type has been diagnostic by CT PNS. Interventions: Application of paste of Sweta Gunja (Abrus precatorius) over the polyp was started and surgery was deferred because the patient responded positively. Outcomes: The outcome of this case study reveals that Nasal endoscopy finding the size of the polyp reduced from grade 3 to 1 according to Lund Mackey scoring, patient became asymptomatic and recovered the sense of smell. There was no recurrence of symptoms or polyp for 1 year Main lesson(s) from this case report: Non surgical intervention of polyp demonstrating the reduction the polyp size, symptoms and also recurrence free for 1 year. But long studies are needed to assess the sustained results.

OAO5 13. Kajjali As A Potent Anti-Leukemic And Apoptosis Inducing Ayurvedic Drug In Chronic Myeloid Leukemic Cells; K562 Cell Line Vinamra Sharma, Sahabjada Siddiqui, Rajesh Kumar Singh, Md. Arshad, Anand Kumar Chaudhary

Purpose: In Ayurveda, Kajjali (black sulphide mercury; HgS) is the foremost preparation of Parada (mercury) and it is used as a prime ingredient in different dosage forms, practiced to cure a wide range of clinical entities since thousands of years. Therefore, the main purpose of this study was to evaluate anti-leukemic effect of Kajjali in chronic myeloid leukemic cells, K562 cell line. Methods: Kajjali is prepared by triturating equal proportion of Shuddha Gandhak and Parada (purified sulfur and mercury) for 72 hours manually until the chief desired characteristics were acquired. The effect of test drug on cell line was evaluated by MTT reduction assay. K562 cells were treated with different concentrations of Kajjali and incubated for 24 hours. The Data obtained in three replicates of experiments, which were analyzed statistically using One-way ANOVA followed by Tukey’s test as compared with plain control. Results: The cytotoxicity assay revealed that Kajjali is enormously toxic against K562 cell line, which affected both, cell viability as well as the morphology of the cells. Cell viability data showed that decreased percent cell viability in K562 cells were 77.36%, 55.27%, 41.04%, 22.33%, and 12.87% at 10µg/ml, 20µg/ml, 30µg/ml, 40µg/ml to 50µg/ml concentrations of Kajjali with IC50 at dose 23.70µg/ml, respectively. Morphological study suggests that increasing concentration of Kajjali significantly change cell morphology and induces cell death by apoptosis. Conclusion: The study concluded that the Kajjali may be used as a potent anticancerous Ayurvedic drug in the treatment of chronic myeloid leukemia.

OAO6 27. DNA Methylation Analysis Correlates Environmental Influence On Extreme Vata Constituition Defined In Ayurveda Haritha Chandran, Mallika Kurat Jayavarma, Moinak Banerjee

Background: Prakriti is the innate human constitution analyzed from the unique phenotypic parameters of an individual. The place of birth or desha has its impact on Prakriti based on the predominant dosha (humor) present in the biosphere. The main objective of this preliminary study was to explore the environmental influence on human constitution through DNA methylation analysis. Methods: Prakriti assessment of 60 unrelated healthy individuals from Jangala (Arid land) and Anoopa desha (Wet land) was done, and among them 38 individuals (19 each) were selected as per their willingness for DNA

Book of Abstracts 63 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine methylation analysis with an informed consent. From these individuals peripheral blood sample was collected for methylation analysis by Global DNA methylation kit. Results: The individuals with vata predominant prakriti had significantly higher (p value<0.001) methylation in arid land as compared to the same prakriti in wet land. There was no significant difference between the vata predominant prakriti of arid land and kapha predominant prakriti in the wet land. Conclusion: The study intimate the impact of place of birth on human constituition as the extreme vata prakriti individuals residing in two different desha shows significant difference in DNA methylation and was found to be higher in arid land. Thus within the same phenotype only the methylation status varied significantly. Thus the integration of basic concepts of ayurveda with contemporary science offers a new quest and inquisitiveness in the mind of researchers.

OAO7 69. Management Of Parkinson’s Disease With Multi-Phasic Multi-Modal Ayurvedic Treatment – An Observational Clinical Study Kalapi Patel, Namrata Shah, Mansi Patel, Manish Patel, Gupta SN

Ayurveda (Indian system of traditional medicine) considers Parkinson’s disease as one of the vātavyādhi (group of neurological and musculo-skeletal disorders). It is difficultly manageable disease therefore it requires a complex multimodal approach in management. The patients with confirmed diagnosis of Parkinson’s disease were enrolled and treated in two phases. The first phase of 30days duration as hospitalized treatments consisted of abhyaṅga with medicated oils (whole body massage) and svedana (whole body steam bath) for two days followed by mṛduvirecana (mild purgation) with eraṇḍataila (castor oil). After that, kapikacchu cūrṇa (Mucuna pruriens) 3 gm, aśvagandhā cūrṇa (Withania somnifera) 3 gm and atibalāmūla kvātha (watery extract of Abutilon indicum roots) 40 ml with 20 ml narāyaṇataila (medicated oil useful in neurological disorders) was given orally twice daily. Mātrābasti (procto- colonic administration of medicated oil), śirobasti (retaining medicated oil in a specially designed leather cap on the head) and nasyakarma (nasal administration of medicated oil) was performed with narāyaṇataila every day. Second phase of a six months as an at home treatment consisted of above mentioned oral medicaments and special diet. Patients were assessed before and after the treatment with the help of unified Parkinson’s disease rating scale (UPDRS). 26 patients have completed both the phases. Statistically significant betterment found in tremors, rigidity, bradykinesia and facial expression (P<0.01). Improvement in UPDRS was statistically significant (P<0.05). According to modified Hoehn and Yahr staging, 16 patients were shifted in to stage 1.5 from stage 3 whereas 10 patients were shifted in to stage 1..

OAO8 71. An Uncontrolled Open Labeled Pre And Post Designed Interventional Clinical Study To Evaluate The Effect Of Ayurvedic Treatment On Deceleration Of Disease Progress In Non-Dialysis Stage Iv-V Patients Of Chronic Renal Failure Mansi Manish Patel, Manish Patel V, Kalapi Patel B, Gupta SN

Objective: A fast progress of the disease is observed in the patients of stage IV &V of chronic renal failure (CRF). This study was aimed to evaluate the effect of Ayurvedic treatment on disease progress in the patients of CRF. Methods: Non-dialysis patients of stage IV-V of CRF having the valid laboratory investigation record of past six months were included in the study. The values of renal functions tests of the date 6 month before was considered RFT1 and the same on the date of the beginning of the treatment as RFT0. Gokshuradiguggulu 1gm thrice, varunadikvatha 40ml twice, 5gm combination of rasayana and bhumyamalakichurna twice and niruhabasti with punarnavadikvatha were given daily for 1 month period. Patients were treated in out-door with oral medicaments Book of Abstracts 64 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

(except niruhabasti) for next 5 months period. The renal function tests were performed after completion of total six months (RFT2). The pre-treatment as well as post-treatment progress was evaluated by calculating RFT0 – RFT1 as well as RFT2 – RFT0. Results: Sixty-five patients were registered during 2016. Twelve patients have discontinued the treatment. The mean of RFT0 – RFT1 for eGFR, serum creatinine, blood urea and hemoglobin were -8.63(↓), +1.87(↑), +16.73(↑) and -1.76(↓) respectively. While mean of RFT2 – RFT0 of the same were +5.06(↑), -1.12(↓), -29.44(↓) and +0.51(↑) respectively. Improvement (P<0.05) was also observed in nutritional status and signs and symptoms of the patients. Conclusion: Ayurvedic treatment decelerates the disease progression and also reduces the signs and symptoms in the patients of chronic renal failure.

OAO9 80. Revalidation Of The Concept Of Apara Ojus By The Assessment Of Haematological Parameters In Children With Recurrent Respiratory Tract Infection Resmi BG, Ajitha K, Abhilash M

Purpose: In Ayurveda, there are certain areas in the science which emphasize the need for more exploration. The concept of apara ojus is one such topic. Prevention of a disease occurs only when the defense mechanism of the body is properly maintained, the function of ojus as per the science. Here, an effort was made to check whether any relation exists between the status of aparaojus in an individual and blood parameters related with immunity. Methods: Immune status of apparently normal children and children who are repeatedly infected with respiratory diseases in the age group 3-6yrs were studied. Their status of apara ojus was also analysed and compared with their immune status. Blood samples were collected and were analysed for T.C., D.C., Albumin-globulin ratio, IgG, IgA & IgM specifically. The status of apara ojus was then compared with the obtained haematological values. The correlation technique used was Spearman’s rank correlation in ordinal scales and in case of interval scales Pearson’s correlation was used. Results: Rogibala, saara and apara ojus are having significant positive relation with each other whereas rogabala is having an inverse relation with apara ojus. Among the haematological factors, Total WBC count, ESR, Lymphocyte count, Midpercent value and platelet count were found to have significant relation with ojus. Those with kapha pitta prakruti were found to have improved immune status. Conclusion: The concept of apara ojus, when applied in a broader sense, can be used to assess the overall immune status and response in children. Recurrent respiratory tract infections, when used as a tool for the revalidation of apara ojus, fits well to the clinical scenario.

OA10 85. Role Of An Indigenous Compound With Caloric Diet And Fixed Daily Regimen In Sthaulya In Childhood Obesity Lovelesh Gupta, Srinidhi Kumar K

Introduction: Obesity is defined as a condition of abnormal or excessive fat accumulation in adipose tissue, to the extent that health may be impaired. Sthaulya (Obesity) is one among the major diseases of modern era. Study type: Randomised controlled open labelled interventional trial. Age Group: Individuals of either sex aged between 5-15 years. Methods: 60 Patients of childhood obesity for present study were selected from OPD and IPD of PG Department of Kaumarbhritya, NIA, Jaipur after screening them for the same by following different diagnostic criteria’s. Various Schools in and around Jaipur were also screened for selection of the patients. Selected patients were randomly

Book of Abstracts 65 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine divided in Group A and Group B, 15 patients in each group. Group A were advised indigenous Ayurvedic compound i.e. Lekhaneeya Gana Drugs along with Bilvadi Panchamoola along with dietary and life style modification and group B were advised to follow strict dietary restrictions which fulfil the caloric requirement of body and instruction Chart was provided for diet and day to day physical and mental exercise. Result and Conclusion: Group A administered with trial drug has shown highly significant results in reducing the symptomatology of Sthaulya (childhood obesity) and additional effects in normalising the lipid profile in comparison to Group B. However Group B treated with only caloric diet as per age and dietetic and life style modification has also shown significant results, thus highlighting importance of diet and exercise in effective management of Sthaulya (Childhood obesity).

OA11 116. An Experimental Evaluation Of The Wound Healing Property Of Chincha Cork And Seed Parvathy S, Shrikanth P

As emphasized by our Acharyas that new knowledge is to be added with the existing knowledge by collecting information from all possible sources . Wound is a common and often encountered problem in day to day practise and it has drawn attention of a large number of scientists all over the world. In spite of brilliant advances in surgical field, wound management still remains a subject of speculation. 24 Albino rats were selected for the study were divided into 4 groups.Group I without any drug treatment considered as a normal Control group. Group II thePovidone iodine applied was considered as Standard group .Group III applied with Chincha(TamarindusindicaLinn) cork masiandGroup IV applied with Chincha (TamarindusindicaLinn) seed masiwere considered as Test groups. Duration of the study was 21 days. The treated group showed significant reduction in the period of epithelialization and percentage wound contraction when compared to control and standard. Histopathological study revealed Test drug treated group showed almost normal cytoarchitecture with very good and complete re-epithelialization.The results suggest that Chincha cork and seed Masi is proved very effective in the management of wound.

OA12 126. Clinical Evaluation Of Effect Of Rajanyadi Churna On Morbidity Incidence In Primary Dentitional Age Group I.E. 6-24 Month, Against Micronutrient Therapy Trupti Motghare, Rakesh Kumar Nagar

Teething is the most common cause of recurrent illness during infancy age i.e 6-24 month This condition is very distressful for growing infants and in classics mentioned as responsible for Sarvarogaayatan which affects the growth and nutritional status also. Therefore present study was done to evaluate efficacy of “Rajanyadi Churna” in dentition related problem against allopathic Micronutrient therapy and to minimize the morbidity incidence in primary dentitional age group i.e. 6-24 month, thus promote the growth by maintaining normal development. Design: Randomized control trial Participants: children age (6-24 month) Methods: 60 patients were selected from OPD and IPD of NIA, Jaipur and local Aanganwadied in Jaipur that were satisfied the inclusion and exclusion criteria. They were randomly divided in two groups. In Group A administered Rajanyadi Churna (100mg/kg/day in 2 divided doses) and in group B. Micronutrient Therapy (100 mg/kg/day, once in a day) for two month of duration with follow up at every forth night. . Results: Non-significant improvement in intergroup comparison, extremely significant improvement in most of clinical features. Conclusion: The trial drug “Rajanyadi Churna” is effective, safe and palatable in reducing morbidity incidence of the clinical symptoms during Dantodbhed over micronutrient therapy.

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OA13 145. Impact Of EMDR On Cardio Function Rajesh Jain, Jyoti Shankar Tripathi

Anxiety disorders are the most prevalent psychiatric disorders and one of the most costly Anxiety disorders also increase risk of cardiovascular disease (CVD) three- to fourfold, after accounting for sex, substance use, and depression while risk of cardiac mortality is increased twofold. Here, we examine the impact of the anxiety disorders on a psycho-physiological marker of health and well-being, heart rate variability (HRV). Previous studies are characterized by contradictory reports, highlighting the comprehensive approaches in clinical treatment. cardiovascular disease (CVD) can be controlled through the sattvavajaya (Ay.psychotherapy) Satavavajaya is that method of treatment through which one tries to bring intellect (dhi.) fortitude (dhriti) and memory(smriti) of the patient to the optimum state. Eye movement desensitization and reprocessing technique (EMDR) can be a prototype of satvavajaya chikitsa as it attempts to install positive and wholesome memories (smriti) in to patient and remove (delete) the negative (unwholesome ) thoughts by using sensory modalities like visual (eye movement) and auditory senses. Eye Movement desensitization and reprocessing (EMDR) therapy is an integrative psychotherapy approach that has been extensively researched and proven effective for the treatment of trauma and blocked/negative memories (unwholesome). It is a set of standardized protocols that incorporates elements from different treatment approaches .EMDR therapy also helps to treat many types of psychological stress, related with psychosomatic reactive depression, PTSD, OCD, panic anxiety disorder like IBS ,CAD,CVD, etc. Hypertension with apparent stressor based strictly on the principle of sattvavajaya chikitsa.

OA14 147. A Pre-Test And Post-Test Study To Assess The Effect Of Virechana In Lowering Lipid Profile Anupama Dileep J, Sundara Raman, Siva Balaji K, Ashwini Belludi

Background and Aim: Lipid lowering agents can have side effects like muscle pain and needs long term medication for normalizing the lipid levels. Virechana makes markedly varying reduction in the lipid profile. To determine the effect of virechana in lipid profile. Design: A pre-test and post-test study Setting/Participants: A sample of 11 patients with high lipid profile were selected. 7 out of 11 patients (63.6%) had borderline high total cholesterol(>200 & <240mg/dl) and 4 patients (36.3%) had high total cholesterol(>240mg/dl). Patients were treated with snehapana and virechana. Results: 5 patients (71.4%) out of 7 with borderline high total cholesterol were normalised (<200mg/dl). 3 patients (75%) out of 4 with high total cholesterol was reduced to borderline limits. Paired t-test demonstrated that patients showed clinically and statistically significant result after the virechana and was recorded. Significant results were obtained in various parameters of lipid profile with total cholesterol (p<0.000), HDL (p<0.001), LDL (p<0.001), TGL (p<0.002), VLDL (p<0.052), LDL HDL ratio(p<0.001). Conclusion: Outcome of the study reveals that patient with borderline lipid profile can be normalized with a course of virechana. Those with high range lipid profile require intensive internal medication along with virechana for normalizing.

Book of Abstracts 67 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

OA15 152. Prophylactic Actions Of Medhya Rasayana Drug- Shankhapushpi (Convolvulus Pleuricaulis Chois) On Drosophila (Common Fruit Fly) Model Of Alzheimer's Diseases Wasuki Upadhyaya

Purpose: In Modern medicine, the currently approved drugs for treatment of Alzheimer's disease exhibit modest and transient effects in improving disease manifestation and could hardly prevent, halt, or reverse the disease. Therefore this study tries to evaluate the effect of prophylactic feeding of Shankhapushpi in Drosophila melanogaster (Common fruit fly) model of Alzheimer's disease. Methodology: Hydro alcoholic extract (50:50) was obtained from dried and powdered Shankhapusphpi (Convolvulus pleuricaulis Choisy) plant. Two types of fly models- GMR-Ab 42 K52 GMR-Ab 42 K53 (Alzheimer’s disease) and wild type (healthy) were used. In both the types, the control group was reared on standard food, while the test group was reared on standard food mixed with Shankhapushpi extract 0.5% (grams/100ml) and subjected to apoptosis assay of eye imaginal discs of third instar larva on 5th day and lethality assay, eye morphology examination of adults after 12th day. Results: The diseased test group, in lethality assay had increased number of survivor flies, in examination of eye morphology showed significant reduction in disorganization, On apoptosis assay, showed decreased fluorescence (thus apoptosis) than the control group. Conclusion: In view of the results it maybe concluded that prophylactic feeding of Shankhapushpi results in the reduced manifestation of neurodegeneration in Drosophila melanogaster model of Alzheimer’s disease.

OA16 154. Mahatiktaka Kwatha Vs Kwatha Tablet In Functional Dyspepsia - A Randomized Controlled Trial Jithesh Madhavan, Renuka R Gayal

Background: Functional Dyspepsia(FD) is one of the commonest clinical presentations in a gastroenterology OPD, which is of multifactorial origin and available medicines are having their own limitations. Several Ayurvedic combinations are effective here, with positively reported studies. Mahatiktaka Kwatha is reported as effective in FD and used in clinical practice. Many are reported having gastric irritation on the continuous intake of Kwatha, with added preservatives, for the expected shelf life. Kwatha modified to tablet is tried for efficacy and compared, in FD. Analytical study was done with HPTLC to compare kwatham with tablet prior to clinical trial. Objectives: • To evaluate the role of Mahatiktaka kwatha tablet in FD, • To compare the efficacy of Mahatiktaka kwatha Vs Kwatha tablet in FD Methodology: RCT done with sample size of 100. Subjects within proposed inclusion criteria were recruited in random from gastro OPD, after prior written consent. The diagnostic criterion was ROME III criteria for FD. Kwatha was used in the control group with 10 ml twice daily, diluted with 40 ml warm water. Two Kwatha tablets were used twice daily, 1 hour before food for 30 days and assessment was done with the GSRS Scale. Results: As per GSRS score, the trial drug, the Kwatha tab was superior in efficacy when compared with Kwatha, on overall assessment. There was no significant difference among groups on 1st assessment, 1% significance on 2nd and 0.1% significance after follow-up. The percentage of relief was also slightly better in the trial group.

Book of Abstracts 68 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

OA17 158. Metamorphosis Of A Classical Formulation Into A Value Added New Dosage Form Lekshmi Priya S, Sarath Chandran C, Aneesh MB, Divya P

Kamadugha Rasa mentioned in Rasayogasara has been taken into consideration. The study aims to prepare a Suspension which is a value added formulation of kamadhugha rasa and to compare with its original form. The liquid dosage form may provide better patient compliance for those with swallowing difficulties. There are potential advantages of oral liquid dosage forms, such as no dissolution time and rapid absorption from the stomach/ intestines compared to solid dosage form. Considering these literary facts, liquid dosage form suspension was selected. Thus sticking on to the basic principles by Acharya value addition was done in classical Kamadhugha rasa form. While preparing suspension, instead of water amalaki swarasa was used. Artificial sucrose was replaced by sugar mentioned as adjuvant in the formulation. The suspension was preserved by adding honey, a natural preservative. In addition to honey, Vitamin C in amalaki also serves as a preservative. Based on trial & error initially 6 suspensions were formulated and were evaluated on the basis of following parameters like Physical evaluation, Particle size distribution, pH, Redispersibility and Sedimentation Volume. Out of which the best developed formulation was subjected to further evaluation like Flow rate,Viscosity,Stability Studies.Thus an ideal Ayurvedic Suspension was formulated as per the Remingtons Law Of Pharmaceutics. In present scenario society is in need of an adaptable dosage form.Here plays the magnitude of modern technology adaptation by sticking on to the principles of Ayurveda.

18 161. A Controlled Clinical Study To Evaluate The Efficacy Of Ayurvedic Treatment In Patients With Cerebrovascular Accident Of More Than Two Years Duration Indulekha VC, Radhakrishnan VN and Chandra SR

Introduction:. An around 50% stroke survivors need proper rehabilitation and is a big challenge to existing health care systems; especially after two or more years. Ayurvedic literature highlights the symptoms such as chestanivritti (difficulty in movements) and weakness of one side of the body along with ruja (pain) & vakstambha as Pakshaghata (Hemiplegia). Being a vata disorder, it has been managed with Snehana (unctuous substances) snigdhasweda (sudation), mridushodhana (elimination therapies like purgation) and rasayanas (rejuvenators). Material and Methods: 28 Diagnosed patients of CVA of more than two years duration, of both sex, age -40-70 years included in the study and divided into two groups. The 15 patients in trial group was admitted in college hospital and given internal medicines like kashayam, Gulguluthikthaka grutham and treatment modalities like kayaseka, vasti (medicated enema) etc were done in all patients. The patients on modern medication and some exercises were kept as control group continued out patient consultation in Department of Neurology, Assessment was done with Activities of Daily Living (ADL) score- Barthel index at base level, 3 months and six months. Results and Discussion: Out of 28 patients, 93% had hypertention,32% had speech problems, 57% were independently mobile, 32% were using some walking aid, while one patient was bedridden due to bilateral CVA. Compared to control group, treated group showed good improvement in ADL score (p < 0.05), which might be due to Ayurveda treatment modalities by amplification neuronal and muscular functions.

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OA19 166. Anti-Proliferative Effects Of An Herbal Formulated Cream On Human Keratinocytes And Its Implication For Psoriasis Treatment Baidyanath Mishra, Vivekanand Ramana, Sujata Mishra

Purpose: Psychosocial aspects are the current focus of research on chronic dermatoses. These aspects may contribute to exacerbation of psoriasis in 40 to 80% of cases, thus having great impact on patients’ quality of life. Patients with psoriasis use specific coping strategies to deal with their skin disorder when compared to other patients with chronic skin disorders; they also present stress levels as high as the control group. The integration of results enables understanding the special state of mind experienced by psoriasis patients to deal with the condition, thus showing the urgent need to develop broader intervention strategies, which also involve the social and psychic dimensions. In the present study, we screened the study material for its anti-proliferative properties using cultured human HACAT keratinocyte cell model. Our experimental results suggest that I Psoridex Cream, designed by R & D Team of InnoVision Healthcare, is a promising source which can be effectively used as an herb- based topical agent for psoriasis treatment. Evidence is provided that inhibition of keratinocyte proliferation and improving skin hydration via induction of aquaporin-3 stimulation is the possible underlying mechanism for the observed anti-psoriatic action of study material. This study aims in coping strategies and to identify stress levels of patients with psoriasis. Methods: The test substance adopted is HACAT (Human, Keratinocyte). HaCaT (Human, Keratinocyte) Maintenance: Stock cells of HaCaT were cultured in DMEM supplemented with 10% inactivated Fetal Bovine Serum (FBS), penicillin (100 IU/mL), streptomycin (100 μg/mL) and amphotericin B (5 μg/mL) in an humidified atmosphere of 5% CO2 at 37°C until confluent. The confluent monolayer cultures (HaCaT) was dissociated using TPVG solution (0.2% trypsin, 0.02% EDTA, 0.05% glucose in PBS) and cells were sub-cultured by centrifugation. The stock cultures will be grown in 25cm2 culture flasks. Preparation of culture for experiment: The confluent monolayer cultures were seeded at 1 x 105 cells/ml into the microtitre plate 96 well (Tarsons, India). The cultures were incubated in humidified atmosphere of 5% CO2 at 37°C until confluent. Results: I Psoridex cream showed low cytotoxicity with CTC50 value over 1000 μg/ml. Test substance exhibited moderate anti-proliferative property in a dose dependent manner over control. Anti-proliferative activity of test substances against HACAT cell lines at test concentration of 250 % stands 16.41% of anti-proliferation activity as compared to 9.34 % with dose of 125% of test concentration. Protein conc. of the test substance against HACAT cell line with 250 µg/mL at test dose yields Protein conc. (µg/mL) as 0.780, whereas for 125 µg/mL test does yields protein concentrate 0.8525. Conclusion: Collectively, the results of this study confirm that the study material, I Psoridex Cream, is capable of inhibiting mitotic proliferation rate in cultured HACAT keratinocytes. Given the targeting of keratinocyte as a relevant biological target, the observed anti-proliferative actions might probably provide the underlying mode of action of the test substance and also rendering it as a promising therapeutic herb based candidate for treating psoriasis.

OA20 168. Clinical And Immunological Outcomes In A Case Of Allergic Asthma Through Ayurvedic Management - A Case Report Jyotish Jayandan S, Mahesh Kundagol C, James Chacko

Rationale: Ayurvedic Management on the basis of Tamaka Shwasa Chikitsa is able to bring about Immunomodulation in conditions of Allergic Asthma. This Case Report is the first of its kind in reporting

Book of Abstracts 70 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Immunomodulatory changes along with clinical changes in conditions of Allergic Asthma. Presenting Concerns: A 27 year old lady approached Amrita Ayurveda Hospital with presenting complaints like Shortness of breath, wheezing since 2 months, expectoration of sputum since 5 months, occasional cough and was diagnosed as Allergic Asthma according to GINA criteria and was adviced IPD intervention. Interventions: She was managed with Amapachana with Trikatu Choorna followed by Snehapana with Shatpala Ghrita till attainment of Samyak Snigdha Lakshanas for 6 days. She was given three days of Sarvanga Abhyanga with Lavanayuktha Tila taila followed by Bhashpa Sweda and Virechana with Abhayadi modaka on the third day. She had Avara Shudhi with 6 Vegas. After her Samsarjana Krama she was given Chitrakahareetaki Lehya as Rasayana (Immunomodulator) for a period of one month and was further evaluated. Outcomes: Her post treatment results showed much changes in her symptoms and investigations like Serum IgE levels near normalised from 848 to 500, PEFR changed from 200 to 350 and Asthma Control Test changed from 20 to 24. Main lessons: Cost- effective and short span of Ayurvedic management can stabilize the Hypersensitivity condition in Allergic Asthma. Treatment has also brought about Immunological stability in the condition. Hence we understand that Allergic Asthma can be managed at both Clinical and Immunological levels through Ayurvedic management.

OA21 173. Effectiveness Of Ayurvedic Treatment In Acute Renal Failure In Bites Of Vipera Russeli - Study Proposal For A Randomised Controlled Trial Preethi Mohan, Abhaya Kumar Mishra

Background: Acute renal failure (ARF) is the most common complication in bite of Vipera russeli. Simple low cost ayurvedic remedies can be a good alternative in ARF instead of directly going to peritoneal dialysis as in conventional methods. The aim of this study is to evaluate the effectiveness of ayurvedic treatment in treating ARF in patients with viper bites. Methods and Design: In a randomised controlled trial, 50 patients presenting with stage-1 ARF from viper bites based on KDIGO criteria (Kidney Disease-Improving Global Outcomes). ie; serum creatinine 1.5-1.9 times baseline or ≥0.3 mg\dl increase or urine output≤ 0.5ml\kg for 6-12 hrs) will be randomised into two groups. Conventional group receives anti venom, antibiotics and diuretics as indicated. Second group receives Ayurvedic treatment protocol including decoction, lepa for local application below the navel, dhaara and phalavarthi prayoga. Both groups will receive treatment for one week. Assessment is based on the change in KDIGO scoring after 1 week. Statistical comparison is based on unpaired ‘t’. Discussion: Major hurdle for the study are the ethical issues and lack of compelling preliminary data warranting clinical trials. So before directly going to the study, an experimental study on glycol induced rat can be done. In three different case reports, significant improvement was observed in the KDIGO criteria after Ayurvedic medication. Several anecdotal reports are also available. So a pilot study with greater number of cases can resolve the ethical issues. A combination of the two streams of medicine can be used for better outcomes, to reduce the economical burden and also to increase the survival rate in ARF due to snake bite.

OA22 176. Management Of Ascites Through Ayurveda- A Case Study Sreelekshmi GU, James Chacko, Krishnakumar K

Rationale: The abnormal fluid accumulation in the peritoneal cavity is called Ascites, known as Udaram in

Book of Abstracts 71 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Ayurveda. Hyperdynamic circulatory dysfunction is supposed to occur in ascites, which can be corrected by the application of Ayurvedic line of management of Udaram(Nithya virechanam), by modifying the fluid dynamics of the cells and the lumen, thereby improving the QOL of the patient. Case Presentation: A 62years old male who was a chronic alcoholic since 6 years, presented the complaints of dyspeptic symptoms, gradual onset of abdominal distension, and swelling of both legs,1 year back. Since abdominal distension and pedal oedema progressed further and developed florid features of ascites,after Gasteroenterology consultation,he underwent tapping.He also developed generalized oedema and features of encephalopathy for which intensive care was sought for. Since then he underwent tapping on various occasions. Examination revealed clinical features of ascitis,pallor,Jaundice,Visible veins on Abdominal wall,Increased JVP,Huge pitting oedema of legs and the Child Pugh score was 12. Abdominal girth at umbilicus- 104 cm and weight-63 kg. The patient was diagnosed with Grade 3 ascites. Management and Outcome: Hingutriguna thailam with lukewarm milk was given on empty stomach for 36 days. Aviltholadi bhasma kanji,and hitaharas are used for diet.Lepam and thalam externally and shamanoushadhis internally. The patient got discharged after 36 days,when the abdominal girth,weight and pedal oedema are reduced and the child pugh score become 8. Discussion: This case demonstrates a classical presentation of ascites which was responded well to the line of treatment mentioned in Ayurveda,by giving positive variations in clinical and biochemical findings.

OA23 177. Effect Of A Multimodality Ayurvedic Treatment In A Case Of Vesiculobullous Disease Aiswarya IV,Parameswaran Namboothiri K and Anandaraman PV

Rationale: A vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae. The scope of Ayurvedic approach to address such diseases is discussed in this paper. The case reported here showed significant regression in the condition within two weeks of Ayurvedic treatment with no signs of relapse. Case Presentation: A 32 year old female, presented with complaints of blisters over both upper and lower extremities associated with oedema, burning sensation, pain, severe itching and oozing since three months. Management and Outcome: She was given internal medication after ascertaining the Dosha(humours) involved. The involved Dosha were Kapha(binding factor) and Pitta(metabolic factor). External therapies included herbal paste application and washing with herbal decoction. There was arrest in the progression of blister and oedema during the first week followed by erosion and healing of blisters within 14 days of OP level management. Photographs were taken during and after the treatment for records. The affected area of skin started to peel off following rupture of bullae and was replaced by normal skin without any scarring or hyper pigmentation but secondary milia formation was noticed. There was marked relief in pain and burning sensation. Itching had reduced comparatively but still persists for which she is under the follow up. Conclusion: PittaKaphahara line of treatment was adopted. The internal and external medications thus selected helped in arresting the progression of the condition and complete healing of blisters. There was reduction in all other associated signs and symptoms with no signs of relapse.

OA24 178. Ayurvedic Management Which Reduced Dose Of L-Dopa And Progression Of Symptoms In Parkinson’s Disease - A Case Report Binth Salim Rakhi, Prathibha CK, Parameswaran Namboothiri K

Rationale: Parkinsons Disease is a neurodegenerative condition of motor nervous system which is similar to

Book of Abstracts 72 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Kampavata referred by ayurvedic classics. The principle of treatment in Ayurveda is Vatanulomana(reducing morbid vata dosha), srotoshodhana (clearing the channels) and brimhana (nourishing therapy). The patient got marked improvement without any further progression. Presenting Concerns: A 58 year old male diagnosed as parkinsonism 15 yrs ago had the complaints of reduced arm swing, tremor of both hands, restricted movement of the limbs, postural instability, festinant gait, loss of taste and smell perception. He was on L-DOPA 700mg/day. Interventions: The Ayurvedic protocol includes Dashamoola Kashaya Dhara (pouring lukewarm decoction of medicated drugs over the whole body) for 7 days, Sarvanga Abhyanga (Whole body massage) for 7 days along with Shirodhara (pouring medicated liquid over the head) as inpatient. This protocol was repeated every year with internal administration of Mahabhutarnava ghrita, with balaguduchyadi and balasaireyakaadi kashaya. .The internal medications were continued throughout. Outcomes: Improvement were observed in tremor, co-ordination, balance, walking capacity, sensations of smell and taste. Accordingly L-DOPA dose was reduced from 700mg to 100mg/day. Assessment with PDQ-39 scale shows reduction in the score from162 to 144. Schwab and England Activities of daily living scale shows improvement from 30% to 50%. Main lesson(s) from this case report: An integrated approach will be effective in managing Parkinson’s disease. Ayurvedic medications can arrest the progress and so can regress the dose of L dopa. Since it is a chronic condition it requires long term treatment.

OA25 180. Management Of Bhagandra (Fistula-In-Ano) With Integrative Surgery (Allopathy And Ayurveda) - A Case Report Santosh Sathyarthi, Prasanna Rao

Purpose: Sustenance of human life depends upon the healthy journey of food from mouth to anus. Any disturbances in this can cause a great discomfort. One such discomfort is Fistula-in-ano at the anus. However, the modern surgical care, as a stand alone line of management does not always prevent its recurrence. Therefore, an approach integrating the principles of Allopathic and Ayurvedic care tried in a known case of recurrent fistula-in-ano, to prevent from further recurrence. Methodology: 25 years old female, known case of recurrent fistula presented hospital, with complaints of recurrence of symptoms (pain and pus discharge from perianal area) since 15 days. Past history revealed that she had undergone surgical intervention thrice for fistula and once for perianal abscess in previous year. TRUS and fistulogram reports suggested of Trans-sphincteric perianal fistula. Hence an integrated approach of Fistulectomy was conducted along the arm of fistula using Kshara sutra (Alkaline thread) ligation followed by ksharkarma (application of alkaline paste) and kshara varti (insertion of alkaline wick) along with a course of multiple antibiotics, analgesics, antacids in injectable forms. Yastimadhu taila was used in the form of gudavarti (anal pack using wick) and abhyaarista. Also Matra basti (one of the enema protocols) is administered twice daily. Result: Signs of adequate healing seen. Patient also report relief in the symptoms. The Patient need to be followed up next two months for integrative long term effect/relief. Conclusion: Therefore an integrated surgical care for recurrent fistula-in-ano is viable option to be explored through clinical trial.

Book of Abstracts 73 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

OA26 183. Reduction In Score On Oswestry Disability Index In Lumbar Spondylosis After An Ayurvedic Intervention - A Case Study Malu. Vimal S, James Chacko, Devipriya Soman

(1)Rationale of this case report: The present day management of Lumbar Spondylosis involve the usage of NSAIDS, corticosteroids, Analgesics etc which on continuous use leads to complications like gastritis, kidney failure, liver disorders etc. Clinically the symptoms of Katigraha explained in Ayurvedic classics is similar to the condition of Lumbar spondylosis, hence the same treatments may be adopted for Lumbar Spondylosis. This case report discusses the successful management with Ayurvedic treatment of a case diagnosed as lumbar spondylosis. (2)Presenting concerns: The present case is about a 36 year old male diagnosed with Lumbar spondylosis as per ICD 10 M47.016 criteria having the clinical picture of progressive spinal stiffness, episodic mechanical back pain with an Oswestry Disability Index of 28. MRI revealed degenerative changes and diffuse disc bulge at L4/L5 and L5/ S1 levels. The patient was dependent on pain killers when admitted. (3)Interventions: The treatment protocol included Katibasti with Sahacharadi taila (7 days) followed by Erandamuladi Madhutailika basti (7 days) along with Sahacharadi kashaya internally (50 ml BD B/F). (4)Outcomes: At the end of 14th day, the re-assessment was done using ODI and the score reduced to 16. Hence Kati basti followed by Erandamuladi madhutailika Basti and sahacharadi kashayam is effective in improving ODI within a span of 14 days. (5)Main lesson(s) from this case report: The ODI reduced from severe to moderate disability within a short time period. The patient had significant relief without using painkillers. Further studies are needed to see whether Ayurveda has better outcomes in long term.

OA27 193. Nebulization In Ayurveda -A Novel Way Of Drug Delivery In Bronchial Asthma Renju Rajan, Delvin Robin T and Vandanarani M

Opportunities:Nebulized drugs in bronchial asthma has been applied as a non-invasive route with reduced serious adverse reactions and is equivalent to or more efficacious than its intravenous counterparts. From various clinical trials it was found that prolonged use of corticosteroids and beta 2-bronchodilators have some adverse effects. So there is a scope in Ayurveda for developing a nebulizer. Challenges:Dhoomapana (inhalation of medicinal fumes) is the nearest comparison for nebulization in Ayurveda. But inhalation of fumes is difficult to perform. If we convert the dhoomapana technique to aerosol it will be more acceptable by patients. Studies on various drugs used in dhoomapana is found to have volatile contents and have anti asthmatic/anti allergic /anti histaminic/bronchodilator action. Way forward:A technique to convert dhoomapana drugs to nebulization fluid was found in a study by Kajaria et al. i.e. through the classical method of preparation of decoction/ through Soxhlet process by hot percolation method or extraction of volatile oil through steam distillation. Another methods observed are- preparation nebulization of biodegradable Nano particles; powdered root of R. communis was extracted successively with 95% ethanol using Soxhlet extractor is found to have anti-asthmatic activity. Gupta et al. established anti-asthmatic potential of alcohol extract of Sala. All these evidences shows that dhoomapana drugs can be converted to aerosol form for the management of Bronchial asthma. This approach helps to opens the area of integration between Ayurveda formulation and modern technique.

Book of Abstracts 74 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

OA28 194. Reporting The Clinical Outcome Of Bahiparimarjana Chikitsa In Combination With Active Resisted Exercise In Osteoarthritis Knee- A Case Series Study Athira MP, Ananthram Sharma, Prathibha CK

Purpose: The prevalence of Osteoarthritis(OA) Knee increases with age and is one of the most common cause of physical disability. Many Ayurvedic treatment principles are proved successful in managing OA Knee. It is also managed by surgery, allopathic medications and even by Physiotherapy. This study is aimed to find out the combined effect of Bahiparimarjana Chikitsa (specific Ayurvedic external therapies) and exercise therapy in reducing the symptoms of OA among the patients of knee osteoarthritis. Outcome Measures: VAS, ROM, WOMAC Scale, Foot pressure, subjective symptoms. Design: Pre and post test study Materials and Methods: 22 diagnosed cases of OA Knee were selected from OPD of Amrita Ayurveda Hospital between the age group of 45-70 years. They were administered Bahya Snehana and Swedana along with active resisted exercises for 14 days. Result: Thus obtained data were analyzed statistically with wilcoxon signed rank test.The statistical values in VASscale(P<0.001), ROM(Rt-P<0.004,Lt-P<0.001, FP(Lt-P<0.042,Rt-P<0.038), WOMACscore(P<0.004). There was improvement in almost all the subjective parameters. Discussion and Conclusion: The Bahiparimarjana Chikitsa acts on the pain gate to reduce the pain and tenderness. The oil application and the heat improve the circulation which helps in removing the waste products and nourishing the synovium. The elasticity of the surrounding structures was thus increased which significantly improved ROM. This Ayurvedic therapy when supported by the exercise had significant improvement in all aspects of OA Knee. So a combined therapeutic protocol can be adopted in the management of OA Knee.

OA29 195. An Ayurvedic Management Of Adhesive Capsulitis -A Case Report Sandu Pillai, James Chacko, Krishnakumar K

Rationale of this case report: On analysing the signs and symptoms of Adhesive capsulitis, it can be incorporated under broad heading “Apabahuka”. Nasya and Uttarabhaktika snehapana forms the main treatment principle in the management of Apabahuka. There are many research works done on Ayurvedic management of Apabahuka either by Nasya or by Uttarabhaktika snehapana, but no works were done on assessing the combined efficacy of the two treatment modalities. This case report discusses about an effective and economical treatment in the management of Adhesive capsulitis. Presenting complaints of the patient: A 59 year old lady was admitted at Amrita ayurveda hospital for 7 days with right shoulder pain and restricted ROM of right arm which is clinically suggestive of Adhesive capsulitis. Intervention – Patient was given first 4 days of Pachana-Dipana with Trikatu choornam. Next 7 days of Nasya treatment followed by 7 days of Uttarabhaktika snehapanam. Outcomes: The outcome of this management was appreciable, as it resulted in positive changes in DASH Score from 55 to 39 with higher points indicating higher disability. Also marked improvement were noted in Simple shoulder test (Questionnaire) and Shoulder ROM. Main lesson from this case report: Although Adhesive capsulitis is a self-limiting disorder that resolves in 1-3 years, this case report suggests that symptomatic relief can be achieved by this ayurvedic management assessed on the basis of modern parameters.

Book of Abstracts 75 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

OA30 197. Uttarabasti (Intravesical Drug Delivery) – An Effective Therapy For Chronic Urinary Tract Infection Bismi HB , Anandaraman PV and Prathibha CK

Urinary Tract Infection (UTI) is the most common bacterial infection managed in general medical practice. Chronic urinary tract infections (UTIs) are infections of urinary tract that either does not respond to treatment or keep recurring. Women are more prone to UTIs because they have shorter urethra, which allow the bacteria quick access to the bladder. Urinary Tract Infection includes Cystitis, Urethritis. In Ayurveda, the symptoms of UTI can be correlated with Mutrakricchra. UttaraBasti is a specific treatment procedure mentioned for the bladder disorders. Mutramargagata UttaraBasti is the administration of medicines through the urethral route. A study was conducted in 30 female patients having UTI, to evaluate the effect of UttaraBasti in UTI. UttaraBasti was done with the Kṣīrapāka (milk decoction) prepared with Gokṣura (Tribulus terestrius), Eraṇda (Ricinus communis), and Śatāvari (Asparagus racemoses) which are having anti inflammatory, analgesic activity. The procedure was done for five consecutive days. The assessments were done before the treatment, after the treatment (after 5 days) and during follow up (after 1 week) with the symptoms of UTI and urine microscopy. The statistical analysis of the assessment showed remarkable relief of the symptoms in the subjective and objective criteria of UTI and it was continued during the follow up period also. Intravesical administration of Ayurvedic medicines by utilizing the modern techniques for doing the UttaraBasti offers the possibility of obtaining a high concentration of drug. It is a simple and cost effective procedure and found to be a better treatment method for UTI.

OA31 199. Management Of Autism With Ayurveda - A Case Series Gayathri Nair S, Roshni Anirudhan, Mini Muralidhar, Sohini S, Lekshmi MK

Childhood Autism is a disorder of neural development characterized by impaired social interaction and communication, and by restricted and repetitive behaviour. As per WHO, 1 in 160 children has autism spectrum disorder. No data are available from India to provide an India specific estimate of prevalence. Multitudes of people with autism have not been diagnosed in India and more critically do not receive the services they need. Main goals when treating children with autism are to lessen associated deficits, family distress, to increase the quality of life and functional independence. Although exact Ayurvedic correlation is not available, autism may be included under Unmada roga. This work is to share the observations of Ayurvedic intervention along with speech therapy and psychotherapy in childhood autism. Children of both sexes’ aged 3-12 satisfying DSM 5 criteria for autism from IP Department of Government Ayurveda College, Thiruvananthapuram undergoing Ayurvedic treatment modalities along with speech therapy and psychotherapy were observed for 2 months. The study subjects were assessed before and after the study with Childhood Autism Rating Scale and Autism Treatment Evaluation Chart. Data were analysed using appropriate statistical tests. Highly significant improvements were noted in domains like, activity level, relating to people, emotional response, adaptation to change, listening response and in total score. Hence holistic approach of Ayurveda along with supportive therapies was found to be highly beneficial in the management of Autism.

Book of Abstracts 76 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

OA32 200. Role Of Ayurvedic Management In Glanzmann Thromboasthenia - A Case Report Beena Rose PK, Anita Patel, Asha KV

Glanzmann Thromboasthenia is a type of platelet dysfunction due to genetic causes. Symptoms of Glanzmann Thromboasthenia vary from one individual to the next, from mild to potentially life threatening bleeding .This condition is more common in consanguineous marriages. In present study a13 year old girl was brought to the OPD with complaints of bleeding from gums, menorrhagia, prolonged bleeding from wounds, & recurrent respiratory tract infections. She was the first child of consanguineous parents. She had prolonged bleeding from umbilical cord at birth itself. And referred to the modern specialty hospital for further investigations & management& her condition was diagnosed Glanzmann Thromboasthenia .There were recurrent episodes of bleeding from gums ,bleeding spots over the limbs ,recurrent respiratory tract infections and managed with allopathic medicines. In August 2015 she attained menarche and there was heavy bleeding started and all these days she was given blood transfusion. She was brought to OPD when the third menstrual cycle started. The case was considered as rekthapitha & sthambhana treatment was started. The medicines was continued & bleeding was noted to the normal in next cycle. And after that balavardhana & ojovardhana combinations were continued for two months .This is type of platelet dysfunction due to genetic causes so it is considered as a sahaja roga. Since it presented as a bleeding disorder it was considered as rekthapitha . Now general condition was improved & gets symptomatic relief

OA33 209. Ayurvedic Approach In The Management Of Graves Disease-A Case Study Lakshmy Senan C, Balaji Subrahmonyan, Shaithya Raj , Rabinarayan Tripathy

Problem or issue addressed: Graves disease is an autoimmune disease that stimulates follicular cell to increase the production thyroid hormone. Surgery, Radioactive iodine, and lifelong thyroxin supplementation are the only major line of treatment available. This case report discusses the successful management of exophthalmic goiter with Ayurvedic medicines. The patient is healthy and asymptomatic for two and a half years after. Goals : 1) a safe and effective herbal alternative 2) a cost effective and 3) comparatively short duration medication Rationale: The Ayurvedic internal medicines having cutting and scraping effect can effectively reduce the increased thyroid also scrape off the deposits behind the eyeball. Interventions: A 51 Yr/F with the complaint of exophthalmoses, hand tremors; increased heart beat, weight loss, and heat intolerance for 1 year. Palpable thyroid glands enlarged symmetrically. The bulge eye was 24mm.The palpebral aperture was 14 mm vertically and 30 mm horizontally. TFT done, T4 -14.1 ug/dl. She was given Ayurvedic medications guggulu tikthakam kashayam + varanadi kashayam – 1 ounce bid and kanchanaraguggulu tab1bid, on OP basis. Outcome measures: TFT was repeated.The graves ophthalmopathy was analyzed with EUGOGO Criteria Result :Both the palpabral aperture and exophthalmous reduced by 1mm in 30 days and by 4 mm in 4 months . Main lessons from the case report: Ayurvedic drugs could 1) reduce the exophthalmoses 2) normalize TFT 3) symptomatic relief 4) safe, effective and cost effective5) lifelong medication not required.

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OA34 211. Evaluation Of Ayurvedic Treatment Along With Conventional Modern Anti-Hyperglycemic Drug In The Management Of Diabetic Sensory Peripheral Polyneuropathy - An Investigator Blinded Randomized Controlled Trial Manish Patel, Daniel Scheidbach, Bhumika Patel, Mansi Patel, Kalapi Patel, Gupta SN

Objective: Therapy of diabetic sensory polyneuropathy has not been satisfactorily addressed in modern medicine till today. A traditional Ayurvedic treatment has been observed to show satisfactory benefit but has not been compared versus placebo treatment. Hence, a randomized, investigator blinded, placebo-controlled trial was conducted to evaluate the efficacy of Ayurvedic treatment. Methods: Patients of diabetic sensory peripheral polyneuropathy were randomized to Ayurvedic treatment (decoction made from 10gm of sida cordifolia root and 3 gm powder of phyllanthus nirruri twice in a day) or placebo for 3 weeks period. All the patients were instructed to take the conventional anti-hypertensive drugs as per their routine scheduled. A neuropathy analyzer device was used for detection of vibration and thermal sensation threshold while symptoms were assessed using Neuropathy total symptom score 6 (NTSS-6). Results: 30 patients of each group completed the treatment course. Patients receiving Ayurvedic treatment were significantly got symptomatic response at week 3 according to NTSS-6 (P < 0.001 in all the symptoms for Ayurvedic treatment vs. placebo). Vibration, hot and cold sensation of right foot were improved by 19.4%, 2.8% and 11.2% and of left foot by 20%, 4.9% and 17.6% respectively as they came in lower range of moderate affection from severe in Ayurvedic treatment group while they were remain unchanged in placebo group. Conclusion: Patients of diabetic sensory peripheral polyneuropathy treated with Ayurvedic medicine were more likely to achieve clinical response than those receiving placebo. Long term use of Ayurvedic treatment may be more beneficial in these cases.

OA35 215. Evaluation of Hepatoprotective And Nephroprotective Potential Of Bilvadi Gutika In Cypermethrin Induced Toxicity In Wistar Albino Rats Neeraj AK, Prasad UN, Swapna Swayamprabha

Introduction: Bilwadi Gutika is explained as one of the formulations in the context of Ayurvedic snake bite management. It is clinically used in various conditions such as Bhujanga Visha (snake bite), Luta Visha (spider poison), Unduru Visha (rat bite), Vrischika Visha (scorpion sting), Visuchika (Cholera), Ajirna (indigestion), Gara Visha (artificial poison), and Jwara (fever). This Gutika have shown hepatoprotective and nephroprotective activity, and a study was conducted to evaluate the hepatoprotective and nephroprotective effect of Bilwadi Gutika in cypermethrin induced hepatotoxicity in Wistar rats. Aim: To evaluate the hepatoprotective and nephroprotective potential of Bilwadi Gutika in cypermethrin induced toxicity in wistar albino rats. Materials and Methods: The sub acute toxicity was induced and effect of Bilwadi Gutika was evaluated according to OECD guidelines 407, in wistar albino rats. Results: Significant reversal of the toxicant induced changes in the food intake and conversion related parameters were observed at both the dose level. In antioxidant study, significant effect of test drug was seen on lipid peroxidation and antioxidant parameters. At lower dose level degenerative changes in kidney and liver were found to be not reversed but higher dose produced moderate reversal. Conclusion: The results of this study revealed that even though significant reversal of the toxicant induced changes were observed in antioxidant parameters, the food intake and conversion related parameters. The

Book of Abstracts 78 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine beneficial effects of Bilwadi Gutika can be used for therapeutic purpose for the treatment of toxicity due to Cypermethrin along with another cytoprotectant.

OA36 216. An Experimental Study To Assess The Anti-Osteoporotic Effect Of Panchatikta Ghrita (PG) In An Ovariectomized Rat Model Of Osteoporosis Renuka Munshi, Samidha Joshi, Dipti Kumbhar

Purpose: The Study was conducted to evaluate the anti-osteoporotic effect of Panchatikta ghrita (PG) in an ovariectomized rat model of Osteoporosis Method: Institutional Animal Ethics Committee approval was obtained prior to study initiation. 96 female Sprague Dawley rats (260 gms weight) were divided into 8 study groups viz. Sham control group (NC), Disease control (DC), Vehicle control (VC), 3 test drug [Panchatikta Ghrita (PG)] groups (TC1, TC2 & TC3 - 0.9, 1.8 and 2.7gm/kg body weight respectively], Standard control 1 (SC1) received 17α-ethinyl estradiol 1µg/kg/day and (SC2) received Alendronate (7mg/kg/week). All the rats received the drugs daily for 4 months. Bone specific biomarkers viz. Osteocalcin and Trap-5b were estimated at baseline and end of study. Animals were sacrificed on day 121 and their femurs and tibiae harvested for Histomorphometric analysis and bone mineral density (BMD) studies. Research: Increase in Osteocalcin & Trap-5b levels was observed in DC group as compared to NC. All 3 doses of Panchtikta ghrita (PG) decreased Osteocalcin & Trap-5b levels with maximum effect seen with the highest dose of PG which was similar to the standard drugs All the 3 doses of PG increased BMD however the maximal effect was seen at 1.8 gm/kg/wt dose. A significant decrease in a number of osteoclasts, whereas an increase in bone hardness and elasticity was observed as compared to diseased group demonstrating anti-osteoporotic effect of PG. Conclusion: PG increased bone specific markers, BMD and decreased osteoclast formation, indicating its anti- osteoporotic potential.

OA37 218. Evaluation Of Protective Role Of Bilwadi Gutika In Lead Induced Toxicopathological Condition In Wistar Albino Rats Shubha PU, Sudheendra Honwad V and Shrinidhi R

Introduction: Lead is one of the leading cause for toxicity since ancient roman time. Lead toxicity can be compared with the concept of Garavisha. Bilwadi Gutika is a formulation mentioned in Ashtanga Hrudaya under the context of sarpa visha chikita which is widely used by the keraliya visha vaidya in Vishaja conditions like Vruschika Visha, Undura Visha, Gara visha etc. Materials and Methods: Literature on lead, concept of Gara Visha, & Bilwadi Gutika were collected from classical books, modern books & websites. Bilwadi Gutika (Test Drug) was procured from kottakal, Kannur branch and test drug was administered orally for 28 days. The repeated dose toxicity was carried out at 2 different dose levels – TED & TED x 2. Parameters like biochemical, antioxidant activity & histopathological tests are compared with control group for toxicity reports. Results: All the parameters like biochemical, anti-oxidant activity & histopathological findings showed moderate toxicity by lead acetate.In Bilwadi Gutika TED group results were not much evident, but in Bilwadi Gutika TED×2 group significant reversal of toxicity was observed. Conclusion: Analysis of the data obtained during the study indicates the lead acetate at the dose level used induced moderate severity toxic effects. Majority of them were reversed by the Bilwadi Gutika providing evidence for its utility as a universal anti-dote. It can be gainfully clubbed with other mode of therapies or other formulations

Book of Abstracts 79 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine for effective treatment of lead toxicity.

OA38 225. Assessment Of Trailokyasundar Rasa- A Herbo Mineral Formulation For Its Efficacy Against Chronic Myeloid Leukemia In An In Vivo Model Paras Golecha, Siddhisha Kurve, Sheela Pargunde

Purpose: Trailokyasundar rasa is one of the rasakalpa which is explained in rasaratnasamucchaya, and is is suggestive of its efficacy in Pandu roga. Pandu roga is a pitta pradhana vyadhi in which rasadhatu and rakta dhatu are mainly affected. According to modern texts, all disorders of vitiated digestion, absorption and assimilation can be considered under Pandu. Therefore, it can be said that Pandu is a very broad term comprising various rasa and rakt pradoshaj vikara such as anaemia, megaloblastic anaemia, blood disorders, leukemia’s etc. referring to this analogy, the test drug has been assessed for its efficacy against Chronic myeloid leukemia in an animal model. Method: Two groups containing 6 Xenograft SCID mice (of both sexes) each were taken. Mice in the control group were administered self-prepared test drug over a duration of 1 month to evaluate the efficacy. Mice in the placebo group received no treatment. Results: On the 29th day of the experiment mean tumour size size in the control group was 20.05 mm. whereas, the same in the study group was 5.26 mm. The depletion of platelet count and Hb% was also observed to be slower and minimal in the study group as compared to untreated mice having CML. Rate of increment of WBC’s was also comparatively reduced in Trailokyasundar rasa treated mice. Conclusion: The efficacy of Trailokyasundar rasa is highly significant as a remarkable reduction in the tumour volume and inhibition of further tumour growth was observed in the study animals. Trailokyasundar rasa can be assessed for its safety and efficacy using advance models and also the exact mechanism of action of the drug needs to be studied.

OA39 232. Successful Ayurvedic Management Of Chronic Alcoholic Hepatitis Complicated With Ascites: A Case Report Hardik Patel, Gupta SN

Alcoholic hepatitis is an intermediate stage in the spectrum of fatty liver disease, which range from benign steatosis to fatal cirrhosis. 10% of patients with steatohepatitis progress to cirrhosis over a time. The present case is of a 29 years old female suffered with chronic alcoholic hepatitis complicated with ascites. The patient was presented with symptoms of severe weakness, decreased appetite, pain in right hypochondrium, mild fever, breathlessness, vomiting, constipation, lower extremities oedema, severe icterus and increased abdominal girth. Abdominal ultrasound revealed hepatomegaly with diffuse fatty infiltration and possibility of liver parenchymal disease. Pseudocysts formation with mild atrophy of pancreas, mild splenomegaly. According to ayurvedic analysis, there was involvement of all the Doṣas with dominance of Pitta and Vāta. Āyurveda describes such condition as madātyaya. The patient was treated with Vardhamāna Pippalī, Katukī cūrṇa, Punarnavādi Kvātha, Bhṛṅgarāja cūrṇa, Ārogyavardhinī rasa, mixed powder of Bhūmyāmalakī, Śarpuṅkhā and Śveta Parpatī. Daśāṅga lepa is applied on abdomen to release abdominal discomfort. She was supplemented human albumin twice during the period of 60 days as an inpatient. Frusemide 40mg which she was taking before coming to us continued for one month and then stopped seeing good urine output and reduction in abdominal girth. After the treatment there was significant improvement in the condition of patient bringing severity from Child-Pugh stage C

Book of Abstracts 80 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine to stage A along with improvement in sign and symptoms. In laboratory findings total bilirubin level decreased from 25mg/dl to 2.6mg/dl. Presently patient is in follow up as outpatient.

OA40 250. Successful Management Of Ankylosing Spondylitis With Ayurvedic Interventions - A Case Report Dhanya KV, Vasudevan Nampoothiri MR, Sasikumar VK

Rationale for this case report: In addition to the obvious deleterious effects on quality of life, there is also a substantial economic burden associated with AS. It is estimated that AS affects about 0.5% of the population and male to female ratio is roughly 2:1. (AS) is the prototype disease within the (SpA), a group of diseases presenting mainly with inflammation of the axial skeleton. Presenting Concerns: A 28 year old man was admitted for bilateral knee joint pain, difficult to stoop, unable to walk without support and was diagnosed as A. S involving hip and bilateral knee joint pain, according toESSG , as well as AMOR Criteria. Interventions: He was referred to explore the possibility of Allopathic treatment, to a centre but there was no progress, and subsequently enrolled in the surgery clinic. At this point, Ayurvedic treatment was started and the patient responded positively. Main Lesson [s] from this case report: This case study reports the recovery of a case diagnosed as A. S involving Hip and Knee joint. X-ray of pelvis on the day of admission shows advanced degenerative changes with subchondral cyst and fragmentation , femero accetabular space shows only a narrow streak visible in the middle pole. After one month treatment again X-ray was taken, in that head of the right femur shows reduced fragmentation and marginal irregularity of acetabulam reduced. This reveals the scope of Ayurvedic management in A.S. Radiological as well as clinical symptoms according to the criteria were improved after Ayurvedic management.

OA41 255. Sensitivity Of Heart Rate Variability In Detecting Diurnal Variations Of Doṣa Dominance - A Pilot Study Sruthi Nambiar, James Chacko

Introduction: Heart rate variability (HRV) is the physiological phenomenon of variation in the time interval between heartbeats which is directly related to the body's interdependent regulatory systems. Doshas govern our biological clock and follow a circadian rhythm and by this rhythm all the metabolic functions of the body are regulated. The energies of these Doshas are different at different times of the day like Kapha Dosha is predominant during morning, Pitta Dosha in the afternoon and Vata Dosha in the evening.The aim of this study is to assess the reliability of Heart Rate Variability in a day. Methods and Design: The frequency patterns of Heart Rate Variability recorded using Vedapulse represent the status of Doshas graphically. For this; thirty healthy volunteers, aged 20-23 years of Amrita School of Ayurveda were recruited for spectral analysis of Heart Rate Variability (HRV) using Veda Pulse ; where two electrodes are placed on the right and left wrists of the participant, which are connected to the Veda Pulse Device. The device is connected to a computer, which captures the signals from the device through a software program and interprets the status of Doshas Discussion: From the study, it was observed that Vata Dosha remains almost constant throughout the day; whereas other two Doshas tend to vary slightly. Pitta dosha is found to decrease gradually during the day and

Book of Abstracts 81 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Kapha Dosha is having the tendancy to increase. The above variation may be due to body’s regulatory mechanism to maintain the Dosha in normalcy with respect to the external envioronment. Vata Dosha by remaining constant is maintaining Pitta and Kapha Dosha for performing their respective functions in the body.

OA42 263. Integrated Approach For The Management Of Fournier’s Gangrene (Kotha) - A Case Study Manoj Ranjan Meher, Gopikrishna BJ, Avnish Pathak

Fournier's gangrene is a rare, but life threatening surgical emergency seen all over the world. It is a fulminate form of infective necrotizing fasciitis of the perineal, genital, or perianal regions. With the newer advancement of surgical techniques and critical care medicine, the mortality and morbidity of this disease has come down significantly over a period of time. An early diagnosis including evaluation of predisposing and etiological factors, metabolic and physiological parameters with prompt resuscitation, aggressive surgical debridement, broad- spectrum antibiotic coverage and continuous monitoring of all the parameters is essential for a good outcome, therefore reducing the high mortality and morbidity of this condition. In the present paper Chedana Karma (early and aggressive surgical debridement) of the scrotal gangrenous tissues was done followed by Shodhana Karma (daily cleaning and dressing) with Panchavalkala Kwatha and application of Jatyadi Taila for Ropana Karma (wound healing). On the basis of Pus Culture and sensitivity broad-spectrum antibiotic coverage and continuous monitoring is done. The use of Ayurvedic formulations (Shasti Upakarma) after surgical debridement helped in early granulation tissue and epithelialization. So, here an attempt is made to present the concept of integrated approach for the management of fournier’s gangrene (Kotha).

OA43 271. Role Of Chakshusya Rasayana (Neuroprotection) In The Management Of Progressive Glaucomatous Optic Neuropathy- A Clinical Study Veeranagouda Adoor S, Dhiman KS and Amith Mehta J

Open Angle Glaucomatous Optic Neuropathy (OAGON) is one of the Neurodegenerative disease affecting Optic Nerve leading to a Progressive Visual Loss and irreversible blindness. The disease progresses inspite of good Intra Ocular Pressure by present available treatment modalities.With this the concept of Neuroprotection in Glaucomatous Optic Neuropathy (GON) came. The Patalagata Timira and GON have many similarities in their aetiopathogenesis. The Neurodegenerative disorders are mainly caused due to the Vata Prakopa as main pathological factor.Chakshusya-Rasayana is indicated in many degenerative disorders of eye.Keeping in mind the chronicity and complexity of the disease pathogenesis a classical approach was adopted as described in Vataja Patalagata Timira chikitsa sutra of Vagbhata. In this randomized controlled clinical study, a total of 102 patients were registered. Selected patients subjected for the complete ophthalmic examination.Eleven patients dropped. 91 patients completed the study. In Group A(Trial group) 45 patients given Vataja Patalagata Timira Line of management following by oral administration VARA FORTE POWDER 3gms once a day at night with Triphala Ghritha. In Group B(Control group) 46 patients treated with topical Brimonidine 0.2% once a day Eye Drops. The study duration 3months and follow up period 3 months. The base line values of Best Corrected Visual Acuity, Applanation Tonometre readings, Visual Field Examination, Retinal Nerve Fibre Thickness were compared with post treatment values which shows statistically significant percentage of improvement in Trial Group A compared to the Control Group B.

Book of Abstracts 82 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

The study proved that progression of GON can be better managed by classically adapting Chakshusya Rasayana strategies.

OA44 278. Integrative (Ayurveda) Oncology: Where We Are And Way Ahead Manohar Gundeti, Amrish Dedge, Govind Reddy, Srikanth N

Purpose:Conventional cancer chemotherapy and radiation have toxic side effects resulting in the limitation to their effective use, affecting the quality of life and large expenditures. Cancer Multidrug resistance is another reason leading to search for alternative treatments. The upsurge in use of CAM among cancer patients warrant evidence of safety and effectiveness of these interventions as the concomitant to conventional cancer therapy. Oriental countries and scientific bodies like NCCIH, SIO are in the endeavor of Evidence-Based Integrative care. This paper aims at a review of published/unpublished data for the effectiveness of Ayurveda/ herbal interventions as stand-alone or concomitant in the management of cancer. Further, we discuss the scope, challenges, and propose the future strategy for Integrative (Ayurveda) Oncology (IAO). Method: A thorough review of published case reports, clinical trials through the search engine like PubMed, AYUSH Research Portal etc., journals, reports along with unpublished data from IAO institutes. Results: National Cancer Institute (USA) through ‘Best Case Series’ vetted few case reports of Ayurveda/ herbal interventions as stand-alone with encouraging outcome. Ginger, Ashwagandha, Honey, and Rasakalpa as concomitant were effective in amelioration of chemotherapy and radiation toxicities. Our unpublished data shows increasing trend for Ayurveda as a concomitant to conventional curative or palliative care to reduce the toxicity. Conclusion: IAO has huge potential, however, there is a need to generate evidence and National Ayurveda Cancer Grid (NACG) may be a platform for this purpose wherein ‘Common Ayurveda Integrative Treatment Protocols’ designed based on the categorization of cancer patients.

OA45 280. Molecular Analysis Of Epidermal Growth Factor Receptor (EFGR) Gene Expression In Different Grades Of Gliomas: Critical Oncogene For Therapy Using Medicinal Plants Serene Xavier, Sundaram KR, Dilip Panikar, Shantikumar Nair, Krishnakumar Menon, Lakshmi Sumitra Vijayachandran

Glioblastomas / brain tumors are marked by increased aggressiveness which confers resistance to standard treatments and progressively transform them into neurologically destructive tumors. These features are driven by aberrantly functioning oncogenes involved in multiple deregulated signaling pathways. One such oncogene is epidermal growth factor receptor (EGFR), an important tyrosine kinase receptor which drives tumor invasiveness and resistance. Medicinal plant products like curcumin have the potential to modulate the activity of EGFR in cancer cells. In this present study, we aimed to evaluate the expression levels of EGFR and compared against the clinical grades of glioma. Gliomas (n=25) were histologically confirmed and graded according to WHO grading system. Gene expression levels were assayed using real-time PCR and compared against the glioma grades using statistical tools. Significant upregulation in messages of EGFR (p < 0.05) was observed among the glioma patients. Importantly, EGFR (r=0.617; p < 0.01) showed significant positive correlation with the clinical grades of glioma. Therefore, from our analysis, the potential correlation between levels of EGFR with glioma grades was demonstrated. Hence, analysis of gene expression profiles on larger patient data sets will help define the molecular epidemiology / pathology of glioma and aid in stratification of patients for personalized medicine involving multi- targeted drugs/ immunotherapies / medicinal plant products.

Book of Abstracts 83 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

OA46 281. A Prospective Study On The Effects Of Ayurvedic Massage In Post-Stroke Ravi Sankaran, Ravindranath Kamath, Anandkumar A

Objective: To objectively measure differences between patients with stroke who received Ayurvedic massage in addition to standard Physiotherapy (PT) versus those who received only standard PT. Design: Prospective case control trial. Participants- Fifty-two patients undergoing acute inpatient rehabilitation were prospectively followed post stroke. Twenty five received Ayurvedic massage within 1 month from stroke with standard PT and twenty seven received only PT. Setting: Tertiary level hospital, Neuro-rehabilitation unit Duration: 2014- 2017 Intervention: All patients received 6 hours of physical therapy averaged over a week. Massage was delivered daily for a total of 10 sessions followed by steam application. Measures: Brunnstrom Leg progression, spasticity using the Modified Ashworth Scale (MAS), time to achieve stand with minimal assistance, Functional Independence Measure (FIM) score for walking at discharge, use of antispastic drugs at discharge were followed. Patients were categorized as simple or complicated stroke based on events prior to rehabilitation. Results: Both simple and complicated patients who received Ayurvedic massage had lower MAS and need for antispastic drugs, achieved standing with minimal assistance sooner, and had better locomotion at discharge. All these differences were significant. Conclusion: Utilizing Ayurvedic massage in post stroke patients with flaccidity can promote faster standing with minimal assistance and lead to less need for antispastic drugs at discharge

OA47 292. Effect Of Dashamoola Ksheeravasti Over Gabapentin In The Management Of Diabetic Peripheral Neuropathy Raghavendra Shettar, Shikha Sikri

Purpose: The treatment of Diabetic Peripheral Neuropathy (DPN) can be a frustrating experience for both physicians and patients, and the clinically effective therapy on diabetic peripheral neuropathy remains elusive. In Ayurveda shoola or pain is explained in different contexts. Acharya Sushruta clarifies that any type of shoola will be influenced by Vaatadosha. Acharya Charaka advocates Dashamoola as a best Vaatahara medication. The purpose of this review was to investigate the effect of Dashamoola ksheeravasti in DPN. Method: In the present study 24 patients were randomly selected into two groups. Gr A consists of 12 patients received Vastichikitsa and all patients completed the course. Whereas in Gr B out of 12 patients 10 patients received Gabapentin(titrated from 900 to 3600mg/day) and 2 patients discontinued course. The primary pain was measured and assessed with 11-point Likert scale. Secondary measures includes the SF-McGill pain questionnaire score, SF – 36 Quality of life questionnaire score. Results: Gr A patients i.e. trial group shows good improvements (61.2%), where as Gr B, (control group) patients shows 62.8% improvement. Primary assessment parameter 11-point Likert scale shows statistically highly significant in both groups. Conclusion: Diabetic peripheral neuropathy can be best controlled by Dashamoola Ksheeravasti. Comparative to Gabapentin Dashamoola ksheeravasti is equal effective in controlling pain and numbness. Long term usage of Vasti

Book of Abstracts 84 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine chikitsa will definitely helps in preventing DPN complication.

OA48 296. Musa Paradisiaca-The Anticalculus Agent: To Explore The Unexplored Biju Balakrishnan, Nicky Haridas, Pallavi Menon, Jayachandran Perayil, Lakshmi Puzhankara, Rajesh Vyloppillil, Angel Fenol, Mohammed Shereef, Anuradha Bhaskar, Maya George, Reshma Suresh

Context: The litholytic effect of various plant products in the treatment of renal calculi has been validated. Plant and plant products have also been used in assuaging various ailments affecting the oral cavity. The role of Musa Paradisiaca, a litholytic and lithotriptic agent, as an anti- dental calculus agent is an unexplored territory. Aim: To assess the litholytic effect of Musa Paradisiaca on supra gingival calculus. Settings and Design: In vitro study. Materials and methods: Supragingival calculus was collected from lingual aspect of lower anterior teeth and placed in a closed vial holding 1.5 ml of Musa Paradisiaca (Stem juice) as the test sample and in a vial containing distilled water as the control. Beckman Caulter fully automated analyser was used to analyse the calcium, magnesium, phosphorous levels in the test and control sample at baseline, 7 days and 14 days. Result: Musa paradisiaca(stem juice) showed significantly higher levels of calcium (Ca), magnesium (Mg) and phosphorous (P) (Ca-52mg/dl, Mg-37mg/dl, P-4mg/dl) compared to that of the control sample (Ca-3.9mg/dl,Mg- 0.99mg/dl, P-0.4mg/dl). Conclusion: This study shows that the Musa paradisiaca juice has the impending ability to dissolute dental calculus. Studies that encompass various other aspects, such as the effect of Musa paradisiaca juice on tooth mineralisation, the method of delivery of the agent to the site of possible calculus accumulation etc. should be carried out to avail the use of this economical and easily available material as an anti-calculus agent.

OA49 300. Effectiveness Of Adjunct Ayurvedic Treatment In Cancer Control, And Improving Well-Being In Rare And Advanced Cancers Sameer Gore, Dhananjay Deshpande, Sushama Bhuvad, Pradnya Tilekar, Sanjog Awalkanthe, Bhuvnesh Sharma, Sadanand Sardeshmukh, Vineeta Deshmukh

Purpose: Rare cancers like breast cancer in males and advanced cancers have poor prognosis, though treated conventionally. Usefulness of adjunct Ayurvedic treatment in such cases is documented in study. Method: 1. Disease free survival is compared with Relative Survival Rate in similar types of cancers 2. Quality of life is assessed by QLQ C30 and Karnofsky score Research: Case reports of rare and advanced cancer patients treated with Ayurvedic treatment – A. 83 year, Female,Ca(Rt) Breast stage III,20 years disease free survival. 10 years RSR - 31 %. B. 48 year, Male, Teratoma of testis (choriocarcinoma) Stage IIA with aortocaval lymphnode Metastasis, under remission for 17 years. 5 years RSR - 73 %. C. 49 year, Female,Ca (Rt) Breast - TNBC with lung metastasis, under remission for 5 years. 5 year RSR(stage IV TNBC) - 22%. D. 32 year, Female,Ca (Lt) Breast with axillary LN mets, BRCA 1 mutation,disease free survival for 5 years, delievered a healthy child after Ayurvedic treatment. Survival rates are worse in such cases. E. 62 year, Male, Ca (Lt) Breast, Stage III, disease free survival of 6 years. 5 years RSR – 58.10%. F. 58 year, Female, High Grade Metastatic Adenocarcinoma in peritoneal lymph node with Liver mets, under remission for 10 years. 5 yrsRSR - 5-10%.

Book of Abstracts 85 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

G. 77 year, Female, Multiple Myeloma, under remission for 13 years, 5yrs RSR - 46.87%. Conclusion: Long term adjunct Ayurvedic treatment in the form of Shamana, Shodhana and Rasayanachikitsa is beneficial for cancer control and maintain well-being

OA50 301. Assessment Of Role Of Panchakarma And Allied Procedures In Management Of Side-Effects Of Radiotherapy In Oral Cavity Cancer Patients Shweta Gujar, Sadanand Sardeshmukh, Vineeta Deshmukh, Arvind Kulkarni, Sudha Gangal, Renuka Gayal, Swapna Kulkarni, Sushrut Sardeshmukh

Purpose: Radiotherapy is a treatment of choice in oral cavity cancer. Though essential, it produces lots of untoward long-lasting side-effects.The study was undertaken to assess role of Panchakarma and allied procedures in management of side-effects of Radiotherapy in these patients. Method: A. 40 patients of oral cavity cancers (CA Buccal mucosa – 13, CA Tongue – 10, CA Alvelous – 7, Other site – 10), age group 25 to 80, of both sexes and of all stage and grade were treated after completing radiotherapy. B. Treatment protocol - 7 days Panchakarma and allied procedures -Basti (Dashamool oil – 40 ml) and Nasya (Yashtimadhu oil – 4 drops) along with allied procedures like Gandusha (Triphala, Haridra decoction), Mukhapratisaran (YashtimadhuGhruta), Shirodhara (Jatamansi oil) and Karnapoorana (Dashamool oil). C. Assessment criteria – before and after Panchakarma Radiotherapy side-effects (Graded as per CTC of EORTC); Hb%, WBC, Platelets, Karnofsky score and QoL (Assessed by QLQ C30) Results: Extremely significant improvement in local pain (p=0.0009), very significant improvement in stomatitis (p=0.0045) and Hb% (p=0.008); significant improvement in xerostomia (p=0.465), trismus (p=0.0442), dysphagia (p=0.0307), WBC count (p=0.2), functional (p=0.0352) and symptom score (p=0.015). Significant improvement -not seen in loss of appetite, loss of taste, excessive salivation, platelet, Karnofsky and Global score. Statistical test :- students t test. Conclusion: Panchakarma and allied procedures mentioned in ShashtiUpakrama of Vrana are effective in management of long lasting side-effects of radiotherapy, which are mainly associated with Sira – Snayuaakunchana due to Vataprakopa and Shotha (inflammation) due to Pittaprakopa.

OA51 302. Effect Of Krumighna And Erandamuladi Basti Chikitsa On Quality Of Life In Cancer Patients Abhishekh Salunkhe, Renuka Gayal, Sadanand Sardeshmukh, Vineeta Deshmukh, Shweta Gujar, Arvind Kulkarni, Dhananjay Deshpande

Purpose: To assess effect of Krumighna&Erandamooladibastichikitsa in improving quality of life (QOL) of cancer patients. Method: A. 30 cancer patients from various stages, age 12-70yrs, of both sexes who have completed conventional cancer treatment and were under oral Ayurvedic medicines (OAM) were treated with Panchakarma treatment (BastiChikitsa) for 14 days (CA Breast, CA Cervix, CA Uterus, CA Tongue, Ca Endomwtrium, CA Brain, Malignant Melanoma etc) B. Treatment protocol: Basti treatment was given in following order 1) Krumighna (Karanj oil + Nimb oil + Nirgundi oil) anuvasanabasti (60ml) for 3 days 2) Krumighna (Karanj+ Nimb+ Nirgundi) anuvasana (60 ml) &Krumighna (Vidangadi) niruhabasti (450ml)

Book of Abstracts 86 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine alternate for 4 days 3) Erandamuladianuvasana (60 ml.) &niruhabasti (450ml.) alternate for 7 days C. The assessment criteria includes Clinical assessment, Karnofsky Score for performance status; along with Quality of life (QOL) assessment using QLQ C30 questionnaire Results: There is significant increase in Karnofsky score, Functional Score of QOL and Global score of QOL with p < 0.05 after Basti treatment. Also significant decrease in Symptom score of QOL with p < 0.05. Statistical test applied – Students paired t test. Conclusion: Bastichikitsa is effective in improving quality of life and minimizing cancer related as well as chemotherapy and radiotherapy toxicities related symptoms in cancer patients.

OA52 305. Effectiveness Of Ayurvedic Medicines In Reducing Adverse Effects Of Chemotherapy And Improving Quality Of Life Of Breast Cancer Patients Vasanti Godse, Shweta Gujar, Sadanand Sardeshmukh, Vineeta Deshmukh, Arvind Kulkarni, Tushar Patil, Sudha Gangal, Swapna Kulkarni , Anjali Deshpande

Purpose: Chemotherapy is a vital treatment in breast cancer followed by surgery. It has several long lasting adverse effects. The purpose of this study is to assess effectiveness of Ayurvedic medicines in reducing this adverse effects and improving QoL of breast cancer patients. Method: 137 breast cancer patients,stage I –III, age 18-65, previuosly undergone surgery and scheduled for chemotherapy were treated with OAM during chemotherapy and further for 6 months. Ayurvedic medicines – 1. Morning – Evening MauktikyuktaKamadudha – 500 mg + MauktikyuktaPravalPanchamrut – 500 mg with Ghee 2. After Lunch and Dinner – AnantaKapla – 5gm with water Assessment was done before 1st chemotherapy (A), at the end of chemotherapy (B) and at the end of year 1 (C). Result: Statistically no significant difference was observed at timepoint B& C when compared with A for Heamograms, LFTs, KFTs, CA 15.3 & weight. This indicates maintenance of biochemical parameters& weight during the course of Chemotherapy & there after till one year when treated with adjunct OAM Kernofsky score was also maintained during the course of Chemotherapy & found to be extremely significant (p=0.0072) when compared with timepoint C to A. Similar observations were seen for symptom score, global score, functional score (p<0.0001) of QLQ & Breast score (p=0.0006). This indicates maintained QoL during chemotherapy and better improvement as well as disease control at the end of year one. Conclusion: Oral Ayurvedic medicines are effective in reducing adverse effects of chemotherapy and improve quality of life in breast cancer patients.

OA53 306. Role Of Adjunct Ayurvedic Treatment In Increasing Disease Free Survival And Improving Quality Of Life In Cancer Patients Shrinivas Datar, Swapna Kulkarni, Nilambari Patil, Amruta Salunkhe, Suchita Vaidya, Anita Shingte, Vijay Radye, Sadanand Sardeshmukh, Vineeta Deshmukh

Purpose: In spite of conventional cancer treatment, disease free survival in certain cancer types varies from few months to 1 – 2 years with hampered Quality of Life (QoL). Adjunct Ayurvedic treatment is found to be effective in terms of increasing disease free survival and improvement in QoL. Method: 1. Disease free survival is compared with Relative Survival Rate or Median survival period in similar

Book of Abstracts 87 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine cancer types. 2. QoL- assessed by QLQ-C30 designed by EORTC and Karnofsky score before and after treatment. Result: Case reports of patients treated with adjunct Ayurvedic treatment –A. Male, 83 years, HCC, 14 years disease free survival and improved QoL. In spite of chemotherapy 5 years RSR 8.87 %. B. Female, 60 yrs, High grade Adenocarcinoma of ovary, Stage IV, remission 10 years. 5 years RSR 17 %. C. Female, 43 years, Cortical Thymoma, under remission for 10 years. 5 year RSR 71% D. Male, 25 years, ALL, disease free survival 15 years. 5 yrs RSR in cases of adult ALL is 42% E. Female, 72 years, CA Oesophagus- disease free survival 18 years.5 Yrs RSR – 20.3 % F. Male, 65 years Malignant Melanoma, disease free survival 19 years. Reported 5 years RSR – 59% and 10 years 48% G. Male, 80 years, CA stomach with liver metastasis, disease free survival of 13 yrs 8 months. Median overall survival - 6 months. Conclusion: Adjunct Ayurvedic treatment in form of Shamana, Shodhana and Rasayana Chikitsa is effective in increasing disease free survival and improving QoL.

OA54 312. Understanding Cancer And Its Integrative Management Rabinarayan Tripathy, Susmita Priyadarshinee Otta

Background: Cancer being the leading cause of death is a global challenge, as nearly three millions of patients are suffering at present and every year approximately a million new cases are reported. The contemporary cancer therapy is burdened by drug-induced toxic side effects. Hence a safe and effective mode of treatment is needed to control the cancer development and progression Method: In this review, the understanding of cancer was summarized on the basis of Ayurvedic doctrine by referring various data bases. Result: Ayurvedic doctrine understands cancer as the derangement of tridosha as a whole of neuro-humoral, metabolic and nutritional imbalance that causes loss of mutual coordination in homeostasis resulting critical condition in tissue proliferation. Ayurveda defines these changes as “ARBUDA” a mass of tissue growth or solid tumor independent of function. Because of continuous intake of aggravating factors, initially dosha samurchhana happens. That samurchhita dosha vitiates the mamsa dhatu at any part of the body. As a result of neurohumoral, metabolic and nutritional derangement that amount of mamsadhatu (kwachideva mamsa) will starts proliferate with Lack of cellular differentiation, Pleomorphism – variation in size and shape, Anisocytosis, Anisonucleosis and Abnormal mitotic activities. The decrease in agni is inversely proportional (Apaka) to the related tissue and therefore in arbuda, the decreased state of dhatwagni (deranged metabolism) will result in excessive tissue growth. At this juncture a natural remedial and preventive approach is the demand of the society to combat the altered homeostasis. Conclusion: Ayurveda emphasises some herbo-mineral medicaments, purificatory therapy, immunomodulators and holistic life style adaptation to cure, prevent and improve the quality of life.

Book of Abstracts 88 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

CONFERENCE ABSTRACTS

Scientific Abstracts Presented at Amrita Samyogam 2017 Amrita Institute of Medical Sciences, Kochi, Kerala on 6 and 7, August, 2017

POSTER PRESENTATIONS

PAO1 3. Effect Of Shilajatu Rasayana In Letrozole Induced Polycystic Ovarian Syndrome Kashinath Hadimur

The major cause of female infertility in recent years is polycystic ovarian syndrome commonly called as PCOS, compared to yonivyapath (disorders of female reproductive system) described in Ayurveda. Shilajatu Rasayana herbo-mineral preparation mentioned in “Rasendra Chudamani” indicated in yonyaamaya (disorders of female reproductive system), gulma (tumors), meha (hyperinsulinemia), pandu (anemia), etc. is expected to contribute positive and better result in letrozole-induced PCOS, considering the previous analytical and experimental studies. Letrozole, Shilajatu Rasayana, clomiphene citrate, ghee, and female albino rats formed the materials for the study. Totally thirty female rats were initially induced to develop PCOS by injecting letrozole. The induction of PCOS in rats was checked through vaginal smear analysis and further confirmed by hormonal assay. PCOS-induced rats were treated with clomiphene citrate (standard), Shilajatu Rasayana (test drug), and ghee (control). Ovarian and uterine weight, hormonal assay, and histomorphometric changes were observed and recorded. Shilajatu Rasayana has shown a significant result in letrozole-induced PCOS by regulating hormones, reduction of cystic follicles, maturation of ovarian follicles, and decreasing the increased ovarian and uterine weight. (Structure abstract into P, M, R, C)

PAO2 16. Treatment Of Glaucomatous Optic Atrophy Through Ayurveda : A Case Study Pratibha Upadhyay, Shamsa Fiaz

Optic atrophy is damage to optic nerve hence ultimately causing degeneration of the optic nerve. Optic atrophy, , due to the pale appearance of the optic nerve head when the etiology is glaucoma that is the end stage manifestation of the disease that causes complete loss of vision at the end. usually only central or tunnel vision remains. This disease accounts for one of the major cause of blindness among all.so whole world is facing better treatment regarding this as it is the silent killer .Ayurveda has been serving to the humanity since very ancient times, so it can be better alternative to such disorders that are so disastrous to the vison . in ayurveda , there is a vast description of eye diseases having their treatment in detail.but the basic thing is that it s principle rely on dosha, dhatu, samyata .that is the balance between body humour and tissues .hence the line of treatment also aims at balancing the same .and this is the reason why a and how ayurveda aims at eliminating the disease and not just suppressing the cause . so keeping in view this point a challenging case of glaucomatous atrophy was chosen for treatment through basti with mahamasha taila and tarpana therapy with jeevantyadi ghrita that resulted in Book of Abstracts 89 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine improvement of vision from hand movement to finger count in right eye and from 5/60 to 6/60 in left eye.in duration of 3 months.

PAO3 21. In Vitro Drug Release And Study Of Anti-Inflammatory Effect Of Rasna Saptak Kwath As Topical Drug Shruti Pandey, Anand Chaudhary The Indian system of medicine has a number of formulations for different diseases. Among them Rasna Saptak Kwath (RSK) is an Ayurvedic polyherbal formulation in decoction form which is indicated to arthritis patient orally to relieve inflammation and pain. It contains eight herbal drugs viz. Pluchea lanceolata,, Tribulus terristris, Tinospora cardifolia, Boerrihia diffusa, Ricinus communis, Cedrus deodara, Cassia fistula and Zingiber officinalis. Advancement in Ayurvedic pharmaceutics is the demand of time. This study was carried out with the aim to available this oral dosage forms into topical drug. So, this study was perform to evaluate, anti-inflammatory effect of solid extracts obtained from RSK and to check the permeability of extract by in vitro-diffusion study. The extractions of these herbs were carried out by two methods. The first extraction was carried out in hydro-alcoholic (50:50) media, while another was done through the classical decoction method. In vitro drug releases of these extracts were assessed through the Franz diffusion cell by using rat skin. Gallic acid was taken as a standard component. The obtained extracts were tested for its anti-inflammatory effect in carrageen induced oedema model. Result in vitro drug release showed more concentration of Gallic acid in receptor media in which aqueous extract was used while hydro-alcoholic extract showed marked effect in comparison aqueous extract, in carrageenan oedema model. Further investigations for these extracts will be carried out to develop topical or transdermal dosage form

PAO4 22. Distillation As A More Potent Alternative To Decoction Of Jati (Jasminum Grandiflorum) As A Mouthwash Geethu Balakrishnan, Arun Mohanan, Ramesh NV

Rationale:Jati decoction has been attributed with various properties in curing and preventing oral diseases. Considering the factors of patient compliance, convenience of usage, storage and optimization of the action, a mouthwash was prepared with alternative method of distillation, a method accepted in Ayurvedic classics as Arka kalpana.Eventhough many Ayurvedic mouthwashes are available in the market, rarely one has been scientifically rigorously validated. Purpose: The purpose of this study was to compare the physico-chemical parameters of the distillate and the decoction and to determine whether there would be a significant change in physico chemical profile implicating the alternative regarding its safety and efficacy. Methods: Both decoction and distillate were analysed with TLC and GC-MS techniques.TLC was performed on silica gel ‘G’plate using toluene: ethyl acetate (1:1) as mobile phase and heating the plate for 10 minutes. Results: TLC of the distillate showed five spots at Rf values 0.37 (violet), 0.52, 0.76 (both light blue), 0.81(pink), 0.91(blue). Further studies using the recent analytical techniques, GC-MS showed that out of the 17 peaks detected for the distillate, the two major peaks were that of THYMOL & CARVACROL. These two specific peaks were however absent in the GC-MS of decoction. Conclusion: Jati decoction has already proven its analgesic and anti-inflammatory activity. The distillate, with the presence of THYMOL & CARVACROL as active principles, potentiates the analgesic, anti-inflammatory, anti- oxidant

Book of Abstracts 90 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine and anti microbial activities of the preparation. Thus optimal benefits in oral care could be obtained with the distillate, rather than the decoction.

PAO5 23. A Clinical Study On The Effect Of Ayurvedic Management Of Kācha With Special Reference To Immature Senile Cataract Surangi KGa, Shamsa Fiaz Shalakya Tantra is one among the Ashtanga Ayurveda; which deals with diseases occurring above the clavicle specially the sensory organs. The disorders which cause partial or complete visual disturbances are known as Drishtigata Roga. As per Vagbhata, 3rd Patalagata Timira is known as Kācha which is characterized by gradual loss of vision and Rāgaprāpta Drishti (coloured visual/pupillary area). In cataract the crystalline lens become coloured due to opacifications and the main feature of immature cataract is gradual diminished vision. Hence 3rd Patalagata Timira can be correlated with the Immature Senile Cataract. Cataract is the world’s leading cause of blindness affecting an estimated 20 million people. This is expected to increase to 50 million by the year 2020. In this regard current study was carried out with the aim of to evaluate the role of Navapatala Varti Anjana along with Śatāvaryādi Cūrņa in the management of Kācha. Trial was conducted with 30 patients attending the OPD and IPD of Shalakya Department of NIA, Jaipur as per the exclusion and inclusion criteria. Assessments were done before (BT) and after (AT) completion of treatment and after the follow up (AF) period with SPSS 2016 and Microsoft Excel 2007. All the chief complaints got statistically highly significant results. Statistically highly significant results were found in visual acuity and PSC type of cataract while Nuclear and cortical type of cataract received statistically significant results. Hence immature cataract can be successfully managed by the selected medicines.

PA06 28. An Invitro Study Of Yograj Churna On Antioxidant Activity Shikha Lekharu, Khagen Basumatory

Background: Cellular damage induced by free radicals like reactive oxygen and nitrogen species has been implicated in several disorder and diseases including anemia. Hence naturally occurring antioxidants rich herbs play a vital role in combating these conditions. The present study was carried out to investigate the invitro free radical scavenging capacity of a known Ayurvedic herbomineral formulation called yograj churna. Methods: Methanol extract of yograj churna were studied for invitro total antioxidant activity. Assays like DPPH , ABTS scavenging to evaluate radical quenching potential were performed. Results: The formulation has shown that IC 50 value for ascorbic acid was 5.6 and for yograj was 15.15 in DPPH. In ABTS , the IC50 value was 237.15 for ascorbic acid and 439.4 for yograj churna. Conclusion:In Indian traditional Ayurvedic system,use of Yograj Churna is in regular practice mainly combating anemia,poisoning,bronchitis,tuberculosis,obstinate skin disease,diabetes,asthma,anorexia etc and many of the rasayana are known for their free radical scavenging activity. Thus the study has validated the potential use of yograj churna as an antioxidant to fight diseases.

PAO7 29. A Single Case Study On Viral Retrobulber Optic Neuritis Nikita Baghel, Prabhakar Vardhan

A 21 year female patient presented with headache, fever,malise and vomiting since 3 days duration and was initial managed as a case of chicken pox .After 6 weeks she developed painless loss of vision in both eye. She admitted in

Book of Abstracts 91 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

RP Centre Dehli for 7 days, after treatment vision in Right eye was HM and Left eye was 6/36 .After 1 week she came to NIA Shalakya opd with C/O blurred vision for treatment .On ocutar examination vision in right eye was CF 2 m and left eye was 6/36 and fundus examination shows hyperaemic disc and no relative afferent pupillary defect . A provisional diagnosis of viral retrobulber optic neuritis( Timir) secondary to demyelination was made as MRI showed demyelinating plaques. Patient was started Saptamrita lauha, Trifala churna, Yograja gugull and Shunthi, Dhanyaka, Mustaka for Amapachana for 15 days and 2 sitting of Marsh nasya with Anutail and Tarpana with Patoladi ghrita for 1 month with in the gap of 7 days. After completion of treatment visual acuity of right eye was improved CF 2 m to 6/18 and 6/36 to 6/24 in left eye without glass and with glass it is 6/9 in both eyes. On follow up MRI at 3 months there was resolution of the demyelinating changes on MRI and the final visual acuity was 6/9P in Right eye and 6/9 in Left eye. This patient needs to be followed up to detect development of demyelinating diseases later in life.

PAO8 32. Perspectives Of Traditional And Allopathic Physicians On Spirituality And Its Role In Medicine: Historical Trends And Opportunity Of Convergence Towards An Integrative Medicine Akhilesh Shukla, Parameshwaran Ramakrishnan

Background: Traditional medicine continued its theory and practice grounded in spirituality/religion while allopathic medicine had alienated itself from spirituality/religion for a while. Allopathic medicine is now re-entering into this realm well equipped with their evidence based techniques of enquiry. Objective: We aim to understand the perspectives of AYUSH (Ayurveda, Yoga, Unani, Siddha and Homeopathy) and allopathic physicians on two key questions. (1) Is spirituality a scientific subject? (2) Is it worthy to be introduced as an academic subject into a health education program? Method: An international pilot study was conducted to collect the data from AYUSH (N=189) and allopathic professionals (N=198). Research questionnaires used were (1) Religion and Spirituality in Medicine: Physician’s Perspective (RSMPP), and a supplementary questionnaire on Spirituality as a Scientific Subject, (2) Professional Quality of Life and (3) General Health Questionnaire. Result: 84% of AYUSH professionals approved spirituality as a scientific subject and worthy to be introduced in medical school curriculum as compared to 64% of allopathic/modern medical professionals (p<0.005). Conclusion: AYUSH system can contribute significantly in the development of spirituality as a scientific academic subject but we need to utilize all available scientific tools of modern/evidence based medicine to bring this change. We believe this field of spirituality-medicine could also be the beginning of a truly integrative medicine.

PAO9 37. Management Of Aicardi Syndrome In Ayurveda – Case Report Senthiarasi Thamizhmani

Rationale for this case report: Aicardi syndrome is a neurodevelopmental disorder that affects primarily females.It is characterized by three main features – agenesis of corpus callosum, typical chorioretinal lacunae and infantile spasms.It is a very rare disorder .Researches estimate that there are approximately 4000 affected individuals worldwide.The cause is unknown but researchers believe that it is probably the result of a mutation in a gene on the X – chromosome.The outcome of AS is severe, with a high early mortality, considerable morbidity and a generally poor developmental outcome. This case report discusses the successful management with Ayurvedic treatment of a case diagnosed as aicardi syndrome.

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Presenting concerns: 3 years old female child admitted at Govt Ayurveda Medical College Hospital, in 2014 with the complaints of global developmental delay,no eye contact and subnormal intelligence. She is a diagnosed case of Aicardi syndrome. Interventions: Child developed seizure at her age of 5 months which continued till 3 years of age. She was on antiepileptic drugs and hence seizure attack was controlled but she didn’t attain the milestones like turning over, sitting, standing, walking, fine motor skills, social and language development. During this period ayurvedic treatment was started and the child showed good improvement. Outcome: Patient underwent four courses of ayurvedic panchakarma treatment with internal medications and improved well with each course of treatment by attaining the milestones. The child is able to perform her daily activities by herself. Lesson from this case report: this case study shows improvement in attaining developmental milestones with panchakarma procedures in a case diagnosed as Aicardi syndrome. This case study demonstrates the need for further studies to evaluate the outcomes of Ayurvedic interventions in developmental disorders of genetic causes.

PA10 45. Clinical Study To Evaluate The Efficacy Of Drakshadi Yoga In The Management Of Respiratory Allergic Disorders Of Children Devendra Kumar, Nisha Ojha

Purpose: During recent decades, there has been a dramatic rise in prevalence of respiratory allergic disease, which include asthma, eczema and allergic rhinitis. Children with Respiratory Allergic Disorders (RAD) experience a lot of problems in their day to day activities. Approximately 40% of children are affected by some form of allergy and respiratory allergies are the most common allergies worldwide. As per different etiological factors and symptoms of respiratory allergic disorders it can be correlated with Tamaka Shvasa and Pratishyaya in Ayurveda. Presently available medicines includes antihistaminic, bronchodilators, mast cell stabilizers and corticosteroids do not provide sustained relief. Methods: The study was conducted in 100 patients of RAD and randomly divided into two groups. In group A patients were treated with Drakshadi Yog (1ml/kg/day in 2-3 divided doses, orally), after meal for 12 weeks. In group B patients were treated with placebo (1ml/kg/day in 2-3 divided doses, orally) after meal for 12 weeks. Results: Statistical evaluations of overall morbidity features showed good result in group A patients, treated with trial drug (Syrup Drakshadi Yog). In nasal discharge, loss of smell, sneezing, nasal obstruction, headache, hoarseness of voice, itching of nose and eyes, wheezing, cough, inflammation of throat extremely significant improvement was seen in group A. Where as in other features such as fever and dyspnea very significant improvement was seen in group A. On the other hand, in control group (group B) all the outcomes were insignificant. Conclusion: The study drug “Drakshadi Yog” is effective in alleviating and reducing the morbidity score in RAD, as compared to the previous morbidity history. No adverse effect, of the study drug was observed during the study.

PA11 49. Treatment Option For Age Related Voiding Dysfunction In Ayurveda And Contemporary Sciences With Special Reference To Benign Prostatic Hyperplasia Rajeev Kumar Singh, Shiv Ji Gupta, Pradeep Kumar

Benign prostatic hyperplasia (BPH) is a condition due to anatomical changes in the prostate gland which later affects the voiding functions. As the disease occurs only in the elder age group, none prostatic causes also play an important role in the clinical manifestation of the disease. Lower urinary tract symptoms (LUTS) evocative of BPH

Book of Abstracts 93 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine can significantly affect quality of life. Men with bothersome LUTS/BPH often present with various other age-related conditions, including sexual dysfunction, heart disease, hypertension, diabetes, and the metabolic syndrome, which can complicate management decisions. Urinary bladder dysfunctions are due to poor coordination between the bladder muscle and the urethra, resulting in incomplete relaxation or over-activity of the bladder muscles during voiding. Voiding symptoms represent a continuum of what is referred to as Lower Urinary Tract Symptoms (LUTS). BPH is the most frequent cause of LUTS and significant cause of decreased quality of life. A better understanding of the prostate physiology and pathogenesis has lead to the development of promising agents, useful in the management of LUTS in men. BPH is very close to Vatastheela according to their symptomatology. Ayurvedic Literature descries diverse group of drugs and procedure for the management of Vatastheela. Department of Shalya Tantra managed such type of problem especially by Ayurvedic compounds and Basti Chikitsa since last 3 decades with encouraging results.

PA12 54. An Interventional Trial On Promotion Of Positive Health Through Seasonal Purification In Relation With Pitta Lakshmi V, Dilip Kumar K V

Purpose: It is a well-known fact that atmospheric changes occur with seasonal variations. These changes affect all individuals either beneficially or adversely. In order to prevent bad effects due to seasonal variations, Ayurveda proposes specific seasonal purificatory procedures. Seasonal purification in an appropriate time in accordance with the expected Dosha prakopa facilitates the promotion of positive health as well as prevention of diseases. With reference to pitta dosha, sarat is considered as the appropriate time for seasonal purification and a sneha sweda yukta virechana procedure is considered as the suitable sodhana procedure. Thus, sneha sweda yukta virechana in a pitta dominant phase enable us to prevent disorders due to pittakopa and results in the overall health promotion of the individual. The impact of seasonal purificatory procedure on various parameters were planned to study in order to derive a probable mode of action of preventive panchakarma procedure for the promotion of positive health as well as prevention of seasonal outbreak of diseases. Methods: Randomized controlled preventive trial was conducted in 30 healthy volunteers with 15 each in control and study group. Lottery method was adopted for randomization. The intervention provided in the study group was 1) Rookshana – 2 days by takrapaana 2) Snehapaana with Tiktaka ghrita 3) Abhyanga and ushma sweda for 3 days 4) Virechana with Avipathy choorna 5) Peyadi krama. Assessment was done day before rookshana and day after peyadi krama which included subjective parameters viz; WHO QOL (BREF), Ayurvedic Health Status Assessment, Pitta Rating Scale and Objective parameters viz; Hb, ESR, TC, DC, FBS, Lipid Profile, LFT, Antioxidant Enzyme Assay and Body weight. One month follow up was kept for evaluating the disease preventing potential of the intervention. Results: Statistically significant positive change was observed between the groups in psychological (p<0.01) and environmental domains (p<0.01) of WHO QOL (BREF), vata (p<0.05), pitta (p<0.001) and kapha (p<0.05) domains of Ayurvedic Health Status Assessment Scale, Pitta rating scale (p<0.05), total cholesterol((p<0.05), LDL( p<0.05), HDL(p<0.001), total bilirubin( p<0.05), direct bilirubin (p<0.05) SGOT (p<0.05), SGPT (p<0.05), alkaline phosphatase (p<0.05), GSH-0.1ml (p<0.01)and 0.2 ml (p<0.01)concentration of blood samples, SOD (p<0.01), GPX (p<0.05), lipid peroxidation (p<0.05). Statistically significant positive change was observed in study group in physical domain of WHO QOL (p< 0.001), TC (p<0.05), polymorphs (p<0.05), Hb (p<0.05), FBS (p<0.05), albumin (p<0.05), A/G ratio (p<0.01) and globulin (p<0.01) and body weight (p<0.001), which were statistically insignificant on comparison. Positive change observed in lymphocyte, eosinophil, monocyte, ESR, VLDL,

Book of Abstracts 94 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine triglycerides and total protein were statistically insignificant (p>0.05). Incidence of general health problems and its pitta association was found to be 80% and 88% respectively in control group, where as it was only 20% and 12% respectively in study group. Conclusion: The period from August to November in Kerala is an overlapped period of rain and sunshine and on a doshik analysis it was found to be a pitta dominant phase. Preventive seasonal purificatory procedure in this period brings about positive changes in the subjective and objective health parameters thereby resulting in promotion of positive health and prevention of pitta associated health problems.

PA13 55. Ayurvedic Intervention With Rehabilitative Therapies Improve Development In Children With Cerebral Palsy M K Lekshmi

Children having proper growth and development are the base of a nation‘s social and economic development. But the incidence of children with developmental disorders (DD) is on the rise.In India, sources have found prevalence of 1.5-2.5% of developmental delay in children under 2 years of age. Cerebral Palsy (CP) is the most important cause of DD. The management of CP is multidimensional and needs the services of pediatric neurologist, physiotherapist, speech therapist, occupational therapist etc. This requires a long term management and also depends on the parent’s socio economic status. The management of CP with Ayurvedic interventions like Snehapana (internal administration of medicated ghee), bahya sneha sweda (external oleation and sudation), murdha taila (oil application on head) and Vasti (medicated enema) integrating rehabilitative therapies has shown faster and sustained improvement in attaining milestones. The integrative management comprising Ayurvedic interventions and rehabilitative therapies has shown significant changes in the motor, social and intellectual disabilities. The pre and post evaluation of a series of twenty cases reported here with spastic Cerebral palsy between the age group of 1 to 10 years using Vineland Social Maturity Scale (P 0.000), Activities of Daily Living (P 0.000), Expressive language assessment (P 0.002), and Receptive language assessment (P 0.000), shows statistically significant results. The possibility of fat soluble constituents of the drugs crosses the blood brain barrier, enhancing nervous tissue regeneration and new synapse formation thereby fastening the attainment of milestone needs detailed investigations.

PA14 56. Pañcakarma Therapy In Cerebral Palsy (CP) In A Tertiary Care Hospital - A Case Report Sonam, Arun Kumar Mahapatra, Rajagopala S

Rationale for this case report: Children with CP have different type of physical disability, which depends upon the extent of involvement of brain damage. Children are not able to perform activities/ attain milestones on time as the other children of their age do. The symptom appears/diagnosed during the first 1- 2 years of life. Muscle relaxants like Baclofen are recommended for managing Muscle spasticity in CP. However, Long term administration of these muscle relaxants is associated with abuse potential and many adverse events. This case report discusses on the successful management with Ayurvedic interventions of a diagnosed case of cerebral palsy (CP) with satisfactory recovery. Presenting concerns: A 6 year old girl child attended All India Institute of Ayurveda (AIIA), a tertiary care Centre, with delaying in walking and spasticity in both legs. The patient was born at 29 weeks (Pre term) with LSCS having Low birth weight (LBW - 1.4 kg) and history of birth asphyxia. She was kept in nursery for 18- 20 days after birth. The features were suggestive of Cerebral palsy.

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Interventions: The patient has undergone treatment from different hospitals and was also operated for knee contractures (crossed legs) 2years back, but got no relief i.e. not started walking. At this point Ayurvedic Panchakarma procedures were started for 17 days, i.e., Udwartana with Kolakulatthadi churna for initial 3 days followed by Sarvanga Abhyanga with Ksheerbala Taila and Nadi Sweda with Dashmoola Kwatha for 14 days along with Matrabasti of Ksheerbala Taila (10ml) for last 7days. Such 2 courses were given with an interval of 2 months. Outcomes: The patient responded well to Ayurvedic Panchakarma procedures and started walking with support (2-3 steps) and improvement in sleep pattern along with overall improvement in the presenting complaints, which was evident clinically. Main lesson from this case report: The condition of CP has no cure in any medical system. CP can be compared with Vatavyadhi and Pañcakarma procedures like Udvartana, Abhyanga, Swedana, and Matra Basti along with internal medication helps in correcting the vitiation of Vata proves to be beneficial. In the present study the same approach was adopted and found to be beneficial. This case study demonstrates the need for further studies to evaluate the outcomes of Ayurvedic interventions in the management of CP

PA15 58. Ayurvedic Approach For Management Of Age Related Macular Degeneration (Non-Exudative Type) — A Case Report Poonam Jakhar , Shamsa Fiaz

Introduction: Age-related macular degeneration (ARMD) is the leading cause of irreversible visual impairment in the elderly. The prevalence of ARMD increases exponentially every decade after age 50. The loss of central visual acuity leads to a reduction in activities of daily living, as well as to mobility problems and an increased risk of falls, fractures, and depression in the elderly. Treatment for non-exudative type AMD consists of antioxidants and zinc and close monitoring which is still not proven to stop further degeneration. Ayurvedic therapies and oral medicines, in two cases, were directed towards alleviating symptoms and to stop further deterioration of vision. Methods and Materials: 73 years old male patient complaining of blurred vision since 5 years and another 64 years male complaining of blurred vision since 4 years attending Shalakya OPD of NIA ,was chosen having signs of non-exudative AMD. Therapy consisted of Marsha Nasya with Anu Taila, Akshi Tarpana with Jeevantiyadi Ghrita, Niruha Basti (enema with medicated decoction made from Chakshushya druga) , Anuvasana Basti (enema with Triphaladi Taila) in 3 sittings schedule along with oral Ayurvedic drugs for three months. Results: Patient’s condition was assessed for symptoms and at the end of three months showed substantial improvement. Discussion: The drugs selected here should be vata pacifying ,as well as pitta shamaka with Chakshushya, Balya and Rasayana properties that help in improving vsion and reducing the symptoms. This study shows the cases of AS may be successfully managed with Ayurvedic treatment.

PA16 64. Anti-Convulsant Effect Of Ksheerabala Taila In Albino Rats Nimmy VS, Jayasree P , Deepa MS

Introduction: Epilepsy is a chronic disorder which accounts for about 0.5% of world’s disease burden and is the third commonest disorder of central nervous system. Ayurveda therapies are most acclaimed in preventing the reoccurrence of seizure and bestowing health. Apasmara chikitsa is generally utilised in treating Epilepsy due to closeness in pathogenesis and symptomatology. Sneha kalpana including ghritha (medicated ghee) and taila (medicated oil) are of foremost relevance in managing this disease. The study seeks to reveal the role of

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Ksheerabala taila, a classical medicine used as rasayana in Epilepsy management. Methodology: Experimental studies on the anti convulsant effect of Ksheerabala taila by Maximum electroshock seizure method in albino rats both male and female (150- 200gm.) was carried out. The classical textbooks and modern research works were reviewed to support the findings of the study. Result: In chronic model Ksherabala Taila showed 80.638% and 63.21% protection against Tonic Hind Limb extension in MES induced seizures in therapuetic dose and half therapeutic dose respectively which is significant statistiscally. Discussion: Thus in condition like generalised seizures where there is predominantly symptoms of Vatika Apasmara, taila is to be used as rasayana for prevention of further seizures. The treatments that are conducted in this line have also reflected positive results. Many medicines and therapies in Apasmara have stood the test of time. Yet there lies a need to substantiate the logic behind them. This paper attempts to explore and showcase the pharmco-therapeutic considerations that are borne while managing epilepsy.

PA17 84. A Clinical Case Report On Meniere’s Disease Smina PB

Meniere’s disease is a disorder of the inner ear which often affects both hearing and balance of the body to varying degrees. It is characterized by episodes of vertigo, tinnitus and progressing hearing loss. This affects people differently, which range in intensity from being a mild annoyance to a chronic life-long disability. This case report evaluates the effect of Ayurvedic treatments in treating Meniere’s disease in a single patient who received both Op and Ip treatments resulting in the complete recovery. Meniere’s disease has been a subject of wide research today, since there is no cure and great deal of specialization has changed the very face of understanding and managing it. Lifestyle modifications are not well understood as playing a major role in the management of this condition. This provided an impetus to venture into possibility to find a therapeutic principle based on the fundamentals of Ayurveda and with this case study, it is being offered as an encouragement to other physicians so that they can test the efficacy of the above cited Ayurvedic regimen as and when they are presented with patients with Meniere’s Disease.

PA18 86. A Case Study Of SNHL (Tinnitus) Managed By Ayurvedic Treatment Ganga Hadimani

Rationale for this case report: In day today’s life perceptible some sounds in the ear makes very much annoying agony where individual fails to accomplish his routine. With much advancement in the modern medical science one could not have a better solution for tinnitus. This case report discusses the successful management with Ayurvedic treatment of a case previously diagnosed and treated for phonophobia. Patient is healthy and asymptomatic more than year after recovery. Presenting concerns: A 42-year old male was admitted to P.D.Patel Ayurvedic hospital at Nadiad (Gujarat) in March 2016 with the complaint of head ache & some added sounds in both ears more in the right ear which was progressive, and he was unable to withstand any type of sounds. The features were suggestive of sensory neural hearing loss. Interventions: His audiometric report shows sensory neural hearing loss (SNHL), rest of the other investigations are all within normal limit. He was clinically examined and at this point, Ayurvedic treatment was started and patient responded positively.

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Outcomes: The patient responded well to Ayurvedic treatment and recovered in the course of 45 days. Subsequent audiometric reports after Ayurvedic treatments revealed the marked improvement. Main lesson(s) from this case report: Patient started feeling very much comfortable & happy as he could hear other people’s conservation without getting irritated. After 45 days of treatment though his complaints were very much under control by Ayurvedic treatment he started showing improvement. This case study demonstrates the need for further studies to evaluate the outcomes of Ayurvedic interventions in sensory neural hearing loss because there is no any treatment in other system of medicine.

PA19 91. Study Of Phytochemical Constituents And Antioxidant Activity Of Beta Vulgaris Vandana Singh, Ramesh Kumar

Introduction: The beetroot (Beta vulgaris) commonly known as chukandar, is a vegetable plant and belongs to family Amaranthaceae. The roots of beet have long been used in traditional Indian medicine to treat a wide variety of diseases. The claimed therapeutic use of beetroot includes antitumor, carminative, emmenagogue, and hemostatic and renal protective properties. Beetroot is known to be a powerful antioxidant. In recent years, beetroot has gained popularity to be a natural food to boost the energy in athletes. It has been recommended for faster healing of wounds. Recent reports indicate that Beta vulgaris extracts (root) possess antihypertensive, hypoglycemic, antioxidant, anti-inflammatory, and hepatoprotective activities. Keeping in view of the above beneficial effects of beet root we sought to analyse the photochemical constituents present in the methanolic extract of beet root. Materials and Methods: We purchased the beet root (beta vulgaris) from the local market of Jhansi, Uttar Pradesh and methanolic exraction by soxlet method was performed. Result: Most of the phytochemical constituents such as alkaloids, reducing sugar, flavonoids, tannins, saponins, cardiac glycosides, protein and amino acids were present in the methanolic extracts. However, glycosides, terpenoids and steroids were absent. Methanolic extract shows the antioxidant potential. Conclusion: The present study shows that most of the phytochemical constituents are present in the methanolic extracts of Beta vulgaris and has the antioxidant potential.

PA20 93. Effect Of Palash (Butea Monosperma) On Ovary Of Mice – An Evidence Based Study Neelam Gupta, Shivji Gupta

Plants have been used worldwide for treatment of various human ailments since antiquity. In Ayurvedic practice Butea monosperma (Palash) is in clinical use for hundreds of years as a contraceptive. Seeds of Butea monosperma are also used as an anthelmitic and antimicrobial. Butea monosperma (Fabaceae family) locally known as Palash (Dhak) if given for 3 consecutive days acts as an antifertility agent for which it is traditionally used since time immemorial. The objective of present study was to search the effect of Butea monosperma seeds on the ovary of mice. Observations in the present study were massive degeneration of ova in almost all the follicles, irrespective of the stage of their development. The ova from treated animals showed different stages of necrotic process. Moreover, the arrangement of follicular cells was also disturbed. The Palash seeds in the form of powder administered orally showed notable changes in ovaries. Ovaries studied histologically showed most of the follicle in immature state with undefined nucleus and nucleoli in the ovum. Others showed degenerative changes in the ovum. It was conspicuous to find that almost all follicles including graafian follicles of treated ovaries were undergoing

Book of Abstracts 98 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine degenerative changes simultaneously. The rate of apoptosis in the granulosa cells when studied was found increased in treated cases as compared with control. The study suggests that the disintegration of ova in the ovaries is a specific effect of Butea monosperma seeds administration.

PA21 101. A Clinical Evaluation Of Anti Osteoporotic Activity Of Asthi Samharaka (Cissus Quadrangularis) In Post Menopausal Women Dipti Rekha Sarma, Jyotirmoy Sarmah

Purpose: Osteoporosis is a chronic disease with increasing incidence that predominantly occurs in female population specially after menopause. The mechanism of Bone resorption and reformation slows down after menopause due to lack of estrogen. The aim of the present study is to evaluate the clinical efficacy of the Cissus quadrangularis on different manifestations of osteoporosis in post menopausal females. Methodology: 30 post menopausal female patients with the clinical features of osteoporosis were selected from OPD and IPD of Pandu Govt hospital, guwahati. Trial therapy–250 mg of the stem extracts of Hadjod i.e Cissus quadrangularis has been used in this study in tablet form. Age: 45-60 years, Data collected by simple random sample technique, Subjective parameter pain, Stooped posture, Objective parameter Bone Mass Density (DEXA), Conventional X-ray, Duration 45 days (Follow up at the intervals of each 15 days and final assessment on 45th day) Results: The mean value of pain has been decreased from 2.26 to 1.33 with 41.15% reduction and stooped posture from 1.73 to 1.43 with 17.34% reduction which is statistically significant at P value <0.05 The mean BMD obtained before and after treatment is 1.76 and 1.10 respectively with 37.5%reduction which is statistically significant at p value <0.01. Conclusion: The study indicated efficacy of the plant clinically as indicated by the name of the plant - Asthisamharaka which means that which relieves diseases of bones.

PA22 104. Anti-Aflatoxin And Anti-Oxidant Activity Of Sahaj Vati: A Novel Herbomineral Formulation As Shelf Life Enhancer Shakti Bhushan, Kapil Deo Yadav, Anand Chaudhary

Purpose: The present research deals with aflatoxin inhibitory and antioxidant activity of a herbomineral formulation, sahaj vati regarding its chemical standardization. Methods: Formulation was prepared in two batches (batch I and II) by mixing shilajeet (thick exudates of the mountain during summer season), guggul (Commiphora mukul (stocks) hook.), haridra (Curcuma longa L) and chitrak (Plumbago zeylanica L) with levigation of Agnimantha kwatha (Premna mucronata L). Batch I was prepared by mixing shilajeet, guggul, haridra and chitrak in equal proportion (25% each by weight) while batch II comprised of shilajeet (44.7%), guggul (44.7%), haridra (4.8%) and chitrak (5.8%) by weight. Results: Sahaj vati II showed highest (96%) inhibition of aflatoxin production at concentration of 10000 μg/ml. Suddha guggul exhibited strong antioxidant activity showing lowest IC50 at concentration of 20.56 μg/ml. Conclusion: Based on these results, the newly formulated herbomineral formulation could be suggested for value addition of nutraceuticals by enhancing their shelf life against lipid per oxidation and aflatoxin contamination.

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PA23 110. Use Of Modern Diagnostic Techniques In Ayurvedic Diagnosis - An Analysis Through Case Studies Shyamasundaran K, Mallika KJ, Deepthi Viswaroopan

Purpose: To analyze the rationality of using modern investigative tools in Ayurvedic clinical practice using different clinical cases and the protocols followed in treating them. Methodology: The clinical cases are presented in three perspectives and each case will be analyzed on the investigations carried out and the treatments given. Results: The first case shows the relevance of cases been diagnosed with principles of Ayurveda, without getting carried away by investigation reports alone for diagnosis and treatment.The second case shows the usage of modern investigative techniques which helps to assess the condition during the process of treatment with Ayurvedic principles.The third case shows the usage of modern techniques that becomes inevitable in diagnosing a condition and which aids in Ayurvedic treatment. Conclusion: The rational use of investigation and understanding its applicability in Ayurveda considering Yukti as the prime tool in diagnosis and treatment is the key to successful management.This paper is intended to project the judicial use of modern techniques in Ayurvedic practice.

PA24 118. An Experimental Study To Evaluate The Cardioprotective Activity Of Ajeya Ghrita In Albino Rats Haris Cholakkal

Introduction: Cardiac toxicity damages the heart muscle causing arrhythmias developing into heart failure. Hr`dayavarana cikitsa is to protect hr`daya from the effect of visha. None of the drugs mentioned for hr`dayavarana has been studied.So the present study was selected to assess the cardioprotective effect of Ajeya ghr`ta in Isoprenaline induced cardiac damage in albino rats. Methodology: Cardioprotective activity in isoprenaline induced myocardial infarction was carried using Ajeya Ghritha at therapeutic dose.The biochemical parameters like SGOT, SGPT,CK-MB,CRPandALP, anti-oxidant parameters like catalase activity, glutathione peroxidase and lipid peroxides and Histopathological changes in the heart were analysed. Results: Serum SGOT, SGPT, CRP, and CKMB elevation was observed in isoprenaline administered group and a decrease in trial group. Isoprenaline administration reduced the total protein level while an increase in trial group. A significant increase of catalase activity was found in trial group. Reduction in lipid peroxides and infarct size was observed in trial group with relative weight gain. In histopathological examination injury to myocardium was found less severe in trial group. Discussion: Ajeya ghrita due to its ability to increase anti-oxidant parameters in the form of catalase activity and to reduce lipid peroxidation of myocardial cell membrane and its anti-oxidant activity responsible for inhibiting free radical generation prevent cell damage. Conclusion: The observed changes in infarct size and reduction in the degenerative changes observed in heart cytoarchitecture provide credible and strong evidence for the presence of significant cardio protective effect in the test formulation.

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PA25 120. Clinical Study On Cerebral Palsy And Its Management With Shastika Shali Pinda Sveda And Yoga Basti Rahul Ghuse, Virendra Kori, Rajgopala Shrikrishnan, Kalpana Patel

Introduction: Cerebral palsy is an umbrella term, covering a group of non-progressive but often changing motor impairment syndrome, Secondary to the lesions or anomalies of the brain, arising in early stage of the development. According to Ayurveda it can be correlated with Vata Vyadhi or Vata predominant condition following the methodology given by Acharya Charaka. Aim is to compare the efficacy of “Shashtika Shali Pinda Sweda’’ and “Yoga Basti” in the management of CP. Materials and methods: Total 12 patients of age group 6 month-10 years were registered and randomly divided into two groups. Group A (Shashtika Shali Pinda Sweda + Medhya Churna) and Group B (Yoga Basti + Medhya Churna).Assessment was done by standard assessment criteria for developmental milestones, muscle power and spasticity after 12 weeks of treatment with a follow-up of 12 weeks. The data obtained in clinical study was analysed by using student’s “t” test. Result: Both the groups have shown significant result (P<0.05) in most of the parameters but more eminent result was found in group A. No ADR found during clinical study. Conclusion: Selected Ayurvedic treatment modality was effective in relieving the signs and symptoms of Cerebral Palsy in the included sample of CP children.

PA26 125. Study And Optimization Of The Process Parameters Of Sulphur Purification Anjana CS, Jacob Titus M, Harisankar D, Rajeev VR

Sulphur commonly reffered as Gandhaka in Ayurveda literature. Sodhana of gandhaka is a vital process in converting naturally occurring gandhaka in to sodhitha gandhaka which is potent enough to be the part of aushadha kalpanas. Different types of sodhana process are explained by acharyas. Traditional sodhana processes are riddled with issues like low yield and exposure to toxic fumes due to uncontrollable temperature, laborious steps in purification process, Objective of the present study is to optimize the process of sulphur purification and to develop a test rig for gandhaka sodhana. The parameters and a design of the test rig were made after expert consultations and reviews. The fabrication of the test rig was done in private engineering firm. The optimization of the parameters was done through one factor at a time (OFAT) technique. The final fabricated product has three sections. A melting pot supported by a tripod stand,a collecting pot beneath and a temperature controller. The fabricated design is of 400 watts. At a coil temperature of 1300C, an input of 500g of gandhaka could be purified within 6 and half hour with zero wastage. XRD, ED- XRF, melting point, solubility in carbon di sulphide ash value analysis of the samples prepared by traditional method and newly fabricated method showed no significant difference. It implies that the newly fabricated machine produces sulphur which is potent enough for various aushadha kalpanas.

PA27 129. Preliminary Study Of The Role Of Ayurvedic Intervention In Type 1 Diabetes Mellitus (T1Dm) Amarnath Shukla, Chandravansi BK

Theme: Preclinical safety and efficacy of Ayurveda medicinal plants and formulations used in the management of

Book of Abstracts 101 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

Madhumeha (diabetes mellitus) Context: Type 1 diabetes mellitus (T1DM) is characterized by T cell-mediated selective destruction of insulin- producing β-cells. Despite modern medical management, T1DM is still associated with a mortality rate three to four times higher than that of the background population. To facilitate the development of therapies aimed at altering the type 1 diabetes disease process, an ayurvedic approach was convened to identify appropriate efficacy outcome after immune modulation measures in type 1 diabetes. Objective: To test safety and clinical efficacy of the ayurvedic immunomodulator in T1DM. Design: study design was a phase I/II randomized, controlled, open-label study Material and Methods: Twelve individuals with type 1 diabetes between the ages of 7.5 and 30 years and within 6 weeks of hospital discharge or diagnosis were recruited for participation. The diagnosis of diabetes was established by American Diabetes Association criteria and the diagnosis of type 1a diabetes was verified by the presence of anti-GAD65, anti-ICA512, and/or anti-insulin autoantibody. Interventions: Herbal compound contain four ayurvedic immunomodulator herbs. Study Outcome: The preliminary results of current study have clearly showed a statistically significant reduction biochemical markers and increase in C-peptide label at two weeks, 1 month and three months (P<0.001) in Trial group. Conclusion: study suggests that combination treatment with insulin therapy improves glycemic control, insulin sensitivity, beta cells function more effectively then insulin alone.

PA28 132. Management Of Chronic Stuffy Nose Due To Hypertrophy Of Inferior Turbinates By Ksharakarma, A Procedure Of Chemical Cautery In Ayurveda Jyotirmoy Sarmah, Hareswar Mahanta, Dipti Rekha Sarma

Nasal obstruction or stuffy nose, is one of the commonest complaints in ENT practice. If defects of nasal septum are excluded, dysfunction of the nasal turbinates constitute majority of the problem, mostly that of the inferior turbinates. Most of us experience some degree of turbinate dysfunction at some point in life, having said so,persistent dysfunction is also not uncommon. Short-term cases respond well to medical line of management which mainly constitute the use of decongestants, but their prolong use is not indicated. The other medicines too have only short-term benefits; but once the inferior turbinates undergo submucosal fibrosis, then they become incapable of decongestion with medicine and those chronic cases of nasal obstruction need to be managed by surgical therapies only. Many surgical procedures have been employed for turbinate reduction, but incidences of complications, recurrence etc. along with the cost-factor mean that still there is much to be achieved in the management of hypertrophied turbinates of nose. Ksharakarma is a popular procedure of chemical cautery in Ayurveda, which has been used for centuries as a minimal invasive procedure for reduction of enlarged tissues. Considering these, this study was conducted to manage nasal obstruction, Nasapratinaha in Ayurveda, due to hypertrophied inferior turbinates, by Ksharakarma. Apamarga Kshara has been prepared for this purpose; Kshara was applied over the anterior end of inferior turbinates. Results showed the mean of Size of inferior turbinates reducing from 3.4 mm to 1.5 mm with 55.88% mean reduction which was statistically significant at the P value <0.001.

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PA29 150. Role Of Śodhana In The Management Of Sidhmakuṣṭha: A Case Report Aramya A R

To report the importance of śodana in a patient diagnosed with sidhmakuṣṭha for 18 years and to discuss the need for routine śodana. There are numerous references in the classical texts on routine śodana measures required in management of skin diseases. The patient aged 67 years presented with raised thick scaly skin lesions all over the body, especially at the trunk and limbs with chronic itching, pain, burning sensation and occasional oozing. The patient was used to irregular food pattern, bowel habits and sleep for many years. The patient was diagnosed with sidhmakuṣṭha (skin affliction with lesions resembling alābu (bottle gourd) flower) with tridoṣa predominance and was managed at out-patient department with occasional in-patient treatments. To reduce the kupita doṣa (aggravated doṣa ), vamana was done after snehapāna followed by vasti. For two consecutive years that followed, routine virecana was done after snehapāna. After vamana, the scaling and the presented symptoms reduced and normal skin appeared. Though the medication was continued, there was recurrence of symptoms again which was successfully managed with further snehapana followed by virecana. This was routinely required to keep the disease on check. Thus need for routine śodana is required to successfully manage sidhmakuṣṭha. Though kupita doṣa was cleared, the līna doṣa(concealed and opportunistic doṣa) remained dormant. At present, the patient has minimal scales with normalized skin. This case substantiates classical understanding on management of skin problems.

PA30 155. Case Report On The Ayurvedic Management Of Endometriotic Cyst Of Ovary Deepika Singh and Asokan Vasudevan

Rationale for this case report: Many women with unexplained infertility may have endometriosis having prevalence of 25-40% with recurrence rate of 20-40% within five years following conservative surgery. This case report discusses the successful management of Endometriotic cysts of ovary through Ayurveda. Presenting concerns: Married woman aged 30 years anxious to conceive since six years with associated complaints of menorrhagia visited the OPD of Prasuti Tantra and Stree Roga at Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan in 2016. Past history revealed severe endometriosis with bilateral chocolate cyst (2*2cm in right and 3*2cm in left ovary) for which she underwent laparoscopic aspiration of the cysts and adhenolysis 3 years back. Follow up after 2 month showed complete remission of symptoms with anteverted uterus without sonological evidence of cystic ovaries. 2 years following surgery, USG revealed retroverted uterus with recurrence of bilateral chocolate cyst of increased size (5*4cm in right and 4*3cm in left ovary). Interventions: Snehapanottara Shodhana (Virechana) was given with Trivrut lehya and Draksha Kashaya followed by Shamana chikitsa with Kaishora Guggulu, Patrangasava and Panchatiktakaguggulu Ghrita. Outcomes: The patient responded well to Ayurvedic treatment alongwith regularized menstrual cycle in the course of 8 months. Subsequent USG scan revealed anteverted uterus of septate variety with simple cysts in right ovary (3*2.1cm and 1.7*1.5cm) with normal size and echo texture of left ovary without noticeable adhesion in pelvis. Main lesson(s) from this case report: This case study reports the reduction of symptoms and recurrence of the disease without any known adverse reactions on menstrual physiology and female fertility.

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PA31 159. Physicochemical Analysis Of Jalateertha Prajakta Kulkarni

Purpose: Scientific evaluation of Jala Theertha on the basis of its physico-chemical analysis. This is a one type of Samskara on Jala (water) by addition (cold diffusion) of tulasi leaves (occimum sanctum), Karpura (Cinnamomum Camphora), Ela (Eletteria Cardaniomum)and lavanga (Syzygium aromaticum)JalaTheertha protects from accidental and unnatural death and prevents from all kinds of diseases (ref. Hari-Bhakti-Vilas Gautamiya Tantra) and strong spiritual belief behind in it. So, analytical study should be done for safety and qualitative purposes. Method: Jalal theertha was collected from Temple of Lord Balaji, Aurangabad. Physico-chemical analysis of the Jala Theertha was carred out in the Dr. Sabnis's Jeevanrekha Analytical services, Aurangabad. Physico-chemical parameter Jala Theertha was subjected to an examination of physic-chemical parameters like Specific gravity, pH, Clarity, Turbidity, Refractive index, Total microbial count. Result : Physico-chemical analysis of Sample-Jala Theertha Clear colorless solution, Specific gravity (g/cc), 1.001, pH 6.9, Clarity - Clear solution, Turbidity - 1.7 NTU Refractive Index 1.790, Total microbial count, Not more than 300CFU Discussion: Description of sample was clear colorless solution shows the proper diffusion of substances into water. Specific gravity of sample was 1.001 g/cc. it is greater than 1 and water too. It indicates more productivity. pH conventionally represent acidity and alkanity. As we know nearby 7 is quality parameter, sample has 6.9 shows more qualitative index. Clarity of sample was clear solution, so it indicates proper dissolution of substances into Jala/ Water. Turbidity 1.7 indicates presence suspended particle into Jala Theertha. Refractive index of plain water is 1.33 but sample has refractive index 1.790 NTU which shoes presence of suspended particles in it. Total microbial count of sample was not more than 300CFU that indicates bactericidal activity. All the tests were performed as per API (Ayurvedic Pharmacopoeia of India) guideline.

PA32 163. In-Silico Analysis Of The Drug Sahadevῑ (Cyanthillium Cinereum (L.) H.Rob.) In Breast Cancer Shruthi Roy, Madhu KP

Purpose: To evaluate the anti-cancer activity and understand the probable mode of action of a single drug used in Ᾱyurveda cancer therapy Methods: Phytochemicals of Sahadevi (Cyanthillium cinereum (L.) H.Rob.) will be retrieved from database and molecular docking evaluation of the same with specific targets involved in the breast cancer pathways would be carried out in Schrodinger suite software. Discussion: Sahadevi (Cyanthillium cinereum (L.) H.Rob.) is a drug which has been used by Kottakkal Aryavaidyasala as single drug extract or in formulations for several years for cancer therapy especially in breast cancer. Clinical observations made there also suggest that it seems to limit the recurrence of breast cancer. Previous studies already point towards a general anti-cancer potential of the drug although its specific action on breast cancer needs investigation. It is also the need of the hour to inquire into the mode of action of such potential drugs as they can throw light on how such drugs act on body & specific pathologies. This study will augur such an effort.

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PA33 165 . A Success Story Of Management Of Hypothyroidism With Vamana Karma - A Case Study Sangeeta Sharma, Gopesh Mangal

Rationale for this case report: Hypothyroidism is one of the most common functional disorder of thyroid gland and is a very commonly encountered problem in clinical practice. The prevalence of hypothyroidism in the developed world is about 4-5% and the prevalence of subclinical hypothyroidism in the developed world is about 4-15%.This case study gives a description of successful management of a patient suffering with chronic Hypothyroidism with all the symptoms and highly raised TSH value. Presenting concerns: In this case study, a female patient of age 33 yrs visited Panchkarma OPD of NIA with registration no 14510032017. Patient presented with complaints of complete hair loss, joint pains, puffiness of face and eyelids, dry and coarse skin, constipation, weakness, lethargy, fatigue since 2yrs. Patient is suffering from Hypothyroidism since 8 yrs. Her TSH was 95.89 Uiu/Ml as on 8/3/2017. Interventions: Looking into the chronicity of the disease ,Vamana Karma was planned for the patient. As the symptoms were giving a complete picture of Hypothyroidism along with the investigation report, Vamana as a shodhana procedure was planned. Outcomes: Patient had very good relief in the symptoms after Vamana Karma. After the procedure the TSH was 10.03 Uiu/mL dated 27/3/2017,which is a remarkable change in laboratory investigations. Main Lesson(s) from the case report: This case study reveals that Vamana Karma can be a better line of management in chronic case of Hypothyrodism and further studies should be planned on large scale to establish the facts.

PA34 167. Antioxidative mode of action of Bacopa monnieri (predominantly bacosides) in preventing the neuronal cell from oxidative damage Baidyanath Mishra, Sujan Ganapathy, Sujata Mishra

Herbal medicine which is an integral part of the conventional and traditional medicinal forms is gaining wide importance of-late both in the western as well as developing countries owing to their efficacy and safety over their allopathic counterparts. Brahmi (Bacopa Monniera (L.), which is referred to as neuropsycotropic herb, has been used in Ayurveda since many centuries to address various neronal disorders and for enhancing memory, alertness and intellect. The Brahmi plant, extract and isolated bacosides (the major active principles) have been extensively investigated in several research laboratories for their biological activities, especially for their neuropharmacological actions. The antioxidant activity of Bacopa monnieri (BM) has been reported . Recently, a methanol extract of BM consisting of bacosides was found to provide effective protection against H2O2-UVphotolysis induced cleavage of DNA in human fibroblast. The extract exhibited dose-dependent free radical scavenging and suppressed the formation of linear DNA and induced a partial recovery of super coiled DNA. Similarly, BM significantly reduced oxidation and DNA damage in a dose-dependent manner in cultured rat astrocytes induced by a nitric oxide donor. BM helps in coping with combined hypoxic, hypothermic and immobilization stress that could lead to onslaught of 'free radicals'. The results also indicated that this extract exhibits interesting antioxidant properties, expressed by its capacity to scavenge superoxide anion and hydroxyl radical, and to reduce H2O2 -induced cytotoxicity and DNA damage in human fibroblast cells.

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PA35 170. Screening Of Anticancer Activity And Immunomodulatory Effect Of Shataputi Abhrak Bhasma Yogesh Tamhankar

Purpose: According to WHO, Cancer is the second leading cause of death globally in spite of available treatment modalities. Holistic approach of Ayurveda, concepts and preparations of Rasashastra need to be evaluated on today’s lifestyle disorders like Cancer. Shataputi Abhrak Bhasma, one of the drugs of Rasashastra, being Rasayan and Ayurveda’s nanomedicine, an attempt was made to screen its in-vitro Anticancer activity. Review of current literature indicates correlation of activity of Rasayanas with Immunomodulation. In view of this correlation, Shataputi Abhrak Bhasma was subjected to in-vitro assessment of Immunomodulatory effect. Objectives: To screen in-vitro Anticancer activity of Abhrak Bhasma at various stages of Putas (20,50,100). To evaluate in-vitro Immunomodulatory effect of Shataputi Abhrak Bhasma. Materials and Methods Shataputi Abhrak Bhasma, at various stages of preparation was subjected to in-vitro Anticancer activity using SRB assay on three Cancer cell lines (LungHOP62, LeukemiaU937, ProstateDU145) at ACTREC, Navi Mumbai. Shataputi Abhrak Bhasma was also subjected to in-vitro assessment of its Immunomodulatory effect using Nitroblue Tetrazolium assay, at ICT, Mumbai. Results and Conclusion: Abhrak Bhasma showed concentration dependent positive invitro anticancer activity on all three cell lines with highly significant activity of Shataputi Abhrak Bhasma on Prostate Cancer cell lines which was almost equivalent to positive control drug Adriamycin. Shataputi Abhrak Bhasma stimulated Leucocytes in concentration dependent manner. 5% and 10 % solutions of Shataputi Abhrak Bhasma stimulated 93% and 93.5% leucocytes respectively, which is an indicator of highly significant phagocytic activity. Thus, Shataputi Abhrak Bhasma showed positive Immunomodulatory effect in concentration dependent manner.

PA36 179. An Ayurveda Approach To The Management Of Trigeminal Neuralgia - A Case Report Ajisha DH, Prathibha CK, Anandaraman PV

Introduction: Trigeminal Neuralgia (TN) is characterized by excruciating paroxysms of pain in the lips, gums, cheeks or chin. Another feature is the presence of trigger zones, typically on the face, lips or tongue that provokes attacks with excruciating pain. TN is relatively common with an estimated annual incidence of 4.5 per 100000 individuals. Allopathic management of TN includes analgesics, anti convulsant, anti depressant medications. This will provide only temporary relief. After surgery Pain will be resolved but facial numbness will persist. Case Presentation: A 53 year old woman a pre diagnosed case of TN complained of severe pain over left part of head, chin and jaws associated with difficulty in opening mouth and chewing by the right side since 4 years. Management and Outcome: As such there is no direct correlation of disease in Ayurveda. Analysis of Dosha involved based on symptomatology found that, vitiation of predominantly Kapha along with Vata. Patient was managed in the outpatient department of school of Ayurveda, Amrita University, with internal medications and Prathimarsha Nasyam (nasal instillation-daily). Associated complaints occurred during the treatment were managed symptomatically. Outcomes were measured based on the relief of symptoms presented at the baseline and found clinically significant. Even after the follow up of up to 8 months no recurrence was observed. Discussion: Kapha Vatahara treatments were adopted mainly focusing Kapha. At time exacerbations of Pitta was also observed which was managed symptomatically. With a thorough understanding of Dosha involved we can manage the complex conditions like Trigeminal neuralgia.

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PA37 181. In-Silico And In- Vitro Study To Understand The Molecular Mechanism Of Emetic Action Of Identified Phytochemical Compounds In Madanaphala Medicinal Plant (Randia Dumetorum) Mediated By 5Ht3 And Nk1 Receptors’’ – A Proposal Reshma Ramakrishnan, Prathibha CK, Anandaraman PV

Introduction: In-silico studies speed the rate of discovery while reducing the need for expensive lab works and clinical trials. They are used to understand the receptor interactions with its drug/ or drug like molecules for its mechanism of action. Madanaphala is the best and safe emetic drug available for therapeutically induced emesis. It has been proved for its pharmacological activities but no where the active compound responsible for the emetic action of Madana phala is mentioned. So the aim of the study is to identify the active compounds in madanphala seeds mediating emetic action on binding towards 5HT3 and NK1 receptors. Research question: Whether 5HT3 and NK1 receptors are influenced by the emetic action of Madanaphala (Randia dumetorum) [An In-silico evaluation]? Which Active compound in Madanaphala is responsible for Emetic action mediated through 5HT3 and NK1 receptors (In-silico evaluation)? Methods: Study is planned in two phases a. Analytical study - i. Physicochemical evaluation (Qualitative Evaluation, Quantitative Evaluation, TLC, HPTLC & LC-MS) of various parts of Madanaphala in different forms. b. Molecular Docking study i. 9 pre identified compounds of Madanaphala are proposed for molecular docking studies with 5 HT3 and NK1 receptors. Outcome measures: Based on the results of Physicochemical study major/ active compounds will be identified and tested for its binding towards the active site of the 5HT3 and NK1 receptors. Based on the results of In Silico Study we are trying to explain the mechanism of action of the Madanaphala as an emetic drug.

PA38 182. Development Of A Portable, Cost Effective, And Efficient Shirodhara Instrument With Diverse Technologies Kadambari KB, Prathibha CK, Anandaraman PV

Alcoholic hepatitis is an intermediate stage in the spectrum of fatty liver disease, which range from benign steatosis to fatal cirrhosis. 10% of patients with steatohepatitis progress to cirrhosis over a time. The present case is of a 29 years old female suffered with chronic alcoholic hepatitis complicated with ascites. The patient was presented with symptoms of severe weakness, decreased appetite, pain in right hypochondrium, mild fever, breathlessness, vomiting, constipation, lower extremities oedema, severe icterus and increased abdominal girth. Abdominal ultrasound revealed hepatomegaly with diffuse fatty infiltration and possibility of liver parenchymal disease. Pseudocysts formation with mild atrophy of pancreas, mild splenomegaly. According to ayurvedic analysis, there was involvement of all the Doṣas with dominance of Pitta and Vāta. Āyurveda describes such condition as madātyaya. The patient was treated with Vardhamāna Pippalī, Katukī cūrṇa, Punarnavādi Kvātha, Bhṛṅgarāja cūrṇa, Ārogyavardhinī rasa, mixed powder of Bhūmyāmalakī, Śarpuṅkhā and Śveta Parpatī. Daśāṅga lepa is applied on abdomen to release abdominal discomfort. She was supplemented human albumin twice during the period of 60 days as an inpatient. Frusemide 40mg which she was taking before coming to us continued for one month and then stopped seeing good urine output and reduction in abdominal girth. After the treatment there was significant improvement in the condition of patient bringing severity from Child-Pugh stage C to stage A along with improvement in sign and symptoms. In laboratory findings total bilirubin level decreased from 25mg/dl to 2.6mg/ dl. Presently patient is in follow up as outpatient.

Book of Abstracts 107 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA39 184. An Ayurvedic Management Protocol In Generalized Anxiety Disorder- A Case Study Chandni Pillai C, Mahesh Kundagol C, James Chacko, Devipriya Soman

Generalized Anxiety Disorder (GAD) is a prevalent and disabling disease characterized by excessive worry about a variety of everyday problems for at least 6 months. Based on the clinical presentation, GAD shows more resemblance with Udvega Avastha of Manas(excited state of mind) which is one among the Poorvaroopas of Unmada. It is caused by vitiated Rajas (mano dosha) and Vata-Pitta (sareerika Dosha) kopa. Treatment for such a condition include Snehapana (intake of medicated ghee), Virechana (purgation), Nasya (nasal administration) and Bahyaprayoga like Abhyanga. Virechana brings about sodhana, both at the physical and psychic level. Nasya helps in sirasudhi, i.e. seat of mind. Abhyanga reduces the somatic symptoms . The present case is about a 26 year old female who was diagnosed as GAD, as per ICD 10 F41.1 with a score of 21 on HAM-A scale , managed using Ayurvedic principles. The patient was subjected to Deepana Pachana followed by Snehapana with Panchagavya Gritha for 5 days. Purgation with Trivrit choorna was done on 3rd day after Senahapana .After 3 days of Samsarjana karma (specific diet pattern), Abhyanga with Ksheerabala taila and Nasya with fresh juice of Sankhapuspi(Convolvulus pluricaulis), was done for next 5 days. Saraswathatarista was given as internal medication . At the end of 4 weeks, re-assessment was done using HAM-A Scale and the score reduced to 16. This study shows the case of GAD may be successfully managed Ayurvedic treatment.

PA40 185. Reduction In Score Of DAS 28 In Rheumatoid Arthritis (Ra) After An Ayurvedic Management – A Case Report Aswathi Rajan VK, Devipriya Soman, Mahesh Kundagol C, James Chacko

Rationale for this case report: This case report discusses the application of Ayurvedic principles showed excellent results in RA. Based on the clinical presentation, RA shows more resemblance with Amavata in Ayurvedic classics. Langhana (depleting therapy), Sodhana (bio-purification) and samana (pacification) treatments of Amavata were adopted as the line of management. Presentating concerns: A 32 years old female, visited our centre on 18th May 2017 for the complaints of Rheumatoid Arthritis and General fatigue. She had these complaints since February 2009. Presently there was involvement of knee, wrist, ankle and small joints of fingers. She has severe unbearable pain, every day. The joints were swollen, with redness and stiffness and diagnosed on the basis of ACR-EULAR 2010 criteria for RA. Interventions: The pain was under control as she was on immunosuppressant drugs and high doses of pain relievers for the past 2- 3 years. At this point, Ayurvedic treatment was started and she was administered Snehapana (intake of medicated ghee) followed by Virechana (medicated purgation as bio-purification), Upanaha Sweda (poultice) and internal medications and the patient responded positively without conventional managements. Outcomes: The patient responded well to Ayurvedic treatment and significant reduction in ESR and CRP level and other symptoms within 21 days. Main lesson(s) from this case report: This case study suggests that Ayurveda is a potential alternative to conventional interventions in the management of rheumatoid arthritis.

Book of Abstracts 108 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA41 186. Pre And Post Test Study To Evaluate The Effect Of Jatiphala Ksheerapaka In The Management Of Insomnia Susmi PS, Pratibha CK

Background: Good sleep is best indicator of good health .It is described as one among traya upastambhas in ayurveda. Insomnia has symptoms like difficulty in initiating sleep or maintaining sleep, waking up too early and unable to sleep again, waking up with feeling of lassitude etc. In modern science ,treatment of insomnia includes prescribing sleeping pills ,anti-depressants ,anti-histamines etc and their long term use causes many side-effects like daytime drowsiness ,changes in appetite ,dizziness ,weight gain etc.so,it is necessary to find out an alternative method to manage insomnia .Jatiphala being a toxic drug acts as sedative when given in small dose .Based on this principle, a study was conducted using Jatiphala ksheerapaka Aim: To evaluate effect of Jatiphala ksheerapaka in insomnia Participants: Ten patients fulfilling diagnostic criteria (Regensberg scale) and those suffering from both primary and secondary insomnia were included in the study. Methodology: All patients were given with half glass of Jatiphala ksheerapaka at bedtime continuously for 14 days.Factors like Sleep initiation time ,sleep disturbance ,early awakening etc were assessed before and after the treatment. Follow up was further done after 30 days and changes were recorded. Significant reduction were noticed in Insomnia and associated symptoms which stood as constant even after 30 days. Results: Paired-T test was used and the study concludes that jatiphala is clinically and statistically significant drug in managing insomnia.

PA42 187. Reduction In Score On Womac Scale In Knee Osteo Arthritis After An Ayurvedic Treatment Protocol - A Case Report Anjana S, Krishna Kumar K, James Chacko, Devipriya Soman

Rationale for this case report: The present day management of Knee Osteoarthritis involves usage of Analgesics, corticosteroid ,NSAIDS,etc which are having possible side effects like stomach upset ,stomach ulcer ,constipation, skin rash etc . Clinically Sandhigata vata is similar to OA .Hereby with all clinical experiences am trying to prove kneeOA can be treated without side effects in Ayurveda. Presenting concerns: A 60 year old lady was admitted for treatment of Kneeosteoarthritis which fulfilled ACR criteria. WOMAC scale revealed score of pain (12),stiffness(7), Functional Limitation(50) and X-ray revealed presence of osteophytes ,reduction in joint space . Intervention: Based on prior clinical experience Upanahasweda was used. She was administered Janu pichu and Mahasalvanasweda as external treatment and internally Rasnasaptakamkashayam(50mlbd) and yogarajaguggulu(2bd) for 14 days. Outcomes: At the end of 14 day reassessment was done using WOMAC scale and the score reduced to pain (6),stiffness(4) Functional Limitation (35). Hence Mahasalvanasweda ,Janupichu along with internal medicines was found effective in reducing the symptoms of OA on WOMAC scale within a span of 14days. Main lesson(s) from this case report:This symptoms reduced within first 7days without using painkillers. Its the need of hour to evaluate which Knee OAs are setting beneficial through this protocol.

Book of Abstracts 109 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA43 189. Pre And Post Test Clinical Study To Assess The Efficacy Of Tila Rasayana In Osteoporosis– A Proposal Deepa JG, Anandaraman PV, Prathibha CK

Introduction:Osteoporosis is a disease prevalent in India, characterised by decrease in the bone density and leads to fracture otherwise affect the quality of life of people.The presently available treatment options should be taken for a longer duration.AsthiKshaya explained in Ayurvedic classics can be compared with Osteoporosis and its treatment is VataharaChikitsa. Tila is best vatahara drug.Tila Rasayana explained in Ayurveda is adviced for the health of Danta which is Upadhathu of Asthi and are directly proportional to each other. Studies shows that Sesamumindicumstimulate osteoblast differentiation.The objective of the study is to find the effect of tila rasayana in improving the bone mineral density and quality of life of Osteoporotic patients. Method of study:In this study 20 patients with BMD t-score of more than -2.5 in pDEXA scan,fulfilling the inclusion criteria will be selected from the OP department of School of Ayurveda,Amrita University. During the first fortnight Patients will be given with Deepana Pachana, SodhanangaSnehapana and Virechana (Therapeutic purgation). After Virechana Tila Rasayana in the prescribed form and method will be administered for 30 days. Outcome measures:The patients will be assessed with pDEXA scan for BMD, and Quality of Life Assessment, bone biomarker blood test including Serum Calcium and TALPbefore and after treatment.Hence this study is aimed to find a safe, cheap and effective treatment and to reduce the duration of medication in osteoporosis.

PA44 191. An Invitro Study To Evaluate The Antibacterial Property Of Haridradi Varti Dhuma (Medicated Smoke) Against Respiratory Pathogens Rakhi Rajeev R, Anandaraman PV, Parameswaran Namboothiri K

Introduction: Respiratory diseases are associated with one or more of the respiratory pathogens like Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumonia and these microbial agents probably interfere with immunological pathways and itrequires continuous medical care. According to Ayurveda these conditions can be brought under Swasa or Kasaroga. In Ayurveda drug inhalation through Nasal route (Dhumapana -herbal smoke) are mentioned for respiratory conditions to get immediate effects. The Invitro study is intended to evaluate the antibacterial activity of Haridradivartidhuma(most of the drugs in HaridradiVarti are proven as antibacterial) against the respiratory pathogens like Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumonia. Research Question: Is there any antibacterial activity for the smoke ofHaridradiDhumavarti against the selected respiratory pathogens Methods: The Haridradi Varti will be prepared withHaridra,Patra, etc.drugs.Varti will be burnt and thus produced smoke will be introduced into closed sterile chambers. Petri dish containing the colony of bacteria will be exposed to this herbal smoke. The temperature and pressure inside the chamber will be monitored. Excess of air will be letting out through the outlet valve, provided in the chamber. The procedure should be done morning and evening hours and bacterial count will be noted after every set of exposure. Outcome Measures: Out comes will be measured based on the bacterial count after every set of exposure of Smoke to establish the Antibacterial property of HaridradivartiDhuma.

Book of Abstracts 110 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA45 206. A Comparative Study On The Outcome Of Surgical Procedure Of Partial Fistulectomy With Ksharasutra Application And Simple Ksharasutra Application In Fistula In Ano On The Basis Of Objective Parametrs Santosh Verma, Bandana Singh and M.Bhaskar Rao

Objective: Anal fistula is a condition which has been recognized as a difficult surgical disease in all the ancient and modern medical sciences of the world. The approach to the treatment for a single disease is only suggestive of the fact that none of these methods is satisfactory. 'Ksharasutra' is being used successfully in the management of anal fistula. But Ksharasutra application takes longer duration of therapy and hospitalization and and patient suffer for longer duration with mild constant pain and discharge. To overcome all these problems, partial fistulectomy with 'Ksharsutra' and only Ksharsutra application has been studied in this paper with a statistical evaluation. The present clinical trial is designed as single blind randomized study over the patient suffering from Bhagandara (Fistula in ano). The clinical study was carried out on 40 patients in two different groups, each comprises of 20 diagnosed cases of Bhagandara (Fistula in Ano). Group-A: 20 cases was treated by Partial fistulectomy with Ksharasutra application. Group-B: 20 cases was treated by simple Ksharasutra application In this study effect of both types management in fistula in ano. (GROUP-A, AND GROUP-B,) was assessed on the basis of changes observed after the treatment in objective parameters. parameter the average U.C.T, C.H.T, P.R.D of the individual groups was done. On analysis the data statistically it was found that Group-A showed better results than Group-B. and detailed description will be explored, in the form of paper presentation

PA46 207. Cittodvega: Emergence Of Disease Nomenclature From A Possible Scribal Error Shivateja Jagarlamudi, Sushma

Objective: To analyze the terminologies of udvega and cittodvega in the context of Generalised Anxiety Disorder. Background: Generalized anxiety disorder has been co-related with the term cittodvega by the ayurvedic physicians in the modern times. The word cittodvega has been derived from a single possible occurrence in carakasamhita. On a closer look, it appears that the origin of this term can be traced to a scribal error. Method: The major classical texts were reviewed to list all occurrences of the terms udvega and cittodvega. There are in total 16 references to the word udvega in the samhitas. A careful study of the commentaries and the etymological derivatives of the word was done. Results: On the basis of the analysis of this data, it was found that there is a variant to the reading cittodvega. Some manuscripts read chinta and udvega instead of cittodvega. Considering the fact that the word udvega itself indicates anxiety, the term cittodvega appears to be superfluous. Conclusion: An interpretation of the word udvega and its meaning indicates that it co-relates with Generalized anxiety disorder. It is thus recommended that the word udvega may be used instead of cittodvega. Application: This study reveals that critical edition of the classical texts is important for proper interpretation of technical terminologies.

Book of Abstracts 111 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA47 208. Post Partum Depression: Prevention By Diet And Psychotherapy Vandana Vasudevan K, Hemavathi

Introduction: Ayurveda, the system of traditional medicine holds that dietary regimen and psychotherapy, corresponding to the pathyahara and satvavajaya chikitsa, as the basis of treating psychological diseases. The classical references regarding Sutika rogas like pravahika, asrigdara ,sula which can continue as bhrama, unmada, correlating to postpartum depression, with an estimated prevalence of 13% ,can also be managed with ayurvedic protocol. Methods: The literary research was done through published journals, research articles and classical references in relation to psychological disorders in post natal woman associated with coeliac disease. Result: This idea has recently found support in post partum depression associated with coeliac disease ,in which the intestinal cilia is unable to absorb vitamins and nutrients gradually leading to hallucinations and post partum woman tends to kill her own child. Discussion: This paper discusses a possible scientific approach in understanding the ayurvedic hypothesis in terms of prevention of coeliac disease caused by intake of food with gluten (wheat protein) ,which causes malabsorbtion of vitamins ,and leading to psychological symptoms during post partum period. We conclude that by following the pathyaharas after delivery and with different methods of satvavajaya chikitsa , can prevent post partum depression associated with coeliac disease.

PA48 210. Studying The Effects Of Suryanamaskar Using Signal Processing Techniques Eeshan Phatak, Sumant Gaopande, Abhishek Patil, Yudhishthir Deshpande, Jayshree Ghorpade-Aher, Kalyani Deopujari, Aniruddha Joshi

Purpose: Ancient wisdom of Yoga has potential to understand the essence of life and transform the lifestyle of an individual. Various evidence based research suggested that Suryanamaskar has a positive impact on the metabolism. Analyzing a nadi pattern is a good way to note the changes happening in metabolic functions. We have studied the nadi patterns using signal processing technique to understand the effects of Suryanamaskar. Methods: Nadi signals were recorded using Nadi Tarangini device through three pressure sensors at vata, pitta and kapha locations before and after Suryanamaskar sessions. The experiments were performed on 36 individuals (27 male, 9 female) of age group 18-23 years for 7 days. Signal analysis was done using various time and frequency domain signal processing features and morphology patterns (Percussion(P), Tidal(T), Valley(V), Dicrotic(D) pattern analogous to PQRST in electrocardiograph) in order to understand the changes in Nadi patterns before and after the Suryanamaskar sessions and also the changes throughout 7 days. Results: Visual and statistical analysis was performed on the extracted features. We found the substantial difference between the features and pulse patterns for different prakrutis. There were significant changes in the morphology patterns of the pulse. In particular the Valley point(V) has shifted after performing Suryanamaskar. The energy of the pulse beat showed prakruti dependent variations. Conclusion: The results found demonstrate and support the immediate and long term effects of Suryanamaskar on the individuals. This research can further be used to study the effects of Suryanamaskar on disease specific patients.

Book of Abstracts 112 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA49 214. Modification Of Milk Decoction (Ksheerapaka) Of Tribulus Terrestris Into Dehydrated Milk Powder – A Proposed Technology Integration Vineeth PK, Abhaya Kumar Mishra

Background: Milk decoction is a unique preparation told in Ayurveda.Eventhough proved to be effective,they are not widely prescribed and used owing to its difficulty in preparation,bulkiness and very short shelf life.Milk powders were developed and used as an alternative of raw milk in food industry but no modifications of milk decoction is available in the pharmaceutical industry till date. Objective: The objective of the study is to modify milk decoction of Tribulus terrestris into dehydrated milk powder and an invivo comparison of its efficacy on spermatogenesis and sperm parameters. Design:Phyto–chemical studies of Gokshura will be done to authenticate the raw drug and to identify its active ingredients.Ksheerapaka will be prepared according to classic references and standardized, followed by the preparation of dehydrated milk powder by four methods viz Spray drying, Vaccum drying, Drum drying and Freeze drying.The testis tissue and semen will be collected from 30 Adult Wistar male rats,allocated into six groups, vehicle control (n=5) and test groups (n=25), of 5 that received milk decoction and milk powders prepared by different methods for 20 consequent days. Outcomes: The changes occurring in each step of preparation of decoction, milk decoction and dehydrated milk powder will be studied using LC-MS.The milk powders will be compared analytically and studied for standards laid down by FSSAI .Weight of individual male testis, sperm count, viability, motility,Serum FSH, LH, Total testosterone hormone and Histopathological study will be compared.

PA50 220. Successful Management Of Khalithya (Hair Loss) With Ayurvedic Treatment – A Case Study Sarath S, Priya Sreekumar, Vimala KS, Priyalatha B and Raiby Paul P

Rationale for this case report: Hair loss is one of the most common problem faced by the current society, however when it becomes severe like alopecia or baldness medical intervention is mandatory. Nasya is highly recommended and equally effective in all jatrudwavikaras (diseases pertaining to the parts above shoulders). Modern medicine advocates the use of minoxidil, biotin etc for promotion of hair growth but treatments are very expensive and unsatisfactory. Presenting concerns: A patient with age 26 complaints with hairloss, was under allopathic treatment. He was physically fit with good body built. Interventions: Udwardhanam were done with triphala choorna and kulatha choornam for seven days, then marsha nasya was started with Anu tailam for seven days and Shadbindhu tailam for fourteen days. The procedure was done ones in a day for a total period of 21 days (nasyam). Internal medicines were also given. Analysis was determined by taking photography before and the treatment plan. Outcomes: Growth of hair and the thickness has been increased, so this study provides evidence that we can effectively manage hairloss with simple remedies like Nasya and Udhwardhana however this is a small scenario and in depth, research has to be done to analysis and understand similar clinical conditions with various presentations for offering better health care services to the patients.

Book of Abstracts 113 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA51 224. Evaluation Of In Vitro Melanogenesis Inhibition Activity Of Kadamba (Anthocephalus Cadamba Miq.) Siddhisha Kurve, Paras Golecha, Rupa Kadam

Purpose: Healthy appearance of skin mainly consists of a smooth texture and an even pigmentation. Normal skin color is imparted by pigment Melanin. Imbalance of Melanin production may lead to either hyper or hypo pigmentation. Hyper pigmentation is a condition characterized by excessive deposition of the pigment Melanin in the epidermal layer of skin. Long term or continued use of synthetic cosmetics can lead to untowards effects. Hence, there is a constant demand for newer and more efficacious skin pigmentation regulating agents in the field of bioactive cosmetics. Kadamba is stated as Varnya i.e. known to regulate skin pigmentation as per Acharya Vagbhata but remains comparatively underexplored. Method: In the current study, Anthocephalus cadamba Miq. has been screened for inhibition of melanogenesis, using a bio- chemical assay. As the enzyme tyrosinase plays a key role in the melanogenesis, anti tyrosinase activity of Kadamba was investigated. Results: Tyrosinase enzyme inhibition by the crude drug powder was examined at various concentrations ranging from 0.5mg/ml to 3 mg/ml. The IC50 value for enzyme inhibition was found to be 1.80 mg/mL ± 0.10. Conclusion: The results have shown that Anthocephalus cadamba miq. has potential to be used as an effective depigmenting bio active agent. Further studies need to be carried out in order to establish Kadamba as an alternative skin lightening and depigmenting agent.

PA52 228. Systematic Review On Administration Of Brahma Rasayana As An Adjuvant To Chemo And Radiation Therapy Meera S, Delvin Robin T , Vandana Rani M

Purpose: Chemo and radiation therapy although a significant component of Cancer therapy, needless to say has side effects. Thus there is a need to identify and develop therapies which reduces the disease progression and nullify the undesired effects of chemo and radiation therapy. The current review aims to explore the potential of Ayurveda in the area and summarize the evidence on usage of brahma rasayana as an adjuvant in chemo and radiation therapy. Methods : Pub Med and Scopus were systematically searched for studies published in English between January 1985 and April 2017. The efficacy of Brahma Rasayana is discussed on the basis of available data. Results : Brahma rasayana has been extensively studied for its antioxidant activity in in vitro and in vivo. Evidences support the protective association of Brahma rasayana in reducing metastatic spread. Reduced levels of liver antioxidant enzymes due to radiation were significantly elevated by treatment with Brahma Rasayana after radiation treatment. It accelerated recovery of hematopoietic system which was proved by a total rise in leukocytes. It also reduced the oxidative stress induced by cancer treatment Conclusions: Compelling evidence supports the administration of Brahma rasayana yet more controlled clinical trails need to be done and scientifically documented. Its impact on the quality of life of patients need to be analyzed to prove its multifold benefits. The review suggest that the integration of the treatment modalities can set a benchmark for future cancer treatments. The therapeutic efficacy of this simple cost effective treatment will serve as an adjuvant in chemo and radiation therapy.

Book of Abstracts 114 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA53 229. An Algorithm For The Ayurvedic Management Of Ankylosing Spondilitis – A Case Study Fasnath Arabi, Jithesh Madhavan

Ankylosing spondylitis(AS) belongs to a group of rheumatic diseases known as the spondyloarthropathies (SpA), which shows a strong association with the genetic marker HLA-B27. There is insidious, progressive involvement of spinal joints especially the sacroiliac joint. Inflammatory back pain and stiffness are prominent in the early stage of disease, whereas in chronic aggressive state, may produce severe pain and marked axial immobility or deformity. Various Panchakarma procedures and Ayurvedic drugs have been proved useful for these manifestations. Ayurvedic approach is directed towards alleviating the symptoms and to reduce severe disability. A 45 year old lady presented with AS, which was treated for 1 1/2 months with a combination of Panchakarma procedures and selected Ayurvedic drugs. The patient was diagnosed as Asthimajja gata Vata (saama stage) and was treated with Rookshana followed by Snehapana, abhyanga, ushmasweda and Virechana. Yogavasti with Erandamooladi nirooha yoga along with sahacharadi anuvasana and followed by samana drugs. Patient's condition was assessed before and after treatment with Validated disease-specific instruments for AS – Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Global Score (BAS-G), Bath Ankylosing Spondylitis Metrology Index (BASMI), Dougados Functional Index (DFI). Here a single case report of AS is presented in which there was considerable improvement after the therapy.

PA54 234. Successful Management Of Obesity With Ayurvedic Intervention - A Case Report Pramod S

Rationale for this case report: An estimated 300,000 deaths per year are due to the obesity epidemic. According to the National Institutes of Health, obesity and overweight together are the second leading cause of preventable death in the United States and causes major risk factor for cardiovascular diseases. A new study published in The Lancet Journal reveals that India ranked 3rd with obese people and based on data from the 2007 National Family Health Survey the state, Kerala ranked with 2nd highest percentage of people who are overweight and obese. This case report discusses the successful management with Ayurvedic treatment of a case diagnosed as obesity with economical and easily administrable methods in short duration. Presenting concerns: A 35year old moderately obese lady with increased body weight and consistently maintained at 95kg for past 7years was admitted at Amrita Ayurveda Hospital with increased appetite even after frequent intake of food and having negligible physical work. The features were suggestive of obesity and investigations reveals normal lipid profiles and also free from secondary obesity. Interventions: Ayurvedic treatment was started with a course of 15 days of both internal and external medications and the lady responded positively. Outcomes: The patient responded well to Ayurvedic treatment with remarkable results. The weight, BMI and anthropometry methodology confirms the above results. Main lesson(s) from this case report: This case study demonstrates the need for further study of case series to evaluate the outcomes of Ayurvedic interventions in obesity.

PA55 236. Crest Syndrome - A Case Report Rajalekshmi S

Rationale for this case report: Crest syndrome means limitted sclederma that is hardened skin with specific symptoms like Calcinosis,Raynauds phenomenon, Esophageal dismotility, Sclerodactly and Telengectasia which is a

Book of Abstracts 115 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine rare condition which have poor prognosis and has no known cure, the treatment focus on managing symptoms and preventing serious complications and improving quality of life. This case report discusses the sucessful management with ayurvedic management Presenting Concerns: A 47 year old women who is under thyroid medication for hyothyroidism and with complaints of gastric distress for more than 10 years came to our opd with presenting complaints as hyperkeratinised hyperpigmented lesions on both lower legs with non pitting edema and ulcerations for the last 5 months The features with ANA profile suggestive of crest syndrome. Intervention: For these Presenting complaints through ayurvedic management got symptomatic relief and quality of life get improved. For ulcerations advised surgery from a centre where the facility was available. Outcomes: The patient well responded to ayurvedic management and got symptomatic relief and quality of life got improved with 6 months course of treatment. Main lessons from this case report: Even though diseases where no known cure can be well managed through ayurveda treatment .This case study will be an evidence for this.

PA56 238. Definition, Classification, Descriptions And Management Of Pain In Classical Ayurvedic Literature: A Comprehensive Review Sujithra RM, Priya S, Vimala KS, Priyalatha B, Raiby Paul

Objective:To define and classify pain as well as list varied descriptions of pain highlighting varying approaches adopted in Ayurveda for management of pain in specific stages of different diseases. Background:Pain is defined as physical suffering or discomfort caused by illness or injury. Modern medicine classifies pain as Nociceptive, Neuropathic or Inflammatory based on underlying mechanism, mild, moderate or severe depending on severity and acute, chronic or acute on chronic based on duration. Pain management aims to either interfere with transmission of signals to brain (analgesics) or knock out the brain (anaesthetics). This approach works in management of acute pain, but not in chronic pain. In chronic pain, Ayurvedic treatment has reported to be effective. An attempt is being made here to understand the Ayurvedic understanding of pain and its management. Method: Aṣṭāṅgahṛdaya Nidāna Sthāna was searched and terms describing different types of pain were tabulated. Few treatment approaches were randomlt compiled from Cikitisa Sthāna of the same text. Result: Totally 226 terminologies describing different types of pain were documented in specific stages of various diseases in Nidāna Sthāna. Vāta is considered to be responsible for creating the sensation of pain, but pain can be triggered and modulated by many other factors. Treatments described in the Cikitsā Sthāna for pain management were found to vary in different stages and types of diseases, implying that Ayurveda aims to address factors underlying pain rather than a generalised symptomatic management. Conclusion: Ayurveda focuses on source of pain and treatment given depends on the causative factor that triggers pain rfather than just blocking signals that generate pain. Application: A thorough study of the Ayurvedic approach to understanding and dealing with pain can potentially help us to discover new approaches to manage chronic pain.

Book of Abstracts 116 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine

PA57 243. Swaramakshikabhasma And Its Pharmaceutically Modified Formulation Against Veerataraadigana Kashaya In Treatment Of Mutrasmari- A Comparative Clinical Study A Divya, Jai G

Background:Bhasmas, a unique preparation in Rasasastra, is now gaining wider acceptance in Ayurvedic therapeutics. A bhasma preparation indicated in Mutrakrcchra, with adjuvant suggestive of its effect in Asmari; a simple combination of Swarnamakshikabhasma along with Yavakshara, fitting well within the limits and scope of this study was selected as trial drug. Research Design: The study was proposed as comparative clinical trial with Veerataraadigana kashaya as control drug and combination of Swarnamakshikabhasma as trial drug. A second trial drug made by pharmaceutically modifying the trial drug with the control drug was included in the study to find the combined effect. Method: 45 patients satisfying the inclusion criteria were selected, randomly divided by lottery method into three groups– control group, trialgroup1 and trialgroup 2 and medicines were given accordingly. The patients were asked to report periodically for 3 weeks, after which re-assessment was done. The results were statistically analysed and compared. Findings: Trial drugs were effective in decreasing the size and number of calculi, and expelling calculi. Trial drugs showed better effectiveness than Veerataraadigana kashaya in the management of most subjective parameters and findings were substantiated by the effect seen in the objective parameters. Effect of trial drugs between themselves was almost equal regarding most parameters. Conclusion: Both trial drugs were effective in the management of mutrasmari. Both classical combination and pharmaceutically modified combination were having almost similar effects, but more beneficial in management of mutrasmari than the control drug.

PA58 249. Management Of Diabetic Foot Ulcers By The Integrated Treatment Of Ayurveda And A Course Of Antibiotics – A Case Report Shalini UA, Siddayya Aradhyamath, Pravini Valsalan

Rationale for this case report: Prameha is one among the major diseases, and prameha pidakas (diabetic carbuncles) are complications of prameha and they turns into dushta vranas if neglected. If not treated appropriately, foot infections can lead to septicemia, amputation and death. Infection in patients with diabetes are difficult to treat because these patients have impaired micro vascular circulation, which limits the access of phagocytic cells to the infected area and results in a poor concentration of antibiotics in the infected tissues. This case history demonstrate the adverse effects of diabetes on foot, and the collaborated treatment contribution to successful management and healing of the surgically debridement wound. So it was treated with jaloukavacharana (leech therapy), panchavalkala kashaya seka, shamanoushadhis, and course of antibiotics and anti diabetic drugs was given parallel. Now the patient is asymptomatic and wound healed completely. Presenting concerns: A 71 year old woman was under insulin for diabetic management since 6 years, she got admitted to JSS Ayurvedic Hospital, Mysore on july 2016 with history of amputation of right leg 4th toe 20days back, it was infected, oedematous, slough was present, infection was spreading to plantar surface and tendons were affected. The features were suggestive of dushta vrana(diabetic foot ulcer). Interventions: She was referred for one more surgery amputation till the ankle(ankle disarticulation) but the patient refused for amputation and Ayurvedic treatments were started and patient responded well. (4) Outcomes: The patient responded well to Ayurvedic treatment and recovered in the course of two months. Wound healed

Book of Abstracts 117 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine completely. Main lesson(s) from this case report: The patient is alive and symptoms free and leading normal routine life without deformity. This case history demonstrate the adverse effects of diabetes on foot, and the collaborated treatment contribution to successful management and healing of the surgically debridement wound and the need for further studies to evaluate the outcomes of Ayurvedic interventions in Diabetic foot ulcers.

PA59 252. Reduction In Size Of Thyroglossal Cyst After Application Of Leech- A Case Study Archana SR

Rationale for this case study: A congenital Thyroglossal cyst presented with palpable asymptomatic neck mass which moves upwards on swallowing or on protrusion of tongue associated with throat pain. If left untreated it may ruptures resulting Thyroglossal fistula. The only final Allopathic management possible was surgery, but may leads to post-surgical complications like loss of voice, hemorrhage etc. This case study reports effectiveness of leech therapy as an alternative to surgical removal of cyst. Presenting concerns: A 23 year old female felt a hard mass over the midline of neck since 2 years. It was painless and moves upwards on swallowing. Diagnosis: Thyroglossal cyst was diagnosed with USG along with thyroid profile and FNAC.The cystic lesion measures 11×7mm in above the hyoid bone. Thyroid profile and FNAC were in normal limits. Interventions: Ayurvedic treatment was started both internally and externally for 2 months but, patient did not respond to conservative Ayurveda treatment. So drastic cleansing measures were administered.Vamana was done after 6 months which didn't show any changes in the swelling. After 3 months two sitting of leech application was done with one month gap. Outcomes: After 3 months of raktamoshana (leech application) ,USG scan revealed that the size has reduced from 11×7mm to 4×3mm. Main lesson(s) from this case study: There was no consequences after leech application.

PA60 256. A Case Study On Effective Management Of Preeclampsia With Contempory Medicines Associated With Ayurveda Vidya Pillai

A leading cause of maternal & neonatal death worldwide is preeclampsia & hypertension. Preeclampsia is a syndrome that arises in pregnancy affecting 5% - 8% of all pregnancies. Hypertension may or may not preexisting . The identification of this entity & effective management plays an important role in the pregnancy outcome. Hypertensive disorders of pregnancy can be identified & effectively managed by yoga pranayama music along with allopathic systems of medicines. Yoga reduces the perceived stress ,anxiety and modulate stress response system. Asanas like Padmasana which can be done during pregnancy improves digestion by redirecting blood flow to abdominal region and applies pressure to the lower spine which relax the entire Nervous system .Siddhasana advisable during pregnancy is relaxing. Pranayama withdraws the sympathetic tone in the skeletal muscles , blood vessels leading to widespread vasodilatation thus decrease peripheral resistance and the diastolic blood pressure. A collaborative method of using traditional contempory & alternate medicine will reduce maternal and foetal complications and enhance quality of foetus in IUGR On the basis of this a case study is going to be presented Patient with k/c/o fatty liver ,BP undergone treatment for infertility and conceived. During gestational period she

Book of Abstracts 118 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine suffered from liver pathology , HTN and in last trimester she had Diabetics. In view of sensitivity of the patient contemporary medicines associated with Ayurvedictreatment to nourish the baby. Pranayama and music therapy was given. Ineviatabily patient has undergone LSCS at 37 weeks foetal outcome was good demanding little care as in normal babies.

PA61 259. Role Of Ksharasutra And Partial Fistulectomy In The Management Of Fistula In Ano– A Pilot Study Bijendra Shah, Tukaram Sambhaji Dudhamal

Ksharasutra is being practiced from ancient times to global era for management of fistula-in-ano. Fistula-in-ano is an abnormal hollow tract or cavity that is lined with granulation tissue and that connects a primary opening inside the anal canal to a secondary opening in the perianal skin; secondary track may be multiple and can extended from the same primary opening. Ksharsutra is an Ayurvedic medicated thread coated with herbal alkaline drugs that is Achyaranthus aspera, Euphorbia neurophelia and Curcuma longa. 'Ksharasutra therapy' has been described as a treatment of choice for the treatment of fistula-in-ano. METHOD: Five diagnosed cases of fistula in ano were taken from IPD of Surgery ward of IPGR&RA, Jamnagar. Under spinal anaesthesia partial Fistulectomy was done and applied the Ksharasutra thread in remaining fistulous track. Post procedure dressing was done with Neem (Azaridicha indica) oil (Medicated Ayurved oil) and ayurvedic laxative was prescribed. Ksharasutra thread was changed by every 7 days. The fistulous wound was healed and simultaneously fistulous tract was cut through with Ksharasutra. The procedure of the partial ficstulectomy and Ksharasutra application will be shown by video during presentation of paper in conference. RESULT: All five patients were cured early without complication and recurrence. The modified procedure minimize hospital stay, minimum sphincter injury, maintain integrity of sphincter, few recurrence rate (2%) and cost effective. During treatment period patient can start routine work within week. COUNCLUSION: This study manifests that Ksharasutra ligation in Partial Fistulectomy was found effective with very low recurrence and minimal injury.

PA62 287. A Single Case Study On Chronic Plaque Psoriasis In Terms Of Ekakushtha Kalpana Rao, Mythrey RC, Gajanana Hegde

Rationale: Psoriasis is a chronic disease that can have a significant effect on quality of life. Any approach to the treatment of this disease must be considered for the long term. Response to the treatment of psoriasis is not much appreciated, In spite of various treatment modalities adopted in the contemporary medicine, owing to its recurrent nature, Chronic plaque psoriasis still remains a challenge for the management. This case report discusses the successful management with Ayurvedic treatment and also had significant outcome. Presenting concerns: A 47yr old male patient diagnosed for psoriasis since 10 yrs, consulted and got admitted at Government ayurveda hospital, Mysuru, with the c/o itching, scaling, erythema and discharge. Interventions: Due to reoccurrence and increased severity he approached Ayurvedic system of medicine. At this point Ayurvedic treatment protocol for Ekakushta(~ psoriasis) was planned and managed accordingly which responded positively. Outcomes: At the end of 30 days of treatment involving shodhana (virechana) followed by shamanoushadhis and external medication resulted in significant improvement in the overall effect of therapy in terms of itching, scaling, erythema and thickness .PASI score was initially 59.9 before treatment, after virechana procedure it reduced to 29.4 and after 20 days of shamanaushadhi it reduced to 0.

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Main lesson: The patient is symptom free and recovered from the disease. This case study demonstrates the need for further studies to evaluate the outcomes of Ayurvedic interventions in Psoriasis for long term effectiveness/re occurrence.

PA63 293. Effect Of Ruksha Vasti On Reducing Renal Parameters In Chronic Glomerulonephritis: A Case Report Meera S, Vidyaprabha Pillai G

Glomerulonephritis is a condition that presents with persistent proteinuria, hypertension of insidious onset or as a late sequel to an acute episode. As a result there will be granular changes along with interstitial fibrosis and tubular damage of the glomeruli. Chronic glomerulonephritis is the third leading cause of chronic Kidney Diseases and it accounts for about one tenth of patients on dialysis. The conventional therapy includes administration of NSAIDS, antihypertensives, diuretics and steroids. A 24-year-old male, a diagnosed case of glomerulonephritis, presented with low back ache, haematuria , albuminuria +, raised serum creatinine and serum urea . He was on conventional management of glomerulonephritis ie, ca – channel blockers, multivitamin therapy, and urine alkaliser and loop diuretics. With the aim of bringing down serum creatinine, he was given ruksha vasthi with guluchyadi kashaya (300ml) and vaiswanara churna (30g) for 3 consecutive days . He was allowed to continue his medications while the vasthi was done. In an RFT evaluation just preceding the ruksha vasthi, the values were - serum creatinine 3.4mg/dl , serum urea 51mg/dl. After the procedure, RFT was again evaluated, which was recorded as: serum creatinine 3.1 mg/dl, serum urea 40 mg/dl.

PA64 294. Changes In Kirlianography Before And After An Ayurvedic Intervention:An Observational Study Hrishikesh Othaloor Krishnan, Soumya Saraswathi M, Raghavendra Udupa

Back ground: Understanding Marma by analyzing Prana/Life force/Aura by kirlianography. Objectives of the study: 1) To review the concept of Marma in CharakaSamhita.2)To review the treatments told for diseases arising out of Trimarmas.3) To critically review the ‘Trimarmeeya siddhi’ adhyaya for curative aspectsof Marmachikitsa.4) To evaluate the Life force-Prana (Aura) of a patient having Arditha before and after (7 days of thalapodichil) treatment by Kirlian photography Materials and methods: Upanahachurana was preapared at a GMP certified center by taking equal quantities of dried Karpasasthi, Kulatha, Balamula and Masha as per the standard guidelines. 400 g of Churna was taken for each day for one patient and made into a paste by adding buttermilk and Thalapothichilwas done in the evening between 4-5 pm for a duration of 48 minutes (1 Muhurtham) for 1 week. On the first day before treatment and 7th day after treatment Kirlian photograph was taken by using BiowellKirlian camera.Auras of each patient before and after treatment were compared with Kirlian software to know the changes in the energy bands. The quantitative outputs of the software were analyzed by paired t test. Results:In the Clinical trial, 6 variables-Total energy -8.6%, Health status -10%-14%, Energy reserve-10%-17%,Analysis-1.2%-8.1%,Functional condition of organs &system-5%-33%,Chakras-6%-15.1% improvement recorded after the intervention.

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Conclusion: Three variables showed statistical significance- Left energy,Energy reserve in Left hypothalamus and in Functional condition of left hypothalamus. All other variables showed statistically not significant and percentage wise weak significance. Hence null hypothesis was accepted.

PA65 295. Suddha-Asuddha Bhallataka Taila (Oil Extract From Semecarpus Anacardium)- A Sub-Acute Toxicity Evaluation Rinsitha P, Sunil Kumar S, Gauthaman M

Background:- Cancer,though enigmatic in nature is usually a slowly advancing process,which can be reverted at different stages of progression,by intervention.Bhallataka taila,the oil extract from Semecarpus anacardium is usually used as a remedy against clinical conditions like Oral Ca,Oesophageal Ca etc. Bhallataka finds a unique place among upavisas(semi poisons) due to its much widely varied applications including rasayana and vajikarana action.The sharp(teekshna) and hot (ushna) attributes of bhallataka,necessitates its usage with caution. Controversy exist among Physicians as many traditional Vaidyas claim the usage of asodhita bhallataka taila in chronic ailments.The dual nature of bhallataka taila was found worthy of exploration. Methods:-The taila extraction mentioned in Susrutha Samhita Chikitsa Sthana is considered here.The taila extraction is found in authentic textbooks including CharakaSamhita and is a clinically used medicament.But sodhana is not specifically mentioned except in Susrutha Samhita Chikitsa Sthana.The obtained purified and impurified taila was used for acute and sub-acute toxicity study. Results and Conclusion:- Here while considering the overall subacute toxicity study the drug bhallataka taila produces toxicological symptoms. In clinical practice the toxic effects are well managed with use of supportive dietary regimen including kseerodana and well pre-cautioned administration.As per the toxicological evaluation,Acute toxicity study:-LD50 of suddha bhallataka taila-less than 2000mg/Kg and LD50 of asuddha bhallataka taila-more than 2000mg/Kg. Sub acute toxicity study:-Shodhita bhallataka taila may produce higher functional disturbances while Ashoditha group may produce higher magnitude structural changes.Cyto toxic activity is very well exhibited by both.

PA66 298. Triphala Ayurvedic Mouth Rinse- Rediscovering The Past Biju Balakrishnan, Roshni Nair, Jayachandran Perayil, Angel Fenol, Lakshmi Menon, Rajesh Vyloppillil, Anuradha Bhaskar, Mohammed Shereef, Maya George, Reshma Suresh

Background: Presence of brackets and wires promote plaque accumulation in orthodontic patients resulting in periodontal disease. Essential oil containing mouth rinse (Listerine) is widely used. They contain 26% alcohol (weight by volume) as preservative, disadvantages being-burning sensation, poorly tolerated in patients with mucositis. Alcohol containing mouth rinses have been associated with oral cancer. “Triphala” is among the most common formulas used in traditional ayurvedic medicine and is mentioned throughout ancient ayurvedic medicine literature as a tonic for various ailments. Studies show Triphala plays a role in management of periodontal disease with no side effects or discomfort to the patient with long term use. Therefore, series cases to assess the efficacy of Triphala based mouth rinse in reducing gingival inflammation in patients undergoing fixed orthodontic therapy Objective: To assess the effect of triphala mouth rinse as compared to Listerine on the gingival health of patients

Book of Abstracts 121 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine undergoing fixed orthodontic therapy at an interval of 7 days and 14 days Methodology: Patients undergoing fixed orthodontic therapy with visible gingival inflammation were enrolled from the Department of Orthodontics. Gingival health and stains are evaluated. Patients underwent supra gingival scaling and were asked to use the test mouth rinses. They were reassessed after 7 days and 14 days. Result: Visible reduction in gingival inflammation in patients using Triphala based mouth rinse Conclusion: Triphala based mouth rinse may prove as an efficacious agent in reduction of gingival inflammation.

PA67 299. Onion (Allium Cepa) And Pomegranate (Punica Granatum) As Local Drug Delivery Agents In Periodontal Disease Lakshmi Puzhankara

Periodontal disease is a multifactorial disease which can be ameliorated with an integrated effort of both mechanical and chemical agents. Phytonutrients refer to plant nutrients with particular biological activities in human health. The phytonutrients have been shown to have anti-inflammatory, antioxidant, antibacterial, astringent and other properties and hence, they have been extensively used from time immemorial for restoring oral health. Onion (Allium cepa) and pomegranate (Punica granatum) extracts, in various formulations, have been used for the treatment of periodontal disease. Onion has been found to be effective against S.mutans, P.gingivalis, P.intermedia in previous studies. Efficacy of pomegranate against P.gingivalis, A.actinomycetetmcomitans, P.intermedia is also a known factor. The use of these extracts incorporated into fibers or chips, which would in turn enhance its retention at the site of periodontal destruction, has not been studied extensively. A search of literature was made on the periodontal uses of these phytonutrients and a study has been proposed to assess the efficacy of these agents incorporated into fibers and chips in moderate periodontitis. These fibers or chips may prove to be efficient local drug delivery agents which are devoid of the side effects commonly associated with the conventional antiinfectious agents. Standardization and quality assurance of these herbal remedies may pave the way to supplement or even substitute conventional antibiotics and antiseptics in the treatment of periodontitis and other biofilm- related diseases.

PA68 303. Dietary Risk Factors Of Colorectal Cancer From Ayurvedic Perspective Vineeta Awalkanthe, Sadanand Sardeshmukh, Vineeta Deshmukh, Vasanti Godse, Arvind Kulkarni, Sudha Gangal

Purpose: Diet plays an important role in maintaining health of gastrointestinal tract organs. Thus frequent consumption of unhealthy diet mentioned in Ayurvedic text is a common risk factor of gastrointestinal diseases right from Grahani to colorectal cancers. The study was carried out to establish this Siddhanta of Ayurved in colorectal cancer patients. Method: A detailed history 420 colorectal cancer patients about habits of their diet was taken. Research: The data showed over consumption of 3 dietary components such as green chili, red chili powder and Dadhi(curds) alone or in combination for many years. 257 patients out of 420 had habit of consuming green chilli approximately 2 chillies / day for an average period of 39 yrs. 214/420 patients were consuming red chilli powder, 1-1.5 tsp /day for average 31 yrs. 188/257 patients were consuming a combination of green chilli & red chilli powder in substantial amount. 158/420 patients were

Book of Abstracts 122 Amrita Samyogam 2017 International Conference on Integrative Ayurveda and Modern Medicine habitual to eat Dadhi(curd) half catori(bowl) per day, especially in dinner for average 34 yrs. However, a combination of chilli & Dadhi in significant amount was consumed by 98/257 patients for average 33 yrs & a combination of red chilli powder & Dadhi consumed by 90/214 patients for average period of 32.5 yrs. Conclusion: Chili due to its Katu Rasa and Ushna Veerys produces Shotha(inflammation), which leads to Vrana shotha and Arbuda. Similarly Dadhi (Curd) when taken in excess produces Shotha, vitiates Kapha and Pitta and produces Kleda, which is in turn responsible for malignant changes in colorectum.

PA69 304. Standardization Of Kamdudha Rasa To Understand The Mechanism Of Action As Adjunct Treatment In Management Of Chemotherapy And Radiotherapy Side Effects Sandeep Chavan, Sadanand Sardeshmukh, Vineeta Deshmukh, Sukumar Sardeshmukh

Purpose: Kamdudha Rasa, a classical formulation mentioned in Ayurveda is generally prescribed for fever, vertigo and hyperacidity. The thorough study of the ingredients categorises this medicine as coolant, appetizer and acid neutralizing formulation. Considering this fact we have been using this formulation as adjunct treatment in chemotherapy and radiotherapy side effect since years. The monograph of this formulation has not been published yet and hence was decided to standardize it for wider acceptance. Method: All raw ingredients were checked for identity, purity and strength. Standard Operating Procedures for preparation of Bhasma, purified red oche and Guduchi sattva were followed. The Bhasma were tested for particle size, XRD, SEM, FTIR and TGA. Acute toxicity study was also conducted. Finally finished product monograph was developed. Research: XRD shows Calcium carbonate in Bhasma and particle size analysis exhibits nano- particle form. FTIR shows Iron Oxide in red ochre is along with organic matrix (ghee). TGA shows that all the Bhasma are in pure form. Guduchi sattva is Tinospora sinensis starch grains with high gelation time. LD50 is more than 2000mg/kg. Conclusion: It was found that meticulous performance of all the steps mentioned in Ayurveda is essential to get desired properties. The applicability of calcium carbonate in presence of iron oxide with ghee and starch is a unique combination to maintain the gastro-intestinal and systemic pH, normal haemoglobin and bone density in cancer patients. These findings may also probe to further investigate the role of Calcium carbonate nano-particle in management of cancer metastases.

PA70 307. Comparative Study Of Yg2 And Yg3 In Yakrut Vikara (HCC, Liver cirrhosis) Bhagyashree Sardeshmukh, Shweta Gujar, Sadanand Sardeshmukh, Vineeta Deshmukh, Shreenivas Datar, Swapna Kulkarni Kulkarni, Pradnya Kodre

Purpose: The purpose of the study is to assess role of oral Ayurvedic medicines in Chronic liver diseases including HCC which is 5th most common cause of death in India. Method: A. 49 Patients of Yakrut Vikar (Hepatocellular Carcinoma, Liver metastasis, Liver cirrhosis, Hepatitis B & C), 20-70 yrs, either sex were included. B. Treatment Protocol – Study group patients (A) (n=22) received YG3 combination (Yakrut Plihari LohaVati 125 mg BD, Kutaki churna 500 mg BD morning – evening & Kumari Kalpa Vati 500 mg BD after lunch and dinner) and Control group Patients (B) (n=27) received YG2 combination (Yakrut Plihari LohaVati 125 mg BD & Kutaki churna 500 mg BD, Morning - evening) administered for the period of 6 months.C. Assessment Criteria – Symptoms of Yakrut vikara, Karnofsky Score; Biochemistry viz Hemogram, LFTs, KFTs etc. were assessed. The time points are before starting the treatment (a), middle of the treatment (b) and at the end of the treatment (c)

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Results: Significant improvement is seen in symptoms like Agnimandya (at time point b, p=0.006; time point c, p<0.0001), fullness of abdomen at time point b, p=0.017; time point c, p<0.0005), malaise (at time point b, p=0.01; time point c, p<0.0002), weakness (at time point b, p=0.008; time point c, p<0.0001). Significant increase in hemoglobin levels in Group A (p=0.046) was observed at time point b. Conclusion: Bhedana action of YG3 in Yakrut Vikara is found to be evident as compared to YG2.

PA71 308. Reduction In Score On OSwestry Disability Index In Intra Vertibral Disc Prolapse After An Ayurvedic Intervention - A Case Study Arya Somasundaran, Sasikumar VK

Rationale of this case report: Spinal disc herniation is a condition affecting the spine in which there is a Tear in the outer fibrous ring of an intervertebral disc which allows the soft central portion to bulge. Painkillers are mainly given in allopathic medication. Its long term use cause Constipation, Nausea, Gatsritis, Addiction. In ayurveda the condition can be correlate with Katigraha because of its nature, site. Presenting concerns: The present case is about 27year old lady diagnosed with IVDP, most of the symptoms similar to IVDP, includes severe, continuous, shooting and pricking type. ODI of 40% which indicates Moderate disability. Clinical tests ruled out that the pain was not a radiating type but localised at lumbar area. The MRI reveals diffuse disc bulge at L4- L5 level with impingement of nerves, mild disc bulge at L3 - L4, L5-S1 level. The patient was dependent on pain killers when admitted. Interventions: The treatment protocol included Snehapana with indukantam gritam (7 days) followed by Virechana (1 day) along with Gandarvahastadi, Astavarga kashaya and Yogaraja gugulu internally. Outcomes: At the end of 14th day, the re-assessment was done using ODI and the score reduced to 11.1%. It denotes that, treatment is effective in improving ODI within a span of 14 days. Main lesson(s) from this case report: The ODI reduced from moderate to normal disability within a short time period. The patient had significant relief without using painkillers. Further studies are needed to see whether Ayurveda has better outcomes in long term.

PA72 309. Clinical Evaluation Of Effect Of Music With Creative Visualization On Maternal Psychology Mauli Vaishnav

Objective: In today’s era, due to changes in lifestyle, burden of profession, household workload, a human’s psychosomatic systems seems to be under pressure, which can lead to stress, depression, hypertension etc. which can be worsen during pregnancy. Music and creative visualization can be good preventive therapy and remedy of them. This study was done to evaluate the effect of music with creative visualization on psychological health of the pregnant woman by using assessment Scale PSS-10. Method: It was an open randomized control clinical study where 30 singleton pregnant women diagnosed with normal pregnancy were subjected and divided into trial and control group. Subjects of trial group were exposed to music and visualization daily for ½ hour from 20 weeks of gestation up to delivery with routine antenatal care. PSS-10 was evaluated on first visit and at term. Result: PSS-10 score was found significantly reduced in trial group (t = -14.52, P <0.0001). Conclusion: Prenatal music and creative visualization exposure can considerably reduce maternal stress level and improvise mental health of to be mother.

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PA73 310. Pharmacokinetic Study Of Amaranth Extract In Healthy Humans: A Randomized Trial Swati Gupta, Deepa Subramanian

Objective: Nitric oxide (NO) is one of the most important signaling molecules produced within the body. Continuous generation of NO is essential for the integrity of the cardiovascular system. The aim of this study was to assess whether oral intake of a nitrate (NO3ˉ)-rich dietary supplement(amaranth extract) is able to increase NO3ˉ and nitrite (NO2ˉ) levels in blood plasma and saliva of healthy adults. Methods: In the present study, bioavailability and pharmacokinetics of NO3ˉ and NO2ˉ from amaranth extract (2 g as single dose) was studied in 16 healthy individuals and compared with placebo in a crossover design. The NO3ˉ and NO2ˉ levels in plasma as well as saliva were measured up to 24 h. Results: After administration of amaranth extract, the NO3ˉ levels in plasma as well as saliva were found to be significantly (P < 0.001) higher than in the placebo group. The NO2ˉ level in plasma was slightly higher (P < 0.05) in the amaranth group (test group) compared with that in the placebo group, whereas the saliva NO2ˉ level was significantly high (P < 0.001) in the amaranth extract–treated group than the placebo group. Conclusions: These results clearly indicate that a single oral dose of amaranth extract is able to increase the NO3ˉ and NO2ˉ levels in the body for at least 8 h. The increase in NO3ˉ and NO2ˉ levels can help to improve the overall performance of people involved in vigorous physical activities or sports.

PA74 313. Setting A Policy Framework For Integrated System Of Medicines Santhosh Thannikkat

Traditional and local knowledge was labeled unscientific or irrational during the British period while Western medicine was accorded the status of official medicine. Even after independence Indian politicians were stuck to the same policy segregating different systems of medicines, departmentalized medical education and practice. China has successfully integrated Traditional Chinese Medicine into allopathic system and framed their healthcare policy since 1949. There are many issues faced by the healthcare sector now: • allopathic system is criticized for profiteering and unethical practices of pharmaceutical industry along with insurance companies and private hospitals, side effects of synthetic drugs, .. • traditional systems are affected by biodiversity conservation, lack of standardization, absence of evidences for efficacy etc… A symbiotic relationship will have to be developed between the different systems of medicine, but before that, a lot of groundwork will have to be done in each system individually. Purpose of this paper is to look into the differences of systems of medicines, strength and weakness of each system from published documents. There are areas of common ground which can be extended to all the systems of medicine: learning of anatomy, use of modern lab equipments for diagnosis, etc. at the same time the marked differences need to be understood such as active ingredient, individualized treatment, role of mind, documenting cases for evidence based medicine etc. The paper will help medical practitioners from different streams to discuss and agree on a policy framework which can be implemented with the objective of providing healthcare for all.

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PA75 314. Improving Low Anti Mullerian Hormone Values For Enhancing IVF Success Rates : A Study Proposal Sithara Satheesan

Background: The IVF success rates are less than 10.5% in women with low Anti Mullerian Hormone (AMH) values. Recent studies have proven that repeated ovulation stimulation is one among the iatrogenic causes for diminished ovarian reserve. Once the AMH values are low,the patients are considered as an exclusion for further IVF. In clinical practice it is noticed that Ayurvedic treatments are having a role in improving hyperstimulation induced low AMH values(values < 1 ng/ml had an improvement of >2.5ng/ml after Ayurvedic treatments) but there is no systemic data available regarding it. Objective: The aim of the study is to systematically collect data regarding the effectiveness of Ayurvedic treatments on the ovarian reserve in patients of successive ovarian hyperstimulation induced low AMH values. Methods and Design: A prospective study on 30 patients having low AMH values(<1.5ng/ml) of age group 20yrs-45yrs having history of normal menstrual cycle and repeated ovarian stimulation.3 months of Ayurvedic treatment alone is given.The result of the study on ovarian reseve is investigated based on usg report with AMH,FSH and estradiol values on Day-3 of the menstrual cycle. Discussion: The result of the study can be utilised for systematic understanding of the effectiveness of Ayurvedic medication on ovarian reserve.The better outcomes of the study can give new hope in the integarated practice of Assited Reproductive Technologies.

PA76 317. Nephrotic Syndrome : Emerging Trends In The Managing Perspective Of Ayurveda Susmitha C , Prakash Mangalasseri

Purpose: Nephrotic syndrome is one among the dreadful disease in world scenario characterized by marked edema, hypoalbuminuria and hyperlipidemia which is classified as primary and secondary. Primary due to focal segmental glomerulosclerosis and membranous nephropathy. There is no established guidelines in the management perspective of nephrotic syndrome. Method: This study have tried to incorporate expert opinions in the scope of management of nephrotic syndrome with an experience survey and demonstrating a detailed case report which is effectively managed by 2 months OPD level medication along with strict control over diet and daily regimen. Result: Apart from inculcating angiotensin blockade, corticosteroids, immunosuppressive therapies etc- Ayurveda samana cikitsa(curative/balancing therapy) plays a life saving role in chronic ill patients with renal nephropathy. Conclusion: So an integrative approach which is holistic in nature seems to be much necessary for getting good results.

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