Supplemental Table 1: SOX2 qPCR Array ID Symbol Description Assay ID 1 CD44 CD44 (homing function and Indian blood group system) Hs00174139_m1 2 AQP4 4 Hs00242341_m1 3 GFAP glial fibrillary acidic Hs00157674_m1 4 ELAVL4 HuD Hs00222634_m1 5 CD68 CD68 antigen Hs00154355_m1 6 ASCL1 MASH1 Hs00269932_m1 7 PROM1 CD133 Hs01009257_m1 8 CD24 CD24A Hs00273561_s1 9 HES1 hairy and enhancer of split 1 Hs00172878_m1 10 PAX6 paired box gene 6 Hs01088112_m1 11 MSI1 musashi homolog 1 Hs00159291_m1 12 NES Nestin Hs00707120_s1 13 SOX2 SRY (sex determining region Y)-box 2 Hs01053049_s1 14 OLIG2 oligodendrocyte lineage transcription factor 2 Hs00377820_m1 15 SOX10 DOM; WS4; MGC15649 Hs00366918_m1 16 PDGFRA platelet-derived growth factor receptor, alpha polypeptide Hs00998026_m1 17 CSPG4 NG2 Hs00426981_m1 18 ST8SIA1 A2B5, SIAT8A, G3 synthase Hs00268157_m1 19 SLC1A3 GLAST Hs00188193_m1 20 FABP7 fatty acid binding protein 7, BLBP (Brain lipid-binding protein) Hs00361426_m1 21 TERT hTERT, Telomerase reverse transcriptase Hs00162669_m1 22 P2RY5 purinergic receptor P2Y Hs00271758_s1 23 ADORA2B adenosine A2b receptor Hs00386497_m1 24 NOG Noggin Hs00271352_s1 25 BAMBI NMA Hs00180818_m1 26 TTYH1 tweety homolog 1 (Drosophila) Hs00221061_m1 27 CD99 CD99 molecule Hs00242853_m1 28 CD58 CD58 molecule Hs00156385_m1 29 CD109 CD109 molecule Hs00370347_m1 30 CD164 sialomucin Hs00985280_m1 31 Gli3 Zinc finger protein GLI3 Hs00609233_m1 32 CDH6 cadherin 6, type 2, K-cadherin (fetal ) Hs00191832_m1 33 VEGF vascular endothelial growth factor Hs00900055_m1 34 LIFR leukemia inhibitory factor receptor; CD118 Hs00158730_m1 35 IL6ST interleukin 6 signal transducer (gp130, ); CD130 Hs00174360_m1 36 CEBPB CCAAT/enhancer binding protein (C/EBP), beta, Nuclear factor NF-IL6 Hs00270923_s1 37 NMI N-myc (and STAT) interactor Hs00190768_m1 38 SPP1 osteopontin Hs00167093_m1 39 TNFSF10 tumor factor (ligand) superfamily, member 10 Hs00234356_m1 40 TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b Hs00198106_m1 41 GDF15 growth differentiation factor 15 Hs00171132_m1 42 SHC1 SHC (Src 2 domain containing) transforming protein 1 Hs00427539_m1 43 EDG2 endothelial differentiation, G-protein-coupled receptor, 2 Hs00173500_m1 44 HES5 hairy and enhancer of split 5 (Drosophila) Hs01387463_g1 45 NOTCH2 Notch homolog 2 (Drosophila) Hs01050720_mH 46 JAG1 jagged1 Hs00164982_m1 47 NOTCH1 Notch homolog 1 Hs01062014_m1 48 NOTCH3 Notch homolog 3 (Drosophila) Hs01128541_m1 49 Hey1 HARP Hs00232618_m1 50 NEUROG1 neurogenin 1, NGN1 Hs01029249_s1 51 NEUROG2 neurogenin 2, NGN2 Hs00702774_s1 52 DLL1 delta-like 1 (Drosophila) Hs00194509_m1 53 NEUROD2 neurogenic differentiation 2 Hs00272055_s1 54 NEUROD1 neurogenic differentiation 1 Hs00159598_m1 55 NUMB numb homolog (Drosophila) Hs01105433_m1 56 HAP1 huntingtin-associated protein 1 (neuroan 1) Hs00171598_m1 57 SOX4 SRY (sex determining region Y)-box 4 Hs00268388_s1 58 ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) Hs00602749_m1 59 WEE1 WEE1 homolog, WEE1A Hs00268721_m1 60 RREB1 ras responsive element binding protein 1 Hs00366111_m1 61 WWTR1 WW domain containing transcription regulator 1 (TAZ) Hs00210007_m1 62 DACH1 dachshund homolog 1 (Drosophila) Hs00189301_m1 63 YAP1 Yes-associated protein 1, 65kDa Hs00371735_m1 64 SALL1 sal-like 1 (Drosophila) Hs00231307_m1 65 ELAVL1 Hu antigen R Hs00171309_m1 66 BTG2 BTG family, member 2; NGF-inducible anti-proliferative protein PC3, Hs00198887_m1 67 LMCD1 LIM and -rich domains 1 Hs00205871_m1 68 FGF2 basic fibroblast growth factor Hs00266645_m1 69 EGF epidermal growth factor (beta-urogastrone) Hs00153181_m1 70 NPY2R neuropeptide Y receptor Y2 Hs00168567_m1 71 WNT5A wingless-type MMTV integration site family, member 5A Hs00998537_m1 72 DAAM2 dishevelled associated activator of morphogenesis 2 Hs00322497_m1 73 LY96 lymphocyte antigen 96 Hs00209771_m1 74 AGTR1 angiotensin II receptor, type 1 Hs00258937_m1 75 FAS Fas (TNF receptor superfamily, member 6); CD95 Hs00163653_m1 76 MET met proto-oncogene (hepatocyte growth factor receptor) Hs00179845_m1 77 IL13RA2 interleukin 13 receptor, alpha 2 Hs00152924_m1 78 ITGA2 , alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) Hs00158127_m1 79 TLR3 toll-like receptor 3; CD283 antigen Hs00152933_m1 80 TLR4 toll-like receptor 4; CD284 Hs00152939_m1 81 TNFRSF10D tumor necrosis factor receptor superfamily, member 10d;CD264, TRAILR4 Hs00388742_m1 82 TNFRSF10A tumor necrosis factor receptor superfamily, member 10a; CD261, TRAILR-1 Hs00269492_m1 83 TNFRSF19 tumor necrosis factor receptor superfamily, member 19; TRADE, TROY Hs00218634_m1 84 EPHA2 ephrin receptor EPH receptor A2 Hs00171656_m1 85 PTPRG protein tyrosine , receptor type, G Hs00177193_m1 86 RGS16 regulator of G-protein signalling 16 Hs00892674_m1 87 NGFR nerve growth factor receptor; p75(NTR), CD271 Hs00609976_m1 88 NRP2 2; NPN2 Hs00187290_m1 89 PTPRZ1 RPTPzeta / phosphocan Hs00267839_m1 90 ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase2 (autotaxin) Hs00905125_m1 91 FZD8 frizzled homolog 8 (Drosophila) Hs00259040_s1 92 FZD10 frizzled homolog 10 (Drosophila) Hs00273077_s1 93 FZD6 frizzled homolog 6 (Drosophila) Hs00171574_m1 94 DKK3 dickkopf homolog 3 (Xenopus laevis) Hs00247426_m1 95 DKK1 dickkopf 1 Hs00183740_m1 Type Symbol Description GeneID Ratio P‐value Ligand GPNMB glycoprotein (transmembrane) nmb 10457 24.01 4.40E‐03 S100A6 S100 calcium binding protein A6 6277 19.25 2.42E‐02 AGTR1 angiotensin II receptor, type 1 185 18.37 1.17E‐04 NOG Noggin 9241 16.59 3.75E‐03 ADM adrenomedullin 133 13.08 1.92E‐03 SPP1 osteopontin 6696 11.89 9.21E‐04 TNFSF10 tumor necrosis factor (ligand) superfamily, 8743 11.73 7.93E‐05 member 10 ANXA1 annexin A1 301 11.68 9.37E‐04 EGF epidermal growth factor (beta‐urogastrone) 1950 9.89 1.43E‐04

DKK3 dickkopf 3 27122 9.00 1.34E‐05 TNFSF13B tumor necrosis factor (ligand) superfamily, 10673 8.80 1.96E‐02 member 13b GDF15 growth differentiation factor 15 9518 8.48 5.98E‐03 CLU clusterin 1191 8.26 4.14E‐04 IL33 interleukin 33 90865 8.07 8.17E‐05 LAMA5 laminin, alpha 5 3911 7.24 5.81E‐03 SHC1 SHC (Src homology 2 domain containing) 6464 6.86 8.44E‐04 transforming protein 1 CMTM3 CKLF‐like MARVEL transmembrane domain 123920 6.51 1.07E‐04 containing 3 CD276 CD276 molecule 80381 6.19 4.77E‐04 LRDD ‐rich repeats and 55367 5.95 9.99E‐04 containing FST follistatin 10468 5.46 9.63E‐05 TNFSF4 tumor necrosis factor (ligand) superfamily, 7292 5.45 1.12E‐02 member 4 CRH corticotropin releasing hormone 1392 5.34 2.40E‐02 EPHB4 EPH receptor B4 2050 5.33 1.84E‐03 TGFB2 transforming growth factor, beta 2 7042 5.32 5.03E‐03 GRN granulin 2896 5.20 3.90E‐04 PHIP pleckstrin homology domain interacting 55023 5.14 7.34E‐03 protein ITGA5 integrin, alpha 5 (fibronectin receptor, alpha 3678 5.01 2.04E‐03 polypeptide) ANGPTL2 angiopoietin‐like 2 23452 4.74 3.13E‐03 ADAM9 ADAM metallopeptidase domain 9 (meltrin 8754 4.36 1.64E‐03 gamma) APOL2 apolipoprotein L, 2 23780 4.35 2.51E‐03 MSN moesin 4478 4.34 8.69E‐03 TNC tenascin C 3371 4.27 5.52E‐04 SQSTM1 sequestosome 1 8878 4.26 5.71E‐04 SERPINE1 serpin peptidase inhibitor, clade E (nexin, 5054 4.18 1.36E‐03 plasminogen activator inhibitor type 1), member 1 ANGPTL1 angiopoietin‐like 1 9068 4.15 5.62E‐03 Receptor ELTD1 EGF, latrophilin and seven transmembrane 64123 33.92 3.94E‐03 domain containing 1 FZD10 frizzled 10 11211 33.20 9.80E‐06 LY96 lymphocyte antigen 96 23643 24.07 2.17E‐02 CFI 3426 20.74 1.54E‐02 F2RL2 coagulation factor II () receptor‐like 2151 18.93 1.48E‐03 2 Type Symbol Description GeneID Ratio P‐value TRPM3 transient receptor potential cation channel, 80036 18.92 4.68E‐05 subfamily M, member 3 CD44 CD44 antigen (homing function and Indian 960 16.38 1.77E‐05 blood group system) EDNRB endothelin receptor type B 1910 14.01 1.60E‐06 IL13RA2 interleukin 13 receptor, alpha 2 3598 13.99 1.02E‐03 MET met proto‐oncogene (hepatocyte growth 4233 13.00 2.61E‐03 factor receptor) ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of 3673 12.95 2.57E‐04 VLA‐2 receptor) NPY2R neuropeptide Y receptor Y2 4887 12.64 5.37E‐04 TNFRSF10D tumor necrosis factor receptor superfamily, 8793 12.07 1.62E‐03 member 10d, decoy with truncated death domain LRP10 low density lipoprotein receptor‐related 26020 11.92 4.98E‐03 protein 10 GEM GTP binding protein overexpressed in 2669 11.84 5.07E‐05 skeletal muscle FAS tumor necrosis factor receptor superfamily, 355 10.84 7.30E‐06 member 6 TLR4 toll‐like receptor 4 7099 10.40 3.84E‐05 TLR3 toll‐like receptor 3 7098 10.30 1.22E‐04 FBN1 fibrillin 1 2200 9.64 9.73E‐05 WEE1 WEE1 homolog (S. pombe) 7465 9.38 3.63E‐04 DAAM2 dishevelled associated activator of 23500 8.83 2.92E‐04 morphogenesis 2 NOTCH2 Notch homolog 2 (Drosophila) 4853 8.53 4.67E‐03 GNG12 guanine nucleotide binding protein (G 55970 8.13 1.62E‐03 protein), gamma 12 BAMBI NMA 25805 8.06 2.44E‐03 HRH1 histamine receptor H1 3269 8.02 9.92E‐04 LGALS3BP lectin, galactoside‐binding, soluble, 3 binding 3959 7.85 7.49E‐05 protein LTBP1 latent transforming growth factor beta 4052 7.69 1.19E‐03 binding protein 1 HLA‐E major histocompatibility complex, class I, E 3133 7.24 2.86E‐04

TNFRSF19 tumor necrosis factor receptor superfamily, 55504 7.20 3.36E‐06 member 19 EPHA2 ephrin receptor EphA2 1969 7.17 6.05E‐05 CLIC1 chloride intracellular channel 1 1192 7.01 9.97E‐04 LIFR leukemia inhibitory factor receptor 3977 6.74 2.89E‐04 NGFR p75(NTR) 4804 6.42 2.17E‐03 IL6ST interleukin 6 signal transducer (gp130, 3572 6.31 6.24E‐04 oncostatin M receptor) P2RY5 purinergic receptor P2Y 10161 6.17 9.46E‐04 RGS16 regulator of G‐protein signalling 16 6004 6.12 9.03E‐05 MRC2 , C type 2 9902 6.02 2.72E‐03 TNFRSF10A tumor necrosis factor receptor superfamily, 8797 5.84 5.24E‐05 member 10a RRBP1 ribosome binding protein 1 homolog 180kDa 6238 5.80 9.58E‐05 (dog) ADORA2B adenosine A2b receptor 136 5.54 1.11E‐02 RAB31 RAB31, member RAS oncogene family 11031 5.16 4.14E‐05 NRP2 VEGF165R2 8828 4.88 3.21E‐05 Type Symbol Description GeneID Ratio P‐value IGSF10 immunoglobulin superfamily, member 10 285313 4.81 2.35E‐03

SRPR signal recognition particle receptor ('docking 6734 4.60 2.34E‐05 protein') MERTK c‐mer proto‐oncogene tyrosine kinase 10461 4.58 2.49E‐06 HLA‐B major histocompatibility complex, class I, B 3106 4.55 7.78E‐03

HLA‐G HLA‐G histocompatibility antigen, class I, G 3135 4.48 6.28E‐03

UNC5B unc‐5 homolog B (C. elegans) 219699 4.36 1.54E‐02 LPAR1 vzg‐1, LPA1 1902 4.22 3.80E‐03 FZD6 frizzled 6 8323 4.02 5.69E‐04 ECM / Cell adhesion LUM lumican 4060 22.66 9.43E‐04 ADAMTS9 ADAM metallopeptidase with 56999 16.34 1.10E‐03 thrombospondin type 1 motif, 9 ADAMTS1 ADAM metallopeptidase with 9510 13.94 1.57E‐06 thrombospondin type 1 motif, 1 ITGB5 integrin, beta 5 3693 12.45 3.82E‐04 CD99 CD99 molecule 4267 11.84 1.06E‐04 MEGF10 multiple EGF‐like‐domains 10 84466 11.55 4.07E‐04 TIMP1 TIMP metallopeptidase inhibitor 1 7076 10.08 1.98E‐03 DSG2 desmoglein 2 1829 9.77 8.19E‐03 LAMB2 laminin, beta 2 (laminin S) 3913 9.21 1.16E‐02 CDH6 cadherin 6, type 2, K‐cadherin (fetal kidney) 1004 9.18 1.76E‐04

CTHRC1 collagen triple helix repeat containing 1 115908 9.12 7.58E‐04

ANXA2 annexin A2 302 9.00 2.18E‐03 GPC6 glypican 6 10082 8.76 8.76E‐04 COL5A1 collagen, type V, alpha 1 1289 8.75 9.76E‐04 ALOX12 arachidonate 12‐lipoxygenase 239 8.32 7.72E‐04 NCAM1 NCAM 4684 8.26 2.99E‐04 TTYH1 tweety homolog 1 (Drosophila) 57348 8.23 3.67E‐05 CD164 CD164 molecule, sialomucin 8763 7.62 1.02E‐03 PERP PERP, TP53 effector 64065 7.38 1.25E‐04 LAMC1 laminin, gamma 1 (formerly LAMB2) 3915 7.04 9.85E‐06 CD58 CD58 molecule 965 6.76 4.40E‐05 AMIGO2 adhesion molecule with Ig‐like domain 2 347902 6.71 4.75E‐03

FBLN2 fibulin 2 2199 6.61 1.75E‐04 NINJ1 ninjurin 1 4814 6.59 2.21E‐03 HAPLN4 hyaluronan and proteoglycan link protein 4 404037 6.36 1.10E‐02

ITGA6 integrin, alpha 6 3655 6.17 2.73E‐03 DSC3 desmocollin 3 1825 6.09 2.01E‐03 TLN2 talin 2 83660 5.97 2.58E‐04 ADAM12 ADAM metallopeptidase domain 12 8038 5.82 1.44E‐03 MMP2 matrix metalloproteinase 2 (gelatinase A, 4313 5.42 1.82E‐03 72kDa gelatinase, 72kDa type IV collagenase)

COL5A2 collagen, type V, alpha 2 1290 5.35 7.49E‐05 MMP14 matrix metallopeptidase 14 (membrane‐ 4323 5.03 1.61E‐04 inserted) SDK2 sidekick homolog 2 (chicken) 54549 4.80 1.28E‐02 ITGA7 integrin, alpha 7 3679 4.69 7.03E‐03 Type Symbol Description GeneID Ratio P‐value COL4A2 collagen, type IV, alpha 2 1284 4.32 8.81E‐04 COL27A1 collagen, type XXVII, alpha 1 85301 4.31 3.50E‐04 AEBP1 AE binding protein 1 165 4.27 2.94E‐04 COL6A1 collagen, type VI, alpha 1 1291 4.18 2.82E‐04 FREM2 FRAS1 related extracellular matrix protein 2 341640 4.11 1.94E‐02

FBN2 fibrillin 2 (congenital contractural 2201 4.04 2.11E‐03 arachnodactyly) CRTAP cartilage associated protein 10491 4.00 1.59E‐03 / Catalytic RAP1A RAP1A, member of RAS oncogene family 5906 29.74 1.38E‐03 activity LEPREL1 leprecan‐like 1 55214 23.50 4.00E‐04 NQO1 NAD(P)H dehydrogenase, quinone 1 1728 20.83 9.90E‐04 ATP10B ATPase, Class V, type 10B 23120 19.90 3.95E‐05 THSD4 thrombospondin, type I, domain containing 4 79875 16.31 2.27E‐05

AKR1C3 aldo‐keto reductase family 1, member C3 (3‐ 8644 15.59 4.65E‐05 alpha hydroxysteroid dehydrogenase, type II) CDKN2B p15, inhibits CDK4 1030 15.48 9.74E‐06 GBP3 guanylate binding protein 3 2635 15.33 2.61E‐02 HS3ST3A1 heparan sulfate (glucosamine) 3‐O‐ 9955 14.92 3.07E‐05 3A1 EYA4 eyes absent homolog 4 (Drosophila) 2070 14.41 1.25E‐03 HEPH hephaestin 9843 12.34 4.76E‐05 GBP1 guanylate binding protein 1, interferon‐ 2633 11.81 8.10E‐03 inducible, 67kDa FOLH1 folate (prostate‐specific 2346 11.78 8.58E‐04 membrane antigen) 1 MSRB3 methionine sulfoxide reductase B3 253827 11.70 6.09E‐04 QPRT quinolinate phosphoribosyltransferase 23475 11.49 2.45E‐04 EHD2 EH‐domain containing 2 30846 10.36 3.93E‐06 ERAP2 endoplasmic reticulum 2 64167 10.33 3.82E‐02

FKBP10 FK506 binding protein 10, 65 kDa 60681 10.30 1.04E‐03 HHAT hedgehog acyltransferase 55733 9.82 1.30E‐04 SIAE sialic acid 54414 9.77 2.39E‐04 PKIB protein kinase (cAMP‐dependent, catalytic) 5570 9.60 2.10E‐04 inhibitor beta NRK Nik related kinase 203447 9.35 3.67E‐04 TP53I3 tumor protein inducible protein 3 9540 9.28 1.35E‐03 MAGT1 1 84061 9.15 2.62E‐04 SCPEP1 1 59342 8.81 3.58E‐03 GNG11 guanine nucleotide binding protein (G 2791 8.81 1.77E‐03 protein), gamma 11 HTATIP2 HIV‐1 Tat interactive protein 2, 30kDa 10553 8.77 1.64E‐04 ACSS3 acyl‐CoA synthetase short‐chain family 79611 8.73 7.02E‐03 member 3 HKDC1 domain containing 1 80201 8.67 9.61E‐03 GLT8D4 8 domain containing 4 727936 8.62 4.88E‐03

GLUD2 glutamate dehydrogenase 2 2747 8.58 2.52E‐04 CA12 carbonic anhydrase XII 771 8.48 2.06E‐05 CYP39A1 cytochrome P450, family 39, subfamily A, 51302 8.30 1.95E‐04 polypeptide 1 Type Symbol Description GeneID Ratio P‐value CDKN1A P21, CIP1 1026 8.29 3.71E‐04 GATM amidinotransferase (L‐ 2628 8.22 8.75E‐05 arginine:glycine amidinotransferase) CASP1 1, apoptosis‐related cysteine 834 8.12 8.96E‐04 peptidase (interleukin 1, beta, convertase)

CA2 carbonic anhydrase II 760 8.11 1.66E‐03 ENPP2 ectonucleotide 5168 7.98 3.80E‐04 pyrophosphatase/ 2 (autotaxin) P4HA2 procollagen‐, 2‐oxoglutarate 4‐ 8974 7.63 1.34E‐04 dioxygenase (proline 4‐hydroxylase), alpha polypeptide II HERC6 hect domain and RLD 6 55008 7.63 8.10E‐05 NT5E 5'‐, ecto (CD73) 4907 7.60 6.40E‐03 RNF128 ring finger protein 128 79589 7.50 6.39E‐03 CASP7 caspase 7, apoptosis‐related cysteine 840 7.42 2.48E‐03 peptidase PAPPA pregnancy‐associated plasma protein A, 5069 7.40 2.02E‐04 pappalysin 1 ME1 malic enzyme 1, NADP(+)‐dependent, 4199 7.32 6.07E‐03 cytosolic RP5‐1022P6.2 hypothetical protein KIAA1434 56261 7.31 7.39E‐06 CHSY3 chondroitin sulfate synthase 3 337876 7.25 5.16E‐04 RAG1 recombination activating gene 1 5896 7.14 3.57E‐04 NES Nestin 10763 7.08 4.01E‐03 TRIM5 tripartite motif‐containing 5 85363 6.92 3.38E‐03 ABCB4 ATP‐binding cassette, sub‐family B 5244 6.91 3.75E‐03 (MDR/TAP), member 4 GPX8 glutathione peroxidase 8 (putative) 493869 6.90 1.81E‐03 PTPRG protein tyrosine phosphatase, receptor type, 5793 6.89 4.54E‐04 G PPIC peptidylprolyl C (cyclophilin C) 5480 6.88 1.15E‐03

C14orf149 14 open reading frame 149 112849 6.67 2.11E‐04

FUCA2 fucosidase, alpha‐L‐ 2, plasma 2519 6.40 6.94E‐04 CTSA A 5476 6.38 5.89E‐05 ARSJ family, member J 79642 6.37 1.02E‐02 TPP1 I 1200 6.37 1.19E‐04 RHOC ras homolog gene family, member C 389 6.32 1.17E‐03 CTSO cathepsin O 1519 6.32 2.69E‐05 ATG7 ATG7 autophagy related 7 homolog (S. 10533 6.30 9.90E‐05 cerevisiae) CA13 carbonic anhydrase XIII 377677 6.26 4.04E‐04 CPT1A carnitine palmitoyltransferase 1A (liver) 1374 6.25 4.17E‐04

NAPEPLD N‐acyl phosphatidylethanolamine 222236 6.21 8.57E‐05 D FAM108A1 family with sequence similarity 108, member 81926 6.17 1.40E‐04 A1 MAPKAPK3 mitogen‐activated protein kinase‐activated 7867 6.13 2.58E‐04 protein kinase 3 CTSC 1075 6.12 6.89E‐03 RHOJ ras homolog gene family, member J 57381 6.06 1.60E‐04 Type Symbol Description GeneID Ratio P‐value ST6GALNAC5 ST6 (alpha‐N‐acetyl‐neuraminyl‐2,3‐beta‐ 81849 6.05 2.60E‐04 galactosyl‐1,3)‐N‐acetylgalactosaminide alpha‐2,6‐sialyltransferase 5

PGPEP1 pyroglutamyl‐peptidase I 54858 5.91 4.85E‐05 MYO1E myosin IE 4643 5.82 1.34E‐04 MOV10 Mov10, Moloney leukemia virus 10, homolog 4343 5.71 5.80E‐03 (mouse) P4HB procollagen‐proline, 2‐oxoglutarate 4‐ 5034 5.68 3.92E‐05 dioxygenase (proline 4‐hydroxylase), beta polypeptide ACP6 6, lysophosphatidic 51205 5.66 1.29E‐02 PRCP prolylcarboxypeptidase (angiotensinase C) 5547 5.58 7.87E‐04

PIPOX pipecolic acid oxidase 51268 5.55 2.26E‐04 KATNAL1 katanin p60 subunit A‐like 1 84056 5.48 3.23E‐03 PLAT plasminogen activator, tissue 5327 5.36 1.29E‐03 PARP12 poly (ADP‐ribose) polymerase family, 64761 5.24 1.47E‐03 member 12 HEXB B (beta polypeptide) 3074 5.24 1.77E‐04 CROT carnitine O‐octanoyltransferase 54677 5.19 4.79E‐06 HNMT histamine N‐methyltransferase 3176 5.15 3.11E‐04 CHST3 carbohydrate (chondroitin 6) 9469 5.15 9.32E‐03 sulfotransferase 3 GLT25D2 glycosyltransferase 25 domain containing 2 23127 5.09 7.07E‐03

ACOT8 acyl‐CoA 8 10005 5.06 2.58E‐02 ENDOD1 KIAA0830 protein 23052 4.96 5.19E‐05 BCKDHB branched chain keto acid dehydrogenase E1, 594 4.88 3.15E‐03 beta polypeptide CEPT1 choline/ethanolamine phosphotransferase 1 10390 4.82 1.69E‐03

FHIT fragile histidine triad gene 2272 4.81 7.90E‐03 TNS1 tensin 1 7145 4.68 2.21E‐03 CDKL3 cyclin‐dependent kinase‐like 3 51265 4.65 9.60E‐03 DPM3 dolichyl‐phosphate mannosyltransferase 54344 4.64 2.44E‐03 polypeptide 3 HS3ST3B1 heparan sulfate (glucosamine) 3‐O‐ 9953 4.60 8.37E‐03 sulfotransferase 3B1 PPAT phosphoribosyl pyrophosphate 5471 4.57 2.83E‐03 amidotransferase TDO2 tryptophan 2,3‐dioxygenase 6999 4.57 1.08E‐02 HDHD1A haloacid dehalogenase‐like hydrolase 8226 4.51 1.11E‐04 domain containing 1A HMGCL 3‐hydroxymethyl‐3‐methylglutaryl‐ 3155 4.47 2.01E‐02 Coenzyme A MCM9 minichromosome maintenance complex 254394 4.46 2.40E‐03 component 9 SEPT9 septin 9 10801 4.39 8.26E‐03 B3GALTL beta 1,3‐galactosyltransferase‐like 145173 4.37 2.03E‐02 RHOQ ras homolog gene family, member Q 23433 4.31 1.86E‐03 DHRSX dehydrogenase/reductase (SDR family) X‐ 207063 4.29 1.10E‐04 linked PARP9 poly (ADP‐ribose) polymerase family, 83666 4.29 3.47E‐03 member 9 Type Symbol Description GeneID Ratio P‐value PSMB9 proteasome (prosome, macropain) subunit, 5698 4.26 1.38E‐02 beta type, 9 (large multifunctional peptidase 2) CASP3 caspase 3, apoptosis‐related cysteine 836 4.18 1.77E‐04 peptidase MAP2K6 mitogen‐activated protein kinase kinase 6 5608 4.16 2.08E‐03

GNS glucosamine (N‐acetyl)‐6‐ 2799 4.15 9.61E‐04 ARL1 ADP‐ribosylation factor‐like 1 400 4.14 3.29E‐04 OGT O‐linked N‐acetylglucosamine (GlcNAc) 8473 4.12 1.35E‐02 (UDP‐N‐ acetylglucosamine:polypeptide‐N‐ acetylglucosaminyl transferase) NMT1 N‐myristoyltransferase 1 4836 4.09 1.41E‐04 DDX60L DEAD (Asp‐Glu‐Ala‐Asp) box polypeptide 60‐ 91351 4.05 1.03E‐02 like FUT9 fucosyltransferase 9 (alpha (1,3) 10690 4.04 9.08E‐03 fucosyltransferase) RNF213 ring finger protein 213 57674 4.04 9.63E‐04 PARP14 KIAA1268 protein 54625 4.04 5.54E‐03 GTPBP2 GTP binding protein 2 54676 4.01 5.85E‐03 MOXD1 monooxygenase, DBH‐like 1 26002 4.00 6.41E‐03 Transcription Factor TAF7L TAF7‐like RNA polymerase II, TATA box 54457 13.32 7.26E‐04 binding protein (TBP)‐associated factor, 50kDa PBXIP1 pre‐B‐cell leukemia homeobox interacting 57326 10.54 9.62E‐05 protein 1 CSDA cold shock domain protein A 8531 8.95 8.53E‐05 RREB1 ras responsive element binding protein 1 6239 8.60 2.06E‐02

ZIC1 Zic family member 1 (odd‐paired homolog, 7545 8.46 2.58E‐03 Drosophila) MED12L mediator complex subunit 12‐like 116931 8.27 5.50E‐05 ASXL2 additional sex combs like 2 (Drosophila) 55252 8.22 2.39E‐02

HIST1H2BK histone cluster 1, H2bk 85236 7.23 5.52E‐04 HIST1H1C histone cluster 1, H1c 3006 7.14 8.33E‐04 HIST1H2AG histone cluster 1, H2ag 8969 6.60 3.23E‐05 ZNF841 zinc finger protein 841 284371 6.40 1.42E‐04 CEBPB IL6DBP 1051 6.27 6.94E‐04 CREB3L1 cAMP responsive element binding protein 3‐ 90993 6.21 2.82E‐03 like 1 DACH1 dachshund homolog 1 (Drosophila) 1602 5.96 4.04E‐02 PPARA PPAR alpha 5465 5.92 6.18E‐04 ZNF789 zinc finger protein 789 285989 5.73 1.83E‐03 SP100 SP100 nuclear antigen 6672 5.47 1.78E‐03 THAP2 THAP domain containing, apoptosis 83591 5.30 8.20E‐04 associated protein 2 HIST1H2BH histone cluster 1, H2bh 8345 5.30 2.94E‐03 YAP1 Yes‐associated protein 1, 65kDa 10413 5.25 8.20E‐04 SALL1 sal‐like 1 (Drosophila) 6299 5.23 4.42E‐03 HIST1H2AK histone cluster 1, H2ak 8330 5.17 7.91E‐03 ELF1 E74‐like factor 1 (ets domain transcription 1997 5.16 3.93E‐03 factor) Type Symbol Description GeneID Ratio P‐value ELK3 ELK3, ETS‐domain protein (SRF accessory 2004 5.08 1.33E‐04 protein 2) MSI2 musashi homolog 2 124540 5.03 3.37E‐04 TCEA3 transcription elongation factor A (SII), 3 6920 4.83 1.31E‐04 PIR pirin (iron‐binding nuclear protein) 8544 4.73 4.87E‐03 ABTB2 ankyrin repeat and BTB (POZ) domain 25841 4.66 1.98E‐04 containing 2 HIST2H2AA3 histone cluster 2, H2aa3 8337 4.62 3.49E‐04 SP110 SP110 nuclear body protein 3431 4.56 4.51E‐04 NMI N‐myc (and STAT) interactor 9111 4.54 4.46E‐03 TCEA2 transcription elongation factor A (SII), 2 6919 4.43 5.68E‐04 HIST1H2BD histone cluster 1, H2bd 3017 4.37 2.15E‐04 ELAVL1 HuR 1994 4.33 4.02E‐03 BTG2 BTG family, member 2 7832 4.25 3.53E‐05 HES1 hairy and enhancer of split 1 3280 4.17 2.41E‐03 LMCD1 LIM and cysteine‐rich domains 1 29995 4.16 4.23E‐05 ZNF226 zinc finger protein 226 7769 4.15 1.41E‐05 WWTR1 WW domain containing transcription 25937 4.11 2.45E‐02 regulator 1 STAT6 signal transducer and activator of 6778 4.08 5.16E‐03 transcription 6, interleukin‐4 induced NFIC nuclear factor I/C (CCAAT‐binding 4782 4.05 3.33E‐03 transcription factor) Other / Novel SLC1A3 GLAST 6507 25.01 1.70E‐03 PIWIL1 piwi‐like 1 (Drosophila) 9271 23.63 4.28E‐04 FAM148A family with sequence similarity 148, member 145741 22.13 2.25E‐03 A S100A11 S100 calcium binding protein A11 6282 20.50 2.97E‐04 (calgizzarin) LOC284454 hypothetical protein LOC284454 284454 20.35 9.60E‐05 HIST1H4E histone cluster 1, H4e 8367 16.65 3.49E‐05 HIST1H2AM histone cluster 1, H2am 8336 15.65 7.36E‐03 SCN4B , voltage‐gated, type IV, beta 6330 15.37 1.19E‐02

CD109 CD109 molecule 135228 14.88 1.13E‐03 COL22A1 collagen, type XXII, alpha 1 169044 14.41 1.01E‐04 SEC16B SEC16 homolog B (S. cerevisiae) 89866 14.06 6.09E‐05 TSGA10 testis specific, 10 80705 13.55 2.70E‐03 MTTP microsomal triglyceride transfer protein 4547 13.51 1.02E‐04

TTC23 tetratricopeptide repeat domain 23 64927 13.03 4.78E‐05 S100A13 S100 calcium binding protein A13 6284 12.70 2.77E‐03 MLC1 megalencephalic leukoencephalopathy with 23209 12.45 6.82E‐05 subcortical cysts 1 C21orf62 open reading frame 62 56245 11.97 5.89E‐04 ACTA2 actin, alpha 2, smooth muscle, aorta 59 11.83 2.17E‐04 RBM47 RNA binding motif protein 47 54502 11.69 2.12E‐03 FAM125A family with sequence similarity 125, member 93343 11.62 7.02E‐05 A C14orf181 chromosome 14 open reading frame 181 400223 11.47 1.59E‐02

TRIM56 tripartite motif‐containing 56 81844 11.44 1.70E‐02 PLTP phospholipid transfer protein 5360 11.42 2.69E‐04 C6orf141 chromosome 6 open reading frame 141 135398 11.26 2.18E‐03 Type Symbol Description GeneID Ratio P‐value FAM46A family with sequence similarity 46, member 55603 11.01 1.31E‐04 A CCDC102B coiled‐coil domain containing 102B 79839 10.97 2.81E‐03 PRR16 proline rich 16 51334 10.67 1.32E‐04 CAV1 caveolin 1, caveolae protein, 22kDa 857 10.53 1.57E‐03 RASEF RAS and EF‐hand domain containing 158158 10.51 1.20E‐03 LOC389895 hypothetical LOC389895 389895 10.25 2.70E‐04 FLJ45244 hypothetical FLJ45244 400242 10.03 7.63E‐03 TSKU tsukushin 25987 9.94 3.17E‐02 PMP22 peripheral myelin protein 22 5376 9.70 1.43E‐04 RHPN2 rhophilin, Rho GTPase binding protein 2 85415 9.64 1.20E‐03

TAGLN2 transgelin 2 8407 9.61 1.29E‐04 C4orf18 open reading frame 18 51313 9.54 3.33E‐03 FAM148B family with sequence similarity 148, member 388125 9.50 6.76E‐04 B CAV2 caveolin 2 858 9.36 5.21E‐04 HIST1H4D histone cluster 1, H4d 8360 9.33 2.90E‐04 ORAI3 ORAI calcium release‐activated calcium 93129 9.22 9.06E‐05 modulator 3 PDLIM4 PDZ and LIM domain 4 8572 9.20 1.74E‐03 SLC26A7 solute carrier family 26, member 7 115111 9.16 1.16E‐03 ITM2C integral membrane protein 2C 81618 9.14 7.26E‐05 PPP1R3B 1, regulatory (inhibitor) 79660 9.08 3.36E‐04 subunit 3B S100A11P S100 calcium binding protein A11 729659 8.85 1.31E‐02 pseudogene ELMOD2 ELMO/CED‐12 domain containing 2 255520 8.79 5.05E‐03 MLF2 myeloid leukemia factor 2 8079 8.74 8.59E‐03 C1QTNF5 C1q and tumor necrosis factor related 114902 8.43 2.06E‐06 protein 5 SLC16A6 solute carrier family 16, member 6 9120 8.39 2.80E‐03 (monocarboxylic acid transporter 7) SLC15A2 solute carrier family 15 (H+/peptide 6565 8.33 6.67E‐03 transporter), member 2 CCDC80 coiled‐coil domain containing 80 151887 8.31 3.07E‐03 TCTE3 t‐complex‐associated‐testis‐expressed 3 6991 8.28 1.15E‐03

PFN4 profilin family, member 4 375189 8.27 1.53E‐03 HAP1 huntingtin‐associated protein 1 9001 7.98 5.65E‐03 REEP3 receptor accessory protein 3 221035 7.98 6.24E‐05 KCNJ10 potassium inwardly‐rectifying channel, 3766 7.97 3.86E‐02 subfamily J, member 10 SERPINH1 serpin peptidase inhibitor, clade H (heat 871 7.92 5.68E‐05 shock protein 47), member 1, (collagen binding protein 1) RASSF10 Ras association (RalGDS/AF‐6) domain family 644943 7.77 1.93E‐02 (N‐terminal) member 10 CAST 831 7.77 7.45E‐04 LOC387941 hypothetical LOC387941 387941 7.74 6.80E‐05 FIS1 fission 1 (mitochondrial outer membrane) 51024 7.74 2.88E‐03 homolog (S. cerevisiae) BST2 bone marrow stromal cell antigen 2 684 7.69 5.60E‐03 TANC1 tetratricopeptide repeat, ankyrin repeat and 85461 7.64 2.23E‐04 coiled‐coil containing 1 Type Symbol Description GeneID Ratio P‐value FLJ37644 hypothetical gene supported by AK094963 400618 7.63 3.29E‐03

NCRNA00152 non‐protein coding RNA 152 112597 7.60 1.48E‐03 WIPF1 WAS/WASL interacting , 7456 7.55 5.30E‐03 member 1 TRIM14 tripartite motif‐containing 14 9830 7.48 5.08E‐03 KCNK10 , subfamily K, member 10 54207 7.48 2.13E‐05

MGC11082 hypothetical LOC84777 84777 7.44 1.26E‐02 LOC284033 hypothetical LOC284033 284033 7.40 6.61E‐03 SLC10A4 solute carrier family 10 (sodium/bile acid 201780 7.35 1.89E‐03 cotransporter family), member 4 ORAOV1 oral overexpressed 1 220064 7.33 4.27E‐03 MAMDC2 MAM domain containing 2 256691 7.30 3.83E‐03 TMEM88B Transmembrane protein 88B 643965 7.29 5.71E‐03 NOTCH2NL Notch homolog 2 (Drosophila) N‐terminal 388677 7.29 2.48E‐04 like DDIT4L DNA‐damage‐inducible transcript 4‐like 115265 7.17 1.59E‐03

ITPRIPL2 inositol 1,4,5‐triphosphate receptor 162073 7.00 2.60E‐05 interacting protein‐like 2 HIST1H3H histone cluster 1, H3h 8357 6.97 7.39E‐07 VWA5A loss of heterozygosity, 11, chromosomal 4013 6.93 1.08E‐05 region 2, gene A DENND1A DENN/MADD domain containing 1A 57706 6.84 4.39E‐03 STOM stomatin 2040 6.78 1.07E‐05 KCNE4 potassium voltage‐gated channel, Isk‐related 23704 6.74 1.53E‐02 family, member 4 OBFC2A oligonucleotide/oligosaccharide‐binding fold 64859 6.69 3.42E‐05 containing 2A FAM129A family with sequence similarity 129, member 116496 6.63 6.83E‐03 A HSPB6 heat shock protein, alpha‐crystallin‐related, 126393 6.62 3.63E‐03 B6 EMP3 epithelial membrane protein 3 2014 6.57 5.30E‐04 ZCCHC3 zinc finger, CCHC domain containing 3 85364 6.54 4.05E‐05 LRRC17 leucine rich repeat containing 17 10234 6.51 5.79E‐04 WDR42A WD repeat domain 42A 50717 6.50 8.95E‐03 PTGFRN prostaglandin F2 receptor negative regulator 5738 6.30 7.35E‐04

SDC2 syndecan 2 (heparan sulfate proteoglycan 1, 6383 6.25 8.77E‐03 cell surface‐associated, fibroglycan)

LAMP2 lysosomal‐associated membrane protein 2 3920 6.24 8.49E‐04

MOBKL2B MOB1, Mps One Binder kinase activator‐like 79817 6.17 1.47E‐04 2B (yeast) LOC644010 hypothetical LOC644010 644010 6.09 3.79E‐03 RBPMS2 RNA binding protein with multiple splicing 2 348093 6.09 1.20E‐04

HIST1H2BE histone cluster 1, H2be 8344 6.06 2.75E‐04 CLEC2B C‐type lectin domain family 2, member B 9976 6.06 8.97E‐04

DRAM damage‐regulated autophagy modulator 55332 6.06 5.56E‐05 Type Symbol Description GeneID Ratio P‐value FAM181B family with sequence similarity 181, member 220382 6.03 2.23E‐03 B RGS3 regulator of G‐protein signalling 3 5998 6.01 2.66E‐03 HIST1H2AE histone cluster 1, H2ae 3012 6.01 2.85E‐04 C5orf32 chromosome 5 open reading frame 32 84418 5.99 2.12E‐04 TP53TG1 TP53 target 1 (non‐protein coding) 11257 5.97 1.52E‐04 HIST1H2AI histone cluster 1, H2ai 8329 5.90 2.05E‐02 RPE65 retinal pigment epithelium‐specific protein 6121 5.87 1.12E‐02 65kDa LOC728686 hypothetical LOC728686 728686 5.83 1.61E‐03 FLJ46875 hypothetical LOC440918 440918 5.83 5.25E‐03 ANXA5 308 5.82 3.39E‐03 PLEKHG1 pleckstrin homology domain containing, 57480 5.82 1.94E‐03 family G (with RhoGef domain) member 1

CD59 CD59 antigen p18‐20 (antigen identified by 966 5.81 2.08E‐04 monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) CBLN1 cerebellin 1 precursor 869 5.79 9.56E‐04 DKFZP564O0823 DKFZP564O0823 protein 25849 5.70 1.88E‐03 WSCD1 WSC domain containing 1 23302 5.66 8.56E‐03 SSFA2 sperm specific antigen 2 6744 5.57 8.51E‐05 SLC25A18 solute carrier family 25 (mitochondrial 83733 5.49 2.24E‐02 carrier), member 18 SLC4A4 solute carrier family 4, sodium bicarbonate 8671 5.47 3.33E‐03 cotransporter, member 4 IFITM1 interferon induced transmembrane protein 1 8519 5.45 3.31E‐03 (9‐27) KPNA1 karyopherin alpha 1 ( alpha 5) 3836 5.39 2.66E‐04 SYPL1 synaptophysin‐like 1 6856 5.36 7.99E‐05 SASH1 SAM and SH3 domain containing 1 23328 5.35 2.43E‐03 TRIM6 tripartite motif‐containing 6 117854 5.35 1.36E‐03 KLC1 kinesin chain 1 3831 5.34 1.57E‐03 SYNM synemin, intermediate filament protein 23336 5.34 5.29E‐03

LOC440957 similar to CG32736‐PA 440957 5.28 2.64E‐04 FNDC3B fibronectin type III domain containing 3B 64778 5.28 1.27E‐03

BAALC brain and acute leukemia, cytoplasmic 79870 5.28 4.64E‐03 LOC644656 hypothetical protein LOC644656 644656 5.23 7.71E‐03 C13orf18 open reading frame 18 80183 5.23 2.10E‐03 CALU calumenin 813 5.19 2.98E‐04 TMEM45A transmembrane protein 45A 55076 5.17 7.49E‐03 PLA2G16 HRAS‐like suppressor 3 11145 5.13 3.38E‐04 NCRNA00084 non‐protein coding RNA 84 283131 5.13 3.56E‐03 HIST1H2BF histone cluster 1, H2bf 8343 5.08 1.14E‐03 TCTN3 tectonic family member 3 26123 5.08 1.04E‐06 ERLIN2 ER lipid raft associated 2 11160 5.07 3.23E‐04 TMEM64 transmembrane protein 64 169200 5.07 1.01E‐04 LAMP1 lysosomal‐associated membrane protein 1 3916 5.06 1.15E‐03

AQP3 (Gill blood group) 360 5.04 1.21E‐03 TMEM49 transmembrane protein 49 81671 5.03 2.08E‐03 SFXN4 sideroflexin 4 119559 5.03 6.57E‐06 Type Symbol Description GeneID Ratio P‐value FAM114A1 family with sequence similarity 114, member 92689 5.02 1.27E‐05 A1 SPATA6 spermatogenesis associated 6 54558 4.99 4.69E‐04 SEZ6L seizure related 6 homolog (mouse)‐like 23544 4.98 3.84E‐04

GLIPR1 GLI pathogenesis‐related 1 11010 4.96 2.40E‐03 MGC3196 hypothetical protein MGC3196 79064 4.95 5.61E‐03 TRAM2 translocation associated membrane protein 9697 4.94 1.05E‐03 2 SDC1 syndecan 1 6382 4.90 1.65E‐03 GLIPR2 GLI pathogenesis‐related 2 152007 4.86 8.80E‐04 C3orf52 open reading frame 52 79669 4.82 2.08E‐04 PCF11 PCF11p homolog 51585 4.80 4.19E‐04 VAMP3 vesicle‐associated membrane protein 3 9341 4.79 1.11E‐05 (cellubrevin) NDE1 nudE nuclear distribution gene E homolog 1 54820 4.77 4.18E‐04 (A. nidulans) SAMD9L sterile alpha motif domain containing 9‐like 219285 4.75 1.90E‐04

KCTD1 potassium channel tetramerisation domain 284252 4.73 6.81E‐04 containing 1 TMEM154 transmembrane protein 154 201799 4.69 1.25E‐03 C7orf38 open reading frame 38 221786 4.69 6.75E‐03 LOC344595 hypothetical LOC344595 344595 4.68 4.26E‐04 TSPAN12 transmembrane 4 superfamily member 12 23554 4.67 3.93E‐03

TMTC1 transmembrane and tetratricopeptide 83857 4.65 4.26E‐03 repeat containing 1 DPH3 DPH3, KTI11 homolog (S. cerevisiae) 285381 4.63 1.58E‐05 LRRC3B leucine rich repeat containing 3B 116135 4.62 5.48E‐05 SIPA1L1 signal‐induced proliferation‐associated 1 like 26037 4.57 1.22E‐03 1 BCL9 B‐cell CLL/lymphoma 9 607 4.55 1.86E‐03 TTC39B tetratricopeptide repeat domain 39B 158219 4.54 2.41E‐04 IKIP IKK interacting protein 121457 4.53 1.57E‐04 TRAF3IP2 TRAF3 interacting protein 2 10758 4.53 2.54E‐02 SCFD2 sec1 family domain containing 2 152579 4.52 1.01E‐04 C1orf97 open reading frame 97 84791 4.46 3.45E‐03 C1orf226 chromosome 1 open reading frame 226 400793 4.44 2.05E‐03 GSN gelsolin (amyloidosis, Finnish type) 2934 4.44 7.14E‐04 C1orf85 chromosome 1 open reading frame 85 112770 4.43 4.70E‐03 LOC652164 similar to KIAA0454 protein 652164 4.43 1.98E‐04 IFITM3 interferon induced transmembrane protein 3 10410 4.42 8.08E‐03 (1‐8U) SLC2A3 solute carrier family 2 (facilitated 6515 4.40 4.86E‐04 transporter), member 3 LOC401317 hypothetical LOC401317 401317 4.38 1.33E‐04 FAM171B family with sequence similarity 171, member 165215 4.35 3.12E‐08 B GRB10 growth factor receptor‐bound protein 10 2887 4.31 4.76E‐04

LOC389641 hypothetical gene supported by AK124295 389641 4.31 3.93E‐03

SC65 synaptonemal complex protein SC65 10609 4.31 1.56E‐03 Type Symbol Description GeneID Ratio P‐value CCND1 cyclin D1 (PRAD1: parathyroid adenomatosis 595 4.31 3.87E‐02 1) HCG22 HLA complex group 22 285834 4.29 7.29E‐03 SRPX sushi‐repeat‐containing protein, X 8406 4.23 1.40E‐04 chromosome FAM162A family with sequence similarity 162, member 26355 4.23 1.62E‐02 A SLC7A11 solute carrier family 7, (cationic 23657 4.22 4.85E‐03 transporter, y+ system) member 11

LMNA lamin A/C 4000 4.21 7.13E‐05 SLC35F5 solute carrier family 35, member F5 80255 4.20 2.10E‐03 LARP6 La ribonucleoprotein domain family, 55323 4.19 5.71E‐03 member 6 TTC17 tetratricopeptide repeat domain 17 55761 4.18 8.23E‐05 EPSTI1 epithelial stromal interaction 1 (breast) 94240 4.18 4.10E‐03 RIT1 Ras‐like without CAAX 1 6016 4.17 7.60E‐04 CPNE8 copine VIII 144402 4.15 1.64E‐04 C15orf37 chromosome 15 open reading frame 37 283687 4.13 5.81E‐04 LOC346887 similar to solute carrier family 16 346887 4.12 1.04E‐04 (monocarboxylic acid transporters), member 14 SLC30A1 solute carrier family 30 (zinc transporter), 7779 4.12 1.98E‐04 member 1 NUPR1 nuclear protein 1 26471 4.11 5.37E‐04 IFITM2 interferon induced transmembrane protein 2 10581 4.11 7.28E‐03 (1‐8D) SLC25A13 solute carrier family 25, member 13 (citrin) 10165 4.10 2.22E‐03

NPC2 Niemann‐Pick disease, type C2 10577 4.10 5.86E‐04 ADFP adipose differentiation‐related protein 123 4.09 3.46E‐05 NACC2 NACC family member 2, BEN and BTB (POZ) 138151 4.07 3.72E‐05 domain containing HIST2H2AA4 histone cluster 2, H2aa4 723790 4.07 1.04E‐03 TMEM101 transmembrane protein 101 84336 4.03 1.35E‐04 PAG1 phosphoprotein associated with 55824 4.03 3.98E‐04 microdomains 1 YIPF6 Yip1 domain family, member 6 286451 4.03 1.65E‐04 KIAA0644 KIAA0644 gene product 9865 4.01 7.44E‐03 HIST1H2BI histone cluster 1, H2bi 8346 4.00 2.35E‐03 F3 coagulation factor III, TF 2152 4.00 3.28E‐03