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University of Bradford Ethesis
University of Bradford eThesis This thesis is hosted in Bradford Scholars – The University of Bradford Open Access repository. Visit the repository for full metadata or to contact the repository team © University of Bradford. This work is licenced for reuse under a Creative Commons Licence. THE ROLE OF BONE MORPHOGENETIC PROTEIN SIGNALLING IN THE CONTROL OF SKIN REPAIR AFTER WOUNDING Cellular and molecular mechanisms of cutaneous wound healing mediated by bone morphogenetic proteins and their antagonist Noggin Christopher John LEWIS Submitted for the degree of Doctor of Philosophy Medical Biosciences School of Life Sciences University of Bradford 2013 Abstract The role of bone morphogenetic protein signalling in the control of skin repair after wounding. Christopher John LEWIS Keywords: Wound healing, bone morphogenetic protein, BMP, skin, keratinocyte, Noggin, Smad Bone morphogenetic proteins (BMPs) and their receptors (BMPRs) coordinate tissue development and postnatal remodelling by regulating proliferation, differentiation and apoptosis. However, their role in wound healing remains unclear. To study this, transgenic mice overexpressing Smad1 (K14-caSmad1) or the BMP antagonist Noggin (K14-Noggin) were utilised, together with human and mouse ex vivo wound healing models and in vitro keratinocyte culture. In wild-type mice, transcripts for Bmpr-1A, Bmpr-II, Bmp ligands and Smad proteins were decreased following tissue injury, whilst Bmpr-1B expression was up-regulated. Furthermore, immunohistochemistry revealed a down-regulation of BMPR-1A in hair follicles adjacent to the wound in murine skin, whilst in murine and human wounds, BMPR-1B and phospho-Smad-1/5/8 expression was pronounced in the wound epithelial tongue. K14-caSmad1 mice displayed retarded wound healing, associated with reduced keratinocyte proliferation and increased apoptosis, whilst K14-Noggin mice exhibited accelerated wound healing. -
KPDA Media Weekly Review Report As at 14 2021
KPDA Media Weekly Review Report as at 14th May 2021 CEO DE-BRIEF 2021 UN-HABITAT SCROLL OF HONOUR CALL FOR NOMINATIONS The UN-Habitat Scroll of Honour Award was launched in 1989 and is one of the most prestigious human settlements awards. The award acknowledges initiatives which have made outstanding contributions in the field of Human Settlements, Provision of affordable, accessible and adequate housing, developing and improving human settlements and the quality of urban life to leave no one behind. Nominations guidelines for the award can be accessed at https://unhabitat.org/sites/default/files/2021/04/scroll-of-honour-guidelines-2021.pdf and https://unhabitat.org/call-for-nominations-of-the-2021-scroll-of-honour. Take note that the deadline for receiving nominations via the online form is Sunday, 8th August 2021. OPEN FOR APPLICATION! PUBLIC SECTOR INNOVATION PROGRAMME "INNOVATION FOR CHANGE IN PUBLIC TRANSPORT" AT LUND UNIVERSITY, SWEDEN Lund University has proudly opened the application process for the second edition of Public Sector Innovation programme Innovation for Change in Public Transport. The programme is carried out with financial support from the Swedish Institute (SI). This year, the programme targets international professionals from Kenya, Nigeria, South Africa and Uganda and contributes to innovation in the public sector and support the implementation of the 2030 Agenda for sustainable development. The programme aims to empower individuals representing the actors in public as well as private organizations so that they can work together for a renewal of public transport systems and thereby contribute to sustainable cities and communities. Take the opportunity and apply for the programme here. -
The Entrepreneur's Guide to Doing Business in the Music Industry
THE ENTREPRENEUR’S GUIDE TO DOING BUSINESS IN THE MUSIC INDUSTRY by Gian Fiero Copyright 2005 by Gian Fiero All rights reserved. No part of this guide may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing by the author. ii iii Acknowledgements To all of my clients and the artists I’ve represented over the past 10 years: Thanks for choosing me when you have so many choices. I never forget that your trust in me is more valuable than any service I could ever offer. To my associates in Northern & Southern California: Thanks for the inspiration, encouragement, and support. iv v TABLE OF CONTENTS The Purpose of This Guide ...................................................................................... 1 Definition & Overview of This Guide....................................................................... 5 The Real Cash Cows of the Music Industry .........................................................11 Advice for the Potential Record Label Owner.......................................................15 Advice for Music Producers ...................................................................................19 Playing a Different Tune as a Music Artist ..........................................................23 Taking the Right Angle to Get a Deal ...................................................................29 Approaching Investors ...........................................................................................33 -
Kidero's Time to ·Deliver After Petition Dismissed Judges Say the Joined Other Jubilant Support- Ers in Relishing the Verdict
SATURDAY NATION 8 I National News August 30, 2014 ( '-!to' COURTS I Election dispute had dragged on for 18months .THE BRIGHT AND BEAUTIFUL IWe'vemade it! Kidero's time to ·deliver after petition dismissed Judges say the joined other jubilant support- ers in relishing the verdict. Court of Appeal Dr Kidero said the petition had been a distraction for the entertained an 18 months it lasted. incompetent appeal "The moment for delivery of my pre-election promises to Nairobi residents has finally BY VINCENT AGOYA dawned," he said outside the @1"O}'agoya court. [email protected] Mr Waititu was also in court, but conspicuously alone. This airobi Governor was in stark contrast to earlier JENNIFER MUlRURl1 NATION' Evans Kidero can now proceedings that culminated Froin right, Ms Claris Leparkiras, Ms Lennah Nyanchama, Mr Mercy Njeri and Ms Elizabeth Yimba- N breathe easy and serve in the nullification of Dr Ki- ine during the 51st graduation at the University .of Nairobi yesterday. They were conferred with city residents with undivided dero's victory at the Court of . Bachelors of Science degrees in Wildlife Management and Conservation. attention after the Supreme' Appeal when he used to be Court reaffirmed his election escorted by Nairobi Senator yesterday. Mike Sonko and a crowd of The court set aside a ruling chanting supporters. made by two appellate judges Yesterday. it was Dr Kidero Why youth join terror gangs which had invalidated the vic- and the ODM supporters who tory of Dr Kidero and Deputy thronged the streets of the BY NATION REPORTER more rigorous action in dealing liances all over the world and Governor Jonathan Mueke. -
Manifesto 2030 Advocacy Hub Report
Streets for Life Love30 SAFE AND HEALTHY STREETS FOR CHILDREN, YOUTH AND CLIMATE ADVOCACY HUB SUPPORT STREETS FOR LIFE Road traffic crashes are the leading cause of death At the heart of the 2020 Stockholm Declaration for children and young adults. We need a new for Global Road Safety was a call for 30 kilometre SUPPORT STREETS FOR LIFE... vision for creating safe, healthy, green and liveable cities. an hour speed limits on urban streets. Why? Because Low speed streets are an important part of that vision. we know that above 30 the risk of death for pedestrians Evidence shows that limiting driving speeds rises exponentially. So, it is a simple equation. If you to 30km/h or 20mph in cities significantly support Vision Zero, if you believe that no one should reduces road traffic deaths and injuries. As die or be maimed in a road we recover and rebuild from COVID-19, crash, then you must ‘love 30’. let’s make safer roads for a safer world. Rt. Hon. Lord Robertson of Port Ellen Dr Tedros Adhanom Chairman, FIA Ghebreyesus Foundation Director General, World Health Organization Implementing 30km/h in streets with mixed traffic, So many of us around the world are taking to and where children live, walk and play, is life-saving. the streets and demanding change. The streets Lower speeds can encourage more walking and cycling are for the people. We want low speeds, we want and help us shift to zero carbon mobility. Streets for Life liveable streets, and communities where Streets for Life contribute to achieving Love30 we can walk safely, where our children many of our Sustainable can get to school unharmed. -
Commencement Program
Sunday, the Sixteenth of May, Two Thousand and Ten ten o’clock in the morning ~ wallace wade stadium Duke University Commencement ~ 2010 One Hundred Fifty-Eighth Commencement Notes on Academic Dress Academic dress had its origin in the Middle Ages. When the European universities were taking form in the thirteenth and fourteenth centuries, scholars were also clerics, and they adopted Mace and Chain of Office robes similar to those of their monastic orders. Caps were a necessity in drafty buildings, and Again at commencement, ceremonial use is copes or capes with hoods attached were made of two important insignia given to Duke needed for warmth. As the control of universities University in memory of Benjamin N. Duke. gradually passed from the church, academic Both the mace and chain of office are the gifts costume began to take on brighter hues and to of anonymous donors and of the Mary Duke employ varied patterns in cut and color of gown Biddle Foundation. They were designed and and type of headdress. executed by Professor Kurt J. Matzdorf of New The use of academic costume in the United Paltz, New York, and were dedicated and first States has been continuous since Colonial times, used at the inaugural ceremonies of President but a clear protocol did not emerge until an Sanford in 1970. intercollegiate commission in 1893 recommended The Mace, the symbol of authority of the a uniform code. In this country, the design of a University, is made of sterling silver throughout. gown varies with the degree held. The bachelor’s Significance of Colors It is thirty-seven inches long and weighs about gown is relatively simple with long pointed Colors indicating fields of eight pounds. -
Mrs. Amina Mohamed Cabinet Secretary of Education Kenya Email
Mrs. Amina Mohamed Cabinet Secretary of Education Kenya Email: [email protected] File Reference: RP/SV Contact: [email protected] 21 May 2018 Your Excellency, LACK OF SOCIAL DIALOGUE IN KENYA Public Services International (PSI) brings together more than 20 million workers, represented by over 700 unions in 163 countries and territories. We are a global trade union federation dedicated to promoting quality public services in every part of the world. Our members, two-thirds of whom are women, work in social services, health care, municipal and community services, central government, and public utilities such as water, electricity and education. PSI observes a worrying trend in Kenya in relation to the Government’s capacity to encourage industrial democracy, harmony and declining to address emerging industrial issues raised by unions. In February 2017, we already addressed a letter to the Cabinet of Health in relation to the doctors’ and nurses’ strike. On Friday 2nd March 2018, the Kenya Universities Staff Union (KUSU), called its members to withdraw labour in a national strike against the government and 31 public university managements for failing to negotiate collective bargaining covering the 2017-2021 cycle. This is the result of months of fruitless meetings without any concrete outcome. We further observe that the Government of Kenya, through its various agencies, has not availed of the instruments put in place by labour legislation to amicably address and improve emerging union concerns before they snowball into a crisis. It is important to note that long strikes are not only detrimental to harmonious working relations but also for the economy at large. -
Egypt Education Legacy 35 Years of a Partnership in Education
EGYPT EDUCATION LEGACY 35 YEARS OF A PARTNERSHIP IN EDUCATION January 2012 This report was produced for review by the United States Agency for International Development, Mission to Egypt (USAID/Egypt), under a task order of the Global Evaluation and Monitoring (GEM II) IQC, Contract No. EDH-E-23-08- 00003-00. It was prepared by the Aguirre Division of JBS International, Inc. Cover page photo by GILO project EGYPT EDUCATION LEGACY January 2012 The authors’ views expressed in this publication do not necessarily reflect the views of the United States Agency for International Development or the United States Government. This document is available in printed and online versions. The online version is stored at the Development Experience Clearinghouse (http://dec.usaid.gov). Additional information can be obtained from [email protected]. ACKNOWLEDGMENTS The U.S. Agency for International Development (USAID) would like to express sincere gratitude to the many institutions and people who have made the 35-year partnership in Egypt’s education sector so fruitful. The education system has benefited from the valuable collaboration of many Egyptian officials and policy makers. First, we would like to express our sincere gratitude to the Government of Egypt, primarily the Ministry of Education. Several officials have led this office over the years, and we acknowledge each and every one of them. We are also grateful to staff in departments and units at the central, governorate (Muddiraya), district (Idara), and school levels. Success in the sector is due largely to the support and sincere cooperation of all these key actors. USAID would especially like to thank Dr. -
Position Description
Position Description Position Title: Business Manager Reports to: Chief Executive Officer Position Status: Full Time (Contract) Location: 95 Drummond Street, Carlton, VIC. 3053 ABOUT PENINGTON INSTITUTE Penington Institute advances health and community safety by connecting substance use research to practical action. Our activities: Enhance awareness of the health, social and economic drivers of drug-related harm. Promote rational, integrated approaches to reduce the burden of death, disease and social problems related to problematic substance use. Build and share knowledge to empower individuals, families and the community to take charge of substance use issues. Better equip front-line workers to respond effectively to the needs of those with problematic drug use. Our purpose is framed by our knowledge that we need to look at more effective, cost-efficient and compassionate ways to prevent and respond to problematic drug use in our community. Penington Institute acknowledges the importance of individual responsibility in relation to substance use, as well as the role of government and community to address the risks that contribute to problematic use of licit and illicit drugs and alcohol. Penington Institute is a non-partisan, registered charitable organisation. Our values Productivity: We support actions that deliver the best health, social and economic returns. Integrity: Drug use is a complex issue. We advocate fair, evidence-based systems that improve the health and wellbeing of individuals, families and communities. Compassion: We do not condone drug use, but work to protect people from drug-related harm when at their most vulnerable. Feasible and accessible options are needed to help reduce the risks associated with the use of different types of drugs, including pharmaceuticals, alcohol and nicotine. -
Kenya Deputy President William Ruto 2021
Meet the Real William Ruto MPs and other Mt Kenya politicians who insist they do not have a problem with President Uhuru Kenyatta, that their differences with Uhuru is because of Raila Odinga, or because they suspect Uhuru is not willing to support DP William Ruto for presidency in 2022, are either naive, or outright liars. WILLIAM RUTO WITH FAROUK KIBET During the weekend of December 8 - 9, 2019, DP Ruto attended events in at least 5 counties, including: 1. The African Independent Pentecostal Church of Africa (AIPCA), Mukaro Diocese, Giakanja, Nyeri County. 2. Anglican Church of Kenya (ACK) Cathedral of St Peter’s Mbeere, Siakago, Embu County. 3. St. Francis of Assisi Catholic Church, Mukuyuni, Makueni County. 4. Ndagani Catholic Parish, Chuka, Tharaka-Nithi County. 5. Presbyterian Church of East Africa (PCEA), Kipipiri, Nyandarua County. Every politically enlightened Kenyan knows what these events represent. They could be termed prayer-worship, fundraising or whatever. But we know they are also campaign events, and have been going on for almost 2 years now. In fact, I don’t think any other Kenyan has ever spent so much time airborne, on Kenyan airspace, as DP Ruto has (apart from pilots & air hostesses). This is what I believe is going on: A little digression: Once upon a time, I worked for 3 months as a clerk in a government office. One day, I accompanied my boss as he went to buy some equipment in town. That was when I learnt why corruption is so prevalent in Kenya. The business itself encouraged corruption, probably so that one can become a frequent customer. -
SPEC Barometer, 2Nd QTR 2018 First Media Release
SPEC Barometer, 2nd QTR 2018 First Media Release PREPARED BY: IPSOS PREPARED FOR: GENERAL MEDIA RELEASE RELEASE DATE: 22 AUGUST 2018 © 2018 Ipsos. All rights reserved. Contains Ipsos' Confidential and Proprietary information and may not be disclosed or reproduced without the prior written consent of Ipsos. 1 © 2018 Ipsos. Contents 01 Methodology 02 Demographics + Recent Events Awareness of Recent Corruption Most Serious Problem in Kenya: 04 Scandals and Perceived Associated 03 Corruption Trend Analysis Individuals Perceived Most Corrupt Past and President’s Perceived Commitment to Current Leaders, Expectations of 06 Fighting Corruption and Expectations of 05 Convictions Success Perceived Main Impediments to Belief that a Corrupt Person Can Be a 07 Reducing Corruption/Suggested 08 Good Leader Measures to More Effectively Combat It Expectations for Criminal Accountability: 09 “Big People” vs. “People Like Me” 10 Kenya’s Direction and Reasons 2 © 2018 Ipsos. METHODOLOGY 33 © 2018 Ipsos. Methodology Dates of Fieldwork 25TH July– 2nd August, 2018 Sample Size 2,016 (Total Individual Contacts: 3, 484) Random, Multi-stage stratified using PPS (proportionate Sampling Methodology to population size) Spread across 46 counties Kenyan adults, aged 18 and above living in Urban and Population Universe Rural areas Data Collection Face-to-Face interviews at the household level Methodology +/-2.16% with a 95% confidence level Sampling Error (Note: Higher error-margins for sub-samples) Interview Languages English, Swahili, Somali 4 © 2018 Ipsos. Sample Structure Statistics: Across 46 Counties Population Census of % Sample Frame statistics % Region (July 2018) 2009 Of *Weighted data of Sample Adults (18 years +) Population Central 268 13 2,548,038 13 Coast 174 9 1,711,549 9 Eastern 303 15 2,907,293 15 Nairobi 214 11 2,042,770 10 North Eastern 98 5 929,158 5 Nyanza 262 13 2,547,980 13 Rift Valley 496 25 4,795,482 25 Western 203 10 1,980,090 10 5 © 2018 Ipsos. -
Zambia, 9-10 May 2006
International Labour Office People with Disabilities: Pathways to Decent Work REPORT OF A TRIPARTITE WORKSHOP Lusaka, Zambia, 9-10 May 2006 Organized by the ILO Skills and Employability Department Funded by the Government of Flanders and the Government of Ireland Copyright © International Labour Organization 2007 Publications of the International Labour Office enjoy copyright under Protocol 2 of the Universal Copyright Convention. Nevertheless, short excerpts from them may be reproduced without authorization, on condition that the source is indicated. For rights of reproduction or translation, application should be made to the ILO Publications (Rights and Permissions), International Labour Office, CH-1211 Geneva 22, Switzerland, or by email: [email protected]. The International Labour Office welcomes such applications. Libraries, institutions and other users registered in the United Kingdom with the Copyright Licensing Agency, 90 Tottenham Court Road, London W1T 4LP [Fax: (+44) (0)20 7631 5500; email: [email protected]], in the United States with the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923 [Fax: (+1) (978) 750 4470; email: [email protected]] or in other countries with associated Reproduction Rights Organizations, may make photocopies in accordance with the licences issued to them for this purpose. ILO People with disabilities: Pathways to decent work: Report of a tripartite workshop, Lusaka, Zambia, 9-10 May 2006 / organized by the ILO Skills and Employability Department. -- Geneva : ILO, 2007 – ca. 51p. ISBN: 9789221195429;