Neurologic Emergencies

Each year in the United States, an estimated 2.8 million people sustain a traumatic brain (TBI) 1, 795,000 suffer a stroke 2, and approximately 17,700 sustain a (SCI) 3.

Acute neurologic are among the most difficult injuries to treat. Even when they aren’t fatal, the ability to recover from them is limited.

Traumatic Brain Injury Stroke Spinal Cord Injury A disruption in the normal function When blood flow from an artery When the spinal cord is affected of the brain caused by a blow or supplying the brain is stopped by by an accident or other situation jolt to the head, an explosive blast, a blockage, resulting in the loss of leaving it partially or permanently or from a penetrating . function in areas controlled by that damaged. Depending on the level Can be lethal, result in coma, and/ region of the brain. Another major of the injury, this can result in or leave victims with permanent type of stroke occurs when the wall partial or complete paralysis of the severe disabilities based on the of an artery in the brain breaks, limbs as well as varying degrees of region of brain that is injured. causing blood to leak out. respiratory difficulty.

Sources Taylor CA, Bell JM, Breiding MJ, Xu L. –Related Emergency Department Visits, Hospitalizations, and Deaths— United States, 2007 and 2013. MMWR Surveill Summ 2017;66(No. SS-9):1–16. DOI: http://dx.doi.org/10.15585/mmwr.ss6609a1 Benjamin EJ, Blaha MJ, Chiuve SE, et al. on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2017 update: a report from the American Heart Association. Circulation. 2017;135:e229-e445. N.-H. White, N.-H. Black Spinal Cord Injury Facts and Figures at a GlanceNational Spinal Cord Injury Statistical CenterUniversity of Alabama at Birmingham, Birmingham, AL (2017) "Our family’s investment in Michigan Medicine through MCIRCC was an investment in the lives of millions of patients around the world who are impacted by TBI every day. Together, we are creating a brighter future for emergency and critical care through bold research, unparalleled education, and exceptional patient care." —Brenda Massey, President The Joyce & Don Massey Family Foundation

The MCIRCC Solution At MCIRCC, we are developing diagnostics, monitors and therapeutics for patients who suffer acute neurologic catastrophes such as traumatic brain injury, stroke, and spinal cord injury. To accelerate the movement of translational research outputs into the field, we partner with organizations such as the Joyce and Don Massey Family Foundation and the United States Department of Defense.

Sample MCIRCC innovations addressing neurologic emergencies include:

MitoLUX Barreleye Microfluidic Testing Device During a brain injury, blood flow Barreleye (named after the Proteins and other unique to the brain is often restricted. unique fish with a transparent biomarkers can be found in the When the blood flow is restored, head) non-invasively collects blood that leaks out of the brain toxic free radicals are generated physiological data and calculates during a brain injury. MCIRCC is and can cause cell damage. The clinically-relevant measures to developing a microfluidic device MitoLUX helmet uses infrared gauge trajectory and predict that will allow for the bedside light (IRL) to modulate the brain's potential adverse events for detection of these biomarkers, mitochondria to prevent the patients with injuries such as gving care providers a timing generation of these free radicals. TBI and stroke. advantage in the diagnosis and treatment of these injuries.

For more information

[email protected] (734) 647-4751 mcircc.umich.edu/research-area-neurologic