Supplemental Table 1: induced by L1-CAM in Ls174T human colon cancer cells

Gene Fold

Symbol Description Increase

Group1: Cellular , (steroid/sterol, xenobiotic, carboxylic acid, isoprenoid, coenzyme metabolism)

SLC3A1 solute carrier family 3 3.98

FDX1 ferredoxin 1 3.93

GLS2 glutaminase 2 (liver, mitochondrial) 3.45

IDI1 isopentenyl-diphosphate delta 1 3.10

ENO2 enolase 2 (gamma, neuronal) 2.87

MVD mevalonate (diphospho) decarboxylase 2.81

ACOT7 acyl-CoA 7 2.70

LSS lanosterol synthase 2.55

ABAT 4-aminobutyrate aminotransferase 2.55

MVK mevalonate (mevalonic aciduria) 2.49

FDPS farnesyl diphosphate synthase 2.48

LDLRAP1 low density lipoprotein receptor adaptor 1 2.44

ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) 2.43

SQLE squalene epoxidase 2.35

PLA2G4A A2, group IVA 2.34

FADS1 fatty acid desaturase 1 2.31 UGT1A UDP glucuronosyltransferase 1 family 2.25

FDXR ferredoxin reductase 2.24

AKR1C1 aldo-keto reductase family 1, member C1 2.10

FADS2 fatty acid desaturase 2 2.08

EBP emopamil binding protein (sterol isomerase) 2.00

AKR1C2 aldo-keto reductase family 1, member C2 1.90

DHFR dihydrofolate reductase 1.88

NQO1 NAD(P)H dehydrogenase, quinone 1 1.72

OXCT1 3-oxoacid CoA 1 1.71

AKR1C3 aldo-keto reductase family 1, member C3 1.62

FASN fatty acid synthase 1.58

PGM1 phosphoglucomutase 1 1.51

Group2: Negative regulation of programmed cell death

SOCS2 suppressor of cytokine signaling 2 4.77

HSPA1A/B heat shock 70kDa protein 1A/protein 1B 3.14

HSPB1 heat shock 27kDa protein 1 2.23

TPT1 tumor protein, translationally-controlled 1 2.01

ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 1.88

ANXA4 annexin A4 1.68

Group 3: DNA metabolism

POLD1 (DNA directed), delta 1 3.14

NASP nuclear autoantigenic sperm protein (histone-binding) 2.69

Pfs2 DNA replication complex GINS protein PSF2 2.32

DFFB DNA fragmentation factor, 40kDa, beta polypeptide 2.28

IGFBP4 insulin-like growth factor binding protein 4 2.15

UNG -DNA glycosylase 2.07

RNASEH2A H2, large subunit 1.91

GLRX2 glutaredoxin 2 1.89

RAD54L RAD54-like (S. cerevisiae) 1.70

HMGA1 high mobility group AT-hook 1 1.15

Group 4: Intracellular transport, cytoskeleton organization and biogenesis

TUBAL3 tubulin, alpha-like 3 3.02

HOMER3 homer homolog 3 (Drosophila) 2.80

TUBA2 tubulin, alpha 2 2.72

TUBB2PARA tubulin, beta 2 / tubulin, beta polypeptide paralog 2.60

TUBB3 tubulin, beta 3 2.59

TUBA1 tubulin, alpha 1 2.32

TUBG1 tubulin, gamma 1 2.23

TUBB tubulin, beta polypeptide 2.08

PLEK2 pleckstrin 2 2.01

DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 1.97 TUBB2 tubulin, beta 2 1.56

HSP90AA1 heat shock protein 90kDa alpha 1.43

TUBA6 tubulin, alpha 6 1.10

Group 5: Cellular protein metabolism

DPP4 dipeptidylpeptidase 4 6.94

PTPRR protein tyrosine , receptor type, R 5.88

DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 3.59

FAP fibroblast activation protein, alpha 2.84

MVK (mevalonic aciduria) 2.49

LRP8 low density lipoprotein receptor-related protein 8, 2.47

MAPKAPK3 mitogen-activated -activated protein kinase 2.47

PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.43

ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) 2.43

DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.25

CACYBP calcyclin binding protein 2.22

HSPA8 heat shock 70kDa protein 8 2.21

CAPN9 calpain 9 2.13

TCP1 t-complex 1 2.11

YBX2 Y box binding protein 2 2.01

F12 coagulation factor XII (Hageman factor) 1.99

HSPE1 heat shock 10kDa protein 1 1.96

DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 1.87 TFRC transferrin receptor (p90, CD71) 1.60

Group 6: Other Genes

HBA1/2 hemoglobin, alpha 1/2 28.63

C9orf26 9 open reading frame 26 (NF-HEV) 15.70

CLIC5 chloride intracellular channel 5 14.11

ITM2A integral membrane protein 2A 12.90

MAOA monoamine oxidase A 6.19

CRIP1 cysteine-rich protein 1 (intestinal) 5.92

FGFBP1 fibroblast growth factor binding protein 1 5.67

IFI16 , gamma-inducible protein 16 5.23

ALDH3A1 aldehyde dehydrogenase 3 family, memberA1 5.20

CALB2 calbindin 2, 29kDa (calretinin) 4.23

INSIG1 insulin induced gene 1 3.97

DKFZP564O0823 DKFZP564O0823 protein 3.60

KITLG KIT ligand 3.54

PLLP plasma membrane proteolipid (plasmolipin) 3.45

PSTPIP2 proline-serine-threonine phosphatase 3.42

TPM2 tropomyosin 2 (beta) 3.40

FXYD3 FXYD domain containing ion transport regulator 3 3.36

PSD3 pleckstrin and Sec7 domain containing 3 3.28

GOLPH2 golgi phosphoprotein 2 3.23

PTMA prothymosin, alpha 3.16 MTCP1 mature T-cell proliferation 1 2.98

RABIF RAB interacting factor 2.98

CKB , brain 2.94

SEMA3C semaphorin 3C 2.85

SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 2.82

SLC6A20 solute carrier family 6 2.80

PROCR protein C receptor, endothelial (EPCR) 2.80

TSPAN1 tetraspanin 1 2.72

C1orf121 open reading frame 121 2.67

SLC1A1 solute carrier family 1 2.61

MICB MHC class I polypeptide-related sequence B 2.60

NPAS2 neuronal PAS domain protein 2 2.53

ABHD6 abhydrolase domain containing 6 2.50

SWAP70 SWAP-70 protein 2.49

ELOVL6 ELOVL family member 6 2.48

STIP1 stress-induced-phosphoprotein 1 2.47

CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 2.46

STEAP3 STEAP family member 3 2.46

MLSTD1 male sterility domain containing 1 2.44

UAP1L1 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 2.43

NAV3 neuron navigator 3 2.39

VAT1 vesicle amine transport protein 1 homolog 2.33

NDRG2 NDRG family member 2 2.29 DCC1 defective in sister chromatid cohesion homolog 1 2.27

PARVB parvin, beta 2.25

MAK3 N-acetyltransferase 13 2.18

SPBC25 spindle body component 25 homolog 2.17

ENDOD1 domain containing 1 2.16

MFGE8 milk fat globule-EGF factor 8 protein 2.14

CCDC69 coiled-coil domain containing 69 2.08

SPAG9 sperm associated antigen 9 2.04

TMEM97 transmembrane protein 97 2.04

FABP5 fatty acid binding protein 5 (psoriasis-associated) 2.03

FLJ20647 hypothetical protein FLJ20647 1.96

C20orf27 open reading frame 27 1.95

TRPM2 transient receptor potential cation channel 1.95

STRA13 stimulated by retinoic acid 13 homolog 1.93

CEACAM6 carcinoembryonic antigen-related cell adhesion 6 1.92

PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 1.88

C4orf18 chromosome 4 open reading frame 18 1.88

CKMT1A/B creatine kinase, mitochondrial 1A/1B 1.84

TRIP13 thyroid hormone receptor interactor 13 1.81

SLC29A1 solute carrier family 29, member 1 1.79

RHOT2 ras homolog gene family, member T2 1.79

S100A6 S100 calcium binding protein A6 (calcyclin) 1.78

ATP10A ATPase, Class V, type 10A 1.77 DBI diazepam binding inhibitor 1.74

BRRN1 non-SMC condensin I complex, subunit H 1.73

CCNA2 cyclin A2 1.71

HSPC176 hematopoietic stem/progenitor cells 176 1.71

IFI30 interferon, gamma-inducible protein 30 1.70

MVP major vault protein 1.67

LRRC19 leucine rich repeat containing 19 1.54

LGALS3 lectin, galactoside-binding, soluble, 3 1.50

MSN moesin 0.96

PIGR polymeric immunoglobulin receptor 0.64

*Highlighted genes (in yellow) are upregulated in both Ls174T L1-CAM transfected cells and in human colon carcinoma tissue samples.