Supplemental Table 1: Genes induced by L1-CAM in Ls174T human colon cancer cells
Gene Gene Fold
Symbol Description Increase
Group1: Cellular lipid metabolism, (steroid/sterol, xenobiotic, carboxylic acid, isoprenoid, coenzyme metabolism)
SLC3A1 solute carrier family 3 3.98
FDX1 ferredoxin 1 3.93
GLS2 glutaminase 2 (liver, mitochondrial) 3.45
IDI1 isopentenyl-diphosphate delta isomerase 1 3.10
ENO2 enolase 2 (gamma, neuronal) 2.87
MVD mevalonate (diphospho) decarboxylase 2.81
ACOT7 acyl-CoA thioesterase 7 2.70
LSS lanosterol synthase 2.55
ABAT 4-aminobutyrate aminotransferase 2.55
MVK mevalonate kinase (mevalonic aciduria) 2.49
FDPS farnesyl diphosphate synthase 2.48
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.44
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) 2.43
SQLE squalene epoxidase 2.35
PLA2G4A phospholipase A2, group IVA 2.34
FADS1 fatty acid desaturase 1 2.31 UGT1A UDP glucuronosyltransferase 1 family 2.25
FDXR ferredoxin reductase 2.24
AKR1C1 aldo-keto reductase family 1, member C1 2.10
FADS2 fatty acid desaturase 2 2.08
EBP emopamil binding protein (sterol isomerase) 2.00
AKR1C2 aldo-keto reductase family 1, member C2 1.90
DHFR dihydrofolate reductase 1.88
NQO1 NAD(P)H dehydrogenase, quinone 1 1.72
OXCT1 3-oxoacid CoA transferase 1 1.71
AKR1C3 aldo-keto reductase family 1, member C3 1.62
FASN fatty acid synthase 1.58
PGM1 phosphoglucomutase 1 1.51
Group2: Negative regulation of programmed cell death
SOCS2 suppressor of cytokine signaling 2 4.77
HSPA1A/B heat shock 70kDa protein 1A/protein 1B 3.14
HSPB1 heat shock 27kDa protein 1 2.23
TPT1 tumor protein, translationally-controlled 1 2.01
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 1.88
ANXA4 annexin A4 1.68
Group 3: DNA metabolism
POLD1 polymerase (DNA directed), delta 1 3.14
NASP nuclear autoantigenic sperm protein (histone-binding) 2.69
Pfs2 DNA replication complex GINS protein PSF2 2.32
DFFB DNA fragmentation factor, 40kDa, beta polypeptide 2.28
IGFBP4 insulin-like growth factor binding protein 4 2.15
UNG uracil-DNA glycosylase 2.07
RNASEH2A ribonuclease H2, large subunit 1.91
GLRX2 glutaredoxin 2 1.89
RAD54L RAD54-like (S. cerevisiae) 1.70
HMGA1 high mobility group AT-hook 1 1.15
Group 4: Intracellular transport, cytoskeleton organization and biogenesis
TUBAL3 tubulin, alpha-like 3 3.02
HOMER3 homer homolog 3 (Drosophila) 2.80
TUBA2 tubulin, alpha 2 2.72
TUBB2PARA tubulin, beta 2 / tubulin, beta polypeptide paralog 2.60
TUBB3 tubulin, beta 3 2.59
TUBA1 tubulin, alpha 1 2.32
TUBG1 tubulin, gamma 1 2.23
TUBB tubulin, beta polypeptide 2.08
PLEK2 pleckstrin 2 2.01
DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 1.97 TUBB2 tubulin, beta 2 1.56
HSP90AA1 heat shock protein 90kDa alpha 1.43
TUBA6 tubulin, alpha 6 1.10
Group 5: Cellular protein metabolism
DPP4 dipeptidylpeptidase 4 6.94
PTPRR protein tyrosine phosphatase, receptor type, R 5.88
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 3.59
FAP fibroblast activation protein, alpha 2.84
MVK mevalonate kinase (mevalonic aciduria) 2.49
LRP8 low density lipoprotein receptor-related protein 8, 2.47
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 2.47
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.43
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3) 2.43
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.25
CACYBP calcyclin binding protein 2.22
HSPA8 heat shock 70kDa protein 8 2.21
CAPN9 calpain 9 2.13
TCP1 t-complex 1 2.11
YBX2 Y box binding protein 2 2.01
F12 coagulation factor XII (Hageman factor) 1.99
HSPE1 heat shock 10kDa protein 1 1.96
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 1.87 TFRC transferrin receptor (p90, CD71) 1.60
Group 6: Other Genes
HBA1/2 hemoglobin, alpha 1/2 28.63
C9orf26 chromosome 9 open reading frame 26 (NF-HEV) 15.70
CLIC5 chloride intracellular channel 5 14.11
ITM2A integral membrane protein 2A 12.90
MAOA monoamine oxidase A 6.19
CRIP1 cysteine-rich protein 1 (intestinal) 5.92
FGFBP1 fibroblast growth factor binding protein 1 5.67
IFI16 interferon, gamma-inducible protein 16 5.23
ALDH3A1 aldehyde dehydrogenase 3 family, memberA1 5.20
CALB2 calbindin 2, 29kDa (calretinin) 4.23
INSIG1 insulin induced gene 1 3.97
DKFZP564O0823 DKFZP564O0823 protein 3.60
KITLG KIT ligand 3.54
PLLP plasma membrane proteolipid (plasmolipin) 3.45
PSTPIP2 proline-serine-threonine phosphatase 3.42
TPM2 tropomyosin 2 (beta) 3.40
FXYD3 FXYD domain containing ion transport regulator 3 3.36
PSD3 pleckstrin and Sec7 domain containing 3 3.28
GOLPH2 golgi phosphoprotein 2 3.23
PTMA prothymosin, alpha 3.16 MTCP1 mature T-cell proliferation 1 2.98
RABIF RAB interacting factor 2.98
CKB creatine kinase, brain 2.94
SEMA3C semaphorin 3C 2.85
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 2.82
SLC6A20 solute carrier family 6 2.80
PROCR protein C receptor, endothelial (EPCR) 2.80
TSPAN1 tetraspanin 1 2.72
C1orf121 chromosome 1 open reading frame 121 2.67
SLC1A1 solute carrier family 1 2.61
MICB MHC class I polypeptide-related sequence B 2.60
NPAS2 neuronal PAS domain protein 2 2.53
ABHD6 abhydrolase domain containing 6 2.50
SWAP70 SWAP-70 protein 2.49
ELOVL6 ELOVL family member 6 2.48
STIP1 stress-induced-phosphoprotein 1 2.47
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 2.46
STEAP3 STEAP family member 3 2.46
MLSTD1 male sterility domain containing 1 2.44
UAP1L1 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 2.43
NAV3 neuron navigator 3 2.39
VAT1 vesicle amine transport protein 1 homolog 2.33
NDRG2 NDRG family member 2 2.29 DCC1 defective in sister chromatid cohesion homolog 1 2.27
PARVB parvin, beta 2.25
MAK3 N-acetyltransferase 13 2.18
SPBC25 spindle pole body component 25 homolog 2.17
ENDOD1 endonuclease domain containing 1 2.16
MFGE8 milk fat globule-EGF factor 8 protein 2.14
CCDC69 coiled-coil domain containing 69 2.08
SPAG9 sperm associated antigen 9 2.04
TMEM97 transmembrane protein 97 2.04
FABP5 fatty acid binding protein 5 (psoriasis-associated) 2.03
FLJ20647 hypothetical protein FLJ20647 1.96
C20orf27 chromosome 20 open reading frame 27 1.95
TRPM2 transient receptor potential cation channel 1.95
STRA13 stimulated by retinoic acid 13 homolog 1.93
CEACAM6 carcinoembryonic antigen-related cell adhesion 6 1.92
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 1.88
C4orf18 chromosome 4 open reading frame 18 1.88
CKMT1A/B creatine kinase, mitochondrial 1A/1B 1.84
TRIP13 thyroid hormone receptor interactor 13 1.81
SLC29A1 solute carrier family 29, member 1 1.79
RHOT2 ras homolog gene family, member T2 1.79
S100A6 S100 calcium binding protein A6 (calcyclin) 1.78
ATP10A ATPase, Class V, type 10A 1.77 DBI diazepam binding inhibitor 1.74
BRRN1 non-SMC condensin I complex, subunit H 1.73
CCNA2 cyclin A2 1.71
HSPC176 hematopoietic stem/progenitor cells 176 1.71
IFI30 interferon, gamma-inducible protein 30 1.70
MVP major vault protein 1.67
LRRC19 leucine rich repeat containing 19 1.54
LGALS3 lectin, galactoside-binding, soluble, 3 1.50
MSN moesin 0.96
PIGR polymeric immunoglobulin receptor 0.64
*Highlighted genes (in yellow) are upregulated in both Ls174T L1-CAM transfected cells and in human colon carcinoma tissue samples.