Schizophrenia a Disease Mediated by Neuroinflammation, Neurotransmitters, Or Both?

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PLEASE TYPE THE UNIVERSITY OF NEW SOUTH WALES Thesis/Dissertation Sheet

Surname or Family name: Fillman

First name: Stu Other name/s:

Abbreviation for degree as given in the University calendar: PhD

School: School of Psychiatry Faculty: Medicine

Title: Schizophrenia a disease mediated by neuroinflammation, neurotransmitters, or both?

Abstract 350 words maximum: (PLEASE TYPE) Schizophrenia is a disease characterized by both positive symptoms such as hallucinations and delusions as well as negative symptoms, including cognitive and behavior issues which may arise from either neurodevelopmental or neurodegenerative causes. These causes may involve either neurotransmitter systems including glutamate, dopamine, GABA and serotonin or an ongoing neuroinflammatory process. In this body we used samples from the dorsolateral prefrontal cortex (DLPFC) of 68 individuals throughout development and 74 individuals from a matched case control cohort. We examined the GABAA receptor as well as the serotonin receptor mRNA through quantitative-PCR. Furthermore to establish exactly what alterations in the GABAA receptor occur in schizophrenia we supplemented our developmental studies with qPCR and in vitro autoradiography. To examine more broadly changes which occur in the entire DLPFC we perform RNA-Seq in a subcohort of 20 individuals with schizophrenia and their matched controls. Targets were further characterized using immunohistochemistry, western blotting and qPCR.

GABAA receptor mRNA expression changes extensively through development with two programs occurring, subunits with decreasing expression and a corresponding group with a more dynamic path. In schizophrenia there is an increase in in vitro binding to the GABAA receptor at both the GABA and benzodiazepine binding sites which are not linked to broad increases in subunit mRNA expression but do correlate with 4 and 2S subunit mRNAs respectively. Serotonin receptors also change broadly throughout development but with concurrent inhibitory and excitatory receptors mRNA expression increases indicating a systemic balance. Broadly in the DLPFC of individuals with schizophrenia there was an increase in markers of neuroinflammation, including cytokines (IL-6, IL-8), associated molecules (SERPINA3) and microglial cells. This change was driven by a group comprising of 40% of the individuals with schizophrenia.

Our results show that both the GABAA and serotonin receptor systems have a protracted developmental program but changes in either system’s normal development cannot explain those observed in schizophrenia. The

GABAA receptor elevated binding displays weak associations with subunit mRNA levels, and is likely post- translational. The serotonin system’s dynamic changes indicate differential effects of drugs targeting these receptors throughout development. Finally, in schizophrenia our biological subgroup showing or displaying elevated neuroinflammation provides a novel therapeutic target for interventions.

Declaration relating to disposition of project thesis/dissertation

I hereby grant to the University of New South Wales or its agents the right to archive and to make available my thesis or dissertation in whole or in part in the University libraries in all forms of media, now or here after known, subject to the provisions of the Copyright Act 1968. I retain all property rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertation.

The University recognises that there may be exceptional circumstances requiring restrictions on copying or conditions on use. Requests for restriction for a period of up to 2 years must be made in writing. Requests for a longer period of restriction may be considered in exceptional circumstances and require the approval of the Dean of Graduate Research.

FOR OFFICE USE ONLY Date of completion of requirements for Award:

THIS SHEET IS TO BE GLUED TO THE INSIDE FRONT COVER OF THE THESIS

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105 Table 5.3: Major and minor cortical cellular distribution of the analyzed serotonin receptors

Pyramidal neurons Interneurons Htr1A * (25, 26, 24, 27, 75) Htr1A (27, 75) Htr2A * (25, 26, 24, 27, 75) Htr2A (27,100, 99) Htr4 (45, 21, 46) Htr2C (26, 37, 35) Htr5A (26, 42, 41) Htr6 (48, 47)

* Htr1A and Htr2A are highly co-expressed in prefrontal pyramidal neurons (24, 27). Bold font denotes predominant cellular localization in cerebral cortex. Italic font denotes lesser cellular localization for receptors expressed in both excitatory and inhibitory neurons. Information sourced from (Burnet et al., 1995, Cozzi and Nichols, 1996, Pasqualetti et al., 1996, Vysokanov et al., 1998, Oliver et al., 2000, Feng et al., 2001, Kinsey et al., 2001, Amargós-Bosch et al., 2004, Béïque et al., 2004a, Santana et al., 2004, Lucas et al., 2005, de Almeida and Mengod, 2007, Liu et al., 2007, de Almeida and Mengod, 2008, Schechter et al., 2008, Riccio et al., 2009)

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Abbreviations: m, male; f, female; PMI, post-mortem interval defined as interval between death and freezing of the brain; AA, African American; C, Caucasian; RIN, RNA integrity number; SIDS, sudden infant death syndrome; MVA, motor vehicle accident; SVCS, Superior Vena Cava Stenosis; ASCVD, Arteriosclerotic Cardiovascular Disease; HASCVD, Hypertensive Arteriosclerotic Cardiovascular Disease

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Table 6.1: Demographics of schizophrenia and matched control subjects in the New South Wales Tissue Resource Center post-mortem brain tissue cohort. Whole Cohort Sequencing Cohort

Schizophrenia Control Schizophrenia Control Demographic (n=37) (n=37) (n=20) (n=20) Age in years (range) 51.3 (27-75) 51.1 (18-78) 47.3 (27-75) 47.7 (18-74) Gender 13F : 24M 7F : 30M 20M 20M Hemisphere 17R : 20L 23R : 14L 7R : 13L 11R : 9L pH ± SD 6.61 ± 0.30 6.66 ± 0.29 6.63 ± 0.24 6.67 ± 0.24 24.80 ± PMI (hours) ± SD 28.46 ± 13.77 10.97 29.59 ± 16.11 24.23 ± 11.06 69.62 ± Months of Freezer Storage ± SD 78.89 ± 37.24 42.71 91.05 ± 36.03 94.20 ± 40.34 RIN ± SD 7.28 ± 0.58 7.30 ± 0.57 7.24 ± 0.78 7.36 ± 0.39 Age (y) at onset (range) 23.70 (14-40) 23.9 (17-40) Duration of illness (y) ± SD 27.62 ± 13.82 23.4 ± 12.41 691.64 ± 594.94 ± Chlorpromazine median dose (mg) 502.20 280.11 SD – standard deviation, PMI – post-mortem interval, RIN – RNA integrity number Further demographic detail for individuals is available in Supplementary Table 6.1

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. Inflammatory History last #' & Manner week prior to % !!$& ( $ & " / $%0 RIN Hemi Race Cause of Death of Death Toxicology at Post Mortem death Subclas : # >: >2?B :; 6.2 R C Congestive cardiac N Lithium 20mg/L; Midazolam No Residual failure 0.02mg/L ; ' >? ?2:? :> 6.7 L C COPD N Nil detected Yes Disorgani d < ' >; ?2<> =? 7.1 R C Cardiomegaly N TOX not performed No Undiffere ated = # ?A ?2;= <; 7.5 L C Acute pancreatitis N Alcohol 0.055g/100ml Yes Undiffere ated with substance dependen disorder. > ' >= ?2:B ;@2> 6.3 R C Coronary artery N Chlorpromazine: 0.7mg/L; Yes Paranoid thrombosis Diazepam: <0.1mg/L; Nordiazepam: 0.1mg/L; Insulin: 2 uU/mL ? # >A ?2<= :B 6.8 R C Sepsis and chronic N Morphine: 0.06mg/L, Codeine: Yes Paranoid renal failure 0.05mg/L, Carbamazepine: 7mg/L, Pethidine: 0.1mg/L, Paracetamol: 6mg/L, Metoclopramide 0.1mg/L, Diazepam: <0.1mg/L @ # ?? ?2<< :;2> 6.6 R C Faecaloid peritonitis N Nil detected Yes Paranoid A # >> ?2<9 <<2> 7.6 L C ASCVD N Amisulpride 18mg/L; Yes Undiffere Clozapine 1.4mg/L ated :; # 3 ?: ?2=< :@ 6.8 R C Myocarditis N Clozapine: 0.4mg/L; Lithium: Yes Bipolar 0.1mg/L :< # ?@ ?2== ;@ 6.3 L C Emphysema, right N Benztropine 0.2mg/L; Yes Disorgani lung Mesoridazine 0.9mg/L; d Thioridazine 0.6mg/L; Paracetamol < 3.0mg/L := ' @> ?2>? ' =9 ?2>9 ;:2> 7.6 L C Obstructive sleep N Valproic acid 20mg/L; No Paranoid apnea, dihydrocodeine 0.7mg/L; dihydrocodeine quetiapine 0.3mg/l; sertraline toxicity 0.3mg/L :? ' == ?2>; ;B2> 7.3 L C Hanging, suicide S Urine THC detected No Undiffere ated :@ ' >: ?2>< ;: 6.9 L C Ischaemic heart N Thioridazine 2.2mg/L ; Yes Residual disease Mesoridazine 2.4mg/L :A ' ;@ ?2>? :9 7.0 L C Clozapine toxicity U Clozapine 8.6mg/L No Undiffere ated :B ' >: ?2?A :A 7.9 L C Ischaemic heart N Nil detected No Paranoid disease ;9 ' >; ?2@9 A2= 7.7 R C Ischaemic heart N Temazepam <0.1mg/L Yes Paranoid disease ;: ' >@ ?2@; =A 6.5 R C ASCVD N Carbamazepine 10 mg/L, No Paranoid citalopram 0.2 mg/L, quetiapine <0.1 mg/L ;; ' << ?2@> =A 8.3 L C Hanging, suicide S Doxylamine: 0.9mg/L; No Paranoid Olanzapine: 0.2mg/L; Paracetamol: 3mg/L ;< ' <9 ?2@@ ;= 7.3 L C CO poisoning, S Carbon Monoxide 74% No Paranoid suicide saturation; Clozapine 0.7mg/L ;= # 3 @< ?2@B := 7.0 L C Asphyxia, choked A Fluoxetine: 0.2mg/L; 7-amino No Depressiv on food nitrazepam: 0.1mg/L; diazepan: with <0.1mg/L; paracetamol prominent :<3mg/L negative symptoms ;> # >? ?2A: <= 7.7 L C Pulmonary N Paracetamol 4.5mg/L Yes Disorgani thrombo-embolism d ;? ' ;@ ?2A; 8.0 L C Myocarditis N Clozapine 0.9mg/L No Undiffere ated ;@ # 3 <= ?2B> ;? 7.3 R A Hanging, suicide S Carbamazepine (1mg/L) No Bipolar

151 ;A # 3 << ?2B< >9 8.1 R C Hanging, suicide S Nil detected No Depressiv with prominent negative features o psychosis ;B ' >@ ?2BA

<: ' >B ?2A@ ;?2> 7.6 R C Ischaemic heart N TOX not performed Yes Disorgani disease d with prominent negative symptoms <; # 3 @< ?2B ;9 7.2 L C Right ventricular N Doxepin 0.1mg/L, No Depressiv dysplasia chlorpheniramine 01, (Uhl' s anomaly) trifluoperazine 01., codeine 0.05, pseudoephedrine 0.1, paracetamol 10mg/L << # 3 <9 @29: ;? 7.2 L C Hanging, suicide S Venlafaxine 0.9mg/l No Depressiv <= # ?: ?2B: =; 6.8 R C ASCVD N Clozapine 1.1mg/L; diazepam No Paranoid 0.2mg/L; Laudanosine 0.4mg/L; Nordiazepame 0.4mg/L; Olanzapine 0.2mg/L <> ' <; ?2BB ;? 7.9 L C Hanging, suicide S Priadel 400 mg, carbamazepine No Disorgani 400 mg-600mg, pimozine 4mg, d lithium carbonate, chlorpromazine, fluphenazine decanoate, pimozide, thioridazine 8.4 L C Ischaemic heart N Nil detected No Undiffere disease ated <@ # >? @29B 2A= ;B 6.7 L C Acute MI N Nil detected No

7.1 R C Bacterial Peritonitis, N Nil detected Yes stomach tumor

=9 ' <@ ?2;< :: 6.9 R C Pulmonary N Nil detected No

152 Embolism

=: # @A ?2;B ?2> 7.5 L C Adenocarcinoma N TOX not performed Yes (lung, rectum)

=; # ?: ?2<: ;@2> 6.6 R C Ischaemic heart N TOX not performed No disease =< ' @= ?2<: :9 7.4 L C Respiratory arrest N Nil detected Yes == # @A ?2<@ :: 6.1 R C Respiratory failure N control less 20g Yes due to pulmonary fibrosis => # >? ?2=@ ;< 7.1 R C Pulmonary N Nil detected Yes thrombo-embolus =? ' ?9 ?2>> ;: 7.8 L C Acute MI N Bld Alc: 0.251g per 100mL Yes paracetamol <3mgL

=@ # ?9 ?2>; :< 7.4 L C Ischaemic heart N Nil detected No disease =A # ?; ?2>@ <@2> 7.5 R C Acute MI N TOX not performed No =B ' >9 ?2?: :B 6.9 L C Ischaemic heart N Nil detected No disease >9 ' >A ?2>? :; 7.6 L C Ischaemic heart N Nil detected No disease >: ' @< ?2>@ =A29 8.1 R C Ischaemic heart N TOX not performed No disease. >; ' =? ?2?> ;> 7.3 R C Mitral valve N Nil detected No prolapse >< # =B ?2?= :> 8.3 R C Probable ARVD N Nil detected No >= ' >? ?2?= ;= 7.1 R C Coronary artery N TOX not performed No atheroma >> ' <= ?2>: ;92> 7.1 R C Acute exacerbation N TOX not performed Yes of asthma >? ' == ?2@; >9 7.2 L C Ischaemic heart N Nil detected No disease >@ ' >9 ?2?A ;B 8.1 R C Ischaemic Heart N Nil detected No Disease >A # >< ?2@9 ;@ 7.1 R C Acute MI N TOX not performed No >B ' =< ?2@: :< 7.4 R C Thrombotic N Nil detected Yes coronary artery occlusion

153 ?9 ' 7.7 L C ASCVD N Nil detected No ?: # ?9 ?2B> ;:2> 6.9 R C Ischaemic heart N TOX not performed No disease ?; # >= ?2A9 ;B 6.0 R A Coronary artery N TOX not performed No atheroma ?< # :A ?2@B << 7.0 L C Probable N Paracetamol (24mg/L); No hypertrophic lignocaine (1mg/L) cardiomyopathy ?= # <@ ?2A9 ;: 7.6 L C Ischaemic heart N Nil detected No disease ?> # ;: ?2A< 8.1 R C Primary cardiac N Nil detected Yes arrhythmia ?? # >: @2:> <@2> 7.7 R C Acute MI N TOX not performed Yes ?@ # << ?2B: ;= 8.0 L C Cardiac arrythmia; N Nil detected No myocardial fibrosis ?A ' >B ?2B? ;9 7.4 R C Coronary N Nil detected Yes thrombosis ?B # ?= @29: 7.0 R C Coronary artery N TOX not performed No thrombosis @9 # ;= ?2B> =< 7.1 R C Probable idiopathic N Nil detected No cardiac arrhythmia

@: # >@ ?2A? :A 8.4 L C Ischaemic heart N Nil dectected No disease @; ' <@ ?2B= ;= 7.5 R C Electrocution A Codeine <0.5mg/L; paracetamol No 3mg/L; lignocaine <0.5mg/L

@< # >? ?2BA <@ 6.2 R C Hypertension, N TOX not performed Yes cardiomegaly @= ' >> @2:B ;9 7.3 L C Cardiac arrest due N Nil detected Yes to emphzyma, pneumothorax

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log NCBI ID Conc Log FC p-value FDR Duplicate Symbol Entrez Gene Name Location Type(s) ADAM metallopeptidase with NM_182920 -16.51 1.127 2.19E−12 0.000 ADAMTS9 thrombospondin type 1 motif, 9 Extracellular Space peptidase

NM_001167749 -19.67 0.868 1.90E−06 0.000 ADCY10 adenylate cyclase 10 (soluble) Cytoplasm enzyme Extracellular NM_001124 -19.16 1.225 1.65E−11 0.000 ADM adrenomedullin Space other

NM_000697 -25.09 −3.742 1.58E−10 0.000 ALOX12 arachidonate 12-lipoxygenase Cytoplasm enzyme Extracellular NM_139314 -18.29 1.013 1.30E−09 0.000 D ANGPTL4 angiopoietin-like 4 Space other

NM_001039667 -18.41 1.006 1.98E−09 0.000 D ANGPTL4 angiopoietin-like 4 Extracellular Space other

NM_145660 -21.09 2.080 3.66E−21 0.000 D APOL4 apolipoprotein L, 4 unknown other

NM_030643 -21.06 2.051 5.70E−21 0.000 D APOL4 apolipoprotein L, 4 unknown other

NM_032487 -18.78 1.464 7.72E−18 0.000 ARPM1 actin related protein M1 unknown other

NM_020801 -15.00 0.883 1.77E−08 0.000 ARRDC3 arrestin domain containing 3 unknown other

NM_004314 -24.91 2.816 1.70E−06 0.000 ART1 ADP-ribosyltransferase 1 Plasma Membrane enzyme

NM_130387 -37.26 25.506 2.90E−07 0.000 D ASB14 ankyrin repeat and SOCS box containing 14 unknown other

NM_001142733 -25.62 3.389 3.09E−07 0.000 D ASB14 ankyrin repeat and SOCS box containing 14 unknown other

NM_004281 -15.84 2.708 1.12E−58 0.000 BAG3 BCL2-associated athanogene 3 Cytoplasm other

NR_027795 -21.09 1.951 1.08E−18 0.000 BTN2A3 butyrophilin, subfamily 2, member A3 unknown other

NM_007021 -17.25 0.904 1.87E−08 0.000 C10orf10 chromosome 10 open reading frame 10 Cytoplasm other

NM_001168390 -19.06 1.006 2.72E−09 0.000 D C10orf105 chromosome 10 open reading frame 105 unknown other

156

NM_001164375 -19.06 1.000 3.29E−09 0.000 D C10orf105 chromosome 10 open reading frame 105 unknown other

NM_007354 -24.11 2.139 2.12E−06 0.000 C3orf27 chromosome 3 open reading frame 27 unknown other

NM_001098786 -17.36 1.434 9.38E−19 0.000 D C7orf68 chromosome 7 open reading frame 68 Cytoplasm other

NM_013332 -17.34 1.432 1.00E−18 0.000 D C7orf68 chromosome 7 open reading frame 68 Cytoplasm other

NM_001010907 -22.98 1.787 9.01E−09 0.000 C9orf153 chromosome 9 open reading frame 153 unknown other

NM_001218 -19.38 0.930 1.39E−07 0.000 CA12 carbonic anhydrase XII Plasma Membrane enzyme

NM_206925 -19.38 0.930 1.39E−07 0.000 CA12 carbonic anhydrase XII Plasma Membrane enzyme cyclin-dependent kinase inhibitor 1A (p21, NR_037151 -17.76 0.948 6.27E−09 0.000 CDKN1A Cip1) Nucleus other cyclin-dependent kinase inhibitor 1A (p21, NM_000389 -17.76 0.945 6.82E−09 0.000 CDKN1A Cip1) Nucleus other cyclin-dependent kinase inhibitor 1A (p21, NM_078467 -17.77 0.943 7.42E−09 0.000 CDKN1A Cip1) Nucleus other cyclin-dependent kinase inhibitor 1A (p21, NR_037150 -17.77 0.943 7.42E−09 0.000 CDKN1A Cip1) Nucleus other cyclin-dependent kinase inhibitor 1A (p21, NR_037152 -17.77 0.943 7.42E−09 0.000 CDKN1A Cip1) Nucleus other

NM_006382 -24.79 2.602 9.07E−07 0.000 CDRT1 CMT1A duplicated region transcript 1 unknown other

NM_001025197 -21.38 1.306 7.63E−10 0.000 D CHI3L2 chitinase 3-like 2 Extracellular Space enzyme

NM_004000 -21.38 1.306 7.63E−10 0.000 D CHI3L2 chitinase 3-like 2 Extracellular Space enzyme

NM_001025199 -21.47 1.265 4.13E−09 0.000 D CHI3L2 chitinase 3-like 2 Extracellular Space enzyme cysteine and histidine-rich domain (CHORD) NM_012124 -16.10 0.803 3.93E−07 0.000 CHORDC1 containing 1 unknown other cysteine and histidine-rich domain (CHORD) NM_001144073 -16.11 0.802 4.02E−07 0.000 CHORDC1 containing 1 unknown other

NM_013252 -23.19 1.919 2.90E−09 0.000 CLEC5A C-type lectin domain family 5, member A Plasma Membrane other Extracellular NM_000096 -18.28 1.444 5.50E−18 0.000 CP ceruloplasmin (ferroxidase) Space enzyme

NM_001885 -13.20 1.031 4.82E−11 0.000 CRYAB crystallin, alpha B Nucleus other

157 transcription NM_003651 -18.72 1.035 2.67E−09 0.000 D CSDA cold shock domain protein A Nucleus regulator transcription NM_001145426 -18.83 1.036 3.39E−09 0.000 D CSDA cold shock domain protein A Nucleus regulator

NM_172211 -18.16 0.804 9.06E−07 0.000 CSF1 colony stimulating factor 1 (macrophage) Extracellular Space cytokine

NM_000757 -17.68 0.791 9.88E−07 0.000 CSF1 colony stimulating factor 1 (macrophage) Extracellular Space cytokine

NM_172212 -17.93 0.763 2.50E−06 0.000 CSF1 colony stimulating factor 1 (macrophage) Extracellular Space cytokine cell wall biogenesis 43 C-terminal homolog NM_025087 -26.46 4.858 6.09E−07 0.000 CWH43 (S. cerevisiae) unknown other

NM_017539 -21.72 −1.410 1.60E−08 0.000 DNAH3 dynein, axonemal, heavy chain 3 unknown enzyme DnaJ (Hsp40) homolog, subfamily B, NM_006145 -13.93 1.919 9.23E−33 0.000 DNAJB1 member 1 Nucleus other

NM_001941 -25.37 −4.008 1.04E−08 0.000 D DSC3 desmocollin 3 Plasma Membrane other

NM_024423 -25.37 −4.008 1.04E−08 0.000 D DSC3 desmocollin 3 Plasma Membrane other family with sequence similarity 115, member NM_001130026 -19.69 0.900 3.06E−07 0.000 FAM115C C unknown other

NR_028336 -25.62 3.381 1.49E−06 0.000 FAM27L family with sequence similarity 27-like unknown other family with sequence similarity 46, member NM_017633 -17.94 0.841 2.97E−07 0.000 FAM46A A unknown other ficolin (collagen/fibrinogen domain Extracellular NM_003665 -24.63 2.532 1.10E−06 0.000 D FCN3 containing) 3 (Hakata antigen) Space other ficolin (collagen/fibrinogen domain Extracellular NM_173452 -24.63 2.532 1.10E−06 0.000 D FCN3 containing) 3 (Hakata antigen) Space other

NM_031471 -20.30 1.330 1.45E−12 0.000 D FERMT3 fermitin family member 3 Cytoplasm enzyme

NM_178443 -20.29 1.323 1.69E−12 0.000 D FERMT3 fermitin family member 3 Cytoplasm enzyme G-protein coupled NM_005303 -24.02 1.897 1.07E−06 0.000 FFAR1 free fatty acid receptor 1 Plasma Membrane receptor FXYD domain containing ion transport NM_001136010 -24.01 2.351 7.55E−08 0.000 D FXYD3 regulator 3 unknown other FXYD domain containing ion transport NM_001136009 -23.90 2.169 1.49E−07 0.000 D FXYD3 regulator 3 unknown other

158 FXYD domain containing ion transport NM_001136007 -22.14 1.143 6.98E−07 0.000 D FXYD3 regulator 3 unknown other FXYD domain containing ion transport NM_001136011 -22.17 1.139 7.48E−07 0.000 D FXYD3 regulator 3 unknown other FXYD domain containing ion transport NM_005971 -22.20 1.165 7.74E−07 0.000 D FXYD3 regulator 3 unknown other FXYD domain containing ion transport NM_001136012 -22.18 1.128 1.12E−06 0.000 D FXYD3 regulator 3 unknown other FXYD domain containing ion transport NM_021910 -22.16 1.102 1.55E−06 0.000 D FXYD3 regulator 3 unknown other

NM_015714 -20.40 1.362 9.38E−12 0.000 G0S2 G0/G1switch 2 unknown other gamma-aminobutyric acid (GABA) A NM_004961 -19.88 1.024 7.58E−09 0.000 GABRE receptor, epsilon Plasma Membrane ion channel

NM_021954 -36.96 26.110 6.65E−10 0.000 GJA3 gap junction protein, alpha 3, 46kDa Plasma Membrane transporter

NM_006433 -21.67 −1.196 1.88E−07 0.000 D GNLY granulysin Cytoplasm other

NM_012483 -21.55 −1.164 1.92E−07 0.000 D GNLY granulysin Cytoplasm other glycoprotein Ib (platelet), alpha NM_000173 -24.87 3.410 1.54E−09 0.000 GP1BA polypeptide Plasma Membrane other G-protein coupled NM_020370 -23.12 1.735 6.78E−08 0.000 GPR84 G protein-coupled receptor 84 Plasma Membrane receptor

NM_144594 -24.27 −2.418 2.53E−07 0.000 GTSF1 gametocyte specific factor 1 Cytoplasm other granzyme A (granzyme 1, cytotoxic T- NM_006144 -24.52 −2.251 2.39E−06 0.000 GZMA lymphocyte-associated serine esterase 3) Cytoplasm peptidase

NM_001099414 -21.93 −1.441 1.86E−09 0.000 D HAVCR1 hepatitis A virus cellular receptor 1 Plasma Membrane other

NM_001173393 -21.93 −1.441 1.86E−09 0.000 D HAVCR1 hepatitis A virus cellular receptor 1 Plasma Membrane other

NM_012206 -21.77 −1.202 1.94E−07 0.000 D HAVCR1 hepatitis A virus cellular receptor 1 Plasma Membrane other

NM_018410 -24.72 −2.880 7.65E−08 0.000 HJURP Holliday junction recognition protein Nucleus other

HSPA1A/HS NM_005345 -15.36 2.618 9.11E−56 0.000 D PA1B heat shock 70kDa protein 1A Cytoplasm other

NM_005346 -14.91 1.979 2.19E−34 0.000 D HSPA1A/HS heat shock 70kDa protein 1A Cytoplasm other

159 PA1B

NM_002155 -20.88 5.689 3.56E−117 0.000 HSPA6 heat shock 70kDa protein 6 (HSP70B') unknown other

NR_024151 -21.37 2.258 6.51E−23 0.000 HSPA7 heat shock 70kDa protein 7 (HSP70B) unknown other

NM_001540 -17.38 2.019 1.97E−33 0.000 HSPB1 heat shock 27kDa protein 1 Cytoplasm other Extracellular NM_000576 -20.53 1.463 6.29E−14 0.000 IL1B interleukin 1, beta Space cytokine

transmembra NM_003856 -19.15 1.197 1.28E−11 0.000 D IL1RL1 interleukin 1 receptor-like 1 Plasma Membrane ne receptor

transmembrane NM_016232 -20.10 1.112 8.30E−09 0.000 D IL1RL1 interleukin 1 receptor-like 1 Plasma Membrane receptor Extracellular NM_000600 -22.45 1.164 2.88E−06 0.000 IL6 interleukin 6 (interferon, beta 2) Space cytokine Extracellular NM_000584 -20.56 1.256 3.06E−10 0.000 IL8 interleukin 8 Space cytokine

NM_001142883 -18.36 0.822 7.66E−07 0.000 IP6K3 inositol hexakisphosphate kinase 3 Cytoplasm kinase

NM_054111 -18.39 0.798 1.62E−06 0.000 IP6K3 inositol hexakisphosphate kinase 3 Cytoplasm kinase potassium voltage-gated channel, Isk-related NM_080671 -19.39 1.052 1.75E−09 0.000 KCNE4 family, member 4 Plasma Membrane ion channel transcription NM_004235 -18.45 −0.918 3.22E−08 0.000 KLF4 Kruppel-like factor 4 (gut) Nucleus regulator

NM_005356 -24.09 −2.372 1.31E−08 0.000 D LCK lymphocyte-specific protein tyrosine kinase Cytoplasm kinase

NM_001042771 -24.02 −2.101 8.29E−08 0.000 D LCK lymphocyte-specific protein tyrosine kinase Cytoplasm kinase G-protein leucine-rich repeat containing G protein- coupled NM_001017403 -21.74 −1.088 6.97E−07 0.000 D LGR6 coupled receptor 6 Plasma Membrane receptor G-protein leucine-rich repeat containing G protein- coupled NM_021636 -21.74 −1.082 6.97E−07 0.000 D LGR6 coupled receptor 6 Plasma Membrane receptor G-protein leucine-rich repeat containing G protein- coupled NM_001017404 -21.92 −1.104 9.43E−07 0.000 D LGR6 coupled receptor 6 Plasma Membrane receptor leukemia inhibitory factor (cholinergic Extracellular NM_002309 -23.03 2.322 1.25E−13 0.000 LIF differentiation factor) Space cytokine

160

LOC1001290 NR_034091 -23.49 −1.775 3.22E−07 0.000 46 hypothetical LOC100129046 unknown other

LOC1001305 NR_028339 -19.03 1.006 5.50E−09 0.000 D 22 hypothetical LOC100130522 unknown other

LOC1001339 NR_027444 -21.77 1.398 2.21E−09 0.000 D 57 hypothetical LOC100133957 unknown other

LOC1004991 NR_034092 -18.50 1.554 7.14E−20 0.000 83 hypothetical LOC100499183 unknown other

NR_034157 -22.40 1.977 7.62E−13 0.000 LOC340515 hypothetical LOC340515 unknown other PI-3-kinase-related kinase SMG-1 NR_002473 -20.52 0.959 3.87E−07 0.000 LOC440354 pseudogene unknown other

NM_001178102 -20.43 1.055 1.11E−08 0.000 D LOX lysyl oxidase Extracellular Space enzyme Extracellular NM_002317 -20.30 1.016 2.14E−08 0.000 D LOX lysyl oxidase Space enzyme Extracellular NM_006610 -37.30 25.436 1.01E−06 0.000 D MASP2 mannan-binding lectin serine peptidase 2 Space peptidase

NM_001166346 -22.69 1.517 6.71E−08 0.000 D MDFIC MyoD family inhibitor domain containing Nucleus other Extracellular NM_006533 -25.32 3.974 7.80E−11 0.000 D MIA melanoma inhibitory activity Space other

NM_001202553 -25.37 3.063 1.83E−07 0.000 D MIA melanoma inhibitory activity Extracellular Space other

NR_031733 -26.27 5.237 3.04E−08 0.000 mir-1912 microRNA 1912 unknown microRNA

NR_029837 -22.18 −1.433 1.16E−07 0.000 D mir-219 microRNA 219-2 unknown microRNA

NR_029868 -23.96 −1.888 1.55E−06 0.000 D mir-368 microRNA 376c unknown microRNA

NR_036146 -22.10 1.265 7.22E−07 0.000 D mir-548 microRNA 548c unknown microRNA

NR_030373 -37.17 25.685 5.41E−07 0.000 mir-643 microRNA 643 unknown microRNA

NR_030374 -25.16 3.494 4.79E−09 0.000 mir-644 microRNA 644 unknown microRNA

NR_030640 -37.24 25.543 1.01E−06 0.000 mir-942 microRNA 942 unknown microRNA

161

NR_031593 -24.29 −2.414 5.23E−07 0.000 MIR1182 microRNA 1182 unknown microRNA

NR_031700 -24.04 2.272 9.96E−07 0.000 MIR1252 microRNA 1252 unknown microRNA

NR_031698 -25.90 −4.128 2.18E−07 0.000 MIR1288 microRNA 1288 unknown microRNA

NR_037403 -14.61 0.761 1.12E−06 0.000 MIR3609 microRNA 3609 unknown microRNA

NM_152649 -18.84 0.999 1.16E−08 0.000 MLKL mixed lineage kinase domain-like unknown kinase

NM_001142497 -19.35 0.970 1.34E−07 0.000 MLKL mixed lineage kinase domain-like unknown kinase

NM_002427 -37.20 −25.630 5.01E−07 0.000 MMP13 matrix metallopeptidase 13 (collagenase 3) Extracellular Space peptidase

NM_178176 -37.10 25.831 1.35E−08 0.000 MOGAT3 monoacylglycerol O-acyltransferase 3 unknown enzyme transcription NM_005098 -21.22 −1.062 1.02E−06 0.000 MSC musculin Cytoplasm regulator

NM_001029861 -26.44 4.893 2.71E−07 0.000 NANOS2 nanos homolog 2 (Drosophila) unknown other N-acetyltransferase 2 (arylamine N- NM_000015 -24.91 2.804 1.07E−06 0.000 NAT2 acetyltransferase) Cytoplasm enzyme

NCRNA0016 NR_026675 -22.04 1.545 7.82E−10 0.000 9 non-protein coding RNA 169 unknown other

NM_005601 -24.55 −3.183 1.15E−09 0.000 NKG7 natural killer cell group 7 sequence Plasma Membrane other NPC1 (Niemann-Pick disease, type C1, NM_001101648 -22.79 3.609 9.36E−32 0.000 D NPC1L1 gene)-like 1 Cytoplasm transporter NPC1 (Niemann-Pick disease, type C1, NM_013389 -22.79 3.609 9.36E−32 0.000 D NPC1L1 gene)-like 1 Cytoplasm transporter

NM_152635 -22.66 1.981 8.34E−11 0.000 OIT3 oncoprotein induced transcript 3 Nucleus other G-protein olfactory receptor, family 13, subfamily C, coupled NM_001001961 -23.19 1.500 2.51E−06 0.000 OR13C3 member 3 Plasma Membrane receptor G-protein olfactory receptor, family 1, subfamily J, coupled NM_054107 -24.26 −2.256 4.58E−07 0.000 OR1J2 member 2 Plasma Membrane receptor G-protein olfactory receptor, family 52, subfamily E, coupled NM_001005168 -25.09 2.945 7.74E−07 0.000 OR52E8 member 8 Plasma Membrane receptor

162

transmembrane NM_001168355 -19.23 0.907 1.81E−07 0.000 OSMR oncostatin M receptor Plasma Membrane receptor

transmembrane NM_003999 -17.18 0.769 1.62E−06 0.000 OSMR oncostatin M receptor Plasma Membrane receptor purinergic receptor P2X, ligand-gated ion NM_174873 -23.29 −1.864 1.34E−07 0.000 D P2RX2 channel, 2 Plasma Membrane ion channel purinergic receptor P2X, ligand-gated ion NM_174872 -23.28 −1.871 1.86E−07 0.000 D P2RX2 channel, 2 Plasma Membrane ion channel purinergic receptor P2X, ligand-gated ion NM_170683 -23.13 −1.770 2.57E−07 0.000 D P2RX2 channel, 2 Plasma Membrane ion channel purinergic receptor P2X, ligand-gated ion NM_012226 -23.22 −1.794 3.46E−07 0.000 D P2RX2 channel, 2 Plasma Membrane ion channel purinergic receptor P2X, ligand-gated ion NM_016318 -23.18 −1.772 4.64E−07 0.000 D P2RX2 channel, 2 Plasma Membrane ion channel purinergic receptor P2X, ligand-gated ion NM_170682 -23.15 −1.722 8.23E−07 0.000 D P2RX2 channel, 2 Plasma Membrane ion channel

NM_020144 -19.11 0.870 2.58E−07 0.000 PAPOLB poly(A) polymerase beta (testis specific) Nucleus enzyme phosphoinositide-3-kinase, regulatory NM_001010855 -21.93 −1.171 1.81E−06 0.000 PIK3R6 subunit 6 Cytoplasm other procollagen-lysine, 2-oxoglutarate 5- NM_001084 -17.23 0.762 2.03E−06 0.000 PLOD3 dioxygenase 3 Cytoplasm enzyme poly(A)-specific ribonuclease (PARN)-like NM_173516 -18.63 1.336 1.99E−15 0.000 PNLDC1 domain containing 1 unknown other protein phosphatase 1, regulatory NM_014330 -16.18 1.045 4.65E−11 0.000 PPP1R15A (inhibitor) subunit 15A Cytoplasm other protein phosphatase 1, regulatory (inhibitor) NM_024607 -18.67 0.840 5.40E−07 0.000 PPP1R3B subunit 3B Cytoplasm other protein phosphatase 1, regulatory (inhibitor) NM_001201329 -18.67 0.838 5.73E−07 0.000 PPP1R3B subunit 3B Cytoplasm other

NM_001083116 -22.70 −1.537 7.57E−09 0.000 D PRF1 perforin 1 (pore forming protein) Cytoplasm other

NM_005041 -22.70 −1.537 7.57E−09 0.000 D PRF1 perforin 1 (pore forming protein) Cytoplasm other

NM_006262 -23.21 1.656 5.74E−07 0.000 PRPH peripherin Plasma Membrane other

NM_001034836 -22.90 1.765 4.30E−09 0.000 D RDM1 RAD52 motif 1 unknown other

NM_001163125 -23.36 1.914 6.42E−09 0.000 D RDM1 RAD52 motif 1 unknown other

163

NM_001163130 -22.89 1.645 1.94E−08 0.000 D RDM1 RAD52 motif 1 unknown other

NM_001163122 -22.90 1.682 2.59E−08 0.000 D RDM1 RAD52 motif 1 unknown other

NM_001163121 -22.84 1.636 3.62E−08 0.000 D RDM1 RAD52 motif 1 unknown other

NM_145654 -22.83 1.601 6.43E−08 0.000 D RDM1 RAD52 motif 1 unknown other

NR_027999 -23.29 1.730 8.14E−08 0.000 D RDM1 RAD52 motif 1 unknown other

NR_028000 -23.26 1.681 1.60E−07 0.000 D RDM1 RAD52 motif 1 unknown other

NR_027998 -23.21 1.671 1.65E−07 0.000 D RDM1 RAD52 motif 1 unknown other

NM_001163124 -23.31 1.680 2.12E−07 0.000 D RDM1 RAD52 motif 1 unknown other

NR_027997 -23.18 1.624 3.11E−07 0.000 D RDM1 RAD52 motif 1 unknown other

NM_001163120 -23.23 1.622 4.16E−07 0.000 D RDM1 RAD52 motif 1 unknown other

NR_027996 -23.28 1.525 1.91E−06 0.000 D RDM1 RAD52 motif 1 unknown other

NM_002922 -18.32 −1.230 3.73E−13 0.000 RGS1 regulator of G-protein signaling 1 Plasma Membrane other Extracellular NM_006911 -23.55 2.296 6.91E−08 0.000 D RLN1/RLN2 relaxin 2 Space other

NM_001184993 -22.25 −1.658 4.36E−10 0.000 D RNF17 ring finger protein 17 Cytoplasm other

NM_031277 -22.25 −1.658 4.36E−10 0.000 D RNF17 ring finger protein 17 Cytoplasm other

NR_004393 -20.50 −1.019 1.86E−07 0.000 RNY4 RNA, Ro-associated Y4 unknown other

NM_001128850 -21.02 1.057 9.10E−07 0.000 D RRAD Ras-related associated with diabetes Cytoplasm enzyme

NM_004165 -21.02 1.057 9.10E−07 0.000 D RRAD Ras-related associated with diabetes Cytoplasm enzyme

NM_182704 -24.92 −2.913 8.81E−07 0.000 SELV selenoprotein V unknown other serpin peptidase inhibitor, clade A (alpha-1 Extracellular NM_001085 -17.70 2.040 8.54E−35 0.000 SERPINA3 antiproteinase, antitrypsin), member 3 Space other serpin peptidase inhibitor, clade C Extracellular NM_000488 -23.66 1.822 7.06E−07 0.000 SERPINC1 (antithrombin), member 1 Space other

164 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen Extracellular NM_001235 -17.88 3.277 1.97E−75 0.000 SERPINH1 binding protein 1) Space other transcription NM_005413 -20.93 1.082 5.24E−08 0.000 SIX3 SIX homeobox 3 Nucleus regulator

NM_033518 -18.31 −0.778 2.03E−06 0.000 SLC38A5 solute carrier family 38, member 5 Plasma Membrane transporter

NR_004384 -25.85 −4.223 2.16E−08 0.000 SNAR-F small ILF3/NF90-associated RNA F unknown other SNORD116- NR_003333 -18.93 0.970 1.06E−08 0.000 18 small nucleolar RNA, C/D box 116-18 unknown other SNORD116- NR_003338 -15.41 0.765 1.26E−06 0.000 24 small nucleolar RNA, C/D box 116-24 unknown other

NR_000025 -12.65 0.790 4.04E−07 0.000 SNORD15B small nucleolar RNA, C/D box 15B unknown other

NR_002598 -13.62 1.173 8.85E−14 0.000 SNORD87 small nucleolar RNA, C/D box 87 unknown other

NM_003955 -18.81 1.839 1.38E−24 0.000 SOCS3 suppressor of cytokine signaling 3 Cytoplasm other Extracellular NM_003155 -21.17 1.807 1.12E−16 0.000 STC1 stanniocalcin 1 Space kinase

NM_024636 -21.19 1.071 7.37E−08 0.000 STEAP4 STEAP family member 4 Plasma Membrane other Extracellular NM_006528 -24.00 −2.274 5.47E−07 0.000 TFPI2 tissue factor pathway inhibitor 2 Space other

transmembra NM_017442 -22.12 1.576 1.65E−09 0.000 TLR9 toll-like receptor 9 Plasma Membrane ne receptor

NM_030788 -21.21 −1.030 1.45E−06 0.000 TM7SF4 transmembrane 7 superfamily member 4 Plasma Membrane other

NM_001145303 -21.82 1.138 4.33E−07 0.000 D TMC4 transmembrane channel-like 4 unknown other

NM_144686 -21.82 1.138 4.33E−07 0.000 D TMC4 transmembrane channel-like 4 unknown other

NM_198154 -23.88 2.616 2.26E−11 0.000 TMEM95 transmembrane protein 95 unknown other tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death transmembrane NM_003840 -19.65 0.998 4.17E−08 0.000 TNFRSF10D domain Plasma Membrane receptor tumor necrosis factor (ligand) superfamily, NM_172014 -23.91 2.790 4.85E−12 0.000 D TNFSF14 member 14 Extracellular Space cytokine NM_003807 -23.80 2.564 4.98E−11 D TNFSF14 tumor necrosis factor (ligand) superfamily, Extracellular cytokine

165 0.000 member 14 Space transcription NM_006470 -18.91 0.990 4.77E−09 0.000 TRIM16 tripartite motif containing 16 Cytoplasm regulator

NM_033199 -24.95 3.231 1.64E−08 0.000 UCN2 urocortin 2 Extracellular Space other

NM_021628 -20.03 0.815 5.40E−06 0.001 ALOXE3 arachidonate lipoxygenase 3 unknown enzyme

NM_001165960 -20.04 0.799 8.48E−06 0.001 ALOXE3 arachidonate lipoxygenase 3 unknown enzyme

NR_033346 -25.65 3.301 6.34E−06 0.001 BOK-AS BOK antisense RNA (non-protein coding) unknown other

NM_001145652 -21.24 −0.975 6.90E−06 0.001 C6orf141 chromosome 6 open reading frame 141 unknown other

NR_034061 -22.88 −1.381 9.66E−06 0.001 D CASP12 caspase 12 (gene/pseudogene) Cytoplasm enzyme

NR_034070 -22.88 −1.381 9.66E−06 0.001 D CASP12 caspase 12 (gene/pseudogene) Cytoplasm enzyme

NM_001145355 -22.14 1.195 6.32E−06 0.001 D CBWD1 COBW domain containing 1 unknown other

NM_001145356 -22.14 1.195 6.32E−06 0.001 D CBWD1 COBW domain containing 1 unknown other

NM_018491 -22.14 1.195 6.32E−06 0.001 D CBWD1 COBW domain containing 1 unknown other

NM_001276 -16.49 0.713 5.72E−06 0.001 CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) Extracellular Space enzyme

NM_024877 -22.98 1.298 8.77E−06 0.001 CNTD2 cyclin N-terminal domain containing 2 unknown other

NM_172210 -18.18 0.758 3.66E−06 0.001 CSF1 colony stimulating factor 1 (macrophage) Extracellular Space cytokine cytochrome P450, family 39, subfamily A, NM_016593 -20.35 0.873 4.47E−06 0.001 CYP39A1 polypeptide 1 Cytoplasm enzyme

DKFZp686D NR_033974 -25.21 2.732 6.34E−06 0.001 0853 hypothetical LOC401613 unknown other

NM_001394 -16.71 −0.707 7.55E−06 0.001 DUSP4 dual specificity phosphatase 4 Nucleus phosphatase

NM_057158 -16.68 −0.704 8.14E−06 0.001 DUSP4 dual specificity phosphatase 4 Nucleus phosphatase family with sequence similarity 83, member NM_017708 -25.28 2.598 3.85E−06 0.001 FAM83E E unknown other G-protein NM_002029 -20.07 0.833 4.72E−06 0.001 FPR1 formyl peptide receptor 1 Plasma Membrane coupled

166 receptor G-protein coupled NM_005282 -20.46 0.890 5.34E−06 0.001 GPR4 G protein-coupled receptor 4 Plasma Membrane receptor

NM_000517 -17.16 0.722 8.14E−06 0.001 HBA1/HBA2 hemoglobin, alpha 1 Cytoplasm transporter

NM_000518 -16.17 0.701 8.37E−06 0.001 HBB hemoglobin, beta Cytoplasm transporter

NM_005330 -23.28 1.333 1.12E−05 0.001 HBE1 hemoglobin, epsilon 1 Cytoplasm transporter

transmembrane NM_000201 -19.18 0.757 9.28E−06 0.001 ICAM1 intercellular adhesion molecule 1 Plasma Membrane receptor

NM_006820 -16.30 −0.703 6.93E−06 0.001 IFI44L interferon-induced protein 44-like unknown other immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu NM_144646 -23.59 −1.642 7.48E−06 0.001 IGJ polypeptides Extracellular Space other

NM_001001694 -22.06 −1.097 5.60E−06 0.001 IL17REL interleukin 17 receptor E-like unknown other

NM_015167 -16.86 0.739 3.38E−06 0.001 JMJD6 jumonji domain containing 6 Plasma Membrane other

NM_014736 -22.87 1.462 3.36E−06 0.001 D KIAA0101 KIAA0101 Nucleus other

NM_001109997 -23.19 −1.484 7.58E−06 0.001 KLHL33 kelch-like 33 (Drosophila) unknown other

NM_001173129 -20.85 −0.916 3.27E−06 0.001 LOXHD1 lipoxygenase homology domains 1 Extracellular Space other

NM_001145473 -20.89 −0.923 3.62E−06 0.001 LOXHD1 lipoxygenase homology domains 1 Extracellular Space other

NR_030784 -37.28 25.474 3.55E−06 0.001 mir-155 microRNA 155 unknown microRNA

NR_031713 -24.58 2.320 5.57E−06 0.001 D mir-379 microRNA 380 unknown microRNA

NR_031753 -26.61 4.561 6.30E−06 0.001 MIR2276 microRNA 2276 unknown microRNA

NR_036191 -24.81 2.207 6.81E−06 0.001 MIR4306 microRNA 4306 unknown microRNA

NM_147191 -23.06 1.259 4.15E−06 0.001 MMP21 matrix metallopeptidase 21 Extracellular Space peptidase myosin, heavy chain 6, cardiac muscle, NM_002471 -26.65 4.496 3.51E−06 0.001 MYH6 alpha Cytoplasm enzyme

167

NM_002535 -18.06 −0.750 3.19E−06 0.001 OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa Cytoplasm enzyme

NM_001008496 -37.36 −25.305 3.70E−06 0.001 PIWIL3 piwi-like 3 (Drosophila) unknown other

NM_032562 -26.62 4.538 3.51E−06 0.001 PLA2G12B phospholipase A2, group XIIB Extracellular Space enzyme G-protein coupled NM_138964 -25.67 3.272 7.16E−06 0.001 PROKR1 prokineticin receptor 1 Plasma Membrane receptor transcription NM_032753 -37.39 25.256 6.69E−06 0.001 RAX2 retina and anterior neural fold homeobox 2 Nucleus regulator

NM_182973 -23.48 1.558 5.21E−06 0.001 TMPRSS9 transmembrane protease, serine 9 Plasma Membrane other tumor necrosis factor receptor NM_016639 -23.32 1.445 3.50E−06 0.001 TNFRSF12A superfamily, member 12A Plasma Membrane other

NM_001184739 -23.14 1.402 7.77E−06 0.001 D TSSK4 testis-specific serine kinase 4 unknown kinase

NM_174944 -23.14 1.402 7.77E−06 0.001 D TSSK4 testis-specific serine kinase 4 unknown kinase

NM_001033576 -24.30 2.033 3.73E−06 0.001 D UNC45B unc-45 homolog B (C. elegans) unknown other

NM_173167 -24.30 2.033 3.73E−06 0.001 D UNC45B unc-45 homolog B (C. elegans) unknown other

NM_018417 -19.40 0.757 2.00E−05 0.002 ADCY10 adenylate cyclase 10 (soluble) Cytoplasm enzyme

NM_001038704 -24.36 1.918 1.85E−05 0.002 C17orf47 chromosome 17 open reading frame 47 unknown other

NR_024337 -21.13 −0.858 1.90E−05 0.002 C1orf133 chromosome 1 open reading frame 133 unknown other

NM_207322 -24.31 1.799 1.85E−05 0.002 C2CD4A C2 calcium-dependent domain containing 4A unknown other

NR_034063 -23.13 −1.542 1.42E−05 0.002 D CASP12 caspase 12 (gene/pseudogene) Cytoplasm enzyme Extracellular NM_002981 -23.62 1.551 1.38E−05 0.002 CCL1 chemokine (C-C motif) ligand 1 Space cytokine cysteine-rich secretory protein LCCL domain NM_031461 -17.64 0.697 1.40E−05 0.002 CRISPLD1 containing 1 unknown other transcription NM_001079675 -20.79 −0.868 1.39E−05 0.002 ETV4 ets variant 4 Nucleus regulator transcription NM_001986 -20.79 −0.868 1.39E−05 0.002 ETV4 ets variant 4 Nucleus regulator NM_001099951 -23.85 −2.015 1.54E−05 D FAM166B family with sequence similarity 166, member unknown other

168 0.002 B

NM_031950 -24.23 −2.057 1.62E−05 0.002 FGFBP2 fibroblast growth factor binding protein 2 Extracellular Space other G-protein coupled NM_001193306 -20.05 0.787 1.49E−05 0.002 FPR1 formyl peptide receptor 1 Plasma Membrane receptor

NM_000558 -17.98 0.705 1.89E−05 0.002 HBA1/HBA2 hemoglobin, alpha 1 Cytoplasm transporter HIST1H3A (includes NM_003533 -24.51 −2.504 1.60E−05 0.002 D others) histone cluster 1, H3a Nucleus other

major histocompatibility complex, class II, transmembrane NM_002122 -21.22 −0.875 2.01E−05 0.002 HLA-DQA1 DQ alpha 1 Plasma Membrane receptor potassium inwardly-rectifying channel, NM_002243 -23.99 1.819 1.37E−05 0.002 D KCNJ15 subfamily J, member 15 Plasma Membrane ion channel potassium inwardly-rectifying channel, NM_170736 -23.99 1.819 1.37E−05 0.002 D KCNJ15 subfamily J, member 15 Plasma Membrane ion channel

LOC1005073 NR_037891 -37.34 25.350 1.26E−05 0.002 91 hypothetical LOC100507391 unknown other

NR_027927 -23.45 1.435 1.29E−05 0.002 LOC344875 collagen, type VI, alpha 4 pseudogene 1 unknown other

NR_029975 -25.99 3.805 1.21E−05 0.002 D mir-154 microRNA 656 unknown microRNA

NR_036072 -24.03 1.748 1.34E−05 0.002 MIR3125 microRNA 3125 unknown microRNA

NCRNA0029 NR_027286 -20.63 −0.856 1.73E−05 0.002 2 non-protein coding RNA 292 unknown other transcription NM_178864 -18.68 0.703 1.68E−05 0.002 NPAS4 neuronal PAS domain protein 4 Nucleus regulator pleckstrin homology domain containing, NM_052909 -22.02 1.108 1.48E−05 0.002 PLEKHG4B family G (with RhoGef domain) member 4B unknown other pro-platelet basic protein (chemokine (C- Extracellular NM_002704 -23.71 1.836 1.42E−05 0.002 PPBP X-C motif) ligand 7) Space cytokine

NR_003056 -13.32 −0.665 1.75E−05 0.002 SNORD67 small nucleolar RNA, C/D box 67 unknown other transcription NM_022454 -21.75 1.030 1.52E−05 0.002 SOX17 SRY (sex determining region Y)-box 17 Nucleus regulator

NM_001017970 -21.38 0.887 1.56E−05 0.002 TMEM30B transmembrane protein 30B unknown other 169

NR_034064 -23.27 −1.541 2.24E−05 0.003 D CASP12 caspase 12 (gene/pseudogene) Cytoplasm enzyme

NM_021233 -22.56 1.175 2.69E−05 0.003 D DNASE2B deoxyribonuclease II beta Cytoplasm enzyme G-protein coupled NM_000797 -23.79 1.663 2.60E−05 0.003 DRD4 dopamine receptor D4 Plasma Membrane receptor excision repair cross-complementing rodent repair deficiency, complementation NM_017669 -26.15 3.487 2.21E−05 0.003 ERCC6L group 6-like Nucleus other

NR_003246 -23.83 1.628 2.73E−05 0.003 FLJ40113 golgin A6 family-like 5 (pseudogene) unknown other

NR_034162 -37.41 25.215 2.39E−05 0.003 FLJ43879 FLJ43879 protein unknown other potassium inwardly-rectifying channel, NM_170737 -24.01 1.776 2.86E−05 0.003 D KCNJ15 subfamily J, member 15 Plasma Membrane ion channel NmrA-like family domain containing 1 NR_033752 -24.85 −2.250 3.02E−05 0.003 LOC344887 pseudogene unknown other

NR_030411 -37.49 −25.052 2.80E−05 0.003 mir-454 microRNA 454 unknown microRNA

NR_030378 -23.28 −1.435 2.80E−05 0.003 mir-648 microRNA 648 unknown microRNA

NM_176870 -18.47 0.698 3.00E−05 0.003 MT1M metallothionein 1M unknown other

NM_016817 -18.22 −0.685 2.26E−05 0.003 OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa Cytoplasm enzyme G-protein olfactory receptor, family 2, subfamily K, coupled NM_205859 -37.54 −24.954 2.80E−05 0.003 OR2K2 member 2 Plasma Membrane receptor SNORD115- NR_003355 -18.00 0.695 2.83E−05 0.003 40 small nucleolar RNA, C/D box 115-40 unknown other

NM_001078 -18.83 −0.709 2.85E−05 0.003 VCAM1 vascular cell adhesion molecule 1 Plasma Membrane other

NM_031951 -25.28 2.592 2.23E−05 0.003 WDR87 WD repeat domain 87 unknown other

NM_001037162 -24.70 −2.179 3.54E−05 0.004 ACOT6 acyl-CoA thioesterase 6 Cytoplasm enzyme

NM_001191016 -22.75 −1.252 3.14E−05 0.004 D CASP12 caspase 12 (gene/pseudogene) Cytoplasm enzyme

NM_004368 -20.75 0.784 4.17E−05 0.004 CNN2 calponin 2 Cytoplasm other NM_003650 -23.48 −1.411 3.24E−05 CST7 cystatin F (leukocystatin) Extracellular Space other

170 0.004

NM_001029955 -20.52 0.800 3.35E−05 0.004 DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 unknown other

NM_002354 -19.58 0.714 3.80E−05 0.004 EPCAM epithelial cell adhesion molecule Plasma Membrane other family with sequence similarity 83, member NM_178468 -26.82 4.152 3.68E−05 0.004 FAM83C C unknown other transcription NM_005269 -21.55 −0.962 3.77E−05 0.004 GLI1 GLI family zinc finger 1 Nucleus regulator G-protein coupled NM_021624 -23.47 1.481 3.26E−05 0.004 D HRH4 histamine receptor H4 Plasma Membrane receptor

transmembrane NM_000877 -18.10 0.679 3.52E−05 0.004 IL1R1 interleukin 1 receptor, type I Plasma Membrane receptor

NM_030615 -21.52 0.941 3.60E−05 0.004 KIF25 kinesin family member 25 Cytoplasm other

LOC1002872 NR_029193 -22.67 1.075 3.33E−05 0.004 16 hypothetical LOC100287216 unknown other

NR_033880 -20.94 −0.824 3.32E−05 0.004 LOC339822 hypothetical LOC339822 unknown other family with sequence similarity 157, member NM_001145248 -23.64 1.458 3.60E−05 0.004 LOC728262 A unknown other

NM_139021 -22.55 −1.211 4.00E−05 0.004 MAPK15 mitogen-activated protein kinase 15 Cytoplasm kinase

NR_036205 -24.69 −2.196 3.44E−05 0.004 MIR4317 microRNA 4317 unknown microRNA

transmembrane NM_001145466 -26.16 3.484 3.84E−05 0.004 D NCR3 natural cytotoxicity triggering receptor 3 Plasma Membrane receptor

transmembrane NM_147130 -26.16 3.484 3.84E−05 0.004 D NCR3 natural cytotoxicity triggering receptor 3 Plasma Membrane receptor G-protein olfactory receptor, family 52, subfamily B, coupled NM_001005161 -26.79 4.203 3.68E−05 0.004 OR52B4 member 4 Plasma Membrane receptor transcription NM_001754 -19.53 0.736 3.47E−05 0.004 RUNX1 runt-related transcription factor 1 Nucleus regulator serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), NM_001165413 -19.84 0.709 4.18E−05 0.004 SERPINE1 member 1 Extracellular Space other

171 small nucleolar RNA, H/ACA box 70C NR_003708 -23.27 1.238 3.76E−05 0.004 SNORA70C (retrotransposed) unknown other

NM_003246 -16.97 0.658 3.82E−05 0.004 THBS1 thrombospondin 1 Extracellular Space other

NM_030824 -19.18 0.688 3.25E−05 0.004 ZNF442 zinc finger protein 442 Nucleus other G-protein coupled NM_000682 -21.75 0.896 5.06E−05 0.005 ADRA2B adrenergic, alpha-2B-, receptor Plasma Membrane receptor G-protein coupled NM_000685 -23.29 −1.227 5.70E−05 0.005 D AGTR1 angiotensin II receptor, type 1 Plasma Membrane receptor G-protein coupled NM_004835 -23.29 −1.227 5.70E−05 0.005 D AGTR1 angiotensin II receptor, type 1 Plasma Membrane receptor G-protein coupled NM_009585 -23.29 −1.227 5.70E−05 0.005 D AGTR1 angiotensin II receptor, type 1 Plasma Membrane receptor G-protein coupled NM_031850 -23.29 −1.227 5.70E−05 0.005 D AGTR1 angiotensin II receptor, type 1 Plasma Membrane receptor G-protein coupled NM_032049 -23.29 −1.227 5.70E−05 0.005 D AGTR1 angiotensin II receptor, type 1 Plasma Membrane receptor

NM_001039775 -37.50 −25.023 5.52E−05 0.005 AIM1L absent in melanoma 1-like unknown other

NR_023925 -23.34 1.569 4.46E−05 0.005 D C18orf2 chromosome 18 open reading frame 2 unknown other cell division cycle 20 homolog B (S. NM_152623 -37.41 25.204 4.55E−05 0.005 D CDC20B cerevisiae) unknown other Extracellular NM_000639 -37.44 25.145 4.55E−05 0.005 FASLG Fas ligand (TNF superfamily, member 6) Space cytokine

Fc fragment of IgG, high affinity Ia, transmembra NM_000566 -23.67 1.458 5.15E−05 0.005 FCGR1A receptor (CD64) Plasma Membrane ne receptor growth arrest and DNA-damage-inducible, NM_015675 -17.17 0.646 5.38E−05 0.005 GADD45B beta Cytoplasm other

NM_152779 -37.51 −25.018 5.52E−05 0.005 GLIPR1L1 GLI pathogenesis-related 1 like 1 unknown other

NR_033252 -20.63 0.775 5.32E−05 0.005 LOC145663 hypothetical LOC145663 unknown other NR_037866 -24.27 −2.150 5.03E−05 LOC641365 hypothetical LOC641365 unknown other

172 0.005

NR_037182 -20.09 0.768 5.70E−05 0.005 LOC653513 hypothetical LOC653513 unknown other G-protein melanocortin 2 receptor coupled NM_000529 -37.58 −24.864 5.52E−05 0.005 MC2R (adrenocorticotropic hormone) Plasma Membrane receptor

NR_029485 -37.42 25.191 4.55E−05 0.005 D mir-15 microRNA 16-1 unknown microRNA

NR_037517 -37.42 25.194 4.55E−05 0.005 D mir-548 microRNA 548c unknown microRNA

NM_207308 -20.89 −0.833 4.38E−05 0.005 NUP210L nucleoporin 210kDa-like unknown other

NM_001159484 -20.89 −0.825 4.83E−05 0.005 NUP210L nucleoporin 210kDa-like unknown other 6-phosphofructo-2-kinase/fructose-2,6- NM_002625 -21.79 −0.989 4.33E−05 0.005 PFKFB1 biphosphatase 1 Cytoplasm kinase

NM_178449 -37.49 25.053 4.55E−05 0.005 PTH2 parathyroid hormone 2 Extracellular Space other G-protein relaxin/insulin-like family peptide receptor coupled NM_001166058 -22.89 1.299 5.32E−05 0.005 D RXFP2 2 Plasma Membrane receptor

NM_001166035 -37.59 −24.842 5.52E−05 0.005 D SBSN suprabasin Cytoplasm other serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), NM_000602 -19.83 0.701 4.97E−05 0.005 SERPINE1 member 1 Extracellular Space other tumor necrosis factor receptor NM_001192 -37.50 −25.022 5.52E−05 0.005 TNFRSF17 superfamily, member 17 Plasma Membrane other

NM_181802 -37.52 25.000 4.55E−05 0.005 D UBE2C ubiquitin-conjugating enzyme E2C Cytoplasm enzyme

NM_001045476 -25.53 2.728 4.65E−05 0.005 WDR38 WD repeat domain 38 unknown other

NM_152694 -25.71 −3.316 4.76E−05 0.005 ZCCHC5 zinc finger, CCHC domain containing 5 unknown other

NM_001080523 -23.03 −1.404 5.91E−05 0.006 ARRDC5 arrestin domain containing 5 unknown other

NM_001010863 -21.18 0.852 7.01E−05 0.006 C10orf128 chromosome 10 open reading frame 128 unknown other

NM_178550 -20.45 −0.750 6.10E−05 0.006 C1orf110 chromosome 1 open reading frame 110 unknown other

NM_152770 -20.85 −0.753 6.55E−05 0.006 C4orf22 chromosome 4 open reading frame 22 unknown other

173

NR_034068 -25.81 −3.124 6.13E−05 0.006 D CASP12 caspase 12 (gene/pseudogene) Cytoplasm enzyme

NM_001166624 -26.12 3.543 6.67E−05 0.006 D CFHR3 complement factor H-related 3 Extracellular Space other

NM_021023 -26.12 3.543 6.67E−05 0.006 D CFHR3 complement factor H-related 3 Extracellular Space other

NM_001190986 -25.47 −2.956 5.87E−05 0.006 D CRISP3 cysteine-rich secretory protein 3 Extracellular Space other

NM_006061 -25.47 −2.956 5.87E−05 0.006 D CRISP3 cysteine-rich secretory protein 3 Extracellular Space other transcription NM_005438 -24.17 1.654 5.93E−05 0.006 FOSL1 FOS-like antigen 1 Nucleus regulator

NM_002150 -26.24 3.308 6.67E−05 0.006 D HPD 4-hydroxyphenylpyruvate dioxygenase Cytoplasm enzyme

NM_199440 -14.93 0.625 6.23E−05 0.006 HSPD1 heat shock 60kDa protein 1 (chaperonin) Cytoplasm enzyme

NM_002156 -14.93 0.625 6.37E−05 0.006 HSPD1 heat shock 60kDa protein 1 (chaperonin) Cytoplasm enzyme

NR_036085 -25.06 −2.209 6.81E−05 0.006 MIR3134 microRNA 3134 unknown microRNA

transmembrane NM_001145467 -26.19 3.420 6.67E−05 0.006 D NCR3 natural cytotoxicity triggering receptor 3 Plasma Membrane receptor

NCRNA0029 NR_027285 -20.31 −0.774 7.05E−05 0.006 2 non-protein coding RNA 292 unknown other G-protein olfactory receptor, family 8, subfamily D, coupled NM_001002917 -26.74 4.303 6.63E−05 0.006 OR8D1 member 1 Plasma Membrane receptor G-protein coupled NM_130806 -22.83 1.279 5.88E−05 0.006 D RXFP2 relaxin/insulin-like family peptide receptor 2 Plasma Membrane receptor

NM_006142 -23.45 1.129 7.15E−05 0.006 SFN stratifin Cytoplasm other

NM_206885 -24.40 1.818 6.04E−05 0.006 D SLC26A5 solute carrier family 26, member 5 (prestin) Plasma Membrane transporter

NM_206884 -23.68 1.496 6.78E−05 0.006 D SLC26A5 solute carrier family 26, member 5 (prestin) Plasma Membrane transporter

NM_080682 -18.93 −0.683 5.91E−05 0.006 VCAM1 vascular cell adhesion molecule 1 Plasma Membrane other

NM_182572 -20.90 −0.787 6.34E−05 0.006 ZSCAN1 zinc finger and SCAN domain containing 1 Nucleus other

174

NM_080833 -22.81 −1.312 7.56E−05 0.007 C20orf151 chromosome 20 open reading frame 151 unknown other leukocyte immunoglobulin-like receptor, NM_006865 -26.85 −4.232 7.64E−05 0.007 D LILRA3 subfamily A (without TM domain), member 3 Extracellular Space other G-protein olfactory receptor, family 52, subfamily K, coupled NM_001005171 -26.82 −4.286 7.64E−05 0.007 OR52K1 member 1 Plasma Membrane receptor

NM_013270 -23.78 1.465 7.73E−05 0.007 PRSS50 protease, serine, 50 Cytoplasm peptidase

NM_023004 -17.31 −0.631 7.38E−05 0.007 RTN4R reticulon 4 receptor Plasma Membrane other

transmembrane NM_000361 -20.07 0.748 7.83E−05 0.007 THBD thrombomodulin Plasma Membrane receptor

NM_001199834 -18.97 −0.674 8.06E−05 0.007 VCAM1 vascular cell adhesion molecule 1 Plasma Membrane other

NM_001170633 -37.49 25.047 8.66E−05 0.008 D C12orf56 chromosome 12 open reading frame 56 unknown other

NM_175940 -21.55 −0.937 8.78E−05 0.008 DUOX1 dual oxidase 1 Plasma Membrane enzyme potassium large conductance calcium- activated channel, subfamily M, beta member NM_004137 -22.18 −0.949 9.30E−05 0.008 KCNMB1 1 Plasma Membrane ion channel myosin, heavy chain 1, skeletal muscle, NM_005963 -23.56 1.515 8.69E−05 0.008 MYH1 adult Cytoplasm enzyme

NM_002852 -21.32 0.792 9.49E−05 0.008 PTX3 pentraxin 3, long Extracellular Space other

NM_175769 -37.50 25.034 8.66E−05 0.008 TCF23 transcription factor 23 Nucleus other

NM_024786 -20.54 0.757 9.66E−05 0.008 ZDHHC11 zinc finger, DHHC-type containing 11 unknown other

NM_001013663 -18.13 0.640 1.03E−04 0.009 C2orf79 chromosome 2 open reading frame 79 unknown other

NM_019609 -23.29 −1.571 1.05E−04 0.009 D CPXM1 carboxypeptidase X (M14 family), member 1 Extracellular Space peptidase

NM_017434 -21.40 −0.912 1.10E−04 0.009 DUOX1 dual oxidase 1 Plasma Membrane enzyme family with sequence similarity 166, member NM_001164310 -23.73 −1.802 9.89E−05 0.009 D FAM166B B unknown other transcription NM_001160045 -21.61 −0.903 1.12E−04 0.009 GLI1 GLI family zinc finger 1 Nucleus regulator NM_002108 -24.40 −1.923 1.15E−04 HAL histidine ammonia-lyase Cytoplasm enzyme 175 0.009

NR_034099 -22.95 −1.172 1.15E−04 0.009 LOC388948 hypothetical LOC388948 unknown other

NR_034133 -25.64 −2.654 1.06E−04 0.009 LOC400655 hypothetical LOC400655 unknown other

NM_006439 -25.18 −2.390 1.10E−04 0.009 MAB21L2 mab-21-like 2 (C. elegans) Nucleus other

NR_030357 -37.60 −24.839 1.09E−04 0.009 mir-627 microRNA 627 unknown microRNA

NR_036074 -37.51 −25.014 1.09E−04 0.009 MIR3127 microRNA 3127 unknown microRNA

NM_001135092 -23.82 1.670 1.03E−04 0.009 D MUC15 mucin 15, cell surface associated Extracellular Space other

NM_017433 -21.69 0.946 1.08E−04 0.009 MYO3A myosin IIIA Cytoplasm kinase oligonucleotide/oligosaccharide-binding fold NM_001031716 -18.54 0.638 1.14E−04 0.009 OBFC2A containing 2A Nucleus other G-protein olfactory receptor, family 13, subfamily C, coupled NM_001001919 -22.78 −0.984 1.11E−04 0.009 OR13C4 member 4 Plasma Membrane receptor protein tyrosine phosphatase, receptor NM_080923 -23.20 1.376 1.09E−04 0.009 D PTPRC type, C Plasma Membrane phosphatase

NM_052934 -20.29 0.743 1.01E−04 0.009 SLC26A9 solute carrier family 26, member 9 Plasma Membrane transporter solute carrier family 27 (fatty acid NM_014031 -19.71 0.731 1.14E−04 0.009 SLC27A6 transporter), member 6 Plasma Membrane transporter

NM_001093728 -21.95 −1.005 1.14E−04 0.009 D TCP11 t-complex 11 homolog (mouse) unknown other G-protein coupled NM_000678 -19.28 −0.657 1.20E−04 0.010 ADRA1D adrenergic, alpha-1D-, receptor Plasma Membrane receptor activity-regulated cytoskeleton-associated NM_015193 -16.85 −0.610 1.21E−04 0.010 ARC protein Cytoplasm other

NR_023926 -23.36 1.526 1.36E−04 0.010 D C18orf2 chromosome 18 open reading frame 2 unknown other

NR_023928 -23.36 1.526 1.36E−04 0.010 D C18orf2 chromosome 18 open reading frame 2 unknown other

NM_001013625 -22.53 0.967 1.29E−04 0.010 C1orf192 chromosome 1 open reading frame 192 unknown other

NM_014289 -25.54 2.693 1.25E−04 0.010 CAPN6 calpain 6 Cytoplasm peptidase

176

transmembrane NM_203416 -18.17 0.605 1.34E−04 0.010 CD163 CD163 molecule Plasma Membrane receptor

transmembrane NM_004244 -18.17 0.605 1.35E−04 0.010 CD163 CD163 molecule Plasma Membrane receptor

transmembrane NM_001781 -22.38 −0.890 1.29E−04 0.010 CD69 CD69 molecule Plasma Membrane receptor family with sequence similarity 177, member NM_207468 -24.82 2.136 1.25E−04 0.010 FAM177B B unknown other

NM_005838 -23.84 1.745 1.36E−04 0.010 D GLYAT glycine-N-acyltransferase Cytoplasm enzyme G-protein coupled NM_013308 -24.30 1.787 1.29E−04 0.010 GPR171 G protein-coupled receptor 171 Plasma Membrane receptor

NM_001135111 -25.11 −2.518 1.19E−04 0.010 D KCNK17 potassium channel, subfamily K, member 17 Plasma Membrane ion channel

NM_031460 -25.11 −2.518 1.19E−04 0.010 D KCNK17 potassium channel, subfamily K, member 17 Plasma Membrane ion channel

NM_005577 -21.75 −0.919 1.18E−04 0.010 LPA lipoprotein, Lp(a) Extracellular Space other

NM_005925 -22.70 1.067 1.19E−04 0.010 MEP1B meprin A, beta Plasma Membrane peptidase

NR_036055 -26.37 −3.201 1.31E−04 0.010 mir-2861 microRNA 2861 unknown microRNA NADH dehydrogenase (ubiquinone) 1 alpha NM_005000 -15.15 0.601 1.24E−04 0.010 NDUFA5 subcomplex, 5, 13kDa Cytoplasm enzyme transcription NM_004688 -19.78 0.731 1.17E−04 0.010 NMI N-myc (and STAT) interactor Cytoplasm regulator preferentially expressed antigen in NM_006115 -26.84 4.119 1.20E−04 0.010 D PRAME melanoma Nucleus other preferentially expressed antigen in NM_206953 -26.84 4.119 1.20E−04 0.010 D PRAME melanoma Nucleus other preferentially expressed antigen in NM_206954 -26.84 4.119 1.20E−04 0.010 D PRAME melanoma Nucleus other preferentially expressed antigen in NM_206955 -26.84 4.119 1.20E−04 0.010 D PRAME melanoma Nucleus other preferentially expressed antigen in NM_206956 -26.84 4.119 1.20E−04 0.010 D PRAME melanoma Nucleus other

NM_002965 -18.97 0.635 1.33E−04 0.010 S100A9 S100 calcium binding protein A9 Cytoplasm other

177

NM_001039508 -24.59 1.959 1.33E−04 0.010 D SIRPG signal-regulatory protein gamma Plasma Membrane other X-prolyl aminopeptidase (aminopeptidase P) NM_003399 -25.78 −3.175 1.35E−04 0.010 XPNPEP2 2, membrane-bound Plasma Membrane peptidase

NR_023927 -23.53 1.531 1.38E−04 0.011 D C18orf2 chromosome 18 open reading frame 2 unknown other cell division cycle 20 homolog (S. NM_001255 -23.08 −1.098 1.40E−04 0.011 CDC20 cerevisiae) Nucleus other transcription NM_032110 -21.91 0.984 1.47E−04 0.011 DMRTA2 DMRT-like family A2 Nucleus regulator

NM_033266 -26.88 −4.159 1.42E−04 0.011 ERN2 endoplasmic reticulum to nucleus signaling 2 Cytoplasm kinase

NR_024021 -25.71 3.168 1.48E−04 0.011 hCG 33730 ACYL3 pseudogene unknown other

NM_012278 -21.86 0.903 1.38E−04 0.011 ITGB1BP2 integrin beta 1 binding protein (melusin) 2 unknown other

LOC1001339 NR_028119 -22.88 1.015 1.40E−04 0.011 D 57 hypothetical LOC100133957 unknown other transcription NM_000971 -22.11 1.019 1.45E−04 0.011 RPL7 ribosomal protein L7 Cytoplasm regulator transcription NM_017420 -18.08 0.616 1.52E−04 0.011 SIX4 SIX homeobox 4 Nucleus regulator SNORD115- NR_003362 -16.06 0.602 1.37E−04 0.011 48 small nucleolar RNA, C/D box 115-48 unknown other

NR_003036 -18.29 0.634 1.48E−04 0.011 SNORD6 small nucleolar RNA, C/D box 6 unknown other BCL2/adenovirus E1B 19kD interacting NM_001159642 -21.70 0.913 1.59E−04 0.012 BNIPL protein like Cytoplasm other

NM_001778 -22.77 0.996 1.62E−04 0.012 CD48 CD48 molecule Plasma Membrane other

NM_001204744 -37.62 24.795 1.66E−04 0.012 D CDH16 cadherin 16, KSP-cadherin Plasma Membrane enzyme

NM_001204745 -37.62 24.795 1.66E−04 0.012 D CDH16 cadherin 16, KSP-cadherin Plasma Membrane enzyme

NM_004062 -37.62 24.795 1.66E−04 0.012 D CDH16 cadherin 16, KSP-cadherin Plasma Membrane enzyme

NM_001845 -17.46 0.607 1.73E−04 0.012 COL4A1 collagen, type IV, alpha 1 Extracellular Space other family with sequence similarity 194, member NM_182542 -23.46 1.262 1.71E−04 0.012 FAM194B B unknown other NR_024377 -19.71 0.699 1.56E−04 FER1L4 fer-1-like 4 (C. elegans) pseudogene unknown other

178 0.012 transcription NM_001167609 -21.61 −0.890 1.69E−04 0.012 GLI1 GLI family zinc finger 1 Nucleus regulator

NM_018891 -22.17 −0.966 1.64E−04 0.012 LAMC2 laminin, gamma 2 Extracellular Space other

NM_001195082 -21.77 0.830 1.57E−04 0.012 LOC647310 testis expressed gene 22 Cytoplasm other

NR_036117 -37.59 24.856 1.66E−04 0.012 mir-3160 unknown microRNA MAP kinase interacting serine/threonine NM_017572 -16.88 0.600 1.57E−04 0.012 MKNK2 kinase 2 Cytoplasm kinase

transmembrane NM_002507 -20.38 0.678 1.60E−04 0.012 NGFR nerve growth factor receptor Plasma Membrane receptor G-protein olfactory receptor, family 2, subfamily AT, coupled NM_001005285 -37.62 24.789 1.66E−04 0.012 OR2AT4 member 4 Plasma Membrane receptor

NM_004199 -17.08 0.600 1.55E−04 0.012 P4HA2 prolyl 4-hydroxylase, alpha polypeptide II Cytoplasm enzyme SH3 domain binding glutamic acid-rich NM_007341 -17.24 0.606 1.57E−04 0.012 SH3BGR protein Cytoplasm other solute carrier family 22 (organic anion NM_006672 -22.72 1.026 1.69E−04 0.012 D SLC22A7 transporter), member 7 Plasma Membrane transporter solute carrier family 22 (organic anion NM_153320 -22.72 1.026 1.69E−04 0.012 D SLC22A7 transporter), member 7 Plasma Membrane transporter

NM_134325 -20.32 0.713 1.70E−04 0.012 SLC26A9 solute carrier family 26, member 9 Plasma Membrane transporter SNORD114- NR_003220 -23.59 −1.533 1.60E−04 0.012 27 small nucleolar RNA, C/D box 114-27 unknown other SNORD115- NR_001291 -18.75 0.620 1.67E−04 0.012 1 small nucleolar RNA, C/D box 115-1 unknown other SNORD115- NR_003345 -14.81 0.588 1.72E−04 0.012 30 small nucleolar RNA, C/D box 115-30 unknown other

NM_001013641 -37.62 24.795 1.66E−04 0.012 TMEM82 transmembrane protein 82 unknown other

NM_181801 -37.62 24.788 1.66E−04 0.012 D UBE2C ubiquitin-conjugating enzyme E2C Cytoplasm enzyme transcription NM_033113 -21.85 −0.887 1.65E−04 0.012 ZNF628 zinc finger protein 628 Nucleus regulator

NM_003813 -22.08 1.003 1.89E−04 0.013 ADAM21 ADAM metallopeptidase domain 21 Plasma Membrane peptidase

179

NM_178181 -22.76 −1.237 1.93E−04 0.013 D CDCP1 CUB domain containing protein 1 Plasma Membrane other

NR_028342 -24.96 1.891 1.80E−04 0.013 LOC285501 hypothetical LOC285501 unknown other

NR_027117 -25.88 −2.998 1.83E−04 0.013 LOC285847 hypothetical LOC285847 unknown other membrane-spanning 4-domains, subfamily NM_021950 -24.59 −2.066 1.84E−04 0.013 D MS4A1 A, member 1 Plasma Membrane other membrane-spanning 4-domains, subfamily NM_152866 -24.59 −2.066 1.84E−04 0.013 D MS4A1 A, member 1 Plasma Membrane other transcription NM_001146312 -19.70 0.659 1.84E−04 0.013 MYOCD myocardin Nucleus regulator

NM_198213 -22.36 −0.984 1.76E−04 0.013 OASL 2'-5'-oligoadenylate synthetase-like Cytoplasm enzyme oligonucleotide/oligosaccharide-binding fold NR_024415 -18.61 0.620 1.78E−04 0.013 OBFC2A containing 2A Nucleus other

NM_174910 -25.04 2.516 1.80E−04 0.013 TCTE3 t-complex-associated-testis-expressed 3 Plasma Membrane other carbohydrate (chondroitin 6) sulfotransferase NM_004273 -16.11 0.583 2.07E−04 0.014 CHST3 3 Cytoplasm enzyme

NM_201277 -20.91 0.718 2.11E−04 0.014 CNN2 calponin 2 Cytoplasm other

NR_002770 -23.39 1.319 2.10E−04 0.014 DIO3OS DIO3 opposite strand (non-protein coding) unknown other

NM_000128 -22.61 −0.964 2.02E−04 0.014 F11 coagulation factor XI Extracellular Space peptidase

NM_005527 -17.70 0.598 2.09E−04 0.014 HSPA1L heat shock 70kDa protein 1-like Cytoplasm other

LOC1001342 NR_024452 -20.26 −0.717 1.95E−04 0.014 59 similar to hCG1987718 unknown other

NM_003006 -18.16 −0.606 1.98E−04 0.014 SELPLG selectin P ligand Plasma Membrane other

NM_182538 -23.39 −1.315 1.96E−04 0.014 SPNS3 spinster homolog 3 (Drosophila) unknown other ADAM metallopeptidase with NM_030955 -21.37 0.803 2.19E−04 0.015 ADAMTS12 thrombospondin type 1 motif, 12 Extracellular Space peptidase

ALPP/ALPP NM_001632 -26.87 4.040 2.16E−04 0.015 L2 alkaline phosphatase, placental Plasma Membrane phosphatase complement component (3b/4b) receptor 1- NM_175710 -37.61 −24.813 2.17E−04 0.015 CR1L like Plasma Membrane other

180

LOC1001321 NM_001195442 -37.61 −24.816 2.17E−04 0.015 46 hypothetical LOC100132146 unknown other

NR_029510 -37.71 −24.615 2.17E−04 0.015 D mir-17 microRNA 106a unknown microRNA

NR_031641 -23.94 1.593 2.23E−04 0.015 MIR1243 microRNA 1243 unknown microRNA transcription NM_153604 -19.72 0.654 2.17E−04 0.015 MYOCD myocardin Nucleus regulator

NR_002975 -16.91 0.585 2.19E−04 0.015 SNORA43 small nucleolar RNA, H/ACA box 43 unknown other transcription NM_014588 -20.60 0.737 2.28E−04 0.015 D VSX1 visual system homeobox 1 Nucleus regulator

NM_182592 -21.24 −0.839 2.28E−04 0.015 YIPF7 Yip1 domain family, member 7 unknown other

NR_026860 -17.58 −0.586 2.33E−04 0.016 C6orf176 chromosome 6 open reading frame 176 unknown other cytochrome P450, family 24, subfamily A, NM_000782 -20.49 0.721 2.32E−04 0.016 CYP24A1 polypeptide 1 Cytoplasm enzyme

NM_001129895 -25.36 2.420 2.37E−04 0.016 HGC6.3 hypothetical LOC100128124 unknown other

NM_002301 -23.25 1.375 2.39E−04 0.016 D LDHC lactate dehydrogenase C Cytoplasm enzyme

NM_138441 -20.80 0.731 2.48E−04 0.016 MB21D1 Mab-21 domain containing 1 unknown other v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) NR_026766 -23.66 −1.239 2.34E−04 0.016 MYCNOS opposite strand unknown other

NR_002588 -14.35 0.571 2.48E−04 0.016 SNORA4 small nucleolar RNA, H/ACA box 4 unknown other

NM_001166692 -22.67 1.105 2.51E−04 0.017 C11orf91 chromosome 11 open reading frame 91 unknown other

NM_001163561 -21.83 −0.927 2.50E−04 0.017 C2orf61 chromosome 2 open reading frame 61 unknown other

NM_000610 -16.37 0.574 2.57E−04 0.017 CD44 CD44 molecule (Indian blood group) Plasma Membrane other

NM_001001389 -16.37 0.574 2.61E−04 0.017 CD44 CD44 molecule (Indian blood group) Plasma Membrane other Extracellular NM_001868 -26.93 −4.059 2.66E−04 0.017 CPA1 carboxypeptidase A1 (pancreatic) Space peptidase

NM_201648 -23.07 1.153 2.61E−04 0.017 D GLYAT glycine-N-acyltransferase Cytoplasm enzyme

181 G-protein coupled NM_005284 -20.71 0.708 2.63E−04 0.017 GPR6 G protein-coupled receptor 6 Plasma Membrane receptor

NM_005588 -25.03 2.114 2.62E−04 0.017 MEP1A meprin A, alpha (PABA peptide hydrolase) Plasma Membrane peptidase

NR_036197 -22.10 0.964 2.62E−04 0.017 MIR4312 microRNA 4312 unknown microRNA

NM_001017973 -17.09 0.579 2.59E−04 0.017 P4HA2 prolyl 4-hydroxylase, alpha polypeptide II Cytoplasm enzyme

NR_034066 -24.53 −1.724 2.88E−04 0.018 D CASP12 caspase 12 (gene/pseudogene) Cytoplasm enzyme

NM_001237 -19.14 0.617 2.77E−04 0.018 CCNA2 cyclin A2 Nucleus other

NM_002014 -13.87 0.565 2.83E−04 0.018 FKBP4 FK506 binding protein 4, 59kDa Nucleus enzyme

NR_034147 -22.81 −1.091 2.75E−04 0.018 LOC149773 hypothetical LOC149773 unknown other

NR_037597 -25.89 2.817 2.74E−04 0.018 LOC442028 hypothetical LOC442028 unknown other

NM_003733 -22.22 −0.921 2.82E−04 0.018 OASL 2'-5'-oligoadenylate synthetase-like Cytoplasm enzyme

NM_000531 -23.23 1.186 2.82E−04 0.018 OTC ornithine carbamoyltransferase Cytoplasm enzyme

NM_001135844 -19.27 −0.612 2.77E−04 0.018 SIRPB1 signal-regulatory protein beta 1 Plasma Membrane other tubulin polymerization-promoting protein NM_173846 -24.69 −1.885 2.88E−04 0.018 TPPP2 family member 2 unknown other

NM_000035 -22.72 1.228 3.08E−04 0.019 ALDOB aldolase B, fructose-bisphosphate Cytoplasm enzyme

NM_001001392 -16.75 0.571 2.94E−04 0.019 CD44 CD44 molecule (Indian blood group) Plasma Membrane other

NM_014475 -21.66 0.791 3.05E−04 0.019 DHDH dihydrodiol dehydrogenase (dimeric) unknown enzyme

NM_018655 -24.57 1.727 2.93E−04 0.019 LENEP lens epithelial protein Cytoplasm other

LOC1002926 NR_028415 -23.47 1.249 3.02E−04 0.019 80 hypothetical LOC100292680 unknown other

NM_001080460 -21.45 0.801 3.02E−04 0.019 LRRIQ4 leucine-rich repeats and IQ motif containing 4 unknown other transcription NM_005924 -21.22 0.770 3.05E−04 0.019 MEOX2 mesenchyme homeobox 2 Nucleus regulator

182

NR_003026 -21.56 −0.920 2.94E−04 0.019 SNORA1 small nucleolar RNA, H/ACA box 1 unknown other

NM_018679 -22.05 −0.976 2.94E−04 0.019 D TCP11 t-complex 11 homolog (mouse) unknown other

NM_001001791 -37.58 24.863 3.17E−04 0.020 C10orf55 chromosome 10 open reading frame 55 unknown other

NM_001037331 -37.69 24.645 3.17E−04 0.020 C18orf62 chromosome 18 open reading frame 62 unknown other

NM_001202556 -16.43 0.565 3.22E−04 0.020 CD44 CD44 molecule (Indian blood group) Plasma Membrane other

NM_032855 -22.61 −1.105 3.20E−04 0.020 HSH2D hematopoietic SH2 domain containing Cytoplasm other

NR_030380 -37.59 24.851 3.17E−04 0.020 mir-651 microRNA 651 unknown microRNA

NM_001135091 -23.68 1.401 3.27E−04 0.020 D MUC15 mucin 15, cell surface associated Extracellular Space other

NM_145650 -23.68 1.401 3.27E−04 0.020 D MUC15 mucin 15, cell surface associated Extracellular Space other G-protein coupled NR_002713 -37.55 24.934 3.17E−04 0.020 NPY6R neuropeptide Y receptor Y6 (pseudogene) Plasma Membrane receptor G-protein olfactory receptor, family 14, subfamily C, coupled NM_001001918 -24.13 1.691 3.33E−04 0.020 OR14C36 member 36 Plasma Membrane receptor

NM_001002920 -37.55 24.941 3.17E−04 0.020 D POTEA POTE ankyrin domain family, member A unknown other

NM_001005365 -37.55 24.941 3.17E−04 0.020 D POTEA POTE ankyrin domain family, member A unknown other solute carrier family 27 (fatty acid NM_001017372 -19.64 0.676 3.24E−04 0.020 SLC27A6 transporter), member 6 Plasma Membrane transporter

NM_007019 -37.68 24.669 3.17E−04 0.020 D UBE2C ubiquitin-conjugating enzyme E2C Cytoplasm enzyme

NM_181800 -37.68 24.669 3.17E−04 0.020 D UBE2C ubiquitin-conjugating enzyme E2C Cytoplasm enzyme

NR_024621 -23.32 −1.292 3.39E−04 0.021 D C11orf21 chromosome 11 open reading frame 21 Cytoplasm other

NM_001001390 -16.40 0.563 3.40E−04 0.021 CD44 CD44 molecule (Indian blood group) Plasma Membrane other Kazal-type serine peptidase inhibitor domain NM_030929 -20.85 −0.709 3.39E−04 0.021 KAZALD1 1 Extracellular Space other

NM_001202555 -16.41 0.561 3.61E−04 0.022 CD44 CD44 molecule (Indian blood group) Plasma Membrane other

183

NM_001001391 -16.41 0.559 3.73E−04 0.022 CD44 CD44 molecule (Indian blood group) Plasma Membrane other cyclin-dependent kinase inhibitor 2A transcription NM_058197 -22.88 −1.157 3.64E−04 0.022 D CDKN2A (melanoma, p16, inhibits CDK4) Nucleus regulator

transmembra NM_022336 -25.72 −2.470 3.77E−04 0.022 EDAR ectodysplasin A receptor Plasma Membrane ne receptor UDP-N-acetyl-alpha-D- galactosamine:polypeptide N- acetylgalactosaminyltransferase 5 (GalNAc- NM_014568 -23.14 −1.109 3.54E−04 0.022 GALNT5 T5) Cytoplasm enzyme

transmembrane NM_001098479 -19.70 −0.650 3.69E−04 0.022 HLA-F major histocompatibility complex, class I, F Plasma Membrane receptor

NM_017878 -23.65 1.302 3.60E−04 0.022 HRASLS2 HRAS-like suppressor 2 unknown other

killer cell lectin-like receptor subfamily C, transmembra NM_213658 -23.20 1.271 3.66E−04 0.022 D KLRC1 member 1 Plasma Membrane ne receptor

NM_144612 -19.02 −0.600 3.71E−04 0.022 LOXHD1 lipoxygenase homology domains 1 Extracellular Space other

NM_016304 -16.29 0.564 3.59E−04 0.022 RSL24D1 ribosomal L24 domain containing 1 Nucleus other

NR_026678 -19.49 0.633 3.58E−04 0.022 TMEM79 transmembrane protein 79 unknown other

NM_001311 -20.99 −0.736 3.93E−04 0.023 CRIP1 cysteine-rich protein 1 (intestinal) Cytoplasm other

NM_001080836 -23.18 1.268 3.93E−04 0.023 MEIG1 meiosis expressed gene 1 homolog (mouse) Nucleus other

NR_030344 -26.92 3.938 3.90E−04 0.023 MIR613 microRNA 613 unknown microRNA MAP kinase interacting serine/threonine NM_199054 -16.32 0.559 3.91E−04 0.023 MKNK2 kinase 2 Cytoplasm kinase ligand- dependent nuclear receptor subfamily 4, group A, nuclear NM_002135 -16.40 −0.556 3.94E−04 0.023 NR4A1 member 1 Nucleus receptor transcription NM_006194 -26.96 3.855 3.90E−04 0.023 PAX9 paired box 9 Nucleus regulator transcription NM_144590 -23.66 1.256 4.10E−04 0.024 ANKRD22 ankyrin repeat domain 22 Nucleus regulator NM_001142946 -23.27 −1.226 4.02E−04 D C11orf21 chromosome 11 open reading frame 21 Cytoplasm other

184 0.024

NM_001103176 -21.43 0.756 4.07E−04 0.024 CNPY1 canopy 1 homolog (zebrafish) unknown other

NM_000494 -21.89 −0.867 4.11E−04 0.024 COL17A1 collagen, type XVII, alpha 1 Plasma Membrane other family with sequence similarity 182, member NR_026714 -20.46 0.710 4.13E−04 0.024 D FAM182B B unknown other HIST1H3A (includes NM_003531 -23.20 −1.085 4.02E−04 0.024 D others) histone cluster 1, H3a Nucleus other

killer cell lectin-like receptor subfamily C, transmembrane NM_002259 -23.41 1.330 4.02E−04 0.024 D KLRC1 member 1 Plasma Membrane receptor

NM_017448 -23.26 1.345 3.99E−04 0.024 D LDHC lactate dehydrogenase C Cytoplasm enzyme

LOC1002878 NR_033978 -22.50 1.010 4.11E−04 0.024 79 hypothetical LOC100287879 unknown other G-protein prostaglandin E receptor 1 (subtype EP1), coupled NM_000955 -25.24 2.141 4.09E−04 0.024 PTGER1 42kDa Plasma Membrane receptor solute carrier family 16, member 12 NM_213606 -21.07 0.705 4.02E−04 0.024 SLC16A12 (monocarboxylic acid transporter 12) unknown other

NM_001167962 -23.10 1.182 4.20E−04 0.024 D SLC26A5 solute carrier family 26, member 5 (prestin) Plasma Membrane transporter

NM_181538 -24.55 1.763 4.34E−04 0.025 GJC3 gap junction protein, gamma 3, 30.2kDa Extracellular Space transporter transcription NM_002147 -37.78 −24.478 4.31E−04 0.025 HOXB5 homeobox B5 Nucleus regulator

NR_029584 -22.27 0.940 4.40E−04 0.025 mir-198 microRNA 198 unknown microRNA ligand- dependent nuclear receptor subfamily 4, group A, nuclear NM_173157 -16.47 −0.552 4.37E−04 0.025 NR4A1 member 1 Nucleus receptor transcription NM_006192 -37.67 −24.690 4.31E−04 0.025 PAX1 paired box 1 Nucleus regulator

NR_024049 -24.78 1.904 4.49E−04 0.026 D BCAR4 breast cancer anti-estrogen resistance 4 unknown other

LOC1001317 NR_024479 -25.93 2.772 4.58E−04 0.026 26 HCC-related HCC-C11_v3 unknown other

185

NM_148896 -23.17 1.131 4.59E−04 0.026 NPB neuropeptide B Extracellular Space other

NM_013358 -25.25 −2.238 4.48E−04 0.026 PADI1 peptidyl arginine deiminase, type I Cytoplasm enzyme radial spoke head 9 homolog NM_001193341 -21.51 0.799 4.59E−04 0.026 RSPH9 (Chlamydomonas) unknown other SPRR2A (includes NM_001014291 -24.75 1.942 4.49E−04 0.026 others) small proline-rich protein 2A Cytoplasm other

NM_032525 -19.42 0.605 4.59E−04 0.026 TUBB6 tubulin, beta 6 Cytoplasm other

NM_152587 -21.25 0.787 4.92E−04 0.027 C11orf65 chromosome 11 open reading frame 65 unknown other

NR_026663 -27.02 −3.898 4.95E−04 0.027 C9orf70 chromosome 9 open reading frame 70 unknown other Extracellular NM_002416 -24.17 −1.627 4.87E−04 0.027 CXCL9 chemokine (C-X-C motif) ligand 9 Space cytokine cytochrome P450, family 24, subfamily A, NM_001128915 -20.66 0.699 4.93E−04 0.027 CYP24A1 polypeptide 1 Cytoplasm enzyme

NM_032372 -21.39 0.728 4.86E−04 0.027 DYDC2 DPY30 domain containing 2 unknown other

NM_005101 -18.93 −0.602 4.70E−04 0.027 ISG15 ISG15 ubiquitin-like modifier Extracellular Space other

killer cell lectin-like receptor subfamily C, transmembrane NM_213657 -23.21 1.256 4.70E−04 0.027 D KLRC1 member 1 Plasma Membrane receptor G-protein luteinizing hormone/choriogonadotropin coupled NM_000233 -22.99 1.073 4.87E−04 0.027 LHCGR receptor Plasma Membrane receptor

NR_031600 -26.98 −3.971 4.95E−04 0.027 mir-1234 microRNA 1234 unknown microRNA

NR_029689 -27.02 −3.876 4.95E−04 0.027 D mir-153 microRNA 153-2 unknown microRNA

NM_001077358 -21.97 0.852 4.87E−04 0.027 PDE11A phosphodiesterase 11A Cytoplasm enzyme

NM_000988 -15.93 0.548 4.93E−04 0.027 RPL27 ribosomal protein L27 Cytoplasm other ATP-binding cassette, sub-family C NM_033226 -17.83 −0.555 5.46E−04 0.029 ABCC12 (CFTR/MRP), member 12 Cytoplasm transporter ATP-binding cassette, sub-family C NM_000392 -20.59 0.704 5.22E−04 0.029 ABCC2 (CFTR/MRP), member 2 Plasma Membrane transporter NM_080658 -20.66 −0.690 5.44E−04 ACY3 aspartoacylase (aminocyclase) 3 unknown enzyme

186 0.029 BCL2/adenovirus E1B 19kD interacting NM_138278 -21.80 0.851 5.34E−04 0.029 BNIPL protein like Cytoplasm other

NM_152607 -24.18 −1.536 5.37E−04 0.029 D C1orf177 chromosome 1 open reading frame 177 unknown other

NM_005202 -20.88 −0.707 5.30E−04 0.029 COL8A2 collagen, type VIII, alpha 2 Extracellular Space other DnaJ (Hsp40) homolog, subfamily A, NM_001130183 -13.58 0.539 5.25E−04 0.029 DNAJA4 member 4 Nucleus other

NM_181723 -13.95 0.538 5.43E−04 0.029 EFHA2 EF-hand domain family, member A2 unknown other

killer cell lectin-like receptor subfamily C, transmembrane NM_007328 -23.42 1.313 5.25E−04 0.029 D KLRC1 member 1 Plasma Membrane receptor

LOC1001305 NR_028340 -19.97 0.632 5.45E−04 0.029 D 22 hypothetical LOC100130522 unknown other

NM_005797 -20.90 0.692 5.36E−04 0.029 MPZL2 myelin protein zero-like 2 Plasma Membrane other Extracellular NM_004160 -24.42 1.730 5.36E−04 0.029 PYY peptide YY Space other transcription NM_001031680 -22.84 0.965 5.15E−04 0.029 RUNX3 runt-related transcription factor 3 Nucleus regulator

NR_004388 -19.57 0.581 5.34E−04 0.029 SCARNA14 small Cajal body-specific RNA 14 unknown other solute carrier family 28 (sodium-coupled NM_001199633 -25.64 2.523 5.43E−04 0.029 D SLC28A3 nucleoside transporter), member 3 Plasma Membrane transporter solute carrier family 28 (sodium-coupled NM_022127 -25.64 2.523 5.43E−04 0.029 D SLC28A3 nucleoside transporter), member 3 Plasma Membrane transporter solute carrier family 28 (sodium-coupled NR_037638 -25.64 2.523 5.43E−04 0.029 D SLC28A3 nucleoside transporter), member 3 Plasma Membrane transporter

NM_212460 -16.92 0.549 5.58E−04 0.030 ARL4A ADP-ribosylation factor-like 4A Nucleus enzyme

NR_037479 -23.95 1.551 5.63E−04 0.030 mir-3914 unknown microRNA

NM_006601 -14.64 0.539 5.60E−04 0.030 PTGES3 prostaglandin E synthase 3 (cytosolic) Cytoplasm enzyme

NM_001037164 -16.92 0.547 5.77E−04 0.031 ARL4A ADP-ribosylation factor-like 4A Nucleus enzyme

NR_030594 -24.03 −1.528 5.87E−04 0.031 mir-541 microRNA 541 unknown microRNA

187

NM_005952 -18.70 0.562 5.88E−04 0.031 MT1X metallothionein 1X unknown other

NM_032136 -21.76 0.745 5.72E−04 0.031 TKTL2 transketolase-like 2 Cytoplasm enzyme

NM_199242 -20.09 0.609 5.72E−04 0.031 UNC13D unc-13 homolog D (C. elegans) Cytoplasm other wingless-type MMTV integration site family, NM_004625 -18.70 −0.580 5.78E−04 0.031 WNT7A member 7A Extracellular Space cytokine ATP-binding cassette, sub-family C NR_003087 -37.65 24.733 6.10E−04 0.032 D ABCC13 (CFTR/MRP), member 13, pseudogene unknown transporter DEAD/H (Asp-Glu-Ala-Asp/His) box NR_024005 -23.44 −1.083 6.03E−04 0.032 D DDX11L2 polypeptide 11 like 2 unknown other transcription NM_145657 -37.69 24.654 6.10E−04 0.032 GSX1 GS homeobox 1 Nucleus regulator

NR_029635 -25.95 2.718 6.00E−04 0.032 D mir-221 microRNA 221 unknown microRNA

NR_030173 -24.50 1.620 6.06E−04 0.032 mir-432 microRNA 432 unknown microRNA

NM_001190476 -21.59 −0.770 5.95E−04 0.032 MTRNR2L4 MT-RNR2-like 4 unknown other NOP2/Sun domain family, member 5 NR_033322 -21.58 −0.779 5.95E−04 0.032 NSUN5B pseudogene 1 unknown other G-protein coupled NM_003301 -23.04 −1.178 6.09E−04 0.032 TRHR thyrotropin-releasing hormone receptor Plasma Membrane receptor

NM_174881 -24.58 1.704 6.39E−04 0.033 D CRB3 crumbs homolog 3 (Drosophila) Plasma Membrane other DnaJ (Hsp40) homolog, subfamily A, NM_018602 -13.51 0.531 6.28E−04 0.033 DNAJA4 member 4 Nucleus other DnaJ (Hsp40) homolog, subfamily A, NM_001130182 -13.44 0.530 6.37E−04 0.033 DNAJA4 member 4 Nucleus other family with sequence similarity 189, member NM_004816 -17.21 0.544 6.32E−04 0.033 FAM189A2 A2 unknown other

NM_020995 -20.09 −0.658 6.27E−04 0.033 HPR haptoglobin-related protein Extracellular Space peptidase

NM_005562 -21.68 −0.803 6.47E−04 0.033 LAMC2 laminin, gamma 2 Extracellular Space other transcription NM_002315 -22.44 0.919 6.33E−04 0.033 LMO1 LIM domain only 1 (rhombotin 1) Nucleus regulator

NR_031666 -23.54 1.333 6.42E−04 0.033 D mir-548 microRNA 548c unknown microRNA NM_080701 -23.62 1.249 6.42E−04 TREX2 three prime repair exonuclease 2 Nucleus enzyme 188 0.033

NM_001006613 -16.18 0.539 6.42E−04 0.033 WBP5 WW domain binding protein 5 unknown other caspase 6, apoptosis-related cysteine NM_032992 -21.05 0.719 6.77E−04 0.034 CASP6 peptidase Cytoplasm peptidase

NM_004417 -15.57 −0.529 6.70E−04 0.034 DUSP1 dual specificity phosphatase 1 Nucleus phosphatase growth arrest and DNA-damage-inducible, NM_001199741 -17.01 0.543 6.71E−04 0.034 GADD45A alpha Nucleus other

NM_207398 -22.34 −0.891 6.67E−04 0.034 GBP7 guanylate binding protein 7 unknown enzyme interferon induced transmembrane protein 2 NM_006435 -19.44 0.595 6.55E−04 0.034 IFITM2 (1-8D) Plasma Membrane other

NM_000229 -20.02 −0.649 6.57E−04 0.034 LCAT lecithin-cholesterol acyltransferase Extracellular Space enzyme

NR_037432 -25.14 2.302 6.54E−04 0.034 MIR3659 microRNA 3659 unknown microRNA transcription NM_001001890 -18.68 0.562 6.74E−04 0.034 RUNX1 runt-related transcription factor 1 Nucleus regulator Extracellular NM_003710 -22.41 −1.043 6.67E−04 0.034 D SPINT1 serine peptidase inhibitor, Kunitz type 1 Space other Extracellular NM_181642 -22.41 −1.043 6.67E−04 0.034 D SPINT1 serine peptidase inhibitor, Kunitz type 1 Space other

NM_001146197 -20.47 0.740 7.03E−04 0.035 C13orf40 chromosome 13 open reading frame 40 unknown other caspase 1, apoptosis-related cysteine NM_001223 -20.84 0.682 6.96E−04 0.035 CASP1 peptidase (interleukin 1, beta, convertase) Cytoplasm peptidase

NM_001202557 -18.26 0.545 6.97E−04 0.035 CD44 CD44 molecule (Indian blood group) Plasma Membrane other family with sequence similarity 189, member NM_001127608 -17.27 0.540 6.93E−04 0.035 FAM189A2 A2 unknown other low density lipoprotein receptor class A NM_001010978 -27.00 3.775 7.04E−04 0.035 LDLRAD1 domain containing 1 unknown other

NM_032405 -21.64 0.677 7.00E−04 0.035 TMPRSS3 transmembrane protease, serine 3 Plasma Membrane peptidase

NM_030943 -26.39 −3.156 7.41E−04 0.036 AMN amnionless homolog (mouse) Plasma Membrane other

transmembrane NM_001181 -21.63 −0.834 7.17E−04 0.036 ASGR2 asialoglycoprotein receptor 2 Plasma Membrane receptor

NM_001201352 -21.63 −0.834 7.17E−04 0.036 ASGR2 asialoglycoprotein receptor 2 Plasma Membrane transmembrane 189 receptor

NM_032330 -22.27 0.967 7.37E−04 0.036 CAPNS2 calpain, small subunit 2 Cytoplasm other

NM_001267 -20.09 −0.630 7.23E−04 0.036 CHAD chondroadherin Extracellular Space other

NR_024101 -19.37 0.593 7.33E−04 0.036 FLJ35776 hypothetical LOC649446 unknown other growth arrest and DNA-damage-inducible, NM_001199742 -16.98 0.539 7.28E−04 0.036 GADD45A alpha Nucleus other

NM_001005783 -26.35 −3.232 7.41E−04 0.036 D HAO2 hydroxyacid oxidase 2 (long chain) Cytoplasm enzyme matrix metallopeptidase 8 (neutrophil Extracellular NM_002424 -25.32 −2.115 7.21E−04 0.036 MMP8 collagenase) Space peptidase

NM_001142599 -17.14 0.537 7.16E−04 0.036 P4HA2 prolyl 4-hydroxylase, alpha polypeptide II Cytoplasm enzyme

NM_001009994 -20.27 0.636 7.07E−04 0.036 RIPPLY2 ripply2 homolog (zebrafish) Nucleus other transcription NM_004350 -22.83 0.931 7.20E−04 0.036 RUNX3 runt-related transcription factor 3 Nucleus regulator ST6 (alpha-N-acetyl-neuraminyl-2,3-beta- ST6GALNA galactosyl-1,3)-N-acetylgalactosaminide NM_006456 -21.81 −0.847 7.28E−04 0.036 C2 alpha-2,6-sialyltransferase 2 Cytoplasm enzyme

NM_001006614 -16.18 0.534 7.26E−04 0.036 WBP5 WW domain binding protein 5 unknown other

NM_001137608 -20.53 0.721 7.18E−04 0.036 ZNF732 zinc finger protein 732 unknown other

NM_152769 -19.59 −0.603 7.74E−04 0.037 C19orf26 chromosome 19 open reading frame 26 unknown other transcription NM_001755 -16.75 0.533 7.74E−04 0.037 CBFB core-binding factor, beta subunit Nucleus regulator

NM_000088 -21.72 0.740 7.57E−04 0.037 COL1A1 collagen, type I, alpha 1 Extracellular Space other

NM_001184699 -23.41 −1.430 7.53E−04 0.037 D CPXM1 carboxypeptidase X (M14 family), member 1 Extracellular Space peptidase

NM_001083885 -17.61 0.542 7.60E−04 0.037 DFNB31 deafness, autosomal recessive 31 Plasma Membrane other

NM_001081461 -15.32 0.527 7.48E−04 0.037 JMJD6 jumonji domain containing 6 Plasma Membrane other

NM_001029989 -23.75 1.361 7.45E−04 0.037 D KIAA0101 KIAA0101 Nucleus other

NR_027242 -26.25 3.271 7.65E−04 0.037 LOC146336 hypothetical LOC146336 unknown other

190

NR_030375 -22.82 −1.021 7.50E−04 0.037 MIR645 microRNA 645 unknown microRNA phosphatidylethanolamine N- NM_148173 -19.69 −0.604 7.63E−04 0.037 PEMT methyltransferase Cytoplasm enzyme phosphatidylethanolamine N- NM_148172 -19.61 −0.600 7.73E−04 0.037 PEMT methyltransferase Cytoplasm enzyme

NM_001013734 -25.87 2.879 7.65E−04 0.037 RFPL4B ret finger protein-like 4B unknown other SH3 domain binding glutamic acid-rich NM_001001713 -17.29 0.540 7.68E−04 0.037 SH3BGR protein Cytoplasm other

NM_001004320 -21.58 0.756 7.89E−04 0.038 AGMO alkylglycerol monooxygenase Cytoplasm enzyme

NR_027128 -19.70 −0.620 7.82E−04 0.038 C21orf67 chromosome 21 open reading frame 67 Cytoplasm other transcription NM_022845 -16.75 0.532 7.94E−04 0.038 CBFB core-binding factor, beta subunit Nucleus regulator

LOC1001312 NR_026911 -21.97 0.855 8.05E−04 0.038 05 ribosomal protein L21 pseudogene 28 unknown other

NR_034027 -23.25 −1.222 7.90E−04 0.038 LOC338739 hypothetical LOC338739 unknown other aminopeptidase puromycin sensitive NR_036750 -19.29 0.594 8.04E−04 0.038 LOC440434 pseudogene unknown other

NM_000982 -21.97 0.855 8.05E−04 0.038 RPL21 ribosomal protein L21 Cytoplasm other TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, transcription NM_024885 -20.60 0.660 7.85E−04 0.038 TAF7L 50kDa Nucleus regulator

NR_024612 -22.04 −0.834 8.28E−04 0.039 ATXN1L ataxin 1-like unknown other caspase recruitment domain family, member NM_014550 -20.81 −0.657 8.27E−04 0.039 CARD10 10 Cytoplasm other DnaJ (Hsp40) homolog, subfamily B, NM_007034 -14.28 0.522 8.09E−04 0.039 DNAJB4 member 4 Nucleus other

NM_001142473 -23.64 1.314 8.29E−04 0.039 D FAIM3 Fas apoptotic inhibitory molecule 3 unknown other

NM_002006 -15.04 0.523 8.10E−04 0.039 FGF2 fibroblast growth factor 2 (basic) Extracellular Space growth factor G-protein coupled NM_001143828 -23.62 1.187 8.29E−04 0.039 D HRH4 histamine receptor H4 Plasma Membrane receptor NM_001160166 -23.62 1.187 8.29E−04 D HRH4 histamine receptor H4 Plasma Membrane G-protein

191 0.039 coupled receptor

NM_006644 -11.80 0.520 8.11E−04 0.039 HSPH1 heat shock 105kDa/110kDa protein 1 Cytoplasm other

NM_020387 -24.43 1.762 8.22E−04 0.039 RAB25 RAB25, member RAS oncogene family Cytoplasm enzyme transmembrane phosphatase with tensin NM_130785 -23.58 1.081 8.29E−04 0.039 D TPTE/TPTE2 homology Plasma Membrane phosphatase transmembrane phosphatase with tensin NM_199254 -23.58 1.081 8.29E−04 0.039 D TPTE/TPTE2 homology Plasma Membrane phosphatase

NM_016161 -25.48 2.185 8.82E−04 0.040 A4GNT alpha-1,4-N-acetylglucosaminyltransferase Cytoplasm enzyme

NM_001195396 -16.84 0.528 8.74E−04 0.040 ARL4A ADP-ribosylation factor-like 4A Nucleus enzyme

transmembrane NM_080912 -21.62 −0.812 8.62E−04 0.040 ASGR2 asialoglycoprotein receptor 2 Plasma Membrane receptor

NM_207103 -23.25 −1.066 8.78E−04 0.040 C17orf87 chromosome 17 open reading frame 87 unknown other

NM_015404 -17.46 0.535 8.46E−04 0.040 DFNB31 deafness, autosomal recessive 31 Plasma Membrane other

NM_001173425 -17.46 0.534 8.63E−04 0.040 DFNB31 deafness, autosomal recessive 31 Plasma Membrane other transcription NM_138281 -23.45 1.164 8.90E−04 0.040 D DLX4 distal-less homeobox 4 Nucleus regulator forkhead-associated (FHA) phosphopeptide NM_052929 -19.27 −0.569 8.58E−04 0.040 FHAD1 binding domain 1 unknown other growth factor independent 1B transcription NM_001135031 -37.79 −24.456 8.59E−04 0.040 D GFI1B transcription repressor Nucleus regulator growth factor independent 1B transcription NM_004188 -37.79 −24.456 8.59E−04 0.040 D GFI1B transcription repressor Nucleus regulator G-protein coupled NM_032787 -20.95 −0.663 8.81E−04 0.040 GPR128 G protein-coupled receptor 128 Plasma Membrane receptor

NM_175857 -37.73 −24.573 8.59E−04 0.040 KRTAP8-1 keratin associated protein 8-1 unknown other

NM_001001676 -37.79 −24.459 8.59E−04 0.040 LCN9 lipocalin 9 Extracellular Space transporter

LOC1005060 NR_037878 -24.61 1.911 8.81E−04 0.040 85 hypothetical LOC100506085 unknown other NR_029701 -37.79 8.59E−04 D mir-146 microRNA 146b unknown microRNA

192 −24.446 0.040

NR_031610 -37.68 −24.680 8.59E−04 0.040 MIR1205 microRNA 1205 unknown microRNA NTPase, KAP family P-loop domain NM_198478 -21.89 −0.809 8.50E−04 0.040 NKPD1 containing 1 unknown other

NM_000917 -16.04 0.526 8.54E−04 0.040 P4HA1 prolyl 4-hydroxylase, alpha polypeptide I Cytoplasm enzyme

NM_001142596 -16.06 0.525 8.61E−04 0.040 P4HA1 prolyl 4-hydroxylase, alpha polypeptide I Cytoplasm enzyme

NM_017817 -20.79 0.637 8.83E−04 0.040 RAB20 RAB20, member RAS oncogene family Cytoplasm enzyme transcription NM_006867 -19.17 0.564 8.78E−04 0.040 RBPMS RNA binding protein with multiple splicing unknown regulator

SLC22A18A solute carrier family 22 (organic cation NM_007105 -21.19 −0.667 8.52E−04 0.040 S transporter), member 18 antisense unknown other

NM_181727 -37.85 −24.327 8.59E−04 0.040 SPATA12 spermatogenesis associated 12 unknown other

NM_024660 -21.89 0.770 8.71E−04 0.040 TMEM149 transmembrane protein 149 unknown other

NR_028357 -37.86 −24.309 8.59E−04 0.040 D TMEM30C transmembrane protein 30C unknown other transcription NM_182975 -18.29 0.541 8.47E−04 0.040 ZNF326 zinc finger protein 326 Nucleus regulator

NM_001080456 -24.52 1.825 8.81E−04 0.040 ZSCAN5B zinc finger and SCAN domain containing 5B unknown other

NM_005738 -16.83 0.527 9.00E−04 0.041 ARL4A ADP-ribosylation factor-like 4A Nucleus enzyme

transmembrane NM_080913 -21.64 −0.820 9.21E−04 0.041 ASGR2 asialoglycoprotein receptor 2 Plasma Membrane receptor caspase 1, apoptosis-related cysteine NM_033293 -20.91 0.659 9.14E−04 0.041 CASP1 peptidase (interleukin 1, beta, convertase) Cytoplasm peptidase

NM_001156474 -20.35 0.638 9.16E−04 0.041 CCDC81 coiled-coil domain containing 81 unknown other cell division cycle 45 homolog (S. NM_001178010 -24.78 −1.983 9.03E−04 0.041 D CDC45 cerevisiae) Nucleus other cell division cycle 45 homolog (S. NM_003504 -24.78 −1.983 9.03E−04 0.041 D CDC45 cerevisiae) Nucleus other

NM_001178134 -18.91 −0.548 9.02E−04 0.041 CXCL12 chemokine (C-X-C motif) ligand 12 Extracellular Space cytokine

193 growth arrest and DNA-damage-inducible, NM_001924 -16.96 0.529 9.15E−04 0.041 GADD45A alpha Nucleus other

NM_016527 -27.03 −3.873 9.21E−04 0.041 D HAO2 hydroxyacid oxidase 2 (long chain) Cytoplasm enzyme

LOC1001446 NR_021493 -22.02 0.870 9.33E−04 0.041 04 hypothetical LOC100144604 unknown other

NR_026972 -20.46 0.655 9.30E−04 0.041 LOC285830 hypothetical LOC285830 unknown other

NR_024014 -21.05 0.667 9.29E−04 0.041 PP14571 similar to hCG1777210 unknown other

TBC1D26/T NM_001039397 -27.03 −3.875 9.21E−04 0.041 D BC1D28 TBC1 domain family, member 26 unknown other transcription factor 15 (basic helix-loop- transcription NM_004609 -22.78 0.912 9.05E−04 0.041 TCF15 helix) Nucleus regulator

transmembrane NM_080914 -21.70 −0.801 9.49E−04 0.042 ASGR2 asialoglycoprotein receptor 2 Plasma Membrane receptor

NR_037487 -25.39 2.364 9.54E−04 0.042 MIR3922 microRNA 3922 unknown microRNA

NR_036178 -24.88 2.007 9.58E−04 0.042 MIR4296 microRNA 4296 unknown microRNA

NM_025239 -22.39 −0.915 9.51E−04 0.042 PDCD1LG2 programmed cell death 1 ligand 2 Plasma Membrane other

NM_199346 -22.49 −0.937 9.52E−04 0.042 PFN4 profilin family, member 4 unknown other solute carrier family 10 (sodium/bile acid NM_001010893 -19.91 0.605 9.61E−04 0.042 SLC10A5 cotransporter family), member 5 unknown other

NM_001032367 -22.42 −1.014 9.50E−04 0.042 D SPINT1 serine peptidase inhibitor, Kunitz type 1 Extracellular Space other

NM_024022 -20.92 0.641 9.42E−04 0.042 TMPRSS3 transmembrane protease, serine 3 Plasma Membrane peptidase

C7orf28B/CC CCZ1 vacuolar protein trafficking and NM_198097 -22.34 0.892 9.98E−04 0.043 Z1 biogenesis associated homolog (S. cerevisiae) unknown other caspase 1, apoptosis-related cysteine NM_033292 -20.83 0.660 1.00E−03 0.043 CASP1 peptidase (interleukin 1, beta, convertase) Cytoplasm peptidase cytochrome P450, family 19, subfamily A, NM_000103 -24.87 2.040 9.85E−04 0.043 D CYP19A1 polypeptide 1 Cytoplasm enzyme cytochrome P450, family 19, subfamily A, NM_031226 -24.87 2.040 9.85E−04 0.043 D CYP19A1 polypeptide 1 Cytoplasm enzyme

194 DnaJ (Hsp40) homolog, subfamily C, NM_033105 -24.41 −1.476 1.00E−03 0.043 DNAJC5B member 5 beta unknown transporter

NM_058248 -22.78 0.948 9.94E−04 0.043 D DNASE2B deoxyribonuclease II beta Cytoplasm enzyme

NM_001081492 -23.10 −1.048 9.79E−04 0.043 D KRT80 keratin 80 unknown other

NM_182507 -23.10 −1.048 9.79E−04 0.043 D KRT80 keratin 80 unknown other ligand- dependent nuclear receptor subfamily 4, group A, nuclear NM_001202233 -16.47 −0.518 9.75E−04 0.043 NR4A1 member 1 Nucleus receptor

NM_138454 -24.89 −2.110 9.96E−04 0.043 NXNL1 nucleoredoxin-like 1 Cytoplasm enzyme

NM_001017962 -16.04 0.518 1.00E−03 0.043 P4HA1 prolyl 4-hydroxylase, alpha polypeptide I Cytoplasm enzyme

NM_001142595 -16.04 0.518 1.00E−03 0.043 P4HA1 prolyl 4-hydroxylase, alpha polypeptide I Cytoplasm enzyme

NM_024787 -20.21 0.618 9.98E−04 0.043 RNF122 ring finger protein 122 unknown other

NR_000005 -17.00 0.520 9.80E−04 0.043 SNORD15A small nucleolar RNA, C/D box 15A unknown other

NM_052957 -17.51 0.531 1.04E−03 0.044 ACRC acidic repeat containing unknown other

NM_006417 -17.70 −0.524 1.04E−03 0.044 IFI44 interferon-induced protein 44 Cytoplasm other

NR_024541 -26.41 2.958 1.03E−03 0.044 D LY6G6E lymphocyte antigen 6 complex, locus G6E unknown other

NR_029709 -26.29 3.206 1.03E−03 0.044 mir-190 microRNA 190 unknown microRNA

NR_029966 -23.53 1.147 1.02E−03 0.044 mir-433 microRNA 433 unknown microRNA

NM_001085354 -17.25 0.525 1.02E−03 0.044 MORC4 MORC family CW-type zinc finger 4 unknown other

NM_152672 -26.41 2.965 1.03E−03 0.044 OSTalpha organic solute transporter alpha Plasma Membrane transporter Extracellular NM_002429 -24.87 −1.842 1.05E−03 0.045 MMP19 matrix metallopeptidase 19 Space peptidase serine peptidase inhibitor, Kazal type 8 NM_001080525 -24.93 −1.698 1.05E−03 0.045 SPINK8 (putative) unknown other sepiapterin reductase (7,8- NM_003124 -18.25 0.534 1.04E−03 0.045 SPR dihydrobiopterin:NADP+ oxidoreductase) Cytoplasm enzyme

195 G-protein coupled NM_000634 -22.82 0.951 1.09E−03 0.046 CXCR1 chemokine (C-X-C motif) receptor 1 Plasma Membrane receptor Extracellular NM_001134941 -24.45 −1.608 1.10E−03 0.046 D GHRL ghrelin/obestatin prepropeptide Space growth factor

NM_178439 -17.20 0.523 1.07E−03 0.046 GMCL1 germ cell-less homolog 1 (Drosophila) Nucleus other testicular cell adhesion molecule 1 homolog NR_002947 -22.43 0.756 1.08E−03 0.046 TCAM1 (mouse), pseudogene Extracellular Space other

NM_000547 -25.05 −2.184 1.09E−03 0.046 D TPO thyroid peroxidase Plasma Membrane enzyme

NM_175719 -25.05 −2.184 1.09E−03 0.046 D TPO thyroid peroxidase Plasma Membrane enzyme

NM_175721 -25.05 −2.184 1.09E−03 0.046 D TPO thyroid peroxidase Plasma Membrane enzyme

NM_175722 -25.05 −2.184 1.09E−03 0.046 D TPO thyroid peroxidase Plasma Membrane enzyme

NM_152589 -25.43 −1.913 1.11E−03 0.047 C12orf50 chromosome 12 open reading frame 50 unknown other

NM_001007271 -25.09 −2.133 1.12E−03 0.047 D DUSP13 dual specificity phosphatase 13 Cytoplasm phosphatase

NM_000189 -19.04 0.545 1.12E−03 0.047 HK2 hexokinase 2 Cytoplasm kinase

NM_153337 -25.55 −2.796 1.13E−03 0.047 D SNX20 sorting nexin 20 unknown other

NM_001142598 -17.16 0.515 1.15E−03 0.048 P4HA2 prolyl 4-hydroxylase, alpha polypeptide II Cytoplasm enzyme

NM_033068 -37.75 24.527 1.18E−03 0.049 ACPT acid phosphatase, testicular unknown phosphatase AT rich interactive domain 3C (BRIGHT- NM_001017363 -23.72 −1.312 1.17E−03 0.049 ARID3C like) unknown other

NM_178519 -24.11 1.537 1.17E−03 0.049 C17orf55 chromosome 17 open reading frame 55 unknown other Extracellular NM_001030047 -37.89 24.256 1.18E−03 0.049 D KLK3 kallikrein-related peptidase 3 Space peptidase

NR_030336 -37.70 24.623 1.18E−03 0.049 mir-605 microRNA 605 unknown microRNA Extracellular NM_021920 -37.70 24.637 1.18E−03 0.049 SCT secretin Space other solute carrier family 6 (neurotransmitter NM_001044 -37.75 24.530 1.18E−03 0.049 SLC6A3 transporter, dopamine), member 3 Plasma Membrane transporter NR_003194 -21.82 −0.700 1.19E−03 SNORD114- small nucleolar RNA, C/D box 114-2 unknown other 196 0.049 2 testis-specific transcript, Y-linked 16 (non- NR_001552 -37.82 24.401 1.18E−03 0.049 TTTY16 protein coding) unknown other

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"#&!(#"')$$ - "")(-2 #&&'$#"'(#( (#" "(&#&#("# #- "#&!(#"") #(

&&""((#"")!&2 ##""(&(#"'( ##(*&)""#('%)"&'(+"#"(&# '

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&#) -" ##)'(#!) ($ #!$&'#"#&&($3* )2)$ ("(!) ($ ! (&"'&$('+##&

'" "+'(''("& '-!# ") ""!&$&'"("(",(# )!"'2 #(#"'( "")(-

 ) ( #(#"#&($&#("#-("+(('(-$2# &#+'"((::>#&"')'"( "")(-

(+-" -''(#'"(+#& '2

197 Supplementary Table 6.3: Next Generation Sequencing identified microglial markers

Log Log Gene Gene ID Conc FC p-value Symbol Gene Name Reference

NM_000201 -19.18 0.757 9.28E-06 ICAM1 intercellular adhesion molecule 1 (Chang et al., 2006)

NM_002965 -18.97 0.635 1.33E-04 S100A9 S100 calcium binding protein A9 (Tambuyzer and Nouwen, 2005)

NM_203416 -18.17 0.605 1.34E-04 CD163 CD163 molecule (Roberts et al., 2004)

NM_001005377 -20.77 0.577 3.29E-03 PLAUR plasminogen activator, urokinase receptor (Walker et al., 2002)

NM_000610 -16.37 0.574 2.57E-04 CD44 CD44 molecule (Indian blood group) (Havenith et al., 1998) Fc fragment of IgG, low affinity IIIa, receptor

NM_000569 -19.79 0.399 1.64E-02 FCGR3A (Ulvestad et al., 1994) (CD16a) peroxisome proliferator-activated receptor

NM_138712 -18.29 0.365 2.48E-02 PPARG (Bernardo et al., 2000) gamma

NM_001040021 -19.03 0.33 3.76E-02 CD14 CD14 molecule (Guillemin et al., 1997) -

NM_001199834 -18.97 8.06E-05 VCAM1 vascular cell adhesion molecule 1 (Peterson et al., 2002) 0.674 -

NM_005562 -21.68 6.47E-04 LAMC2 laminin, gamma 2 (Guillemin et al., 1997) 0.803

&# !& &'"("( ('& -,$&''"'""( -&"( -&) ((+"'.#$&"

"#"(&# '2 ##""(&(#"'( ##(*&)""#('%)"&'(+"#"(&# '""*) '

+('.#$&"2 #'( ## "#"*) (&"'&$('& (*(##"(&# '6$#'(** )'5"&'"

'.#$&"7/+(($3* )"(&') (#(+#3'(3('(2&$&'"('( ''#*&-&(%3* )/&#) -

" ##)'(#!) ($ #!$&'#"#&&($3* )2

198

Supplementary Table 6.4: Clinical demographic correlations with experimental measures

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