Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Maculitis

Total Page:16

File Type:pdf, Size:1020Kb

Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Maculitis Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Maculitis Chemical Activity Count (+)-ALPHA-VINIFERIN 2 (+)-CATECHIN 6 (+)-CORYDALINE 1 (+)-EUDESMA-4(14),7(11)-DIENE-3-ONE 1 (+)-GALLOCATECHIN 1 (+)-GLAUCINE 1 (+)-HERNANDEZINE 1 (+)-PSEUDOEPHEDRINE 1 (+)-SYRINGARESINOL 2 (-)-16,17-DIHYDROXY-16BETA-KAURAN-19-OIC 1 (-)-ALPHA-BISABOLOL 1 (-)-ALPHA-HYDRASTINE 1 (-)-BETONICINE 2 (-)-BISPARTHENOLIDINE 1 (-)-BORNYL-CAFFEATE 2 (-)-BORNYL-FERULATE 2 (-)-BORNYL-P-COUMARATE 2 (-)-DANSHEXINKUN 1 (-)-EPIAFZELECHIN 1 (-)-EPICATECHIN 2 (-)-EPICATECHIN-3-O-GALLATE 1 (-)-EPIGALLOCATECHIN 3 (-)-EPIGALLOCATECHIN-3-GALLATE 1 (-)-EPIGALLOCATECHIN-3-O-GALLATE 2 (-)-EPIGALLOCATECHIN-GALLATE 5 (-)-HYDROXYJASMONIC-ACID 2 (-)-STYLOPINE 1 Chemical Activity Count (-)-TETRAHYDROCOLUMBAMINE 1 (1'S)-1'-ACETOXYCHAVICOL-ACETATE 2 (15:1)-CARDANOL 1 (2R)-(12Z,15Z)-2-HYDROXY-4-OXOHENEICOSA-12,15-DIEN-1-YL-ACETATE 1 (7R,10R)-CAROTA-1,4-DIENALDEHYDE 1 (E)-4-(3',4'-DIMETHOXYPHENYL)-BUT-3-EN-OL 1 1,2,3,6-TETRA-O-GALLYOL-BETA-D-GLUCOSE 1 1,2,6-TRI-O-GALLOYL-BETA-D-GLUCOSE 1 1,3,6-TRIHYDROXY-2,7-DIMETHOXY-XANTHONE 1 1,6,7-TRIHYDROXY-2,3-DIMETHOXY-XANTHONE 1 1,7-BIS(3,4-DIHYDROXYPHENYL)HEPTA-4E,6E-DIEN-3-ONE 2 1,7-BIS-(4-HYDROXYPHENYL)-1,4,6-HEPTATRIEN-3-ONE 1 1,8-CINEOLE 1 1-HYDROXY-3,6,7-TRIMETHOXY-XANTHONE 1 1-METHOXY-2,3-METHYLENEDIOXY-XANTHONE 1 1-O-(2,3,4-TRIHYDROXY-3-METHYL)-BUTYL-6-O-FERULOYL-BETA-D-GLUCOPYRANOSIDE 2 10-ACETOXY-8-HYDROXY-9-ISOBUTYLOXY-6-METHOXYTHYMOL 1 10-DEHYDROGINGERDIONE 1 10-GINGERDIONE 1 13',II8-BIAPIGENIN 2 13-OXYINGENOL-ESTER 1 16,17-DIHYDROXY-16BETA-KAURAN-19-OIC 1 16-HYDROXYINGENOL-ESTER 1 2'-O-GLYCOSYLVITEXIN 1 2'O-ACETYLACETOSIDE 1 2,3,7-TRIHYDROXY-5-(3,4-DIHYDROXY-E-STYRYL)-6,7,8,9-TETRAHYDRO-5H- 2 BENZOCYCLOHEPTENE 2-(3',4-DIPHENYL)-ETHANOL 1 2 Chemical Activity Count 2-BETA,3BETA-27-TRIHYDROXYOLEAN-12-ENE-23,28-DICARBOXYLIC-ACID 1 2-CAFFEOYL-OXY-3-{2-(4-HYDROXYBENZYL)-4,5-DIHYDROXY}PHENYLPROPIONIC-ACID 1 2-METHYL-5-(PENTADEC-CIS-8-ENYL)-RESORCINOL 1 2-METHYL-5-(PENTADECA-CIS-8-CIS-11-DIENYL)-RESORCINOL 1 2-PHENYL-ETHYL-O-BETA-D-XYLOPYRANOSYL-(1,6)-BETA-D-GLUCOSIDE 1 20-DEOXYINGENOL-ESTER 1 22BETA-ESCIN 1 24-METHYLENE-CYCLOARTANOL 1 28-HYDROXY-FRIEDELANE-1,3-DIONE 1 3',4',5,6,7-PENTAACETOXY-8-METHOXY-FLAVONE 1 3',4',5,7-TETRAHYDROXYFLAVONE 1 3',4',6-TRIHYDROXY-5,7,8-TRIMETHOXY-FLAVONE 1 3,3',4-TRI-O-METHYL-ELLAGIC-ACID 1 3,3'-DIINDOLYMETHANE 1 3,3'-DIMETHYLELLAGIC-ACID 1 3,4,5-TRI-O-CAFFEOYLQUINIC-ACID 1 3,4-DICAFFEOYL-QUINIC-ACID 1 3,4-DIHYDROXYBENZOATE 1 3,4-DIMETHOXYCINNAMIC-ACID 1 3,4-HYDROXYCINNAMIC-ACID 2 3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER 2 3,4-SECOTRITERPENE-ACID-20-EPI-KOETJAPIC-ACID 1 3,5,8,3',4'-PENTAHYDROXYFLAVONE 1 3,5-DI-O-CAFFEOYLQUINIC-ACID 1 3,5-DICAFFEOYL-QUINIC-ACID 2 3,7,8,2',5'-PENTAHYDROXYFLAVONE 1 3-(PENTADECA-CIS-8-CIS-11,14-TRIENYL)-PHENOL 1 3 Chemical Activity Count 3-(PENTADECA-CIS-8-CIS-12-DIENYL)-PHENOL 1 3-ACETYL-3',4'-DIHYDROXY-5,6,7-TRIMETHOXY-FLAVONE 1 3-ACETYLACONITINE 1 3-BETA-23,28-TRIHYDROXY-12-OLEANENE-23-CAFFEATE 1 3-BETA-23,28-TRIHYDROXY-12-OLEANENE-3-BETA-CAFFEATE 1 3-BETA-HYDROXY-2,3-DIHYDROWITHANOLIDE-F 1 3-BETA-TRANS-(3,4-DIHYDROXYCINNAMOYLOXY)-20(29)-LUPEN-28-OIC-ACID 1 3-BETA-TRANS-(3,4-DIHYDROXYCINNAMOYLOXY)-OLEAN-12-EN-28-OIC-ACID 1 3-BETA-TRANS-(3,4-DIHYDROXYCINNAMOYLOXY)-OLEAN-18-EN-28-OIC-ACID 1 3-HYDROXY-6-METHOXY-COUMARIN 1 3-HYDROXY-COUMARIN 1 3-HYDROXY-FLAVONE 3 3-N-BUTYL-PHTHALIDE 1 3-O-ACETYLOLEANOLIC-ACID 1 3-O-CAFFEOYLQUINIC-ACID 1 3-OXO-11-ALPHA-HYDROXYOLEAN-12-ENE-30-OIC-ACID 1 3-OXO-11-ALPHA-METHOXYOLEAN-12-ENE-30-OIC-ACID 1 3-OXO-OLEAN-9(11),12-DIENE-30-OIC-ACID 1 4',5,6,7-TETRAHYDROXY-3',8-DIMETHOXY-FLAVONE 1 4',5,7-TRIHYDROXY-6,8-DIMETHOXY-FLAVONE 1 4',6-DIHYDROXY-3',5,7,8-TETRAMETHOXY-FLAVONE 1 4',6-DIHYDROXY-5,7,8-TRIMETHOXY-FLAVONE 1 4'-HYDROXY-3',5,6,7,8-PENTAMETHOXY-FLAVONE 1 4'-HYDROXY-5,6,7,8-TETRAMETHOXY-FLAVONE 1 4,5-DI-O-CAFFEOYLQUINIC-ACID 1 4-(ALPHA-RHAMNOPYRANOSYL)ELLAGIC-ACID 1 4-ACETYLARABINOSYL-ELLAGIC-ACID 1 4 Chemical Activity Count 4-ACETYLXYLOSYL-ELLAGIC-ACID 1 4-ALLYL-PYROCATECHOL 1 4-AMINO-4-CARBOXYCHROMAN-2-ONE 1 4-ARABINOSYL-ELLAGIC-ACID 1 4-HYDROXY-6,7-METHYLENEDIOXY-COUMARIN 1 4-HYDROXY-TRITRIACONTANE-16,18-DIONE 1 4-HYDROXYCOUMARIN 1 4-KETOPINORESINOL 2 4-METHOXYCOUMARIN 1 4-O-CAFFEOYLQUINIC-ACID 1 4-O-METHYLELLAGIC-ACID 1 4-TERPINEOL 2 4-VINYL-GUAIACOL 1 5,6,7-TRIHYDROXY-8-METHOXY-FLAVONE 1 5,6-DIHYDROXY-7,8-DIMETHOXY-FLAVONE 1 5,7-DIHYDROXYCOUMARIN-7-METHYL-ETHER 1 5,7-DIMETHOXYCOUMARIN 1 5,7-DIMETHOXYFLAVONE 1 5,8-DIHYDROXYBENZOPYRANONE 2 5-(PENTADEC-CIS-8-ENYL)-RESORCINOL 1 5-(PENTADECA-CIS-8-CIS-11,14-TRIENYL)-RESORCINOL 1 5-(PENTADECA-CIS-8-CIS-11-DIENYL)-RESORCINOL 1 5-DEOXYINGENOL-ESTER 1 5-HYDROXY-8-O-BETA-D-GLUCOPYRANOSYL-BENZOPYRANONE 2 5-O-BETA-D-GLUCOPYRANOSYL-3-1-(4-PHENYL)-DECANE 1 5-O-CAFFEOYLQUINIC-ACID 1 5-PENTADECYL-RESORCINOL 1 5 Chemical Activity Count 6'-O-ACETYL-DAIDZIN 1 6'-O-ACETYL-GENISTIN 1 6,3'4'-TRIHYDROXY-5,7,8-TRIMETHOXYFLAVONE 1 6,7,4'-TRIHYDROXYISOFLAVAN 1 6,7,4'-TRIHYDROXYISOFLAVANONE 1 6,7,4'-TRIHYDROXYISOFLAVONE 1 6,7-DI-4'-METHOXYISOFLAVAN 1 6,7-DI-4'-METHOXYISOFLAVANONE 1 6,7-DI-4'-METHOXYISOFLAVONE 1 6,7-DIACETOXYCOUMARIN 1 6,7-DIHYDROXY-4'-METHOXYISOFLAVAN 1 6,7-DIHYDROXY-4'-METHOXYISOFLAVANONE 1 6,7-DIHYDROXY-4'-METHOXYISOFLAVONE 1 6,7-DIHYDROXYCOUMARIN 1 6,7-DIMETHYLAESCULETIN 1 6,7-DIMETHYLESCULETIN 1 6,8-DI-(GAMMA-GAMMA-DIMETHYL-ALLYL)-GENISTEIN 1 6-(PENTADEC-CIS-8-ENYL)-SALICYLIC-ACID 1 6-(PENTADECA-CIS-8-CIS-11,14-TRIENYL)-SALICYLIC-ACID 1 6-(PENTADECYL)-SALICYLIC-ACID 1 6-(PENTADECYL-CIS-8-CIS-11-DIENYL)-SALICYLIC-ACID 1 6-DEHYDROGINGERDIONE 1 6-DEOXYJACAREUBIN 1 6-GINGERDIOL 1 6-GINGERDIONE 1 6-GINGEROL 2 6-HYDROXY-5,7,8-TRIMETHOXY-FLAVONE 1 6 Chemical Activity Count 6-HYDROXY-LUTEOLIN 1 6-HYDROXYKAEMPFEROL-3,6-DIMETHYL-ETHER 1 6-O-(2''-ACETYL-3'',4''-O-DI-P-METHOXYCINNAMOYL-ALPHA-L-RHAMNOPYRANOSYL)-CATALPOL 1 6-O-(4''-ACETYL-2'',3''-O-DI-P-METHOXYCINNAMOYL-ALPHA-L-RHAMNOPYRANOSYL)-CATALPOL 1 6-O-TRANS-FERULOYL-AJUGOL 1 6-SHOGAOL 1 7,8-DIHYDROXYFLAVONE 1 7-ACETOXY-6-METHOXYCOUMARIN 1 7-METHOXYCOUMARIN 1 7-METHYL-AXILLARIN 1 7-METHYLCAPILLARISIN 1 7-N-BUTOXY-3,2',5'-TRIHYDROXYFLAVONE 1 7-O-ACETYL-8-EPI-LOGANIC-ACID 1 7-[3-(3,4-DIHYDROXY-4-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YLOXY)-4,5-DIHYDROXY-6- 1 HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLOXY]...
Recommended publications
  • Cornus Canadensis Serge Lavoie, Isabelle Côté, André Pichette, Charles Gauthier, Michaël Ouellet, Francine Nagau-Lavoie, Vakhtang Mshvildadze, Jean Legault
    Chemical composition and anti-herpes simplex virus type 1 (HSV-1) activity of extracts from Cornus canadensis Serge Lavoie, Isabelle Côté, André Pichette, Charles Gauthier, Michaël Ouellet, Francine Nagau-Lavoie, Vakhtang Mshvildadze, Jean Legault To cite this version: Serge Lavoie, Isabelle Côté, André Pichette, Charles Gauthier, Michaël Ouellet, et al.. Chem- ical composition and anti-herpes simplex virus type 1 (HSV-1) activity of extracts from Cornus canadensis. BMC Complementary and Alternative Medicine, BioMed Central, 2017, 17 (1), pp.123. 10.1186/s12906-017-1618-2. pasteur-01534565 HAL Id: pasteur-01534565 https://hal-riip.archives-ouvertes.fr/pasteur-01534565 Submitted on 7 Jun 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution - NonCommercial - ShareAlike| 4.0 International License Lavoie et al. BMC Complementary and Alternative Medicine (2017) 17:123 DOI 10.1186/s12906-017-1618-2 RESEARCH ARTICLE Open Access Chemical composition and anti-herpes simplex virus type 1 (HSV-1) activity of extracts from Cornus canadensis Serge Lavoie1, Isabelle Côté1, André Pichette1, Charles Gauthier1,2, Michaël Ouellet1, Francine Nagau-Lavoie1, Vakhtang Mshvildadze1 and Jean Legault1* Abstract Background: Many plants of boreal forest of Quebec have been used by Native Americans to treat a variety of microbial infections.
    [Show full text]
  • Infraspecific Variability in the Flavonoid Composition of Artemisia Vulgaris L
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE Acta Bot. Croat. 65 (1), 13–18, 2006 CODEN: ABCRA25 ISSN 0365–0588 Infraspecific variability in the flavonoid composition of Artemisia vulgaris L. MILENA NIKOLOVA* Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev str. 1113 Sofia, Bulgaria Surface flavonoid profiles in forty populations of Artemisia vulgaris L. (Asteraceae) were analyzed. The major constituents observed in the leaf exudates were methylated flavonoid aglycones based mainly on quercetin. Three infraspecific flavonoid chemotypes were de- termined, the chrysosplenetin (quercetagetin 3,6,7,3’-tetramethyl ether) chemotype, the artemetin (quercetagetin 3,6,7,3’,4’-pentamethyl ether) chemotype and chemotype with- out these two compounds. Most of the populations corresponded to these chemotypes. Key words: Artemisia vulgaris, Asteraceae, flavonoid aglycones, chrysosplenetin, arte- metin, chemotype Introduction Surface flavonoid aglycones are often used in chemotaxonomic studies on Asteraceae at the generic and species level (VALANT-VETSCHERA and WOLLENWEBER 1996, WOLLEN- WEBER et al. 1997, STEVENS et al. 1999). Recent articles showed that a flavonoid pattern couldalsobespecificforachemotype(REP^ÁK et al. 1999, WILLIAMS et al. 2000, MARTONFI et al. 2001, VIEIRA et al. 2003). The species of the genus Artemisia (Asreraceae) have been extensively surveyed for their surface flavonoid constituents (WOLLENWEBER et al. 1989, VALANT-VETSCHERA and WOLLENWEBER 1995, WOLLENWEBER and VALANT-VETSCHERA 1996). Artemisia vulgaris L (Asteraceae) is a perennial polymorphic species, widespread in temperate areas (South Europe, North Africa, North America and Asia). Simple flavonol methyl ethers have been reported for West-European populations (VALANT-VETSCHERA et al.
    [Show full text]
  • Phytochemical Analysis and Antimicrobial Activity of Myrcia Tomentosa (Aubl.) DC
    molecules Article Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves Fabyola Amaral da Silva Sa 1,3, Joelma Abadia Marciano de Paula 2, Pierre Alexandre dos Santos 3, Leandra de Almeida Ribeiro Oliveira 3, Gerlon de Almeida Ribeiro Oliveira 4, Luciano Morais Liao 4 , Jose Realino de Paula 3,* and Maria do Rosario Rodrigues Silva 1,* 1 Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia 74605-050, Brazil; [email protected] 2 Unit of Exact and Technologic Sciences, Goias State University, Anápolis 75132-400, Brazil; [email protected] 3 Faculty of Pharmacy, Federal University of Goias, Goiânia 74605-170, Brazil; [email protected] (P.A.d.S.); [email protected] (L.d.A.R.O.) 4 Chemistry Institute, Federal University of Goiás, Goiânia 74690-900, Brazil; [email protected] (G.d.A.R.O.); [email protected] (L.M.L.) * Correspondence: [email protected] (J.R.d.P.); [email protected] (M.d.R.R.S.); Tel.: +55-62-3209-6127 (M.d.R.R.S.); Fax: +55-62-3209-6363 (M.d.R.R.S.) Academic Editor: Isabel C. F. R. Ferreira Received: 23 May 2017; Accepted: 29 June 2017; Published: 4 July 2017 Abstract: This work describes the isolation and structural elucidation of compounds from the leaves of Myrcia tomentosa (Aubl.) DC. (goiaba-brava) and evaluates the antimicrobial activity of the crude extract, fractions and isolated compounds against bacteria and fungi. Column chromatography was used to fractionate and purify the extract of the M. tomentosa leaves and the chemical structures of the compounds were determined using spectroscopic techniques.
    [Show full text]
  • ISOLATION, CHARACTERISATION AND/OR EVALUATION of PLANT EXTRACTS for ANTICANCER POTENTIAL KARUPPIAH PILLAI MANOHARAN (M.Sc., M.Ph
    ISOLATION, CHARACTERISATION AND/OR EVALUATION OF PLANT EXTRACTS FOR ANTICANCER POTENTIAL KARUPPIAH PILLAI MANOHARAN (M.Sc., M.Phil., B.Ed.,) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMISTRY NATIONAL UNIVERSITY OF SINGAPORE 2006 Acknowledgements I wish to express my sincere gratitude and appreciation to my supervisors, Associate Prof. Yang Dai Wen and Associate Prof. Tan, Benny Kwong Huat for their advice, suggestions, constructive criticisms, critical comments and constant guidance throughout the course my study. I am very thankful to Asst. Prof. Henry, Mok Yu-Keung; his supervisor-like role throughout my research work is greatly appreciated. I am very grateful to Prof. Sim Keng Yeow for his help, support and guidance at the beginning of this course of study. I would like to thank all the technical staffs of Departments of Chemistry and Pharmacology for their superb technical assistance. My sincere thanks are due to Ms. Annie Hsu for her technical assistance at the traditional medicine and natural product research laboratory, Department of Pharmacology, Faculty of Medicine. I would like to thank Dr. Fan Sing Jong, NMR Manager for his help in the structure elucidation. I would like to thank Associate Prof. Hugh Tan Tiang Wah and Chua Keng Soon, Senior Laboratory Officer (RMBR), Herbarium, for the identification of plant materials, Eugenia grandis and Fagraea fragrans. I am very grateful to the former head Prof. Lee Hian Kee and the present head Prof. Hor Tzi Sum, Andy, Department of Chemistry for facilitating requests and approvals during the period of my study. My appreciation also goes to all my friends.
    [Show full text]
  • Fighting Bisphenol A-Induced Male Infertility: the Power of Antioxidants
    antioxidants Review Fighting Bisphenol A-Induced Male Infertility: The Power of Antioxidants Joana Santiago 1 , Joana V. Silva 1,2,3 , Manuel A. S. Santos 1 and Margarida Fardilha 1,* 1 Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal; [email protected] (J.S.); [email protected] (J.V.S.); [email protected] (M.A.S.S.) 2 Institute for Innovation and Health Research (I3S), University of Porto, 4200-135 Porto, Portugal 3 Unit for Multidisciplinary Research in Biomedicine, Institute of Biomedical Sciences Abel Salazar, University of Porto, 4050-313 Porto, Portugal * Correspondence: [email protected]; Tel.: +351-234-247-240 Abstract: Bisphenol A (BPA), a well-known endocrine disruptor present in epoxy resins and poly- carbonate plastics, negatively disturbs the male reproductive system affecting male fertility. In vivo studies showed that BPA exposure has deleterious effects on spermatogenesis by disturbing the hypothalamic–pituitary–gonadal axis and inducing oxidative stress in testis. This compound seems to disrupt hormone signalling even at low concentrations, modifying the levels of inhibin B, oestra- diol, and testosterone. The adverse effects on seminal parameters are mainly supported by studies based on urinary BPA concentration, showing a negative association between BPA levels and sperm concentration, motility, and sperm DNA damage. Recent studies explored potential approaches to treat or prevent BPA-induced testicular toxicity and male infertility. Since the effect of BPA on testicular cells and spermatozoa is associated with an increased production of reactive oxygen species, most of the pharmacological approaches are based on the use of natural or synthetic antioxidants.
    [Show full text]
  • The Phytochemistry of Cherokee Aromatic Medicinal Plants
    medicines Review The Phytochemistry of Cherokee Aromatic Medicinal Plants William N. Setzer 1,2 1 Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA; [email protected]; Tel.: +1-256-824-6519 2 Aromatic Plant Research Center, 230 N 1200 E, Suite 102, Lehi, UT 84043, USA Received: 25 October 2018; Accepted: 8 November 2018; Published: 12 November 2018 Abstract: Background: Native Americans have had a rich ethnobotanical heritage for treating diseases, ailments, and injuries. Cherokee traditional medicine has provided numerous aromatic and medicinal plants that not only were used by the Cherokee people, but were also adopted for use by European settlers in North America. Methods: The aim of this review was to examine the Cherokee ethnobotanical literature and the published phytochemical investigations on Cherokee medicinal plants and to correlate phytochemical constituents with traditional uses and biological activities. Results: Several Cherokee medicinal plants are still in use today as herbal medicines, including, for example, yarrow (Achillea millefolium), black cohosh (Cimicifuga racemosa), American ginseng (Panax quinquefolius), and blue skullcap (Scutellaria lateriflora). This review presents a summary of the traditional uses, phytochemical constituents, and biological activities of Cherokee aromatic and medicinal plants. Conclusions: The list is not complete, however, as there is still much work needed in phytochemical investigation and pharmacological evaluation of many traditional herbal medicines. Keywords: Cherokee; Native American; traditional herbal medicine; chemical constituents; pharmacology 1. Introduction Natural products have been an important source of medicinal agents throughout history and modern medicine continues to rely on traditional knowledge for treatment of human maladies [1]. Traditional medicines such as Traditional Chinese Medicine [2], Ayurvedic [3], and medicinal plants from Latin America [4] have proven to be rich resources of biologically active compounds and potential new drugs.
    [Show full text]
  • Discogenic Back Pain : the Induction and Prevention of a Pro-Inflammatory Cascade in Intervertebral Disc Cells in Vitro
    Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2013 Discogenic back pain : the induction and prevention of a pro-inflammatory cascade in intervertebral disc cells in vitro Quero, Lilian Abstract: Low back pain (LBP) is a prevalent symptom that more than 80% of the population experience once in their lifetime. This can lead to severe impairment of the workaday life and cause enormous costs in the society. Because LBP mostly appears as a non-specific back pain symptom, provoked by the spine or its environment, the evaluation of the source is bearing some challenge. Whereas the pathomorphological source of pain is well defined in the specific spinal pathology, such as in the caseofa scoliosis or sciatica, finding a correlation between the source of pain and a certain abnormality isdifficult in non-specific LPB symptoms. This is accompanied by the disadvantage of finding a suitable treatment. One possible source of LPB represents the intervertebral disc (IVD), which can alter from a pain free (asymptomatic) to a painful (symptomatic) IVD during degeneration, leading to so called discogenic back pain. Provocative discography is to date the only means to assign LBP to a degenerated disc, with its usage being under dispute. The IVD has an important function as a shock absorber, as there is a high load on the spine. During a lifetime, our IVD becomes degenerated which means its matrix is more catabolized then anabolized, leading to an overall matrix breakdown and decreased quality of the IVD. The matrix consists of long protein chains and sugars, responsible for the ability to attract water, comparable to a sponge.
    [Show full text]
  • High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors
    Biology 2014, 3, 101-138; doi:10.3390/biology3010101 OPEN ACCESS biology ISSN 2079-7737 www.mdpi.com/journal/biology Article High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors 1,† Jason Davenport 1, Maurie Balch 1, Lakshmi Galam , Antwan Girgis 2, Jessica Hall 2, Brian S. J. Blagg 2 and Robert L. Matts 1,* 1 Department of Biochemistry and Molecular Biology, 246 Noble Research Center, Oklahoma State University, Stillwater, OK 74078, USA; E-Mails: [email protected] (J.D.); [email protected] (M.B.); [email protected] (L.G.) 2 Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, KS 66045, USA; E-Mails: [email protected] (A.G.); [email protected] (J.H.); [email protected] (B.S.J.B.) † Current address: Department of Internal Medicine, University of South Florida School of Medicine, 12901 Bruce B. Downs Blvd. MDC 19, Tampa, FL 33612, USA. * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +1-405-744-6200; Fax: +1-405-744-7799. Received: 7 January 2014; in revised form: 22 January 2014 / Accepted: 22 January 2014 / Published: 10 February 2014 Abstract: Hsp90 has become the target of intensive investigation, as inhibition of its function has the ability to simultaneously incapacitate proteins that function in pathways that represent the six hallmarks of cancer. While a number of Hsp90 inhibitors have made it into clinical trials, a number of short-comings have been noted, such that the search continues for novel Hsp90 inhibitors with superior pharmacological properties.
    [Show full text]
  • Pseudocereal Grains: Nutritional Value, Health Benefits and Current Applications
    Pseudocereal grains: Nutritional value, health benefits and current applications for the development of gluten-free foods Cristina Martínez-Villaluenga 1, Elena Peñas 1, Blanca Hernández-Ledesma 2, * 1 Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. Email: [email protected]; [email protected] 2 Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM, CEI- UAM+CSIC), Nicolás Cabrera 9, 28049 Madrid, Spain. Email: [email protected] * Corresponding author. B. Hernández-Ledesma Tel.: +34 910017970; fax: +34 910017905. E-mail address: [email protected] Abbreviations: DIAAS, digestible indispensable amino acid scores; dw, dry weight; FDA, Food and Drug Administration; GF, gluten free; ICR, Institute of Cancer Research; IGF-1, insulin like growth factor; IL, interleukin; LDL, low density lipoproteins; LPS, lipopolysaccharide; NO, nitric oxide; PDCAAS, protein digestibility corrected amino acid score; POx, prolin oxidase; PUFAs, polyunsaturated fatty acids; RS, resistant starch; TNF-α, tumor necrosis factor-alpha. 1. Introduction Pseudocereals grains are edible seeds belonging to dicotyledonous species that are known as such due to their similar physical appearance and high starch content similar to true cereals (monocotyledonous of the Poaceae family) (Alvarez-Jubete et al., 2010a). Pseudocereals are promising crops of future due to their high genetic variability that is advantageous for them to be adapted to different environments from tropical to temperate climatic conditions (Joshi et al., 2018 and 2019; Ruiz et al., 2013). The most important species are quinoa ( Chenopodium quinoa Willd), amaranth ( Amaranthus sp.) and buckwheat (Fagopyrum sp.). Quinoa and amaranth belong to Chenopodiaceae family originated from the Andean region in South America.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 7,399,783 B2 Rosenbloom (45) Date of Patent: Jul
    US007399.783B2 (12) United States Patent (10) Patent No.: US 7,399,783 B2 Rosenbloom (45) Date of Patent: Jul. 15, 2008 (54) METHODS FOR THE TREATMENT OF SCAR Quercetin: Implications for the Treatment of Excessive Scars.” TSSUE Internet Web Page, vol. 57(5); Nov. 2004. Marilyn Sterling, R.D., Article: Science Beat, Internet Web Page, (75) Inventor: Richard A. Rosenbloom, Elkins Park, Natural Foods Merchandiser vol. XXIV, No. 10, p. 50, 2003. PA (US) Phan TT. See P. Tran E. Nguyen TT, Chan SY. Lee ST and Huynh H., PubMed, Internet Web Page, “Suppression of Insulin-like Growth (73) Assignee: The Quigley Corporation, Doylestown, Factor Signalling Pathway and Collagen Expression in Keloid-De rived Fibroblasts by Quercetin: It's Therapeutic Potential Use in the PA (US) Treatment and/or Prevention of Keloids.” Br. J. Dermatol., Mar. 2003, 148(3):544-52. (*) Notice: Subject to any disclaimer, the term of this Crystal Smith, Kevin A. Lombard, Ellen B. Peffley and Weixin Liu; patent is extended or adjusted under 35 "Genetic Analysis of Quercetin in Onion (Allium cepa L.) Lady U.S.C. 154(b) by 440 days. Raider.” The Texas Journal of Agriculture and Natural Resource, vol. 16 pp. 24-28, 2003. (21) Appl. No.: 11/158,986 Skin Actives Scientific L.L.C., Internet Web Page, “Quercetin.” Quercetin by Skinactives, printed on Apr. 10, 2006. (22) Filed: Jun. 22, 2005 Saulis, Alexandrina S. M.D.; Mogford, Jon H. Ph.D.; Mustoe, Tho mas A., M.D., Plastic and Reconstructive Surgery, “Effect of (65) Prior Publication Data Mederma on Hypertrophic Scarring in the Rabbit Ear Model.” Jour US 2006/O293257 A1 Dec.
    [Show full text]
  • Asteraceae)§ Karin M.Valant-Vetscheraa and Eckhard Wollenweberb,*
    Chemodiversity of Exudate Flavonoids in Seven Tribes of Cichorioideae and Asteroideae (Asteraceae)§ Karin M.Valant-Vetscheraa and Eckhard Wollenweberb,* a Department of Plant Systematics and Evolution Ð Comparative and Ecological Phytochemistry, University of Vienna, Rennweg 14, A-1030 Wien, Austria b Institut für Botanik der TU Darmstadt, Schnittspahnstrasse 3, D-64287 Darmstadt, Germany. E-mail: [email protected] * Author for correspondence and reprint requests Z. Naturforsch. 62c, 155Ð163 (2007); received October 26/November 24, 2006 Members of several genera of Asteraceae, belonging to the tribes Mutisieae, Cardueae, Lactuceae (all subfamily Cichorioideae), and of Astereae, Senecioneae, Helenieae and Helian- theae (all subfamily Asteroideae) have been analyzed for chemodiversity of their exudate flavonoid profiles. The majority of structures found were flavones and flavonols, sometimes with 6- and/or 8-substitution, and with a varying degree of oxidation and methylation. Flava- nones were observed in exudates of some genera, and, in some cases, also flavonol- and flavone glycosides were detected. This was mostly the case when exudates were poor both in yield and chemical complexity. Structurally diverse profiles are found particularly within Astereae and Heliantheae. The tribes in the subfamily Cichorioideae exhibited less complex flavonoid profiles. Current results are compared to literature data, and botanical information is included on the studied taxa. Key words: Asteraceae, Exudates, Flavonoids Introduction comparison of accumulation trends in terms of The family of Asteraceae is distributed world- substitution patterns is more indicative for che- wide and comprises 17 tribes, of which Mutisieae, modiversity than single compounds. Cardueae, Lactuceae, Vernonieae, Liabeae, and Earlier, we have shown that some accumulation Arctoteae are grouped within subfamily Cichori- tendencies apparently exist in single tribes (Wol- oideae, whereas Inuleae, Plucheae, Gnaphalieae, lenweber and Valant-Vetschera, 1996).
    [Show full text]
  • Feverfew (Tanacetum Parthenium L.): a Systematic Review
    Pharmacogn Rev. 2011 Jan-Jun; 5(9): 103–110. PMCID: PMC3210009 doi: 10.4103/0973-7847.79105 Feverfew (Tanacetum parthenium L.): A systematic review Anil Pareek, Manish Suthar,1 Garvendra S. Rathore,1 and Vijay Bansal Department of Pharmaceutical Science, L. M. College of Science and Technology (Pharmacy Wing), Jodhpur- 342 003, India 1Department of Pharmaceutical Science, L B S College of Pharmacy, Udai Marg, Tilak Nagar, Jaipur - 302 004, Rajasthan, India Address for correspondence: Mr. Anil Pareek, Department of Pharmaceutical Science, L. M. College of Science and Technology (Pharmacy Wing), Jodhpur- 342 003, Rajasthan, India. E-mail: [email protected] Received March 22, 2010; Revised March 23, 2010 Copyright © Pharmacognosy Reviews This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Abstract Go to: Feverfew (Tanacetum parthenium L.) (Asteraceae) is a medicinal plant traditionally used for the treatment of fevers, migraine headaches, rheumatoid arthritis, stomach aches, toothaches, insect bites, infertility, and problems with menstruation and labor during childbirth. The feverfew herb has a long history of use in traditional and folk medicine, especially among Greek and early European herbalists. Feverfew has also been used for psoriasis, allergies, asthma, tinnitus, dizziness, nausea, and vomiting. The plant contains a large number of natural products, but the active principles probably include one or more of the sesquiterpene lactones known to be present, including parthenolide.
    [Show full text]