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Forkheads in neuroblastoma & human longevity: From the womb to the tomb
Santo, E.E.
Publication date 2015 Document Version Final published version
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Citation for published version (APA): Santo, E. E. (2015). Forkheads in neuroblastoma & human longevity: From the womb to the tomb.
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UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:01 Oct 2021
Forkheads In Neuroblastoma & Human Longevity:
From The Womb To The Tomb
Evan Edward Santo Copyright © 2015 by E.E. Santo.
All rights reserved. No part of this book may be reproduced or retransmitted in any form or by any means without the expressed written consent of the author.
“Forkheads In Neuroblastoma & Human Longevity: From The Womb To The Tomb”
The research presented in this thesis was performed at the Department of Oncogenomics, Academic Medical Center (AMC), University of Amsterdam, The Netherlands from April 2007 – June 2014.
Printing of this thesis was financially supported by the Academic Medical Center (AMC), University of Amsterdam.
Layout: E.E. Santo Cover design: E.E. Santo Printing: Off Page, www.offpage.nl Forkheads In Neuroblastoma & Human Longevity:
From The Womb To The Tomb
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof.dr. D.C. van den Boom ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op woensdag 21 oktober 2015, te 12.00 uur
door
Evan Edward Santo geboren te New York, Verenigde Staten Promotiecommissie
Promotor: Prof.dr. R. Versteeg Universiteit van Amsterdam
Co-promotor: Dr. E.M. Westerhout Universiteit van Amsterdam
Overige leden: Prof.dr.ir. B.M.T. Burgering Universiteit Utrecht Prof.dr. P.J. Coffer Universiteit Utrecht Prof.dr. J.P. Medema Universiteit van Amsterdam Prof.dr. A. Vaag Universiteit van Kopenhagen Prof.dr. A.J. Verhoeven Universiteit van Amsterdam Prof.dr. R.J.A. Wanders Universiteit van Amsterdam
Faculteit der Geneeskunde Table Of Contents
Chapter 1 Introduction 1
Chapter 2 Oncogenic Activation Of FOXR1 By 11q23 Intrachromosomal 59 Deletion-Fusions In Neuroblastoma
Chapter 3 FOXO3a Is A Major Target Of Inactivation By PI3K/AKT 89 Signaling In Aggressive Neuroblastoma
Chapter 4 Inhibition of PI3K/Akt Signaling and A PI3K-independent 127 mTORC1 Activity Synergistically Induces Apoptosis In Neuroblastoma
Chapter 5 FOXO3A2, A New Isoform of FOXO3A, Differentially 157 Regulates Glycolysis Depending On A Longevity SNP In Its 5pUTR
Chapter 6 General Discussion 189
Chapter 7 Summary / Samenvatting 205 Summary 207 Samenvatting 211
Acknowledgements 215 Curriculum Vitae 219 List Of Publications 221