Supplemental Table III 2 Fold Change decreases in AireKO1

UniGene ID Build 167 (28 Expression Oct 2007) / profile (Unigene Norm Norm FC Probe Set ID Representative Symbol Gene Name tissues 03.2008) wt ko Public ID Mm.440886 Klk1 / Klk1b1 / kallikrein 1-related peptidase b9 / 94716_f_at Klk1b4 / Klk1b9 b1 / kallikrein 1 1 salivary gland 0.47 1.18 2.50 Mm.464562 Mup1 / Mup2 / Mup3 / Mup4 / 102096_f_at Mup5 / major urinary 1/ 2 / 3 / 4 / 5 1 embryo 0.46 1.05 2.28 93879_f_at Mm.436573 Defcr3 defensin related cryptdin 3 1 intestine 0.38 1.93 5.08 Mm.436573 Defcr17 / Defcr23 / defensin related cryptdin 3 / 6 / 17 93863_f_at Defcr24 / 23 / 24 / 1 intestine 0.43 1.43 3.34 Mm.305275 Defcr-rs1 / Defcr17 / Defcr20 / Defcr23 / Defcr24 / Defcr26 / Defcr3 defensin related cryptdin 3 / 4 / 6 / 92812_f_at / Defcr4 / Defcr6 17 / 20 / 23 / 24 / 26 1 intestine 0.27 2.03 7.47 Mm.422993 defensin related cryptdin, related Defcr-rs10 / sequence 10 / defensin related 94738_s_at Defcr-rs2 cryptdin, related sequence 2 1 intestine 0.13 1.51 11.80 Mm.86948 eosinophil-associated, 100311_f_at Ear1 A family, member 1 1 embryo 0.55 1.38 2.52 98826_at Mm.4956 Fgf4 fibroblast 4 1 embryo 0.62 1.29 2.09 94086_at Mm.983 Il3 3 1 thymus 0.38 1.09 2.91 Mm.200411 mucin 10, submandibular gland 101139_r_at Muc10 salivary mucin 1 salivary gland 0.17 0.89 5.33 101635_f_at Mm.445286 Mup5 major urinary protein 5 1 0.22 1.79 8.08 100437_g_at Mm.14173 Orm1 / Orm2 orosomucoid 1 / orosomucoid 2 1 liver 0.38 1.79 4.70 94734_at Mm.14173 Orm2 orosomucoid 2 0.48 0.98 2.05 162464_f_at Mm.1269 Ppy Pancreatic polypeptide 1 pancreas 0.57 1.64 2.86 94148_at Mm.1269 Ppy pancreatic polypeptide 0.30 2.09 7.10 93208_at Mm.449428 Prss1 , serine, 1 (trypsin 1) 1 pancreas 0.20 2.00 10.12 Mm.272188 serine (or cysteine) peptidase 103306_at Serpinb6c inhibitor, clade B, member 6c 1 embryo 0.22 0.57 2.54 93941_at Mm.913 T brachyury 1 ovary 0.08 1.13 14.98 Mm.391342 molar, pituitary 94707_s_at Amelx amelogenin X 2 gland 0.17 2.38 13.88 Mm.1361 glycoprotein , alpha ovum, pituitary 162502_f_at Cga subunit 2 gland 0.71 1.80 2.55 Mm.1361 glycoprotein hormones, alpha 94700_at Cga subunit 0.28 0.80 2.86 Mm.27982 developmental pluripotency- 97283_at Dppa3 associated 3 2 ovum, ovary 0.67 2.17 3.26 Mm.139314 developmental pluripotency 160370_at Dppa5 associated 5 2 ovary, testis 0.51 1.40 2.75 92377_at Mm.389604 Gm1060 gene model 1060, (NCBI) 2 brain, testis 0.68 1.50 2.21 Mm.4946 intestine, 100150_f_at Ins2 II 2 pancreas 0.12 2.85 24.10 101698_f_at Mm.358616 Krt2 2 2 brain, skin 0.47 1.49 3.14 98954_f_at Mm.472892 Oog1 oogenesin 1 2 ovum, ovary 0.19 0.79 4.15 99958_at Mm.4409 Mcpt2 mast cell protease 2 2 blood, intestine 0.04 1.35 31.22 101174_at Mm.270533 Ocm 2 eye, inner ear 0.24 1.84 7.71 Mm.2552 intestine, 103954_at Reg3a regenerating islet-derived 3 alpha 2 pancreas 0.25 0.69 2.77 98837_at Mm.5033 Rln1 relaxin 1 2 mammary 0.40 1.43 3.52

1 Differentially regulated transcripts between knockout and wild-type mTECs for two-fold change in expression level as analyzed in GeneSpring software, with data normalized per gene and per chip and without filtering in expression level. TSAs are organized according to their known expression profile (Unigene database) from transcripts expressed in the lowest (1) to the highest (5) number of different tissues. gland, uterus Mm.306720 complement component 4 binding epididymis, 102799_at C4bp protein 3 , liver 0.49 1.45 2.94 Mm.4908 brain, lung, 100463_at Csn1s2a casein alpha s2-like A 3 mammary gland 0.20 2.04 10.04 Mm.15537 cytochrome P450, family 1, liver, lung, 102998_at Cyp1a2 subfamily a, polypeptide 2 3 muscle 0.12 1.86 16.12 Mm.14098 mammary cytochrome P450, family 2, gland, pituitary 102690_at Cyp2b19 subfamily b, polypeptide 19 3 gland, skin 0.59 1.59 2.71 Mm.440885 intestine, 97681_f_at Gstm3 glutathione S-transferase, mu 3 3 kidney, liver 0.36 2.42 6.65 Mm.415 eye, pancreas, 99488_at Iapp islet amyloid polypeptide 3 thymus 0.50 1.88 3.76 Mm.5193 kidney, mammary gand, 101289_f_at Klk1b22 kallikrein 1-related peptidase b22 3 salivary gland 0.50 1.17 2.34 Mm.441685 / hypothetical protein ovum, ovary, 103992_f_at AA636966 LOC100044146 LOC100044146 3 testis 0.43 1.51 3.47 Mm.3207 spinal cord, 104667_at Lrrc23 leucine rich repeat containing 23 3 thymus, testis 0.55 1.68 3.04 Mm.391556 mucosal vascular addressin cell intestine, LN, 102680_g_at Madcam1 adhesion molecule 1 3 spleen 0.67 1.58 2.37 Mm.457982 Eye, liver, 101682_f_at Mup4 major urinary protein 4 3 salivary gland 0.13 2.11 16.52 Mm.2740 extraembr natriuretic peptide precursor type tissue, heart, 104184_at Nppb B 3 testis 0.13 1.23 9.62 Mm.1433 bladder, brain, 162037_f_at Npy2r neuropeptide Y receptor Y2 3 intestine 0.51 1.30 2.54 Mm.25804 innear ear, 93570_at Slc12a3 solute carrier family 12, member 3 3 kidney, spleen 0.23 0.79 3.46 Mm.140151 skin, stomach, 100445_f_at Sprr1b small proline-rich protein 1B 3 tongue 0.56 1.57 2.81 Mm.42139 brain, inner ear, 98301_at Tectb tectorin beta 3 liver 0.12 0.99 8.32 Mm.249221 tumor necrosis factor (ligand) bone, spleen, 93416_at Tnfsf11 superfamily, member 11 3 thymus 0.13 0.70 5.31 Mm.1381 ovum, liver, 102675_at Zp3 zona pellucida glycoprotein 3 3 ovary 0.17 1.11 6.47 Mm.27096 extraembr CEA-related tissue, eye, 104159_at Ceacam9 molecule 9 4 ovary, uterus 0.25 1.04 4.12 Mm.427467 brain, eye, lung, 96030_at Csn1s1 casein alpha s1 4 mammary gland 0.05 2.90 58.57 Mm.21300 extraembr insulin-like growth factor binding tissue, kidney, 103896_f_at Igfbp1 protein 1 4 liver, muscle 0.65 1.67 2.59 Mm.447819 intestine, salivary gland, 95775_f_at Klk1b1 kallikrein 1-related peptidase b1 4 skin, testis 0.47 1.19 2.54 Mm.25292 ovum, ovary, 162328_f_at Krt84 keratin 84 4 skin, tongue 0.70 1.55 2.21 Mm.1536 stomach, testis, 102989_at Mt4 metallothionein 4 4 tongue, uterus 0.24 2.90 12.19 Mm.2553 intestine, pancreas, stomach, 161890_f_at Pap pancreatitis-associated protein 4 thymus 0.32 2.38 7.54 96009_s_at Mm.2553 Pap pancreatitis-associated protein 0.34 1.99 5.87 Mm.277996 brain, pituitary gland, skin, 94026_at Pomc1 pro-opiomelanocortin-alpha 4 testis 0.23 1.73 7.66 Mm.200941 liver, lung, mammary 103465_f_at Saa2 serum amyloid A 2 4 gland, testis 0.62 1.48 2.40 Mm.10692 eye, stomach, 94120_s_at Sprr2f small proline-rich protein 2F 4 uterus, vagina 0.35 2.44 6.89 Mm.2374 eye, inner ear, pancreas, 103548_at Tac2 tachykinin 2 4 uterus 0.18 1.94 10.99 Mm.902 liver, mammary gland, skin, 101912_at 1100001G20Rik RIKEN cDNA 1100001G20 gene 5 spleen, stomach 0.68 1.57 2.32 Mm.458383 adrenal gland, liver, mammary major urinary protein 1 / major gland, muscle, 101566_f_at Mup1 / Mup2 urinary protein 2 5 stomach 0.30 1.91 6.44 Mm.458383 adrenal gland, liver, mammary Mup1 / Mup2 / gland, muscle, 161815_f_at Mup3 major urinary protein 1 / 2 / 3 5 stomach 0.19 2.58 13.74 Mm.1252 BM, heart, mammary gland, skin, 102407_at Cma1 chymase 1, mast cell 5 thymus 0.06 0.82 13.87 Mm.22126 intestine, liver, lung, muscle, 94075_at Fabp1 fatty acid binding protein 1, liver 5 stomach 0.44 1.35 3.08 Mm.28398 BM, intestine, fatty acid binding protein 2, liver, pancreas, 97889_at Fabp2 intestinal 5 stomach 0.20 2.22 11.10 Mm.292992 brain, eye, skin, spinal cord, 94447_at Krt77 keratin 77 5 thymus 0.60 1.20 2.01 Mm.5023 brain, eye, pancreas, prostate, spinal 160899_at Pcp4 Purkinje cell protein 4 5 cord 0.16 2.17 13.73 Mm.1280 BM, eye, salivary gland, 162108_f_at Spt1 salivary protein 1 5 testis, thymus 0.19 1.99 10.72 94152_at Mm.1280 Spt1 salivary protein 1 0.07 1.97 26.38 Mm.4641 extraembr tissue, heart, intestine, liver, 100106_at Tff3 trefoil factor 3, intestinal 5 pancreas 0.09 2.80 31.06 Mm.383529 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:6530415D11 product:unclassifiable, full insert 161050_at --- sequence 0.47 1.41 2.97 97413_at Mm.29959 1600029D21Rik RIKEN cDNA 1600029D21 gene 0.49 1.82 3.69 96779_f_at Mm.29063 2410022L05Rik RIKEN cDNA 2410022L05 gene 0.61 1.38 2.27 161005_at Mm.28129 5730420B22Rik RIKEN cDNA 5730420B22 gene 0.73 1.72 2.35 Mm.23044 9630050M13Rik RIKEN cDNA 9630050M13 gene / / hypothetical protein 160963_at LOC100045420 LOC100045420 0.65 1.40 2.17 104486_at Mm.30151 A2m alpha-2-macroglobulin 0.30 0.79 2.64 Mm.245724 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3- 95064_at Acaa2 oxoacyl-Coenzyme A thiolase) 0.91 2.00 2.21 Mm.7044 acyl-CoA synthetase short-chain 160921_at Acss1 family member 1 0.64 1.32 2.08 Mm.213025 , alpha 2, smooth muscle, 93100_at Acta2 aorta 0.22 2.07 9.21 Mm.686 Actc1 / actin, alpha, cardiac / similar to 101028_i_at LOC100048431 alpha-actin (AA 27-375) 0.18 0.55 3.04 Mm.330692 S-adenosylhomocysteine 96025_g_at Ahcy 0.68 1.86 2.74 101531_at Mm.218862 Aldob aldolase 2, B isoform 0.71 1.55 2.18 101532_g_at Mm.218862 Aldob aldolase 2, B isoform 0.36 1.40 3.90 94045_at Mm.2197 Ambp alpha 1 microglobulin/bikunin 9 0.13 1.65 12.61 160131_at Mm.21145 Amotl2 angiomotin like 2 0.45 1.00 2.21 103688_at Mm.145208 Ankrd43 repeat domain 43 9 0.48 1.69 3.54 161703_f_at Mm.248360 Anxa1 A1 0.69 1.52 2.19 93038_f_at Mm.248360 Anxa1 0.61 1.23 2.01 97529_at Mm.3267 Anxa8 annexin A8 0.81 1.64 2.03 96094_at Mm.26743 Apoa1 apolipoprotein A-I 0.37 2.02 5.45 93330_at Mm.18625 Aqp1 1 0.32 0.88 2.77 102704_at Mm.250786 Aqp4 aquaporin 4 0.38 1.13 3.01 92294_at Mm.314378 Arl5a ADP-ribosylation factor-like 5A 0.37 0.76 2.05 Mm.6306 ATPase, Ca++ transporting, 103935_at Atp2a3 ubiquitous 0.47 1.42 2.98 93021_at Mm.336245 Bex4 brain expressed gene 4 0.56 1.41 2.52 101078_at Mm.726 Bsg basigin 0.62 1.29 2.07 103570_at Mm.280158 C1qtnf3 C1q and tumor necrosis factor 0.11 0.94 8.68 related protein 3 Mm.333375 complement component 1, r 95415_f_at C1r subcomponent 0.59 1.35 2.28 Mm.439733 calcium/-dependent 100453_at Camk2b protein II, beta 8 0.52 1.19 2.29 92322_at Mm.3834 Camp cathelicidin antimicrobial peptide 7 0.54 2.06 3.82 92208_at Mm.150568 Caprin2 caprin family member 2 0.61 1.53 2.48 102773_at Mm.119320 Car8 carbonic anhydrase 8 0.45 1.03 2.29 162138_s_at Mm.38438 Cbx6 chromobox homolog 6 0.64 1.56 2.43 102424_at Mm.1282 Ccl3 chemokine (C-C motif) ligand 3 0.66 1.36 2.06 104388_at Mm.416125 Ccl9 chemokine (C-C motif) ligand 9 0.65 1.58 2.45 98088_at Mm.3460 Cd14 CD14 antigen 0.62 1.66 2.67 162097_r_at Mm.4658 Cdh3 3 0.55 1.26 2.31 Mm.168789 cyclin-dependent kinase inhibitor 95471_at Cdkn1c 1C (P57) 0.86 1.94 2.25 Mm.279308 CHK2 checkpoint homolog (S. 92481_at Chek2 pombe) 0.67 1.37 2.04 92841_f_at Mm.255241 Chgb chromogranin B 0.36 1.57 4.42 99952_at Mm.38274 Chi3l1 chitinase 3-like 1 0.59 1.42 2.40 Mm.334584 cartilage intermediate layer protein 95374_f_at Cilp2 2 10 0.69 1.53 2.23 Mm.454553 calcium activated 103812_at Clca1 1 0.80 1.61 2.02 Mm.33483 chloride channel calcium activated 162287_r_at Clca3 3 7 0.41 1.63 3.96 161294_f_at Mm.200608 Clu clusterin 0.65 1.55 2.39 Mm.150064 CKLF-like MARVEL transmembrane domain 104626_at Cmtm8 containing 8 0.66 1.37 2.07 103709_at Mm.458212 Col1a1 procollagen, type I, alpha 1 0.58 1.20 2.06 98518_f_at Mm.35806 Crct1 cysteine-rich C-terminal 1 7 0.40 1.80 4.46 Mm.22574 colony stimulating factor 1 104354_at Csf1r receptor 0.44 1.16 2.64 103341_at Mm.1815 Ctps cytidine 5'-triphosphate synthase 0.75 1.50 2.00 160421_r_at Mm.34374 Ctrb1 chymotrypsinogen B1 0.54 1.63 3.00 102025_at Mm.10116 Cxcl13 chemokine (C-X-C motif) ligand 13 0.45 1.07 2.37 98772_at Mm.4660 Cxcl5 chemokine (C-X-C motif) ligand 5 0.55 1.52 2.74 103423_at Mm.149403 Cyb561 cytochrome b-561 0.55 1.25 2.28 Mm.1840 cytochrome P450, family 4, 103353_f_at Cyp4b1 subfamily b, polypeptide 1 0.41 1.22 2.98 Mm.245297 cytochrome P450, family 4, 160611_at Cyp4v3 subfamily v, polypeptide 3 0.78 1.69 2.18 Mm.21389 bladder, brain, connective tissue, eye, inner ear, 103438_at Dio2 deiodinase, iodothyronine, type II 6 mammary gland 0.15 0.90 5.84 Mm.4138 deleted in malignant brain tumors 99479_at Dmbt1 1 9 0.45 1.91 4.27 103031_g_at Mm.44736 Dnm1 1 10 0.68 1.43 2.09 161171_at Mm.39725 Dusp8 dual specificity 8 10 0.50 1.07 2.12 92362_at Mm.39725 Dusp8 dual specificity phosphatase 8 0.47 1.48 3.15 Mm.260256 eukaryotic translation initiation 103926_at Eif4g1 factor 4, gamma 1 0.35 0.93 2.66 102373_at Mm.1193 Enpep glutamyl aminopeptidase 0.38 1.39 3.69 Mm.250256 ectonucleotide pyrophosphatase/phosphodiestera 97317_at Enpp2 se 2 0.42 1.60 3.77 103051_at Mm.1650 Expi extracellular proteinase inhibitor 10 0.50 1.41 2.79 101090_at Mm.271644 Fbn1 fibrillin 1 0.44 1.07 2.40 96918_at Mm.271644 Fbp1 fructose bisphosphatase 1 0.18 1.13 6.34 96868_at Mm.30063 Fgb fibrinogen, B beta polypeptide 9 0.03 0.95 33.30 162171_f_at Mm.16340 Fgfr2 fibroblast 2 0.18 0.45 2.47 93096_at Mm.16422 Fgg fibrinogen, gamma polypeptide 10 0.12 1.99 16.12 Mm.329322 formin homology 2 domain 104255_at Fhod3 containing 3 10 0.51 1.55 3.06 Mm.976 flavin containing monooxygenase 101991_at Fmo1 1 0.57 2.03 3.56 Mm.263847 FXYD domain-containing ion 103059_at Fxyd3 transport regulator 3 0.55 1.69 3.07 100407_at Mm.4655 Gal galanin 8 0.63 1.63 2.57 94338_g_at Mm.207360 Gas2 growth arrest specific 2 0.18 0.74 4.11 96336_at Mm.29975 Gatm glycine amidinotransferase (L- 0.38 1.72 4.49 arginine:glycine amidinotransferase) Mm.439718 guanylate nucleotide binding 103202_at Gbp3 protein 3 0.65 1.71 2.61 160873_at Mm.379095 Ghrl ghrelin 9 0.20 0.94 4.72 99141_at Mm.287807 Gm2a GM2 ganglioside activator protein 0.42 1.28 3.07 Mm.210196 glycerol-3-phosphate 101867_at Gpam acyltransferase, mitochondrial 0.61 1.41 2.29 101676_at Mm.200916 Gpx3 glutathione peroxidase 3 0.65 1.99 3.07 Mm.28646 receptor DNA 96208_at Grlf1 binding factor 1 0.38 1.26 3.29 Mm.422778 glutathione S-transferase, alpha 2 101872_at Gsta2 (Yc2) 8 0.58 1.35 2.31 96085_at Mm.2662 Gsta4 glutathione S-transferase, alpha 4 0.55 1.47 2.66 93543_f_at Mm.37199 Gstm1 glutathione S-transferase, mu 1 0.74 1.49 2.02 100630_f_at Mm.282351 Gstm5 glutathione S-transferase, mu 5 0.78 1.78 2.28 97819_at Mm.378931 Gsto1 glutathione S-transferase omega 1 0.70 2.02 2.88 Mm.469944 / 93028_at X58196 H19 H19 fetal liver mRNA 0.24 1.93 7.94 Mm.440164 Hbb-y / hemoglobin Y, beta-like embryonic 97180_f_at LOC100044141 chain / similar to beta-globin 0.11 2.89 27.48 96672_at Mm.181852 Hod homeobox only domain 0.63 1.47 2.32 96092_at Mm.26730 Hp haptoglobin 0.55 1.72 3.16 94774_at Mm.218770 Ifi202b interferon activated gene 202B 0.51 1.09 2.15 Mm.136224 interferon induced with helicase C 103446_at Ifih1 domain 1 0.61 1.51 2.48 Mm.2036 interferon-induced protein with 103639_at Ifit2 tetratricopeptide repeats 2 0.62 1.43 2.29 98623_g_at Mm.3862 Igf2 insulin-like growth factor 2 0.16 2.82 17.59 Mm.29254 insulin-like growth factor binding 95082_at Igfbp3 protein 3 0.56 1.90 3.38 Mm.405761 insulin-like growth factor binding Igfbp5 / protein 5 / transmembrane protein 100566_at Tmem119 119 0.40 1.91 4.76 Mm.358609 insulin-like growth factor binding 103904_at Igfbp6 protein 6 0.49 1.33 2.71 Mm.218889 inositol monophosphatase domain 95458_s_at Impad1 containing 1 0.69 1.39 2.00 103714_at Mm.24153 Iyd iodotyrosine deiodinase 7 0.33 1.07 3.21 Mm.272239 potassium inwardly-rectifying 99974_at Kcnj15 channel, subfamily J, member 15 0.82 2.02 2.45 161856_f_at Mm.258846 Kif20a family member 20A 0.58 1.34 2.32 97937_at Mm.30262 Klf5 Kruppel-like factor 5 0.39 1.69 4.30 100061_f_at Mm.142722 Klk1 kallikrein 1 0.50 1.23 2.48 92353_at Mm.3944 Klk6 kallikrein related-peptidase 6 8 0.12 1.15 9.78 93837_at Mm.2160 Kng1 kininogen 1 10 0.72 1.50 2.08 94321_at Mm.22662 Krt10 0.70 1.74 2.49 92550_at Mm.439699 Krt19 0.78 2.15 2.77 100421_at Mm.46425 Krt4 9 0.62 1.58 2.55 104369_at Mm.302399 Krt6a 9 0.74 1.59 2.15 92759_at Mm.435441 Lamb3 , beta 3 0.42 1.52 3.60 160221_at Mm.390793 Lgals2 lectin, galactose-binding, soluble 2 7 0.53 1.43 2.71 Mm.15793 T-cell specific GTPase / LOC100039796 hypothetical protein 102906_at / Tgtp LOC100039796 0.61 1.74 2.85 Mm.458089 lymphocyte antigen 6 complex, LOC100041546 locus C1 / similar to Lymphocyte / antigen 6C precursor (Ly-6C) / LOC100045833 lymphocyte antigen 6 complex, 93077_s_at / Ly6c1 / Ly6c2 locus C2 8 0.73 1.84 2.53 Mm.298283 LOC100045304 , heavy polypeptide / 103234_at / Nefh similar to neurofilament protein 0.62 1.35 2.16 Mm.439693 Serpina1a / serine (or cysteine) peptidase Serpina1b / inhibitor, clade A, member 1a / Serpina1c / member 1b / member 1c / 93109_f_at Serpina1d member 1d 0.50 1.23 2.46 Mm.21855 peptidoglycan recognition protein 162475_f_at Pglyrp1 1 0.45 1.50 3.35 Mm.88796 Prl2c2 / Prl2c3 / prolactin family 2, subfamily c, 94838_r_at Prl2c4 member 2 / member 3 / member 4 7 0.15 0.49 3.21 Mm.34497 B4 12- 98440_at Ltb4dh hydroxydehydrogenase 0.38 1.93 5.02 101115_at Mm.282359 Ltf lactotransferrin 0.09 2.01 22.20 102061_at Mm.10414 Mlf1 myeloid leukemia factor 1 9 0.16 1.81 11.01 Mm.288898 myeloid/lymphoid or mixed lineage-leukemia translocation to 103925_at Mllt3 3 homolog (Drosophila) 0.83 1.69 2.03 96540_at Mm.426224 Mlph melanophilin 0.61 1.66 2.71 95339_r_at Mm.2055 Mmp12 matrix metallopeptidase 12 0.57 1.31 2.27 100484_at Mm.5022 Mmp13 matrix metallopeptidase 13 10 0.24 1.09 4.47 101909_f_at Mm.250267 Mup3 major urinary protein 3 8 0.23 2.20 9.63 101910_f_at Mm.250267 Mup3 major urinary protein 3 0.15 1.93 12.71 Mm.440598 v-myc myelocytomatosis viral oncogene homolog 1, lung 102235_at Mycl1 carcinoma derived (avian) 0.57 1.53 2.67 95347_at Mm.458718 Myt1 myelin transcription factor 1 10 0.68 1.46 2.15 96900_at Mm.333849 Ndg2 Nur77 downstream gene 2 0.68 1.43 2.09 101059_at Mm.400253 Ndn necdin 0.31 1.12 3.67 Mm.33773 NIMA (never in mitosis gene a)- 100885_at Nek2 related expressed kinase 2 0.79 1.65 2.10 96153_at Mm.236225 Ngp neutrophilic granule protein 0.24 2.22 9.40 161032_i_at Mm.154879 Nmu neuromedin U 7 0.43 1.47 3.40 Mm.24887 N-acetylneuraminate pyruvate 94330_at Npl lyase 0.38 1.50 3.92 Mm.206159 pyridoxal (pyridoxine, vitamin B6) 104320_at Pdxk kinase 0.54 1.28 2.38 96935_at Mm.30181 Pdzk1ip1 PDZK1 interacting protein 1 0.59 1.28 2.16 Mm.195898 phosphatidylethanolamine binding 162299_f_at Pebp1 protein 1 0.65 1.42 2.20 94516_f_at Mm.465218 Penk1 preproenkephalin 1 0.33 1.93 5.81 Mm.3117 pleckstrin homology-like domain, 160829_at Phlda1 family A, member 1 0.32 1.40 4.33 104201_at Mm.274842 Plac1 placental specific protein 1 7 0.68 1.37 2.01 98092_at Mm.34609 Plac8 placenta-specific 8 0.55 1.59 2.90 95368_at Mm.2251 Plxna2 plexin A2 0.50 1.16 2.33 160311_at Mm.267514 Plxnb2 plexin B2 0.41 1.23 3.03 Mm.16533 polymerase (RNA) II (DNA 103054_at Polr2a directed) polypeptide A 0.69 1.47 2.13 Mm.253614 peptidylprolyl isomerase 95111_i_at Ppil2 (cyclophilin)-like 2 0.13 0.47 3.66 93389_at Mm.6250 Prom1 prominin 1 0.35 2.01 5.76 93390_g_at Mm.6250 Prom1 prominin 1 0.30 1.43 4.73 92873_f_at Mm.276926 Prss2 protease, serine, 2 0.29 1.66 5.73 100080_at Mm.29197 Psp parotid secretory protein 8 0.16 1.42 8.90 102105_f_at Mm.1008 Ptgds D2 synthase (brain) 0.56 1.30 2.34 92545_f_at Mm.1008 Ptgds prostaglandin D2 synthase (brain) 0.32 2.22 6.88 96047_at Mm.2605 Rbp4 retinol binding protein 4, plasma 0.13 0.98 7.43 160896_at Mm.4876 Rcn1 reticulocalbin 1 0.75 1.51 2.02 Mm.142731 intestine, liver, pancreas, spleen, stomach, 160213_at Reg1 regenerating islet-derived 1 6 thymus 0.56 1.50 2.68 Mm.252385 regenerating islet-derived 3 162187_f_at Reg3g gamma 7 0.57 1.71 3.02 98335_at Mm.148877 Rfc1 replication factor C (activator 1) 1 0.30 0.73 2.48 93766_at Mm.2118 Rgn 9 0.24 1.38 5.84 Mm.235538 ribonuclease, RNase A family, 1 98041_at Rnase1 (pancreatic) 9 0.17 0.78 4.63 Mm.24045 radical S-adenosyl methionine 104177_at Rsad2 domain containing 2 0.38 1.39 3.70 94545_at Mm.221275 Rtn1 reticulon 1 0.66 1.32 2.01 Mm.1 S100 calcium binding protein A10 92539_at S100a10 (calpactin) 0.63 1.46 2.32 Mm.21567 S100 calcium binding protein A8 103448_at S100a8 ( A) 0.52 2.91 5.58 Mm.2128 S100 calcium binding protein A9 103887_at S100a9 (calgranulin B) 0.40 2.82 7.10 102712_at Mm.14277 Saa3 serum amyloid A 3 0.68 1.43 2.10 Mm.2258 secretoglobin, family 1A, member 94291_at Scgb1a1 1 (uteroglobin) 0.49 2.10 4.28 Mm.312593 serine (or cysteine) peptidase 101574_f_at Serpina1e inhibitor, clade A, member 1e 8 0.30 0.74 2.51 Mm.3093 serine (or cysteine) peptidase 97487_at Serpine2 inhibitor, clade E, member 2 0.52 1.16 2.22 99081_at Mm.38888 Serping1 serine (or cysteine) peptidase 0.60 1.38 2.30 inhibitor, clade G, member 1 100024_at Mm.46014 Shroom3 shroom family member 3 0.62 1.64 2.65 Mm.30239 solute carrier family 39 (metal ion 97442_at Slc39a8 transporter), member 8 0.45 1.41 3.12 Mm.258596 solute carrier family 6 (neurotransmitter transporter, 103934_at Slc6a13 GABA), member 13 9 0.57 1.49 2.62 92315_at Mm.38192 Slfn4 schlafen 4 10 0.32 1.73 5.38 Mm.371583 secretory leukocyte peptidase 161650_at Slpi inhibitor 0.55 1.95 3.54 Mm.371583 secretory leukocyte peptidase 92858_at Slpi inhibitor 0.27 1.75 6.56 Mm.85410 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily 102062_at Smarcc1 c, member 1 0.75 1.58 2.12 99475_at Mm.4132 Socs2 suppressor of cytokine signaling 2 0.63 1.31 2.08 100009_r_at Mm.65396 Sox2 SRY-box containing gene 2 7 0.58 1.61 2.77 93475_at Mm.252722 Spef1 sperm flagellar 1 0.61 1.48 2.41 97519_at Mm.288474 Spp1 secreted phosphoprotein 1 0.44 1.49 3.35 160909_at Mm.331191 Sprr1a small proline-rich protein 1A 9 0.57 1.37 2.40 161026_s_at Mm.38674 Sytl4 -like 4 0.16 1.04 6.51 96978_at Mm.38674 Sytl4 synaptotagmin-like 4 0.52 1.30 2.50 102726_at Mm.1440 Tac1 tachykinin 1 0.43 1.70 3.98 Mm.439913 tumor-associated calcium signal 160651_at Tacstd2 transducer 2 0.59 1.53 2.59 160780_at Mm.440067 Tcf3 transcription factor 3 0.66 1.35 2.05 Mm.1825 trefoil factor 2 (spasmolytic protein 93302_at Tff2 1) 7 0.54 1.79 3.31 103257_at Mm.26088 Tmem56 transmembrane protein 56 0.59 1.32 2.24 161361_s_at Mm.358643 Tnnt1 T1, skeletal, slow 0.50 1.69 3.35 103494_at Mm.22270 Tspan8 tetraspanin 8 0.64 1.29 2.02 160461_f_at Mm.181860 Tubb6 , beta 6 0.81 1.84 2.29 Mm.281844 UDP glucuronosyltransferase 2 103227_at Ugt2b34 family, polypeptide B34 7 0.19 1.19 6.41 92606_at Mm.10865 Uox urate oxidase 8 0.15 1.35 9.25 100019_at Mm.158700 Vcan versican 0.28 0.86 3.11 104165_at Mm.27154 Vnn1 vanin 1 0.40 1.67 4.15 101470_at Mm.374877 Wdr78 WD repeat domain 78 0.59 1.34 2.29 Mm.31267 WW, C2 and coiled-coil domain 96518_at Wwc1 containing 1 0.61 1.56 2.54

Expressed in 1-2 tissues Expressed in 3-4 tissues Expressed in 5 tissues Expressed in more than 5 tissues

FC>4 FC>3