SURGICAL SOLUTIONS FOR RESEARCH

Anesthesia

Surgical Instruments

Physiological Monitoring

Temperature Control

Ventilators

SURGICAL ELECTROPHYSIOLOGY MOLECULAR PUMPS BEHAVIORAL SOLUTIONS MICRODIALYSIS REGENERATIVE ELECTROPORATION & CELL BIOLOGY SAMPLE PREP RESEARCH MEDICINE & ELECTROFUSION RESEARCH www.harvardapparatus.com

the most www.microdialysis.com comprehensive line for Surgical www.coulbourn.com Solutions www.hugo-sachs.de & more!

Harvard Apparatus is pleased to offer you a www.panlab.com comprehensive range of tools to meet your ever- changing research needs. Whether your focus involves cells, tissues, organs, or whole animal, Harvard Apparatus has the expertise to guide and support your studies. Having supplied tools for www.warneronline.com over 100 years, Harvard Apparatus and its brands have been cited over 850,000 times in Google Scholar, 10,000 of those in 2012 alone.

www.btxonline.com SURGICAL SOLUTIONS FOR RESEARCH

For the very first time, Harvard Apparatus brings you a comprehensive surgical catalog dedicated to the needs of assembling and maintaining a state-of-the-art surgical suite. From surgical instruments to vital signs monitors and ventilators, we have the tools and knowledge to ensure your procedures are successful. Harvard Apparatus has provided durable, high-quality German- made surgical tools to researchers for over a decade. We have recently expanded our offerings and introduced a wider range of tools specifically targeted for small animal surgeries. Expanded technical specifications along with improved photos are included for every surgical instrument to assist you in choosing just the right option. Harvard Apparatus surgical tools are forged and finished in Germany under ISO9001. Our surgical grade steel resists corrosion and maintains sharp edges for optimum precision. Surgical equipment such as operating tables, lights and magnifiers are essential to a well-prepared surgical suite. Harvard Apparatus offers many options to meet your application needs as well as your budget. Surgical tables available include heated, homeothermic and standard, as well as specially designed tables for mice and rats. Good lighting and magnification improves surgical technique and, in turn, What's Inside: surgical outcomes. Section Page Anesthesia is essential to any surgical procedure. Harvard Apparatus has manufactured and supported a full line of SURGICAL INSTRUMENTS...... 1 anesthesia products for nearly two decades. For this catalog, we have preconfigured the most common options, enabling you SURGICAL EQUIPMENT...... 57 to get started faster and easier. Should your application require a unique set-up, we continue to maintain our broad product SURGICAL PREPARATION...... 99 offering to meet the specifics of your surgeries. DELIVERY & SAMPLING...... 109 Vital signs monitoring plays a critical role in many surgical procedures. Surgeons rely on real-time physiological data to ANESTHESIA...... 157 assess the status of their subject and progress of their surgery. Harvard Apparatus offers a wide range of equipment to enable VENTILATORS...... 185 critical monitoring for many research species. By adding comprehensive vital sign monitoring to your surgical suite you VITAL SIGNS...... 197 can guarantee the best possible outcomes. NEUROSCIENCE...... 231 Harvard Apparatus has the expertise and scientific depth to help you select the right tools when you start, as well as GENERAL SURGICAL...... 253 the commitment to provide the technical support to help you succeed. INDEX...... 263

i NEW PRODUCT HIGHLIGHTS

NEW Warm Air Chamber NEW Vascular Access Harness™ for Rats and Mice The Harvard Apparatus Warm Air Chamber contains four individual animal containment chambers. This Chamber is a digitally The Vascular Access Harness™ (VAH™), an advancement on the controlled, fan-assisted heater and containment box. It contains a original Covance Infusion Harness, permits quick and aseptic sensor for monitoring air temperature. It is ideal for post-operative connection and disconnection of a catheterized rat or mouse and an recovery and preoperative warming for applications such as tail vein infusion tether. The VAH™ consists of a small external port (or two bleeding and cannulation for rats and mice. This product is a perfect ports, in the case of the dual channel model) housed in a harness addition to all small animal research and/or veterinary care core which is installed at the same time that the catheter is implanted. facilities. For more information, see page 87. The catheter is attached to a connector built into the port under the harness dome. For more information, see page 116.

NEW Super Exam 50® Surgical Lights NEW Harvard Apparatus Anesthesia Systems

The Super Exam 50® has a highly flexible, self-balancing arm Harvard Apparatus has supported researchers with their system. The horizontal and vertical movement is the best in its class. anesthesia systems for over a decade, and for the first time we have This light is available in a standard or LED model. The Super Exam compiled our most popular equipment together into complete, 50® uses the latest halogen technology for maximum light output easy-to-order non-rebreathing anesthesia systems–perfect for mice and color rendering. The LED technology in this highly engineered and rats. These systems are available in either mobile or tabletop optical system delivers the precisely controlled natural white configurations and can be customized to your specific application. light that is so important for an accurate examination. For more Our anesthesia systems can be setup to deliver anesthetic to information see page 95. an induction chamber, mask, stereotaxic frame or ventilator, or any combination of these options. Anesthetic can be delivered to a single animal or multiple animals simultaneously. For more information see pages 157-184. ii NEW PRODUCT HIGHLIGHTS

NEW Hugo Sachs Pressure Monitor & Limiter NEW Blood Flow, Blood Pressure and ECG Research Grade Systems Ventilating animals with traditional positive pressure ventilation can inadvertently damage lungs and alveoli, increasing animal recovery Introducing packaged system options for the measurement of blood time and mortality. This can be mitigated with diligent vital sign flow while simultaneously monitoring blood pressure and single- monitoring and pressure-controlled ventilation. A new Ventilation or multi-lead ECG for rodent to large animal subjects. Choose a Pressure Monitor & Limiter from Hugo Sachs Elektronik, as part of research grade system when you wish to record and collect data your ventilation paradigm, reduces animal mortality and improves in an automated fashion instead of recording values by hand every surgical outcomes. For more information, see page 189. few minutes. Using a Data Acquisition system such as PowerLab, the analog output of the Research Grade Monitoring system can be converted to digital data through the LabChart software. For more information, see pages 228.

NEW MouseOxPlus® Pulse Oximeter NEW Ultra-Precise Stereotaxic Instruments

The MouseOxPlus® Pulse Oximeter is the only pulse oximeter Offering increased resolution (10 µm), these instruments are ideal that is designed to work with neonatal mice through adult rats. for use in rat and mouse stereotaxic surgery where high accuracy It has a patented design to detect heart rates of 90-900 bpm. positioning is required. Up to 80 mm of ventral-dorsal, medial- The MouseOxPlus® easily allows researchers to titrate mechanical lateral and anterior-posterior travel with up to 90° angle adjustment ventilation and monitor depth of anesthesia. Options available in either the anterior-posterior or medial-lateral planes. Ultra- enable it to work in MRI environments, work with multiple animals Precise Manipulators are compatible with Stereotaxic Instruments and even add temperature monitoring. For more information, including the New Standard, Lab Standard, Just for Mouse and Just see page 202. for Mice models. Purchase a complete Ultra-Precise stereotaxic instrument or upgrade your existing stereotaxic instrument. For more information, see pages 232 & 240. Vascular Access Harness is a trademark of Instech Laboratories Inc. MouseOxPlus is a registered trademark of Starr Life Sciences.

iii PRECISION SURGICAL INSTRUMENTS

arvard Apparatus offers a full line of precise, convenience we have created surgical kits suitable high quality surgical tools ideal for animal for a wide variety of applications. We offer general Hand cellular research. These instruments are purpose kits as well as kits designed for specific made from certified surgical grade German steel. surgeries. These kits offer a significant cost savings They are forged and finished in a German ISO 9001 over the individual purchase price. facility. Magnification and proper lighting in a surgical Our selection of fine surgical instruments suite should not be overlooked. Magnification includes a wide variety of tweezers, is essential for better alignment of incision forceps, scissors, bone instruments, and closure. It provides improved vision, surgical and vascular clips and freedom of movement and helps lessen clamps, scalpels, retractors, fatigue. wound closure, vascular access instruments, and more. Protect your investment by taking care of your surgical instruments. Harvard Apparatus surgical Properly cleaning and maintaining instruments are available in your surgical tools is extremely several materials including important and far less costly than Stainless Steel, Tungsten Carbide, replacing instruments. Proper care Titanium, Diamond and UltraEdge. and maintenance includes cleaning, Stainless Steel is a popular choice, lubricating, sterilizing, and storing your but for your research another material instruments. This will ensure longevity may be a better option. Tungsten and optimum performance. Carbide scissors last almost two times longer than stainless steel. Titanium is over 40% Harvard Apparatus offers high quality and affordably lighter than equivalent stainless steel instruments, priced surgical tools and accessories to meet with better flexibility and strength. Titanium is also your needs as well as the expertise to assist you in 100% non-magnetic. their selection.

Harvard Apparatus surgical instruments are available for purchase individually, but for your

iv PRODUCT PAGE

Harvard Apparatus Surgical Kits...... 2-6 Bone Instruments...... 7 Scalpels, Knives & Hooks...... 8-9 Scalpels & Scalpel Blades...... 10-11 Scissors...... 12-20 Tweezers...... 21 Forceps...... 22-30 Hemostatic Forceps...... 31-34 Needle Holders...... 35-38 Suture & Needles...... 39-43 Wound Closure...... 44 Clamps, Probes & Clips...... 44-47 Retractors...... 48 Hot Bead Sterilizer...... 49 Instrument Trays...... 50-51 Surgical Wraps, Drapes & Towels...... 52 Instrument Cleaner & Lubricant...... 52 Sponges & Wax...... 53 Etched Tungsten Micro-Needles...... 54 Gemini Cautery System...... 54 Organ Cannulation...... 55 Decapitators...... 56

Tungsten Carbide - TC Tungsten carbide is tough, only a diamond edge or laser beam will work it. Therefore, over an extended period time no or negligible wear can be detected. • The TC edge on scissors gives a soft touch. Thus, less force is required in delicate procedures, reducing trauma to the tissue. • The Needle Holders are indestructible and firmly hold the needle, while keeping the needle surface smooth. The needle nestles into concave/convex pyramids, regardless of needle positioning, so that the needle does not rotate during surgery.

Titanium Titanium (Material No. 7035, 7165) is approximately 50% lighter than steel to minimize tissue trauma during operations. Titanium instruments are also corrosion-proof, rugged and antimagnetic.

Diamond Diamond-coated tweezers grip as no other can! Each tweezer is made of stainless steel and coated with extremely fine diamond particles on the inside tips. This tweezer should be used for special applications where gripping is essential.

UltraEdge Our UltraEdge Scissors warrant your careful consideration. The highest quality steel goes into forging of an extremely durable razor edge on one blade and the opposite edge has a wave serration. The result is a solid smooth cut. SURGICAL INSTRUMENTS SURGICAL www.harvardapparatus.com web [email protected]

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1-508-893-8999 Surgical Kit Suture without Needle, Silk Black Braid, 5-0, 100 yards Graefe Iris Forceps, Serrated, 10.0 cm, Straight, Points 0.7 mm Eye Scissors, 11.5 cm, Straight, Vessel Clip Vannas Eye Scissors, Spring Action Model Tübingen, 8.5 cm, Straight* Product Mouse Isolated Heart Special Cut Jeweler’s Forceps, 11.0 cm, No. 5, Angled, pkg. of 2 mm Vessel Clip, 4 mm Jaw Length, 0.75 Jaw Width, Locking Pressure 125 g Applying Forceps for 72-8816 Product Rat/Guinea Pig Isolated Heart Surgical Kit Black Braid, 4-0,Suture without Needle, Silk 100 yards Sharp/Sharp,Operating Scissors, 13.0 cm, Straight Dressing Forceps, 13.0 cm, Straight, Slender Castroviejo-Mini Eye Scissors Spring Action, 11.0 cm, Right Angled Graefe Iris Forceps, Serrated, 10.0 cm, Strongly Curved, Points 0.3 mm, pkg. of 2 HALSTEAD-MOSQUITO, Hemostatic Forceps, 12.5 cm, Straight, pkg. of 2 mm, Straight Dieffenbach Vessel Clip, 35 To order call The Tübingen model has a longer blade than the standard Vannas scissors. Kit Components: ST1 51-7680 ST1 72-8591 ST1 72-8440 ST1 72-8508 ST1 72-8999 ST1 72-8688 ST1 72-8816 ST1 72-8993 # Order ST1 72-8998 # Order Kit Components: ST1 51-7698 ST1 72-8402 ST1 72-8949 ST1 72-8497 ST1 72-8614 ST1 72-8973 ST1 72-8815 *Note:  Kit Surgical to This is an ideal starter kit for anyone who needs perform surgeries for isolated heart preparation on mice. Heart Mouse Isolated This is an ideal starter kit for anyone who needs to This is an ideal starter isolated heart preparation on perform surgeries for rats or guinea pigs. Isolated Pig Rat/Guinea Kit Heart Surgical SURGICAL KITS KITS SURGICAL

SURGICAL

INSTRUMENTS 2 *Note:  on mice. perform surgeriesforisolatedorganpreparation This isanidealstarterkitforanyonewhoneedsto Surgical Kit Mouse Isolated Organ rats orguineapigs. perform surgeriesforisolatedorganpreparationon This isanidealstarterkitforanyonewhoneedsto Organ Surgical Kit Rat/Guinea PigIsolated ST1 72-8598 ST1 72-8508 ST1 72-8973 ST1 72-8966 ST1 72-8440 ST1 72-8591 ST1 51-7680 Kit Components: ST1 72-8997 Order # ST1 72-8960 ST1 72-8976 ST1 72-8600 ST1 72-8428 ST1 72-8949 ST1 72-8402 ST1 51-7698 Kit Components: ST1 72-8996 Order # To order call standard Vannasscissors. The Tübingenmodelhasalongerblade thanthe 1-508-893-8999 Points 0.5mm Graefe IrisForceps,Serrated,7.0cm, Curved Tübingen, 8.5cm,Straight* Vannas EyeScissors,SpringActionModel 12.5 cm,Straight HALSTEAD-MOSQUITO, HemostaticForceps, Forceps, 10.0cm,Curved MICRO-MOSQUITO, Hemostatic Eye Scissors,11.5cm,Straight,SpecialCut Straight, Points0.7mm Graefe IrisForceps,Serrated,10.0cm, 100 yards Suture withoutNeedle,SilkBlackBraid,5-0, Mouse IsolatedOrganSurgicalKit Product 10.0 cm,Curved HARTMANN, HemostaticForceps, 14.0 cm,Straight HALSTEAD-MOSQUITO, HemostaticForceps, Points 1.0mm,pkg.of2 Graefe IrisForceps,Serrated,7.0cm,Curved, Eye Scissors,11.5cm,Straight Dressing Forceps,13.0cm,Straight,Slender Straight Operating Scissors,13.0cm,Sharp/Sharp, 100 yards Suture withoutNeedle,SilkBlackBraid,4-0, Rat/Guinea PigIsolatedOrganSurgicalKit Product

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1-508-893-8999 Extra Delicate Jaw Trephine Drill Bits, pkg. of 3 Anchor Screw Drill Bits, pkg. of 3 Anchor Screws, pkg. of 100 Tungsten Carbide Inserts, 12.0 cm, Product Rodent Microdialysis Surgical Kit Scalpel Blades No. 10, Sterile, pkg. of 100 Scalpel Handle, No. 3 Eye Scissors, 10.5 cm, Straight mm,Dieffenbach Vessel Clips, 35 Straight, pkg. of 2 Operating Scissors, 14.5 cm, Sharp/Blunt, Straight Vannas Eye Scissors, Spring Action Model Tübingen, 8.5 cm, Straight* Graefe Iris Forceps, Serrated, 10.0 cm, Curved, Points, 0.7 mm TC Derf Needle Holders with 12.0 cm, Sharp/Sharp, Curved Barraquer Needle Holder with Rachet and Round Handle, 14.0 cm, Straight TC Olsen-Hegar Needle Holders with Scissors with Tungsten-Carbide Inserts, 12.0 cm Adson Tissue Forceps, 12.0 cm, 1 x 2 Teeth, with Suture Platform, 2 Stoppings, 0.8 mm Eye Scissors, 11.5 cm, Straight Product Rodent Microsurgical Kit 11.0 cm,Jeweler’s Forceps, Titanium, Angle 45° No. 4, Extra Delicate Tips, Micro Forceps, 18.0 cm with Curved Suture Platform, 0.3 mm, Micro Forceps, 18.0 cm with Straight Suture Platform, 0.3 mm, 17.5 cm, Straight Gerald Dressing Forceps, Gerald Dressing Forceps, 17.5 cm, Curved Vannas Microscissors with Round Handle, To order call ST1 CMA7431058 ST1 CMA8003264 ST1 CMA7431021 # Order ST1 72-8994 Kit Components: ST1 72-8360 ST1 72-8350 ST1 72-8426 ST1 72-8815 ST1 72-8393 ST1 72-8696 ST1 72-8604 ST1 72-8884 ST1 72-0145 ST1 72-8898 ST1 72-8573 ST1 72-8428 # Order ST1 72-9042 Kit Components: ST1 72-0461 ST1 72-0443 ST1 72-0442 ST1 72-0141 ST1 72-0142 ST1 72-0144 This kit is an ideal starting point for microdialysis This kit is an ideal starting point for microdialysis studies on rodents. Kit Surgical Microdialysis Rodent This kit is an ideal starting point for anyone ideal starting point This kit is an on rodents. performing microsurgery Kit Microsurgical Rodent SURGICAL KITS KITS SURGICAL

SURGICAL

INSTRUMENTS 4 laboratory mice. point forsurgicalproceduresperformedon The MouseSurgicalKitisanidealstarting Mouse Surgical Kit laboratory rats. surgical procedurescommonlyperformedon The RatSurgicalKitisanidealstartingpointfor Rat Surgical Kit ST1 72-8912 ST1 ST1 72-8826 ST1 72-8918 ST1 72-8426 ST1 72-8604 ST1 72-8503 ST1 72-8696 ST1 72-8372 Kit Components: ST1 72-8943 Order # ST1 72-8912 ST1 72-8844 ST1 72-8919 ST1 72-8440 ST1 72-8604 ST1 72-8503 ST1 72-8696 ST1 72-8372 Kit Components: ST1 72-8942 Order # To order call 1-508-893-8999 Probe, 14.5cm,DoubleEnded,1mm Diameter Derf NeedleHolders,12.0cm Barraquer (Colibri)EyeSpecula,Small Eye Scissors,10.5cm,Straight Curved, Points,0.7mm Graefe IrisForceps,Serrated,10.0cm, Spring Action Vannas EyeScissors,8.5cm,Straight, with ExtraDelicatePoints Jeweler’s Forceps11.0cmNo.5, Sterile, pkg.of10 Disposable ScalpelswithPlasticHandleNo.11, Mouse SurgicalKit Product Probe, 14.5cm,DoubleEnded,1mmDiameter Scissors, 11.5cm Olsen-Hegar NeedleHolderwith Barraquer (Colibri)EyeSpecula,Large Eye Scissors,11.5cm,Straight,SpecialCut Points, 0.7mm Graefe IrisForceps,Serrated,10.0cm,Curved, Action Vannas EyeScissors,8.5cmStraight,Spring Delicate Points Jeweler’s Forceps11.0cmNo.5,withExtra Sterile, Boxof10 Disposable ScalpelswithPlasticHandleNo.11, Rat SurgicalKit Product email [email protected]

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Barraquer (Colibri) Eye Specula, Large Probes, 14.5 cm, Double Ended, 1 mm, Diamond Adson Tissue Forceps, 12.0 cm, 1 x 2 Teeth Eye Scissors, 11.5 cm, Straight, Special Cut Graefe Iris Forceps, Serrated, 7.0 cm, Curved, Points 0.5 mm UltraEdge Operating Scissors, 14.5 cm, Sharp/Blunt, Straight Universal Clothing Scissors Friedman Bone Rongeurs, Delicate Scalpel Blades No. 11, Sterile Vannas Eye Scissors, Spring Action Model Tübingen, 8.5 cm, Straight* TC Olsen-Hegar Needle Holders with Scissors with Tungsten Carbide Inserts, 14.0 cm Jeweler’s Forceps, 11.0 cm, No. 5, with Extra Delicate Points Product Deluxe Major Surgical Kit Scalpel Handle, No. 3 Scalpel Blades No. 10, Sterile Eye Scissors, 11.5 cm, Curved, Special Cut Eye Scissors, 11.5 cm, Curved, Probe, 14.5 cm, Double Ended, 1 mm Diameter Product Minor Surgical Kit Scalpel Handle, No. 3 Scalpel Blades No. 10, Sterile Blumenthal Bone Rongeurs, Curved, 15.5 cm Blumenthal Bone Rongeurs, Jeweler’s Forceps, No. 5, 11 cm, with Extra Delicate Points Universal Clothing Scissors Operating Scissors, 14.5 cm, Kuehne Cover Glass Forceps, 10 cm, Angled Sharp/Blunt, Straight

To order call The Tübingen model has a longer blade than the standard Vannas scissors. ST1 72-8919 ST1 72-8912 ST1 72-8547 ST1 72-8905 ST1 72-8440 ST1 72-8598 ST1 72-8394 ST1 72-8450 ST1 72-8899 ST1 72-8362 ST1 72-8508 ST1 72-8696 # Order ST1 72-8941 Kit Components: ST1 72-8350 ST1 72-8360 ST1 72-8441 ST1 72-8912 # Order ST1 72-8940 Kit Components: ST1 72-8350 ST1 72-8360 ST1 72-8906 ST1 72-8696 ST1 72-8676 ST1 72-8393 ST1 72-8450 *Note:  Kit Major Surgical Deluxe This deluxe kit is ideally suited for more extensive procedures and major laboratory animal surgeries. This kit is ideally suited for basic procedures and suited for basic This kit is ideally minor surgery. Kit Minor Surgical SURGICAL KITS KITS SURGICAL

SURGICAL

INSTRUMENTS 6 45° Angle Blumenthal BoneRongeurs Curved Blumenthal BoneRongeurs Curved Friedman BoneRongeurs Straight Liston BoneCuttingForceps ST1 72-8907 Order # ST1 72-8906 Order # ST1 72-8905 ST1 72-8904 Order # ST1 72-8910 ST1 72-8909 ST1 72-8908 Order # To order call

1-508-893-8999 3.0 mm Length Jaw 4.0 mm Length Jaw 2.0 mm 3.0 mm Length Jaw 19.0 cm 17.0 cm 14.0 cm Length Overall

Length Overall Length Overall 14.0 cm 13.5 cm Length Overall 15.0 cm 14.5 cm Delicate Key Feature email

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SURGICAL 7 INSTRUMENTS www.harvardapparatus.com web [email protected] email

Overall Length 12.5 cm

Tan Green Green Blue Blue Color Color Overall Length 7.5 cm 10.0 cm 13.0 cm 3.0 mm 5.0 mm 5.0 mm 3.0 mm Tip Thickness 0.3 mm 3.0 mm Depth Depth 1-508-893-8999 45° 15° 15° 15° Tip Width 2.0 mm 15° Blade Angle Blade Angle Cutting Edge 1.5 mm Diameter 5.0 mm 5.0 mm 5.0 mm To order call Use with Chuck Handles, see above. Use with Chuck Handles, see above. Use with Mini-Blade®, see below. Use with Mini-Blade®, see ST1 56-5624 ST1 56-5657 # Order ST1 56-5762 ST1 56-5673 ST1 52-2664 # Order ST1 56-5754 # Order # Order ST1 56-5465 # Order ST1 56-5671 ST1 56-5655 ST1 56-5630 Dissecting Micro Wecker of 1 pkg. Spatula, Scalpels Disposable Micro of 6 pkg. with Handle, *Note:  Scalpels Disposable Micro of 6 pkg. without Handle, *Note:  of 24 pkg. Blade, Miniature of 1 pkg. *Note:  Chuck Handles, Knurled Round SCALPELS, KNIVES & HOOKS & KNIVES SCALPELS,

SURGICAL

INSTRUMENTS 8 pkg. of1 Ziegler Micro Dissecting Knife, pkg. of1 Graefe Micro Dissecting Knife, Hook AngularSharp, pkg. 1 Nugent Micro Dissecting pkg. Frazier Micro Dissecting Hook, Bowman Knife, pkg. of1 ST1 60-3978 ST1 60-3976 ST1 60-3975 Order # ST1 60-3980 ST1 60-3979 Order # ST1 52-2722 Order # ST1 52-2714 ST1 52-2706 Order # ST1 52-2730 Order # To order call of 1 1-508-893-8999 7.0 mm 5.0 mm 3.0 mm Edge Cutting 27.0 25.0 mm Edge Cutting 12.5 cm Length Overall 2.0 mm 2.0 mm Diameter Loop 3.0 mm Length Blade mm 11.0 cm 11.0 cm 11.0 cm Length Overall 12.0 cm 12.0 cm Length Overall Angular, Sharp Key Feature 12.0 cm Length Overall 12.5 cm 12.5 cm Length Overall No. 3 No. 1 No. 0 Key Feature No. 2 No. 1 Key Feature Spear Point Key Feature Blunt Sharp Key Feature email [email protected]

SCALPELS, KNIVES&HOOKS web www.harvardapparatus.com

SURGICAL 9 INSTRUMENTS www.harvardapparatus.com 15c web 15 13 12d 12 11 10 [email protected] email

pkg. of 10

1-508-893-8999

Overall Length 16.5 cm Overall Length 12.0 cm Product No. 10, Sterile, pkg. of 10 No. 11, Sterile, pkg. of 10 No. 12, Sterile, pkg. of 10 No. 13, Sterile, pkg. of 10 No. 15, Sterile, Product pkg. of 100 No. 10, Sterile, pkg. of 100 No. 11, Sterile, No. 12, Sterile, pkg. of 100 No. 12d, Sterile, pkg. of 100 No. 13, Sterile, pkg. of 100 No. 15, Sterile, pkg. of 100 No. 15c, Sterile, pkg. of 100 To order call # Order ST1 72-8354 # Order ST1 72-8350 # Order ST1 72-8370 ST1 72-8372 ST1 72-8373 ST1 72-8374 ST1 72-8375 # Order ST1 72-8360 ST1 72-8362 ST1 72-8364 ST1 75-0086 ST1 72-8366 ST1 72-8368 ST1 75-0087 7 Solid No. 3 Solid No. Scalpel Handle Scalpel Handle Disposable Scalpel Handle with Plastic Scalpel Blades Sterile 7 Handles 3 and No. use with No. for SCALPELS & BLADES & SCALPELS

SURGICAL

INSTRUMENTS 10 Scalpel BladeRemover No. 4Solid Plastic ScalpelHandle No. 4Solid Scalpel Handle for usewithNo. 4Handles Sterile ScalpelBlades ST1 810-199-00 Order # ST1 810-112-04 Order # ST1 72-8356 Order # ST1 75-0096 ST1 75-0095 ST1 75-0094 ST1 75-0093 ST1 75-0092 ST1 75-0091 ST1 75-0090 ST1 75-0089 ST1 75-0088 Order # To order call 1-508-893-8999 13.5 cm Length Overall No. 36,Sterile,pkg.of100 No. 25,Sterile,pkg.of100 No. 24, Sterile,pkg.of100 No. 23,Sterile,pkg.of100 No. 22Sterile,pkg.of100 No. 21,Sterile,pkg.of100 No. 20,Sterile,pkg.of100 No. 19,Sterile,pkg.of100 No. 18,Sterile,pkg.of100 Product 13.5 cm Length Overall

email [email protected] 18 19 20 21 22 23 web www.harvardapparatus.com 24 SCALPELS &BLADES 25 36

SURGICAL 11 INSTRUMENTS www.harvardapparatus.com web [email protected] email Angled Right Angled Left Feature Key

10.0 cm Overall Length

8.5 cm 8.5 cm 10.5 cm 12.0 cm Overall Length 10.5 cm Overall Length 10.0 cm Overall Length Overall Length

0.8 mm Tip Width 0.6 mm 0.5 mm 1.4 mm 0.6 mm Tip Width 1.4 mm Tip Width 1.4 mm Tip Width Tip Width 1-508-893-8999 9.0 mm 6.0 mm 11.0 mm 8.0 mm Cutting Edge 11.0 mm Cutting Edge 13.0 mm Cutting Edge 13.0 mm Cutting Edge Cutting Edge To order call ST1 72-8483 ST1 72-8503 ST1 72-8497 ST1 72-0143 # Order # Order ST1 72-8496 # Order ST1 72-8494 # Order ST1 72-8493 # Order Spring Scissors Vannas Sharp/Sharp Straight, Sharp/Sharp Straight, Spring Scissors Vannas Handles with Round Spring Scissors Castroviejo Angled, Sharp/Sharp Scissors Spring Castroviejo Sharp/Sharp Curved, Blunt/Blunt Curved, Spring Scissors Castroviejo SCISSORS

SURGICAL

INSTRUMENTS 12 the standardVannasscissors. Note: TheTübingenmodelhasalonger bladethan Curved, Sharp/Sharp Vannas TübingenSpringScissors the standardVannasscissors. Note: TheTübingenmodelhasalongerbladethan Straight, Sharp/Sharp Vannas TübingenSpringScissors Angled, Sharp/Sharp Vannas SpringScissors Curved, Sharp/Sharp Vannas SpringScissors Curved, Sharp/Sharp with Round Handles Vannas SpringScissors ST1 72-8509 Order # ST1 72-8508 Order # ST1 72-8507 ST1 72-8506 ST1 72-8505 ST1 72-8485 Order # ST1 72-8504 ST1 72-8484 Order # ST1 72-0144 Order # To order call 1-508-893-8999 8.0 mm Edge Cutting 10.0 mm Edge Cutting 5.0 mm 4.0 mm 7.0 mm 4.0 mm Edge Cutting 6.0 mm 3.0 mm Edge Cutting 8.0 mm Edge Cutting 0.6 mm Width Tip 0.7 mm Width Tip 0.7 mm 0.5 mm 0.4 mm 0.4 mm Width Tip 0.6 mm 0.4 mm Width Tip 0.6 mm Width Tip

8.0 cm Length Overall 8.5 cm Length Overall 12.5 cm 8.0 cm 8.0 cm 8.0 cm Length Overall 8.0 cm 8.0 cm Length Overall 12.0 cm Length Overall email [email protected] web www.harvardapparatus.com SCISSORS

13 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected]

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10.0 cm 5.5 cm 10.0 cm Overall Length Overall Length 8.0 cm 8.0 cm Overall Length Overall Length 0.5 mm 0.5 mm 0.5 mm Tip Width Tip Width 0.4 mm 0.4 mm Tip Width Tip Width 1-508-893-8999 5.0 mm 4.0 mm 5.0 mm Cutting Edge Cutting Edge 8.0 mm 8.0 mm Cutting Edge Cutting Edge To order call ST1 72-8515 ST1 72-8512 ST1 72-8514 # Order # Order ST1 72-8510 ST1 72-8511 # Order # Order Spring Scissors Barraquer Angled, Blunt/Blunt Angled, Blunt/Blunt Spring Scissors Troutman Note: The Tübingen model has a longer blade than the standard Vannas scissors. Sharp/Sharp Angled Up, Tübingen Spring Scissors Vannas Sharp/Sharp Side, to Angled has a longer blade thanNote: The Tübingen model the standard Vannas scissors. Scissors Spring Tübingen Vannas SCISSORS

SURGICAL

INSTRUMENTS 14 Straight, Sharp/Sharp Eye Scissors Straight, Sharp/Sharp Tungsten-Carbide Eye Scissors Straight, Sharp/Sharp Eye Scissors Curved, Sharp/Sharp Eye Scissors ST1 72-8438 Order # ST1 72-8430 ST1 75-0080 ST1 72-8428 ST1 72-8426 Order # ST1 72-8480 Order # ST1 72-8436 ST1 75-0081 ST1 72-8434 ST1 72-8432 Order # To order call 1-508-893-8999 28.0 mm Length Blade 32.0 mm 27.0 mm 27.0 mm 24.0 mm Length Blade 24.0 mm Length Blade 32.0 mm 26.0 mm 26.0 mm 25.0 mm Length Blade

11.5 cm Length Overall 12.5 cm 11.5 cm 11.5 cm 10.5 cm Length Overall 11.5 cm Length Overall 12.5 cm 11.5 cm 11.5 cm 10.5 cm Length Overall Delicate Key Feature Left Handed Key Feature Left Handed Key Feature email [email protected] web www.harvardapparatus.com SCISSORS

15 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected] email

Overall Length 9.0 cm Overall Length 11.5 cm Overall Length 11.5 cm Overall Length 11.5 cm 1-508-893-8999

Blade Length 15.0 mm 24.0 mm 24.0 Blade Length Blade Length 27.0 mm 27.0 mm 24.0 Blade Length To order call ST1 72-8442 # Order ST1 72-8441 # Order # Order ST1 72-8437 ST1 72-8440 # Order Scissors Fine Bonn Eye Extra Sharp/Sharp Straight, Note: Our Special Cut Scissors are especially durable and delicate, signified by a black handle. Scissors Special Cut Eye Sharp/Sharp Curved, Note: Our Special Cut Scissors are especially durable and delicate, signified by a black handle. Scissors Special Cut Eye Sharp/Sharp Straight, Scissors Eye Sharp/Sharp Angled, SCISSORS

SURGICAL

INSTRUMENTS 16 Curved, Sharp/Sharp Extra FineBonnEye Scissors Straight, Blunt/Blunt Dissecting Scissors Tungsten CarbideMetzenbaum Curved, Sharp/Sharp Operating Scissors Straight, Sharp/Sharp Tungsten CarbideOperating Scissors Straight, Sharp/Sharp Operating Scissors ST1 72-8443 Order # ST1 72-8481 Order # ST1 72-8424 ST1 72-8422 Order # ST1 72-8453 Order # ST1 72-8405 ST1 72-8403 ST1 72-8402 ST1 72-8400 Order # To order call 1-508-893-8999 14.0 mm Length Blade 29.0 mm Length Blade 55.0 mm 48.0 mm Length Blade 47.0 mm Length Blade 55.0 mm 49.0 mm 44.0 mm 32.0 mm Length Blade 9.0 cm Length Overall 14.0 cm Length Overall 16.0 cm 14.5 cm Length Overall 14.0 cm Length Overall 16.5 cm 14.5 cm 13.0 cm 10.5 cm Length Overall

email

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17 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected] email

Left Handed Left Handed Feature Key

Overall Length 10.5 cm 12.0 cm 14.0 cm Overall Length 14.5 cm 17.5 cm 17.5 cm 14.5 cm 14.5 cm Overall Length 1-508-893-8999 Blade Length 32.0 mm 32.0 mm 42.0 46.0 mm 48.0 mm Blade Length 51.0 mm 51.0 mm 51.0 41.0 mm 41.0 mm 41.0 Blade Length To order call # Order ST1 72-8379 ST1 72-8380 ST1 72-8384 ST1 72-8383 # Order ST1 72-8464 ST1 72-8463 ST1 72-8462 ST1 72-8461 # Order Scissors Operating Blunt/Blunt Straight, Carbide Mayo Tungsten Blunt/Blunt Straight, Scissors Operating UltraEdge Scissors Operating SCISSORS Blunt/Blunt Straight,

SURGICAL

INSTRUMENTS 18 Curved, Blunt/Blunt Operating Scissors Tungsten CarbideMayo Curved, Blunt/Blunt Operating Scissors Straight, Blunt/Blunt Tungsten CarbideOperating Scissors Straight, Sharp/Blunt Operating Scissors ST1 72-8469 ST1 72-8468 ST1 72-8467 ST1 72-8466 Order # ST1 72-8411 ST1 72-8409 Order # ST1 72-8456 Order # ST1 72-8395 ST1 72-8393 ST1 72-8392 ST1 72-8390 Order # To order call 1-508-893-8999 52.0 mm 52.0 mm 41.0 mm 41.0 mm Length Blade 54.0 mm 47.0 mm Length Blade 47.0 mm Length Blade 52.0 mm 47.0 mm 43.0 mm 33.0 mm Length Blade 17.0 cm 17.0 cm 14.5 cm 14.5 cm Length Overall 16.5 cm 14.5 cm Length Overall 14.0 cm Length Overall 15.5 cm 14.0 cm 13.0 cm 10.5 cm Length Overall

Left Handed Left Handed Key Feature

email [email protected] web www.harvardapparatus.com SCISSORS

19 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected] email

Overall Length 14.5 cm 16.5 cm Overall Length 17.0 cm Overall Length 14.5 cm 1-508-893-8999 Blade Length 45.0 mm 45.0 mm 51.0 Overall Length 14.0 cm 18.0 cm Blade Length mm 42.0 49.0 mm 49.0 Blade Length To order call # Order ST1 72-8415 ST1 72-8417 ST1 72-8450 ST1 72-8451 # Order ST1 72-8448 # Order ST1 72-8394 # Order Sharp/Blunt Curved, Scissors Operating Clothing Scissors Universal Angled, Blunt/Blunt Scissors Bandage Lister Angled, Blunt/Blunt Sharp/Blunt Straight, Scissors Operating UltraEdge SCISSORS

SURGICAL

INSTRUMENTS 20 Straight, Smooth with Round Handle Diamond Coated Micro Tweezer Straight, Smooth Tweezer withRound Handle Diamond Coated Titanium Micro Straight, Smooth Micro Tweezer with Round Handle Straight, 1x2Teeth Micro Tweezer ST1 72-8725 ST1 72-8721 ST1 72-8717 Order # ST1 72-8726 ST1 72-8722 ST1 72-8719 ST1 72-8718 Order # ST1 72-8720 Order # ST1 72-8715 Order # To order call 1-508-893-8999 1.0 mm 1.0 mm 1.0 mm Width Tip 1.0 mm 2.0 mm 1.0 mm 1.0 mm Width Tip 1.0 mm Width Tip 0.5 mm Width Tip

0.5 mm 0.2 mm 0.5 mm Dia. Ring 0.5 mm 0.1 mm 0.5 mm 0.5 mm Dia. Ring 2.0 mm Dia. Ring 8.5 cm Length Overall

15.0 cm 15.0 cm 15.0 cm Length Overall 18.0 cm 15.0 cm 15.0 cm 15.0 cm Length Overall 15.0 Length Overall Suture Platform Key Feature cm email

& Ring Suture Platform & Ring Suture Platform & Ring Suture Platform Key Feature & Ring Suture Platform & Ring Suture Platform & Ring Suture Platform & Ring Suture Platform Key Feature & Ring Suture Platform Key Feature [email protected]

web www.harvardapparatus.com TWEEZERS

21 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected] email

Suture Platform Extra Delicate Suture Platform Feature Key Extra Delicate Feature Key No Finish Lightweight Feature Key Feature Key

12.0 cm 15.0 cm 12.0 cm Overall Length 12.0 cm Overall Length 12.0 cm Overall Length 11.5 cm 12.0 cm 12.0 cm Overall Length Overall Length 1-508-893-8999

0.9 mm 1.3 mm 1.0 mm Tip Width 0.7 mm Tip Width 0.8 mm Tip Width 1.0 mm 0.1 mm 0.1 mm Tip Width Tip Width To order call ST1 72-8573 # Order ST1 72-8558 ST1 72-8575 # Order ST1 72-8556 # Order ST1 72-8557 ST1 72-8555 ST1 72-8548 # Order ST1 72-8547 # Order Forceps Tissue Adson 1 x 2 Teeth Straight, Fine Micro-Adson-Biemer Extra Forceps Tissue Micro-Adson 1 x 2 Teeth Straight, Angled, 1 x 2 Teeth Forceps Tissue 1 x 2 Teeth Straight, Forceps Tissue Micro-Adson Forceps Tissue Adson FORCEPS 1 x 2 Teeth Straight,

SURGICAL

INSTRUMENTS 22 *Note:  Straight, Serrated Graefe IrisForceps Straight, 1x2Teeth with Round Handles Titanium GilliesTissue Forceps Straight, Serrated Tissue Forceps Titanium DeBakey Atraumatic Straight, 2x3Teeth Adson Tissue Forceps ST1 72-8593* ST1 72-8591 ST1 72-8590 Order # ST1 72-8773 Order # ST1 72-8792 ST1 72-8791 ST1 72-8790 ST1 72-8789 ST1 72-8788 ST1 72-8787 ST1 72-8786 ST1 72-8785 ST1 72-8784 ST1 72-8783 ST1 72-8782 Order # ST1 72-8577 Order # To order call Stainless Steel#1.4301 These Non-Magnetic ForcepsaremadeofGerman 1-508-893-8999 1.0 mm 1.0 mm 0.7 mm Width Tip 1.6 mm Width Tip 2.0 mm 1.9 mm 1.8 mm 1.9 mm 1.8 mm 1.6 mm 1.6 mm 1.6 mm 1.0 mm 1.0 mm 1.0 mm Width Tip 2.2 mm Width Tip

10.0 cm 10.0 cm 10.0 cm Length Overall 15.0 cm Length Overall 20.0 cm 15.0 cm 24.5 cm 20.0 cm 15.0 cm 24.5 cm 20.0 cm 15.0 cm 24.0 cm 20.0 cm 15.0 cm Length Overall 12.0 cm Length Overall

Non-Magnetic Suture Platform Key Feature Light Weight Key Feature email [email protected]

web www.harvardapparatus.com FORCEPS

23 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected] email

Suture Platform Slightly Curved Suture Platform Suture Platform Feature Key

9.5 cm 9.5 cm 7.0 cm 9.5 cm 7.0 cm 7.0 cm 7.0 cm 9.5 cm Overall Length 8.5 cm Overall Length Overall Length 11.5 cm Overall Length 8.5 cm 1-508-893-8999

0.7 mm 0.8 mm 0.5 mm 0.5 mm 0.5 mm 0.7 mm 1.0 mm 0.4 mm Tip Width Tip Width 1.3 mm Tip Width 1.0 mm 1.3 mm Tip Width To order call ST1 72-8605 ST1 72-8604 ST1 72-8603 ST1 72-8602 ST1 72-8599 ST1 72-8600 ST1 72-8601 ST1 72-8598 # Order ST1 72-8650 # Order # Order ST1 72-8595 ST1 72-8649 # Order Serrated Curved, Iris Forceps Graefe Bishop-Harmon Iris Forceps 1 x 2 Teeth Straight, Serrated Straight, Bishop-Harmon Iris Forceps Iris Forceps Serrated Straight, FORCEPS

SURGICAL

INSTRUMENTS 24 Angled, Smooth Very Delicate Grasping Tips Nevyas Capsulorhexis Forceps with Curved, 1x2Teeth Gill IrisForceps Curved, Serrated Gill IrisForceps Strongly Curved, Serrated Graefe IrisForceps ST1 72-8658 Order # ST1 72-8654 Order # ST1 72-8653 Order # ST1 72-8615 ST1 72-8614 ST1 72-8612 ST1 72-8611 Order # To order call 1-508-893-8999 0.3 mm Width Tip 0.5 mm Width Tip 0.7 mm Width Tip 0.5 mm 0.4 mm 0.7 mm 0.5 mm Width Tip

10.0 cm Length Overall 7.5 cm Length Overall 7.5 cm Length Overall 19.5 cm 9.5 cm 7.0 cm 7.0 cm Length Overall

Long Shanks Key Feature Suture Platform Key Feature email

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25 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected] email

Suture Platform Suture Platform Suture Platform Suture Platform Feature Key Suture Platform Feature Key 10.5 cm 10.0 cm 9.5 cm 10.5 cm Overall Length 10.0 cm 10.0 cm Overall Length 11.0 cm 10.0 cm Overall Length 7.5 cm Overall Length 1-508-893-8999

1.0 mm 1.0 mm 0.5 mm 0.8 mm Tip Width 5.7 mm 0.6 mm Tip Width 0.5 mm 0.5 mm Tip Width 0.7 mm Tip Width To order call ST1 72-8671 ST1 72-8670 ST1 72-8676 ST1 72-8665 ST1 72-8669 # Order ST1 72-8664 # Order ST1 72-8663 ST1 72-8662 # Order ST1 72-8660 # Order Forceps Glass Cover Kuehne Angled, Smooth Angled, 1 x 2 Teeth Forceps Suture Castroviejo 1 x 2 Teeth Straight, Forceps Suture Castroviejo 1 x 2 Teeth Double Angled, Forceps Suture Troutman FORCEPS

SURGICAL

INSTRUMENTS 26 Curved, Smooth with Extra Delicate Tips Jewelers Forceps Straight, Smooth Jewelers Forceps Stainless Steel#1.4301. *Note: TheseNon-MagneticForcepsaremadeofGerman Straight, Smooth with Extra Delicate Tips Jewelers Forceps ST1 72-8700 ST1 72-8698* ST1 72-8696 ST1 72-8694 ST1 72-8693 ST1 72-8692 ST1 72-8691 ST1 72-8690 ST1 72-8689 Order # ST1 72-8701 Order # ST1 72-8687 ST1 72-8684 ST1 72-8683* ST1 72-8682 ST1 72-8681 ST1 72-8680 ST1 72-8679* ST1 72-8678 Order # To order call 1-508-893-8999 0.5 mm 0.4 mm 0.5 mm 0.5 mm 0.3 mm 0.5 mm 0.3 mm 0.4 mm 0.5 mm Width Tip 0.5 mm Width Tip 0.6 mm 0.4 mm 0.4 mm 0.6 mm 0.6 mm 0.6 mm 0.5 mm 0.5 mm Width Tip

11.5 cm 10.5 cm 10.5 cm 10.5 cm 10.5 cm 11.0 cm 12.0 cm 10.5 cm 10.5 cm Length Overall 11.5 cm Length Overall 11.0 cm 10.5 cm 10.5 cm 10.5 cm 11.5 cm 12.0 cm 11.5 cm 11.5 cm Length Overall

No. 7 No. 5 No. 5 No. 4 No. 4 No. 4 No. 3 No. 2 No. 1 Style No. 7 Style No. 3c No. 5 No. 4 No. 4 No. 3 No. 2 No. 1 No. 1 Style

email Non-Magnetic 3 Holes Lightweight, Key Feature Non-Magnetic Non-Magnetic Key Feature [email protected] web www.harvardapparatus.com FORCEPS

27 SURGICAL INSTRUMENTS www.harvardapparatus.com web

[email protected] email Extra Delicate Tips Feature Key

No. 5 No. 1 No. 6 No. 7 No. 7 Style Style Style

10.5 cm 11.5 cm Overall Length 17.5 cm 11.0 cm Overall Length 17.5 cm 11.5 cm 11.0 cm Overall Length Overall Length Overall Length 1-508-893-8999

0.4 mm 0.4 mm Tip Width 1.2 mm 0.5 mm Tip Width 1.1 mm 1.0 mm 0.8 mm Tip Width Tip Width Tip Width To order call ST1 72-8688 ST1 72-0142 # Order ST1 72-8686 ST1 72-0141 # Order ST1 72-8699 # Order ST1 72-8714 ST1 72-8685 # Order # Order Forceps Dressing Gerald Serrated Straight, Serrated Curved, Forceps Dressing Gerald Angled, Smooth Forceps Jewelers Forceps Jewelers Smooth Curved, Forceps Jewelers Tips Delicate with Extra FORCEPS 1 x 2 Teeth Curved,

SURGICAL

INSTRUMENTS 28 Straight, Smooth Titanium Dressing Forceps Straight, Serrated Titanium Dressing Forceps Curved, Serrated Dressing Forceps Straight, Serrated Dressing Forceps ST1 72-8764 Order # ST1 72-8762 ST1 72-8763 ST1 72-8761 ST1 72-8760 Order # ST1 72-8948 ST1 72-8947 ST1 72-8946 ST1 72-8945 ST1 72-8952 ST1 72-8951 Order # ST1 72-8950 ST1 72-8949 Order # To order call 1-508-893-8999 1.8 mm Width Tip 3.7 mm 2.0 mm 3.5 mm 3.5 mm Width Tip 2.7 mm 3.5 mm 1.2 mm 2.3 mm 1.7 mm 1.3 mm Width Tip 2.2 mm 1.8 mm Width Tip

18.0 cm Length Overall 24.0 cm 18.0 cm 18.0 cm 14.0 cm Length Overall 14.0 cm 14.0 cm 12.5 cm 11.5 cm 10.0 cm 8.5 cm Length Overall 14.0 cm 13.0 cm Length Overall email

[email protected] web www.harvardapparatus.com FORCEPS

29 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected]

email

Suture Platform Suture Platform Suture Platform Suture Platform Suture Platform Feature Key Suture Platform and Handle Suture Platform Feature Key Suture Platform Suture Platform and Handle Feature Key Feature Key

18.0 cm 18.0 cm 15.0 cm 18.0 cm 15.0 cm Overall Length 18.0 cm 17.5 cm Overall Length 17.5 cm 12.0 cm Overall Length Overall Length 1-508-893-8999

0.5 mm 0.5 mm 0.5 mm 0.4 mm 0.5 mm Tip Width 0.7 mm 0.6 mm Tip Width 0.8 mm 0.4 mm Tip Width Tip Width To order call ST1 72-8771 ST1 72-8769 ST1 72-8770 ST1 72-0444 ST1 72-8768 # Order ST1 72-0441 ST1 72-0443 # Order ST1 72-0442 ST1 72-0445 # Order # Order Forceps Micro Titanium Handle with Round Smooth Curved, Forceps Micro Titanium Smooth Curved, Handle with Round Smooth Straight, Forceps Micro Smooth Straight, Forceps Micro FORCEPS

SURGICAL

INSTRUMENTS 30 Curved, Serrated Hartmann Hemostatic Forceps Curved, Smooth Hartmann Hemostatic Forceps Straight, Serrated Hartmann Hemostatic Forceps Straight, Smooth Hartmann Hemostatic Forceps ST1 72-8961 ST1 72-8960 Order # ST1 72-8962 ST1 72-8956 ST1 72-8955 Order # ST1 72-8958 ST1 72-8957 Order # ST1 72-8959 ST1 72-8954 ST1 72-8953 Order # To order call 1-508-893-8999 1.0 mm 2.2 mm Width Tip 1.5 mm 1.7 mm 1.5 mm Width Tip 0.7 mm 1.4 mm Width Tip 1.7 mm 1.4 mm 1.5 mm Width Tip

9.5 cm 9.5 cm Length Overall 10.0 cm 12.0 cm 10.0 cm Length Overall 10.0 cm 9.0 cm Length Overall 10.0 cm 12.5 cm 9.5 cm Length Overall Extra Fine Key Feature Extra Fine Key Feature email [email protected]

web HEMOSTATIC FORCEPS www.harvardapparatus.com

31 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected]

email Overall Length 10.0 cm 12.0 cm Overall Length 10.0 cm 12.0 cm Overall Length 11.5 cm Overall Length 9.5 cm 12.0 cm 1-508-893-8999

Tip Width 1.4 mm 1.2 mm Tip Width 1.6 mm 1.7 mm Tip Width 1.3 mm 1.0 mm 1.0 mm Tip Width To order call ST1 72-8966 ST1 72-8967 # Order ST1 72-8968 ST1 72-8969 # Order # Order ST1 72-8963 ST1 72-8964 ST1 72-8965 # Order Forceps Hemostatic Micro-Mosquito Serrated Curved, 1 x 2 Teeth Serrated, Straight, Forceps Hemostatic Micro-Mosquito Forceps Hemostatic Micro-Mosquito Serrated Straight, Right, Serrated Angled Forceps Hemostatic Micro-Mosquito HEMOSTATIC FORCEPS HEMOSTATIC

SURGICAL

INSTRUMENTS 32 Straight, Serrated, 1x2Teeth Hemostatic Forceps Halstead-Mosquito Straight, Serrated Hemostatic Forceps Halstead-Mosquito Straight, Smooth Hemostatic Forceps Halstead-Mosquito Curved, Serrated, 1x2Teeth Micro-Mosquito Hemostatic Forceps ST1 72-8983 ST1 72-8982 Order # ST1 72-8974 ST1 72-8973 Order # ST1 72-8980 ST1 72-8975 ST1 72-8972 Order # ST1 72-8971 ST1 72-8970 Order # To order call 1-508-893-8999 2.2 mm 1.8 mm Width Tip 0.8 mm 1.5 mm Width Tip 2.0 mm 1.4 mm 1.5 mm Width Tip 1.7 mm 1.7 mm Width Tip

14.0 cm 12.0 cm Length Overall 12.0 cm 12.0 cm Length Overall 12.0 cm 12.5 cm 12.5 cm Length Overall 12.5 cm 9.5 cm Length Overall

Extra Fine Key Feature email [email protected] web HEMOSTATIC FORCEPS www.harvardapparatus.com

33 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected] email

Overall Length 12.0 cm 14.0 cm Overall Length 12.5 cm 12 cm Overall Length 12.0 cm 12.0 cm 14.0 cm 1-508-893-8999

Tip Width 2.0 mm 2.0 mm Tip Width 1.6 mm 1.9 mm 1.5 mm 0.9 mm 1.4 mm Tip Width To order call ST1 72-8984 ST1 72-8985 # Order # Order ST1 72-8976 ST1 72-8977 ST1 72-8978 ST1 72-8979 ST1 72-8981 # Order Halstead-Mosquito 1 x 2 Teeth Serrated, Curved, Forceps Hemostatic Halstead-Mosquito Forceps Hemostatic Halstead-Mosquito Smooth Curved, Serrated Curved, HEMOSTATIC FORCEPS HEMOSTATIC Forceps Hemostatic

SURGICAL

INSTRUMENTS 34 Straight, Smooth with Round Handle Barraquer NeedleHolders Straight, Smooth Castroviejo NeedleHolders Curved, Smooth with Round Handle Micro NeedleHolders Straight, Smooth with Round Handle Micro NeedleHolders ST1 72-8872 Order # ST1 72-8866 Order # ST1 72-8865 Order # ST1 72-0146 ST1 72-0145 Order # To order call 1-508-893-8999 14.0 cm Length Overall 17.5 cm Length Overall 18.0 cm Length Overall 14.5 cm 14.0 cm Length Overall without Lock Key Feature without Lock Key Feature without Lock Key Feature with Lock with Lock Key Feature

email

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35 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected]

email

Feature Key Left Hand Feature Key Extra Delicate Jaw Extra Delicate Jaw 1-508-893-8999 Overall Length 13.0 cm 16.0 cm Overall Length 15.5 cm 18.0 cm Overall Length 12.0 cm 11.5 cm 12.0 cm Overall Length To order call ST1 72-8902 ST1 72-8903 # Order ST1 72-8897 ST1 75-0081 # Order # Order ST1 72-8826 ST1 72-8884 ST1 72-8885 # Order Serrated Straight, Derf Needle Holders Gillies Mini Needle Holders with Carbide Jaws and Tungsten Scissors Smooth Curved, Carbide Jaws with Tungsten Serrated Straight, Needle Holders De Bakey Holders with Derf Needle NEEDLE HOLDERS NEEDLE Jaws Carbide Tungsten Smooth Straight,

SURGICAL

INSTRUMENTS 36 Straight, Serrated with Scissors Olsen-Hegar NeedleHolders Straight, Serrated Mayo-Hegar NeedleHolders Straight, Serrated Crile-Wood NeedleHolders Straight, Smooth Webster NeedleHolders ST1 72-8848 ST1 72-8847 ST1 72-8846 ST1 72-8845 ST1 72-8844 Order # ST1 72-8836 ST1 72-8835 ST1 72-8834 Order # ST1 72-8832 ST1 72-8831 ST1 72-8830 Order # ST1 72-8828 Order # To order call 1-508-893-8999 18.0 cm 18.5 cm 14.0 cm 11.5 cm 11.0 cm Length Overall 18.5 cm 16.0 cm 14.0 cm Length Overall 20.5 cm 18.0 cm 15.0 cm Length Overall 13.0 cm Length Overall

Extra DelicateJaw Key Feature email

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email

Feature Key with Lock with Lock and Groove with Lock with Lock Feature Key without Lock 1-508-893-8999 Overall Length 15.0 cm 14.0 cm 14.0 cm 16.5 cm 19.5 cm Overall Length Overall Length 13.0 cm Overall Length 12.0 cm 13.5 cm 16.0 cm To order call ST1 72-8850 # Order ST1 72-8851 ST1 72-8854 ST1 72-8857 ST1 72-8858 # Order ST1 72-8879 # Order # Order ST1 72-8898 ST1 72-8899 ST1 72-8900 Crile Needle Holders Serrated Straight, Serrated Straight, Needle Holders Mathieu Needle Holders Castroviejo Handle with Round Smooth Straight, with Needle Holders Olsen-Hegar NEEDLE HOLDERS NEEDLE Carbide Jaws and Tungsten Scissors Serrated Straight,

SURGICAL

INSTRUMENTS 38 Polyviolene® andLook® areregisteredtrademarksofAngiotech. *Note: Non-Sterilesuturespoolsare the specifiedlengthandsuppliedasanindividualspool. suture thatperformsexactlythewayyouexpectitto! considered amongthetightestinindustry.Theendresultisa U.S.P. standards.Indeed,LOOK®toleranceshavelongbeen Rigid inspectionsmakecertainsuturesmeetorexceedexacting aspect oftheproductioncycleandholdittohigheststandards. material totheshippingoffinishedproducts,theyoverseeevery control overthequalityofallproducts.Fromreceiptraw proprietary in-housemanufacturingprocessesgivethemmaximum LOOK® suturesandneedlesarethehighestqualityavailable.Their 2 1 0 2-0 3-0 4-0 5-0 6-0 Polyviolene GreenBrd. Nylon BlackMono. Nylon BlackBrd. Silk BlackBrd. Silk BlackBrd. Non-Sterile Spool* Size U.S.P. Suture Diameter Equivalents To order call

6 5 4 3.5 3 2 1.5 1.0 Catgut Natural European Pharmacopeia 1-508-893-8999 5 4 3.5 3 2 1.5 1.0 0.7 Materials Non-Absorbable Look® Sutures 91.4 m 91.4 m 91.4 m 91.4 m 22.9 m Length Suture – – – ST1 72-3288 ST1 72-3287 6-0 U.S.P. Size 0.50 mm 0.40 mm 0.35 mm 0.30 mm 0.20 mm 0.15 mm 0.10 mm 0.07 mm Minimum Suture Diameter LOOK email • • • [email protected] identify markings with easyto Superior packaging Sutures staysecure smoothly Needles penetrate ® Sutures ST1 51-7896 ST1 51-7821 ST1 51-7763 ST1 51-7680 ST1 51-7607 5-0 0.599 mm 0.499 mm 0.399 mm 0.339 mm 0.249 mm 0.199 mm 0.149 mm 0.099 mm Maximum Suture Diameter – ST1 51-7839 ST1 51-7771 ST1 51-7698 ST1 51-7615 4-0 ST1 51-7912 ST1 51-7847 – ST1 51-7706 ST1 51-7623 3-0 ST1 51-7920 ST1 51-7854 – ST1 51-7714 ST1 51-7631 2-0 web Polyviolene security withoutexcesscapillarity. processed foroptimumhandlingandknot Surgical blackbraidedsilkisspecially Silk BlackBraided preventing tissueingrowth. tissue, whilereducingtissuetrauma,and tensile strengthandeaseofpassagethrough smooth andnonporous,resultinginexcellent This blackandclearnylonmonofilamentis Nylon Monofilament the tissuewhileprolongingabsorption. treatment tomaintaintensilestrengthwithin characteristics asourplaingut,withspecial Chromic guthasthesamehighquality Gut Chromic-Absorbable polished toauniformdiameter. tensile strength.Allstrandsareprecision handling, dependableabsorption,andhigh quality rawmaterialtoensureeaseof Plain gutismanufacturedfromthehighest Gut Plain-Absorbable tissue trauma. offers auniformsurfacewhichminimizes and knot-tyingsecurity.Specialbraiding combination ofstrength,excellenthandling, polyester suturematerialhasaunique This greenandwhitebraidedPolyviolene® in greenandundyedversions. essentially completein50-90days.Available and reducedtissuetrauma.Absorptionis from itsproprietarycoating,lowfriction, that providesextraordinarysmoothness This materialisasyntheticabsorbablesuture Polyglycolic Acid Absorbable www.harvardapparatus.com SUTURES &NEEDLES – ST1 51-7862 – ST1 51-7722 – 0 ® Polyester ST1 51-7946 ST1 51-7870 – ST1 51-7730 – 1 ST1 51-7953 – – 2

39 SURGICAL INSTRUMENTS 2-0 – ST1 72-3331 – – ST1 72-3332 – – – – – ST1 72-3325 ST1 72-3314 – – – – 4-0 3-0 – ST1 72-3330 – – – – – Cutting Needles Reverse on Outer Curve. Cutting Edge difficult-to-penetrate For tough, tissues. Needles Cut Taper body. Cutting tip and taper two For tough tissues. Like needles in one. Needles Straight Cutting Smooth penetration for passage through tissues. www.harvardapparatus.com ST1 72-3317 ST1 72-3318 ST1 72-3322 – ST1 72-3313 ST1 72-3311 – – – 5-0 web 4-0 ST1 72-3328 ST1 72-3329 – – – – – 5-0 ST1 72-3327 – – – – – – – – – – ST1 72-3312 – ST1 72-3308 ST1 72-3306 ST1 59-6860 6-0 6-0 ST1 72-3326 Size U.S.P. – – – – – – – – – – – – – ST1 72-3305 – Size U.S.P. 7-0 Suture Length cm (18 in) 45 45 cm (18 in) 45 – – 45 cm (18 in) 45 – – PC33 [email protected] email 45 cm (18 in) 45 cm (18 in) 45 cm (18 in) 45 45 cm (18 in) 45 45 cm (18 in) 45 20 cm (12 in) 30 cm (12 in) 45 cm (18 in) 45 45 cm (18 in) 45 Suture Length Needles Circle 8 ⁄ 3 of 12 pkg. Circle, of 12 pkg. Circle, 8 8 ⁄ ⁄ 3 3 PC31 Suture Material PolyGlycolic Undyed Brd. PolyGlycolic Undyed Brd. – – PolyGlycolic Undyed Brd. – – Silk Black Brd. Gut-Chromic Gut-Plain Nylon Clear Mono. Nylon Black Mono. Nylon Black Mono. Gut-Chromic Nylon Black Mono. Silk Black Brd. Suture Material 1-508-893-8999 135° 15.1 mm 19 mm 135° 19.6 mm 24 mm 24 C3 13 mm 9.6 mm 158° 11 mm 9.0 mm 130° To order call Curvature Chord Length Length Curvature Chord Length Length Remarkably consistent and reliable Remarkably drag cleanly with minimal Penetrates breaking catching and Resists bending, Length Chord Length Curvature Length Chord Length Curvature C1 • • • C3 C1 Needles - Point Cutting Precision Reverse - Point Cutting Precision Reverse C3 PC31 Needles PC33 Needles Shown Actual Size. Cutting Reverse with Sutures These Harvard LOOK® Suture Needles are These Harvard LOOK® quality surgical manufactured from top designed to stay stainless steel and are passage sharp to ensure continued attached to the through tissue. They are technique providing suture by a swagging smooth strand one continuous, even, suture material. between the needle and to the right combination of hardness These needles are tempered hold their fine cutting edge/point and and tensile strength. They necessary pressure is applied. They provide resist bending when the Regular tests gauge a secure attachment for the suture material. needles sharpness and ductility. packaged in sterile, These Needles with Sutures are individually They are peelable, double envelopes for maximum protection. supplied in boxes of 12. Needles SUTURES & NEEDLES & SUTURES

SURGICAL

INSTRUMENTS 40 Sutures withReverse Cutting Needles ShownActualSize. Needles ShownActualSize. C7 Reverse Cutting- Needles C6 Needles Reverse CuttingPrecision Point - C7 C8 C10 C17 C22 To order call Length Chord Length Curvature Length Chord Length Curvature C6 C6 Length Curvature Chord Length Curvature Length Curvature Chord Length Chord Length Length Curvature Chord Length Length 1-508-893-8999 24 mm 19 mm 135° 18 mm 14.5 mm 135° 3 24 mm 135° 21 mm 135° 26 mm 135° 30 mm 12 mm 12 mm 135° 13 mm 16 mm ⁄ 8 Circle, pkg. of12 C7 C7 Gut-Chromic Gut-Plain Gut-Plain Silk BlackBrd. PolyGlycolic UndyedBrd. Nylon BlackMono. Nylon BlackMono. Gut-Chromic Gut-Plain Silk BlackBrd. Silk BlackBrd. Material Suture Material Suture Nylon BlackMono. Nylon BlackMono. Silk BlackBrd. PolyGlycolic UndyedBrd. Gut-Chromic Silk BlackBrd. Nylon BlackMono. Silk BlackBrd. Nylon ClearMono. Gut-Chromic Nylon BlackMono. Nylon BlackMono. Gut-Plain PolyGlycolic UndyedBrd. Nylon BlackMono. Polyviolene GreenBrd. 3 email ⁄ 8 Circle, pkg. of12 3 [email protected] ⁄ 8 Circle Needles(continued) C8 C8 70 cm(27 in) 70 cm(27 in) 45 cm(18in) 70 cm(27 in) 45 cm(18in) 25 cm(10in) 70 cm(27 in) 70 cm(27 in) 45 cm(18in) 75 cm(30in) Length Suture Length Suture 25 cm(10in) 45 cm(18in) 45 cm(18in) 70 cm(27 in) 70 cm(27 in) 45 cm(18in) 45 cm(18in) 45 cm(18in) 70 cm(27 in) 45 cm(18in) 45 cm(18in) 25 cm(10in) 25 cm(10in) 25 cm(10in) 45 cm(18in) 45 cm(18in) 45 cm(18in) – – – ST1 72-3336 ST1 51-0636 ST1 72-3334 ST1 51-0602 ST1 51-0578 ST1 51-0545 – 5-0 U.S.P. Size U.S.P. Size 6-0 – – – – – – – ST1 51-0461 – – ST1 51-0511 ST1 72-3350 – – ST1 51-6203 – – 5-0 – C10 – – – – – – ST1 51-0479 – ST1 51-6146 ST1 51-0529 ST1 72-3351 ST1 72-3353 ST1 72-3355 ST1 51-6211 C10 ST1 51-6237 ST1 72-3356

– – ST1 72-3341 ST1 72-3337 ST1 51-0644 – ST1 51-0610 ST1 51-0586 ST1 51-0552 – 4-0 web 4-0 ST1 72-3342 ST1 51-0776 – ST1 72-3344 – – – ST1 51-0487 – – ST1 51-0537 ST1 72-3352 ST1 72-3354 – – – – www.harvardapparatus.com SUTURES &NEEDLES C17 C17 – ST1 51-0743 ST1 51-0735 ST1 72-3338 ST1 51-0651 – ST1 51-0628 ST1 51-0594 ST1 51-0560 ST1 72-3333 3-0 3-0 – ST1 51-0784 – ST1 72-3345 – ST1 51-6674 – – ST1 72-3348 – – – – – – – – 2-0 – – ST1 51-6609 ST1 72-3346 – – ST1 51-6633 – – – – – – – – – – C22 C22 ST1 51-0768 ST1 51-0750 – – – – – – – – 2-0 0 – – – – ST1 51-6625 ST1 51-6690 – – – – – – – – – – –

41 SURGICAL INSTRUMENTS – – – ST1 72-3382 ST1 72-3387 1 1 – – – ST1 72-3367 – – – – – – C19 T10 www.harvardapparatus.com – – – ST1 72-3381 ST1 72-3386 0 C31 web 3-0 ST1 51-6955 ST1 72-3358 – – ST1 59-6867 – ST1 59-6863 ST1 59-6864 ST1 59-6861 ST1 59-6862 C14 T8 – ST1 72-3373 ST1 72-3375 – 2-0 C26 Size U.S.P. 4-0 – – – – – ST1 51-6930 – – – –

ST1 72-3371 ST1 72-3372 ST1 72-3374 – – Size U.S.P. 3-0 T9

C13 Suture Length 45 cm (18 in) 45 45 cm (18 in) 45 – 70 cm (27 in) cm (27 70 45 cm (18 in) 45 45 cm (18 in) 45 45 cm (18 in) 45 45 cm (18 in) 45 45 cm (18 in) 45 45 cm (18 in) 45 [email protected] 70 cm (27 in) cm (27 70 70 cm (27 in) cm (27 70 in) cm (27 70 in) cm (27 70 in) cm (27 70 in) cm (27 70 Suture Length email Needles Circle T 2 ⁄ C21 1 of 12 pkg. Circle, of 12 pkg. Circle, Needles Circle 2 2 2 ⁄ ⁄ 1 1 ⁄ 1 Gut-Chromic PolyGlycolic Green Brd. PolyGlycolic Green Brd. PolyGlycolic Green Brd. PolyGlycolic Green Brd. PolyGlycolic Green Brd. Suture Material Suture Material Silk Black Brd. Nylon Black Mono. PolyGlycolic Green Brd. – Silk Black Brd. Silk Black Brd. Silk Black Brd. Gut-Plain Silk Black Brd. Gut-Plain C12 T5 1-508-893-8999 180° 16.5 mm 23 mm 180° 29 mm 40 mm 180° 13 mm 18 mm 180° 13.5 mm 20 mm 180° 17.5 mm 26 mm 26 180° 16 mm 24 mm 24 13.1 mm 20.0 mm 18.5 mm mm 26.5 18.1 mm mm 26.0 mm 24.8 36.6 mm 29.4 mm 40.0 mm 180° 175° 170° 175° 160° C20 To order call Curvature Chord Length Length Curvature Chord Length Length Curvature Chord Length Length Curvature Chord Length Length Curvature Chord Length Length Curvature Chord Length Length Chord Length Length Chord Length Length Chord Length Length Chord Length Length Chord Length Length Curvature Curvature Curvature Curvature Curvature C9 T14 T5 T T8 T10 T14 - Point Cutting Precision Reverse - Point Cutting Precision Reverse Needles Needles C9 C14 C19 C20 C21 C31 Point Taper with Sutures Needles Shown Actual Size. Cutting with Reverse Sutures SUTURES & NEEDLES & SUTURES Needles Shown Actual Size.

SURGICAL

INSTRUMENTS 42 Eye Needles, Umbilical Tape Regular Surgeon’s, Product ST1 60-4179 ST1 60-4177 ST1 60-4175 ST1 60-4173 ST1 60-4171 Order # Umbilical Tape Umbilical Tape To order call ST1 60-4160 ST1 60-4159 ST1 60-4158 ST1 60-4157 Order # 1-508-893-8999 Size 20,pkg.of12 Size 18,pkg.of12 Size 16,pkg.of12 Size 14,pkg.of12 Size 12,pkg.of12 Product Size 4, pkg. of 12 Size 4,pkg.of12 Size 3,pkg.of12 Size 2,pkg.of12 Size 1,pkg.of12 Product Length 100 Yards 20 Yards 3 ⁄ Eye ofneedle=1mm 8 Eye ofneedle=2mm Circle, CuttingEdge ST1 72-3391 ST1 72-3388 1 3 ⁄ ⁄ 8 inch 8 4 2 3 1 Circle,CuttingEdge 20 14 16 18 12 email – ST1 72-3389 1 [email protected] ⁄ 4 inch – ST1 72-3390 3 ⁄ 8 inch Regular Surgeon’s, Eye Needles, Eye Needles, ST1 60-4164 ST1 60-4163 ST1 60-4162 ST1 60-4161 Order # ST1 60-4190 ST1 60-4188 ST1 60-4186 ST1 60-4184 ST1 60-4182 Order # ST1 60-4168 ST1 60-4167 ST1 60-4165 Order # Size 4,pkg.of12 Size 3,pkg.of12 Size 2,pkg.of12 Size 1,pkg.of12 Product Size 20,pkg.of12 Size 18,pkg.of12 Size 16,pkg.of12 Size 14,pkg.of12 Size 12,pkg.of12 Product Size 4,pkg.of12 Size 3,pkg.of12 Size 1,pkg.of12 Product web 1 1 ⁄ ⁄ 2 2 Circle, CuttingEdge Circle, Taper Point www.harvardapparatus.com SUTURES &NEEDLES Eye ofneedle=2mm Eye ofneedle=1mm 1 ⁄ 2 Circle, CuttingEdge 4 3 1 20 14 16 18 12 4 2 3 1

43 SURGICAL INSTRUMENTS

Ideal for temporary Ideal for temporary small clamping of animal vessels Stainless steel For temporary occlusion of flow through a vessel Stainless steel • • • • Clips Aneurysm Micro Clips Vascular Micro These stainless steel clips are available in three sizes. They www.harvardapparatus.com web Occlusion Pressure 35 to 40 g, 11 mm long Occlusion Pressure 35 Micro Vascular Clip for 2 to 3 mm Diameter Vessels, Occlusion Pressure 50 to 60 g, 14 mm long Applying Forcep for Vascular Clips, in) Long 12.1 cm (4.75 Product Micro Vascular Clip for 1 mm Diameter Vessels, g, 8 mm long Occlusion Pressure 30 to 35 Micro Vascular Clip for 1 to 2 mm Diameter Vessels, Product gm Pressure, 70 Micro Aneurysm Clip, Straight, 0.8 mm width, 5 mm long gm Pressure, Micro Aneurysm Clip, Straight, 70 mm width, 6 mm long 0.75 gm Pressure, Micro Aneurysm Clip, Slight Curve, 70 1 mm Width, 6 mm Long Micro Aneurysm Clip, Strong Curve, gm Pressure, 1 mm Width, 6 mm Long 70 Pressure, Angle, 85 gm Micro Aneurysm Clip, 45° 1 mm Width, 6 mm Long Applying Forcep for Micro Aneurysm Clips, 14 cm (5.5 in) Long Applying Forcep for Micro Aneurysm Clips with Lock, in) Long 14.6 cm (5.75 Clips and Forcep sold separately Clips and Forcep sold separately ST1 61-0197 ST1 61-0198 # Order ST1 61-0195 ST1 61-0196 # Order ST1 61-0186 ST1 61-0187 ST1 61-0188 ST1 61-0189 ST1 61-0190 ST1 61-0191 ST1 61-0192 These micro aneurysm clips provide an easy and secure way to stop to way secure and easy an provide clips aneurysm micro These of procedures on vessels. Using one blood flow while performing the listed below, simply grasp the clip to open the applying forceps the and release. To remove, just perform jaw, slide it over the vessel It’s that simple. They do not compromise the procedure in reverse. of 1. vessel integrity. Package Autoclip is a registered trademark of Mikron Precision, Inc. are easy to apply using ST1 61-0198 forcep listed below. are easy to apply using ST1 61-0198 Package of 1.

ST1 34-0556 [email protected] ST1 34-0554

email

Skin Closure ™ Small 7 or 9 mm Small 7 or clip size wound Innovative clip system • • Reflex System Clips are available in two sizes, 7 Clips are available in

™ CLIPS & CLAMPS 1-508-893-8999 Remover Forceps for both 7 mm and 9 mm clips Applier for 7 mm Clips Applier for 9 mm Clips Clips, 7 mm, Box of 100 Clips, 9 mm, Box of 100 ™ ™ ™ ™ ™ Reflex Reflex Reflex Reflex Product Applicator,Autoclip® Starter Set, Includes ST1 34-0554 Handy Plastic Case Autoclip® Applicator for 9 mm Clips Autoclips®, 9 mm, Stainless Steel, Pkg. of 100 Autoclip® Removal Forcep ST1 34-0556 Removal Forcep, 100 x 9 mm clips, in aST1 34-0556 Product Reflex System Closure Wound ® Skin Closure System is a fast and effective method to Skin Closure System To order call ™ wound clips. Applier, remover and clips make a complete wound clips. Applier,

™ In use for over 40 years Provides maximum holding force with minimal trauma Starter Set includes 9 mm wound clips, applicator, and removal forcep Automatic, spring-fed applicators permit rapid, unassisted application Skin ™ ST1 34-3748 • • • • ST1 34-0554 ST1 72-6061 ST1 72-6062 ST1 72-6063 ST1 72-6064 # Order ST1 34-0557 ST1 34-0554 ST1 52-3748 ST1 34-0556 # Order ST1 72-6060 Reflex Closure System set. Each sold separately. close wounds on animals. This system eliminates the need for suture This system eliminates the need for suture close wounds on animals. The Reflex material and a needle. mm and 9 mm. The remover forceps will work in conjunction with forceps will work in conjunction with mm and 9 mm. The remover all Reflex This Autoclip® wound closure system provides a rapid, easy to use method to securely close wounds. When the wound is healed, simply remove the clip using the handy removal forcep. A convenient starter set is offered for first time buyers which includes an Autoclip® applicator, Autoclips®, and removal forcep. The stainless steel Autoclips® are 9 mm in size. Instruments and wound clips are supplied non-sterile, but may be autoclaved. Autoclip ST1 34-0557 Autoclip® Starter Set The Reflex CLIPS, CLAMPSCLIPS, PROBES &

SURGICAL

INSTRUMENTS 44 Probes Double EndedProbes Straight Vessel Clips Diethrich MiniBulldogClamp Straight Dieffenbach Vessel Clips ST1 72-8917 ST1 72-8916 ST1 72-8915 Order # ST1 72-8914 ST1 72-8913 ST1 72-8912 ST1 72-8911 Order # ST1 72-8993 ST1 72-8816 Order # ST1 72-8817 Order # ST1 72-8815 Order # To order call 1-508-893-8999 2.0 mm 2.0 mm 2.0 mm Tips 1.0 mm 1.0 mm 1.0 mm 1.0 mm Tips Applying Forceps 0.75 mm Width Jaw 50.0 mm Length Overall 35.0 mm Length Overall

Length Overall Length Overall 4.0 mm Length Overall 50.0 g Pressure Clamp 14.0 cm 16.0 cm 16.0 cm 18.0 cm 18.0 cm 13.0 cm 14.5 cm 125.0 g Pressure Clamp email [email protected] CLIPS, CLAMPS &PROBES CLIPS, CLAMPS web www.harvardapparatus.com

45 SURGICAL INSTRUMENTS

www.harvardapparatus.com web

Product Long Jaw Clip, pkg. of 1 Product Pointed Jaw Clip, pkg. of 1 Extra Fine Pointed Jaw Clip, pkg. of 1 Product Long Flat Jaw Clip, pkg. of 1 Product pkg. of 1 Thread Connection Clip, Product Flat Serrated Hook Clip, pkg. of 1 # Order ST1 73-3340 # Order ST1 73-0574 ST1 73-3563 # Order ST1 73-0575 # Order ST1 73-0572 # Order ST1 73-0573 Clip Jaw Long This Long Jaw Clip has longer jaws. The jaw size is 0.7 x 5 mm. The Long Jaw Clip is constructed from stainless steel wire which is 0.5 mm in diameter. The overall length of the clip is 18 mm. Clip Jaw Pointed This clip features pointed jaws and side loops is for simple operation. The Pointed Jaw Clip is constructed from stainless steel wire which clip 0.5 mm in diameter. The overall length of the also is 14 mm. An Extra Fine Pointed Jaw Clip is wire available. It is constructed from stainless steel of the which is 0.4 mm in diameter. The overall length clip is 10 mm. Clip Jaw Flat Long This clip features long flat jaws and side loops for simple operation. The Long Flat Jaw Clip is constructed from stainless steel wire which is 0.5 mm in diameter. The overall length of the clip is 18 mm. The jaw size is 0.5 x 5 mm. Clip Connection Thread of the tension simple attachment This clip permits feature of the transducers. The special thread to the thread can easily is that the length of the thread clip or make a knot. without having to undo be adjusted and secure clamping even This clip provides reliable Thread Connection Clip is with fine threads. The steel wire which is 0.5 mm constructed from stainless mm. all length of the clip is 45 in diameter. The over Hook Clip Serrated Flat stainless steel hook jaws This clip has flat serrated Serrated Hook Clip is and side loops. The Flat is 0.5 mm constructed from stainless steel wire which 17 mm. in diameter. The overall length of the clip is

in) 4 ⁄ 1

7 mm ( Clip Speed Maximum 10 mm (0.4 in) [email protected] email in) For suspending For suspending preparations biological in tissue vessels Rapid sample attachment Even clamping pressure Lightweight; small size Extremely low drug absorption Easily cleaned 4 ⁄ 1 • • • • • • Apparatus Harvard These light, spring wire heart clips are used to attach a thread to a frog or mammalian heart. Both clips are made of stainless steel wire and ensure a firm grip. Heart Clips Apparatus Harvard Clips Tissue 16 mm (0.6 in) 32 mm (1 32 Clip Length

3.8 mm tions such as vascular smooth 1-508-893-8999 3.8 x 11.4 mm (0.150 x 0.450 in) 3.8 x 11.4 mm (0.150 x 0.450 No Slip at 40 g min Barex 210, Vistron Corp. Stainless Steel Tube 250 mg Not Actual Size Frog Heart Clips Mammalian Heart Clips Product Product Harvard Tissue Clips, pkg. of 2

To order call 11.4 mm 11.4 Clip Axle/Spring Not Actual Size ST1 50-5909 ST1 50-5917 # Order ST1 56-5119 # Order Clamping Pressure Materials: Weight Specifications Overall Size *Note: Supplied in package of 5. A pair of these tissue clips provides a quick and simple means A pair of these tissue of biological tissue for suspension in of attaching small pieces isolated tissue vessels. Prepara­ intestinal sections muscle, papillary muscle, skeletal muscle and clip. The clip provides are particularly well suited for this type of region by means of a firm uniform pressure across the clamping stainless steel spring. CLIPS & CLAMPS CLIPS

SURGICAL

INSTRUMENTS 46 constructed fromstainlesssteelwirewhichis0.3mmindiameter. cylindrical vesselsegmentsandtrachealrings.All3sizesare These TriangularHooksareusedtosupporttissueringsfor Triangular Hooks ST1 73-0578 Order # ST1 73-0577 Order # ST1 73-2258 ST1 73-2249 ST1 73-2257 Order # To order call ST1 73-2257 • • • Holder forvesselsegmentsupto8mm(0.3in)inlength Ideal forcylindricalvesselsegmentsandtrachealrings Three sizesavailablefortissuerings 1-508-893-8999 diameter. Theoveralllengthofthehookis7.5mm. from stainlesssteelwirewhichis0.5mmin permits easymountingoforgans.Itisconstructed The OrganHookCliphasapointedhookthat Organ Hook is 2mm. overall lengthoftheclipis16mm.Thejawdiameter to theST173-3340, butisfinerindimensions.The steel wirewhichis0.3mmindiameter.Itsimilar The LongLoopClipisconstructedfromstainless Long Loop Clip Organ Hook,pkg.of1 Product Long LoopClip,pkg.of1 Product Height 11.0mm,LoopØ3.0mm,pkg.of1 Triangular HookSize2,Width12.0mm, Height 9.0mm,LoopØ2.5pkg.of1 Triangular HookSize1,Width8.0mm, Height 5.4mm,LoopØ2.0pkg.of1 Triangular HookSize0,Width5.0mm, Product

email

[email protected] ST1 73-2258 ST1 73-2249 ST1 73-2257 length is8mm(0.3in). wire whichis0.3mmindiameter.Themaximumvesselsegment is requiredpervesselsegment.Itconstructedfromstainlesssteel This triangularholderisusedforholdingvesselsegments.Onepair Holder for Vessel Segments vessel segmentlengthis8mm(0.3in). stainless steelwirewhichis0.3mmindiameter.Themaximum to holdthetissueat90°fromtopholder.Itisconstructed pair isrequiredpervesselsegment.Thebottomtriangletwisted This triangularholderisusedforholdingvesselsegments.One Holder for Vessel Segments,Twisted 90° ST1 73-2259 ST1 73-3339 Order # ST1 73-3096 Order # ST1 73-2259 Order # ST1 73-3096 Serre FineTipClosingClip,pkg.of1 Product 1 pair Holder forVesselSegments,LowerTriangleTwistedby90°, Product Holder forVesselSegments,1pair Product web The overalllengthoftheclipis17mm. 0.5 mmindiameter.Thejawmeasures3mm. constructed fromstainlesssteelwirewhichis tip closingjawsforsecuringtissues.Itis This SerreFineTipClosingClipfeatures Serre FineTip ClosingClip www.harvardapparatus.com CLIPS &CLAMPS

47 SURGICAL INSTRUMENTS www.harvardapparatus.com web [email protected] email

Overall Length 16.0 cm 14.0 cm 14.0 cm 14.0 cm 1-508-893-8999

Tip Width 12.0 mm 14.0 mm 16.0 mm 18.0 mm Overall Length 9.5 cm Overall Length 6.5 cm Overall Length 3.0 cm 4.0 cm To order call ST1 72-8926 ST1 72-8927 ST1 72-8928 ST1 72-8929 # Order ST1 72-8925 # Order # Order ST1 72-8920 # Order ST1 72-8918 ST1 72-8919 Lid Retractors Desmarres Retractor Castroviejo Retractor Graefe (Colibri) Barraquer RETRACTORS Retractor

SURGICAL

INSTRUMENTS 48 INSTRUMENT CARE

CARE AND MAINTENANCE Protect your investment by taking care of your surgical instruments. Properly cleaning and maintaining your surgical tools is extremely important and far less costly than replacing instruments. Proper care and maintenance includes cleaning, lubricating, sterilizing, and storing your instruments. This will ensure SURGICAL longevity and optimum performance. INSTRUMENTS

Glass Bead Dry Sterilizer

• Quick and inexpensive way to sterilize surgical instruments • Glass bead bath maintains constant 233°C • Sterilize in 15 seconds • No messy chemicals or open flames in the laboratory

This compact unit provides a quick and easy way to sterilize surgical instruments. The stainless steel, central well is filled with dry glass beads that are heated to 233°C. Simply insert an instrument into the beads and, within 15 seconds, the submerged portion of the instrument is sterilized. It’s that easy! This unit is supplied ready to use. Replacement glass beads are available separately. This product is a must for any laboratory doing small animal surgery. It is recommended that you replace the beads every six months.

Specifications Warm Up Time 20 min Working Temperature 233°C Sterilization Time 15 sec Well Size, OD x D 51 x 102 mm (2 x 4 in) Dimensions, H x W x D 17.2 x 13.3 x 13.3 cm (6.75 x 5.25 x 5.25 in) Weight 2 kg (4.5 lbs)

Order # Product ST1 61-0183 Hot Bead Sterilizer, 120 VAC, 60 Hz ST1 61-0185 Replacement Glass Beads, 1.5 mm OD, 10 oz. Bag ST1 72-0120 Hot Bead Sterilizer, Ireland ST1 72-0121 Hot Bead Sterilizer, UK ST1 72-0122 Hot Bead Sterilizer, Australia & China ST1 72-0123 Hot Bead Sterilizer, Denmark ST1 72-0124 Hot Bead Sterilizer, Sweden ST1 72-0125 Hot Bead Sterilizer, Netherlands ST1 72-0126 Hot Bead Sterilizer, Belgium ST1 72-0127 Hot Bead Sterilizer, Germany ST1 72-0128 Hot Bead Sterilizer, Finland ST1 72-0129 Hot Bead Sterilizer, Luxembourg ST1 72-0130 Hot Bead Sterilizer, Austria ST1 72-0131 Hot Bead Sterilizer, France ST1 72-0132 Hot Bead Sterilizer, Spain ST1 72-0133 Hot Bead Sterilizer, Portugal ST1 72-0134 Hot Bead Sterilizer, Italy

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 49

www.harvardapparatus.com web Product Stainless Steel Sterilization Instrument Case, x 2.56 in) x 5.51 20 x 14 x 6.5 cm (7.87 sterility of instruments Ideal for sterilization of surgical instruments Silicone rubber inserts protect instruments Includes two racks with silicone rubber inserts maintain Includes two long-term textile filters to • • • • # Order ST1 75-0097 Case Instrument Sterilizing Steel Stainless duty stainless steel case This sterilization instrument case is a heavy The lid is hinged built to withstand even the harshest lab conditions. and can lock in place. silicone rubber inserts This case includes two removable racks with to protect your surgical instruments. It also contains two long- interior plates; one on term textile filters attached by removable These filters prevent the top and one to the bottom of the case. sterile while inside contamination thus keeping the instruments the case. This sterilization instrument case is suitable for autoclaving or gas sterilization of surgical instruments.

[email protected] email 1-508-893-8999 Product Plastic Sterilization Instrument Tray with Base, Lid and in) 1 Silicone Mat, 15.2 x 6.4 x 1.9 cm (6.0 x 2.5 x 0.75 Plastic Sterilization Instrument Tray with Base, Lid and in) 1 Silicone Mat, 16.5 x 10.2 x 1.9 cm (6.5 x 4.0 x 0.75 Plastic Sterilization Instrument Tray with Base, Lid, Insert and 2 Silicone Mats, 25.4 x 15.2 x 3.8 cm (10.0 x 6.0 x 1.5 in) Plastic Sterilization Instrument Tray with Base, Lid and in) 1 Silicone Mat, 38.1 x 25.4 x 1.9 cm (15.0 x 10.0 x 0.75 Plastic Sterilization Instrument Tray with Base, Lid, Insert and 2 Silicone Mats, 38.1 x 25.4 x 3.8 cm (15.0 x 10.0 x 1.5 in) To order call Ideal for sterilization of surgical instruments of instruments Includes silicone mat for safe placement all instruments Perforated, see through lid for visibility of • • • ST1 75-0105 ST1 75-0106 ST1 75-0107 ST1 75-0108 ST1 75-0109 # Order This sterilization instrument tray is made of medical grade plastic. This sterilization instrument tray is made of so all instruments are Perforated lid is removable and see through visible. different sizes and There are several different tray options available; at least one silicone mat different components, but all trays include for safe placement of instruments. for autoclaving or gas This sterilization instrument tray is suitable sterilization of surgical instruments. Trays Instrument Sterilizing Plastic INSTRUMENT CARE INSTRUMENT

SURGICAL

INSTRUMENTS 50 (1.25 in)deep. adjustable cushions.Availableintwosizes.Allsizesare32 mm from touchingeachother.Traysareavailablewithandwithout instruments, whileseparatingpinshelptokeeptheinstruments during thesterilizationprocess.Siliconerubberinsertsprotect effective waytoprotectyourexpensivesurgicalinstruments This stainlesssteelinstrumenttrayprovidesaconvenientand Micro Instrument Sterilizing Trays ST1 61-0218 ST1 61-0217 ST1 61-0216 ST1 61-0215 Order # To order call • • • • Removable cover Silicone rubberinsertsprotectinstruments Separating pinsprovideinstrumentstability microsurgical instruments Ideal forsterilizationofdelicateand 1-508-893-8999 20.3 x31.8cm(812.5in) Micro InstrumentSterilizingTraywithAdjustableCushions, Micro InstrumentSterilizingTray,20.3x31.8cm(812.5in) 20.3 x21.6cm(88.5in) Micro InstrumentSterilizingTraywithAdjustableCushions, Micro InstrumentSterilizingTray,20.3x21.6cm(88.5in) Product email [email protected]

cleaning, rinsing,sterilizingorlubricatingyourinstruments. tray withinadeepertocreatecloseddrainingcontainerfor for autoclavingorcoldchemicalsoaks.Useashallowperforated so theywillnotchiporbreaklikeglasstrays.Theycanbeused These heavy-dutytraysareconstructedof30418-8stainlesssteel Sterilizing/Instrument Trays ST1 61-0213 ST1 61-0207 ST1 61-0206 ST1 61-0205 ST1 61-0204 ST1 61-0203 ST1 61-0202 ST1 61-0211 ST1 61-0201 ST1 61-0200 ST1 61-0199 Order # • • • protecting instruments Excellent fororganizing,storingand lubricate instruments Can beusedtoclean,rinse,sterilizeand Ideal foruseinautoclaveorchemicalsoak (13.5 x9.75 in),1.9cm(0.75 in)deep Tray,solid,33.7x24.8Sterilizing/Instrument cm 31.1 x19.7cm(12.257.75 in) Tray, Lid forSterilizing/Instrument (12.25 x7.75 in),5.7cm(2.25in)deep Tray,perforated,31.1x19.7cm Sterilizing/Instrument (12.25 x7.75 in),5.7cm(2.25in)deep Tray,solid,31.1x19.7cm Sterilizing/Instrument 25.4 x16.5cm(106.5in) Tray, Lid forSterilizing/Instrument (10 x6.5in),5.1cm(2in)deep Tray,perforated,25.4x16.5cm Sterilizing/Instrument (10 x6.5in),5.1cm(2in)deep Tray,solid,25.4x16.5cm Sterilizing/Instrument (10 x6.5in),1.9cm(0.75 in)deep Tray,solid,25.4x16.5cm Sterilizing/Instrument Tray,22.9x12.7cm(95in) Lid forSterilizing/Instrument (9 x5in),5.1cm(2in)deep Tray,perforated,22.9x12.7cm Sterilizing/Instrument 5.1 cm(2in)deep Tray,solid,22.9x12.7cm(95in), Sterilizing/Instrument Product web www.harvardapparatus.com INSTRUMENT CARE

51 SURGICAL INSTRUMENTS www.harvardapparatus.com web Product Surgical Towels, pkg. of 12 Product cm (20 x 20 in) x 51 51 in) x 24 cm (24 x 61 61 cm (30 x 30 in) x 76 76 x 40 in) cm (40 x 102 102 • Autoclavable • Ideal for surgery • Highly absorbent # Order ST1 59-7435 # Order ST1 59-7430 ST1 59-7431 ST1 59-7432 ST1 59-7433 Wraps Instrument These Instrument Wraps are manufactured of double thick, pre- shrunk, colorfast, surgical sheeting and may be safely washed and autoclaved. Supplied as a single wrap. Towels Surgical towels are for use in These highly absorbent, 100% cotton, durable They are autoclavable surgery and measure 46 x 84 cm (18 x 33 in). and are supplied in a package of 12.

17.8 x 3.2 cm (7 x 1¼ in) – – ST1 59-7426

[email protected] email A must for every laboratory Concentrated cleaner that is pH neutral Instrument Milk recommended for all instruments with metal to metal action before autoclaving 10.2 x 1.9 cm x ¾ in) (4 ST1 59-7421 ST1 59-7423 ST1 59-7425 •  •  • 

Cleaner and Instrument Lubricant (Milk) Opening Size 5.1 x 2.5 cm (2 x 1 in) – ST1 59-7422* – 1-508-893-8999 Product Instrument Cleaner, 8 oz. Bottle Instrument Lubricant (Milk), 8 oz. Spray Bottle To order call Double central panel made from medical fabric that Double central panel from permeating through prevents outside contaminants • Autoclavable • Built-in moisture barrier •  # Order ST1 61-0221 ST1 61-0222 Size Overall 51 x 51 cm (20 x 20 in) cm (30 x 30 in) x 76 76 x 40 in) cm (40 x 102 102 INSTRUMENT CARE INSTRUMENT This Cleaner and Lubricant are the perfect companions for all of your surgical instruments. No laboratory should be without them. The Instrument Cleaner is a perfect cleaner for your surgical instruments. This phosphate free formula is ideal for manual or ultrasonic cleaning or soaking of surgical instrument. Supplied in an 8 ounce bottle. The Lubricant (Milk) is ideal for lubricating all moving parts. Supplied in an 8 ounce spray bottle for easy application. Steam compatible. These Drapes have a built-in moisture barrier. This double These Drapes have a built-in moisture barrier. that prevents outside central panel is made from a medical fabric drape to the work area. contaminants from permeating through the surgical sheeting They are manufactured of color fast, pre-shrunk, Supplied as a single and may be safely washed and autoclaved. drape or box of 12 as noted. Drapes Surgical

SURGICAL

INSTRUMENTS 52 gauze andmeasure12.7mm( is necessaryindelicateprocedures.Cherryspongesarealsoall microsurgery. These sterile,cellulosesponges are fortheremovaloffluidsduring sponges percase. sponges areavailablesterileornon-sterileandsupplied500 encompass theX-Rayelementandeliminatelooseedges.These are 9.5mm( resorbable. Suppliedintwosterile2.5g(0.09oz)packets. (tamponade) barrier.Itdoesnotactbiochemicallyandisminimally achieve localhemostasisofbonebyactingasamechanical agent, usedtohelpcontrolbleedingfrombonesurfaces.Itcan the reparativeprocess. fusion aredesired.Itmayinhibitosteogenesisandactasaphysicalbarrierto *Note: BoneWaxshouldnotbeusedwhererapidosseousregenerationand ST1 59-8433 ST1 59-8431 Order # ST1 59-9864 Order # ST1 59-8422 Order # To order call Bone Wax ST1 59-9864 Sponges Peanut 3 1-508-893-8999 ⁄ 8 Cherry Sponges,SterileStandardpkg.of5,500perCase Peanut Sponges,SterileStandardpkg.of5,500percase Product Bone Wax* Product Spear-Shaped Sponges, pkg.of200 Product in)indiameterandareusedwhenprecisesponging Cherry Sponges 1 ⁄ 2 in).Botharecarefullyfoldedto The allgauzepeanutsponges shapes. available inpeanutorcherry detectable element.Theyare and havealocked-inX-Ray They aredoublewrapped delicate surgicalprocedures. gauze spongesareforusein These small,firm,topquality Dissecting Sponges palmitate, awax-softening of beeswaxandisopropyl Bone Waxisasterilemixture Bone Wax Spear-Shaped Sponges email • • • • • • [email protected] 200 spongessupplied Disposable added flexibility plastic handlefor Integral, bendable convenient Economical and tip immersed Absorbs withonlythe in theskull to patchholesmade during surgeryand To stopbleeding

Instant Iceisaregistered trademarkofGebaurerCompany. spray ina3.5oz(103.5 ml)aerosolcan. bruising andcontusions.InstantIce®isavailableinamistorstream from musclespasms,minorpainandswellingsprains,strains, placing inacavityorclosedtissuespaces. These spongeswillexpandsospecialcaremustbetakenwhen incisions becausetheymayinterferewithhealingofskinedges. Note: GelatinSpongesshouldnotbeusedinclosureofskin They maybecutintosmallersizes. 7 mm( These GelatinSpongesmeasure20xmm( within fourtosixweeks. can beimplantedduringsurgeryandwillcompletelyabsorbed its meshesmanytimesweightinwholeblood.Thesesponges hemostatic devicethatiscapableofabsorbingandholdingwithin specially treated,purifiedgelatinsolution.Eachspongeisa ST1 72-6806 ST1 72-6805 Order # ST1 59-9863 Order # ST1 59-9863 1 ⁄ 4 in)thick.Theyaresuppliedsterileinajarof12sponges. Instant Ice®SkinRefrigerantStreamSpray Instant Ice®SkinRefrigerantMistSpray Product Absorbable GelatinSponges,pkg.of12 Product web www.harvardapparatus.com Refrigerant Ice® toeaseanimaldiscomfort intravenous lines.UseInstant surgical procedures,andstarting injection anesthesia,minor pain associatedwithpre- vapocoolant usedtocontrol This SkinRefrigerantisa Instant Ice Sponges Absorbable Gelatin sponges arepreparedfrom These small,sterile,surgical ACCESSORIES • • • • • • • within fourtosixweeks Completely absorbed weight inblood Holds manytimesits Highly absorbent Mist orstreamspray Non-flammable Non-prescription use onsmallanimals Topical anestheticfor 3 ⁄ 4

x ® 3 Skin ⁄ 4 in)andare

53 SURGICAL INSTRUMENTS www.harvardapparatus.com web 160.75 mm (without tip) 160.75 g (with two AA batteries) 78 3 V, 1.5 V 5 x 1 mm and 10 x 1 mm Product Gemini Cautery Kit Replacement Gemini 5 mm Cautery Tip Replacement Gemini 10 mm Cautery Tip Simple tip design for easy replacement Uses standard AA batteries Easy screw cap for convenient battery replacement Hard plastic case with die cut foam for convenient storage operation Battery spacer for optional temperature • • • • • Specifications Length Weight Electrical Tip Sizes # Order ST1 72-6067 ST1 72-6068 ST1 72-6069 The Gemini Cautery Kit is the perfect tool for your cauterizing The Gemini Cautery Kit is the perfect tool for two different operating needs. The unique tip sizes combined with The convenient battery temperatures allow for maximum versatility. to low spacer converts the hand piece from high temperature temperature. This kit includes: case, handle, two 5 mm tips and two 10 mm tips. Kit Gemini Cautery m Tip, 254 Micron m Tip, 127 Micronm Tip, 127 [email protected] m Tip, 127 Micronm Tip, 127 m Tip, 254 Micron email

m Tip Sharp 1 µ 1-508-893-8999 Product Etched Tungsten Micro-Needle, Sharp 1 µ Shaft, pkg. of 10 Etched Tungsten Micro-Needle, Sharp 1 µ Shaft, pkg. of 10 Etched Tungsten Micro-Needle, Blunted 5 µ Shaft, pkg. of 10 Etched Tungsten Micro-Needle, Blunted 3 µ Shaft, pkg. of 10 To order call For very fine micro-dissections Sharp or blunt tips available Provides lateral stability Minimal spring action • • • • # Order ST1 72-0422 ST1 72-0423 ST1 72-0424 ST1 72-0425 These micro-needles are for micro-dissections. They are made from These micro-needles are for micro-dissections. sharp 1 micron tip or a high quality tungsten. Select from either a blunted 3 or 5 micron tip. well as minimal spring All micro-needles provide lateral stability as action during manipulation. and are supplied in a These micro-needles are 12 mm (0.5 in) long or 254 micron shaft. package of 10. Select from either a 127 Micro-Needles Tungsten Etched ACCESSORIES

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INSTRUMENTS 54 Note: IH-SRCannulaearenotcompatiblewithLuerfittings heart tomountspecificallyontheIH-5System. These specialcannulaeweredesignedforcannulatingisolated Aortic Cannulaeto IH-5System System. specifically ontheIH-SR isolated hearttomount designed forcannulating These specialcannulaewere to IH-SRSystem Aortic Cannulae appropriate flowsensor. working heartbyconnectingthe to measurecoronaryflowona metabolism analysis. It allows also measuring gasconcentrationsor the effluateofheartfor possible. Itisusedforcollecting cannula ontheheartandvesselis without stressloadfromthe joint holdersaprecisefixation combination withtheminiball on isolatedperfusedheart.In to canulatethepulmonaryartery This specialholderwasdesigned ArteryPulmonary Cannulating System for Ball JointHolderand ST1 73-2880 ST1 73-2879 ST1 73-2878 ST1 73-2877 ST1 73-2876 ST1 73-2875 ST1 73-3065 Order # ST1 73-2862 ST1 73-2861 ST1 73-2814 ST1 73-2860 ST1 73-2859 ST1 73-2858 ST1 73-2857 ST1 73-2816 Order # ST1 73-0206 ST1 73-2934 Order # To order call 1-508-893-8999 Aortic CannulatoIH-5,OD6.0mm Aortic CannulatoIH-5,OD5.0mm Aortic CannulatoIH-5,OD4.0mm Aortic CannulatoIH-5,OD3.5mm Aortic CannulatoIH-5,OD3.0mm Aortic CannulatoIH-5,OD2.5mm Aortic CannulatoIH-5,OD2.0mm Product Aortic CannulatoIH-SR,OD3.0mm Aortic CannulatoIH-SR,OD2.5mm Aortic CannulatoIH-SR,OD2.3mm Aortic CannulatoIH-SR,OD2.0mm Aortic CannulatoIH-SR,OD1.8mm Aortic CannulatoIH-SR,OD1.5mm Aortic CannulatoIH-SR,OD1.3mm Aortic CannulatoIH-SR,OD1.0mm Product Rat /GuineaPigHeartsforanysystem Ball JointsandCannulatingSystemforPulmonaryArteryon Rat /GuineaPigHeartstoIH-SR Ball JointsandCannulatingSystemforPulmonaryArteryon Product

email [email protected]

joint mini ball ball with T -Connector holders artery pulmonery cannula for thread build universalperfusioncannulatingsystems. These cannulaecanalsobecombinedwithMiniBallJointHoldersto chamber. The cannulaearealsoavailableascannulatingsystemtothemoist port forpressuremeasurementordrugapplication. different sizesdependingonthespeciesandwithorwithoutside during preparationandexperiment.Thecannulaeareavailableat equipped withabasketliketiptoavoidanyocclusionofthevessel cannulation ofanisolatedperfusedliverorkidney.Thecannulaeare These specialcannulaeweredesignedfornontraumatic Cannulae for Isolated Liver orKidney Perfusion ST1 73-2778 ST1 73-2777 ST1 73-2947 ST1 73-0729 ST1 73-3315 ST1 73-3313 ST1 73-3311 ST1 73-3309 ST1 73-3314 ST1 73-3312 ST1 73-3310 ST1 73-3308 Order # Cannulae forIsolatedLiver Gemini CauterySystem Holder toMoistChamber Ex VivoCannulawithBasketandSidePortOD2.3mm Holder toMoistChamber Ex VivoCannulawithBasketandSidePortOD1.3mm Holder toMoistChamber Ex VivoCannulawithBasketandSidePortOD1.0mm Chamber Ex VivoCannulawithBasketOD1.3mmandHoldertoMoist 1.0 mmandHoldertoMoistChamber In SituCannulawithBasketExVivoOD In SituCannulawithBasketandSidePortOD2.0mm In SituCannulawithBasketandSidePortOD1.3mm In SituCannulawithBasketandSidePortOD1.0mm In SituCannulawithBasketOD2.3mm In SituCannulawithBasketOD2.0mm In SituCannulawithBasketOD1.3mm In SituCannulawithBasketOD1.0mm Product web ORGAN CANNULATION www.harvardapparatus.com Cannulae forIsolatedKidney

55 SURGICAL INSTRUMENTS

in) square 2 ⁄

1

ST1 55-0012 Small Decapitator www.harvardapparatus.com web Product Small Decapitator, 20 x 15 x 20 cm (8 x 6 x 8 in), Dimensions, H x W x D cm (17 x 9 x 14 in),22.5 x 35 x Large Decapitator, 42.5 Dimensions, H x W x D Replacement Top Blade for Small Decapitator Replacement Bottom Blade for Small Decapitator Replacement Top Blade for Large Decapitator Replacement Top Blade for Large Decapitator

Cuts through bone tissue; sharp enough to cut hair Cuts through bone tissue; sharp enough use Handle can be relocated for right- or left-hand • • ST1 55-0020 Large Decapitator # Order ST1 55-0012 ST1 55-0020 ST1 55-0013 ST1 55-0014 ST1 0135004 ST1 0135007 and weighs 1.8 kg (1 lbs). It is used for rats, mice and other small and weighs 1.8 kg (1 lbs). It is used for rats, blade opening of animals. The large decapitator has a maximum lbs). It is used for rabbits, 102 mm (4 in) square and weighs 4.1 kg (9 small monkeys and similar sized animals. These decapitators have two hardened, grounded and polished These decapitators have two hardened, grounded base and stainless surgical stainless steel blades, a cast aluminum permanent mounting to steel hardware. The base has four holes for a table top. and large. The small Two sizes of decapitator are offered; small of 38 mm (1 decapitator has a maximum blade opening Decapitators

Blades for mouse and rat pig and rabbit Blades for guinea [email protected] email 1-508-893-8999

Product Small Guillotine for Mouse and Rat Large Guillotine for Guinea Pig and Rabbit Replacement Blades for Small Guillotine To order call – For mouse and rat – For guinea pig and rabbit Two different sizes: Cuts through bone tissue Protecting sheet at handle Protecting plexiglas cover at knife Locking device prevents unintentional fall of knife Bolting of knife in final position Knife can only be moved when security trigger guard is activated • • • • • • • Guillotine ST1 73-1918 ST1 73-1920 ST1 73-1919 # Order The Guillotine provides instant decapitation of The Guillotine provides instant decapitation laboratory animals. It is available in two versions. of The small version has a maximum opening mm and is used for small rodents; mice and rats. The large 65 and is used for guinea version has a maximum opening of 85 mm pigs and rabbits. A swift downward thrust of the handle dispatches rats, mice and other experimental subjects quickly and without trauma. The blades consist of two different metals - the fixed blade is stainless steel, the movable blade is bronze - ensuring excellent cut and avoiding scuffing tendency because of the excellent anti- friction properties of these two metals. Spare blades are available. A security guard ensures that the movable blade stays up when guillotine is not in use so that no unexpected movement down may take place. Protecting cover and locking devices provide a maximum of safety for the user. The entire unit is completely washable. No need to disassemble. Also ideal for cutting plastic tubing. HSE Guillotines DECAPITATORS

SURGICAL

INSTRUMENTS 56 SURGICAL EQUIPMENT

Surgical equipment such as operating tables, temperature control products, surgical lights and magnifiers are essential to a prepared surgical suite. Harvard Apparatus offers many different options to meet your application needs. Temperature control products include homeothermic blanket systems and heat therapy pumps which are ideal for keeping animals warm during surgical procedures. Surgical tables are available that are heated, homeothermic or standard, as well as specially designed tables for mice and rats. Good lighting and magnification improves surgical technique and surgical outcomes.

PRODUCT PAGE

Homeothermic Blanket Systems...... 58-59 Small Animal Operating Tables...... 60-65 Surgical Retractor System...... 66-67 Thoracic Positioners...... 68 Large Animal Operating Tables...... 68-69 Heat Therapy Pump and Pads...... 70 Digital Thermometers for Evaluating Body Temperature...... 71 Temperco for Pyrogen Testing...... 72 Thermocouple Thermometers...... 73-74 TCAT-2 Temperature Controller...... 75-76 Portable Digital Thermometer...... 76 Thermocouple Probes...... 77-81 Non-Contact InfraRed Thermometer...... 82 Precision Thermistor Thermometer...... 82 YSI 400 Series Thermistor Probes...... 83-84 InfraRed Thermometer for Cutaneous Tail Temperature in Rodents...... 85 Intensive Care Units...... 86-87 NEW Warm Air Chamber...... 87 “Vetcare" Heated Chamber System...... 88 Thermal Barrier...... 88 Small Animal Recovery Chamber/Warming Cabinet...... 89 CareFRESH Absorbent Sheets...... 89 Magnifiers...... 90-91 Stand Magnifiers...... 92-93 NEW Surgical Lights...... 94-98

APEX Major Surgical Lights,

see page 98 EQUIPMENT SURGICAL

57 50 Hz 230 VAC, ST1 50-7221-F ST1 50-7223-F ST1 50-7225-F www.harvardapparatus.com web 60 Hz 115 VAC, ST1 50-7220-F ST1 50-7222-F ST1 50-7224-F and S J Wigmore: Effect of temperature control upon a mouse model

Product Flexible Probe Only, 1.6 mm OD Rigid Probe Only, 1.6 mm OD Small Blanket Only, 15 x 20 cm (6 x 8 in)* in)* (18 x 27 cm x 70 Medium Blanket Only, 45 x 36 in)* Large Blanket Only, 60 x 90 cm (24 Spare Plastic Cover for Small Blanket Spare Plastic Cover for Medium Blanket Spare Plastic Cover for Large Blanket Control Unit Only, 115 VAC, 60 Hz Control Unit Only, 230 VAC, 50Hz Small Blanket: Measures 15 x 20 cm (6 x 8 in) and is Small Blanket: Measures 15 x 20 cm (6 x 8 in) suitable for rodents in) and is cm (18 x 27 x 70 Medium Blanket: Measures 45 suitable for rabbits and cats x 36 in) and is Large Blanket: Measures 60 x 90 cm (24 suitable for dogs -  -  -   L Devey, M F W Festing of partial hepatic ischaemia/reperfusion injury. LABORATORY ANIMAL, 2008; 42, 12-18. Specifications Size Blanket Small Medium Large # Order ST1 50-7217 ST1 50-7218 ST1 50-7214 ST1 50-7215 ST1 50-7216 ST1 50-7178 ST1 50-7194 ST1 50-7210 ST1 50-7212 ST1 50-7213 * Note: Spare plastic covers need to be ordered separately. References: 1. The blanket consists of a highly flexible insulated heating element, a highly flexible insulated heating element, The blanket consists of risking internal damage. It is which can be folded without however, one end of the electrically floating with respect to ground on the front panel of heating element can be grounded by a switch whether or not the the control unit. The system operates correctly blanket is grounded. comes with Blankets are available in three sizes and each a 2 m (6 ft) cable to attach to the control unit: unit, flexible Each system is supplied complete with control for the blanket. temperature probe, blanket and plastic cover the Rodent Operating The operating table version is supplied with for complete details Table instead of a blanket. See pages 60-61 on the table. [email protected] email 1-508-893-8999 To order call - Homeothermic control - Stand alone digital thermometer Feedback loop maintains animal temperature displayed Set temperature and actual temperature continually on screen Two modes now available: Audible & visual alarms user set for minimum Audible & visual alarms user set for minimum and maximum points rabbits and Versatile – offered in three sizes; rodents, cats/dogs or similar sized animals menu option Centigrade or Fahrenheit selection set by • • • • • • Place the animal on the blanket for procedures and recoveries. For Place the animal on the blanket for procedures tightly in the heating more exact body temperature wrap the animal temperature-sensing blanket, using tape if necessary. Insert the (20° to 50°C) probe rectally, and set the desired body temperature on the front panel of the control unit. Should the animal’s core temperature fall, power is automatically increased to the blanket; conversely, power will automatically reduce if the animal’s temperature rises. During this process the animal’s actual body temperature and the set temperature are continuously displayed on the front panel display. The flexible probe is a precision thermistor encapsulated in a bead of epoxy resin at the top of a flexible hollow plastic tube. The 1.6 in) long and has a 2 m (6 ft) long mm diameter probe is 100 mm (4 cable with plug for attachment to the control unit. It is suitable for a wide range of laboratory animals from adult mice to large dogs. The output of the temperature sensing probe is used by the control unit to proportionally control the DC supply to the blanket. This method of control alleviates the interference problems associated with that of non-proportional control, such as switching contacts, thus enabling the system to be used in conjunction with high-gain recording systems. The system has a large vacuum fluorescent display so you can The system has a large vacuum fluorescent easily see the temperature selected. Simple and Easy Large Display Large Systems Monitoring Homeothermic HOMEOTHERMIC MONITORING SYSTEMS MONITORING HOMEOTHERMIC

SURGICAL

EQUIPMENT 58 Key Features control unit. be visualizedsimultaneouslyon two differentdisplaysontheHB121 the controlunit.Bothblanketand animalbodytemperaturescan selecting theprobewhichtemperature willbeusedasreferenceby parallel (onetotheblanketand one totheanimal).Aswitchallows In theHB121ControlUnit,two probescanbeconnectedin probe associatedtotheblanketoranimal(rectalprobe). In theHB101 ControlUnit,theheatismaintainedbyathermistor between 32° to45°C. The unitallowstheusertoadjustanimalbodytemperature electrical noiseinterferencesonsurroundingelectronicapparatus. Control Units,workingwithaDCpowersupplytominimize The heatoftheblanketismaintainedbyHB101 orHB121 blanket. surgery asitfitsperfectlyintothestereotaxicframe,orasoft The blanketscanbeahardrigidpad,suitableforstereotaxic increases thetemperatureofblanket. When thebodytemperaturefallsbelowtarget,controlunit by thelineartemperatureprobeconnectedtocontrolunit. front panelofthecontrolunit.Thebodytemperatureiscontrolled The desiredbodytemperature(32° to45°C) iseasilysetbythe probe. Allcomponentsmustbeorderedseparately. consists animals (mouse,rat,hamsterorrabbit).Acompletesystem a precisecontrolofthebodytemperatureinsmalllaboratory The Panlab/HarvardApparatusHomeothermicSystemallows Parameters Measured Body Temperature inSmallAnimals Homeothermic System for Controlling To order call • • • • • • (rat, mouse,hamster,rabbit) Models availableforanumberofspecies match desiredanimal’sbodytemperature Control unitraises/lowerstemperatureinorderto Electrical noiseavoidedthankstoDCpowersupply temperature probes Interchangeable andprecalibrated Animal rectaltemperature Blanket temperature

of acontrolunit,blanketorpadandtemperature 1-508-893-8999 email [email protected]

HOMEOTHERMIC MONITORINGSYSTEMS are interchangeablewithnolossofaccuracy. The homeothermicsystemusescalibratedthermistorprobeswhich temperature dataatselectedtimeperiodsviaaPC. output. SeDaComsoftwarecanbepurchasedtoallowviewingof The controlunit(HB101 orHB121)isavailablewithanRS-232 4. 3. 2. 1. References: * Note:RequiresST176-0608 Adapter. RS-232/USB directly fromtheSeDacomapplication. of thecurrentdatatoPCatuser-selectedtimeintervalsprogrammed Additionally, theWindows-basedprogramSeDaComallowstransfer Computer Requirements Temperature ProbeDiameter: Resolution Temperature Range Specifications ST1 76-0608 ST1 76-0406 ST1 76-0111 ST1 76-0068 ST1 76-0067 ST1 76-0066 ST1 76-0388 ST1 76-0389 ST1 76-0390 ST1 76-0386 ST1 76-0387 ST1 76-0385 ST1 76-0290 Order # mice. Laboratory Animals, 43(1): 27-33 (HB101, mouse, Portugal). mouse, (HB101, 27-33 43(1): Animals, Laboratory mice. in fentanyl and medetomidine propofol, with anaesthesia Intraperitoneal (2009) al. et HC Alves Neuropharmacol. 54(5):885-900. (HB121, rat, Spain). rat, (HB121, 54(5):885-900. Neuropharmacol. rats. in neurotoxicity serotonin 3,4-methylenedioxymethamphetamine-induced in metabolism peripheral and tyrosine of role the On (2008) al. et B Goñi-Allo Caveolin-1 Knock-out (KO) mice. Am. J. Physiol. Renal Physiol. (HB101, mouse, Sweden). mouse, (HB101, Physiol. Renal Physiol. J. Am. mice. (KO) Knock-out Caveolin-1 in Barrier Filtration Glomerular the of Size-selectivity Unaltered (2009) al. et G Grande infusion of signalling molecules implicated in migraine. Cephalgia. (rat, Denmark) In Press. In Denmark) (rat, Cephalgia. migraine. in implicated molecules signalling of infusion intracarotid by rats in model window cranial closed the of Improvement (2009) al. et Gupta ST1 76-0066 ST1 76-0067 ST1 76-0068 – – RS YS451 YS402 YS401 HBRB HBS HBSM HBH HBM HB101 HB121 Model web www.harvardapparatus.com SeDaCom Accessory–RS232/USB Adaptor for datatransfertoacomputer SeDaCom Software(2.0) (SeDaCom Softwarenotincluded) RS-232 CommunicationsPort Temperature ProbeforMouse Temperature ProbeforMouse/Rats Temperature ProbeforRabbit Rabbit Blanket,40x70cm(15.627.6in) Rat Blanket,15x25cm(5.99.8in) Mouse Blanket,10x15cm(3.99.8in) Rat Pad,10.5x23cm(4.19.1in) Mouse Pad,9x11.4cm(3.54.5in) with 1TemperatureDisplay Homeothermic ControlUnit Power 115-220VAC,50/60Hz Temperature Probes,Range32°to45°C, Homeothermic ControlUnitfor2 Product 4.2 mmYS401 Probe 3 mmYS402 Probe PC (Windows 95, 98, ME, NT, 2000 and XP) PC (Windows95, 98,ME,NT,2000andXP) 1.3 mmYS451 Probe 0.1°C 32°-45°C

59 SURGICAL EQUIPMENT

Size 5 mm,300 x 195 (11.8 x 7.7 in) Aluminium, Plastic coated From 160 to 180 mm (6.3 x 7.1 in) (Horizontal position) mm (2.2 in) 55 Printed circuit board 1.5 Ω kg (1 lbs) 0.45 0.60 kg (1.3 lbs) kg (3.9 lbs) 1.75 0.3 kg (0.7 lbs) Size 5 with Homeothermic Controller Size 5 with Homeothermic

in association with the controllers. maintained and for safety shutoffmaintained and for safety the temperature of the table isthe temperature of the table of temperature control required. Theof temperature control required. haveheated operating table models elementa built-in embedded heating to ensureand temperature probes heated operating table are levelavailable depending on the Three different versions of theThree different versions www.harvardapparatus.com web DC 9 Volt, 40 VA adjustable in the range 20 - 100% Hz Version Hz Version, or 115 VAC/60 230 VAC/50 in) x 3.8 x 8.3 x 210 mm (4.9 125 x 95 lb) 2 kg (4.4 Size 1 mm,160 x 95 (6.3 x 3.9 in) Aluminium, Plastic coated 105 mm (4.1 in) 105 mm (4.1 (Horizontal position) mm (1.8 in) 45 Printed circuit board 6 Ω 0.2 kg (0.4 lbs) 0.3 kg (0.7 lbs) kg (3.4 lbs) 1.55 0.10 kg (0.2 lbs) Size 1 with Heating Controller Size 1 with Fixed Temperature Controller) (Heating Specifications Power Output Mains Voltage Dimensions Weight Table) (Operating Specifications Table Plate Height with Tripod Height with Flat Base Heating Element Heater Resistance Weight Plate (with Heating) Weight Plate (without Heating) Weight Plate Tripod Weight Flat Base Model Heated Temperature Fixed Advanced The 872/1 Controller with Heating In this version, there is no feedback control. The table is heated and maintained at a stable temperature by controlling the amount of DC-energy to the heating element. On the controller the energy is adjustable in a range of 20-100% of the maximum energy. The controller also ensures the safety shutoff. These models are often used for quick surgical procedures or acute animal studies (30 minutes or less) requiring the core temperature of the animal be maintained. To adjust the controller an electronic thermometer for measuring the animal body temperature is used. [email protected] email

Size 1 with Flat angled Stand Size 5 with Flat angled Stand 1-508-893-8999 With heating controller and tripod or flat With heating controller and tripod or flat angled base With heating, homeothermic temperature controller and tripod or flat angled base To order call - Non-heated with tripod or flat angled base - Non-heated with tripod or flat angled or flat - With heating, power supply and tripod - angled base -  -  For general surgical work on small animals For general surgical work on small animals (mouse, rat, and guinea pig) size: Eight different versions available for each Includes paw holders Capable of receiving thorax retractors and mounting ball joint holders • • • • Size 1 with Tripod Stand with ball joint Size 1 with Tripod Stand with Size 5 with Tripod Stand with ball joint Eight different configurations are available for each size of the Eight different configurations are available larger rodents. Each operating table, size 1 for mice or size 5 for Experimental configuration is equipped with four paw holders. requirements and user’s preference dictate the preferred configuration. The core component for the operating tables is a plastic coated aluminum plate measuring 160 x 100 mm 7.7 in) for the mm (11.8 x (6.3 x 3.9 in) for the size 1 and 300 x 195 size 5. Both sides of the plate have multiple slots for fixing the paw holders and optional thorax retractors. Numerous slots and dedicated paw holders allow both large and small animals to be held firmly in position for optimal surgical access. A block clamp with ball joint holder can be fixed onto the plate for holding various probes, electrodes, or cannulae. A 4 mm banana plug outlet is available when grounding of the table is required (e.g. for ECG recordings). Two different models of the mounting base are available, the traditional tripod stand mounted on a ball joint allowing the table to tilt in multiple directions or the flat angled version with a lower profile consuming less working height. The non-heated operating table models are recommended only for necropsy studies or short term anesthetized animal experiments such as procedures calling for the removal of isolated organs or tissues. These models are not upgradeable to heated versions. Mice, 1 for Size Tables Operating Rodents 5 for Size OPERATING TABLES OPERATING

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EQUIPMENT 60 eliminates electricalnoisethuspermittingsensitiverecordings. a switchonthefrontpanelofcontrolunit.Specialcircuitry however, oneendoftheheatingelementcanbegroundedby The operatingtableiselectricallyfloating,withrespecttoground built-in theoperatingtable. operating tableto40°C.Thiscircuitusesasecondthermistorprobe as asafetycircuitbylimitingthemaximumtemperatureof control ofthemaximumtemperatureoperatingtable.Itacts The adapterconsistsofaseparateboxincludingthepermanent delivered. temperature thebargraphwillindicatemaximumpowerbeing table. Whencoretemperatureissubstantiallybelowthedesired indicates thelevelofpowerbeingdeliveredtooperating displays theprobetemperature.AhorizontalLEDbargraph on thefrontpanel.AnLCDdisplaycontrolunitcontinuously be adjustedwithintherangeof35° to40°Cbymeansofacontrol The controltemperatureispresetat37°C atthefactory,butcan control, found­ the interferenceproblemsassociatedwiththatofnon-proportional DC supplytotheoperatingtable.Thismethodofcontrolalleviates control unittoproportionallytheregulated,low-voltage The outputofthetemperaturesensingprobeisusedby animals fromadultmicetoratsandguineapigs. to thecontrolunit.Itissuitableforawiderangeoflaboratory (4 in)longandhasa2m(6ft)cablewithplugfor attachment flexible hollowplastictube.The1.6mmdiameterprobeis100 thermistor encapsulatedinabeadofepoxyresinatthetop a controlunit,andanadapterbox.Theflexibleprobeisprecision The HomeothermicOperatingtablesconsistofthreeparts:aprobe, The HomeothermicControlled Version The temperatureoftheoperatingtableisfixedto38°C. temperature viathesensorbuilt-inoperatingtable. control oftheoperatingtabletemperature.Itcontrols The adapterconsistsofaseparateboxincludingthepermanent with Adapter Box andPower Supply The BasicFixed Temperature Heated Model Weight Dimensions, WxH xD Mains Voltage Analogue Output Safety Limit Temperature Temperature Range Temperature Accuracy Ripple Output Power Output Specifications (HomeothermicControl) Weight Power Supply Dimensions Mains Voltage Power Output Specifications (Heated Modelwith Power Supply) To order call 1-508-893-8999 with highgainrecordingsystems. 3 kg(6.6lb) 274 x320 x94 mm (10.8x12.63.7in) or 115VAC,60HzVersion 230 VAC,50HzVersion, 50 mVat35°C to150mV at 40°C(20mv/°C) 40°C 35° to40°Cmonitoredon thefrontpanelLCD ±1% ofactualtemperature(35° to40°C) Less than10mVRMS the temperaturemonitored (not switched),thelevelisdependenton Maximum 40VA.Suppliedcontinuously 0.6 kg 140 x6030mm(5.52.41.5in) Adapter box105x55 x30mm(4.1 x2.21.5in) 115 VAC/60 Hz-230VAC/50 Hz 12 VDC/60VA email [email protected]

Flexible Probefor All Systems,1.3mmOD Holder forAnesthetic Mask Holder withBallJoint Holders for2CannulaewithBubbleTrap Small HolderLinkforHigherLoading Thorax RetractorwithBallChain,1pair Electrodes &Cannulae Replacement HolderforClampingProbes, Replacement PawHolders,pkg.of5 Accessories forTables 230 VAC,50Hz Flat AngledBase,HomeothermicController, 115 VAC,60Hz Flat AngledBase,HomeothermicController, 230 VAC,50Hz Flat AngledBase,HeatingController, 115 VAC,60Hz Flat AngledBase,HeatingController, with PowerSupply115/230 VAC,50/60 Hz Flat AngledBase,Heated Flat AngledBase,Non-Heated 230 VAC,50Hz Tripod Base,HomeothermicController, 115 VAC,60Hz Tripod Base,HomeothermicController, Tripod Base,HeatingController,230VAC,50Hz Tripod Base,HeatingController,115VAC,60Hz 115/230 VAC Tripod Base,HeatedwithPowerSupply Tripod Base,Non-Heated Operating Tables ST1 73-3855 ST1 73-3945 ST1 73-3748 web ST1 73-3854 www.harvardapparatus.com

OPERATING TABLES

ST1 73-3822 ST1 73-3856 ST1 73-3857

ST1 73-7217 – – – ST1 73-3945 ST1 73-3822 ST1 73-3854 ST1 73-3753 ST1 73-4234 ST1 73-4232 ST1 73-3773 ST1 73-3772 ST1 73-3775 ST1 73-3768 ST1 73-4233 ST1 73-4231 ST1 73-3771 ST1 73-3770 ST1 73-3774 ST1 73-3754 Size 1 ST1 73-7217 ST1 73-3748 ST1 73-3856 ST1 73-3857 ST1 73-3945 ST1 73-3822 ST1 73-3855 ST1 73-3512 ST1 73-3980 ST1 73-3976 ST1 73-3585 ST1 73-3586 ST1 73-3777 ST1 73-3530 ST1 73-3979 ST1 73-3975 ST1 73-3582 ST1 73-3584 ST1 73-3776 ST1 73-3529 Size 5

61 SURGICAL EQUIPMENT

in) 8 ⁄ 3 in) Frog Board is 2 ⁄ 1 x 5 2 ⁄ 1 www.harvardapparatus.com web

Product Frog Board in) thick white acrylic. A clamp and locking screw are mounted in) thick white acrylic. A clamp and locking 2 ⁄ 1 # Order ST1 50-3565 diameter rod (not supplied), see the clamps, stands and lattices diameter rod (not supplied), see the clamps, on our website. To prevent warping, this 9 x 14 cm (3 ( Board Frog made of a thick piece of cork cemented to a heavy piece of 12.5 mm made of a thick piece of cork cemented to on the side with an opening to fit a standard 9.5 mm ( on the side with an opening to fit a standard

[email protected] email 1-508-893-8999

Product Mini-OP Table & Accessories To order call precisely where it is needed. The edge clamps can be fitted to the rods to give greater flexibility of use. They and are made from tough plastic with nylon screws. Rod (1 supplied): It is useful for positioning equipment crocodile clips. Uprights (2 supplied): They fit into the table slots to provide a 5 mm (0.2 in) diameter bar to which equipment can be attached. Bossheads (2 supplied): They are used with the uprights Crocodile clips (4 supplied): They are used to secure supplied): Crocodile clips (4 in) long ball the animal during necropsy. 150 mm (5.9 chain and connector are included. rods Retractors (6 supplied): These stainless steel be bent into measure 50 mm (2 in) in length. They can and connector the desired shape. 150 mm (5.9 in) chain included. Edge clamps (6 supplied): They can be clamped around the edge of the table to accommodate retractors and are manufactured in stainless steel and measure 200 mm (7.9 in) long and 5 mm (0.2 in) in diameter.

• • • • • •

# Order ST1 34-0294 Mini-OP Table small animals, the Designed specifically for operative work in the patient is always Mini-OP Table tilts in any direction to ensure slots to accommodate presented to the best advantage. It contains be used. uprights so that additional equipment can the base and can be The table top stands 150 mm (5.9 in) above in lightweight, height adjusted for user comfort. It is manufactured therefore helps to non-absorbent PVC, which retains heat and has non-slip feet. maintain body temperature. The metal base Accessories supplied with the Mini-OP Table: OPERATING TABLES OPERATING

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EQUIPMENT 62 Options Components Included Parameters Measured Small AnimalOperating Tables To order call • • • • • • • • • • • • • experimentation (OT200model) temperature probeappliedto the animalunder HB121 displayssurfacetemperature andcontrols Two slotsforfixingsurgeryaccessories(OT100model) Four slotsforholdingtheanimalinposition Tripod stand Table Animal rectaltemperature(OT200model) Table temperature(OT200model) for OT200 Electrical noiseavoidedthankstoDCpowersupply Uniform heatdistributionforOT200 Thermal controloptionavailableforOT200 Tilting platform Holds foreasierfixationofanimal’sextremities Non-absorbent surface 1-508-893-8999 email [email protected] Small AnimalOperatingTable Two different modelsare available: of thesystemduringwholesurgeryprocess. easily tiltinvariousdirections.Non-slipfeetinsureastableposition mounted onatraditionaltripodstandallowingtheplatformto or placementoftheflushinglineduringsurgery.Thetablesare platform hasgroovesrunningbothitslengthandwidthfordrainage allowing largeandsmallanimalstobeheldfirmlyinplace.The animal. Fourslotsarepositionedinthecornersofplatform, surgery andprovideexcellentaccesstotheentirelengthof piece moldedtablesholdrodentsandothersmallanimalsduring general surgicalworkonsmalllaboratoryanimals.Theseone- Panlab/Harvard Apparatusfeaturesasetofoperatingtablesfor ST1 76-0290 Options ST1 76-0288 ST1 76-0287 Order # Dimensions, HxWD: Material Composition Specifications OT200 OT100 –  –  purchased separately. on theHB121controlunit.Thetableandunitare be visualizedsimultaneouslyontwodifferentdisplays probe. Tableheatandanimalbodytemperaturescan associated temperatureprobeorarectalthermistor 34° to45°C. Theheatismaintainedbythetable- allows theusertoadjustbodytemperaturebetween measurements, suchaselectrocardiogram.Theunit with theregistrationofsomeanimalphysiological power supplytominimizeanyACrippleinterference maintained bytheHB121controlunit,workingwithaDC uniform heatdistribution.Theoftheplatformis durable anodizedaluminumplatformallowinga The operatingtableisconstructedofanextremely the controlofanimaltemperatureduringsurgery. Operating Tableisahomeothermictableallowing The Panlab/HarvardApparatusOT200SmallAnimal fixing someuser-definedsurgicalaccessories. platform isalsoprovidedwithasetoflongerslotsfor and easy-to-cleanPVCplatform.Themiddlepartofthe Operating Tableoffersaconvenient,non-absorbent The Panlab/HarvardApparatusOT100SmallAnimal HB121 OT200 OT100 Model web www.harvardapparatus.com 15 x2821cm(5.9118.3in) 15 x32 x22cm(5.912.68.7in) PVC (OT100) or anodized aluminum (OT200) PVC (OT100)oranodizedaluminum(OT200) Includes RectalProbe Temperature ControlforOT200, Small AnimalOperatingTable,Homeothermic Small AnimalOperatingTable,Tilting Product OPERATING TABLES

63 SURGICAL EQUIPMENT www.harvardapparatus.com in) rod is mounted on a simple slotted in) rod is mounted on web 16 ⁄ 1 lb). 2 ⁄ 1 Product Table, 115 VAC, 60 Hz Heated Rodent Operating Table, 230 VAC, 50 Hz Heated Rodent Operating Replacement Cork Mat Probe,Homeothermic Rodent Operating Table with Flexible 115 VAC, 60 Hz Probe,Homeothermic Rodent Operating Table with Flexible 230 VAC, 50 Hz UnitsControl Homeothermic with use for Only, Table Heated ST1 50-7129 and ST1 50-7137 in) diameter rods and four tying cleats are supplied with in) diameter rods and 4 ⁄ 1 # Order ST1 50-1205 ST1 50-1213 ST1 50-1221 ST1 50-7226-F ST1 50-7227-F ST1 50-7152 clamp with a locking screw. The table is mounted on a heavy base screw. The table is mounted on a heavy base clamp with a locking in). It 26 cm (8 x 10 The top measures 20 x fitted with non-slip feet. weighs 4.3 kg (9 the table. Each 20.4 cm (8 the table. Each 20.4 cm The Homeothermic Rodent Operating Table includes a rectal Table includes Rodent Operating The Homeothermic unit. control sensitive a and OD) mm (1.6 probe sensing temperature the animal’s core temperature continuously monitors The system adjusts the controller, automatically and, through the during surgery and control details on the probes For complete table temperature. 58. unit, see page are supplied with a cork mat that has a These operating tables holding the animal. Four stainless steel cutout in the center for 6.5 mm ( [email protected] email 1-508-893-8999

To order call Available as stand alone table or as complete Available as stand alone table or as complete homeothermic heated table Uniformly heated with temperature regulation • • ST1 50-1205 Heated Rodent Operating Table The Heated Rodent Operating Table is a sturdy piece of equipment The Heated Rodent Operating Table is a sturdy portion of the table that will stand up to daily use. The entire top sturdy ball and socket is mounted on a heavy base by means of a swiveled and tilted into joint. The socket allows the table top to be in place. any convenient position and then locked securely The stand alone table has a warming chamber under the table top and contains a small, metal-sheathed 40 watt heater. An energy regulator controls the table top surface varying the heating cycle when necessary. The regulator is calibrated from “full” to “off ” through ten marked points. Uniform heat distribution is maintained over the entire surface by an insulation barrier located between the woven resistance mat and stainless steel top. Table Operating Rodent Heated OPERATING TABLES OPERATING

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EQUIPMENT 64 the table.Each20.4cm(8 steel top.Fourstainless6.5mm( insulation barrierlocatedbetweentheresistancematandstainless Uniform heatdistributionismaintainedoverthetotalsurfacebyan when theregulatorisswitching. procedures. Indicatorlightsarevisiblewhentheheaterisonand points. Thisallowsadequateheatingcontrolformostoperating The regulatoriscalibratedfrom“full”to“off”throughtenmarked the tabletopsurface,varyingheatingcyclewhennecessary. controlled byanenergyregulator.Anregulatorcontrols beneath thistopcontainsasmallmetalsheathed40wattheater steel measuring23x33cm(913in).Awarmingchamberlocated The topisaflat,heavygauge,biologicallyinertpieceofstainless Heated SmallAnimalOperating Table be usedinatiltedposition. edge intoposition.Foldinglegsunderthetableallowto at anypointaroundtheedgeoftableorcanbeslidalong strings securelyinplace.Thesecleats,liketherod,canbeinserted screw. Thetopofthecleathasataperedslotthatbindsanytying clamps tofitovertheedgeoftableandsecurewithalocking cleats arealsosuppliedwhichhaveadeepslotsimilartotherod edge ofthetableorslidalongintoposition.Fourtying of thetableandallowsrodtobeinsertedanywherealong clamp withalockingscrew.Theslotofthisfitsovertheedge ST1 50-1247 ST1 50-1239 Order # To order call Operating Table Heated SmallAnimal Includes DigitalDisplay • work onsmallanimals This operatingtableisgoodforgeneralsurgical 1-508-893-8999 Heated SmallAnimalOperatingTable,230VAC,50Hz Heated SmallAnimalOperatingTable,115VAC,60Hz Product 3 ⁄ 16 in)rodismountedonasimpleslotted email 1 ⁄ 4 in)rodsaresuppliedwith [email protected] Plastic Operating Boards five restrainingcordsforquicktie-downofanimals. Each issuppliedwithfourcleats,onemountedateachcorner,and tilts theboardtoa30°angle. animal. Suctioncupsonthefeetholdunitsteady.Afoldingleg The RabbitBoardhasa“V”designforeasypositioningofthe positioning oftheanimal.Fluidsdraintocenterboard. The SmallRodentBoardhasabuilt-in“V”designforeasy one endoftheboardforspecialpositioning. animal. Fluidsdraintothesidesandafoldingmetallegelevates large rodentboardhasaraisedcenterforeasilypositioningthe locking cleatsquicklyandeasilyattachtheanimaltoboard.The length oftheanimal.Aquick-releasesystemrestraintcordsand animals duringsurgery.Theyprovideexcellentaccesstotheentire These one-piecemoldedboardsholdrodentsandothersmall ST1 52-0452 ST1 52-0445 Order # ST1 59-6942 • the animal Provides excellentaccesstotheentirelengthof Rabbit Small Rodent Board Large Rodent web www.harvardapparatus.com OPERATING TABLES (24 x12in) 60 x30cm (11 x4 27.9 x11.4cm L xW Dimensions, (16 x5 40.6 x13cm 1 1 ⁄ 2 ⁄ 8 in) in) (0.3 lbs) Up to125g – (1.1 lbs) Up to500g Range Max. Weight

20.3 cm(8in) – 35.6 cm(14in) of Animal Length

65 SURGICAL EQUIPMENT

www.harvardapparatus.com web of two retractor arms 1.5 ml collection well (drain plugged) Accepts ¼ in ID Tygon® formulation S-50-HL Noryl® plastic in) x 6 x 1.5 30.1 x 15.5 x 4.0 cm (11.75 perimeter slots on tray and 10 slots on each32 or equivalent Up to 1.6 kg (3.5 lb) per Tension elastic stay Disassembled, non-sterile, elastic stays sold separately Cold sterilize only Product Small Animal Surgery Tray # Order ST1 72-2590 Fluid Collection Drain Hole Specifications Composition Inside Dimensions Stay Slots Maximum Retraction Packaging Sterilization Neryl is a registered trademark of SABIC. Tygon is a registered trademark of St. Gobain. A complete system consists of three components; the small animal A complete system consists of three components; either a small or large plastic retractor surgery tray (ST1 72-2590), and elastic stays, see facing page. or ST1 72-2592) ring (ST1 72-2591 All components must be ordered separately. - Tray, see below. - Retractor Ring, see facing page. - Elastic Stays, see facing page. designed to The small animal surgery tray is anatomically or supine position. accommodate small animals in either the prone retractor arms and There are 10 slots on each of two adjustable slots around the perimeter of the tray that accept elastic hook 32 exactly where stays. These ingenious devices retract the incision you need it and with exactly the right amount of tension. They do not obstruct the surgical site. [email protected] email 1-508-893-8999 To order call Ideal for small animals Does not obstruct view of surgical site Adjustable tension Self-retaining design permits surgery without an assistant Provides fully balanced exposure — no bulky site attachments or instruments to obstruct surgical anatomy Versatile design — adapts to the animal during the surgery and incision closure Autoclavable • • • • • • • Tray Surgery System Small Animal Retractor SURGICAL RETRACTORSURGICAL SYSTEMS

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EQUIPMENT 66 2-Finger Stays Single HookStays, SolidSilicone are available.Seebelowfordetails. perimeter oftheringatpresetlocations.Fourtypeselasticstays without obstructingthesurgicalsite.Thestaysareplacedalong The ElasticStaysprovidepreciseretractionwithadjustabletension Elastic Stays Solid Silicone Single HookStays, ST1 72-2600 ST1 72-2599 ST1 72-2598 Order # ST1 72-2606 Order # Stays Specifications To order call • • Sterilization Maximum Tension Tubing OD Overall Length Composition 4 2-FingerSharpStaysperpackage 6 hooksstaysperpackage 1-508-893-8999 2-Finger SharpStays, 10.0mmHookRadius,Sterile,pkg. of4 2-Finger SharpStays, 7.0mmHookRadius,Sterile,pkg. of4 2-Finger SharpStays,5.0mmHookRadius, Sterile,pkg.of4 Product Non-Sterile, pkg.of6 Single HookStays,SolidSilicone,5.0mmRadius Product Steam orcoldsterilization Up to3.5lb(1.6kg) 3.3 mm(0.13in) 16 cm(6.3in) Silicone andstainlesssteel email Stays 2-Finger [email protected]

SURGICAL RETRACTOR SYSTEMS SURGICAL RETRACTOR Single HookStays Stays Single Hook Deep Tissue BladeStays Retractor Ringhas4. sizes, thelargeRetractorRinghas6thumbscrewswhilesmall to beadaptedtheanatomyofsurgicalsite.Availableintwo using thethumbscrewsalongedgeofringtopermit Different areasoftheRetractorRingmayberaisedorlowered Retractor Ring ST1 72-2591 ST1 72-2592 Order # ST1 72-2604 ST1 72-2603 ST1 72-2602 ST1 72-2601 Order # ST1 72-2596 ST1 72-2595 ST1 72-2593 Order # Retractor Ring Specifications • • Large Ring,LxW Small Ring,LxW Composition 8 HookStaysperpackage 4 BladeStaysperpackage Retractor Ring,Large Retractor Ring,Small Product 20.0 mmBladeWidth,Sterile,pkg.of 4 Deep TissueBladeStays,4-FingerBlunt Style, 14.0 mmBladeWidth,Sterile,pkg.of 4 Deep TissueBladeStays,2-FingerBlunt Style, 13.0 mmBladeWidth,Sterile,pkg.of4 Deep TissueBladeStays,SolidStyle, 6.5 mmBladeWidth,Sterile,pkg.of4 Deep TissueBladeStays,SolidStyle, Product 12.0 mmHookRadius,Sterile,pkg.of8 Single HookStays,LargeStyle,Blunt, 5.0 mmHookRadius,Sterile,pkg.of8 Single HookStays,MediumStyle,Blunt, 3.0 mmHookRadius,Sterile,pkg.of8 Single HookStays,MediumStyle,Sharp, Product web www.harvardapparatus.com 25.0 x14.2cm(9.85.6in) 14.2 xcm(5.65.6in) Lexan Blade Stays Deep Tissue

67 SURGICAL EQUIPMENT

Dimensions, H x W x D 5.7 x 20.3 x 17.8 cm (2¼ x 8 x 7 in) 7 x 25.4 x 20.5 cm (2¾ x 10 x 8 in) x 22.7 cm7.6 x 35.6 (3 x 14 x 9 in) www.harvardapparatus.com Animal Weight Up to 9 kg (20 lb) 9 to 18 kg (20 to 40 lb) kg 18 to 27.2 to 60 lb) (40 web use with For Cats and Small Dogs Medium Dogs Large Dogs Product Stainless Steel Thoracic Positioner Durable, lightweight plastic Transparent to light and x-rays Easy-to-clean Low heat loss • • • • Plastic Thoracic Positioners # Order ST1 59-6435 ST1 59-6436 ST1 59-6437 # Order ST1 59-9525 Positioners Thoracic Plastic These Thoracic Positioners are designed to hold the animal in the desired operating position and are available in three sizes. Since these positioners are constructed of plastic instead of stainless steel, the animal will lose less body heat during surgery. Positioner Thoracic Steel Stainless operating desired the in animal the hold will Positioner Thoracic This gauge stainless steel for durability, this position. Made of heavy rubber feet to hold it in place on any positioner has sure grip table. It measures, H x W x D, flat-top surface or operating cm (3¾8.25 x 30.5 x 26.7 x 12 x 10½ in) and weighs 2.25 kg (5 lb).

[email protected] email Accessories include stainless Accessories 1-508-893-8999 *NOTE: *NOTE: steel instrument tray, removable vertical vertical removable tray, instrument steel and tying cleats. rods 115 VAC, 60 Hz Large Operating Table Fixed Top, Heated Surface, 230 VAC, 50 Hz Large Operating Table Tilt Mechanism, Heated Surface, 115 VAC, 60 Hz Large Operating Table Tilt Mechanism, Heated Surface, 230 VAC, 50 Hz Large Operating Table Tilt Mechanism, Heated Surface & Accessories*, 115 VAC, 60 Hz Large Operating Table Tilt Mechanism, Heated Surface & Accessories*, 230 VAC, 50 Hz Large Operating Table Base Only, 115 VAC, 60 Hz Large Operating Table Base Only, 230 VAC, 50 Hz Large Operating Table Stainless Steel Top Only Large Operating Table Tilt Mechanism Only Product Large Operating Table Fixed Top, Heated Surface, To order call ST1 34-1019 ST1 34-1022 ST1 34-1021 ST1 50-1361 ST1 50-1387 ST1 34-0924 ST1 34-0306 ST1 34-0307 ST1 34-0312 # Order ST1 34-1020 The Harvard Apparatus Large Animal Operating Tables can lift a The Harvard Apparatus Large Animal Operating up to a mm (19.3 in), weight of up to 150 kg (330 lbs) from 490 mm (38.2 in). This minimizes operator lifting injuries height of 970 room environment. within a veterinary or pre-clinical operating options. All These tables are available in heated and non-heated x 23.6 in). All table surfaces tables measure 1,200 x 600 mm (47.2 stainless steel. Other table are made from the finest quality AISI-316 laminate. Each table surfaces are available, including rubber and operating device. comes with locking castors and remote handheld to provide a power All heated tables come with power sockets controller to source for other equipment, and a digital heater control the table surface temperature. Table Animal Operating Large OPERATING TABLE & THORACIC & POSITIONERS TABLE OPERATING

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EQUIPMENT 68 Large AnimalOperating Tables 75 to100cm(29 (31 to41 in).The flat-toptableheightmaybeadjustedfrom The V-Toptableheightmaybeadjustedfrom79 to104cm position. on areleasebarcausesthetabletoptoglidedownlowest action onarubberpedalsmoothlyliftsthetabletop.Pressingdown of thetabletoptoacomfortableheightandposition.Pumping operated, bothupanddown,allowingquickeasyadjustment The liftmechanismofthehydraulic-liftbaseiscompletelyfoot- Hydraulic-Lift Base along theedgeoftable. tie-down attachmentsoneachsidecanbelockedatanyposition for acollectingpailwhichisofferedasanaccessory.Twosliding trough aroundtableedges.Thedrainoutletontheendhasahook The tablecenterisslightlyelevatedsothatfluidsdraintoashallow rounded corners,resultinginnowelding,seamsorsharpedges. is die-formedfromonepieceofheavy-gaugestainlesssteelwith The extralarge152.5 x56cm(6022in)Flat-Top OperatingTable Flat-Top the tableslidealongedgeandlockatanyposition. offered asanaccessory.Twotie-downattachmentsoneachsideof to collectfluids.Thetablehasahookforcollectingpailwhichis A 76.2 mm(3in)troughcenteredunderthepanelscanbeused positioning withoutathoracicpositioner. adjusts independentlyfromhorizontaltonearverticalforexact The V-TopOperatingTableis147.5 x48cm(5819in).Eachpanel V-Top steel toprovidealifetimeofservice. of heavy-gauge,satinfinish,type 304,non-corrosivestainless stability andincludeslevelingscrews. Thebasecoverismade To order call Hydraulic-Lift Base Single Tiltingand Operating Tablewith Non-Heated Flat-Top ST1 59-6823 • with anycombinationofthebelowfeatures: animals upto136.2kg(300lb)andareavailable These sturdyoperatingtablesareforusewith – Heatedornon-heatedtop – Tiltingmechanism – Pedestalorhydraulic-liftbase – V-toporflat-top

1-508-893-8999 1 ⁄ 2 to39 1 ⁄ 2 in).Theheavybaseprovidesreal email [email protected] base iscoveredwithheavygauge,non-corrosivestainlesssteel. 94 cm(37 in);withaflat-toptable,itis 89 cm(35 in).Thepedestal The workingheightofthepedestalbasewithaV-TopTableis the worksurface.Fouradjustablescrewsfacilitateeasyleveling. yet innowayinterfereswithyourlegsandfeetasyoumovearound This baseprovidesasturdy,stablesupportfortheworkingsurface, Pedestal Base Accessories listed, CSAapprovedandCEmarked. 38 x122cm(1548in)ontheflat-toptables.ThesetablesareUL v-top tables,20x122cm(848in)foreachpanel,andmeasures The totalheatingareameasures40.5x122cm(1648in)onthe control boxwhicheasilymountsonatie-down/restraintrod. The temperaturecanbeadjustedfrom21°to42°C withtheheating Heated coilslocatedunderthetableprovideevenheatdistribution. surgery andareavailableforbothv-topflat-toptables. The heatedtabletopsaidinthepreventionofheatlossduring Heated Tops lock atanyangle. revolve 360°andtiltlengthwisefromhorizontaltonearvertical These operatingtablesofferaoneendtiltmechanism.Allwill Tilting Mechanism ST1 59-6830 Order # Non-Heated Heated 230VAC,50Hz Heated 115VAC,60Hz Flat-Top Non-Heated Heated 230VAC,50Hz Heated 115VAC,60Hz V-Top Table Style ST1 59-9524 Pedestal Base Table withSingleTiltingand Heated V-TopOperating ST1 59-6833

Collecting Pail,11.9liter(12 Product casters areequipped withlocks easily toexistinglevelingscrewsinthe Tablebase;allfour Surgery Tables;twoheavy-dutyplated steelcasterbarsattach Table CaddyaddsmobilitytoHydraulic LiftandPedestalBase with a20cm(7 noncorrosive stainlesssteelconstruction; 25.4cm(10in)deep web www.harvardapparatus.com ST1 59-6823 ST1 59-6836 ST1 59-6832 ST1 59-6822 ST1 59-6835 ST1 59-6831 Single Tilting Hydraulic-Lift Base OPERATING TABLES 7 ⁄ 8 in) diameter base in)diameterbase 1 ⁄ 2 qt) capacity; seamless, qt)capacity;seamless, ST1 59-6825 ST1 59-6838 ST1 59-6834 ST1 59-6824 ST1 59-6837 ST1 59-6833 Single Tilting Pedestal Base

69 SURGICAL EQUIPMENT

www.harvardapparatus.com web 29 x 20 x 20 cm (11.5 x 8 x 8 in) 29 x 20 x 20 cm (11.5 x 8 x 5 in (±0.25 in) 1.75 3.0 kg (6.7 lbs) 4.2 kg (9.3 lbs) 38°C or 42°C 10°C, 35°C, ± 1°C 34 L (9 gal)/hr oz) ml (93 2,750 SJT3), Hospital120 VAC, 60 Hz, 3.1 Amps, (18/3 grade plug, 20 A typical leakage current Product Disposable Polymer/Fabric Temperature Therapy Pad with Clik-Tite® Connectors, 7.6 x 58.4 cm (3 x 23 in), pkg. of 10 Disposable Polymer/Fabric Temperature Therapy Pad with cm (13 x 18 in), pkg. of 20 Clik-Tite® Connectors, 33 x 45.7 Disposable Polymer/Fabric Temperature Therapy Pad with cm (13 x 18 in), pkg. of 10 Colder Connectors, 33 x 45.7 Disposable Polymer/Fabric Temperatur Therapy Pad with cm (15 x 22 in), pkg. of 20 Clik-Tite® Connectors, 38.1 x 55.9 Disposable Polymer/Fabric Temperature Therapy Pad with cm (15 x 22 in), pkg. of 10 Colder Connectors, 38.1 x 55.9 Disposable Polymer/Fabric Temperature Therapy Pad with in), pkg. of 10 x 66 cm (18 x 26 Clik-Tite® Connectors, 45.7 Disposable Polymer/Fabric Temperature Therapy Pad with in), pkg. of 10 x 66 cm (18 x 26 Colder Connectors, 45.7 Reusable Heavy Duty Pliable All Polymer Pad with cm (15 x 22 in), pkg. of 1 Clik-Tite® Connectors, 38.1 x 55.9 Product oneHeat Therapy Pump with Clik-Tite® Connectors with 38.1 x 55.9 cm (15 x 22 in) pad, 120 VAC, 60 Hz cm (15 x 22 in) 38.1 x 55.9 VAC, 60 Hz Heat Therapy Pump with Clik-Tite® Connectors, 120 Heat Therapy Pump with Clik-Tite® Connectors, Hz 220 VAC, 50 VAC, 60 Hz Heat Therapy Pump with Colder Connectors, 120 Heat Therapy Pump Stand with 5 Casters and Basket Unit, H x W x D Handle, H x W Empty Filled # Order ST1 60-3414 ST1 60-3415 ST1 72-2582 ST1 60-3416 ST1 72-2583 ST1 60-3417 ST1 72-2584 ST1 60-3420 # Order ST1 72-9715 Specifications Dimensions: Weight: Temperature Settings Accuracy Flow Rate Capacity Power ST1 72-9716 ST1 72-9711 ST1 72-9717 ST1 60-3425 Clik-Tite is a registered trademark of Medisearch. These Temperature Therapy Pads provide localized warming during These Temperature Therapy Pads provide after surgery. procedures, as well as maintaining body temperature The unit quickly warms up and reaches the desired warming the desired warming warms up and reaches The unit quickly of 22.2°C. ambient temperature 11 minutes from set point within and water upon adding ice is initiated immediately Cold therapy four mode. Select from and setting to Cooling to the reservoir For convenience, or 42°C. 38°C settings: 10°C, 35°C, temperature with water a translucent reservoir tap water and has the pump uses Only filling and monitoring of the water level. fill indicators for easy periodic cleaning is necessary.

[email protected] email 1-508-893-8999 To order call

Ideal for maintaining body heat after surgery Provides localized warming Both disposable and reusable pads available Option of warm or cold therapy 20 minutes, Timed temperature cycles can be set to 30 minutes or continuous Alarms to alert user to provide action Low maintenance changes Lock-out switch to prevent inadvertent setting

• • • • • • • • Pump Heat Therapy Temperature Therapy Pads Pads Therapy Temperature The Heat Therapy Pump provides effective warming and cooling The Heat Therapy Pump provides effective pads. This pump features temperature therapy via water circulating on an intuitive, easy selectable and accurate temperature settings assist in preventing to use LED control panel and is designed to surgery or in recovery core body heat loss and hypothermia during and cooling for heat stroke or fever. Pump Therapy Heat HEAT THERAPYPUMP HEAT

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EQUIPMENT 70 Options Components Included: Parameters Measured PC computer). probes toanexternal device(matrixprinterwith serialportor front panel“SEND”button)the temperature valuesfromallthe RS-232/USB communication port,allowssending(bypressinga current temperatureofalltheprobes atthesametime.Abuilt-in The TMP812RSmodeloffersa20 x4LCDdisplayforshowingthe front panelrotarycommuter. (probe) atatime.Selectthedesired channelviathe12-position The TMP812modeldisplaysthecurrenttemperatureofonechannel the temperaturevalueisreadfromfrontpaneldisplay. should bepluggedintothejackconnectorsonrearpanel,while (not suppliedwiththeinstrument;mustbeorderedseparately) probes, freelyinterchangeable.StandardYSItemperatureprobes 0.1 degrees.Thereisnodifferencebetweenchannelsortemperature in thedigitaldisplayoffrontpanelhasaresolution Springs (YSI)thermistorprobes.Theregisteredcurrentvalueshown probes simultaneously.TemperatureismeasuredbyusingYellow system isdesignedforworkingwithupto12resistive-temperature measurement ofanimalbodytemperatureusingrectalprobes.The The TMP812isamulti-channeldigitalthermometersuitableforthe Key Features for Evaluating BodyTemperature D16 DigitalThermometer To order call Digital Thermometer • • • • • • • • • • • Temperature probes 2 yearwarranty Set oftwosparefuses Cables, connectors Instruction manual SeDaCom Software(onlyTMP12RS) communications port) Control unit(TMP12RSincludesRS-232 (TMP812RS) Recordings byeachuser-definedintervaloftime Current bodytemperature(degrees) Data transfertoPCorprinter Precalibrated andinterchangeableprobes 1-508-893-8999

email [email protected] 8. 7. 6. 5. 4. 3. 2. 1. References: * Note:RequiresST176-0608 Adapter. RS-232/USB SeDaCom application. user-selected timeintervalsprogrammeddirectlyfromthe separately, allowsthetransferofcurrentdatatoPCat Additionally, theWindows-basedprogramSeDaCom,purchased ST1 76-0608 ST1 76-0406* ST1 76-0069 ST1 76-0068 ST1 76-0067 ST1 76-0066 Options ST1 76-0065 ST1 76-0064 Order # Communications Capacity Resolution Specifications 108(3):755-66. (rat, Spain). (rat, 108(3):755-66. Neurochem. J. rat. the in deficits 5-HT 3,4-methylenedioxymethamphetamine-induced prevent inhibitors 5 Phosphodiesterase (2009) al. et E Puerta of Pharmacology. 62(3):198-207 (Rat, Spain). 62(3):198-207(Rat, Pharmacology. of Journal European rats in depletion serotonin 3,4-methylenedioxymethamphetamine-induced of enhancement amiloride underlying mechanisms the on (2007)Studies al. et B Goñi-Allo Metab. In press (mice, Denmark, Spain). Denmark, (mice, press In Metab. Endocrinol. Physiol. J. Am. mice. in hepatosteatosis and resistance insulin obesity, induced diet- reduces gene protein retinoblastoma the of Haploinsufficiency (2009) al. et J Mercader Neurochem, 104(4):914-25. (Rat, Spain). (Rat, 104(4):914-25. Neurochem, J ERK. and Akt channels, potassium ATP-sensitive mitochondrial of role depletions: serotonin 3,4-methylenedioxymethamphetamine-induced prevents Minoxidil (2008) al. et B Goñi-Allo (mice, Spain). (mice, 727-73349(9): Mutagenesis. Molecular and Environmental E-5842. compound antipsychotic the of administration after mice knockout receptor sigma-1 in formation micronuclei increased with associated conditions hypothermic of Induction (2008) al. et A Guzman Spain). (mice, 112(1):115-121 Ethnopharmacology of Journal mice in test swimming forced the in extracts fil. L. reflexum Hypericum some of activity (2007)Antidepressant al. et CC Sanchez-Mateo neurotoxic damage in rodents. Neuropharmacology. 54(8):1254-63. (rat, mice, Spain). mice, (rat, 54(8):1254-63. Neuropharmacology. rodents. in damage neurotoxic derivatives-induced amphetamine against protects Memantine (2008) al. et C Chipana Research/Genetic Toxicology and Environmental Mutagenesis, 656(1-2): 8-13 (mice, Spain). (mice, 8-13 656(1-2): Mutagenesis, Environmental and Toxicology Research/Genetic Mutation erythropoiesis, of stimulation with associated not is hypothermia of conditions under bone-marrow mouse in erythrocytes micronucleated of Formation (2008) al. et A Guzman - - YS409 YS451 YS402 YS401 TMP812RS TMP812 Model web www.harvardapparatus.com RS-232 (USB) RS-232 (USB) 12 temperatureprobessimultaneously 0.1°C SeDaCom Accessory-RS-232/USB Adapter to acomputer SeDaCom Software(2.0)fordatatransfer Surface TemperatureProbe(discdia.9.5mm) Temperature ProbeforMice(1.3mm) Temperature ProbeforRats&Mice(3mm) Temperature ProbeforRabbits(4.2 mm) temperature display,noprobesincluded 12 ChannelDigitalThermometer,multiple temperature display,noprobesincluded 12 ChannelDigitalThermometer,single Product THERMOMETERS

71 SURGICAL EQUIPMENT

www.harvardapparatus.com Product Scanner for 15 Probes Scanner for 30 Probes Pyrogen Test Software mm) Temperature Probe for Rabbits (4.2 Extension for PROBOX30 up to 60 Rabbits GLP Compliance Software Temperco Software Module for Humidity and Temperature Readings (2 Units Kimo TH200 Probes Included) Temperco Software Module for Weight Readings from either Mettler Toledo or Sartorius Scales Temperco Software Module for Free Modification of Supplied Phamacopoeias web 2.2 GHz Processor (Celeron processor excluded), 2.2 GHz Processor (Celeron processor excluded), 2 GByte of RAM, 1 free USB port for the License key (or second serial port available and 1 free RS-232 USB port) for the probes boxes connection. Windows™ XP (SP2 or higher) and Vista 32 compatible operating systems Model PROBOX15 PROBOX30 TEMPERCO YS401 PROBOX30E TEMPERCOGLP TEMPERCOHT TEMPERCOBAL TEMPERCOEF

# Order ST1 76-0295 ST1 76-0296 ST1 76-0298 ST1 76-0066 Options ST1 76-0297 ST1 76-0408 ST1 76-0300 ST1 76-0302 ST1 76-0407 Specifications Computer Requirements System Requirements Microsoft and Microsoft Excel are registered trademarks of Microsoft Corp. Windows is a trademark of Microsoft Corp. TEMPERCO is a complete system based on carefully developed based on carefully developed is a complete system TEMPERCO It is a compatible computers. hardware for PC or software and according out the Pyrogen test cost tool that carries powerful low up to 90 animals simultaneously. with to several Pharmacopoeias with total interchangeability uses pre calibrated probes, The system is a software flexibility. The TEMPERCO-associated and a high the simultaneous use of big groups of powerful tool which allows in all the different phases of the animals providing temperature and converting them to the US, Korean, test, analyzing the results Alternatively, customers may modify most European Pharmacopeia. of the given pharmacopoeias thanks to of the parameters of any the TempercoEF module. provides complete information During the test, the software such as temperatures higher than a of every detected incident, events are warned in the program with specified value. All these message giving the experimenter the the corresponding window correct action depending on the situation. possibility to decide the the experimenter a final At the end of the test, TEMPERCO provides including the selected list resuming the information of each group, lists can be exported Pharmacopoeia application evaluation. These that allows archiving in Microsoft® Excel® format and/or in a format information is stored it like an official document. In addition, the it whenever the optionally in the hard disk which allows consulting user needs it.

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email 1-508-893-8999 To order call Interchangeable and pre-calibrated temperature probes Interchangeable and pre-calibrated temperature Automatic temperature readings GLP compliance software module Available Pharmacopoeias (editable): CFR21, Chinese, Korean, European, Indian USP24, available High and low temperature threshold alarms individual weight Automatic dose estimation according to Registry of initial and test temperature for Graphic form of the initial and test temperatures user-defined probes or groups on the Temperature increase calculated depending Group status at the end of the inoculation process (free, contaminated or to be repeated) Connection box Instruction manual Cables, connectors 2 year warranty Set of two spare fuses Calibration certificate Temperature probes Pyrogen test software (TEMPERCO) GLP compliance software module • • • • • • • • • pharmacopoeia chosen • • • • • • • • • • Carrying out the - For TEMPERCO in Rabbits Test Pyrogen Key Features PYROGEN TESTER PYROGEN Parameters Measured Components Included: Options

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EQUIPMENT 72 page 77. probes arenotincluded,seepages 78-81. ForMicroprobes,see that canbewornlikeacamera, leaving thehandsfree.Temperature sealed construction.Itissuppliedwithaheavy-dutycarryingcase waterproof, dustproof,andfume-proofbecauseofitssturdy, This PortableThermocoupleThermometeriscompletely warnings indicatelowbatteryorfaultyprobe. It willoperatefor120hourswithasingle9voltbattery.Automatic rechargeable NiCadbatteriesandanintegralbatterycharger. transistor battery,orforACpowerwithbatteryoperationusing This thermometerisavailableforusewitheitheradisposable9 volt temperature andisCEmarked. surface temperatures,liquids,andsolidsaswellanybiological This accuratedigitalThermo­ Portable Thermocouple Thermometer To order call with TemperatureProbe(notincluded) Portable ThermocoupleThermometer •  have traceableaccuracytoNISTstandards. pages. Norecalibrationisrequired.Allofthethermometers the ThermocoupleThermometersdescribedonfollowing Probes. Theseprobescanbeusedinterchangeablywithallof measurements. We offer a wide range of "T" type Thermocouple temperature probesforaccurate,precise Harvard Apparatusoffersarangeofthermometersand • • temperaturefrom0°to50°C • • 0.1%±1digitoverfullrange • two, threeorfiveprobeinput,seenextpage. resolution andaccuracyof0.1°Careavailablewithone, The ThermocoupleMonitoringThermometershavea see pages77and81. Microprobes tomeetalltemperatureneeds, Choose fromavarietyofinterchangeableProbesand Analog outputforstripchartrecorders Auto-correction featurecompensatesforambient Fast readingsto0.1°C(usuallyin25seconds) Superior accuracy:0.1°C±1digitinphysiologicalrange, 1-508-893-8999 couple Thermometercanmeasure email [email protected] •  •  Weight Dimensions, HxWD Battery Analog Output Input Socket Sensor Display Compensation Ambient Temperature Calibration (Instrument Only) Accuracy Resolution Temperature Range Specifications ST1 52-1310 ST1 72-7564 ST1 52-1781 ST1 52-1773 ST1 59-7568 ST1 59-7567 ST1 52-1302 Order # see page75 and76. and canbeusedwithalloftheThermocoupleThermometers, an animal’stemperatureduringthermallysensitiveprocedures The TCAT-2TemperatureControllerpermitsaccuratecontrolof accuracy of0.1°C,seebelow. temperature rangefrom-100°to+200°Candaresolution The PortableThermocoupleThermometerhasawide THERMOMETERS &PROBES (Thermocouple Monitoring Thermometers) (Thermocouple MonitoringThermometers) (Portable ThermocoupleThermometer) omnidirectional swivel.Itprovidesforeasypositioningofthe Tilt Base,black,heavymetalBasehasalockingtiltheadand Extension CableforMiniatureTypeTTemperatureProbes Five-Way ProbeSelector,seenextpage Two-Way ProbeSelector,seenextpage Rechargeable Batteries,230VAC,50Hz Portable ThermocoupleThermometerforACor Rechargeable Batteries,115VAC,60Hz Portable ThermocoupleThermometerforACor with 9VDisposableBatteries Portable ThermocoupleThermometer Product web www.harvardapparatus.com 0.9 kg(2lb)includingcarryingcase x6in) 12.7 x6.415.2cm(52½ 9 Vtransistor Approximately 10mV/°C Miniature “T”,quickdisconnect,copper-constant Type “T”Thermocouple,copper-constant digits,13mm(½in)high LCD, 3½ 0° to50°C Auto-corrected to0.1°C Conforms toNBSthermocoupletableswithin1digit 0.1°C ±1digitbetween0°to50°C 0.1°C ofreading±1digit -100° to+200°C

73 SURGICAL EQUIPMENT

digits, 18 mm 2 ⁄ lb) 1 4 ⁄ 1 Probe Three -10° to +60°C 0.1°C 0.1°C ±1 digit at 25°C ambient 3 (0.7 in) high displays °C 4 “C” cell batteries 2,000 hrs continuous LO-BAT appears display when battery voltage is low but several hours of life remain INPUT appears on display x 1 in) 8 ⁄ 3 in) 2 ⁄

1

A at 60 Hz; the instrument is isolatedA at 60 Hz; the www.harvardapparatus.com web digits, 12.7 mm ( in) and weighs 0.6 kg (1 2 ⁄ 3 ⁄ 1 1 Conforms to National Institute of Standards and National Institute of Standards Conforms to tables. Monograph 125 Technology < than 10 µ to and from mounting supports from ground ground is volts; capacitance to withstand 5000 surgical compatibility with electro low to ensure equipment Inhalation AnestheticsConforms to: NFPA #56A, Current Limits for ANSI/AAMI Safe UL #544, 1972 Electronics Apparatus Type “T” thermocouple, copper-constant copper-constant Miniature “T” quick disconnect, Single Probe 25° to 45°C 0.1°C 0.1°C ±1 digit 3 high numerical display only 4 “C” cell batteries 1,200 hrs continuous Automatic 2-stage warning indicator flahes when 8 hours of life remain; becomes continuous when batteries must be replaced Display reads “0” x 6 x 6 4 ⁄ 1 Extension Cable for Miniature Type T Temperature Probes Tilt Base, black, heavy metal Base has a locking tilt head and omnidirectional swivel. It provides for easy positioning of the (Portable Thermocouple Thermometer) (Thermocouple Monitoring Thermometers) (2 Five-Way Probe Selector, accepts up to five Temperature Probes. A single connector goes to any of the Thermocouples 16 cmThermometers. It measures, H x W x D, 7 x 15.2 x Product Single Probe Thermocouple Monitoring Thermometer Three Probe Thermocouple Monitoring Thermometer monitored Two-Way Probe Selector, Permits two probes to be the probewith one Thermometer. This small unit plugs into input on any of the Thermocouple Thermometers. It measures,input on any of the Thermocouple Thermometers. H x W x D, 2.5 x 3.5 x 2.5 cm (1 x 1 ST1 72-7564 ST1 52-1310 ST1 52-1781 # Order ST1 60-1956 ST1 59-7569 ST1 52-1773 Specifications Calibration Leakage Currents Safety Standards Sensor(s) Input Socket(s) Monitoring Thermometer Temperature Range Resolution Accuracy (Instrument Only) LCD Display Power Supply Battery Life Battery Warnings Faulty Probe or Input [email protected] email ST1 52-1773 Two-Way ProbeST1 52-1773 Selector ST1 52-1310 Tilt Base ST1 52-1310

1-508-893-8999

To order call Choice of one, two, three or five probe inputs mometers monitor these probes three times per second for • ST1 59-7569 Three ST1 59-7569 Probe Thermocouple Monitoring Thermometer ST1 60-1956 Single Probe Thermo-coupleST1 60-1956 Monitoring Thermometer ST1 52-1781 Five-Way Probe Selector ST1 52-1781 These thermometers are for use with the Thermocouple Probes These thermometers are for use with the Thermocouple The and Microprobes, see page 77. offered on pages 78-81, ther­ fast response to temperature changes. Two models of this thermometer are available: a single probe input or three probe input. Both are powered by four “C” cell batteries (supplied) and have an analog output jack and mating connector for connection to a chart recorder. The cable is not supplied. The Single Probe Thermometer has a temperature range from readable in 0.1°C increments. It reads temperatures in 25° to 45°C Celsius only. The Three Probe Thermometer displays the temperature reading in either Celsius or Fahrenheit. It has a temperature range from -10° to +60°C (14° to 140°F) readable in 0.1°C (0.1°F) increments. Push buttons on the front of the Thermometer are used to select which probe temperature is displayed. A Two-Way or Five-Way probe selector is available for use with any of the Thermocouple thermometers. Thermometers Monitoring Thermocouple THERMOMETERS

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EQUIPMENT 74 different loads. for heatingpads.Thisversionallows youtocontrolavarietyof powered warmingblanketsand a low-voltage,lownoiseDCoutput for controllingprimarilyresistance loadssuchasheat-lamps,AC This isacombinationversionwhich includesbothanACoutlet TCAT-2DF Controller of DCpowersuppliesdependingontheloadrequirements. faulty feedbacksensor.Onacustombasis,wecanprovidevariety feature inpreventingburnsduetoincorrectcontrolsettingsor point duetothermallaginthecontrolsystem.Thisisanimportant circuit topreventaheatingelementfromovershootingthecontrol for smallrodents.TheTCAT-2LVutilizesadualsetpointcontrol power supplydesignedtooperatewithourHP-1MHeatingPlate other monitoringdevices.ItcomesstandardwithabuiltinDC sensitive applicationswhereACfrequenciesmightinterferewith This modelprovidesalowvoltageDCoutputforelectrically TCAT-2LV Controller such asaheatlamp.Itistheleastcostly. This versioncontrolsonlyACpoweredheatingorcoolingdevices TCAT-2AC Controller See belowformodeldescriptions. Controller. Whichmodelyouselectdependsonyourapplication. applications arediverse,weprovideseveralversionsoftheTCAT independent perfusatecoolingsystems.Realizingthatlaboratory TCAT-2 mayalsobeusedincoolingapplications,suchastocontrol Small animalcagesareeasilywarmedwithaheatlamp.The anesthetized animalsduringsurgeryorstereotaxicprocedures. TCAT-2 maybeusedtomaintainthebodytemperatureof applications. Combinedwithaheatlamporheatingpad,the provides accuratetemperaturecontrolinavarietyoflaboratory Our TCAT-2familyofgeneralpurposePIDautotuningcontrollers TCAT-2 Temperature Controller To order call • • • • • Resolution 0.1°C Control Rangeof-100°to+400°C 110 to230VAClineoperation Use forbothheatingandcoolingapplications Controls heatlampsorheatingplate 1-508-893-8999 email [email protected] unit isswitchedoff. the instrument.Thesettemperatureisstoredinmemoryafter (lower greendisplay)accordingtotheinstructionlabelontopof the rearofcontroller.Adjustsettemperatureasrequired pad, blanket,lamporcoolingdevicetotheappropriateoutleton the animalandtobackofcontroller,connectheating The TCAT-2issimpletoset-up;connectthefeedbacksensor being appliedtotheload. small lamponthefrontofcontrolunitindicateswhenpoweris load whenfeedbacksensortemperaturefallsbelowthesetpoint.A In thecoolingmodeitinvertscontrolfunctionandshutsoff such assmallrefrigerationcompressorsorthermoelectricstages. switch isprovidedwhenusingthecontrollerwithcoolingdevices controller toprovideamoreconvenientviewingangle.Aheat/cool housing. Adjustablefrontfeetallowtheusertoraiseof The unitcomesinadurable,bakedenamelpaintedaluminum are designedtooperateona110VACor230supply. also beuseddependingonthespecificapplication.Allinstruments probes, buttheimplantableflexibleprobesandneedlemay temperature feedbacksensor.Mostcommonlyusedaretherectal line ofthermocoupleprobes,seepages77-81,whichactasthe All TCAT-2versionsmaybeusedwithanyofourextensive Probes ST1 72-7561 ST1 72-7560 ST1 72-7559 Order # Dimensions, HxWD Protection Feature Dual Setpoint Current AC GroundLeakage DC OutputRating Max ACPowerOutput Readout Range Resolution Accuracy Specifications Power Supply Weight TEMPERATURE CONTROLLERS Plates, see next page. next see Plates, and Lamp Heat For TCAT-2DF TemperatureControllerforBoth TCAT-2LV TemperatureControllerforPlate TCAT-2AC TemperatureControllerforLamp Product web www.harvardapparatus.com 11.1 x18.425.4cm(4 temperature exceeding40°C Additional heatingpadfeedbacksensorprevents TCAT-2DF andTCAT-2LVonly < 1mAat110VAC (Does notapplytoTCAT-2AC) 12V DC,2AmpsMaximum Resistive Load 700 watts(DoesnotapplytoTCAT-2LV)with temperatures Dual displayofSet(green)andRun(red) -100° to+400°C ±0.1°C ±0.5°C 110 VACor220VAC,50/60 Hz < 2.27 kg(<5lbs) 1 ⁄ 3 x7

1 ⁄ 4 x10in)

75 SURGICAL EQUIPMENT x 8.5 in) 8 ⁄ 3 RTD 3.8 x 10.2 cm (1.5 x 4 in) cm (0.25 in) 0.65 25 W DC 100 Ω 11.1 x 21.6 cm (4 www.harvardapparatus.com web Product Heating Plate, Large* Heating Plate, Small* Product Portable Digital Thermometer including Probe Replacement Temperature Probe, 1.6 mm OD Ideal for small rodents Works with K-type thermocouple probes Available in two sizes Small Large • • • Specifications Dimensions, W x L: Height Above Surface Power Over Temperature Protection # Order ST1 72-7563 ST1 72-7617 # Order ST1 34-1401 ST1 34-1402 Temperature monitoring is essential especially in small rodents. This portable, rugged Digital Thermometer is perfect for rectal temperature measurement of any rodent from mice upwards. This thermometer can measure in Celsius, Fahrenheit, or Kelvin with an accuracy to 0.1° Celsius. It comes with backlight for dark environments as well as one 3.0 mm OD and one 1.6 mm OD probes. Digital Thermometer Portable *Note: Requires the TCAT-2 Controllers, see page 75. TCAT-2 for Plates Heating for the TCAT-2 These Heating Plates are an optional accessory heating plates for Temperature Controller. They are direct current available to suit your small rodents (mice and rats). Two sizes are application. aluminum and The Heating Plates are made of black anodized mm (0.25 in) above the have small feet giving it an elevation of 6.4 stage. surface it sits on, such as a table or stereotaxic Plates have a It is easily cleaned with alcohol. These Heating TCAT-2 our with used when overheating prevent to sensor feedback series of controllers on page 75. [email protected] email TCAT-2 Temperature Controller TCAT-2 Temperature 2 Spring loaded arms each 45.7 cm (18 in) lengths cm (18 2 Spring loaded arms each 45.7 upStandard “U” screw clamp expands to fit bench to 5.7 cm (2.25 in) deep 0.91 kg (2 lbs) 110 VAC, 60 Hz 250 W infrared heat lamp 1-508-893-8999 Product Heat Lamp HL-1 To order call Ideal for use with mice and rats Easy to use with TCAT-2 models • • ST1 72-7562 Table Clamp Weight Power Bulb # Order Specifications Arm Length This infrared heat lamp is table mounted with an adjustable swing This infrared heat lamp is table mounted with heat to specimen. The arm providing for easy adjustment of radiant heat lamp bulb and a lamp is supplied with a 250 Watt (infrared) provided and easily built in reflector. A chrome bulb guard is also is installed. This Heat snaps onto the lamp housing after the bulb can plug directly into Lamps fits a standard 110 VAC socket, so it controllers the wall or it can be used with one of the temperature on page 75. Lamp HL-1 Heat HEAT LAMP, HEATING PLATES & THERMOMETER & PLATES HEATING LAMP, HEAT

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EQUIPMENT 76 (except ST152-1716). semi-solids andtissuewithneedle(supplied)arequiterugged for specialapplicationsaswell.Theseprobesareimplantablein in neonatalmice,waterbaths,etc.Customprobesareavailable muscle tissue,bloodvessels,spectrophotometercuvettes,rectally These fastresponseprobesareusedforimplantationinbrainand An extensiverangeofflexiblePTFEmicroprobesarenowavailable. Microprobes Gluteraldehyde solutionorautoclave. maximum temperatureof140°C. ItmaybesterilizedbyGas(EtO), 0.032 in(maxattip0.04inch).Timeconstant0.18 secondswitha inset). Itmeasures36inlongand hasanoutsidediameternominal has aflexiblepolyurethanesheath withsmoothroundedtip(see This MicroRectalProbeforverysmallanimals(neonatalmice), it and OtherVery SmallAnimals Micro Rectal Probe For Neonatal Mice ST1 72-7616 Order # To order call Microprobes Micro RectalProbe • • • • Smalldiameter0.23mm(0.009inches) • Idealfor: Can besterilizedbyautoclaving,gas(EtO)orCidex Flexible microprobesthatarecompletelysealed Fast -Timeconstantof0.005seconds – Insertionintobloodvessels – Implantationinbrainormuscletissue – Rectalmeasurementsinneonatalmice 1-508-893-8999 RET-4 RectalProbe forVerySmallAnimals Product email Micro RectalProbe [email protected]

can besterilizationbyGas(EtO). 0.004 seconds.Themaximumtemperature forthisprobeis70°C. It on 1indiameterprotectivespool asshown.Ithasatimeconstant The probeissuppliedinastandard lengthof36in.Itissupplied 0.009 in. insulated tiphasamaximumoutsidediameter responding. Thewirecrosssectionmeasures0.005x.0025 in.The brains andothertissue.Thisprobeisfairlyfragile,butveryfast is idealforresearchapplicationstomeasuretemperatureinanimal Thermometer, seepages73 and74 respectively. or theST160-1956 SingleProbeThermocoupleMonitoring such astheST152-1302 PortableThermocoupleThermometer are completelyinterchangeableinanythermocouplethermometer, physiological range.Probesdonotrequireindividualcalibrationand thermocouple wireandareguaranteedaccurateto0.1°Cwithinthe All microprobesaremadewiththeproprietarycopper 52-1732. response ofST152-1716, buthasthePTFEsheathstrengthofST1 microprobe sensorbeadisexposed,thus,itcombinestheultra-fast seconds (thisST152-1716 microprobeisratherfragile).ST152-1757 results infastresponsetimeswithtimeconstantsaslow0.005 as 0.229mm(0.009inch)diameter.Theextremelysmallmass Our flexiblemicroprobesareavailablewithasensorleadassmall They canbeautoclavedorsterilizedbyuseofgas(EtO)Cidex. sealed andcanbeusedtomeasuretemperaturesup150°C. These fastreadingmicroprobesarestrong,flexible,completely ST1 52-1757 ST1 52-1716 ST1 52-1740 ST1 52-1732 ST1 52-1724 Order # ST1 72-7567 Order # Flexible Microprobe Ultra FineIT-Series Ultra FineITSeries FlexibleMicroprobe Product THERMOCOUPLE PROBES IT-1E IT-23 IT-21 IT-18 IT-14 Type Probe web 18 23 21 18 14 Gauge Needle www.harvardapparatus.com (0.025 in) 0.635 mm (0.009 in) 0.229 0mm (0.016 in) 0.406 mm (0.025 in) 0.635 mm (0.050 in) 1.27 mm Diameter insulated thermocouplebead.It coated wirewithpolyester is a32 gaugepolyurethane This temperatureMicroprobe Flexible Microprobe Ultra FineIT-Series • 0.005 second 0.005 second 0.08 second 0.1 second 0.3 second Constant Time 32 gaugeprobe 0.91 m(3ft) 0.91 m(3ft 0.304 m(1ft) 0.91 m(3ft) 0.91 m(3ft) Length Lead

77 SURGICAL EQUIPMENT

in) 4 ⁄ 3 in) long tubular Shaft, D x L 0.71 x 19.1 mm x (0.025 1.5 x 25.4 mm x 1 in) (0.059 2 ⁄ 1 Ball Diameter mm1.65 in) (0.065 3.18 mm (0.125 in) www.harvardapparatus.com

web Time Constant 0.5 sec 0.8 sec in) diameter x 140 mm (5 8 ⁄ 1 Product Micro Probe (C) Animal Mice (A) Rats (B) in) long stainless steel shaft to facilitate temperature in) long stainless steel shaft to facilitate temperature 2 ⁄ 1 Time constant second 0.025 • These Thermocouple Probes are made with proprietary copper made with proprietary Probes are These Thermocouple stringent to 0.1°C due to wires and are accurate thermocouple fast the sensor provides The small size of wire standards. seconds. as low as 0.005 with time constants response times be used interchangeably Probes can These Thermocouples Thermometers described on the with all the Thermocouple recalibration is required. These probes can preceding pages. No or Cidex. be sterilized by gas (EtO) # Order ST1 52-1765 # Order ST1 52-1591 ST1 52-1583 (C) Probe Micro This probe is for use on micro-specimens. The sensor bead slightly protrudes from the in) diameter x 0.33 mm (0.013 12.7 mm ( Rectal Steel Stainless (A, B) Probes For fast intermittent and rats. measurements in mice steel shaft They have a stainless Maximum with a 1.5 m (5 ft) lead. temperature 125°C. Not isolated. Available with two different shaft sizes. Supplied individually. handle fits most micromanipulators for precise positioning. The maximum intermittent temperature 200°C; continuous use 100°C . Not isolated. Supplied individually. Lead length 1.5 m (5 ft). probing. The 3.2 mm ( [email protected] email TCAT-2 Temperature Controller TCAT-2 Temperature 1-508-893-8999 (probes shown are not to scale)

To order call ST1 52-1591 Rectal Probe for Mice Stainless Steel ST1 52-1575 Surface Probe ST1 52-1732 Flexible Implantable Probe ST1 52-1609 Fast Response Needle Micro-Probe Stainless Steel Rectal Probe for Rats Stainless Steel Rectal Probe ST1 52-1583 ST1 52-1765 Micro-Probe Micro-Implantable Probe with PTFE Sheath ST1 52-1757 ST1 52-1716 Micro-Implantable Probe with PTFE Coating ST1 60-1960 Fast Response Sharp Needle Micro-Probe (G)  (H)  (I)  (F)  (E)  (D)  (C)  (B)  (A)  THERMOCOUPLE PROBES THERMOCOUPLE

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EQUIPMENT 78 individually. ft) lead.Maximumtemperature200°C.Notisolated.Supplied individually. in PTFE.Quiterugged.Maximumtemperature150°C.Supplied small animals.Theseelectricallyisolatedprobesaretotallysheathed also forimmersioninvarioussolutionsandrectalmeasurements in The 0.33mm(0.013 in)stainlesssteelshaftis9.5mm( ( with a90°bendthatis3.2mm( Supplied individually.Ratherfragile. bead exposed.Maximumtemperature150°C.0.9m(3ft)lead. 52-1732 FlexibleImplantableProbe,seebelow,butwiththesensor coating orwithaPTFEsheathforaddeddurabilitysimilartotheST1 (supplied). TheseprobesareavailablewitheitherathinPTFE on micro-sizespecimens.Theyaretissueimplantablewithaneedle These electricallyisolatedprobesareforultra-fastmeasurements Order # ST1 52-1740 ST1 52-1732 ST1 52-1575 Order # ST1 52-1724 1 ST1 52-1716 ST1 52-1757 Order # To order call ⁄ 8 1/8" in)diameterhandleis140mm(5 .009" Dia. 3/8" .009 Dia. 1/4" .013" Dia. ST1 52-1757 ST1 52-1716 1-508-893-8999 Constant Time 0.08 sec 0.1 sec(G) Surface Probe(D) Product 0.3 sec Micro-Implantable ProbewithPTFECoating(F) Micro-Implantable ProbewithPTFESheath(E) Product .025Dia. 5-1/2" 1/8" Dia. 1 Diameter Tip 0.41 mm(0.016 in) 0.64 mm(0.025 in) 1.3 mm(0.050in) ⁄ 8 in)long.The3.2mm a needle(supplied).Theyare in tissuesandsemi-solidswith These probesareimplantable Probes (G) Flexible Implantable arteries, etc.andfordentaluse. is forlocatinginflammation, This fastresponseSurfaceProbe Surface Probe (D) Micro-Implantable Probes (E,F) 1 email ⁄ 2 in)longwitha1.5m(5 • • • [email protected] 0.025 second Time constant 0.23 mm(0.009in) diameter only Sensor tipandlead 0.005 second Time constant Length Lead 0.3 m(1ft) 0.9 m(3ft) 0.9 m(3ft) 3 ⁄ 8 in)long

is 3.2mm( steel needleformaximumheattransfer.Maximuminsertiondepth gauge, 0.33mm(0.013 in)diameterby1cm(0.39 in)longstainless readings onverysmallspecimens.Sensorbeadisweldedtoa29 length 1.5m(5ft). individually. needle lengthswitha1.5m(5ft)lead.Notisolated.Supplied Maximum temperature200°C.Availableinthreegaugesofvarying probes. Forlongerlifeandeasierinsertion,usetheshorter the specimen.Forfastestreadings,usesmallerdiameter needle tipissealedtoensurethatonlystainlesssteelcontacts Order # Specifications ST1 52-1708 Blunt Tip ST1 52-1666 Sharp Tip ST1 52-1674 ST1 52-1633 ST1 52-1682 ST1 52-1609 ST1 52-1641 ST1 52-1690 ST1 52-1617 ST1 52-1658 ST1 52-1625 ST1 60-1960 Order # 1/8" Length Dia. 1 ⁄ 8 in).Maximumtemperature150°C.Notisolated.Lead Fast ResponseSharpNeedleMicro-Probe(I) Product THERMOCOUPLE PROBES Tip/Length Needle 1 cm 1 cm 2 cm 2 cm 3 cm 3 cm(H) 4 cm 5 cm 5 cm 6 cm 8 cm web www.harvardapparatus.com Constant Time 0.025 sec 0.025 sec 0.025 sec 0.1 sec 0.025 sec 0.15 sec 0.1 sec 0.025 sec 0.15 sec 0.1 sec 0.15 sec high accuracytemperature This needleprobeisforinstant, Needle MicroProbe (I) Fast Response Sharp and verysmallspecimens.The in tissue,semi-solids,liquids instant temperaturereadings These needleprobesarefor MicroProbes (H) Fast Response Needle • 0.025 second Time constant Diameter 29 G;0.33mm 29 G;0.33mm 29 G;0.33mm 26 G;0.46mm 29 G;0.33mm 23 G;0.64mm 26 G;0.46mm 29 G;0.33mm 23 G;0.64mm 26 G;0.46mm 23 G;0.64mm

79 SURGICAL EQUIPMENT

Liquids Corrosive Max. Temp. 150°C (302°F) ST1 52-1468 ST1 52-1476 ST1 52-1484 #304 stainless steel shaft for non-corrosive liquids PTFE-coated #304 stainless steel shaft for corrosive liquids Time constant Time constant 0.5 second Time constant 0.15 second • • • • (L) Immersion Probes General Rugged (J) Purpose Probes Purpose General (K) Probe www.harvardapparatus.com web Liquids Non-Corrosive Max. Temp. 400°C (752°F) (L) ST1 52-1435 ST1 52-1443 ST1 52-1450 Product General Purpose Probe (K) Product Probe, 7.6 cm (3 in) Shaft (J)Rugged General Purpose Probe, 22.9 cm (9 in) Shaft Rugged General Purpose 3/16" Dia. 304 S/S Welded Closed .059" Typ. 3" 4" # Order ST1 52-1393 # Order ST1 52-1401 ST1 52-1419 Shaft Length 30.5 cm (12 in) in) cm (24 61 91.4 cm (36 in) These liquid Immersion Probes have a welded shaft with wooden handle and 1.5 m (5 ft) lead. The non-corrosive liquid probes have a 2 second time constant and are not isolated. The corrosive liquid probes have a 3 second time constant and are isolated. Supplied individually. These heavy duty, immersible probes are for liquids, gases and These heavy duty, immersible for surface temperature measurements, see semi-solids. Not good Purpose Probe below. They have a stainless General ST1 50-1393 handle and 1.5 m (5 ft) lead. Maximum steel shaft with a plastic isolated. Supplied individually. temperature 400°C. Not This immersible Probe is ideal for surface temperature liquids and gases. measurements of solids; also for semi-solids, is bent at a right angle to the Probe shaft in) tip mm (0.02 The 0.51 The Probe has a 102 to facilitate accurate surface measurements. stainless steel shaft with a plastic handle and 1.5 in) welded mm (4 Not isolated. (464°F). m (5 ft) lead. Maximum temperature 240°C Supplied individually. [email protected] email 1-508-893-8999 (probes shown are not to scale)

To order call ST1 52-1427 Kapton Insulated Probe ST1 52-1518 Oral Probe ST1 52-1559 Skin Surface Probe with Plastic Handle ST1 52-1401 Purpose Probe Rugged General ST1 52-1526 Flexible Vinyl Rectal Probe ST1 52-1567 Esophageal Probe ST1 52-1542 Skin Surface Probe with Stainless Steel Handle ST1 52-1435 Immersion Probe for Non-Corrosive Liquid (Q)  (Q) (R)  (P)  (M)  (N)  (O)  (L)  (K) ST1 50-1393 General Purpose Probe (J)  THERMOCOUPLE PROBES THERMOCOUPLE

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EQUIPMENT 80 package of6Probes. to 450°C. Maximumtemperature400°C.Notisolated.Suppliedina The leadiscoveredwithtoughKaptonwhichagoodinsulatorup welded toaflexible,0.73 mm(0.029 in)diameter,1.5m(5ft)lead. This probeisformulti-pointmeasurements.Thesensorbead lead. Maximumtemperature90°C.Isolated.Suppliedindividually. tip ismountedona2.4mm( discomfort. The4mm( This probeisflexible,vinylcoveredandsoft-tippedtoalleviate temperature 400°C.Notisolated.Suppliedindividually. disconnect plugsandsocketsa3m(10ft)lead.Maximum supplied completewitha3.2mm( to fitinsideoroutsideanydiameterpipe.Theungroundedsensoris installation. The3.2mm( ST1 52-1427 Order # ST1 52-1534 ST1 52-1526 Order # ST1 52-7560 ST1 52-1492 Order # To order call Welded Closed 5/32"Max. 1/4" Max. 1/8" Dia. 1-508-893-8999 .029" Typ. 1/8" NPTFitting Kapton InsulatedProbe(M) Product Disposable Sheaths,pkg.of1,000 Flexible VinylRectalProbe(N) Product Permanent InstallationProbes,15.2cm(6in)Shaft Permanent InstallationProbes,30.5cm(12in)Shaft Product Quick-Disconnect 3/32" 5 ⁄ 32 1 ⁄ in)diameterby6.4mm( 8 in)diameterIconelshaftcanbeformed 3 ⁄ 32 in)diameterby1.5m(5ft)long 1 Kapton Insulated Probe (M) For rabbitsandlargeranimals. Probe (N) Flexible Vinyl Rectal These Probesareforpermanent Probes Permanent Installation ⁄ 8 email in)compressionfitting,quick • • • [email protected] 0.01 second Time constant 5 seconds Time constant 3 seconds Time constant 1 ⁄ 4 in)longprobe

etc. Ithasa4.8mm( of temperaturegradientsinenvironmentalchambers,freezerboxes, Temperature rangeisfrom-200°to+200°C.Suppliedindividually. stainless steelshaftwithawoodenhandleand1.5m(5ft)lead. ( disk is10Kt.goldforsuperiorconductivity.The2.4mm Supplied individually.Leadlength1.5m(5ft). 6.4 mm( This flexible,vinylcoveredprobehasa4mm( individually. 1.5 m(5ft)lead.Maximumtemperature 90°C.Isolated.Supplied isolated. Suppliedindividually. The balltipis2.4mm( (3 in)stainlesssteelshaftandhandlewitha1.5m(5ft)lead. This ball-tippedprobeisforfastoralreadings.Ithasa76 mm 3 ST1 52-1567 Order # ST1 52-1534 ST1 52-1518 Order # ST1 52-1500 Order # ST1 52-1559 ST1 52-1542 Order # ⁄ 32 1/4" 3/32" in)thickandistapedon.Maximumtemperature90°C. 3/32" Dia. 5/32"Max. 3" 24" 1-1/2" 1/4" Max. 1 3/16" Dia. ⁄ 4 in)longtipmountedona3.2mm ( ST1 52-1542 ST1 52-1559 Esophageal Probe(R) Product THERMOCOUPLE PROBES Disposable Sheaths,Pkg.of1,000 Oral Probe(O) Product Air andGasProbe Product Skin SurfaceProbeswithPlasticHandle;Isolated(Q) Not Isolated(P) Skin SurfaceProbeswithStainlessSteelHandle; Product .050"Dia. web 1.5" 3 1/4" Dia. 1/8" Dia. ⁄ www.harvardapparatus.com 16 3 in)diameterby610 mm(24 in)long#304 ⁄ 32 in).Maximumtemperature125°C.Not This probeisforinstantreadings ProbeAir andGas Oral Probe (O) ( The non-allergenic,6.4mm temperature measurements. Ideal forskinsurface (P, Q) Skin Surface Probes Esophageal Probe (R) 1 ⁄ 4 in)diametersensor • • • • 0.05 second Time constant 0.15 second Time constant 0.05 second Time constant 0.8 second Time constant 1 5 ⁄ 8 ⁄ 32 in)diameterby in)diameterby

81 SURGICAL EQUIPMENT

High precision handheld Convenient, with the thermometer accuracy of YSI Uses standard YSI 400 series probes Battery powered • • • • Precision Thermometer Precision ST1 61-0223 with Thermometer shown (not 400 series rectal probe included, see pages 83-84) www.harvardapparatus.com web inch phone jack 4 ⁄ 10 to 40°C; 0 to 85% RH 21 x 10.2 x 3.8 cm (8.25 x 4.0 x 1.5 in) ±0.115°C from 0 to 50°C -40 to +150°C 0.01°C 2 readings per second 4.5 digit LCD 20 hours typical (9V alkaline cell included) Flashing battery symbol when less than 5% of life remains °F or °C selectable from keypad 10 minutes with battery power communications and no RS-232 1 Product Precision Thermometer Cable RS-232 Carrying Case Tripod Battery Adaptor Operating Conditions Dimensions, H x W x D Specifications Accuracy Range Resolution Reading Rate Display Battery Life Battery Indicator Temperature Units Auto Shutoff Mating Connector # Order ST1 61-0223 ST1 61-0293 ST1 61-0294 ST1 61-0295 ST1 61-0296 Precision Thermometer Has NIST traceability. Features temperature readout in either °F Features temperature readout in either °F Has NIST traceability. menu selectable hold, min/max, DT and store port, or °C, RS-232 is available. modes. SoftTemp Data Acquisition Software Time Cons 63% of final temperature. Is defined as the time required to reach reading stops changing, An accurate reading is obtained when the normally 5 to 10 time constants. Application Note — Definitions Note Application Thermistor a change in electrical Is a thermally sensitive resistor which exhibits resistance with a change in its temperature. [email protected]

email -20 to 320°C (whichever is greater) ±2% of reading or ±4°F/2°C 1°F/°C fixed 0.95 Backlit LCD 2000 9V battery 6:1 (at 6 inch distance measure 1 inch target) x 44 x 40 mm (6.7 x 1.7 x 1.6 in) 170 200 g (6.4 oz) 1-508-893-8999 Product IR Thermometer To order call Excellent for verifying temperature in a non-contact manner Use for solvents, hot plates, and animal temperatures without contact Measures to 320°C Large LCD display with backlighting Built-in laser pointer to improve aim switchable °F/°C covers 90% of Fixed emissivity (0.95) surface applications Narrow field of view Audible and visible overrange indicators Automatic data hold Pocket size meter Comes with 9V battery • • • • • • • • • • • • # Order ST1 72-5270 Specifications Range Accuracy Resolution Emissivity Display Power Field of view Dimensions Weight This is a non-contact InfraRed Thermometer with laser pointer It is ideal for measuring surface which measures up to 320°C. temperature of objects which are difficult to reach, unsafe to contact, or you do not wish to disturb. Thermometer InfraRed Non-Contact THERMOMETERS

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EQUIPMENT 82 To order call see page82. These probesareforusewiththePrecisionThermometer, (10 ft)leadterminatingina400Seriesphonejackconnector. to +150°C,exceptwhereotherwiseindicated,andhavea3.1m from 32° to42°C. Theyhaveatemperature range from-40° Interchangeability toleranceis±0.1°Coverthebiologicalrange Thermometer seepage82) withoutlossofaccuracy. interchangably withallThermistorThermometers(Precision All probesinthestandard400Seriescanbeused (J) ST159-9819 AirandGasProbe (I) ST159-9814 SmallSurfaceProbe (H) ST160-2315LargeSurfaceProbe,PTFECoated (H) ST158-9812LargeSurfaceProbe,Vinyl (G) ST160-2317PermanentInstallationTemperatureProbes (F) ST159-9811 GeneralPurposeImmersionProbes,3.2mm (E)  (D)  (C)  (B) ST159-9808* SmallFlexibleVinylRectal/EsophagealProbe (A)ST159-9807* FlexibleVinylRectal/EsophagealProbe ST1 59-9810 GeneralPurposeImmersionProbes,4mm ST1 59-9809 SmallSemi-FlexibleNylonRectal/OralProbe ST1 60-2318SurfaceProbewithStainlessSteelShaft * TipisnowmadeofgreymoldedPVCand isintergraltothecable. 1-508-893-8999 (probes shownarenottoscale) email [email protected] individually. diameter lead.Maximumtemperature100°C.Isolated.Supplied The 3.2mm( The 3.2mm( 7.9 mm( covered toalleviatediscomfort.The4.8mm( nylon tube.Maximumtemperature100°C.Isolated. 2.4 mm(0.09in)diameterby63.5 mm(2.5in)longsemi-flexible Isolated. a 33cm(13in)flexiblevinyltube.Maximumtemperature100°C. readings. Hypo-allergenicmedicalgradeadhesive. skin forgoodthermalconductivity.Minimizesdistortionofprobe For holdingSkinSurfaceTemperatureProbessecurelyagainst Adhesive Patches ST1 59-9807 Order # ST1 59-9809 Order # ST1 59-9808 Order # ST1 60-1908 Order # ST1 59-9815 1/8" D 1/8" D 3/16" MAX 3/16" MAX 5 ⁄ Thermistor Probes continue on the next page. next the on continue Probes Thermistor 16 in)longprobetipismountedona3.6mm(0.14 2-1/2" 13" 1 1 ⁄ ⁄ 8 8 Flexible VinylRectal/EsophagealProbe,pkg.of1(A) Product Small Semi-FlexibleNylonRectal/OralProbe,pkg.of1(C) Product Small FlexibleVinylRectal/EsophagealProbe,pkg.of1(B) Product Adhesive Patches,28.6mm(2 Product Adhesive Patches,38mm(1 in)diameterprobetipismountedontheendofa in)diameterprobetipismountedontheendof 3/32" D 3/32" D web 9/64" D THERMISTOR PROBES www.harvardapparatus.com

Probe (B) Rectal/Esophageal Small Flexible Vinyl This probeisflexibleandvinyl Esophageal Probe (A) Flexible Vinyl Rectal/ Probe (C) Nylon Rectal/Oral Small Semi-Flexible 1 ⁄ 2 • • • in),pkg.of100 1 ⁄ 8 in),pkg.of100 3.2 seconds Time constant 7 seconds Time constant 1.4 seconds Time constant 3 ⁄ 16 in)diameterby

83 SURGICAL EQUIPMENT

in) thick sensor disk in) diameter by 8 8 ⁄ ⁄ 1 in) diameter sensor 3 ( 16

⁄ Time constant 10 second Time constant Time constant 1.1 second Time constant 0.3 second 3 • • • Cable Dimensions, W x Thick in) (I) 2.5 x 0.8 mm (0.1 x 0.03 3.4 x 1.3 mm (0.13 x 0.05 in) (H) in) diameter stainless steel 2 ⁄ (K) Air and Gas Probe This probe is for temperature Small Surface (J) Probe (H,I) Probes Surface Large Ideal for cuvette, water other bath, skin surface and flat surface temperature measurements. The 9.5 mm ( 3.2 mm 1 in). Maximum temperature 8 ⁄ 7 www.harvardapparatus.com h Cable PTFE Coated Vinyl web ST1 59-9814 1/4" D 1/16" D 1-7/8" 10' Product Air and Gas Probe (K) Product Small Surface Probe with Non-Detachable Lead (J) Maximum Temp. 150°C 100°C 12" Flat Lead, Vinyl, 0.13" Widt 0.05" Thick 24" Flat Lead, Teflon, 0.10" Width Flat Lead, Teflon, 0.10" 0.03" Thick 1/8" 1/2" D 1/8" in) thick disk is attached to a 61 cm (24 in) PTFE covered wire. cm (24 in) thick disk is attached to a 61 3/8" D 3/16" D 3/32" D * Tip now made of gray molded PVC and is integral to the cable 32 ⁄ 3/8" D # Order ST1 59-9819 3 # Order ST1 59-9814 # Order ST1 60-2315 ST1 59-9812 cage around the epoxy encapsulated thermistor. Length from the mm (1 tip to the shaft end is 47.6 150°C. Isolated. Supplied individually. measurements in test rooms, incubators, environmental chambers, gas streams, etc. It has a 12.7 mm ( has a stainless steel patient side and epoxy back. Two probes are side and epoxy back. Two probes are has a stainless steel patient covered 3.1 m probe has a flat, vinyl available. The ST1 59-9812 in a 400 series phone jack connector. The (10 ft) lead terminating 305 mm (12 in) PTFE coated lead connected ST1 60-2315 has a flat, covered lead with a 400 series phone jack to a 3.1 m (10 ft) vinyl connector. disk has a stainless steel patient side and epoxy back. The 2.4 mm disk has a stainless steel patient side and epoxy ( Ideal for cuvette, water bath, skin surface and other flat surface Ideal for cuvette, water bath, skin surface and temperature measurements. The 4.8 mm ( isolated, connector is Maximum temperature 150°C. Probe disk is Supplied individually. not isolated. Supplied with detachable lead.

[email protected] email Time constant Time constant 0.6 second Time constant 3.4 second in) (F) in) (E) 8 ⁄ • 1 • 16 ⁄ 3 in), pkg. of 1 (G) Purpose General These heavy duty, immersible (E,F) Immersion Probes with Probe Surface Shaft (D) SS Installation Permanent (G) Probes These probes are for permanent installation in pipes and closed vessels. The probe’s fittings can withstand 500 p.s.i. The 4 mm 2 ⁄ 1 Product 3.2 mm ( 4 mm ( in) handle. Maximum temperature 150°C. in) handle. Maximum 2 ⁄ 1 1-1/2" 7/8" 1/8" N.P.T. 1-3/16" 1-508-893-8999 1-5/16" 1/8" N.P.T. Product Temp. Probe, 11.4 cm (2 Constant Time 2.5 sec Product Steel Shaft (D) Surface Probe with Stainless 3.4 sec 5/32" D in) long stainless steel shaft. Maximum temperature in) long stainless steel shaft. Maximum temperature 2 ⁄ 1 3-5/8" in) National Pipe Thread compression fitting. The shorter To order call 8 4-1/2" 4-1/2" ⁄ 1" ST1 60-2316 1 (

5/64" 5/32" D 13/32" D # Order ST1 60-2317 # Order ST1 59-9811 ST1 60-2318 # Order ST1 59-9810 Isolated. Supplied individually. Ideal for water baths, skin surface, oral and other flat surface Ideal for water baths, Also for some air temperature temperature measurements. sensor disk has a in) diameter mm (0.41 applications. The 10.3 side and epoxy back. The 2 mm (0.08 in) stainless steel patient to a 82 mm (3.2 in) stainless steel shaft which thick disk is attached (1 is attached to 38.1 mm probes are for liquids, gases and semi-solids. Not good for surface probes are for liquids, gases and semi-solids. mounted on the end of temperature measurements. The sensor is a 114 mm (4 150°C. Isolated. Available in two shaft diameters. Supplied 150°C. Isolated. Available in two shaft diameters. individually. (0.16 in) diameter stainless steel shaft is supplied complete with a 3.2 mm shaft probe has a detachable lead. Maximum temperature is 150°C. Not isolated. THERMISTOR PROBES THERMISTOR

SURGICAL

EQUIPMENT 84 Options Components Included Parameters Measured Key Features Tail Temperature Evaluation inRodents InfraRed Thermometer for Cutaneous To order call • • • • • • • • • Calibration Certificateuponrequest 12 monthswarranty Instruction manual Current temperaturevalues(Celsius) Fast reading Highly accurateandrepetitive Easy measurementsevenonmicetails No physicalcontactrequired Allows measurementsonverysmallsurfaces 1-508-893-8999 email [email protected]

to takeareading. like skin,tail,nose,genitalarea.Thesensormusttouchtheanimal variations. It’sthereforeadvisabletomeasureonnakedsurfaces, air caughtinthehair,thuscreatingimportantmeasurement The measurementtakenintheanimalfurmayincludeambient applications aswell. range from25°to40°Candwillprovebeusefulforotherlab The InfraRedthermometerisespeciallyaccurateonatemperature tails–with highaccuracyandrepeatability! This thermometerthusallowseasymeasurements–evenonmice can bethecasewithotherindustrialtypeinfraredthermometers. small surfaceswithoutinfluenceofenvironmenttemperature,which the IR sensor were adjusted in order to allow measurements on very With thisthermometer,theopticaldimensionandpositionof manner. cutaneous temperatureinsmallrodentsaveryfastandaccurate The ST175-0046 InfraRedThermometerwasdesignedtomeasure ST1 76-0120 ST1 75-0046 Order # Emissivity Measurement Size Minimum to Object Minimum Distance Distance Ratio Range Global Measurement 24-40°C Accuracy outside Accuracy Resolution Technical Specs Specifications

- BSBIO152IRB Model

web www.harvardapparatus.com Fixed, undisclosed value Fixed, undisclosedvalue 3 mm From 0mm,sensormusttouchanimal 1:1.5 -20° to+200°C Range 1%±1°C 0.3°C from25°to40°C 0.1°C For aroomtemperatureof15°to25°C Calibration Certificate Upon Request Calibration CertificateUponRequest InfraRed ThermometerforRodents Product THERMOMETER

85 SURGICAL EQUIPMENT

ICU with Flat Cover ICU with Flat www.harvardapparatus.com web Canister-style nebulizer for nebulizing the internal Canister-style nebulizer for nebulizing the 3 µm atmosphere with water particles from 1 to antibiotic 9 cc medication nebulizer for delivering an aerosol mist with particles from 1 to 3 µm Air/oxygen blender oxygen Medium and large dome covers come with flowmeter (flowmeter is an add-on accessory for the small dome cover). Temperature and humidity gauge DISS oxygen hose fitting and elbow hose connectors 2.1 m (7 ft) medical air supply tubing and 30.5 cm long x 2.5 cm OD (12 x 1 in) corrugated hose Water conditioner, filler cap Water level gauge, Spin/Venting handport covers Cage Divider - Canister-style humidifier -  -  -  -  -  -  -  -  -  -  -  Warmer Base Only These Intensive Care Units accommodate animals up to 20 pounds These Intensive Care Units accommodate animals sizes). The optional (small size) or up to 80 pounds (medium/large cover provides perch facilitates treatment for birds. The Domed 360° observation of the animal. Cover with Dome or Flat Units Care Intensive include: unit) (complete For specifications and ordering information, see facing page.

[email protected] email 1-508-893-8999 To order call radiate heat, eliminating the need for pump, fan or motor. radiate heat, eliminating the need for pump, Heavy gauge fire retardant plastic is heated 37°C Therapeutic temperature range of 25° to is by thermostatic resistance control and temperature monitored with direct water contact sensor walls of unit Natural convection currents created in the humidity or nebulization to 20 lbs, Small units can accommodate animals up Medium and Large units can accommodate animals up Medium and Large units can accommodate to 80 lbs carbon Covers include vents to allow warm air and dioxide to escape Complete unit accommodates administration of oxygen, Complete unit accommodates administration • • • • • • ICU with Dome Cover ICU with Dome Temperature Control Temperature The water-jacketed warmer base is made of heavy gauge fire water the of temperature the maintains heater The plastic. retardant accurately through resistance heating controlled thermostatically with a direct water-contact sensor. This creates a natural thermal convection current within the walls of the unit and the heat is radiated to ensure a constant, sustainable temperature within a safe to 100°F wherever the animal lies. This therapeutic range of 75° combination of radiant heat and convection currents preclude the use of a pump, fan, or motor which may spark and ignite with the use of oxygen. Vents on the top of the heated or unheated covered units allow warm air to rise and escape with any carbon dioxide build up. It is the combination of therapeutic heat with respiratory therapy that creates a stand-alone ICU (Intensive Care Unit). For post-operative or hypothermic animals, these Intensive Care Units provide a warm, moist, and/or oxygen-enriched environment. Each complete Intensive Care Unit consists of an electrically heated Warmer Base and a transparent plastic dome or flat cover. Units Care Small Animal Intensive INTENSIVE CARE UNITS CARE INTENSIVE

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EQUIPMENT 86 ST1 60-4885 ST1 60-4884 ST1 60-4880 ST1 60-4881 Accessories Flat CoverdOnly Dome CoversOnly Covers Only 230 VAC,50Hz 115 VAC,60Hz Warmer BaseOnly 230 VAC,50Hz 115 VAC,60Hz Complete ICUwithFlatCover 230 VAC,50Hz 115 VAC,60Hz Complete ICUwithDomeCover Configuration Temperature Range Heater Controls Intensive CareUnitwithFlatCover Intensive CareUnitwithDomeCover Flat CoverOnly Dome CoverOnly Warmer BaseOnly Specifications To order call Large Medium Small Large Interior Medium Interior Small Interior Dimensions (HxWD): Large Medium Small Dimensions (HxWD): Large Medium Small Large Medium Small Large Medium Small Dimensions (HxWD): Interior Exterior Interior Exterior Interior Exterior Interior Exterior Interior Exterior Interior Exterior 1-508-893-8999 H xWD,109.2 106.7 x61 cm(43 x42 x24 in) Large TransportCart forLargeIntensiveCareUnits, Units. HxWD,109.2 x106.761 cm(43 x42 x24 in) Medium TransportCartforIntensive Care Oxygen FlowmeterforSmallIntensive CareUnits Metal CageCoverforSmallWarmerBase ST1 60-4882 ST1 60-4877 ST1 52-4843 ST1 52-4835 ST1 75-0131 ST1 75-0130 ST1 52-4785 ST1 52-4777 Small 25° to37°C (75° to100°F) 120 W&210Heaters2Thermostats 2 +100WHeaters&Thermostats 90 WHeater&1Thermostat 31.1 x63.5 x101 cm(12.25x2539.75 in) 31.1 x63.5 x78.7 cm)(12.25x2531in) 16.5 x39.4 x56.5cm(6.515.522.25in) 61 x63.5 x101 cm(24 x2539.75 in) 67.3 x75.6 x107.6 cm(26.5 x29.75 x42.38 in) 61 x63.5 x78.7 cm(24 x2531in) 67.3 x75.6 x84.8cm(26.5 x29.75 x33.375 in) 37.5 x39.4 x56.5cm(14.75 x15.522.25in) 43.18 x47 x67 cm(17x18.526.375 in) 31.1 x63.5 x101 cm(12.25x2539.75 in) 31.1 x63.5 x78.7 cm(12.25 x2531in) 16.5 x39.4 x56.5cm(6.515.522.25in) 31.1 x63.5 x101 cm(12.25x2539.75 in) 31.1 x63.5 x78.7 cm(12.25 x2531in) 16.5 x39.4 x56.5cm(6.515.522.25in) 31.1 x63.5 x101 cm(12.25x2539.75 in) 33 x75.6 x107.6 cm(13x29.75 x42.375 in) 31.1 x63.5 x78.7 cm(12.25 x2531in) 33 x75.6 x84.5cm(1329.75 x33.25in) 16.5 x39.4 x56.5cm(6.515.522.25in) 19.7 x45.1 x67 cm(7.75 x17.75 x26.375 in) email ST1 75-0136 ST1 60-4878 ST1 60-4876 ST1 60-4875 ST1 75-0133 ST1 75-0132 ST1 52-4801 ST1 52-4793 Medium [email protected] ST1 75-0137 ST1 60-4879 ST1 52-4868 ST1 524850 ST1 75-0135 ST1 75-0134 ST1 52-4827 ST1 52-4819 Large

Warm AirChamber heating characteristicsoftheunittominimizeovershoot. being heated.AvariableHysteresisloopallowstheusertotailor LED display.Thedisplayalsoindicateswhenthechambersare controller. Thesetandactualtemperaturescanbeviewedonthe temperature canbeseteasilyonthefrontpanelofheater indicated onalargeeasytoviewredLEDdisplay.Thedesired mounted insidetheunitmonitorsairtemperature,whichis with electronicallycontrolledheaters.Atemperaturesensor The WarmAirChamberismadeofatransparentplasticcabinet facilities. addition toallsmallanimalresearchand/orveterinarycarecore and cannulationforbothratsmice.Thisproductisaperfect operative warmingforsuchapplicationsastailveinbleeding containment box.Itisidealforpostoperativerecoveryandpre- This chamberisadigitallycontrolled,fanassistedheaterand containing fourindividualanimalcontainmentchambers. Introducing thenewHarvardApparatusWarmAirChamber, ST1 34-1066 ST1 34-1447 Order # Dimensions, HxWD: Specifications • • • • Front Individual Enclosure, Rear Individual Enclosure, Overall, Front Overall, Rear pre-operative warming Ideal forpostoperativerecoveryand Hysteresis sonotemperatureovershoot Suitable forbothratsandmice Digital fanassistedanimalwarming Warm AirChamber,4Divisions,230 VAC, 50Hz Warm AirChamber,4Divisions,115VAC, 60Hz Product web INTENSIVE CAREUNITS www.harvardapparatus.com 100 x150300mm(3.945.9111.81in) 250 x150300mm(9.845.9111.81in) 100 x600300mm(3.9423.62 x11.81 in) 250 x600300mm(9.8423.62 x11.81in)

87 SURGICAL EQUIPMENT

Chamber Recovery Unit www.harvardapparatus.com web 160 x 305 x 425 mm (6.3 x 12 x 16.7 in) 160 x 305 x 425 mm (12 x 12 x 16.7 in) 305 x 305 x 425 mm (21.3 x 81.3 in) 540 x 320

Product Small Thermal Barrier, 115 VAC, 60 Hz Small Thermal Barrier, 230 VAC, 50 Hz Large Thermal Barrier, 115 VAC, 60 Hz Large Thermal Barrier, 230 VAC, 50 Hz Product 60 Hz Control Unit for Heated Chamber System, 115 VAC, 50 Hz Control Unit for Heated Chamber System, 230 VAC, Vetcare Heated Pad Chamber Pads reach approximately 36°C when placed on a steel table in room with an average temperature of 21°C For use with Large Animal Operating Tables, see pages 68-69. Waterproof Uniform heat is supplied by 5 cm (2 in) wide low voltage stainless steel heater bands that deliver 10 watts per square foot • • • • # Order ST1 72-0492 ST1 72-0493 ST1 72-0494 ST1 72-0495 Dimensions Chamber Base Overall Heated Pad # Order ST1 34-1242 ST1 34-1240 ST1 34-1241 ST1 34-0508 Two sizes are available. The small size measures 33 x 58.5 cm cm (13 x 40 in). Each (13 x 23 in). The large size measures 33 x 102 barrier is supplied with its own low voltage transformer with a 2 m (6 ft) grounded power cable and a 2 m (6 ft) lead to the pad. Barrier Thermal Control Unit Control thermostat for The temperature can be adjusted via an electronic includes control unit, low, medium and high. A complete system must be purchased heated pad and chamber. All components separately.

[email protected] email Vetcare Heated Pad Vetcare Heated 1-508-893-8999 To order call Control Unit Thermal Barrier Vetcare Heated Pad Heated Vetcare surface is clear anodized The lightweight, heated Vetcare Heat Pad is detachable from the aluminum, bonded to ABS housing. The pad The sensor for the control box to assist with storage and cleaning. the pad can be thermostat is located on the element and therefore completely covered without overheating. Chamber Recovery Unit Chamber Recovery place the animals andThe chamber has an acrylic base in which to and has a ventilation discbedding as required. The top is clear acrylic pad and control unit. to control the environment. Must also purchase (Recovery Unit and Operating Pad) The Vetcare unit has been (Recovery Unit and Operating Pad) The Vetcare to animals whenever developed to provide supplementary heat It can also be required such as during recovery from anesthesia. separately. used as an incubator. All components are purchased Chamber System Heated “Vetcare” The RECOVERY CHAMBER & THERMAL BARRIER THERMAL & CHAMBER RECOVERY

SURGICAL

EQUIPMENT 88 bedding andwaterbottleforusageoveralongerperiod. directly insideorasmalltypecagecanbeplacedwith The unitisusedinahorizontalposition.Animalscanbeplaced Small AnimalRecovery panel toobservetheanimals. Temperature isindicatedonadigitaldisplay.Thereclearvertical 16° to45°C. Theunitcanbeboostedwithfanassistanceifrequired. The operatingtemperatureofthesensorisadjustablefromapprox. create twocompartments. door manufacturedfromPerspex.Optionaldividerscanbeaddedto for fluidwarmingcabinet.ThecasingisABSplasticandhasaclear small animals.Thisunitcanalsobeadaptedforbirdsandaswell Designed specificallyasapost-operativerecoverychamberfor Warming Cabinet Small AnimalRecovery Chamber/ To order call for UsewithBirds Oriented Vertically ST1 34-0932 CareFRESH® AbsorbentSheets 1-508-893-8999

email CareFRESH isaregistered trademarkofInternationalAbsorbants, Inc. [email protected]

a plasticbag. Maximum fluidcapacityis8liters(infusionbags). veterinary practicesthiscabinetisidealforbusysurgeries. be usedforwarmingfluidsandinfusionbags.Inbothmedical “overheat” safetydeviceandfaulttestcircuitbuiltin.Theunitcan This unitismanufacturedtoEN601-1 1988.Thecabinethasan Fluid Warming Cabinet required. or humiditysupplycanbefedthroughtheventholesindoorif door willsupportafoodholderand/orperchifrequired.Oxygen operating functionsforbirdsassmallanimals.Theclearpanel This isthesameunitorientedinaverticalposition.Ithas Small Avian Recovery/Hospitalization Cabinet from 6.4mm( An individualsheetmeasures40.6x50.8cm(1620in).Select various spillsandanimalaccidents. super absorbentcellulosefiber,theyarealsoidealforcleaning up They canalsobeusedtoprotectexaminationtables.Madefrom a animal cages,theyhelpmakeexcrementcleanupfastandeasy. help preventbodyheatlossaftersurgery.Whenusedundersmall These disposablesheetsareidealfornumerousapplications.They CareFRESH ST1 34-0934 ST1 34-0516 ST1 34-0932 Order # ST1 63-0202 Dimensions, HxWD: Specifications ST1 63-0201 Order # ST1 34-0517 ST1 34-0933 Order # • • • Internal Overall External Overall accidental spills recovery, protectingexamtables,andforcleanupof Ideal forpostsurgery,maintainingbodyheatduring Inexpensive Super absorbent Divider (Creates2CompartmentswithinWarmingChamber) 230 VAC,50Hz Small AnimalRecoveryChamber/WarmingCabinet, 115 VAC,60Hz Small AnimalRecoveryChamber/WarmingCabinet, Product CareFRESH® AbsorbentSheets,3.2mm ( 100 sheets CareFRESH® AbsorbentSheets,6.4mm ( Product Fluid WarmingCabinet,230VAC,50Hz Fluid WarmingCabinet,115VAC,60Hz Product 200 sheets 1 ⁄ 4 ® in)or3.2mm( AbsorbentSheets web www.harvardapparatus.com 38 x27 x21cm(1510.68.3in) 49 x3327 cm(19.3x1310.6in) RECOVERY CHAMBER 1

⁄ 8 in)thickness.Theyaresuppliedin

1 1 ⁄ ⁄ 8 4 in) thick, in)thick, in) thick, in)thick,

89 SURGICAL EQUIPMENT 50 cm (20 in) ST1 72-6833 ST1 72-6834 ST1 72-6835 ST1 72-6836 ST1 72-6837 ST1 72-6839 FrameST1 72-6839 with ST1 72-6816 Loupe ST1 72-6828 ST1 72-6829 ST1 72-6830 ST1 72-6831 ST1 72-6832 46 cm (18 in) www.harvardapparatus.com ST1 72-6816 ST1 72-6817 ST1 72-6818 ST1 72-6819 ST1 72-6820 42 cm (16 in) web ST1 72-6818 ST1 72-6811 ST1 72-6812 ST1 72-6813 ST1 72-6814 ST1 72-6815 Distance Working 34 cm (13 in) Product mm (5.3 in) Black, Frame Temple, 135 mm (5.3 in) Blue, Frame Temple, 135 Black, Frame Temple, 150 mm (5.9 in) Blue, Frame Temple, 150 mm (5.9 in) ST1 72-6829 SuperVu SL 2.5x SuperVu SL 3.0x SuperVu XL 3.5x SuperVu XL 4.5x SuperVu XL 5.5x Loupes Magnification Surgical SuperVu Magnification Loupes Surgical SuperVu Magnification for Sport Frames # Order ST1 72-6838 ST1 72-6839 ST1 72-6840 ST1 72-6841 The prismatic quality of these lenses guarantees a crisp, true The prismatic quality of these lenses guarantees This system offers edge image, even at the highest magnification. that is ideal for surgical to edge clarity and precise color rendition with an anti- applications. These precision lenses are treated The compact design reflective coating to produce a superior image. and comfort. These and reduced weight provide optical stability g (2.0 oz). lenses weigh only 57 flip lever to easily Both systems are supplied with an autoclavable cloth and move the lenses from your line of sight, a cleaning and sports frames or storage case. SuperVu magnification loupes headbands must be purchased separately. surgery in a Choose a 34 cm working distance for performing cm surgery in a 42 seated position and a working distance of standing position. SuperVu XL (continued) XL (continued) SuperVu Note: Must purchase sports frames or headbands separately- not included with loupes. [email protected] email 1-508-893-8999 To order call Ideal for small animal surgery distances Choice of 5 magnifications and 4 working Offers a clear true image Superior optical quality eliminates eyestrain your Individual inter-pupillary adjustment ensures loupes are tailored to fit to your eyes • • • • • ST1 72-6838 Frame with ST1 72-6814 Loupe MAGNIFIERS The SuperVu XL System a prismatic system that has a total of five advanced for magnification higher deliver to prism roof a and lenses surgical procedures. This system delivers 3.5x, 4.5x, and 5.5x magnification. SuperVu XL SuperVu The SuperVu SL System is a Galilean optical system encased in a The SuperVu SL System is a Galilean optical of a double objective metal alloy shell. The SuperVu SL is comprised and high power negative lens delivering 2.5x and 3.0x magnification and provides the widest field of view and excellent working depth. The benefit of this system is ease of use. Movement while maintaining focal clarity is made possible due to a superior depth of field. The ultra-lightweight aluminium bar and individual interpupillary adjustment provides stability for the mounted loupes and optimal focal alignment, eliminating headache and eyestrain. High quality light-weight glass and ultra-light aluminium are combined to guarantee supreme optical clarity and optimal comfort. These lenses weigh only 40 g (1.4 oz) giving you optimal comfort. Multi-coated optics cut down on reflection and deliver superb color rendition. SuperVu SL SuperVu The SuperVu System is a superb optical quality magnification The SuperVu System is a superb optical quality pupil alignment. system with laser designed optics and precise quality lightweight These lenses are constructed of the highest metal alloy shell to optical glass and feature an ultra-lightweight offer clarity, comfort, and fit. Loupes Magnification Surgical SuperVu

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EQUIPMENT 90 purchased separately andareinterchangeable. magnifier issupplied withasinglelens.Otherlenses maybe The foreheadrestisdiscontinuous toallowaircirculation.Each fitting theshieldcanbenotched intodifferentheightadjustments. and canbeconvenientlypushed upwhennotneeded.Forindividual The shieldiscloseonallsidesto protecttheeyesfromstraylight well asforthosewhoarenot. eye spatialdepthsight.Itissuitableforpeoplewearingglasses as purposes. Thismagnifierhasabinocularlenswhichfacilitatestwo- up inmagnifiedformbutbothhandsmustremainfreeforwork These headbandmagnifiersareidealwhendetailsmustbepicked and foamliningforgreatercomforteaseoffitting. snap intohighgradeplastichousing.Headbandhasadjustablestrap charging tray. Includes LED,(2)lithiumbatteries,universalpowersupplyand see facingpage. Sport Frame.Loupeandframemustbeorderedseparately, XL MagnificationSystemsandcanbemounteddirectlyona The K-LEDisdesignedtobeusedwiththeSuperVuSLor a convenientstoragecontainerforyourloupes. unit thatcanholdandchargebothpackssimultaneously,aswell complete withtwobatterypacksandauniversalpoweredcharging battery packgiving4hoursofcontinuoususe.Thesystemcomes mounted coaxiallyontheloupebarandispoweredbyalithium long lastingwhitelightpatchofupto18,000lux.The3WL.E.D.is The K-LEDIlluminationSystemheadlightproducesahomogenous, K-LED Illumination System ST1 72-6842 Order # To order call • • • Comfortable andeasytowear Provides 4hoursofcontinuoususe Ultra-bright clip-onlight 1-508-893-8999 K-LED IlluminationSystem Product needed. Interchangeablelenses so itcanberaisedorloweredas ratcheted hingeonlenscover This HeadbandMagnifierhasa Headband Magnifier email • [email protected] Superior opticalquality Leather Padded Headband interchanged betweenusers,makingthistrulyuniversal. can beflippedupwhennotrequired.Theheadbandeasily The viewingangleisfullyadjustableandthemagnificationloupes that addscomfortandflexibilitytoyourMagnificationSystem. Magnification Loupes.Itfeatureshorizontalandverticaladjustment This LeatherPaddedHeadbandisforusewiththeSuperVu Shipping Weight ST1 72-5101 ST1 72-5100 ST1 72-5099 ST1 72-5098 ST1 72-5097 ST1 72-5096 ST1 72-5095 ST1 72-5094 Order # Shipping Dimensions,HxWD: Magnification Lens Specifications ST1 72-6822 ST1 72-6821 Order # • • • • Replacement Lens Magnifier Replacement Lens Magnifier Comfortable Adjustable viewingangle Horizontal andverticaladjustment Use withtheSuperVuMagnificationLoupes Replacement Lens, 3.0x,160mm(6.3in)workingdistance Replacement Lens, 2.5x,180mm(7.1in)workingdistance Replacement Lens, 2.0x,250mm(9.8in)workingdistance Replacement Lens,1.7x,400mm(15.8 in)workingdistance Headband Magnifier,3.0x,160mm(6.3 in)workingdistance Headband Magnifier,2.5x,180mm(7.1 in)workingdistance Headband Magnifier,2.0x,250mm(9.8 in)workingdistance Headband Magnifier,1.7x,400mm(15.8 in)workingdistance Product Replacement LeatherPadsforHeadband Leather PaddedHeadband Product web www.harvardapparatus.com 0.07 kg(0.15lb) 0.4 kg(0.85lb) 15.2 x10.2cm(64in) 25.4 x20.315.2cm(1086in) working distance gradual forvaryingdemandsandallowsmaximum 1.7x, 2.0x,2.5xor3.0x,magnificationsupplyis coating, lenssectionsareinterchangeable Aspheric PXM-Lightweightlenswithsurface MAGNIFIERS

91 SURGICAL EQUIPMENT

www.harvardapparatus.com web Comes complete with lightweight lens, 140 x 100 mm with duplex coating diopters 2x/2.6 7 Watts, 220 V energy-saving PL lamp Gooseneck, flexible arm Sturdy, round table base 68.6 x 38.1 x 30.5 cm (27 x 15 x 12 in) 68.6 x 38.1 x 30.5 cm (27 17.8 x 12.7 x 12.7 cm (7 x 5 x 5 in) 25.4 x 20.3 x 15.2 cm (10 x 8 x 6 in) 15.2 x 10.2 x 10.2 cm (6 x 4 x 4 in) 4.2 kg (9.2 lb) 0.3 kg (0.7 lb) 0.8 kg (1.7 lb) 0.1 kg (0.2 lb) 75 x 100 mm, 2.8x/7 diopters x 100 mm, 2.8x/7 75 Super-Lite, 110 VAC, 60 Hz Super-Lite, 220 VAC, 50 Hz Repl. Bulb for Super-Lite Product Gooseneck Stand Magnifier Additional Lens, Aspeheric PXM Lightweight Lens, Superior optical quality Magnifier Additional Lens Light Source Replacement Light Magnifier Additional Lens Light Source Replacement Light • Specifications Lens Magnifications Illumination Arm Base Shipping Dimensions, H x W x D Shipping Weight ST1 72-5106 ST1 72-5107 ST1 72-5108 # Order ST1 72-5104 ST1 72-5105 Base Magnifier with Desktop Gooseneck Stand to be free. They are Designed for vision tasks that require hands animal surgery or suitable for detailed procedures such as small small components. industrial tasks such as examining or assembling lens as standard. diopter This magnifier is supplied with a 2x/3.2 diopters 2.8x/7 A second lens is available separately that provides purchase the Super-Lite magnifications. If illumination is required, lens and provides 7 lightsource. It easily clips on the side of the watts of light.

[email protected] email swiveling range of magnifier head: horizontal vertical and radial ±90° ±450°, mm, For tabletop thickness from 18-74 cable length 3 meters in) cm (12 x 12 x 52 30.5 x 30.5 x 132.1 25.4 x 15.2 x 10.2 cm (10 x 6 x 4 in) x 30.5 x 20.3 cm (14 x 12 x 8 in) 35.7 4.8 kg (10.6 lb) lb) 0.2 kg (0.45 lb) 6.7 kg (14.75 Aspheric PXM-Lightweight lens with cera-tec hard mm coating, ø 132 diopters usable with spectacles 2.8x/7.1 1.9x/3.55pr for near and distance 9 Watt PL-Lamp Robust articulated support with integrated cable routing, maximum operating radius 900 mm, 1-508-893-8999 Product Vario Stand Magnifier with 2 Lenses, 110 VAC, 60 Hz Vario Stand Magnifier with 2 Lenses, 220 VAC, 50 Hz Replacement Lens Protectors, pkg. of 3 Table Stand To order call Superior optical quality Magnifier Lens Protectors Table Stand Magnifier Lens Protectors Table Stand • # Order ST1 72-5073 ST1 72-5074 ST1 72-5076 ST1 72-5075 Table Clamp Shipping Dimensions, H x W x D Shipping Weight Specifications Lens Magnification/Optic Illumination Support This stand magnifier offers the user a high degree of flexibility when This stand magnifier offers the user a high calculated to infinity. selecting working distance through its optics against dust. The lens has an integrated cover to protect rotatable lens, This magnifier is supplied complete with additional iron stand weighing table clamp and lens protector. A heavy cast a solid base on 6 kg (13.2 lbs) available as an accessory provides protects the which to mount the magnifier. The lens protector procedures such as bottom of the lens when working with rough bone drilling. Magnifier Stand Vario STAND MAGNIFIERS STAND

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EQUIPMENT 92 (48 in These magnifiersarestand-mountedandprovideupto310cm Stand-Mounted Magnifiers magnifier lightsoldseparately. metal base,polishedsteelhorizontalandverticalrods,aclamp. all focalpointdepthsanddistances.Suppliedwithaheavyduty needs nofocusingandmaintainscompletedepthoffieldthrough To order call ST1 52-5484 ST1 52-5494 ST1 52-5493 ST1 52-5486 ST1 52-5485 Order # • • • • 2 Light soldseparately vertical rodsandclamp Supplied withheavydutymetalbase, No focusingneeded Provide upto310cm ) ofviewingarea.Thespecialprecisiongrounddiopterlens 1-508-893-8999 On/Off switch;9inchgroundcord Light forMagnifier,20watt;115V,60Hz;16inchgooseneck; 15 x20cm(68in) 15 x20cm(68in) 15 xcm(66in) 15 xcm(66in) Lens Dimensions 2 (48 in email 2 ) ofviewingarea [email protected] 5X (doublelens) 2.5X (singlelens) 6X (doublelens) 3X (singlelens) Magnification 2

be usedwithspectaclesfornearanddistance. lamp, whichisattachedtilteddownwards.Thestandmagnifiercan Optimum illuminationoftheviewingareaismadepossibleby of thesupportandmagnifierheadallowforvariablepositioning. stable jointedsupportwithintegratedcable.Theadjustablequality The readingglassheadisattachedtothetabletopbymeansofa laboratory useitisidealforviewinganentiremouse. printed pageforthefirsttimeusingthisworldwideinnovation.For a largerworkingarea.Itispossibletoviewthedetailofanentire The Vario-MaxiStandMagnifierwasdevelopedtoeasilymagnify Vario-Maxi Stand Magnifier ST1 72-5072 ST1 72-5071 Order # Shipping Weight H xWD Shipping Dimensions, Table Clamp Support Illumination Magnification/Optic Lens Specifications • Superior opticalquality Vario-Maxi StandMagnifier,220VAC, 50Hz Vario-Maxi StandMagnifier,110VAC,60Hz Product web www.harvardapparatus.com 6.1 kg(13.4lb) 30.5 x132.1 cm(12x1252 in) 3 meters For tabletopthicknessfrom18-74 mm,cablelength the magnifierhead:vertical±90°,radial±90° Maximum loaddistance900mm,turningrangeof 11 WattPL-Lamp and distance 1.75 x/3.0 dioptersusablewithspectaclesfornear coating, ø220mm Aspheric PXM-Lightweightlenswithcera-techard STAND MAGNIFIERS

93 SURGICAL EQUIPMENT

www.harvardapparatus.com web Product Gleamer® with Floor Stand, 115 VAC, 60 Hz VAC, 50 Hz Gleamer® with Floor Stand, 230/240 Gleamer® with Extension Arm and Universal Wall Mount, 115 VAC, 60 Hz Gleamer® with Extension Arm and Universal Wall Mount, Hz VAC, 50 230/240 Watt, pkg. of 4 Replacement Bulb for Gleamer®, 35 # Order ST1 72-3839 ST1 72-3840 ST1 72-3843 ST1 72-3844 ST1 72-3851 The patent pending Gleamer® is designed to the most demanding The patent pending Gleamer® is designed to compact design, specifications: high intensity, cool operation, color 3,700°K and value. With 4,166 footcandles of intensity, gooseneck temperature, and a (combination) 16 inch sturdy offers extensive and optional 15 inch extension arm, Gleamer® flexibility where top reach, maximum convenience, and superior performance, reliability, and low cost are required. regulatory requirement For rugged construction, the most stringent light of choice. Even and cool operation, the Gleamer® is the task illumination bulb with the Gleamer’s compact design and high heat source, its unique venting system and energy-absorbing exchanger assures both a cool beam and housing. and superb quality The Gleamer’s advanced styling, high intensity, is unmatched by any other light in its category. Put a Gleam in your listing… you’ll 2601 35 watt task light with UL eye and see the first select the Gleamer® for your all-purpose light. Gleamer is a registered trademark of Burton Medical. [email protected] email 1-508-893-8999 Lights Exam ® To order call 4,166 footcandles (45,000 lux) – Nearly 35% brighter! lux) – Nearly 35% 4,166 footcandles (45,000 color temperature (natural coloring) 3,700°K W halogen bulb; 4,000 hr life 35 Easy bulb replacement without tools beam; light can Cool housing temperature and cool light discomfort be in continuous use for hours without causing to physician or patient positioning ridges Convenient positioning with ergonomic base Floorstand includes unique space-saving (casters included) High-quality, space-saving 4-caster base – safe and flexible portable movement with locking feature in 2 of 4 casters Certified UL 60601-1/60601-2-41 Made in the USA • • • • • • • • • • Gleamer SURGICAL LIGHTS SURGICAL

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EQUIPMENT 94 Super Exam50 isaregisteredtrademark ofBurtonMedical. To order call 1-508-893-8999 email [email protected] light issuitableinceiling,wall,floor,railandtablemounting. system collectsandconcentratesthelightinaprecisebeam.This maximum lightoutputandcolorrendering.Aduallensoptical class. TheSuperExam50®usesthelatesthalogentechnologyfor system. Thehorizontalandverticalmovementisthebestinits The SuperExam50®hasahighlyflexible,self-balancingarm Super Exam 50 as longconventionaltask&examination products. at 40,000hoursoflife,theSuperExam50®LEDlasts10to20times light outputequivalentto50wattsofconventionallighting.Rated Uses only15wattsofpower,theSuperExam50®LEDproduces the accurate examination. precisely controllednaturalwhitelightthatissoimportantforan technology inthishighlyengineeredopticalsystemdeliversthe versatility iswheretheSuperExam50®LEDreallyshines.The Delivering valuethroughlongerlife,lowerenergyconsumption and system. The horizontal and vertical movement is the best in its class. The SuperExam50®LEDhasahighlyflexible,self-balancingarm Super Exam 50 ST1 72-9574 ST1 75-0152 ST1 72-9573 ST1 75-0151 ST1 75-0150 Order # ST1 75-9941 ST1 72-9940 ST1 75-0154 ST1 75-0153 Order # • • • • • • • • • • • • • • • • 3800 High intensityof45,750 luxat 61 cm(24 in) 4000 High-intensity of39,000 luxat61 cm (24 in) IEC 60601-1/ 60601-2-41, CEmarked or wallrail Rail mountbracketthatcanbeattachedtoabedrail Drift-free K-armwith107 cm(42 in)armrange Universal inputvoltage LED lightmodulewith40,000hourlife Natural whitelight CRI (ColorRenderingIndex)of92 IEC 60601-1/ 60601-2-41/CE marked configurations Floorstand, wall,rail,ceilingandtablemount 50W MR-16bulbwith4,000hourlife Drift-free K-armwith107 cm(42 in)armrange CRI (ColorRenderingIndex)of99 ° ° K colortemperature K colortemperature Replacement BulbsforSuperExam50®Lights,pkg.of3 Super Exam50®TableMount,230/240 VAC,50Hz Super Exam50®TableMount,120VAC,60Hz Super Exam50®FloorStand,230/240 VAC,50Hz Super Exam50®FloorStand,120VAC,60Hz Product Super Exam50®LED TableMount,230/240 VAC,50Hz Super Exam50®LED TableMount,120VAC,60Hz Super Exam50®LEDFloorStand,230/240 VAC,50Hz Super Exam50®LEDFloorStand,120 VAC,60Hz Product web ® ® www.harvardapparatus.com LED SURGICAL LIGHTS

95 SURGICAL EQUIPMENT VAC, 230/240 50 Hz ST1 72-3781 ST1 72-3785 ST1 72-3789 ST1 72-3793 ST1 72-3797 ST1 72-3801 Power 115 VAC, 60 Hz ST1 72-3780 ST1 72-3784 ST1 72-3788 ST1 72-3792 ST1 72-3796 ST1 72-3800 www.harvardapparatus.com web Product Replacement Bulbs, set of 3 Outpatient® II SteriHandle Wall Dimmer Switch Sterile Disposable Light Covers, set of 25 Extension Tube for Drop Ceiling Mount Parts and Replacement Accessories # Order ST1 72-3808 ST1 72-3809 ST1 72-3810 ST1 72-3811 ST1 72-3838 Product Outpatient® II Floorstand Outpatient® II Single Ceiling Outpatient® II Double Ceiling Outpatient® II Wall Mount Single Outpatient® II on Fastrac™ Double Outpatient® II on Fastrac™ * Note: A 76 cm drop tube will be shipped which is suitable for most 2.44 * Note: A 76 by the installer to m (8 to 9 ft.) ceilings. The length can be adapted to 2.74 should be ST1 72-3838 a shorter length. If a longer tube is required, then ordered. Why is the Outpatient® II judged to be the “unanimous light of to be the “unanimous Outpatient® II judged Why is the every centers, and nearly surgical suites, research choice” for required? value pricing are where optimal light and application most wanted, including II offers the features The Outpatient® pattern light in a flood-type pure white, intense focusability, 3,300° K color temperature no-drift arm. With and guaranteed, wired in parallel to assure continuous and three halogen bulbs II is the one light all researchers, light output, the Outpatient® can use for minor surgeries, veterinarians, and physicians The Outpatient® II’s SteriHandle™ is procedures and exams. Disposable Light Covers. autoclavable and accepts double ceiling and combo models are Outpatient® II single ceiling, in) drop tubes. The Outpatient® II is available (30 standard with 0.76 due to its unique design. in complete models only Outpatient is a registered trademark of Burton Medical. SteriHandle is a trademark of Burton Medical. [email protected] email 1-508-893-8999

II ® To order call 8,000 footcandles (86,000 lux) at 61 cm (24 in) cm (24 8,000 footcandles (86,000 lux) at 61 3,300°K color temperature Focuses with central removable, autoclavable SteriHandle™ arm Friction knob allows user to position self-balancing without a tool for drift-free positioning and Cool operation assured with heat filters dichroic coatings “optically Shadow-free operation provided by three improved” 50 W halogen bulbs, each with 2,000 hours average bulb life Bulbs are wired in parallel to assure continuous operation Design allows removal or replacement of SteriHandle™ with one hand (for assuring sterile procedures) Floorstand units include footswitch, locking casters and cord wrap Mounting systems meet California Seismic Codes certified 60601-2-41 UL 60601-1/IEC Made in the USA • • • • • • • • • • • • Outpatient® II Single Ceiling Mount Single Ceiling Outpatient SURGICAL LIGHTS SURGICAL

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EQUIPMENT 96 CoolSpot™ II To order call CoolSpot™ IISingleCeilingMount • • • • • • • • • • • • Made intheUSA UL 60601-1/IEC 60601-2-41 certified Mounting systemsmeetCaliforniaSeismicCodes casters andcordwrap Floorstand unitsincludefootswitch,locking without atoolfordrift-freepositioning Friction knoballowsusertopositionself-balancingarm life onstandardsetting 150 Whalogenbulbprovides600hoursaverage procedures) SteriHandle™ withonehand(forassuringsterile design allowsremovalorreplacementof Removable, autoclavablecenterSteriHandle™ SteriHandle™ forpositioning Easy tocleanhousingdesignwithconvenient Variable spotsizeof5to25cm(210in) Variable intensitysettingsandhighswitch Up to4300°K colortemperature 24 in(61 cm)and5000footcandles(54,000lux)at1m Up to13,000footcandles(140,000lux)at 1-508-893-8999 email [email protected] and OutpatientIIlight.Seebelow. combination unitsareisalsoavailablethatincludesaCoolSpot™II mount model,orasingledoubleFastrac™model.Aunique floorstand model,asingleordoubleceilingmount,wall This lightisofferedinavarietyofmodels.Selectfromsingle cord wrap. The floorstandmodelincludesfootswitch,lockingcastersand tube isrequired,thenordercatalognumberST172-3838. be adaptedbytheinstallertoashorterlengthifdesired.Iflonger is suitableformost2.44to2.74 m(8to9ft)ceilings.Thetubecan The droptubeceilingmounthasa0.76 m(30in)droptubewhich wall mount,orfloorstand. mounting options:ceilingmountdroptube,Fastrac™, and disposablelightcoversample.Itisofferedwithachoiceof This lightissuppliedwitharemovable,autoclavableSteriHandle™ laboratory orexamroomrequiringintensebrightlight. compact headandextremelybrightoutput.Itisperfectforany temperature ofupto4,300°K.It’sasleekupgradethatoffersvery II’s rangeof13,000footcandlesat61 cm(24 in)andcolor CoolSpot™ II.Nolightinitspricecategorycanmatchthe have limitedspaceand/orabudget?Ifso,considerthe Do youneedtheintensityspecificationsofasurgerylightbut CoolSpot, SteriHandle andFastracaretrademarksofBurton Medical. ST1 72-3838 ST1 72-3811 ST1 72-3837 ST1 72-3836 Order # Accessories andReplacement Parts Double CoolSpot™IIonFastrac™ Single CoolSpot™IIonFastrac™ CoolSpot™ IIWallMount CoolSpot™ IIDoubleCeiling CoolSpot™ IISingleCeiling CoolSpot™ IIFloorstand Product Extension TubeforDropCeilingMount Sterile DisposableLightCovers,pkg.of25 Universal SteriHandleReplacement Replacement BulbsforCoolSpot™II,pkg.of3 Product web www.harvardapparatus.com SURGICAL LIGHTS ST1 72-3832 ST1 72-3828 ST1 72-3824 ST1 72-3820 ST1 72-3816 ST1 72-3812 60 Hz 115 VAC, Power ST1 72-3833 ST1 72-3829 ST1 72-3825 ST1 72-3821 ST1 72-3817 ST1 72-3813 50 Hz 230/240 VAC,

97 SURGICAL EQUIPMENT www.harvardapparatus.com web Description Single Ceiling Mount for 8' ceiling Double Ceiling Mount for 8' ceiling Single Ceiling Mount for 10' ceilng Double Ceiling Mount for 10' ceilng Product Outpatient® II/CoolSpot™ II Combo with Fleximount Double Ceiling Mount, 115 VAC, 60 Hz Outpatient® II/CoolSpot™ II Combo with Fleximount Double Ceiling Mount, 220 VAC, 50 Hz Outpatient® II/CoolSpot™ II Combo with Fleximount Double Ceiling Mount, 230 VAC, 50 Hz Outpatient® II/CoolSpot™ II Combo with Fleximount Double VAC, 50 Hz Ceiling Mount, 240 Outpatient® II/CoolSpot™ II Combo with Fastracand Double Trolley, 115 VAC, 60 Hz Outpatient® II/CoolSpot™ II Combo with Fastracand Double Trolley, 220 VAC, 50 Hz Outpatient® II/CoolSpot™ II Combo with Fastrac and Double Trolley, 230 VAC, 50 Hz Outpatient® II/CoolSpot™ II Combo with Fastracand Double VAC, 50 Hz Trolley, 240 230 VAC, 50 Hz ST1 72-3978 ST1 72-3979 ST1 72-3980 ST1 72-3981 # Order ST1 72-3804 ST1 72-3805 ST1 72-3806 ST1 72-3807 ST1 72-3870 ST1 72-3871 ST1 72-3872 ST1 72-3873 120 VAC, 60 Hz ST1 72-3974 ST1 72-3975 ST1 72-3976 ST1 72-3977 APEX Major Surgical Light offers optimum illumination APEX Major Surgical Light quality, no-drift, (120,000 lux / 11,148 fc at 1 meter), the highest arm system with reliability and true color rendering. Outpatient is a registered trademark of Burton Medical. CoolSpot is a trademark of Burton Medical.

[email protected] email 1-508-893-8999 Lights II Combination II/CoolSpot™ ® To order call High-intensity of 120,000 lux (11,148 fc) at 1 meter High-intensity of 120,000 lux (11,148 fc) at color temperature offers pure white illumination 4200°K High CRI (Color Rendering Index) of 95 in) diameter lighthead cm (24 61 Unlimited arm rotation for exceptionally Focuses with center autoclavable handle smooth focus switch, and Supplied with control box including on/off for Durable, aesthetic arm system that is recognized drift-free, trouble-free operation 5-year limited warranty / / IEC 60601-1-2 / IEC 60601-1 UL 60601-1 IEC 60601-2-41 CAN/CSA C22.2 No. 601.1 CE marked • • • • • • • continuous intensity adjustment • • • • • Lights APEX Major Surgical These high quality lights are offered in combination units with one each of the Outpatient® II and the CoolSpot™ II. Select from either a fleximount ceiling mount or a Fastrac™ and Double Trolley. For complete details on the lights, please see pages 96 and 97. Outpatient SURGICAL LIGHTS LIGHTS SURGICAL

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EQUIPMENT 98 SURGICAL PREPARATION

Certain products are needed to get animals prepared and ready for surgery. These products include fur removal products, identification products and animal weighing products. Harvard Apparatus offers several options within each of these categories to meet your application needs.

PRODUCT PAGE

Trimmers & Clippers...... 100-103 Vacuum Clipper System...... 104 Identification...... 105-106 Ear Tags...... 105 Ear Punches...... 105 Tattoo Systems & Pigment...... 106 Triple-Beam Balance...... 107 Battery Operated Portable Scale...... 107 Animal Weighing System...... 108 SURGICAL PREPARATION SURGICAL TRIMMERS & CLIPPERS PREPARATION SURGICAL

Mini Cord/Cordless Small Animal Trimmer

• Compact and lightweight • Optional cord or cordless operation • Cool running, no spray coolant needed

This professional quality trimmer is super convenient and suitable for all your small animal fur removal needs. The powerful yet quiet rotary motor runs at 6,000 rpm and does not require a spray coolant. This Trimmer offers convenient cord or cordless operation to provide constant trimming power so you will always have a fully charged trimmer ready for use. ChroMini™ Cordless Clipper The trimmer comes complete with rechargeable trimmer, charging line cord, two plastic reversible attachment guides, cleaning brush • Cordless operation and oil. • Lightweight • Simple & easy to use Order # Product ST1 72-6110 Mini Cord/Cordless Trimmer, 6.5 W, 120 VAC, 60 Hz This clipper is ideal for removing fine hair from laboratory animals ST1 72-6111 Replacement Size 30 Blade for Mini Cord/Cordless without hurting delicate skin. It combines unbeatable cutting performance and cordless operation. This permits you to achieve the results that professionals demand. The clipper features a superior quick detachable blade. Sterling Cordless Clipper This clipper comes complete with rechargeable/cordless trimmer, charger stand, detachable #30 blade, cleaning brush, oil, snap on Ideal for clipping small animals, guide comb, and instruction book. the Sterling Clipper is supplied with a standard blade, and Order # Product recharging unit. Blades are easily changed with a snap ST1 72-9063 ChroMini Cordless Clipper, 115 VAC, 60 Hz on/off movement. Available ST1 72-9064 Replacement Size 30 Blade, for ST1 72-9063 with a left hand or right hand ST1 34-1414 ChroMini Cordless Clipper, 230 VAC, 50 Hz grip to suit the individual user. ST1 34-1418 Replacement Size 30 Blade, for ST1 34-1414

Order # Product ST1 34-0245 Sterling Cordless Clipper, 230 VAC, 50 Hz ST1 34-0246 Replacement Blade – Standard ST1 34-0247 Replacement Blade – Fine

ChroMini is a trademark of Wahl Clipper Corporation.

100 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com TRIMMERS & CLIPPERS

Contura™ Cordless

Clipper SURGICAL PREPARATION This new design (replaces the Minicut) has been developed ergonomically for ease of Stylique® Cordless Trimmer handling when clipping. Giving a close shave, it is ideal for • Narrow blade ideal for small animals small animal preoperative • Slim, space-saving design use. Supplied with blade and recharging stand. • Lightweight

The Stylique® Cordless Trimmer is ideal for use on small laboratory Order # Product animals. The slim pencil shape and narrow blade design allows ST1 34-0243 Contura™ Cordless Clipper, 230 VAC, 50 Hz accurate and precise fur removal – perfect for prepping animals for ST1 34-0244 Replacement Blade for Contura Clipper, Fine surgical procedures. On larger animals, use this trimmer on more delicate areas such as the feet, face and ears. Blade is made of high carbon precision ground steel. The trimmer comes complete with size 30 Blade, 1-AA battery, blade guard, oil, built-in cleaning brush and instructions.

Specifications Dimensions, H x W x D 24.1 x 8.4 x 6.4 cm (9.5 x 3.3 x 2.5 in) Weight 0.14 kg (0.3 lb)

Order # Product ST1 72-9065 Stylique® Trimmer ST1 72-9066 Replacement Blade, Size 30, ⅜ in

Stylique is a registered trademark of Wahl Clipper Corporation. Contura is a trademark of Wella.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 101 TRIMMERS & CLIPPERS

ST1 72-6114 ST1 52-5204 PREPARATION SURGICAL

Two-Speed Small Animal Clipper Oster® Golden A5® Single Speed Small Animal Clipper • Powerful and fast • Quiet, lightweight and durable • Powerful yet small universal motor • Cool running • Up to 2100 SPM • Impact resistant • Provides coarse and fine clipping • Insulated face plate for cooler running operation This Two-Speed Small Animal Clipper is great for both light and heavy-duty jobs on all types of animals including dogs and cats. • Storage case included Special features include a snap-off air filter for easy cleaning, sealed This is the finest heavy-duty clipper available. Its powerful universal switch, and protective blade gasket with a sixteen foot professional motor runs at high RPMs and has a unique gear-down assembly. grounded power cord. The clipper comes complete with size 10 This feature gives the clipper greater power for its small size. blade, cleaning brush, lubricating oil, and instruction manual. New larger sized air intake/exhaust openings permit the clipper to run 20°F cooler than previous clipper models. Supplied with interchangeable blades, this clipper can cut through heavy fur Order # Product quickly and then shave down to bare skin neatly. ST1 72-6114 Two-Speed Small Animal Clipper, 115 VAC, 60 Hz The Cryogen-X™ blades are manufactured from fine grain, high Replacement Blades carbon steel. The cutting teeth are machined to exact dimensions ST1 72-6113 Size 50 Ultra Fine, Closeness of cut 0.40 mm (0.016 in) for the most precise cutting, and the blades are cryogenically ST1 72-6112 Size 40 Fine, Closeness of cut 0.6 mm (0.024 in) treated for additional wear resistance. No tools are necessary to ST1 72-6106 Size 30 Medium, Closeness of cut 0.8 mm (0.031 in) change the blades. The clipper has a double insulated twelve foot ST1 72-6107 Size 10 Fine, Closeness of cut 1.8 mm (0.071 in) cord, is UL listed and meets OSHA and CSA specifications. ST1 72-6108 Size 9 Fine, Closeness of cut 2 mm (0.079 in) Supplied complete with two blades, size 10 and 40, lubricating oil, ST1 72-6109 Size 8.5 Fine, Closeness of cut 3 mm (0.118 in) grease, cleaning brush, extra set of brush and spring assemblies. Options This popular, quiet, cool-running clipper has a range of 18 different ST1 52-9703 Lubricating Oil, ⅓ oz tube blades, sold separately on page 103.

Order # Product ST1 52-5204 Golden A5 Small Animal Clipper, 115 VAC, 60 Hz ST1 34-0207 Golden A5 Small Animal Clipper, 220/240 VAC, 50 Hz Replacement Cryogen-X™ Blade 1 ST1 72-9946 Size 10, Coarse, Closeness of Cut 1.6 mm (⁄16 in) 1 ST1 72-9958 Size 40, Fine, Closeness of Cut 0.25 mm (⁄100 in) Options ST1 52-5208 Spare Maintenance Kit. Includes Lubricating Oil, ½ oz tube, Clipper Grease, 1-¼ oz tube and a Cleaning Brush ST1 72-0481 Blade Wash, two 16 oz cans supplied ST1 72-0480 Blade Lubricant, two 16 oz cans supplied

Ostar and Golden A5 are registered trademarks of Sunbeam Products, Inc.

102 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com REPLACEMENT BLADES

ST1 72-9945 ST1 72-9946 ST1 72-9947 ST1 72-9948

ST1 72-9949 ST1 72-9950 ST1 72-9951 ST1 72-9952 SURGICAL PREPARATION

ST1 72-9953 ST1 72-9954 ST1 72-9955 ST1 72-9956

ST1 72-9957 ST1 72-9958 ST1 72-9959 ST1 72-9960

Oster® Golden A5® Replacement Order # Product Cryogen-X™ Blades ST1 72-9945 Size 4, 9.5 mm (⅜ in), Lamb Trim with Slightly Longer Coat 1 ST1 72-9946 Size 10, 1.6 mm ( ⁄16 in), Head, Face, Feet or sensitive skin Cryogen-X™ Blades are manufactured from fine grain, high carbon 1 ST1 72-9947 Size 5/8, 0.8 mm, ( ⁄32 in) steel. The cutting teeth are machined to exact dimensions for the ST1 72-9948 Size 5F, 6.3 mm (¼ in), Short Lamb Trim most precise cutting, and the blades are cryogenically treated ST1 72-9949 Size 5, 6.3 mm (¼ in), Short Lamb Trim for additional wear resistance. No tools are necessary to change 3 Size 15, 1.2 mm ( ⁄64 in), Face, Feet, Tails in pet trim the blades. ST1 72-9950 1 ST1 72-9951 Size 7/8, 0.8 mm ( ⁄32 in) ST1 72-9952 Size 7F, 3.2 mm (⅛ in) ST1 72-9953 Size 7, 3.2 mm (⅛ in) 1 ST1 72-9954 Size 30, 0.5 mm ( ⁄50 in), Face, Feet & Tail in Show Trim 5 ST1 72-9955 Size 9, 2 mm ( ⁄64 in), Thick Matted Coats & Close Stripping 1 ST1 72-9956 Size 50, 0.2 mm ( ⁄25 in), Very fine surgical use 7 ST1 72-9957 Size 8.5, 2.8 mm ( ⁄64 in), Terrier Body 1 ST1 72-9958 Size 40, 0.25 mm ( ⁄100 in), Surgical Use ST1 72-9959 Size 4F, 9.5 mm (⅜ in) 3 ST1 72-9960 Size 10W, 2.4 mm ( ⁄32 in), Light Horse

Cryogen-X is a trademark of Sunbeam Products, Inc.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 103 VACUUM CLIPPER

Vacuum Clipper System Detail of Vacuum ST1 59-8740 Clipper Shield PREPARATION SURGICAL

The vacuum cleaner has a HEPA exhaust filter which is 99.97% efficient at 0.3 microns. Debris is collected in a bag filter which is removed under negative pressure. This further reduces exposure to dander while emptying the vacuum cleaner. The vacuum’s swing arm rotates 360 degrees which allows the system to be placed away from the operator while being used. A sturdy, lightweight cart is supplied with the system for easy transport. The ST1 52-5204 Small Animal Clipper, described on page 102 is included with this system. This clipper mounts on the end of a lightweight hose 1.9 cm (0.75 in) diameter by 152.4 cm (60 in) long. Clipped hair and dander is suctioned past the clipper shield, into the hose, and then ends up in the bag filter internal to the vacuum. This process reduces hair and dander in the air and facilitates lab cleanup. The system is supplied complete with a paper bag, a cloth filter and HEPA exhaust filter. Replacement paper bags and HEPA filters are offered separately. An optional Tool Kit is also available separately. This kit contains some standard vacuum cleaner attachment tools which allow the vacuum to be used for general lab cleanup (dry only).

Order # Product Vacuum Clipper System ST1 59-8740 Vacuum Clipper System, 115 VAC, 60 Hz ST1 59-8737 Replacement Paper Bags, pkg. of 10 • For dander-free animal clipping ST1 59-8742 Replacement HEPA Exhaust Filter, pkg. of 1 • Ideal for researchers who are sensitive or allergic to ST1 72-0482 Replacement Cloth Filter, pkg. of 1 animal dander ST1 72-0483 Tool Kit • Clipper and vacuum in one saves cleanup time

This Vacuum Clipper System removes dander and animal hair during clipping, protecting operators who are sensitive or allergic to these materials. It is made up of three components: 1. Clipper shield 2. Vacuum cleaner with cart 3. Small animal clipper The unique clipper shield weighs 104.9 g (3.6 oz). It mounts directly behind the blades and will not interfere with the operator’s view. Both attachment and removal of the shield from the clipper is easy, facilitating cleaning and decontamination. The airflow across the clipper blades eliminates overheating and the need for a cooling spray.

104 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com IDENTIFICATION

Standard Laser etched ST1 34-0193 Applicator ST1 34-0194

Small Animal Ear Tags and Applicator Miniature Brass Ear Tags

• Suitable for mice Can be used for guinea pigs, rats, moles and other small species. They are not suitable for mice. Tags are supplied numbered • Custom order tags available consecutively in batches of 100. The Miniature Ear Tag Applicator is

These Ear Tags are for use with mice, rats and similarly sized required to secure the tag. Applicator sold separately. Prefix letters animals. Tags have a three digit numbering system. Supplied in are manufactured by special order only. packages of 500 numbered 001 to 500 or 501 to 1000. Other number sequences are available by special order. The Applicator is Order # Product required to secure the tag. Applicator sold separately. ST1 34-0194 Miniature Ear Tag Applicator SURGICAL Laser etched ear tags may be special ordered if unique ST1 34-0193 Miniature Brass Tags, numbered 1 to 100* PREPARATION identification numbers or codes are required. Custom tags may ST1 34-0935 Miniature Brass Tags, numbered 101 to 200* also include special characters. Please call for more details. ST1 34-0936 Miniature Brass Tags, numbered 201 to 300* ST1 34-0937 Miniature Brass Tags, numbered 301 to 400* Order # Product ST1 34-0938 Miniature Brass Tags, numbered 401 to 500* ST1 52-4716 Small Animal Ear Tags, pkg. of 1 to 500 * Note: Requires ST1 34-0194, see above. ST1 52-4718 Small Animal Ear Tags, pkg. of 501 to 1,000 ST1 52-4717 Applicator for Small Animal Ear Tags

Ear Punch

This easily operated hole punching device is suitable for marking small rodents whenever a permanent identification system is required. Two types of punches are available. A forcep type which provides a longer handle for gripping, or the simple thumb type. Two forcep type punches are available, select either 1.5 or 2.0 mm hole. Three thumb type punches are available, select either 1.0, 1.5 or 2.0 mm hole. These Punches are supplied individually. Biopsy Ear Punch Order # Product The Biopsy Ear Punch has a dual cutting edge that cuts rather than ST1 34-0136 Forceps Type Punch, 1.5 mm Hole tears, minimizing tissue trauma. This design makes this an ideal tool ST1 34-0137 Forceps Type Punch, 2.0 mm Hole for biopsy collection or earmarking of laboratory animals. The Biopsy ST1 34-0138 Thumb Type Punch, 1.0 mm Hole Ear Punch is available with a tube holder allowing for hands-free ST1 34-0139 Thumb Type Punch, 1.5 mm Hole sample collection. Gap sizes are available for mouse (1.5 mm) and rat ST1 34-0140 Thumb Type Punch, 2.0 mm Hole (2.5 mm) models.

Order # Product ST1 34-1061 Biopsy Punch with 1.5 mm Gap ST1 34-1175 Biopsy Punch with 1.5 mm Gap with Tube Holder ST1 34-1197 Biopsy Punch with 2.5 mm Gap ST1 34-1198 Biopsy Punch with 2.5 mm Gap with Tube Holder

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 105 IDENTIFICATION

ST1 72-0464 Tattoo Set PREPARATION SURGICAL

Tattoo Set

• Permanent identification of rodents, primates, dogs, fish, etc. • Easy operation

Micro-Tattooing System This Tattoo Set can be used on a variety of animals such as rodents, primates, dogs, fish, etc. You can easily mark ears, bellies, thighs, • Ideal for mice, rats, guinea pigs and other small animals tails, etc., with numbers or symbols large enough to be seen from • Permanent mark is easily readable on pigmented or a distance. albino animals This Tattoo Set is supplied complete with tattoo machine, storage • Rapid and easy to apply box, allen key set, spare spring set (front and back springs), • Inexpensive wall plug DC power source, on/off footswitch, 2 tubes, 10 needles • May be used on newborns (4 x 3.1, 4 x 5.2 and 2 x 8.3), six 0.5 oz containers of ink (5 x black and 1 x red), 100 inkcups, grommets and rubber bands. • Sterile and disposable hypodermic needles prevent the spread of potentially infectious disease Order # Product This tattooing system is a quick, efficient and affordable method of ST1 72-0464 Tattoo Set, 120 VAC permanently identifying laboratory animals, particularly mice and * Note: All three sizes (3.1, 5.2 and 8.3) can be used with rodents as well as rats as early as one day old. Designed and tested by laboratory large animals. The only difference between the needles is in the thickness of animal technicians, the system utilizes a hypodermic needle at one the letter or number produced. Size 8.3 will produce the thickest imprint of end of a stainless forcep and a small metal cup containing the Green the 3 sizes supplied. Tattoo Paste at the other side of the forcep. By squeezing the forcep together, the needle penetrates the toe/ Tattooing Pigment foot pad, ear or tail of the animal and injects a deposit of green paste into the animal. This method is humane, permanent, rapid, This tattooing pigment is available in five colors and is supplied in a economical, and allows unique identification of large numbers 2 ounce bottle. of rodents. A complete kit includes one micro-tattoo instrument, 1 oz tube Order # Product of green tattoo paste, one stainless steel planchette, one plastic ST1 72-9381 Black Tattoo Pigment holding case and two test hypodermic needles. ST1 72-9382 Red Tattoo Pigment ST1 72-9383 Blue Tattoo Pigment Recommended hypodermic needle size: ST1 72-9384 Green Tattoo Pigment - Young mice: 30 Gauge, ½ inch ST1 72-9385 Yellow Tattoo Pigment - Adult mice: 27 Gauge, ½ inch ST1 72-9386 White Tattoo Pigment - Rats and others: 25 Gauge, ⅝ inch

Order # Product ST1 72-7640 Animal Micro-Tattoo System, Complete Kit ST1 72-7641 Green Tattoo Paste, 1 oz, pkg. of 1 ST1 72-7642 Green Tattoo Paste, 5 oz, pkg. of 1

106 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com SCALES & BALANCES

Triple-Beam Balance Battery-Operated Portable Scale

Triple-Beam Balance Battery-Operated Portable Scale SURGICAL

• Three notched and tiered beams with center reading • Ideal for weighing small rodents directly in animal room PREPARATION • Spring-loaded zero adjust compensator • Bright, easy-to-read LCD display • Rugged and portable • Battery operated • Optional animal container The Triple Beam Balance features three notched and tiered beams with center reading and spring-loaded zero adjust compensator and This compact scale provides total portability in a durable, easy-to- a stainless steel plate. clean housing. This scale features simple, one button operation with This balance provides the convenience of a top loading balance a high contrast LCD display reading in grams or pounds: ounces. with the durability and versatility to accommodate a range of lab The scale runs on 3-AA batteries (included). applications, making it ideal for measuring solids, liquids, powders Available in three capacities. and animals.

The balance is available in three options: with a Stainless Steel Specifications Scoop only, with a Plastic Animal Basket only or with a Plastic Capacity 200 g 2,000 g 5,000 g Animal Basket and weights. The Weight Set (two 1000 g and one Readability 0.1 g 1.0 g 1.0 g 500 g is also available separately. Accuracy (%)* ±0.75 ±0.35 ±0.35 Weighing Modes g, lb, oz Stabilization Time ~3 sec Specifications Tare Range To capacity by subtraction Capacity without 610 g Operating 18° to 25°C (64° to 75°F) Attachment Weights Temperature Range Capacity with 2,610 g Dimensions: Attachment Weights Platform Size, 14.6 x 13.3 cm (5.75 x 5.25 in) Sensitivity 0.1 g L x W Calibrations: Balance Housing, 3.9 x 13.5 x 19.3 cm (1.5 x 5.3 x 7.6 in) Front Beam 10 x 0.1 g H x W x D Center Beam 500 x 100 g Weight 0.47 kg (11 lb) Rear Beam 100 x 10 g * Note: Percentage actual load or ±3 counts, whichever is greater. Dimensions, H x W x D 15 x 47 x 18 cm (6 x 18.2 x 7.1 in) Weight 3.2 kg (7 lb) Order # Product ST1 72-4585 Portable Electronic Scale, 200 g Capacity Order # Product ST1 72-4586 Portable Electronic Scale, 2,000 g Capacity ST1 72-4597 Triple-Beam Balance with Plastic Animal Basket ST1 72-4587 Portable Electronic Scale, 5,000 g Capacity and weight set ST1 72-4594 AC Adapter, 220/240 VAC, 50/60 Hz - European plug ST1 51-3754 Triple-Beam Balance with Stainless Steel Scoop only ST1 72-4595 AC Adapter, 240 VAC, 50/60 Hz - UK plug ST1 51-3746 Triple Beam Balance with Animal Basket only ST1 72-4596 AC Adapter, 240 VAC, 50/60 Hz - Australian plug (no weights included) ST1 72-4592 1044 ml Small Animal Container, ST1 72-8323 Plastic Animal Basket with Lid H x W x D, 6.4 x 12.7 x 14.7 cm (2.5 x 5 x 5.8 in) ST1 51-3745 Weight set ST1 72-4593 AC Adapter, 110/120 VAC, 50/60 Hz, US Plug

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 107 BALANCES

Animal Basket Animal Weighing Balance This simple, plastic lightweight basket is used to hold the animal while weighing. Simply place the basket with lid on the balance and use the tare feature. Next, take the basket to actually retrieve your animal and transport it from its cage to the balance. The basket lid keeps the animal from escaping. It also helps keep your balance clean. The basket measures 22.9 cm (9 in) in diameter and is 15 cm (6 in) high. This system includes the balance, plastic animal basket, dot matrix printer and one roll of paper.

Optional Software Kit The Labtronics Balance Talk software is for those people who simply PREPARATION

SURGICAL want to turn on their computer and begin collecting data. This software kit, utilizing Labtronics Balance Talk software, is a unique solution for your balance data collection, analysis, storage, and reporting needs. The software is available for trial by download.

Specifications Weighing Mode Dual weighing modes Weighing Ranges 1,000 g 3,000 g Readability 0.01 g 0.1 g Animal ±0.01 g ±0.05 g Containment Repeatability (std dev) Basket Linearity ±0.015 g ±0.05 g Stabilization Time ~3 sec Dimensions: Pan Size 16.5 cm (6.5 in) circular Balance Housing, 8.3 x 19 x 28.6 cm (3.25 x 7.5 x 11.25 in) H x W x D

Order # Product ST1 72-8324 Complete Animal Weighing System, 115 VAC, 60 Hz ST1 72-8325 Complete Animal Weighing System, 220 VAC, 50 Hz ST1 72-1361 Animal Weighing Balance Only, 115 VAC, 60 Hz Animal Weighing System ST1 72-1391 Animal Weighing Balance Only, 220 VAC, 50 Hz • Ideal for live animal weighing ST1 72-1364 Dust Cover for Balance ST1 72-8323 Plastic Animal Basket with Lid • Automatic calibration • ISO 9000 registered, CE marked • Optional software kit available

This complete Animal Weighing System is essential when extremely accurate animal weight measurements are needed. The microprocessor-controlled balance is dual range with readabilities down to 0.01 grams. Standard features include live animal weighing and RS-232 data interface with selectable baud rates. An accurate animal weight is obtained using the time averaging mode. This mode also has a reset function allowing you to arrive at the final weight reading in seconds rather than minutes with just the push of a button. This high performance balance can also be used for many other applications with these other standard features: GLP/GMP/ISO compatibility, automatic calibration programs, percent weighing, automatic zero tracking, system checkout sequencing, built-in security bracket, stability indicator, capacity tracker, below balance weighing for specific gravity determination, microprocessor control, exclusive real-time temperature compensation software, parts counting, user selectable vibration filtering, floating tare, and auto-ranging.

108 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com DELIVERY & SAMPLING

Harvard Apparatus is the infusions solutions expert with over 102 years of experience in physiological fluidics. From the needs of our customers we have created a line of totally integrated delivery and sampling systems including pumps, swivels, tethers, catheters and cages. We have carefully selected the highest quality components to work seamlessly together to meet the demanding needs of life sciences, pre-clinical and small animal studies. This experience and the ability to offer integrated solutions has led to peer endorsement. We have many publications, which are available for your review in the technical library on our website

PRODUCT PAGE

Animal Infusion Guide...... 110 Infusion Cage...... 111 Swivels...... 112-115 Stainless Steel Swivels...... 112-113 Plastic Disposable Swivels...... 114 Multi-Channel Swivels...... 115 Tethers...... 116-119 NEW Vascular Access Harnesses for Rats and Mice...... 116-117 NEW Vascular Access Buttons for Rats and Mice...... 118 Magnetic Head Block Tether for Rats and Mice...... 119 Glass Ionomer Cement...... 119 Swivel Mounts...... 120-121 Catheters...... 122-125 Intrathecal Catheter System...... 122 FunnelCath Mouse Catheter...... 122 Micro-Cannula...... 123 SoloCath Catheters...... 124-125 NEW Tubing and Connectors for Infusion...... 123, 126-127 Butterfly Infusion Sets...... 128 Catheter Introducers...... 128 Jackets...... 129-131 Collars...... 129 Sling Suits and Frames...... 132 Restraint Unit...... 133 NEW Metabolic Cages, Stands & Racks...... 134-138 Dosing Catheters...... 139 Portex Catheters...... 139 Dosing Gags...... 139 NEW Animal Feeding Needles...... 140-142 Needles...... 142-148 Vascular Occluders...... 149

Vascular Access Ports & Accessories...... 150-152 & SAMPLING DELIVERY Huber Needles & Sets...... 153 Drug Delivery Capsules...... 154-155 ANIMAL INFUSION GUIDE

Infusion Systems Microdialysis

With any tethered animal infusion there are certain pieces of Harvard Apparatus provides the liquid swivels, head block tethers equipment that are required. and counter balanced lever arms that have made microdialysis on freely-moving rodents possible. Our range of syringe pumps will Rat Continuous Infusion deliver the smooth, low-flow rates required for microdialysis. These systems require the same basic equipment as standard infusion applications. These systems are compatible with probes, fraction Continuous intravenous infusion of rodents is the most common collectors and other accessories from Harvard Apparatus and application for Harvard Apparatus delivery equipment. other sources. These systems provide unobtrusive continuous fluid access to the animal. These systems open up a range of applications beyond Typical System for Rat Microdialysis drug infusion, including blood sampling, blood pressure monitoring, System For Complete enteral feeding and bile duct access. Components Order # Description Description Swivel ST1 72-0000 Low-Torque Dual Channel See Page 112 Typical System for Rat Infusion Quartz-Lined Stainless System For Complete Steel Swivel Components Order # Description Description Swivel Mount ST1 61-0023 6 in Counter-Balanced See Page 120 Swivel ST1 61-0014 22 ga Single Channel Plastic See Page 114 Lever Arm for Rats Swivel Tether ST1 72-4476 Magnetic Head Block See Page 119 Swivel Mount ST1 61-0023 6 in Counter-Balanced See Page 120 Tether for Rats Lever Arm for Rats Tubing/ ST1 72-4426 CO-EX™ PE/PVC Tubing for See Page 123 & SAMPLING

DELIVERY Tether/ ST1 75-0068 Vascular Access Harness See Page 116 Connections 22 ga Swivels, Non-Sterile Harness for Rats with round-tip Syringe Pump ST1 70-4506 Pump 11 Pico Plus Elite See Page 113 3 Fr Pu Catheter included Caging ST1 72-0019 Rat Infusion Cage, Pellet See Page 111 Tubing/ ST1 72-4426 CO-EX® PE/PVC Tubing for See Page 123 Feeder & Water Bottle Connections 22 ga Swivels, Non-Sterile

Syringe Pump ST1 70-3005 PHD ULTRA™ Dual Syringe See Page 113 Pump, Infusion Only Typical System for Mouse Microdialysis Caging ST1 72-0019 Rat Infusion Cage, Pellet See Page 111 System For Complete Feeder & Water Bottle Components Order # Description Description Swivel ST1 72-0000 Low-Torque Dual-Channel See Page 112 Quartz-Lined Stainless Mouse Continuous Infusion Steel Swivel Swivel Mount ST1 61-0024 3.5 in Counter-Balanced See Page 120 Harvard Apparatus offers the broadest range of equipment for Lever Arm for Mice the growing field of mouse infusion. With mice, the quality of the Tether/ ST1 72-4477 Magnetic Head Block See Page 119 equipment you use is more important than ever; the swivel must Harness/Jacket Tether for Mice have very low rotational friction, the lever arm/swivel mount must Tubing/ ST1 72-4426 CO-EX™ PE/PVC Tubing for See Page 123 respond to every movement, and the catheter must be small, Connections 22 ga Swivels, Non-Sterile flexible and biocompatible. Syringe Pump ST1 70-4506 Pump 11 Pico Plus Elite See Page 113 Caging ST1 72-0016 Mouse Infusion Cage, Pellet See Page 111 Feeder & Water Bottle Typical System for Mouse Infusion System For Complete Components Order # Description Description Swivel ST1 72-6121 25 ga Single Channel See Page 114 Plastic Swivel Swivel Mount ST1 61-0024 3.5 in Counter-Balanced See Page 120 Lever Arm for Mice Tether/ ST1 75-0065 Vascular Access See Page 116 Harness Harness™ for mice Tubing/ ST1 72-6122 CO-EX™ PE/PVC Tubing for See Page 123 Connections 25 ga Swivels, Non-Sterile Catheter ST1 72-4440 FunnelCath Tapered PU See Page 122 Catheter; Proximal 2 Fr/ Distal 1.2 Fr Syringe Pump ST1 70-3005 PHD ULTRA Dual Syringe See Page 113 Pump, Infusion Only Caging ST1 72-0016 Mouse Infusion Cage, Pellet See Page 111 Feeder & Water Bottle

Vascular Access Harness is a trademark of Instech Laboratories, Inc. CO-EX is a trademark of Solomon Scientific. PHD ULTRA is a trademark of Harvard Apparatus. FunnelCath is a trademark of Genesis Medical International, Inc.

110 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com INFUSION CAGE

Mouse Infusion System (all components purchased separately)

DELIVERY & SAMPLING

Rodent Infusion Cage Order # Product ST1 61-0046 Mouse Infusion Cage, polycarbonate, 21.6 cm (8.5 in) high • No sharp corners ST1 61-0048 Mouse Infusion Cage Cover • Tethers less likely to tangle ST1 72-0014 Mouse Infusion Cage with Pellet Feeder • Probes less likely to dislodge ST1 72-0015 Mouse Infusion Cage with Water Bottle • Durable polycarbonate for long life ST1 72-0016 Mouse Infusion Cage with Pellet Feeder and Water Bottle ST1 61-0047 Bottom Screen for Mouse Infusion Cage • Available for mice and rats ST1 61-0024 3.5 in Counter-Balanced Lever Arm for Mouse Infusion Cage Durable polycarbonate cages designed to house tethered rodents ST1 61-0042 Rat Infusion Cage, polycarbonate, 38.1 cm (15 in) high during short-term infusion and microdialysis experiments. Since ST1 61-0044 Rat Infusion Cage Cover the cage is round, tethers will not tangle as they sometimes can ST1 72-0017 Rat Infusion Cage with Pellet Feeder in shoebox-type cages. Also, animals are less likely to dislodge ST1 72-0018 Rat Infusion Cage with Water Bottle sensitive probes since there are no sharp corners. Handles at the ST1 72-0019 Rat Infusion Cage with Pellet Feeder and Water Bottle top make it easy to move the cage. ST1 61-0023 6 in Counter-Balanced Lever Arm for Rat Infusion Cage These animal cages are frequently used with Counter-Balanced Lever Arms. This cage is available in two sizes and can be supplied with any combination of feeders and water bottles. Pictured above is a complete animal infusion system featuring our PHD ULTRA™ Syringe Pump, ST1 72-0015 Mouse Cage with Water Bottle, Counter-Balanced Lever Arm, and a Stainless Steel Swivel. The pump, cage, swivel and lever arm are sold separately. Please visit our website www.harvardapparatus.com for a complete listing of our syringe pumps.

For Surgical Instruments, see pages 1-56. For Catheters, see pages 122 to 125. PHD ULTRA is a trademark of Harvard Apparatus.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 111 SWIVELS

ST1 61-0003

& SAMPLING Dual Channel

DELIVERY Swivel

ST1 56-1324 Single Channel Swivel

Instech Single and Dual Channel Dual Channel Swivels Stainless Steel Swivels A two channel swivel gives you the ability to infuse and withdraw simultaneously, to infuse on one channel while monitoring on the Key Features other, or to infuse on two lines independently. Dual channel swivels • Lifetime warranty on single channel swivels are a bit more delicate than single channel models, particularly the • Single and dual channel models available side channel. With proper care and use, dual channel swivels can last for many years. • Autoclavable single channel swivels The NEW ST1 75-0277 Low-Torque Dual Channel Swivel has a A swivel is a device that is inserted into the fluid path so that the design similar to the ST1 72-0000 Low-Torque Dual Channel Swivel infusion line can rotate as the animal moves. It is a critical part of for Microdialysis, but uses stainless steel tubing instead of quartz for any tethered animal infusion system. The fluid swivels have been in improved durability. It is intended for infusion and blood sampling laboratory use for forty years and have earned a reputation as the with mice. The OD is 22 gauge; the ID is equivalent to 25 gauge. finest in the industry. Microdialysis Swivels Harvard Apparatus offers a variety of complete infusion systems that contain the equipment you need to carry out an infusion study. For years, the ST1 61-0004 Dual Channel Swivel has been the Custom swivels available by special order. Call for details. industry standard for awake animal microdialysis. It features quartz lining on the center channel to minimize dead volumes and Single Channel Swivels reactivity with neurotransmitters. Otherwise it is the same as our ST1 72-0000 Low-Torque Dual Channel Swivel model, with torques Single channel stainless steel swivels are autoclavable and may be that are appropriate for rats but not mice. reused hundreds of times. Self-adjusting seals, at the heart of every swivel, actually improve with use. All stainless steel models include The newer ST1 72-0000 uses a completely different seal design with a universal swivel-to-tether clamp which mates with any of our two significant improvements: quartz lining on both the center and spring tethers. side channels, and extremely low frictional torque, making it the first dual channel swivel that can be used with mice. However, the Our standard models are typically used with rats and mice, but ST1 72-0000 model is more fragile than the ST1 61-0004 model and work with rabbits, guinea pigs, and with the (ST1 61-0026) strain often cannot be repaired if clogged or damaged. relief, large animals as well.

112 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com SWIVELS

Application Single Channel Swivels Dual Channel Swivels Microdialysis for ✓ Mice & Rats Microdialysis ✓ of Rats Standard Infusion ✓ ✓ of Mice Standard Infusion ✓ ✓ of Rats Blood Pressure ✓ ✓ Measurements Rapid Infusions ✓ ✓ IV Feeding ✓ ✓ Specifications Inlet & Outlet 20 22 25 20 22 22 22 22 Tube Gauge CO-EX™ External – ST1 72-4426 ST1 72-6122 – ST1 72-4426 ST1 72-4426 ST1 72-4426 ST1 72-4426 Tubing Intra-Vascular – ST1 72-4429 ST1 72-6130 – ST1 72-4429 ST1 72-4429 ST1 72-4429 ST1 72-4429 Polyurethane Tubing PolyE Polyethylene ST1 59-8330 – – ST1 59-8330 – – – – Tubing

Center Channel ID 0.58 mm 0.41 mm 0.25 mm 0.58 mm 0.41 mm 0.15 mm 0.15 mm 0.25 mm (0.023 in) (0.016 in) (0.010 in) (0.023 in) (0.016 in) (0.006 in) (0.006 in) (0.010 in) Center Channel 16 µl 8 µl 3 µl 18 µl 8 µl 1.8 µl 1.4 µl 2 µl Dead Volume

Side Channel ID – – – 0.58 mm 0.41 mm 0.15 mm 0.41 mm 0.41 mm DELIVERY & SAMPLING (0.023 in) (0.016 in) (0.006 in) (0.016 in) (0.016 in) Side Channel – – – 18 µl 18 µl 3 µl 18 µl 4 µl Dead Volume Size (OD x L) 9.5 x 57.1 mm 9.5 x 57.1 mm 9.5 x 57.1 mm 9.5 x 60.4 mm 9.5 x 60.4 mm 9.5 x 60.4 mm 9.5 x 60.4 mm 9.5 x 60.4 mm (0.375 x 2.25 in) (0.375 x 2.25 in) (0.375 x 2.25 in) (0.375 x 2.38 in) 0.375 x 2.38 in 0.375 x 2.38 in 0.375 x 2.38 in 0.375 x 2.38 in Autoclavable Yes Yes Yes Yes Yes No Yes No Materials in SS,T SS,T SS,T SS,T (center) SS,T (center) Q,T (center) Q,T (center) SS,T (center) Fluid Path* SS,T (side) SS,T (side) Q,T,P,PM (side) Q,T (side) SS,T (side) Order # for Swivel ST1 61-0000 ST1 61-0001 ST1 56-1324 ST1 61-0002 ST1 61-0003 ST1 72-0000 ST1 61-0004 ST1 75-0277

* Note: SS is corrosion-resistant stainless steel (304 and 316); P is polysulfone plastic; T is PTFE;Q is fused silica quartz; PM is polyimide.

HARVARD APPARATUS SYRINGE PUMPS Harvard Apparatus Syringe Pumps are the perfect complement for Instech Swivels due to their high accuracy and legendary reliability. Single or Dual Syringe, Infusion Only, Infusion/Withdrawal or Programmable Models available. See our website www.harvardapparatus.com for our full line of syringe pumps.

Pump 11 Elite Series Syringe Pumps PHD ULTRA™ Series Syringe Pumps

• Ideal for Microdialysis • Ideal for Infusion Studies • Single and Dual Syringe • Dual Syringe • Infuse only and Infusion/Withdrawal • Infusion Only, Infusion/Withdrawal and Programmable

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 113 SWIVELS

Single Channel Configurations These disposable swivels are available in three sizes, with or without luer inlets. The swivel bodies are color-coded by gauge according to international standards. The 25 gauge swivel mates with standard PE20 catheter tubing and is ideal for the infusion of mice. The 22 gauge swivel is most commonly used with rats because it mates with standard PE50 catheter tubing. Use the 20 gauge version when working with more viscous solutions, or at higher flow rates. The 20 gauge swivel is ideal for use with rabbits and other animals of a similar size. These swivels are individually packaged and EtO sterilized. They include a plastic swivel-to-tether clamp for attachment to all of our without Luer Inlet standard spring tethers. with Luer Inlet Applications 20 Gauge 22 Gauge 25 Gauge Standard Infusion of Mice ✓ Standard Infusion of Rats ✓ Instech Precision Disposable Swivels Blood Pressure ✓ Measurement • 25 gauge swivel is ideal for mice Rapid Infusions ✓

& SAMPLING • Plastic swivel-to-tether clamp included

DELIVERY IV Feeding ✓ • Single use, low cost, precision swivels Specifications • Meets Harvard Apparatus’ and Instech’s Color Pink Blue Purple strict quality standards Inlet and Outlet 20 22 25 Tube Gauge • Available in 3 sizes: 20 gauge, 22 gauge and 25 gauge Compatible Tubing PE60, PE90 PE50 PE20 Introducing the first plastic swivel worthy of the Instech name. This Channel ID 0.58 mm 0.41 mm 0.25 mm single channel swivel has been designed for researchers that require (0.023 in) (0.016 in) (0.010 in) components touching the fluid path to be replaced frequently to Internal Dead Volume 12 µl 6 µl 2.5 µl avoid cross contamination. These plastic swivels are provided EtO Size: Diameter x Length 9.5 x 42.9 mm 9.5 x 42.9 mm 9.5 x 42.9 mm sterilized. They cannot be autoclaved. (0.375 x 1.69 in) (0.375 x 1.69 in) (0.375 x 1.69 in) Order # ST1 61-0011 ST1 61-0014 ST1 72-6121 Instech Quality on the Inside Order # (with Luer Inlet) ST1 72-4072 ST1 72-4074 - While we have used a polysulfone plastic body in order to reduce the price, we have made no compromises in terms of functionality. For Rodent Infusion Cages, see page 111. In fact, the critical internal components (the PTFE seal, the stainless steel seal cup, and the stainless steel spring) are common between these and our stainless steel swivels. As a result, these swivels feature our unique self-adjusting seals, which do not loosen with use (thereby preventing leaks) and have low rotational friction. This superior design has been proven reliable in many thousands of studies over the past 30 years. As with all Instech Swivels, fluids traveling through them touch only stainless steel hypodermic tubing and a PTFE seal. Internal dead volumes in these swivels are even lower than in our stainless steel swivels.

114 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com SWIVELS

To solve these problems the seals were kept tight on the Multi- Channel Swivel and a motor was added to assist the rotation. A controller senses the animal’s movement and drives the swivel core to follow the animal. Unlike switch-based systems, this swivel features a proportional control, allowing fine continuous movement to minimize stress on the animal. The torque felt by the animal is similar to that of an Instech Single Channel Swivel. This power- assisted proportional control technology was first introduced in 2000 in Instech’s patented Swivelless Swivel™, but is applied here to a swivel that hangs above caging of the researcher’s choice. The control unit mounts to the vertical portion of the counter- balanced arm and is powered by a 12 VDC adapter. The analog motor drive signal is available as an output for rotational activity monitoring. The Multi-Channel Swivel is counter balanced to minimize forces on the animal. While the power assist circuitry is responsive enough that a mouse can turn the swivel, use with mice is not recommended due to the negligible weight of the animal relative to the swivel.

Specifications Number of Channels 5 Dead Volume: Microdialysis 6-7 µl Channel

22 Gauge 15-20 µl DELIVERY Instech Multi-Channel Swivel Channel & SAMPLING Channel ID • Three standard configurations Microdialysis Channel 0.2 mm (0.009 in) • Five, low dead volume channels for microdialysis 22 Gauge Channel 0.4 mm (0.015 in) • Proportional control for fine continuous movement Channel OD 0.028 in (22 ga) • Minimal stress on animal Dimensions, 17.8 x 1.5 cm (7 x 0.6 in) Length x Diameter These remarkable swivels feature five low-dead-volume channels and rotational torque as low as that of our one-channel models. Order # Product There are three standard configurations available; one with all 22 ST1 72-6134 Powered Multi-Channel Swivel, 5 Channels, gauge infusion channels and two with a variety of combinations 4 Microdialysis and 1 x 22 ga Channel, pkg. of 1 of microdialysis channels (low dead volume and lined to protect ST1 72-9351 Powered Multi-Channel Swivel, 5 Channels, 2 Microdialysis and 3 x 22 ga Channels, pkg. of 1 neurotransmitters) and standard 22 gauge infusion channels. ST1 72-9162 Powered Multi-Channel Swivel, 5 Channels all 22 ga Channels, The practical limit on the number of lines in a traditional fluid swivel pkg. of 1 has been two; swivels with three or more channels are typically ST1 61-0052 Replacement Universal Swivel to Tether Clamp, pkg. of 5 impossible for a rodent to turn and can have large dead volumes or problems with cross-channel leakage.

Swivelless Swivel is a trademark of Instech Laboratories, Inc.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 115 TETHERS

Vascular Access Harness Instech Single Channel Vascular Access Harness™ for Rats

Install the ST1 72-9163 VAH™ Harness™ at the time of catheterization. For best results, use a 3 French polyurethane catheter as it makes the most reliable fit with the 22 gauge connector in the harness. A 25 cm (0.8 in) round-tip PU catheter, specially designed for the VAH™, is available bundled with the harness in part number ST1 75-0068. For intermittent access for bolus injection, blood sampling or flushing, pierce the septum manually using ST1 72-9166 VAH™ Septum Needle or ST1 72-9167 Male VAH™ Connector with luer inlet. For continuous access, connect to a VAH™ tether. The ST1 72-9165 Tether Assembly Kit includes the tether, a swivel and tubing with a luer stub to connect to a syringe pump. The NEW ST1 75-0291 Plug can be used to seal off the tether connector and keep it clean while the animal is disconnected.

Needle Order # Product ST1 75-0068 VAH™ for Rats with Round-Tip Catheter and Septum Needle, Sterile, supplied individually & SAMPLING

DELIVERY ST1 72-9163 VAH™ with Septum Cover and Septum Needle, Sterile, sup- plied individually ST1 72-9164 VAH™ Tether Assembly, Sterile, 30.5 cm (12 in), supplied Septum individually

ST1 72-9165 Tether Assembly Kit: ST1 72-9164 VAH Tether Assembly, ST1 72-4075 22 Gauge Plastic Swivel, 60.9 cm (24 in) CO-EX™ and Luer Stub, Sterile, supplied individually ST1 72-9166 VAH™ Septum Needle, Female Luer, 22 ga x 1.3 cm (0.5 in), Sterile, pkg. of 12 CatheterAttachment ST1 72-9167 Rat VAH™ Connector with Luer Inlet, 3 cm (1.2 in) tubing, pkg. of 12 Detail of VAH harness and tether attachment. ST1 75-0291 Plug for VAH™ Tether, pkg. of 10 Instech Vascular Access Harness™ Instech Single Channel Vascular Access • Septum permits aseptic technique Harness™ for Mice • Quick connection Just like the VAH™ for Rats, the new ST1 75-0065 VAH™ for Mice • Minimal backflow is installed at the time of catheterization. For best results, use • Animals can be ordered with VAH™ and catheter installed our specially designed 2 French catheter with a molded hub that connects to the 22 gauge tube in the harness port. A 4 cm (1.6 inch) • Low profile version, is available bundled with the harness in part number ST1 The Vascular Access Harness™ (VAH™), an advancement on the 75-0064. Contact us for other sizes. original Covance Infusion Harness, permits quick and aseptic For continuous access, connect a mating mouse VAH™ tether with connection and disconnection of a catheterized rat or mouse and an tubing that mates with 25 gauge swivels. When accessing the infusion tether. harness port directly to infuse, withdraw or check patency, use The VAH™ consists of a small external port (or two ports, in the case the ST1 75-0061 Connector rather than a septum needle for proper of the dual channel model) housed in a harness which is installed alignment and to avoid damage to the small septum. at the same time that the catheter is implanted. The catheter is attached to a connector built into the port under the harness dome. The port and catheter are filled with lock solution to maintain Order # Product patency during transport. ST1 75-0064 VAH™ for Mice with 2 Fr, 4 cm Catheter, Sterile, supplied individually (injection set not included) To begin an infusion or blood sampling study, simply remove the cap, ST1 75-0065 VAH™ for Mice, Sterile, supplied individually wipe the septum with disinfectant and plug the mating VAH™ tether (injection set not included) into the harness. A recessed septum-piercing needle built into the tether ST1 75-0062 VAH™ Assembly for Mice, 17.8 cm (7 in), supplied individually makes the fluid connection through the port. Like a subcutaneous ST1 75-0063 Tether Assembly Kit: ST1 75-0062 VAH™ Tether Assembly, access port, the VAH™ is a closed system; tether connection does not ST1 72-4076 25 ga Plastic Swivel, 60 cm (24 in) Co-EX™ introduce contamination or air. Furthermore, retrograde flow, which can Tubing and 25 ga Luer Stub, Sterile, supplied individually lead to occluded catheters, is virtually eliminated. ST1 75-0061 Mouse VAH™ Connector with Luer for Direct Access, All parts are supplied EtO sterilized. pkg. of 12 Vascular Access Harness and VAH are trademarks of Instech Laboratories, Inc. CO-EX is a trademark of Solomon Scientific.

116 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com TETHERS

Specifications for VAH™ Harness Single Channel Single Channel Dual Channel VAH™ for Rats VAH™ for Mice VAH™ for Rats No.Dual of Channel Channels Vascular 1 1 2 Access Harness™ Port Volume 8 µl 2 µl 8 µl Septum Durability ~200 sticks ~100 sticks ~200 sticks Saddle Size 2.9 x 2.9 cm 1.4 x 1.4 cm 2.9 x 2.9 cm (1.13 x 1.13 in) (0.56 x 0.56 in) (1.13 x 1.13 in) Body Surface 5.3 cm2 1.3 cm2 5.3 cm2 Contact Area (0.82 in2) (0.20 in2) (0.82 in2) Spring Type PS95 PS62 PS115 (Standard Length) 30 cm (12 in) 18 cm (7 in) 30 cm (12 in) Standard Belly 23 cm (9 in) 11 cm (4.5 in) 23 cm (9 in) Band Length Compatible ST1 61-0014 ST1 72-6121 ST1 61-0014 Instech Dual Channel Plastic Swivels Compatible ST1 61-0001 ST1 56-1324 ST1 61-0003, Vascular Access Stainless Swivels ST1 61-0001 ™ Harness for Rats Tether Tubing ST1 75-0296 ST1 75-0297 ST1 75-0296 Harness Connector 22 ga 22 ga 22 ga This Dual Channel Vascular Access Harness™ connects two Compatible Catheter 3 Fr 3 Fr, tapered 3 Fr independent fluid channels as Harness and 13 g 3 g 17 g

Tether Weight simply as the standard Vascular Access Harness™ connects one. Specifications for VAH with Round-Tip Catheter Bundled Order # ST1 75-0068 ST1 75-0064 ST1 75-0292 Install the ST1 72-4454 Dual Catheter Order # ST1 75-0298 ST1 75-0299 ST1 75-0298 Channel VAH™. For best results Material PU, uncoated PU, uncoated PU, uncoated DELIVERY use a 3 French polyurethane & SAMPLING Size 3 Fr** 2 Fr 3 Fr** catheter. Two 25 cm round-tip ID / OD 0.6 x 1.0 mm 0.3 x 0.6 mm 0.6 x 1.0 mm PU catheters, specially designed (0.025 x.040 in) (0.013 x.025 in) (0.025 x.040 in) for the VAH™, are available Distal Tip Round Round Round bundled with the harness in part number ST1 75-0292. Proximal End Trimmable PU hub for Trimmable 22 ga Access the ports directly using a ST1 72-9166 needle for manual Length 25 cm (9.8 in) 4 cm (1.6 in) 25 cm (9.8 in) injections, sampling or flushing. Suture Beads 1, moveable 1, moveable 1, moveable Connect the ST1 72-4456 VAHD Tether Assembly Kit for continuous Attachment Sleeve None None None access to one channel through a swivel and intermittent access to Packaging 3 x 7 in pouch 3 x 7 in pouch 3 x 7 in pouch the second channel through an injection port. Alternatively, connect the ST1 72-4455 Dual Channel VAH™ Tether to a ST1 61-0003 Dual ** Approximately 10% larger ID/OD than standard 3 Fr PU SoloCath™ . Channel Swivel for continuous access to both channels.

Order # Product ST1 75-0292 Dual Channel VAH™ with 2 Round-Tip Catheters and Septum Needle, Sterile, supplied individually ST1 72-4454 Dual Channel VAH™ with Septum Needle, Sterile, supplied individually ST1 72-4455 Dual Channel VAH™ Tether Assembly, 30.5 cm (12 in), Sterile ST1 72-4456 VAHD Tether Assembly Kit: ST1 72-4455 Dual Channel VAH™ Tether Assembly, ST1 72-4070 Mini Tube Injection Port 22 ga x 4 mm, ST1 61-0014 22 gauge Single-Channel Plastic Swivel, 60 cm (24 in) CO-EX™, ST1 72-4439 Luer Stub 22 ga, Sterile, supplied individually ST1 75-0293 Protective Cap for VAHD Harness ST1 75-0294 Dual VAH™ with 1 Extra Injection Port and Septum Needle, Sterile, supplied individually ST1 75-0295 Dual VAH™ with 2 Extra Injection Ports and Septum Needle, Sterile, supplied individually ST1 72-9166 VAH™ Septum Needle, Female Luer, 22 ga x 1.3 cm (0.5 in), Sterile, pkg. of 12

Vascular Access Harness and VAH are trademarks of Instech Laboratories, Inc. CO-EX is a trademark of Solomon Scientific.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 117 TETHERS

ST1 75-0055 Tether Catheter VAB™ for Rats Connection Attachment and ST1 75-0057 for Rat VAB™ for Rat VAB™ VAB™ with Tether Assemby

ST1 75-0060 ST1 75-0060 VAB for Mice VAB™ for Mice and ST1 75-0062 VAB™ Tether Assembly

Button view

Top view

Button View Instech Vascular Access Button™ Silicone Septum & SAMPLING DELIVERY • Features an external port with a septum Polyester for closed system Surgical Felt • Ideal for long-term studies • Available for rats and mice

Button tethers are surgically implanted under the skin. In older Stainless models the catheter passes through an opening in the stalk of Steel the button through a spring tether and up to a swivel. The new Coupler Vascular Access Button™ (VAB™) features an external port with a Rigid Polyurethane Body septum to create a closed system. Compared to harnesses, buttons require a bit more work in surgery, however, there are no belly bands that require adjustment and with proper tissue ingrowth, Order # Product buttons can be a good option for long-term studies. VAB for Rats ST1 75-0055 VAB™ for Rats with Round-Tip Polyurethane Catheter and Vascular Access Button™ for Rats Septum Needle, Sterile, supplied individually ST1 75-0056 VAB™ for Rats with Septum Needle, Sterile, This implantable button features an external port with a septum supplied individually similar to the Vascular Access Harness™ for quick, aseptic ST1 75-0057 VAB™ Tether Assembly, 30.5 cm (12 in), Sterile, connection and disconnection of a catheterized rat and an infusion supplied individually tether. They are ideal for long-term infusion studies and intermittent ST1 75-0058 Tether Assembly Kit: ST1 75-0057 VAB Tether Assembly, infusion protocols such as IV self administration or blood sampling. ST1 72-4075 22 ga plastic swivel, 60 cm (24 in) Co-EX™ and ST1 72-4439 Luer stub, Sterile, supplied individually Compared to the Dacron® Mesh Button, the ST1 75-0056 Vascular Access Button™ features sturdier medical-grade polyester felt. ST1 75-0059 Protective Metal Cap for Rat VAB™ Attach a 3 French PU catheter (included with part number ST1 72-9166 VAH™ Septum Needle, 22 ga x 0.5 in, Sterile, pkg. of 12 ST1 75-0055) to a 22 gauge connector under the felt. The button is VAB for Mice implanted at the time of catheterization; to begin an infusion study ST1 75-0060 VAB™ for Mice, 22 ga, Sterile, supplied individually simply disinfect the septum and plug in the mating ST1 75-0057 ST1 75-0061 Mouse VAB™ Connector with Luer for Direct Access, pkg. of 12 Tether. The recessed septum-piercing needle will make the fluid ST1 75-0062 VAB™ Tether Assembly for Mice, 17.8 cm (7 in), Sterile, connection without exposing the fluid path to the environment. supplied individually Group housing is possible when not tethered if the optional ST1 75-0063 Tether Assembly Kit: ST1 75-0062 VAB™ Tether Assembly, ST1 75-0059 Protective Metal Cap is used. ST1 72-6121 25 ga plastic swivel, 60.9 cm (24 in) PU external infusion tubing, 25 ga Luer stub Vascular Access Button™ for Mice Like the VAB™ for rats, the new VAB™ for mice permits quick, aseptic connection and disconnection of a catheterized mouse and an infusion tether. The polyester surgical felt disk measures 14 mm in diameter. Catheters attach to a 22 gauge connector under the felt. Access the port built into the button directly using a syringe fitted with a mating injector, or connect a tether with a 25 gauge Vascular Access Button, VAB and Vascular Access Harness are trademarks of swivel for continuous access (ST1 75-0063 Mouse VAB™ Tether Kit). Instech Laboratories, Inc. Dacron is a registered trademark of E.I. du Pont de Nemours and Company. CO-EX is a trademark of Solomon Scientific.

118 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com TETHERS & CEMENT

ST1 72-4476 ST1 72-4477 Magnetic Head Magnetic Block, Spring Head Block, Tether Looped Wire Tether

Instech Magnetic Head Block Tether Instech Glass Ionomer Cement DELIVERY & SAMPLING for Rats and Mice This resin-based glass ionomer cement is ideal for permanent head This design uses magnets to connect the tether to a base that is attachment of microdialysis probes and head block tethers in rats attached to the skull using dental or glass ionomer cement. Simply and mice. It has significant advantages over the more commonly bring the two parts near each other and they will snap together. used methylmethacrylate cements. It bonds to bone, eliminating Tubing exits through a hole in the side of the connector. the need for bone screws in most cases. It has a lower temperature increase during polymerization and it hardens more quickly with no Designed for rats or mice, tethers are available either with noxious fumes. a protective PS95 spring or a lightweight looped wire. The ST1 72-4477 tether includes a special slotted clamp (replacement Our automixing configuration includes a dispenser, two 13.3 g part ST1 72-4084) for direct attachment to the outlet tube cartridges and 44 disposable mixing tips. The cartridges have two of our swivels, see pages 112-115. Use with a ST1 61-0023 or separate chambers so that the components of the cement are only ST1 61-0024 Counter-Balanced Lever Arm, see page 120. The mixed in the tips; therefore, they do not need to be used all at once. bases are provided sterile; other components are non-sterile. Also, they contain more than 80 times the volume of the 0.16 g single use capsules that we previously offered. An SOP for rodent head attachment is included. Sold for laboratory animal research Specifications applications only. Clear Lumen 2.3 mm (0.090 in) 1.8 mm (0.070 in) Tether Type PS95 Spring looped wire Order # Product Tether Length 30 cm (12 in) 30 cm (12 in) Glass Ionomer Cement Kit for Headblocks, Base Width 0.64 cm (0.25 in) 0.64 (0.25 in) ST1 72-9168 supplied individually Base Height 1.3 cm (0.5 in) 1.3 cm (0.5 in) ST1 72-9169 Replacement Glass Ionomer Cement Capsules, pkg. of 50 System Weight 7.5 g 1.0 g

Order # Product ST1 72-4476 Magnetic Head Block, Spring Tether, 1 base ST1 72-4477 Magnetic Head Block, Looped Wire Tether, 1 base, slotted clamp ST1 72-4478 Replacement Magnetic Head Block Bases, sterile, pkg. of 10 ST1 72-4479 Replacement Looped Wire Magnetic Tethers, non-sterile, pkg. of 5 ST1 72-4084 Replacement Slotted Swivel Clamp, pkg. of 5

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 119 SWIVEL MOUNTS

ST1 61-0023 ST1 72-4064 Counter-Balanced Lever Arm Single-Axis Lever Arms (swivel and animal container sold separately) (swivel and cage sold separately) & SAMPLING DELIVERY

Instech Counter-Balanced Lever Arm Instech Single-Axis Lever Arms

• Minimizes stress on microdialysis probes & animal This mount is designed for standard infusion of rats in shoebox • Unimpeded animal movement cages. The mount pivots in the vertical plane to remove slack from the tether but allows enough length to reach all corners of • Available for rats and mice an asymmetrical cage. The adjustable counter-weight can be set to balance the weight of our swivels plus a tether. The crossbar in Designed to minimize stress on microdialysis probes, the Counter- the wire top must be clipped in the slot that the tether is placed Balanced Lever Arm moves with the animal to prevent slack in the in for maximum travel. Supplied individually. For mouse work or tether. Most other lever arms use a mass as the counterbalance; microdialysis the more responsive Counter-Balanced Lever Arm is ours uses an adjustable spring, making it lighter and more recommended. responsive.

The mounting plate can be adjusted for mounting to the side or top Order # Product of many types of cages, including our ST1 61-0042 Animal Infusion ST1 72-4063 Single-Axis Lever Arm for Polysulfone Swivels Cage, see page 111. If you are using a shoebox-type cage, a counter- balanced lever arm can prevent the tether from tangling. ST1 72-4064 Single-Axis Lever Arm for Stainless Steel Swivels The ST1 61-0023 is a 6 inch arm that is typically used in studies with rats; the ST1 61-0024 is a 3.5 inch arm that is practically a requirement for any continuous infusion study involving mice.

Order # Product ST1 61-0023 6 in Adjustable Spring Counter-Balanced Lever Arm ST1 61-0024 3.5 in Adjustable Spring Counter-Balanced Lever Arm

120 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com SWIVEL MOUNTS

ST1 61-0018 ST1 72-4060 Swivel Bracket Mouse Micro-Isolator Cage Mount

Instech Swivel Bracket

This simple swivel bracket easily mounts to most screen and solid material cages. This bracket includes an additional backing plate and swinging tether support to mount the swivel horizontally on the front of the cage (a great benefit with cage rack systems).

Order # Product DELIVERY

ST1 61-0018 Swivel Bracket, Mounting Hardware, Backing Plate for Top or & SAMPLING Side Mounting, Swinging Tether Arm Instech Mouse Micro-Isolator Cage Mount

Now you can continuously infuse mice while maintaining a safe ST1 61-0021 micro-environment for your nudes and transgenics. This Micro- Fixed Swivel Mount Isolator Cage Mount is designed to attach to the standard micro- isolator cage (such as those made by Allentown Caging and Lab Products) with no modifications to the cage or cover. Simply remove the wire lid and install the swivel system. This Mount includes a spring counter-balanced lever arm attached to a bracket with holes to protect the IV lines as they enter and exit the cage. A feeder and water bottle are available separately.

Order # Product ST1 72-4060 Mouse Micro-Isolator Cage Mount ST1 72-4061 Feeder for Mouse Micro-Isolator Cages ST1 72-4062 50 ml Water Bottle for ST1 72-4060

Instech Fixed Swivel Mount for Tecniplast Metabolic Cages

This mount is supplied complete with new cage top. Swivel sold separately, see page 112.

Order # Product ST1 61-0021 Fixed Swivel Mount for Tecniplast Metabolic Cages

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 121 CATHETERS

Intrathecal Catheter FunnelCath™ Mouse Catheter

Intrathecal Catheter System, 32 Gauge

• Reduces catheter-induced histopathology • Polyurethane catheter material causes substantially less nerve injury compared to other catheter materials • For delivery of drugs to the brain • Ideal for rats and other small animals

This 32 gauge Intrathecal Catheter is the key component of a delivery system specifically developed for use in the rat and other small research animals. A significant advancement over the ™ standard polyethylene-based products generally used for such Solomon FunnelCath Mouse Catheter & SAMPLING

DELIVERY research, its material and size combine to produce a minimally • Allows easy catheterization of mice reactive device, thereby reducing catheter induced histopathology that could obscure other observations. • Permits attachment to a standard 25 gauge or 22 gauge swivel While studying the effects of intrathecally-injected anesthetics,

researchers at the University of California at San Francisco • Two sizes available: encountered morphologic – 1.2 French to 2 French for use with 25 gauge swivels changes apparently – 1.2 French to 3 French for use with 22 gauge swivels induced by the implanted • Extruded tube provides a seamless connection catheter. Micor was with no leaking! approached for its assistance in identifying The increase in catheterization of mice has brought to light a a material that could vexing problem: how to attach a tiny catheter to conventional reduce the nerve damage devices such as swivels and luer stubs. The solution is the that was observed. These innovative FunnelCath™. efforts suggested that 32 gauge polyurethane had FunnelCath™ is extruded from the same implant-grade the desired properties. polyurethane used in our SoloCaths, see page 124, though a (see graph.) Accordingly, bit stiffer to facilitate placement in mice. We offer two sizes: Nerve injury score for sections obtained 12 mm a study was conducted (1) a 2 French proximal end for attachment to a 25 gauge swivel, caudal to the conus medullaris, 7 days after an tapering down to a 1.2 French intravascular segment, and (2) a intrathecal infusion of normal saline. comparing catheters composed of this material 3 French proximal end for attachment to a 22 gauge swivel, also versus polyethylene or polyamide. Although sensory function tapering down to 1.2 French. did not differ significantly, nerve injury was substantially lower in Before the FunnelCath™ there were two ways of tapering a catheter. animals implanted with 32 gauge polyurethane catheters.1 The first involved “pulling down”, or stretching tubing using an This material is now incorporated into a commercially available open flame or hot oil. This method was cumbersome and the device, the 32 gauge Intrathecal Catheter System. This system catheters were inconsistent. The second method involved bonding a contains an 11.7 cm (4.6 in) catheter, a bonded connection assembly, smaller catheter to a larger one. Catheters produced this way were and a PTFE coated stylet to facilitate placement. It is individually typically vulnerable to breakage and leaks. The FunnelCath™ is the packaged and sterilized. first and only catheter tapered during the extrusion process, making it seamless and consistent catheter to catheter, batch to batch.

Order # Product These catheters are uncoated polyurethane with a clear, rounded distal tip. Individually packaged and sterilized. Sold in packages ST1 72-0484 Intrathecal Catheter System, 32 ga, pkg. of 1, Sterile of 5. Citation: 1. Sakura S, Hashimoto K, Bollen AW, Ciriales R, Drasner K: Intrathecal catheterization in the rat: Order # Product Improved technique for morphologic analysis of drug-induced injury. ANESTHESIOLOGY 1996; 85:1184-9 (Reprints of this report are available through Micor, Inc., upon request.) ST1 72-4440 FunnelCath™ Proximal 2 Fr / Distal 1.2 Fr, 60 cm, no beads, sterile, pkg. of 5 ST1 72-4441 FunnelCath™ Proximal 3 Fr / Distal 1.2 Fr, 60 cm, no beads, sterile, pkg. of 5

FunnelCath is a trademark of Genesis Medical Intervention, Inc. SoloCath is a trademark of Solomon Scientific.

122 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com CATHETERS

ST1 72-9030 Micro-Cannula CO-EX™ Tubing

Micro-Cannula

• For insertion in very small blood vessels Solomon CO-EX™ External Infusion Tubing • Can be used with radio labeled compounds

Protects sensitive This Micro-Cannula has been designed for quick and easy insertion compounds from: into the arteries and veins of small animals such as rats, mice and hamsters. The Cannula tip is contoured for easy insertion and is

• Absorption into tubing fitted with an adjustable shoulder or barb for “tie-in” to the animal • Evaporation through tubing to prevent accidental removal. The stainless steel trochar aids in fluid vascular penetration and allows for a maximum range of cannula • Leaching plasticizers path PE manipulation during insertion. • Kinked tubing DELIVERY PVC The Micro-Cannula tubing is made from a perflourocarbon material & SAMPLING CO-EX™ was developed to address the that is biocompatible. One end of the cannula has a female problem in drug infusion studies whereby compounds can be lost connection allowing convenient linkage to infusion lines. due to absorption into the tubing, evaporation through the tubing, This Micro-Cannula has been utilized effectively for the rapid or the tubing is altered due to the leaching of plasticizers from the cannulation of hamster carotid and femoral arteries and for the tubing. In humans, CO-EX™ is used to infuse insulin, nitroglycerine, cannulation of mouse carotid arteries. It has also been used as an and Taxol®– compounds which are not compatible with traditional “indwelling” catheter during experiments spanning an entire day. PVC infusion tubing. Projected uses include the injection of small amounts of expensive PE traditionally has been used for drug infusion studies. radiolabeled compounds or monoclonal antibodies intra-arterially, Unfortunately, PE is prone to kinking. CO-EX™ has PE on the ID fluid for more effective distribution to vital organs. It can also be used to path for compatibility and PVC on the OD which adds thickness to inject drugs directly into the circulation or to measure pressure in the tubing to minimize kinking. the femoral artery without compromising blood flow to the brain. CO-EX™ is designed to attach to commonly used 22 and 25 gauge These Micro-Cannulae are supplied individually in a non-sterile swivels and blunt cannula. It is ideal for attachment between swivels package of 1 or 50. With care, these Micro-Cannulae can be reused. and pumps and between swivels and cannulae. It is not designed for intravascular use. CO-EX™ is available in bulk, non-sterile 100 ft (30.5 m) rolls. Not autoclavable. Can be ETO sterilized. Specifications Tip OD 0.4 mm (0.016 in) Specifications Tip ID 0.2 mm (0.008 in) Compatible Swivel Inner Diameter Outer Diameter Color Material Polyurethane Inlet/Outlet 22 ga 0.61 mm (0.024 in) 1.60 mm (0.064 in) Clear Inlet/Outlet 25 ga 0.43 mm (0.017 in) 1.30 mm (0.051 in) Clear Order # Product ST1 72-9030 Micro-Cannula , Non-Sterile, pkg. of 1 Order # Product ST1 72-9031 Micro-Cannula, Non-Sterile, pkg. of 50 ST1 72-4426 CO-EX™ External Infusion Tubing, 22 ga ST1 72-6122 CO-EX™ External Infusion Tubing, 25 ga

Taxol is a registered trademark of Eli Lilly, Inc. CO-EX is a trademark of Solomon Scientific.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 123 CATHETERS

Solomon SoloCath™ Catheters

Heparin Active Anti-Thrombin Conformed Thrombin Thrombin- Sequence ™ Anti-Thrombin Anti-Thrombin Solomon SoloCath Catheters Complex

• Venous access • Arterial access • Blood collection circuits • Lymphatic access & SAMPLING DELIVERY CBAS® Heparin-Coated Polyurethane Catheters The Carmeda® BioActive Surface (CBAS®) is the product of Carmeda AB in Stockholm, Sweden.

Consider using CBAS® heparin-coated catheters for improved patency in studies lasting two weeks or longer, blood sampling applications, and when working with high-value animals. How CBAS® Works: CBAS® is a patented process from Carmeda® for applying heparin 1) CBAS® heparin “active sequence” is available to bind to the surfaces of biomaterials. The active sequence of the heparin with antithrombin. molecule serves to halt the clotting cascade. One of the most respected thromboresistant coatings available, CBAS® has been 2) Antithrombin conforms to accelerate binding with used in a number of human medical devices including coronary thrombin and other coagulation factors. stents, vascular grafts, oxygenator circuits and artificial hearts. 3) Coagulation effect of thrombin is neutralized by Foley, et. al. describes longer patency and fewer positive blood formation of thrombin-antithrombin complex. cultures from CBAS®-coated catheters in rats.1 While heparin itself is not antimicrobial, it does reduce the aggregation of blood proteins 4) Thrombin-antithrombin complex washes away. CBAS® on catheters, thereby minimizing the nutrients and binding sites for heparin “active sequence” remains intact and is many microorganisms. Appelgren, et. al. demonstrated a substantial available repeatedly to bind with antithrombin. reduction in infections from CBAS®-coated catheters in humans.2 Reduces Infections CBAS® has also shown benefits in ophthalmic, urinary, lymphatic Human clinical studies using CBAS® and other heparin coatings and intraperitoneal applications. For example, Zareie describes document a clear anti-infective benefit from heparin coatings. improved patency of intraperitoneal catheters coated with CBAS® While heparin is not an antimicrobial per se, it does remove the (80% catheter survival in rats at 5 weeks with CBAS® coated blood nidus for microorganisms thereby minimizing the nutrients catheters, versus 43% with uncoated silicone).3 and binding sites for many of the unfavorable blood proteins. Appelgren, et. al. demonstrated a 50% reduction in infections from Citations: CBAS® coated catheters in humans. Visit www.carmeda.com for 1. Foley P, et al. Effect of covalently bound heparin coating on patency and biocompatibility of long-term indwelling catheters in the rat jugular vein. Comparative Medicine. 52:243-8. additional information and complete CBAS® bibliography (200+ 2. Appelgren P, et al. Surface heparinization of central venous catheters reduces microbial references). colonization in vitro and in vivo: results from a prospective, randomized trial. Crit Care Med. 24(9):1482-9. 1996. 3. Zareie M, et al. Improvement of a chronic rat model for peritoneal dialysis by using heparin- Specifications coated catheters. Advances in Peritoneal Dialysis. 20:150-4. 2004. Duration Long-term; remains bioactive for several months 4. Jain, G et al. Does Heparin Coating Improve Patency or Reduce Infection of Tunneled Dialysis Stability Non-leaching; does not come off of catheter Catheters. Clin J AmSoc Nephrol. 4(11): 1787-1790. 2009. Systemic effect Non-leaching; coating is undetectable in blood Half-life Coating is not consumed; same heparin works repeatedly Reactivity Coating is non-reactive with almost all compounds Sterilization EtO only SoloCath is a trademark of Solomon Scientific. Currently available on polyurethane catheters Carmeda and CBAS are registered trademarks of Carmeda AB. Availability

124 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com CATHETERS

SoloCath™ Catheters (continued) Polyurethane Catheters

• Most thromboresistant material Clear, round distal tip, two movable suture bulbs and attachment • Rounded distal tip is less traumatic to intimal lining of sleeve. Individually packaged and sterilized. Sold in package of 5. blood vessels Order # Product We offer a full range of silicone, polyurethane and heparin coated ST1 72-6127 Polyurethane, 2 Fr, 60 cm, no Luer polyurethane catheters in sizes for all species. With over 25 years ST1 72-6128 Polyurethane, 3 Fr, 60 cm, no Luer of experience designing and manufacturing laboratory animal ST1 72-4410 Polyurethane, 3.5 Fr, 60 cm, no Luer catheters, we can help you choose the ideal catheter for your ST1 72-4411 Polyurethane, 5 Fr, 60 cm, no Luer application. ST1 72-4412 Polyurethane, 7 Fr, 60 cm, no Luer Biomaterials CBAS® Heparin Coated Polyurethane Catheters Silicone rubber continues to be the most popular catheter material; however, polyurethanes have been proven to be more Clear, round distal tip, two movable suture bulbs and attachment hemocompatible than silicone. The CBAS® heparin-coated sleeve. Individually packaged and sterilized. Sold in package of 5. polyurethane has proven to be the most thromboresistant of all available technologies. Order # Product Round Tips ST1 72-4403 CBAS® Heparin Coated Polyurethane, 3 Fr, 60 cm, no Luer ST1 72-4404 CBAS® Heparin Coated Polyurethane, 3.5 Fr, 60 cm, no Luer We recommend round tips for intravascular catheters as they are ST1 72-4405 CBAS® Heparin Coated Polyurethane, 5 Fr, 60 cm, no Luer less traumatic to the intimal lining of blood vessels. The sharp ST1 72-4406 CBAS® Heparin Coated Polyurethane, 7 Fr, 60 cm, no Luer edges on square-cut or bevel-cut catheters can irritate the vessel’s intimal lining and hasten the host’s thrombogenic response. Silicone Catheters All SoloCath™ catheters are supplied EtO sterilized. DELIVERY

Round distal tip, two movable suture bulbs, attachment sleeve & SAMPLING Specifications and depth markings (except 2 French). Individually packaged and Silicone 1.2 Fr 2 Fr 3 Fr 3.5 Fr 5 Fr 7 Fr sterilized. Sold in package of 5. OD (in) - 0.025 0.037 0.047 0.065 0.085 OD (mm) - 0.64 0.94 1.19 1.65 2.16 Order # Product ID (in) - 0.012 0.020 0.025 0.030 0.040 ST1 72-4413 Silicone, 2 Fr, 60 cm, no Luer, no depth markings, clear ID (mm) - 0.30 0.51 0.64 0.76 1.02 ST1 72-6129 Silicone, 3 Fr, 60 cm, no Luer, clear PU/CBAS® 1.2 Fr 2 Fr 3 Fr 3.5 Fr 5 Fr 7 Fr ST1 72-4416 Silicone, 3.5 Fr, 60 cm, female Luer, clear with stripe OD (in) 0.016 0.025 0.036 0.047 0.065 0.096 ST1 72-4417 Silicone, 5 Fr, 60 cm, female Luer, clear with stripe OD (mm) 0.41 0.64 0.91 1.19 1.65 2.43 ST1 72-4418 Silicone, 7 Fr, 60 cm, female Luer, clear with stripe ID (in) 0.009 0.013 0.023 0.027 0.040 0.052 ID (mm) 0.23 0.33 0.58 0.69 1.02 1.32

Applications (approximate for jugular vein, carotid artery, femoral artery/vein) 1.2 Fr* 2 Fr 3 Fr 3.5 Fr 5 Fr 7 Fr Mouse ✓ ✓ Rat < 100 g ✓ ✓ Rat 100-200 g ✓ Rat 200-300 g ✓ ✓ Rat 300-350 g ✓ ✓ Cat ✓ ✓ Rabbit ✓ ✓ ✓ Dog > 8 kg ✓ ✓ Mini-pig, Adult ✓ ✓ Pig, Adult ✓ Nonhuman Primate < 1 kg ✓ ✓ Nonhuman Primate 1-2 kg ✓ Nonhuman Primate 3-5 kg ✓ ✓ Nonhuman Primate >5 kg ✓ ✓ *Note: 1.2 Fr is distal end of PU FunnelCath™.

SoloCath™ is a trademark of Solomon Scientific. FunnelCath™ is a trademark of Genesis Medical Interventional, Inc.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 125 CONNECTORS

Instech Luer Stubs (Blunt Needles) Order # Product ST1 72-4467 Luer stub, 14 ga (olive) x 12 mm (0.5 in), Use these female Luer stubs to connect infusion tubing or catheters non-sterile, pkg. of 100 to syringes or other male Luer connectors. They are available ST1 72-2845 NEW Luer stub, 15 ga (amber) x 12 mm (0.5 in),

& SAMPLING non-sterile in quantities of 100. They may also be ordered as part non-sterile, pkg. of 100 DELIVERY of Instech's pre-assembled, sterile infusion kits or individually ST1 72-4468 Luer stub, 16 ga (violet) x 12 mm (0.5 in), packaged and sterilized. Other sizes may be available on request. non-sterile, pkg. of 100 Not for human use. ST1 72-2846 NEW Luer stub, 17 ga (white) x 12 mm (0.5 in), non-sterile, pkg. of 100

ST1 72-6126 Luer stub, 18 ga (green) x 12 mm (0.5 in), non-sterile, pkg. of 100 ST1 72-6136 Luer stub, 20 ga (pink) x 12 mm (0.5 in), non-sterile, pkg. of 100 ST1 72-4470 Luer stub, 21 ga (purple) x 12 mm (0.5 in), non-sterile, pkg. of 100 ST1 72-4439 Luer stub, 22 ga (blue) x 12 mm (0.5 in), non-sterile, pkg. of 100 ST1 72-4471 Luer stub, 22 ga (blue) x 6 mm 0.25 in, non-sterile, pkg. of 100 ST1 72-4472 Luer stub, 23 ga (orange) x 12 mm (0.5 in), non-sterile, pkg. of 100 ST1 72-6125 Luer stub, 25 ga (red) x 12 mm (0.5 in), non-sterile, pkg. of 100 ST1 72-2847 NEW Luer stub, 27 ga (gray) x 12 mm (0.5 in), non-sterile, pkg. of 100

Instech Y Connector (3-Way Connector)

These new Y connectors are available in two sizes; 22 gauge and 25 gauge. They feature three stainless steel tubes and a hub made of Kel-F® (PCTFE, chemically resistant). The tubes extend approximately 6mm from the hub. The dead volume of the 22 gauge version from one channel to the next is less than 3 µl. Individually packaged and sterilized.

Order # Product ST1 75-0066 Y Connector, 22 ga, sterile, pkg. of 1 ST1 75-0067 Y Connector, 25 ga, sterile, pkg. of 1

Kel-F is a registered trademark of 3M.

126 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com TUBING & CONNECTORS

Stainless Steel Tubing Connectors

Solomon Polyurethane Intravascular Tubing Instech Stainless Steel Tubing Connectors

This clear tubing is provided non-sterile and can be ETO sterilized. These tubing couplers are used to connect catheters to external

infusion tubing. The plugs can be used to seal off an externalized Specifications catheter before an infusion experiment begins. The couplers and Size 2 Fr 2 Fr stiff 3 Fr 3 Fr stiff 3.5 Fr 5 Fr 7 Fr plugs are supplied non-sterile in packages of 100. OD (in) 0.026 0.026 0.038 0.038 0.047 0.066 0.096 Order # Length Tubing OD ID OD (mm) 0.66 0.66 0.97 0.97 1.20 1.68 2.44 DELIVERY & SAMPLING ID (in) 0.013 0.013 0.024 0.024 0.027 0.040 0.052 Coupler ID (mm) 0.33 0.33 0.61 0.61 0.69 1.02 1.32 ST1 75-0051 8 mm 27 ga 0.41 mm 0.21 mm (0.3 in) (0.016 in) (0.0083 in) ST1 72-6124 10 mm 25 ga 0.51 mm 0.25 mm Order # Product (0.4 in) (0.020 in) (0.010 in) ST1 72-6130 Polyurethane Intravascular Tubing, 2 Fr, 9 x 12 ft (3.65 m) ST1 72-4434 8 mm 23 ga 0.64 mm 0.33 mm lengths, 33 m (108 ft) per bag, clear (0.3 in) (0.025 in) (0.013 in) ST1 72-4429 Polyurethane Intravascular Tubing, 3 Fr, 9 x 12 ft (3.65 m) ST1 75-0052 8 mm 22 ga 0.71 mm 0.41 mm lengths, 33 m (108 ft) per bag, clear (0.3 in) (0.028 in) (0.016 in) ST1 72-4431 Polyurethane Intravascular Tubing, 3.5 Fr, 9 x 12 ft (3.65 m) ST1 72-4437 15 mm 22 ga 0.71 mm 0.41 mm lengths, 33 m (108 ft) per bag, clear (0.6 in) (0.028 in) (0.016 in) ST1 72-4432 Polyurethane Intravascular Tubing, 5 Fr, 50 x 24 in (60 cm) ST1 72-6123 15 mm 20 ga 0.91 mm 0.61 mm lengths, 30.5 m (100 ft) per bag, clear (0.6 in) (0.036 in) (0.024 in) ST1 72-4433 Polyurethane Intravascular Tubing, 7 Fr, 50 x 24 in (60 cm) ST1 75-0053 15 mm 17 ga 1.47 mm 1.07 mm lengths, 30.5 m (100 ft) per bag, clear (0.6 in) (0.058 in) (0.042 in) Plug ST1 75-0054 12 mm 25 ga 0.51 mm NA (0.5 in) (0.020 in) ST1 72-4436 12 mm 23 ga 0.64 mm NA (0.5 in) (0.025 in) ST1 72-4438 12 mm 22 ga 0.71 mm NA (0.5 in) (0.028 in) ST1 72-6132 12 mm 20 ga 0.91 mm NA (0.5 in) (0.036 in)

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 127 INFUSION SETS & CATHETER INTRODUCER

Standard Butterfly Infusion Set These Butterfly Catheters make veni-puncture easier with automatic alignment of the needle in bevel up position, eliminating needle roll during insertion. After venipuncture the wings spread flat to provide a firm anchor for taping. Since there is no bulky needle hub to tape down, there is less chance for pressure irritation to develop. The short needle shaft, ultra-flexible tubing, and firm anchorage minimize the possibility of needle movement within the vein. The needle has thin walls and is double bevel ground. The open end needle guard permits priming with the guard in place so the needle can remain covered until the moment of use. A transparent cap covering the adapter keeps it sterile after the package is opened. Harvard Apparatus offers three different Butterfly Catheter Infusion Sets. For easy recognition the adapter is color coded according to the gauge size. Supplied in quantities noted.

Butterfly Catheter Infusion Sets Tubing Needle Tubing Tubing Quantity Set Type Gauge Length Length Volume Supplied Small Animal Butterfly Sets & SAMPLING

DELIVERY ST1 72-5966 25 19.1 mm 30.5 cm 0.44 ml 50 Butterfly Catheter Infusion Sets 3 ( ⁄4 in) (12 in) ST1 72-5965 25 12.7 mm 20.3 cm 0.29 ml 100 • Firm needle control for better positioning 1 ( ⁄2 in) (8 in) • Small Animal Butterfly sets have the smallest 27 12.7 mm 20.3 cm 0.29 ml 100

ST1 72-5967 1 butterfly needle, with outside diameters ranging ( ⁄2 in) (8 in) from 25 to 27 gauge Standard Butterfly Sets • Standard Butterfly sets are available with three ST1 72-5960 19 19.1 mm 30.5 cm 0.46 ml 50 3 different needle diameters and have a 30.5 cm (12 in) ( ⁄4 in) (12 in) length of tubing ST1 72-5963 21 19.1 mm 30.5 cm 0.45 ml 50 3 ( ⁄4 in) (12 in) • Intermittent Butterfly sets are for intermittent procedures. ST1 72-5964 23 19.1 mm 30.5 cm 0.45 ml 50 The adapter terminates in a resealing injection site which 3 ( ⁄4 in) (12 in) allows injection or blood sampling Intermittent Butterfly Sets These Butterfly Infusion Sets consist of a stainless steel needle with ST1 72-5962 21 19.1 mm 8.9 cm 0.19 ml 100 3 1 ( ⁄4 in) (3 ⁄2 in) butterfly wings, a length of tubing and an adapter. This adapter fits any standard IV, blood set or syringe and contains a flange to accept secure lock.

Vein Pick Catheter Introducer ST1 72-4169 Vein Pick Catheter Introducer • Makes catheter introduction simple and easy • For use with the “cut-down catheter” procedure

This simple Introducer will aid researchers with the introduction of catheters into small vessels. The tapered tip of the introducer is inserted into an incision in a vessel. The catheter then easily slides into the vessel by placing the catheter tip in the grooved underside of the Introducer. The Introducer is then removed allowing the catheter to be advanced to the desired position. Supplied sterile in a package of 50.

Order # Product ST1 72-4169 Vein Pick Catheter Introducer, pkg. of 50

References: 1. Disposable Guide for Introducing Catheters into Small Vessels from AMERICAN HEART Vein Pick Catheter JOURNAL, Vol. 73 No. 5, Pages 716-717, Harvey L. Chernoff, M.D., Marshal B. Kreidberg, M.D. Introducer entering a vein

128 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com JACKETS

Pillow Collar ST1 62-0058 Rat, Hamster & Mouse Rat Jacket Jackets

• Hook and loop fasteners for simple easy closure • Sizes available for rats, hamsters, and mice

ST1 62-0065 Mouse Jacket Manufactured with Lycra®/ spandex, these jackets are suitable for a wide range of continuous intravenous infusion applications. The Mouse Jackets have a double layer of Lycra®/spandex for additional durability. The jackets close by means of a hook and loop fastener and supplemental hooks provide additional security and better fit. Standard inserts are included for the rat (1.5 L x 0.75 W inch), the mouse (2.0 L x 1.0 W inch) and the hamster jackets. Dermal inserts can be purchased separately for both the rat and mouse jackets. These inserts are for studies where test articles Pillow Collars are dermally applied. They are a non-occlusive covering for the application site that helps prevent oral ingestion while allowing in-line

• Combine with an infusion jacket to protect surgical sites investigations to be carried out with ease. and equipment • To protect the animal in a post surgical or Order # Product treatment situation ST1 62-0064 Mouse Jacket, Small, Up to 25 g

ST1 62-0065 Mouse Jacket, Medium, 25 to 30 g DELIVERY

• Collars available for dogs and rabbits & SAMPLING ST1 62-0066 Mouse Jacket, Large, 30+ g These Pillow Collars are designed for a wide range of applications ST1 62-0056 Rat Jacket, X-Small, 100 to 150 g in both dogs and rabbits. These collars are available in either black ST1 62-0057 Rat Jacket, Small, 150 to 250 g or white. The dog collars range in size from small to extra large ST1 62-0058 Rat Jacket, Medium, 250 to 350 g and are 3 inches thick. The rabbit collars are available in small and ST1 62-0059 Rat Jacket, Large, 350 to 500 g medium sizes and are 1.5 inches thick. All collars are fully washable. ST1 62-0060 Rat Jacket, X-Large, 500+ g ST1 62-0061 Hamster Jacket, Small, Up to 100 g Weight Interior x Exterior ST1 62-0062 Hamster Jacket, Medium, 100 to 175 g White Black Size Range Diameter ST1 62-0063 Hamster Jacket, Large, 175+ g Pillow Collars for Dogs ST1 62-0067 Rat Jacket Insert for Dermal Studies ST1 72-4004 ST1 72-4008 Sm. 5 to 7 kg 8.26 x 20.3 cm (3.25 x 8 in) ST1 62-0068 Mouse Jacket Insert for Dermal Studies ST1 72-4005 ST1 72-4009 Med. 8 to 12 kg 10.2 x 20.3 cm (4 x 8 in) ST1 72-4006 ST1 72-4010 Lg. 13 to 18 kg 12.7 x 24.1 cm (5 x 9.5 in) ST1 72-4007 ST1 72-4011 X-Lg. 18 to 25 kg 14 x 32.4 cm (5.5 x 12.75 in) Guinea-Pig Jackets Pillow Collars for Rabbits • Hook and loop ST1 72-4012 ST1 72-4014 Sm. up to 3.5 kg 6.4 x 14 cm (2.5 x 5.5 in) fasteners for simple ST1 72-4013 ST1 72-4015 Med. over 3.5 kg 6.4 x 19.1 cm (2.5 x 7.5 in) easy closure • Edges and leg openings Ferret Jackets bound with cotton ST1 62-0070 Guinea Pig Jacket jersey for maximum 3 • ⁄4-length design for long lean body shape comfort • Hook and loop fasteners for simple easy closure For use in intravenous infusion and other applications or to These Jackets are made of double layer nylon canvas, with edges accommodate portable equipment, these jackets are made of nylon and leg openings bound by cotton jersey for comfort. Hook and canvas. The edges and leg openings are bound with cotton jersey loop fasteners adjust garment to the size of the animal, helping to for comfort. Hook and loop fasteners permit easy adjustment to fit compensate for any change in seasonal body weight. Available in the animal’s size. Five hooks provide added security. Available in three sizes. three sizes.

Order # Product Order # Product ST1 62-0072 Ferret Jacket, Small, Up to 750 g ST1 62-0069 Guinea-Pig Jacket, Small, Up to 350 g ST1 62-0073 Ferret Jacket, Medium, 750 to 1000 g ST1 62-0070 Guinea-Pig Jacket, Medium, 350 to 600 g ST1 62-0074 Ferret Jacket, Large, 1000+ g ST1 62-0071 Guinea-Pig Jacket, Large, 600+ g

Lycra® is a registered trademark of Ivista.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 129 JACKETS

ST1 62-0089 Dog Jacket ST1 62-0086 Cat Jacket with Optional Zipper Pocket

Large Animal Jackets Order # Product ST1 62-0088 Dog Jacket Full Length with Rear Leg Enclosures, X-Small, • Double-layered 100% polyester mesh for air circulation 2.5 to 5 kg • Double stitched for superior strength ST1 62-0089 Dog Jacket Full Length with Rear Leg Enclosures, Small, 5 to 7 kg

& SAMPLING • Leg openings bound with cotton jersey for added comfort

DELIVERY ST1 62-0090 Dog Jacket Full Length with Rear Leg Enclosures, Medium, • Back panel made from Lycra®/spandex for better fit and 8 to 12 kg animal comfort ST1 62-0091 Dog Jacket Full Length with Rear Leg Enclosures, Large, 13 to 18 kg This wide range of jackets offers biomedical researchers the most ST1 62-0092 Dog Jacket Full Length with Rear Leg Enclosures, X-Large, advanced jackets using the latest manufacturing techniques and 18 to 25 kg 3 materials. They are fastened by two zippers attached to a Lycra®/ ST1 62-0093 Dog Jacket ⁄4 Length, X-Small, 2.5 to 5 kg

3 spandex expansion panel which provides better fit and comfort. ST1 62-0094 Dog Jacket ⁄4 Length, Small, 5 to 7 kg

3 Equipment pockets are available separately, and must be ordered ST1 62-0095 Dog Jacket ⁄4 Length, Medium, 8 to 12 kg with the jacket. See page 131 for complete details. 3 ST1 62-0096 Dog Jacket ⁄4 Length, Large, 13 to 18 kg

3 Dog Jacket ⁄4 Length, X-Large, 18 to 25 kg Dog Jackets ST1 62-0097 ST1 62-0085 Cat Jacket, Full Length, Small, Up to 2.5 kg Designed primarily for beagles and hound-type dogs. Hook and ST1 62-0086 Cat Jacket, Full Length, Medium, 2.5 to 4.5 kg loop fasteners at the neck and/or base of the jacket provide added ST1 62-0087 Cat Jacket, Full Length, Large, 4.5+ kg 3 security and adjustment. They are available in ⁄4 or full length with ST1 62-0075 Rabbit Jacket Full Length with Rear Leg Enclosures, X-Small, rear leg enclosures. Up to 2.7 kg ST1 62-0076 Rabbit Jacket Full Length with Rear Leg Enclosures, Small, Cat Jackets 2.7 to 3.6 kg These jackets are designed for comfort and fit in three sizes to fit ST1 62-0077 Rabbit Jacket Full Length with Rear Leg Enclosures, Medium, 3.6 to 4.5 kg your size feline. All are full length with rear leg enclosures. ST1 62-0078 Rabbit Jacket Full Length with Rear Leg Enclosures, Large, 4.5 to 5.4 kg Rabbit Jackets ST1 62-0079 Rabbit Jacket Full Length with Rear Leg Enclosures, X-Large, Designed to be used with the New Zealand White rabbit. They 5.4+ kg 3 3 are available ⁄4 length or full length with rear leg enclosures. Not ST1 62-0080 Rabbit Jacket ⁄4 Length, X-Small, Up to 2.7 kg 3 pictured. ST1 62-0081 Rabbit Jacket ⁄4 Length, Small, 2.7 to 3.6 kg 3 ST1 62-0082 Rabbit Jacket ⁄4 Length, Medium, 3.6 to 4.5 kg

3 Swine Jackets ST1 62-0083 Rabbit Jacket ⁄4 Length, Large, 4.5 to 5.4 kg

3 Swine Jackets are available by special order. Breeds available ST1 62-0084 Rabbit Jacket ⁄4 Length, X-Large, 5.4+ kg include micro, mini, Yucatan, as well as specific farm or market ST1 62-0105 Jacket Pocket, 3 x 7 x 2 in swine from juvenile through market weight. All jackets feature ST1 62-0106 Jacket Pocket, 7 x 5.5 x 1.5 in, with 11 in Zipper expandable panels made of Lycra®/spandex which permits growth ST1 62-0107 Jacket Pocket, 6 x 4 x 2 in, with 7 in Zipper of the abdominal area and ensures both comfort and fit. Please call ST1 62-0108 Jacket Pocket, 5.25 x 3.5 x 1.5 in, with 9 in Zipper for additional information.

Custom Jackets Custom Jackets to fit other species are available on an individual basis. Prices are based on the complexity and quantity of the order. Please call for additional information.

Lycra is a registered trademark of Ivista.

130 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com JACKETS

ST1 62-0099 Small Rhesus Primate Jacket

DELIVERY & SAMPLING

Rhesus Primate Jackets Jacket Pockets for Large Animal & Primate Jackets • Seven sizes for Rhesus primates • Light padding at the neck opening and waist for comfort Four standard pockets are offered as an accessory to our large animal and primate jackets. They must be ordered at the same time • Hook and loop closures ensure proper fit as the jacket. Custom size pockets are available by special order. These jackets are double-layered, 100% polyester mesh which permits air circulation. The expandable back panel has two zippers Order # Product that secure the jacket. All the zippers can be secured by a clip to ST1 62-0105 Jacket Pocket, 3 x 7 x 2 in help prevent the animal from tampering with the jacket. These ST1 62-0106 Jacket Pocket, 7 x 5.5 x 1.5 in, with 11 in Zipper jackets are double stitched for durability. Other primate jackets are ST1 62-0107 Jacket Pocket, 6 x 4 x 2 in, with 7 in Zipper available by special order. Please call for additional information. ST1 62-0108 Jacket Pocket, 5.25 x 3.5 x 1.5 in, with 9 in Zipper

Order # Product ST1 62-0098 Rhesus Primate Jacket, X-Small, up to 2 kg ST1 62-0099 Rhesus Primate Jacket, Small, 2 to 3 kg ST1 62-0100 Rhesus Primate Jacket, Medium, 3 to 5.5 kg ST1 62-0101 Rhesus Primate Jacket, Large, 5.5 to 7 kg ST1 62-0102 Rhesus Primate Jacket, X-Large, 7 to 8 kg ST1 62-0103 Rhesus Primate Jacket, XX-Large, 8 to 10 kg ST1 62-0104 Rhesus Primate Jacket, XXX-Large, 10+ kg

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 131 SLING SUITS & FRAMES

ST1 72-0050 Sling Suit with ST1 72-0048 Frame & SAMPLING DELIVERY Rodent Sling Suit & Frame Large Animal Sling Suits and Frames

• Rugged sling suits withstand repeated laundering for Similar to the Rodent Sling Suits, the Large Animal Sling Suits are long life manufactured from a polyester mesh fabric sewn in double layers.

• Large animal frames constructed of stainless steel for The jacket portion of the suit is closed with two zippers attached superior quality and easy cleaning to an expandable spandex insert allowing for an adjustable fit. All jackets are unisex and all edges and leg openings are bound • Large animal sling suits available for rabbits, with cotton jersey fabric for added comfort. The suit attaches to cats and dogs the frame with detachable zippered sleeves along the length of the jacket. This enables the animal to be removed from the frame The Sling Suit is manufactured from two fabrics for durability. without removing the jacket. The bars of the frame slip through The underside of the suit is made from a polyester mesh fabric these detachable sleeves. The frames are constructed from square which allows air to circulate while the animal is being restrained. stainless steel tube, which is mounted onto a UPVC base for The upper portion of the suit is made from a nylon-coated canvas superior quality and easy cleaning. The sling suits and frames are with hook and loop fasteners for a custom fit. The Rodent Sling sold separately. Frame is manufactured with a durable high impact plastic base and adjustable connectors and supports made of stainless steel for dependability and easy cleaning. The sling suits and frames are sold Large Animal Sling Suits and Frames separately. Size Order # Cat Weight Order # Dog Weight X-Small – – ST1 72-0049 2.5 to 5 kg Rodent Sling Suits and Frames Small ST1 72-0044 Up to 2.5 kg ST1 72-0050 5 to 7 kg Size Order # Rat Weight Order # Rabbit Weight Medium ST1 72-0045 2.5 to 4.5 kg ST1 72-0051 8 to 12 kg X-Small ST1 72-0032 100 to 150 g ST1 72-0038 up to 2.7 kg Large ST1 72-0046 4.5+ kg ST1 72-0052 13 to 18 kg Small ST1 72-0033 150 to 250 g ST1 72-0039 2.7 to 3.6 kg X-Large – – ST1 72-0053 18 to 25 kg Medium ST1 72-0034 250 to 350 g ST1 72-0040 3.6 to 4.5 kg Frame ST1 72-0043 – ST1 72-0048 – Large ST1 72-0035 350 to 500 g ST1 72-0041 4.5 to 5.4 kg X-Large ST1 72-0036 500+ g ST1 72-0042 5.4+ kg Frame ST1 72-0031 – ST1 72-0037 –

132 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com RESTRAINT UNIT

Restraint Frame Restraint Sling

Large Animal Restraint Unit Two sizes of restraint frames are available. The large restraint frame for dogs measures, H x W x D, 99 x 61 x 91.4 cm (39 x 24 x 36 inch). • The ideal way to immobilize large animals The extra-large restraint frame for swine/sheep is slightly longer

• The rugged hammock provides stable, immobile support measuring, H x W x D, 99 x 61 x 121.9 cm (39 x 24 x 48 inch). Both with comfort frames are mounted on four heavy duty caster for mobility. Two • Frame is constructed from durable 2.5 cm2 (1 inch2) have foot-activated brakes. stainless steel rods for exceptional quality & long life

Order # Product DELIVERY

• Available for dogs and swine/sheep & SAMPLING ST1 72-0054 Complete Dog Restraint Unit, Includes Large Frame and Dog This restraint units include two parts: the rugged sling hammock Sling Hammock* and the heavy duty restraint frame. The sling hammock is made ST1 72-4033* Complete Swine/Sheep Restraint Unit: Includes X-Large from washable canvas type material that can withstand repeated Frame and Swine/Sheep Sling Hammock* washing. All leg and waste openings are edged with cotton jersey ST1 72-0055 Dog Sling Hammock Only* material for comfort. Nylon webbing is added to key points where ST1 72-0058 Swine/Sheep Sling Hammock Only* extra strength is required. Heavy brass grommets allow the use of * Must specify sex of the animal. neck restraints to minimize the animal’s head movement. Two sizes are available for use with dogs and swine/sheep. The restraint frame is manufactured with durable 1 inch square stainless steel rods which provides exceptional strength while being light weight. Each corner has self-locking, quick release cleats for limb ropes. These cleats help to prevent entanglement or accidental release. A deep “V” opening permits unimpeded access to the head of the animal. The hammock slides onto the two upper horizontal rods. Once attached to the rods, simply load the animal into the hammock and lift the entire unit onto the frame. The frame has a deep opening on one side to minimize lifting of the animal.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 133 METABOLIC CAGES

ST1 52-6707 Metabolic Cage for Large Rodents 1. Cover: with ST1 52-6756 Stand (not included) Large, vented cover keeps animal securely contained. Removable for easy access.

2. Upper Chamber: 1 7 Made of transparent polycarbonate. Surface is smooth, gnaw-proof and noiseless. Easily cleaned with warm soapy water.

3. Feeder Chamber: 2 Located outside cage. Size discourages rodent from nesting or sleeping inside. 3 8 4. Feeder Drawer: Polycarbonate drawer slides out for easy filling without disturbing 4 the animal. Ideal for slurries, liquids or powders. Not designed for food in pellet form. Rear portion helps to catch spilled food to prevent contamination of feces.

5. Collection Funnel and Separating Cone: 9

& SAMPLING Unique design and non-wetting polymethylpentene ensure

DELIVERY 5 immediate and complete separation of feces and urine.

6. Feces Collection Tube: 6

Non-wetting polymethylpentene. Pellets roll down the sides of the funnel and are collected in the tube. Unlocks from outside the cage, 10 with a single twist, without disturbing the animal.

7. Water Bottle:

11 Polycarbonate, calibrated, with stainless steel cap and sipper tube; 100 ml bottle for Metabolic Cages for Small Rodents; 250 ml bottle for Metabolic Cage for Large Rodents.

Metabolic Cages for Rodents 8. Water Bottle Support & Spillage Collection Tube: Designed to prevent water from entering the cage and • Provide uncontaminated, reliable samples for accurate contaminating the urine. Calibrated spill tube facilitates metabolic monitoring measurement of the actual water intake. • Unique funnel-and-cone design completely and immediately separates feces and urine into tubes outside 9. Lower Chamber: the cage Polycarbonate; can be removed without disturbing the animal; • Available in four sizes to accommodate­ mice, rats and easily cleaned. other rodents of various weights • Autoclavable 10. Urine Collection Tube:

These metabolic cages prevent urine from washing over and Non-wetting polymethylpentene. Urine flows along the inside of entering the feces tube. Each excreta tube can be removed the collection funnel and is directed by the urine ring into the urine without disturbing the animal. Food and water systems allow the tube. Graduated in cubic centimeters. Unlocks from outside the animal’s intake to be easily measured and are located outside the cage without disturbing the animal. cage to prevent spillage from contaminating the excreta. All cage components are autoclavable. 11. Stand: Both the Small Rodent and Large Rodent Metabolic Cages require A stand or rack must be used with each Rodent Metabolic Cage. The the ST1 52-6756 Single Cage Stand. ST1 52-6756 stainless steel Single Cage Stand (pictured) supports one cage and provides easy access to all parts. Multiple cage racks are also available, see page 138.

134 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com METABOLIC CAGES

Metabolic Cage for Large Rodents Metabolic and Diuresis Cages for Small Rodents • For rodents weighing from 300 to 850 grams • For rodents less than 300 grams This cage is for rats, guinea pigs, and hamsters weighing from 300 to 850 grams. It includes the same fluid collection tubes and rings All of the Rodent Metabolic cages are identical in size but are as the Metabolic Cages for Small Rodents. In addition, the upper supplied with different components for different sized rodents. chamber, water bottle and support, feeder assembly and urine collection tube are sized for large rodents. These metabolic cages include four fluid collection tubes with funnels (two water spillage tubes and two urine collection tubes), The Large Rodent Metabolic Cage is extremely versatile. It can two feces collection tubes, two urine rings and a feeder chamber be adapted to house smaller rodents by adding the ST1 52-6819 and drawer sized for the animal specified. The cage for mice also Adapter Gate, see below, plus either the ST1 52-6815 Mouse Kit, has mouse-size support grid and urine collection tubes. These ST1 52-6817 Feeder Assembly for Rats under 150 g or ST1 52-6818 metabolic cages are ideal for groups of three or more rats or mice. Feeder Assembly for Rats 150 to 300 g, see below. The Diuresis Cage for Mice is identical in size to the Metabolic Cages This cage is ideal for groups of three or more rodents. Cages and but has a smaller separating cone and collection funnel to minimize racks must be purchased separately. evaporation. It is used to collect by-products from a single mouse. Cages and Racks must be purchased separately. Specifications

1 Dimensions, H x W x D 52 x 28 x 36 cm (20 ⁄ 2 x 11 x 14 in)

1 Specifications Domicile Portion, 24 x 18 cm (9 ⁄ 2 x 7 in) ID x H Dimensions, H x W x D 48 x 28 x 36 cm (19 x 11 x 14 in) 1 Area 450 cm2 (70 in2) Domicile Portion, 20 x 14 cm (8 x 5 ⁄ 2 in) ID x H Area 320 cm2 (50 in2) Order # Product

ST1 52-6707 Metabolic Cage for Large Rodents DELIVERY

Order # Product & SAMPLING ST1 52-6756 Single Cage Stand ST1 52-6731 Metabolic Cage for Mice ST1 52-6764 Multiple Cage Rack, Vertical ST1 52-6723 Metabolic Cage for Rats < 150 g ST1 52-6715 Metabolic Cage for Rats 150 to 300 g ST1 60-1931 Diuresis Cage for Mice

1 1 Replacement Feeder Chamber and Drawer ST1 52-6756 Single Cage Stand, measures 34 x 31 x 31 cm (13 ⁄4 x 12 ⁄2 x 1 12 ⁄2 in), (Fits all of the Small Rodent Cages listed above - These assemblies include a polycarbonate feeder drawer and See picture on facing page) stainless steel feeder chamber. All three sizes fit the Metabolic ST1 52-6764 Multiple Cage Rack, Vertical Cages for Small Rodents. For use with the ST1 52-6707 Large ST1 72-9060 Collectio Tube Chiller Rodent Metabolic Cage, it is necessary to add the ST1 52-6819 Adapter Gate, see below.

Order# Product ST1 52-6816 For Mice: 2.4 cm (1 in) feeder opening

3 ST1 52-6817 For Rats: < 150 g, 3.5 cm (1 ⁄8 in) feeder opening ST1 52-6818 For Rats: 150 to 300 g, 5 cm (2 in) feeder opening ST1 52-6815 Mouse Kit. Includes ST1 52-6816 Mouse Feeder Assembly, mouse-sized grid and two mouse-sized urine tubes. Converts ST1 52-6723 Metabolic Cage for Rats < 150 g and ST1 52-6715 Metabolic Cage for Rats 150 to 300 g to a Metabolic Cage for Mice ST1 52-6819 Replacement Adapter Gate. Allows smaller rodents to be housed in the ST1 52-6707 Metabolic Cage for Large Rodents; the Adapter Gate is a standard part of that cage and is available separately here; when the gate is placed in the opening for the cage’s feeder chamber or water bottle, a smaller feeder or water bottle support can be substituted; stainless steel ST1 52-6820 Replacement Angle Adapter. Replacement part for the water bottle supplied with ST1 52-6707 Metabolic Cage for Large Rodents; autoclavable; transparent ST1 60-1932 Diuresis Cage Adapter Kit for Mice. Converts any metabolic cage for rodents into a diuresis cage for mice; includes funnel, short lower chamber and stainless steel screen

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 135 METABOLIC CAGES

This metabolic cage designed specifically for mice feature a unique Mouse Metabolic Chamber funnel and cone design that effectively separates feces and urine into tubes outside the cage. The way the cage is designed allows for complete and total separation of urine and feces, the separation is immediate and complete. The usable floor area is 200 cm2 with an internal height of 130 mm. The cage has a two part feeding chamber located outside of the cage itself, the front chamber catches spilled food so there is no possibility of food/waste contamination. The water bottle has a special drain to collect overflow while the animal is drinking and diverts it into a separate collection tube separate from the waste collection tubes. The feeding drawers slide out easily, allowing for removal without interrupting the study. This cage is ideal for individual mice. The ST1 72-9061 Mouse Metabolic Cage comes complete with the following components: 1. The cone 2. The separation cone

& SAMPLING 3. The urine collection ring DELIVERY 4. Two collection tubes (for feces and urine). 5. The upper chamber with lid 6. The lower chamber with closure

7. Water bottle 8. Tube for water spillage Components #1 to 4 are made of Polymethylpentene (PMP) while components #5 to 8 are made of Polycarbonate. Mouse Metabolic Chamber The cage can be used without a cage stand, but it is recommended • Designed to house individual mice that one be used. Use of a stand facilitates easy access to all of • 200 cm2 usable floor space the collection tubes without having to physically lift the cage and disturb the animal. If you choose to use the cage stand or a • Accurate and reliable separation of solid and liquid waste multiple cage rack, it is necessary to also purchase the ST1 72-9062 • Special drain at drinking station separates spilled drink support plate. from liquid waste • Autoclavable Order # Product ST1 72-9061 Single Mouse Metabolic Cage ST1 52-6756 Single Mouse Metabolic Cage Stand* ST1 52-6764 Multiple Cage Rack, Vertical* ST1 72-9062 Support Plate for Cage and Stand ST1 72-9059 Urine Collection Tube, 15 ml for Mice ST1 72-9058 Urine Collection Tube, 70 ml for Rats and Diabetic Mice

* Note: Requires ST1 72-9062 support plate.

136 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com METABOLIC CAGES

Mouse Metabolic Chamber Mouse Metabolic Chamber

• Designed specifically to house individual mice • Conforms to code for isolator units • Constructed from high impact resistant acrylic • The lid holds disposable air filter pad • All connections are sealed with o-rings • Urine vessel is removable and disposable

The Metabolic Chamber for Mice is designed to house individual mice for 24 hour periods or longer for the purpose of studying the animal’s metabolic function or effects of intervention on the animal’s metabolism. These include, but are not limited to, daily food and water intake, effects of different drug therapies, urinary protein excretion and renal function studies. This chamber is specifically designed to accurately separate urine from feces for analysis. The chamber is an isolator unit that conforms to the housing specifications in the Guide for the Care and Use of DELIVERY & SAMPLING Laboratory Animals. The chamber is constructed of gas sterilizable acrylic and all connections are sealed with o-rings. The lid holds a disposable air Optional Swivel filter pad. The urine/feces separation cone is stainless steel, as are casters the floor and filter screens. The urine collection vessel is removable Mouse Metabolic and disposable. The chamber is therefore suitable for use in barrier Chamber Rack facilities. These chambers are actively used in research projects which have been reported in presentations at national scientific • Holds up to 15 Metabolic meetings. The chambers have proven to be particularly useful Chambers for mice for research involving transgenic mice which must be housed individually for phenotyping and metabolic studies. • Easy assembly • All aluminum construction Order # Product • Non-skid leveling adjusters ST1 72-7060 Metabolic Chamber for Mice • Durable baked powder epoxy finish Metabolic Chamber Includes: • Zinc plated assembly hardware ST1 72-7061 Stainless Steel Funnel Assembly • Optional stainless steel hardware ST1 72-7062 Stainless Steel Screen Floor ST1 72-7063 Assembly Cage Lid • Optional swivel casters with swivel locks and wheel brakes ST1 72-7064 Acrylic Food Holder Assembly ST1 72-7065 Acrylic Water Bottle Assembly • Chilled unit available ST1 72-7066 Urine Collection Vessel The Metabolic Chamber Rack is designed to hold up to 15 Replacement Parts: individual Metabolic Chambers for Mice (ST1 72-7060). The ST1 72-7067 Replacement Water Bottle for Mouse Metabolic Chamber unique design allows easy insertion and removal of the cages by ST1 72-7068 Replacement O-Ring Set for Mouse Metabolic Chamber placing each chamber through a large diameter hole in the rack

References: shelf. The base of the chamber is supported by a solid shelf. The 1. Flemming ER, Athirakul K, Oliverio MI, Key M, Goulet J, Koller BH, Coffman TM. Urinary solid base support shelf incorporates a safety plate with large concentrating function in mice lacking EP3 receptors for prostaglandin E2. diameter openings to also accept the chamber base. This design Am J Physiol 1998; 275:F955-61. feature provides stability for the chambers with out requiring 2. Oliverio MI, Delnomdedieu M, Best CF, Li P, Morris M, Callahan MF, Johnson GA, Smithies O, any complicated holding devices or clamping mechanisms. The Coffman TM. Abnormal water metabolism in mice lacking the type 1A receptor for angiotensin II. Am J Physiol (Renal Physiology) 2000; 278:F75-82. chambers are simply inserted or removed from the rack as easily 3. Oliverio MI, Best CF, Smithies O, Coffman TM. Regulation of sodium balance and blood pressure as placing a peg in a hole. Assembly is required. by the AT1A receptor for angiotensin II. Hypertension 2000; 35:550-4. 4. Pace AJ, Lee E, Athirakul K, Coffman TM, O’Brien DA, Koller BH. Failure of spermatogenesis in Order # Product mouse lines deficient in the Na+-K+-2Cl- cotransporter. J Clin Invest 2000; 105:441-50. ST1 72-7071 Metabolic Chamber Rack (without casters) 5. Athirakul K, Kim H-S, Audoly LP, Smithies O, Coffman TM. Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition. In Press, Kidney Int. ST1 72-7072 Metabolic Chamber Rack (with swivel casters)

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 137 MULTIPLE CAGE RACKS

Refrigerated Collection Rack

• Manual or Automatic/Manual collection • Maintain samples down to -15°C effectively reducing enzymatic reactions until analyses can be performed & SAMPLING

DELIVERY The Refrigerated Collection Racks are horizontal racks which accommodate up to 12 Rodent Metabolic Cages (not included), see page 134. Urine and feces samples are collected into separate 15 ml conical tubes under each cage.

The racks come completely assembled with a compressor which controls the temperature of the samples, twelve funnels and twelve 15 ml Polymethylpentene Conical Tubes for each cage (144 tubes total). Vertical Multiple Cage Rack The rack framework is made of AISI 304 stainless steel. The nylon casters are extremely durable and allow easy, quiet handling. One • Saves space pair of casters locks for safety and stability.

The Vertical Cage Rack holds up to 12 Single Mouse or Small Rodent The Refrigerated Rack with Automatic Collection automatically Metabolic Cages in three rows of 4 cages. It can also be adjusted to collects and refrigerates or freezes urine samples from metabolic hold 8 Large Rodent Metabolic Cages by removing the runners. This cages at pre-set intervals. It is ideal for automatic, unattended rack takes up a small area in the laboratory by extending upward. sample collection overnight or on weekends and for fraction collection for repeated urine sampling over a short period of time. This stainless steel rack is mounted on swivel casters, two of which lock for safety. Metabolic cages are not included with the rack, see The Refrigerated Rack with Automatic Collection has a geared pages 134 and 136. motor with microprocessor-controlled timing mechanism permitting preprogrammed collection intervals from 10 seconds to 30 Full assembly instructions are included with each rack. hours, with a total of 12 collections. A control/power panel allows automatic or manual operation and has a central power switch and separate. ON/OFF switches for the timing mechanism and Specifications compressor. Supplied with complete instruction manual. Dimensions, H x W x D: Vertical 187 x 126 x 50 cm (73.5 x 49.5 x 19.5 in) Cage Rack Specifications Horizontal 129 x 178 x 63 cm (50.8 x 70.1 x 24.8 in) Dimensions, H x W x D: Cage Rack Rack 135 x 215 x 79 cm (53 x 31 x 85 in) Rack, actual use, allows for 135 x 241 x 79 cm (53 x 31 x 95 in) lengthwise movement of center Order # Product section of Rack ST1 52-6764 Multiple Cage Rack, Vertical Case 160 x 234 x 86 cm (63 x 34 x 92 in) Case Weight: Rack with Automatic/ 340 kg (750 lbs) Manual Collection Rack with Manual Collection 317 kg (700 lbs) Power 115 VAC, 60 Hz

Order # Product ST1 52-6814 Refrigerated Collection Rack with Automatic/Manual Collection ST1 52-6821 Refrigerated Collection Rack with Manual Collection Rack

138 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com DOSING CATHETERS & GAGS

Small Dosing Catheters (PVC)

These catheters are for dosing very small animals or neonates. Each has a Luer fitting. The 1.02 mm OD catheter has a side eye. The 0.61 mm OD catheter has an open tube end, which can be cut to the required length. All catheters are individually packaged, non-sterile.

Order # Product ST1 34-0347 Dosing Catheter, 1.02 mm OD, 0.58 mm ID, 40 mm length, pkg. of 1 ST1 34-0348 Dosing Catheter, 0.61 mm OD, 0.28 mm ID, 40 mm length, pkg. of 1

ST1 34-0340

Dosing Catheters (rubber)

Dosing Catheters (Rubber)

Molded rubber with side eye outlets near the tip. Other sizes of rubber catheters available on request. For easy connection to a syringe, see the Catheter Adaptors on page 148.

® Order # Product Portex Catheters DELIVERY & SAMPLING ST1 34-0334 Dosing Catheter, 8 Fr, 39 cm, 1 Eye, pkg. of 5 We supply the complete Portex® range of catheters and esophageal ST1 34-0335 Dosing Catheter, 10 Fr, 39 cm, 1 Eye, pkg. of 5 tubes. Available in sterile, single use packs. Supplied in a package of ST1 34-0337 Dosing Catheter, 12 Fr, 38 cm, 1 Eye, pkg. of 5 10 catheters. ST1 34-0336 Dosing Catheter, 14 Fr, 35 cm, 1 Eye, pkg. of 5 ST1 34-0338 Dosing Catheter, 20 Fr, 38 cm, 1 Eye, pkg. of 1 Order # Product ST1 34-0339 Dosing Catheter, 28 Fr, 77 cm, 1 Eye, pkg. of 1 ST1 34-0341 Portex® Catheters, Luer, 8 Fr, 390 mm long, pkg. of 10

ST1 34-0343 ST1 34-0331

ST1 34-0344

Dosing Catheters (PVC) Dosing Gags

All catheters are individually packaged, non-sterile. Each catheter These gags are an invaluable aid when introducing dosing catheters has one side eye and a Luer fitting. Minimum order of 10. into the esophageal tract. Full instructions for use, including checks for correct positioning, are included. They are available in three Order # Product sizes, and supplied individually. ST1 34-0343 Dosing Catheter, 4.5 Fr, 60 mm, pkg. of 1 ST1 34-0345 Dosing Catheter, 6 Fr, 300 mm, pkg. of 1 Order # Product ST1 34-0342 Dosing Catheter, 8 Fr, 100 mm, pkg. of 1 ST1 34-0331 Dosing Gags, Size 1, for guinea pigs, rabbits, cats, etc., pkg. of 1 ST1 34-0344 Dosing Catheter, 8 Fr, 120 mm, pkg. of 1 ST1 34-0332 Dosing Gags, Size 2, for dogs, etc., pkg. of 1 ST1 34-0346 Dosing Catheter, 10 Fr, 100 mm, pkg. of 1 ST1 34-0333 Dosing Gags, Size 3, for pigs, etc., pkg. of 1

Portex is a registered trademark of Smiths Medical ASD, Inc.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 139 ANIMAL FEEDING NEEDLES

Disposable Animal Feeding Needles & SAMPLING DELIVERY

Instech Stainless Steel Feeding Needles Disposable Animal Feeding Needles

• For rodent oral gavage • Sterile, non-toxic, non-pyrogenic

• Sterile These feeding needles feature plastic luer hubs and silicone tips. • Autoclavable Supplied straight, but can be bent to desired shape. Available in three sizes. They are supplied in sterile, Tyvek® peel pouches While many researchers prefer the convenience of disposable containing five needles each. plastic feeding tubes, others may prefer to use the traditional metal types. These feeding needles are comprised of a stainless steel tube and ball and a nick-plated brass hub. They comply with ISO594 Order # Gauge Length 1 specifications. The sizes range from 24 gauge to 16 gauge to cover ST1 59-8635 20 38.1 mm (1 ⁄2 in) rodents from mouse pups to large rats. ST1 59-8636 18 50.8 mm (2 in) ST1 59-8637 15 76.2 mm (3 in) All needles are sold straight, but can easily be bent for optimized use. They are supplied sterile in a package of 6.

Stainless Steel Feeding Needles, pkg. of 6. Bulb Diam. Length Order # Gauge mm (in) mm (in) Shape Animal Species ST1 75-0280 24 ga 1.2 mm 25 (0.98) Straight Mouse ST1 75-0281 22 ga 1.2 mm 25 (0.98) Straight Mouse ST1 75-0282 20 ga 2.0 mm 25 (0.98) Straight Mouse, Rat Pup ST1 75-0283 20 ga 2.0 mm 38 (1.5) Straight Mouse, Rat Pup ST1 75-0284 18 ga 2.0 mm 51 (2.0) Straight Rat (200 to 250 g) ST1 75-0285 18 ga 2.0 mm 76 (2.9) Straight Rat (200 to 300 g) ST1 75-0286 16 ga 2.8 mm 76 (2.9) Straight Rat (250 to 300 g)

Tyvek is a registered trademark of: E.I. Du Pont de Nemours and Company Corp.

140 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com ANIMAL FEEDING NEEDLES

Many researchers have converted to the plastic feeding tube for the Plastic Feeding Tubes increased tubing flexibility which reduces trauma and performation and for the simplicity of a low cost, disposable device. These tubes feature medical grade materials designed to minimize the risk of interactions with test compounds. The tube is constructed of polypropylene which is the same material used in plastic syringes. The soft, bulb-shaped tip is fabricated from elastomer (though virtually none of the tip is in the fluid path). The soft, bulb-shaped tip is designed to prevent inadvertent tube placement in the trachea and to reduce the risk of trauma and performation. Instead of using the solvents and glues used by other plastic feeding tubes, the manufacturing process insert-molds the Luer and the rubber tip directly to the tube. This method improves the bond strength of these connections, reduces leaks and detachments and assures more consistent quality. These feeding tubes are available in a variety of diameters and lengths to allow for use in most small laboratory animals. The package of 50 contains 10 sterile pouches of 5. The package of 250 contains 50 sterile pouches of 5.

Specifications* Material Medical-grade polypropylene (Luer and tube), elastomer (tip) Instech Plastic Feeding Tubes Tube Sizes 22, 20, 18, 15 and 13 ga Tube OD x ID & color • Flexibility reduces risk of perforation 22 ga 0.7 mm x 0.4 mm, black DELIVERY & SAMPLING • Soft rubber tip minimizes trauma 20 ga 0.9 mm x 0.5 mm, yellow • No labor-intensive cleaning/sterilizing 18 ga 1.2 mm x 0.7 mm, pink • Reduced risk of residual compound 15 ga 1.8 mm x 1.2 mm, blue • Reduced risk of cross-contamination 13 ga 2.4 mm x 1.6 mm, purple • Available in package of 50 or 250

Order # Order # Product Applications

Plastic Rat Rat Rat Rat Rat Guinea Pkg. of 50 Pkg. of 250 Feeding Tubes Mouse Rat Pup (100-150 g) (150-200 g) (200-250 g) (250-300 g) (>300 g) Hamster Pig Rabbit ST1 75-0266 ST1 72-4453 22 ga x 25 mm long ✓ ✓ ST1 75-0267 ST1 72-4448 20 ga x 30 mm long ✓ ✓ ST1 75-0268 ST1 72-4449 20 ga x 38 mm long ✓ ✓ ST1 75-0269 ST1 72-4442 18 ga x 30 mm long ✓ ST1 75-0270 ST1 72-4443 18 ga x 38 mm long ✓ ST1 75-0271 ST1 72-4444 18 ga x 50 mm long ✓ ST1 75-0272 ST1 72-4445 18 ga x 75 mm long ✓ ✓ ST1 75-0273 ST1 72-4446 15 ga x 78 mm long ✓ ST1 75-0274 ST1 72-4447 15 ga x 100 mm long ✓ ST1 75-0275 ST1 72-4450 13 ga x 90 mm long ✓ ✓ ✓ ST1 75-0276 ST1 72-4451 13 ga x 150 mm long ✓ ✓ ✓

Tyvek is a registered trademark of: E.I. Du Pont de Nemours and Company Corp.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 141 ANIMAL FEEDING NEEDLES & NON-CORING NEEDLE

Dosing Cannulae Dosing Cannulae Suitable for small animals, reptiles and birds, these cannulae are made of stainless steel with a Luer fitting and a bulbous tip. They can be sterilized and re-used.

Order # Product ST1 34-0326 Dosing Cannula, 200 mm x 12 ga, Lawton curved, pkg. of 2 ST1 34-0327 Dosing Cannula, 125 mm x 14 ga, Lawton curved, pkg. of 2 ST1 34-0316 Dosing Cannula, 75 mm x 16 ga, Curved, pkg. of 3 ST1 34-0317 Dosing Cannula, 75 mm x 16 ga, Straight, pkg. of 3 ST1 34-0318 Dosing Cannula, 50 mm x 18 ga, Curved, pkg. of 3 ST1 34-0319 Dosing Cannula, 50 mm x 18 ga, Straight, pkg. of 3 ST1 34-0320 Dosing Cannula, 25 mm x 20 ga, Curved, pkg. of 3 ST1 34-0321 Dosing Cannula, 25 mm x 20 ga, Straight, pkg. of 3 ST1 34-0322 Dosing Cannula, 38 mm x 20 ga, Curved, pkg. of 3 ST1 34-0323 Dosing Cannula, 38 mm x 20 ga, Straight, pkg. of 3 ST1 34-0324 Dosing Cannula, 38 mm x 22 ga, Curved, pkg. of 3 ST1 34-0325 Dosing Cannula, 38 mm x 22 ga, Straight, pkg. of 3 ST1 34-1400 Dosing Cannula, 1 of each size, pkg. of 12 & SAMPLING DELIVERY

Non-Coring Needle with Micro-Mate Hub These deflected non-coring septum penetration needles are made from stainless steel tubing with a deflected point to minimize or eliminate coring when needles are used to penetrate septa or rubber closures. Micro-Mate® Non-Coring needles were designed with special hubs to provide an easy, secure, leak-proof mating of plastic Luers while minimizing stripping of plastic during repeated use. These needles are available in a variety of sizes and lengths and are ® Non-Coring Needle with Micro-Mate Hub supplied in a package of 12 needles. They are supplied non-sterile and can be autoclaved. These precision made stainless steel needles with deflected (septum) point, and standard female Luer hub are extensively used with micro syringes. They are ideal for applications such as gas and liquid chromatography and nuclear magnetic resonance spectroscopy procedures as well as many others.

Deflected Non-Coring Septum Penetration Needles with Chrome Plated Hub, pkg. of 12 Needle Length (in)

Gauge 1⁄2 in 3⁄4 in 1 in 1 1⁄2 in 2 in 4 in 6 in 8 in 10 in 12 in 26 ga ST1 72-5168 – – – – – – – – – 25 ga – ST1 72-5170 ST1 72-5171 – – – – – – – 23 ga – – ST1 72-5172 – – – – – – – 22 ga – – ST1 72-5173 ST1 72-5174 ST1 72-5175 ST1 72-5176 ST1 72-5177 – – – 21 ga – – ST1 72-5179 – ST1 72-5181 ST1 72-5182 – – – 20 ga – – ST1 72-5183 – ST1 72-5184 ST1 72-5185 ST1 72-5186 ST1 72-5187 – ST1 72-5188 19 ga – – – – ST1 72-5189 ST1 72-5190 ST1 72-5191 – ST1 72-5201 – 18 ga – – – ST1 72-5192 ST1 72-5193 ST1 72-5194 ST1 72-5195 – ST1 72-5200 ST1 72-5196 16 ga – – – – – – ST1 72-5197 – – ST1 72-5199

Deflected Non-Coring Septum Penetration Needles with Micro-Mate Hub, pkg. of 12 Needle Length (in)

Gauge 3⁄8 in 1⁄2 in 3⁄4 in 1 in 1 1⁄2 in 2 in 4 in 6 in 8 in 10 in 12 in 22 ga – – – – – – – ST1 72-5208 – – – 20 ga – – – ST1 72-5204 – – – ST1 72-5205 ST1 72-5206 – ST1 72-5207 18 ga – – – – – – – ST1 72-5202 – – ST1 72-5203

Micro-Mate® is a registered trademark of Cadence, Inc.

142 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com ANIMAL FEEDING NEEDLES & NON-CORING NEEDLE NEEDLES

Reusable Standard Hypodermic Needles REUSABLE HYPODERMIC NEEDLES These regular medical point needles have standard walls and a medical style point. They are for intramuscular, subcutaneous, These Hypodermic Needles are precision made and and other injections and are available in a wide range of gauges designed to ensure strict adherence with U.S. Government and lengths. They have an oversized chrome plated Luerlock hub specification GG-N-196. Points are machine ground to assure and are supplied 12 per package. Needles are supplied non-sterile uniform sharpness and minimal discomfort due to tearing and are autoclavable. of the skin. Precision grinding, micro-bead jet blasting and ultrasonic cleaning assure freedom from burrs and debris. All needle cannulae are fabricated of Type 304 Stainless Steel Specifications for Needles Tubing. They are regular walled needles. Standard Hypodermic, Fine Gauge, Probe Point (Blunt) and Huber Point The needle hubs are brass chrome plated and machine Needle OD OD ID ID Volume Volume made to comply exactly with Luer Taper specifications Gauge (in) (mm) (in) (mm) µl/in µl/mm Z70.1 of the American Standards Association. This assures 33 ga 0.0083 0.21 0.0040 0.11 0.20 0.01 interchangeable fit with mating Luer Slips and Luer Locks 32 ga 0.0093 0.24 0.0043 0.11 0.20 0.01 made by all manufacturers, either in the reusable or disposable style. Contoured hub cavity facilitates cleaning 31 ga 0.0103 0.26 0.0053 0.13 0.34 0.01 and wiring. Each hub carries a gauge number. Needles are 30 ga 0.0123 0.31 0.0063 0.16 0.45 0.02 supplied non-sterile and are autoclavable. 28 ga 0.0143 0.36 0.0073 0.18 0.63 0.02 27 ga 0.0163 0.41 0.0083 0.21 0.80 0.03 26 ga 0.0183 0.46 0.0103 0.26 1.25 0.05 25 ga 0.0225 0.51 0.0103 0.26 1.25 0.05 24 ga 0.0223 0.57 0.0123 0.31 1.80 0.07 23 ga 0.0253 0.64 0.0133 0.34 2.17 0.09 22 ga 0.0283 0.72 0.0163 0.41 3.35 0.13 21 ga 0.0323 0.82 0.0203 0.51 5.19 0.20

20 ga 0.0358 0.91 0.0238 0.60 6.71 0.26 DELIVERY & SAMPLING 19 ga 0.0420 1.07 0.0270 0.69 - - 18 ga 0.0500 1.27 0.0330 0.84 14.08 0.55 17 ga 0.0578 1.47 0.0420 1.07 22.84 0.90 16 ga 0.0650 1.65 0.0470 1.19 28.25 1.11 15 ga 0.0720 1.83 0.0540 1.37 - - 14 ga 0.0830 2.11 0.0630 1.60 51.07 2.01 13 ga 0.0950 2.41 0.0710 1.80 64.63 2.54 12 ga 0.1090 2.77 0.0850 2.16 93.07 3.66 11 ga 0.1200 3.05 0.0940 2.39 113.00 4.45 10 ga 0.1340 3.40 0.1060 2.69 143.28 5.64

Reusable Standard Hypodermic Needles, pkg. of 12 Length Needle 9.5 mm 12.7 mm 19.0 mm 25.4 mm 31.8 mm 38.2 mm 50.8 mm 76.2 mm Gauge (0.375 in) (0.5 in) (0.75 in) (1.0 in) (1.25 in) (1.5 in) (2.0 in) (3.0 in) 28 ga ST1 72-5737 ST1 72-5738 ST1 72-5739 ST1 72-5740 ST1 72-5741 ST1 72-5742 – – 27 ga ST1 72-5731 ST1 59-8523 ST1 59-8525 ST1 59-8526 ST1 72-5735 ST1 72-5736 – – 26 ga ST1 72-5725 ST1 59-8529 ST1 59-8531 ST1 59-8532 ST1 72-5729 ST1 59-8533 – – 25 ga ST1 72-5719 – – ST1 59-8538 ST1 72-5723 – – – 24 ga ST1 72-5712 ST1 59-8541 ST1 59-8543 ST1 59-8544 ST1 59-8545 ST1 59-8546 ST1 72-5718 – 23 ga ST1 72-5705 ST1 59-8547 ST1 59-8549 ST1 59-8550 ST1 59-8551 ST1 59-8552 ST1 59-8553 – 22 ga ST1 72-5697 ST1 72-5698 ST1 72-5699 ST1 59-8554 ST1 59-8555 ST1 59-8556 ST1 59-8557 ST1 72-5704 21 ga ST1 72-5689 ST1 72-5690 ST1 72-5691 ST1 59-8559 ST1 59-8560 ST1 59-8561 ST1 59-8562 ST1 72-5696 20 ga ST1 72-5681 ST1 72-5682 ST1 72-5683 ST1 59-8563 ST1 59-8564 ST1 59-8565 ST1 59-8566 ST1 72-5688 19 ga – – – – ST1 59-8569 ST1 59-8570 ST1 59-8571 – 18 ga ST1 72-5673 ST1 72-5674 ST1 72-5675 ST1 59-8573 ST1 72-5677 ST1 59-8574 ST1 59-8575 ST1 72-5680 17 ga ST1 72-5665 ST1 72-5666 ST1 72-5667 ST1 72-5668 ST1 72-5669 ST1 72-5670 ST1 59-8576 ST1 72-5672 16 ga ST1 72-5657 ST1 72-5658 ST1 72-5659 ST1 59-8590 ST1 72-5661 ST1 72-5662 ST1 59-8593 ST1 59-8595 15 ga – – – ST1 59-8598 – – ST1 59-8601 ST1 59-8603 14 ga ST1 72-5649 ST1 72-5650 ST1 72-5651 ST1 59-8606 ST1 72-5653 ST1 72-5654 ST1 59-8609 ST1 59-8611 13 ga – – ST1 72-5643 ST1 72-5644 ST1 72-5645 ST1 72-5646 ST1 72-5647 ST1 72-5648 12 ga – – ST1 72-5637 ST1 59-8614 ST1 72-5639 ST1 72-5640 ST1 59-8617 ST1 59-8619 11 ga – – ST1 72-5631 ST1 72-5632 ST1 72-5633 ST1 72-5634 ST1 72-5635 ST1 72-5636 10 ga – – ST1 72-5625 ST1 72-5626 ST1 72-5627 ST1 72-5628 ST1 72-5629 ST1 72-5630

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 143 NEEDLES

Reusable Fine Gauge Needles with Sharp Hypodermic or Blunt Tip

These fine gauge needles are regular walled with either a sharp hypodermic tip or blunt tip. Their small size allows insertion into Sharp Hypodermic Tip very fine vessels or tubing. These needles are available in 4 gauges of several lengths and are packaged with a special protector. The needles also have an oversized chrome plated Luer lock hub. They Blunt Tip are supplied 12 per package. These needles are supplied non-sterile and are autoclavable.

Reusable Fine Gauge Needles, pkg. of 12

Needle Length Needle Type Gauge 9.5 mm (0.375 in) 12.7 mm (0.5 in) 15.9 mm (0.625 in) 19.0 mm (0.75 in) 25.4 mm (1.0 in) Sharp, Hypodermic 33 ga ST1 72-5526 ST1 72-5527 ST1 72-5528 ST1 72-5529 ST1 72-5530 Sharp, Hypodermic 32 ga ST1 72-5521 ST1 72-5522 ST1 72-5523 ST1 72-5524 ST1 72-5525 Sharp, Hypodermic 31 ga ST1 72-5516 ST1 72-5517 ST1 72-5518 ST1 72-5519 ST1 72-5520 Sharp, Hypodermic 30 ga ST1 72-5511 ST1 72-5512 ST1 72-5513 ST1 72-5514 ST1 72-5515 Blunt 33 ga ST1 72-5506 ST1 72-5507 ST1 72-5508 ST1 72-5509 ST1 72-5510 Blunt 32 ga ST1 72-5501 ST1 72-5502 ST1 72-5503 ST1 72-5504 ST1 72-5505

& SAMPLING Blunt 31 ga ST1 72-5496 ST1 72-5497 ST1 72-5498 ST1 72-5499 ST1 72-5500 DELIVERY Blunt 30 ga ST1 72-5491 ST1 72-5492 ST1 72-5493 ST1 72-5494 ST1 72-5495

Reusable Probe Point Needles

These needles have a flat blunt tip which is ideal for dispensing, aspirating, and obtaining liquid samples. They are also useful for making cannulae when inserted into Polyethylene tubing and other tubing. The needles are regular walled with oversized chrome Blunt Tip plated Luer lock hubs. They are supplied 12 per package. These needles are supplied non-sterile and are autoclavable.

Reusable Probe Point Needles, pkg. of 12 Needle Length Needle 9.5 mm 12.7 mm 19.0 mm 25.4 mm 31.8 mm 38.2 mm 50.8 mm 76.2 mm Gauge (0.375 in) (0.5 in) (0.75 in) (1.0 in) (1.25 in) (1.5 in) (2.0 in) (3.0 in) 28 ga ST1 72-5483 ST1 72-5484 ST1 72-5485 ST1 72-5486 ST1 72-5487 ST1 72-5488 ST1 72-5489 ST1 72-5490 27 ga ST1 72-5475 ST1 72-5476 ST1 72-5477 ST1 72-5478 ST1 72-5479 ST1 72-5480 ST1 72-5481 ST1 72-5482 26 ga ST1 72-5467 ST1 72-5468 ST1 72-5469 ST1 72-5470 ST1 72-5471 ST1 72-5472 ST1 72-5473 ST1 72-5474 25 ga ST1 72-5459 ST1 72-5460 ST1 72-5461 ST1 72-5462 ST1 72-5463 ST1 72-5464 ST1 72-5465 ST1 72-5466 24 ga ST1 72-5451 ST1 72-5452 ST1 72-5453 ST1 72-5454 ST1 72-5455 ST1 72-5456 ST1 72-5457 ST1 72-5458 23 ga ST1 72-5443 ST1 72-5444 ST1 72-5445 ST1 72-5446 ST1 72-5447 ST1 72-5448 ST1 72-5449 ST1 72-5450 22 ga ST1 72-5435 ST1 72-5436 ST1 72-5437 ST1 72-5438 ST1 72-5439 ST1 72-5440 ST1 72-5441 ST1 72-5442 21 ga ST1 72-5427 ST1 72-5428 ST1 72-5429 ST1 72-5430 ST1 72-5431 ST1 72-5432 ST1 72-5433 ST1 72-5434 20 ga ST1 72-5419 ST1 72-5420 ST1 72-5421 ST1 72-5422 ST1 72-5423 ST1 72-5424 ST1 72-5425 ST1 72-5426 18 ga ST1 72-5411 ST1 72-5412 ST1 72-5413 ST1 72-5414 ST1 72-5415 ST1 72-5416 ST1 72-5417 ST1 72-5418 17 ga ST1 72-5403 ST1 72-5404 ST1 72-5405 ST1 72-5406 ST1 72-5407 ST1 72-5408 ST1 72-5409 ST1 72-5410 16 ga ST1 72-5395 ST1 72-5396 ST1 72-5397 ST1 72-5398 ST1 72-5399 ST1 72-5400 ST1 72-5401 ST1 72-5402 14 ga ST1 72-5387 ST1 72-5388 ST1 72-5389 ST1 72-5390 ST1 72-5391 ST1 72-5392 ST1 72-5393 ST1 72-5394 13 ga ST1 72-5379 ST1 72-5380 ST1 72-5381 ST1 72-5382 ST1 72-5383 ST1 72-5384 ST1 72-5385 ST1 72-5386 12 ga ST1 72-5371 ST1 72-5372 ST1 72-5373 ST1 72-5374 ST1 72-5375 ST1 72-5376 ST1 72-5377 ST1 72-5378 11 ga ST1 72-5363 ST1 72-5364 ST1 72-5365 ST1 72-5366 ST1 72-5367 ST1 72-5368 ST1 72-5369 ST1 72-5370 10 ga ST1 72-5355 ST1 72-5356 ST1 72-5357 ST1 72-5358 ST1 72-5359 ST1 72-5360 ST1 72-5361 ST1 72-5362

144 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com NEEDLES

Reusable Huber Point Needles

Huber point needles have a deflected bevel top making the cutting surface approximately perpendicular to the needle shaft. This design reduces the coring of tissue and septa samples. The needles are regular walled with oversized chrome plated Luer lock hubs. Huber Tip They are supplied 12 per package. These needles are supplied non-sterile and are autoclavable.

Reusable Huber Point Needles, pkg. of 12 Needle Length Needle 9.5 mm 12.7 mm 19.0 mm 25.4 mm 31.8 mm 38.2 mm 50.8 mm 76.2 mm Gauge (0.375 in) (0.5 in) (0.75 in) (1.0 in) (1.25 in) (1.5 in) (2.0 in) (3.0 in) 28 ga ST1 72-5619 ST1 72-5620 ST1 72-5621 ST1 72-5622 ST1 72-5623 ST1 72-5624 – – 27 ga ST1 72-5613 ST1 72-5614 ST1 72-5615 ST1 72-5616 ST1 72-5617 ST1 72-5618 – – 26 ga ST1 72-5607 ST1 72-5608 ST1 72-5609 ST1 72-5610 ST1 72-5611 ST1 72-5612 – – 25 ga ST1 72-5601 ST1 72-5602 ST1 72-5603 ST1 72-5604 ST1 72-5605 ST1 72-5606 – – 24 ga ST1 72-5594 ST1 72-5595 ST1 72-5596 ST1 72-5597 ST1 72-5598 ST1 72-5599 ST1 72-5600 – 23 ga ST1 72-5587 ST1 72-5588 ST1 72-5589 ST1 72-5590 ST1 72-5591 ST1 72-5592 ST1 72-5593 – 22 ga ST1 72-5579 ST1 72-5580 ST1 72-5581 ST1 72-5582 ST1 72-5583 ST1 72-5584 ST1 72-5585 ST1 72-5586 21 ga ST1 72-5571 ST1 72-5572 ST1 72-5573 ST1 72-5574 ST1 72-5575 ST1 72-5576 ST1 72-5577 ST1 72-5578

20 ga ST1 72-5563 ST1 72-5564 ST1 72-5565 ST1 72-5566 ST1 72-5567 ST1 72-5568 ST1 72-5569 ST1 72-5570 18 ga ST1 72-5555 ST1 72-5556 ST1 72-5557 ST1 72-5558 ST1 72-5559 ST1 72-5560 ST1 72-5561 ST1 72-5562 17 ga ST1 72-5547 ST1 72-5548 ST1 72-5549 ST1 72-5550 ST1 72-5551 ST1 72-5552 ST1 72-5553 ST1 72-5554 16 ga ST1 72-5539 ST1 72-5540 ST1 72-5541 ST1 72-5542 ST1 72-5543 ST1 72-5544 ST1 72-5545 ST1 72-5546 14 ga DELIVERY ST1 72-5531 ST1 72-5532 ST1 72-5533 ST1 72-5534 ST1 72-5535 ST1 72-5536 ST1 72-5537 ST1 72-5538 & SAMPLING

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 145 NEEDLES

Blunt Needles with Sterile Single Use Needles Aluminum Hub A wide range of sizes and styles of Monoject™1-1 Needles are available. Each needle is packaged in a rigid pack with a tamper-evident 1-1 sword. All hypodermic needles feature an ultrasharp tri-beveled anti-coring stainless steel needle and are available in one of three bevels: regular hypodermic bevel (A), intermediate bevel (IN) and short bevel (B).

1-2

1-2 A Regular Bevel (A) For all intramuscular1-1 and subcutaneous injections.

1-3 Blunt Needles with Aluminum Hub IN Intermediate Bevel (IN) 1-3 For testing and for injections in the skin. • Stainless steel cannula 1-2 • Aluminum Luer lock hub • Color-coded needle sheath with charcoal grey cap

& SAMPLING B Short Bevel (B) DELIVERY • Autoclavable in rigid pack for use in For intravenous1-4 and intra-arterial OR/procedure packs injections, also for nerve blocks. • Sterile 1-4 1-3 These cannulae have a blunt tip and are available in 9 sizes. Select from a box of 25 or a case of 100.

Blunt Needles with Aluminum Hub Length Bevel Box 25 Case 100 Gauge (in) Type Order # Order # 15 ga 1.5 Blunt ST1 72-2341 ST1 72-2350 1-4 16 ga 1.5 Blunt ST1 72-2342 ST1 72-2351 17 ga 1.5 Blunt ST1 72-2343 ST1 72-2352 18 ga 1.0 Blunt ST1 72-2344 ST1 72-2353 19 ga 1.5 Blunt ST1 72-2345 ST1 72-2354 20 ga 1.5 Blunt ST1 72-2346 ST1 72-2355 21 ga 1.0 Blunt ST1 72-2347 ST1 72-2356 22 ga 1.5 Blunt ST1 72-2348 ST1 72-2357 23 ga 1.0 Blunt ST1 72-2349 ST1 72-2358

Monoject is a registered trademark of Covidien.

146 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com NEEDLES

Hypodermic Hypodermic Needles Hypodermic Needles with Hypodermic Needles Needles with with Aluminum Hub Polypropylene Hub with Polypropylene Aluminum Hub Hub • Ultra-sharp, tri-beveled, anti-coring, stainless • Ultra-sharp, tri-beveled, steel needle anti-coring, stainless • Precision machined steel needle Luer lock hub • Translucent, color • Autoclavable in rigid coded Luer lock pack for use in OR/ hub shows blood procedure packs “flashback” • Sterile • Epoxy attachment of needle to hub assures These needles are available compatibility with with either a regular (A), specialized drugs intermediate (IN) or short (B) bevel tip type in various sizes. • Color-coded cap on rigid pack with clear needle sheath Regular (A) bevel is for intramuscular and subcutaneous injections. Intermediate (IN) Bevel is for intradermal injections. Short (B) bevel • Autoclavable in rigid pack for use in OR/procedure packs is for intravenous or intrarterial applications and nerve blocks. A • Sterile selection of thin walled needles is also available. Supplied sterile in a box of 100 or a case of 1000. These needles are available with two different tip types and various

sizes. Regular (A) bevel is for intramuscular and subcutaneous Hypodermic Needles with Aluminum Hub injections. Short (B) bevel is for intravenous or intrarterial applications and nerve blocks. A selection of thin walled needles is Bevel Box 100 Case 1000 also available. Select from a box of 100 or a case of 1000. Gauge Length (in) Type Order # Order #

14 ga 1.0 IN ST1 72-2277 ST1 72-2309 DELIVERY & SAMPLING 14 ga 1.5 IN ST1 72-2278 ST1 72-2310 Hypodermic Needles with Polypropylene Hub 14 ga 2.0 IN ST1 72-2279 ST1 72-2311 Length Bevel Box 100 Case 1000 Gauge (in) Type Order # Order # 15 ga 1.5 B ST1 72-2280 ST1 72-2312 18 ga 1.0 A ST1 72-2231 ST1 72-2254 16 ga 0.625 B ST1 72-2281 ST1 72-2313 18 ga 1.0 B ST1 72-2232 ST1 72-2255 16 ga 1.0 A ST1 72-2282 ST1 72-2314 18 ga 1.5 B ST1 72-2233 ST1 72-2256 16 ga 1.5 A ST1 72-2283 ST1 72-2315 19 TW* 1.0 B ST1 72-2234 ST1 72-2257 16 ga 1.5 B ST1 72-2284 ST1 72-2316 19 TW* 1.5 B ST1 72-2235 ST1 72-2258 18 ga 1.0 A ST1 72-2285 ST1 72-2317 19 TW* 1.0 A ST1 72-2236 ST1 72-2259 18 ga 1.0 B ST1 72-2286 ST1 72-2318 20 ga 1.0 A ST1 72-2237 ST1 72-2260 18 ga 1.5 A ST1 72-2287 ST1 72-2319 20 ga 1.5 A ST1 72-2238 ST1 72-2261 18 ga 1.5 B ST1 72-2288 ST1 72-2320 20 ga 1.0 B ST1 72-2239 ST1 72-2262 20 ga 1.0 A ST1 72-2289 ST1 72-2321 20 ga 1.5 B ST1 72-2240 ST1 72-2263 20 ga 1.0 B ST1 72-2290 ST1 72-2322 21 ga 1.0 A ST1 72-2241 ST1 72-2264 20 ga 1.5 A ST1 72-2291 ST1 72-2323 21 ga 1.5 A ST1 72-2242 ST1 72-2265 20 ga 1.5 B ST1 72-2292 ST1 72-2324 21 ga 1.5 B ST1 72-2243 ST1 72-2266 20 ga 3.0 A ST1 72-2293 – 22 ga 1.0 A ST1 72-2244 ST1 72-2267 21 ga 1.0 A – – 22 ga 1.5 A ST1 72-2245 ST1 72-2268 21 ga 1.5 A – – 22 ga 1.5 B ST1 72-2246 ST1 72-2269 21 ga 2.0 A – – 23 ga 0.75 A ST1 72-2247 ST1 72-2270 22 ga 1.0 A ST1 72-2297 ST1 72-2329 23 ga 1.0 A ST1 72-2248 ST1 72-2271 22 ga 1.5 A ST1 72-2298 ST1 72-2330 25 ga 0.625 A ST1 72-2249 ST1 72-2272 23 ga 1.0 A ST1 72-2299 ST1 72-2331 25 ga 1.0 A ST1 72-2250 ST1 72-2273 25 ga 0.625 A ST1 72-2300 ST1 72-2332 25 ga 1.5 A ST1 72-2251 ST1 72-2274 25 ga 1.25 A ST1 72-2301 ST1 72-2333 26 ga 0.5 B ST1 72-2252 ST1 72-2275 25 ga 2.0 A ST1 72-2302 ST1 72-2334 30 ga 0.75 A ST1 72-2253 ST1 72-2276 27 ga 0.5 IN ST1 72-2303 ST1 72-2335 27 ga 1.25 A ST1 72-2304 ST1 72-2336

**Package of 300 Needles

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 147 NEEDLES

35 ga Ultra Fine Micro Injection Injection Needle Needles

28 ga

32 ga Micro Injection Needles

• Reduces clotting & trauma • Micro size is ideal for working with smaller species • Provides greater volume control

& SAMPLING • Stainless steel needle with 12° bevel point at tip DELIVERY Ultra Fine Injection Needles • Autoclavable

35 & 34 Gauge Needles These Micro Injection Needles are ideal for portal vein, thymus, These Ultra Fine Injection Needles substantially reduce pain and and bile duct injections. They can also be used for blood/fluid

trauma. The beveled tip needles can be used for direct injection. extractions. Their small size helps to reduce blood clotting and The blunt needles can be use for connecting micro-catheters for trauma at the injection site. They should be used with the tubing. Available sterile or non-sterile in packages of 20 needles. ST1 62-0044 1 cc Plastic Syringe listed below. Needles and syringe are supplied individually.

Dia. Length Hub Order # Gauge Type (mm) (mm) &Cap Packaged Order # Product Sterilized ST1 62-0042 Micro Injection Needle, 32 ga, Straight, 0.009 x 0.003 in (ODxID), 10 mm long, pkg. of 1 ST1 72-0079 34 Beveled 0.20 7 Yes Individually Packed, ST1 62-0043 Micro Injection Needle, 32 ga, 45° Angled, pkg. of 20 0.009 x 0.003 in (ODxID), 10 mm long, pkg. of 1 ST1 72-0080 35 Beveled 0.15 5 Yes Individually ST1 62-0044 Plastic Syringe, 1 cc, For Use with ST1 62-0042 Packed, & ST1 62-0043 Micro Injection Needles, pkg. of 1 pkg. of 20 Non-Sterilized Skin Tunneling Needles ST1 72-0081 34 Beveled 0.20 7 Yes Pkg. of 20 ST1 72-0082 34 Blunt 0.20 7 Yes Pkg. of 20 • Assure minimal trauma ST1 72-0083 34 Blunt 0.20 15 No Pkg. of 20 to the animal ST1 72-0084 35 Beveled 0.15 5 Yes Pkg. of 20 • Reduce the number of ST1 72-0085 35 Blunt 0.15 10 Yes Pkg. of 20 skin incisions and the ST1 72-0086 35 Blunt 0.15 10 No Pkg. of 20 time required to make a tunnel

Catheter Adapter Catheter Adapter These needles provide a quick and easy method of making subcutaneous tunnels in research animals for routing catheters and This adapter enables a Luer electrode leads to convenient exterior sites. They are constructed of syringe to be inserted into a tempered heavy wall stainless steel tubing and come with semi- wide mouth catheter. The luer blunt 45° bevel points. The needles are made with a through-hole lock adaptor is fused into the in the handle, which is a continuation of the needle lumen, to allow connector. Fits catheters from catheter feed-through. For bundles of catheters and electrode leads 10 french to 28 french (3.3 to 9.3 that are too large for the lumen of the needles, suture wire can be mm OD). They are individually passed through the needles and used to pull the bundles through wrapped and are non-sterile. the subcutaneous tunnel. Supplied in a set of 3. Supplied in packs of 10.

Order # OD x ID Lengths

1 1 Order # Product ST1 72-0680 3.2 x 2.5 mm ( ⁄8 x ⁄10 in) 15.2, 22.9, 30.5 cm (6, 9, 12 in) 3 1 ST1 34-0330 Catheter Adapter, pkg. of 10 ST1 72-0679 4.8 x 3.2 mm ( ⁄ 16 x ⁄8 in) 22.9, 30.5, 40.6 cm (9, 12, 16 in)

148 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com VASCULAR OCCLUDERS

Vascular Occluders Lumen Diameter Cuff Width* Cuff Thickness*

Order # Standard Occluders ST1 72-6115 1.5 mm 5 mm 1.5 mm ST1 62-0109 2 mm 5 mm 1.5 mm ST1 62-0110 3 mm 5 mm 1.5 mm ST1 62-0111 4 mm 5 mm 2 mm ST1 62-0112 5 mm 5 mm 2 mm ST1 62-0113 6 mm 7 mm 2 mm ST1 62-0114 8 mm 7 mm 2 mm ST1 62-0115 10 mm 8 mm 2 mm ST1 62-0116 12 mm 8 mm 2.5 mm ST1 62-0117 14 mm 8 mm 2.5 mm ST1 62-0118 16 mm 12 mm 2.5 mm Vascular Occluders ST1 62-0119 20 mm 12 mm 2.5 mm ST1 62-0120 24 mm 12 mm 2.5 mm • Total or partial occlusion Heavy-Duty Occluders

• Reliable determination of zero-flow baseline in ST1 62-0121 10 mm 9 mm 4 mm blood flow measurements ST1 62-0122 12 mm 9 mm 4 mm • For acute or chronic studies ST1 62-0123 14 mm 9 mm 4 mm ST1 62-0124 16 mm 13 mm 4 mm • Autoclavable DELIVERY ST1 62-0125 20 mm 13 mm 4 mm & SAMPLING These vascular occluders are made entirely of silicone rubber, a ST1 62-0126 24 mm 13 mm 4 mm material proven to be physiologically compatible. The occluder is * Approximate dimensions. a cuff and tube de­sign. The cuff is secured around vessel or soft tissue organ using suture material. The tube is externalized to the animal at the desired site. The site need not be near the occlusion location. To occlude the vessel, simply inject air or water in the actuating tubing with a syringe. This inflates the cuff diaphragm which occludes the vessel. To deflate, simply withdraw the air or water. The response is very rapid and may be maintained for several hours or as long as the occluder is pressurized. Occlusion is accomplished without traction on the vessel or displacement of surrounding tissues. Both standard and heavy duty occluders are offered. They are supplied with 90 cm actuating tubing. Other lengths are available by special order. Tubing diameter depends on cuff size. For cuffs measuring from 2 mm to 8 mm, the tubing measures 0.76 mm ID x 1.6 mm OD (0.030 x 0.065 in). For cuffs measuring from 10 mm to 24 mm, the tubing measures 1 mm ID x 2.1 mm OD (0.040 x 0.085 in).

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 149 VASCULAR ACCESS PORTS

Vascular Access Ports Applications Vascular Access Port Size Species Rodent Small Intermediate Large Mouse ✓ Rat ✓ Ferret ✓ Large NHP (< 4 kg) ✓ Rodent NHP (> 4 kg) ✓ Intermediate Rabbit ✓ Small Dog (< 14 kg) ✓ Dog (> 14 kg) ✓ ✓ Pig (ear) ✓ Pig (scapulae) ✓ Solomon Soloport™ Vascular Access Ports Rodent Vascular Access Ports • Easy to Use • MRI compatible • For use with rodents and other small species • 1 French Catheter with small stainless steel port for mice The vascular access port has evolved from being an intravascular access port into a multi-purpose access port for use in intestinal, Specifications & SAMPLING biliary, intraspinal, cranial, ventricular, and other applications. DELIVERY It is available in a variety of configurations for most species Port Model Polysulfone or stainless steel (72-4452 only) and catheter sizes. The catheter may be pre-attached during Port Volume 0.13 ml manufacture or attached intraoperatively by the surgeon. These Dimensions: ports are fabricated from the highest quality biomaterials. Height 0.7 cm (0.3 in) Top Diameter 1.0 cm (0.4 in) Ports are entirely implanted catheter devices which do not exit through the animal’s skin. There is little concern about the animal Base Diameter 1.7 cm (0.7 in) disturbing the port thereby obviating the need for a jacket or other Weight (port body) 2.6 g protective apparatus. Because there is no chronic exit site wound, Punctures with 22 Ga 1000 infection risks associated with ports are considerably lower than Huber Point Needle with external catheters. The use of ports has provided many new Catheter Length 30 cm (12 in), with 2 retention beads research opportunities, and it represents a refined technique which Sterilization Sterilization EtO; CBAS® and PU are sterilizable has reduced animal use and minimized stress. by EtO only The port was originally intended for intermittent bolus infusions and periodic sampling and access, but it is now widely used in Rodent Vascular Access Ports, pkg. of 1 protracted and continuous infusions. The port is also used in a Silastic® CBAS®-coated tethered model for longer boluses (one hour, for example) or for Size, Fr Catheters PU Uncoated PU intermittent periods of blood pressure monitoring. Pre-Attached Catheters 1 Fr – – ST1 72-4452** Catheter Biomaterials 2 Fr ST1 72-4375* – – 3 Fr The field of biomaterials for intravascular catheters has ST1 72-4376 ST1 72-4381 ST1 72-4386 moved relatively slowly over the past three decades. Silicone 3.5 Fr ST1 72-4377 ST1 72-4382 ST1 72-4387 rubber continues to be the most common material; however, 5 Fr ST1 72-4378 ST1 72-4383 ST1 72-4388 polyurethanes have proven to be more hemocompatible than 7 Fr – ST1 72-4384 ST1 72-4389 silicone. Furthermore the CBAS® heparin coated polyurethane Detachable Catheters has proven to be the most thromboresistant material of all 3 Fr ST1 72-4390 ST1 72-4394 ST1 72-4398 available technologies. This catalog offers a full range of silicone, 3.5 Fr ST1 72-4391 ST1 72-4395 ST1 72-4399 polyurethane, and CBAS®-coated polyurethane catheters in sizes for 5 Fr ST1 72-4392 ST1 72-4396 ST1 72-4400 all species. 7 Fr ST1 72-4393 ST1 72-4397 ST1 72-4401

Round Tips *Note: Catheter has a bevel tip. **Note: This model is specially made for mice from stainless steel. It is not MRI Another vital catheter feature is the round distal tip. Both data and compatible. intuition confirm the benefits. The round tip is less traumatic to the intimal lining of blood vessels. Square cut or bevel cut catheters have sharp edges which irritate the blood vessel’s intimal lining thus hastening the host’s thrombogenic response. Round tips are available on polyurethane and CBAS®-coated polyurethane catheters. CBAS® Long-Term Heparin Coating Soloport is a trademark of Solomon Scientific. See page 124 for details. Carmeda and CBAS are registered trademarks of Carmeda AB. Silastic is a registered trademark of Dow Corning Corporation.

150 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com VASCULAR ACCESS PORTS

Small Titanium Vascular Access Ports Intermediate Vascular Access Ports

Solomon Small Vascular Access Ports Solomon Intermediate Vascular Access Ports

• For use with small primates, rodents and other • For use with small primates and small animals including small species large rodents and rabbits

Specifications Specifications Port Model Titanium Port Model Titanium Port Volume 0.13 ml Port Volume 0.38 ml

Dimensions Dimensions DELIVERY Height 0.7 cm (0.3 in) Height 1.0 cm (0.4 in) & SAMPLING Top Diameter 1.0 cm (0.4 in) Top Diameter 1.2 cm (0.5 in) Base Diameter 1.7 cm (0.7 in) Base Diameter 2.3 cm (0.9 in) Weight (port body) 2.9 g Weight (port body) 6.7 g Punctures with 22 Ga 1000 Punctures with 22 Ga 2000 Huber Point Needle Huber Point Needle Catheter Length 60 cm (24 in), with 2 retention beads Catheter Length 60 cm (24 in), with 2 retention beads Sterilization Sterilization EtO; CBAS® and PU are sterilizable Sterilization Sterilization EtO; CBAS® and PU are sterilizable by EtO only by EtO only

Small Vascular Access Ports, pkg. of 1 Intermediate Vascular Access Ports, pkg. of 1 Silastic® CBAS®-coated Silastic® CBAS®-coated Size, Fr Catheters PU Uncoated PU Size, Fr Catheters PU Uncoated PU Pre-Attached Catheters Pre-Attached Catheters 2 Fr ST1 72-4348 - - 3 Fr ST1 72-4324 ST1 72-4328 ST1 72-4332 3 Fr ST1 72-4349 ST1 72-4354 ST1 72-4359 3.5 Fr ST1 72-4325 ST1 72-4329 ST1 72-4333 3.5 Fr ST1 72-4350 ST1 72-4355 ST1 72-4360 5 Fr ST1 72-4326 ST1 72-4330 ST1 72-4334 5 Fr ST1 72-4351 ST1 72-4356 ST1 72-4361 7 Fr ST1 72-4327 ST1 72-4331 ST1 72-4335 7 Fr ST1 72-4352 ST1 72-4357 ST1 72-4362 Detachable Catheters Detachable Catheters 3 Fr ST1 72-4336 ST1 72-4340 ST1 72-4344 3 Fr ST1 72-4363 ST1 72-4367 ST1 72-4371 3.5 Fr ST1 72-4337 ST1 72-4341 ST1 72-4345 3.5 Fr ST1 72-4364 ST1 72-4368 ST1 72-4372 5 Fr ST1 72-4338 ST1 72-4342 ST1 72-4346 5 Fr ST1 72-4365 ST1 72-4369 ST1 72-4373 7 Fr ST1 72-4339 ST1 72-4343 ST1 72-4347 7 Fr ST1 72-4366 ST1 72-4370 ST1 72-4374

*Note: Sold in non-sterile 100 ft. continuous roll.

Silastic is a registered trademark of Dow Corning Corporation. CBAS is a registered trademark of Carmeda AB.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 151 VASCULAR ACCESS PORTS

Large Vascular Access Ports

Porthold™ Non-Coring Needles

Solomon Large Vascular Access Ports Solomon PortHold™ Subcutaneous Access Ports

• For use with dogs, pigs, large primates and other Solomon has developed the PortHold™ to reduce the risk of large animals inadvertent needle dislodgement from implanted ports. The port

& SAMPLING features a titanium plate under the septum with holes that are DELIVERY Specifications slightly larger than the 22 gauge needle used to access it. The plate grips the needle and prevents it from becoming dislodged due to Port Model Titanium the normal pulls and tugs experienced during an animal study. Use Port Volume 0.65 ml only pencil-point needles to access these ports. Patent pending. Dimensions

Height 1.2 cm (0.5 in) Specifications Top Diameter 1.5 cm (0.6 in) Body & Plate Material Titanium Base Diameter 2.7 cm (1.1 in) Dead Volume 0.38 ml Weight (port body) 10.4 g Height 10.0 mm (0.395 in) Punctures with 22 ga 2,000 Huber Point Needle Weight 6.9 g Catheter Length 60 cm (24 in), with 2 retention beads Catheter Length 3.5 to 7 Fr Sterilization Sterilization EtO; CBAS® and PU are sterilizable Sterilization Sterilization EtO; CBAS® and PU are sterilizable by EtO only by EtO only

PortHold™ Subcutaneous Access Ports, pkg. of 1 Large Vascular Access Ports, pkg. of 1 Silastic® CBAS®-coated Silastic® CBAS®-coated Size, Fr Catheters PU Uncoated PU Size, Fr Catheters PU Uncoated PU Detachable Catheters Pre-Attached Catheters 3.5 Fr ST1 72-2839 ST1 72-2833 ST1 72-2836 3 Fr ST1 72-4300 ST1 72-4304 ST1 72-4308 5 Fr ST1 72-2840 ST1 72-2834 ST1 72-2837 3.5 Fr ST1 72-4301 ST1 72-4305 ST1 72-4309 7 Fr ST1 72-2841 ST1 72-2835 ST1 72-2838 5 Fr ST1 72-4302 ST1 72-4306 ST1 72-4310 7 Fr ST1 72-4303 ST1 72-4307 ST1 72-4311 Detachable Catheters PortHold™ Non-Coring Needle Sets 3 Fr ST1 72-4312 ST1 72-4316 ST1 72-4320 3.5 Fr ST1 72-4313 ST1 72-4317 ST1 72-4321 The tips of these needle sets are specially designed to access 5 Fr ST1 72-4314 ST1 72-4318 ST1 72-4322 Solomon’s PortHold™ Access Ports. The needle sets include PVC 7 Fr ST1 72-4315 ST1 72-4319 ST1 72-4323 tubing, a female Luer and a mini-clamp. The SOFTEE™ hub is designed to increase animal comfort and improve grip. They are supplied sterile in packages of 12. Use the ST1 72-2816 Huber Needle for direct flushing with a syringe, see page 153. NOTE: For Septum Needle for use with Vascular Access ports, see page 153. PortHold™ Non-Coring Needle Sets, pkg. of 12 Order # Product

9 ST1 72-2829 22 ga x ⁄ 16 in Needle, 6 in Tubing

9 ST1 72-2830 22 ga x ⁄ 16 in Needle, 12 in Tubing

5 ST1 72-2831 22 ga x ⁄8 in Needle, 6 in Tubing

5 ST1 72-2832 22 ga x ⁄8 in Needle, 12 in Tubing Silastic is a registered trademark of Dow Corning Corporation. CBAS is a registered trademark of Carmeda AB. PortHold is a trademark of Solomon Scientific.

152 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com HUBER NEEDLES & SETS

Solomon SOFTEE™ Huber Needles HUBER NEEDLES AND SETS Right-Angle Huber Huber needles have a non-coring tip for repeated access Needle Sets (SHNRA) with ports. All Hubers feature the shorter B-bevel for a better The SOFTEE™ Huber right angle fit in the port. infusion set is an innovation Huber needles with Luer attach to a syringe for manual intended to provide a softer injections into a port. The SOFTEE™ right angle huber sets are needle base for contact with for longer-term port access in large animals. They include an animal’s skin and to offer an ™ PVC tubing, a female Luer and a mini-clamp. The SOFTEE enhanced gripping surface for hub is designed to increase animal comfort and improve grip. ease of insertion and removal. The special “flexible delta” design They are supplied sterile in packages of 12. of the SOFTEE™ Huber base provides a compact improvement on the “wings” design commonly seen in butterfly IV needle sets. The flexible needle block material combined with the special knurling near the top of the flexible delta enhances the researcher’s grip during insertion and removal of the SOFTEE™ Huber. Huber Needle with Luer

Order # Product

1 ST1 72-2818 22 ga x ⁄2 in, 6 in Tubing, pkg. of 12

1 ST1 72-2819 22 ga x ⁄2 in, 12 in Tubing, pkg. of 12

1 ST1 72-2820 22 ga x ⁄2 in, 24 in Tubing, pkg. of 12

5

ST1 72-2821 22 ga x ⁄8 in, 6 in Tubing, pkg. of 12

5 ST1 72-2822 22 ga x ⁄8 in, 12 in Tubing, pkg. of 12

5 ST1 72-2823 22 ga x ⁄8 in, 24 in Tubing, pkg. of 12

3 Solomon Huber Needle with Luer (HN) ST1 72-2824 22 ga x ⁄4 in, 6 in Tubing, pkg. of 12 3 ST1 72-2825 22 ga x ⁄4 in, 12 in Tubing, pkg. of 12 DELIVERY & SAMPLING 3 The basic Huber needle features a female Luer for direct ST1 72-2826 22 ga x ⁄4 in, 24 in Tubing, pkg. of 12 attachment to a syringe. It has a B-bevel tip. They are available sterile in packs of 12. Instech Miniature Tubing Injection Port Order # Product ST1 72-2815 22 ga x 0.75 in long, pkg. of 12 Use this small injection port to ST1 72-2816 24 ga x 0.75 in long, pkg. of 12 terminate infusion tubing or catheters. Inject, flush or sample by piercing the septum in the port with a syringe fitted with an ST1 72-4071 needle or the ST1 72-4080 male connector with needlestick protection. The septum is good for over 200 sticks. The port measures 6 mm in diameter by 6 mm long and weighs 360 mg. Dead volume is only 8 µl. The 22 gauge tubing inlet is 4 mm long and makes a reliable friction fit with 3 French PU tubing catheters or 3 French PU or PE50 tubing. For laboratory animal use only. Instech Septum Needles

The special non-coring “pencil point” tip on these needles is Order # Product designed to pierce the septum of Instech’s Vascular Access ST1 72-2827 Miniature Tubing Injection Port, 22 ga x 4 mm, Harness™, Vascular Access Button™, Miniature Tubing Injection Ports sterile, pkg. of 12 and the PortHold™ (ST1 75-0278 only). The female Luer attaches ST1 72-4071 VAH™ Septum Needles, 22 ga x 0.5 in, sterile, directly to a syringe. Use these needles to inject lock solution flush, individually packaged bolus or withdraw blood samples. ST1 72-4080 Male VAH™ Connector with luer stub, 3 cm PU tubing, sterile

Order # Product ST1 72-4071 VAH™ septum needles, 22 ga x 0.4 in, sterile, individually packaged, pkg. of 12 ST1 72-4473 Pencil Point needle with luer, 22 ga x 0.4 in, 50 per sterile pack, pkg. of 50 ST1 75-0278 VAH™ septum needles, 24 ga x 0.75 in, sterile, individually packaged, pkg. of 12 Vascular Access Harness, VAH and Vascular Access Button are trademarks of Instech Laboratories, Inc. SOFTEE and PortHold are trademarks of Solomon Scientific.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 153 DRUG DELIVERY CAPSULES

Mini Gelatin Drug Delivery Capsules shown with Dosing Mini Gelatin Capsule Simple Delivery Syringe and Single Capsule Filling Funnel Filling Funnel Delivery of these capsules is simple and easy. The filled capsule is placed in the dosing syringe. The delivery tube of the dosing syringe is inserted into the animal’s esophagus. When in place, the syringe plunger is pressed and placement of the capsule is complete. Regardless of the location of the capsule in the esophagus, provided normal peristaltic action Mini Gelatin Drug Delivery Capsule occurs, the capsule will reach the stomach and then discharge its contents within 10 minutes. The capsules may also be used for • Two mini sizes are available and are the only capsules dosing rectally, vaginally, or subcutaneously. For first time users it small enough for use with rats is recommended that you practice with empty capsules. This allows both the researcher and the animal to acclimate to the procedure. • Ideal for encapsulating and dosing materials that are insoluble, form poor suspensions, are effected by These drug delivery capsules are clear and supplied in a package excepients, or are odorous and distasteful to the animal of 100. The dosing syringe and filler funnels must be purchased separately. Large size delivery capsules available, see page 155. & SAMPLING • Saves time and money by eliminating validation of DELIVERY suspension/solution homogeneity • Excellent alternative to gavage Specifications Fill Material Dry materials (powder, beadlets, crystals, paint • Release of dose within 10 minutes of reaching stomach flakes), pastes, non-aqueous liquids

• For use with: Capsule Capacity Holds 25 mg per capsule with density of 1 g/ml – Rats that are 200 grams and larger Capsule Disintegration Within 10 mins. of reaching stomach – Guinea pigs that are 300 grams and larger Time < 1 min. per animal • Oral delivery of dry materials (powder, beadlets, crystals, Dosing Time paint flakes), pastes, and non-aqueous liquids Acceptance > 98% successful dosing after minimal experience (3 to 4 placebo doses per rat) These are the only capsules on the market today that are small Capsule Dimensions: Size 9 Size 9el enough for dosing rats. They are also suitable for guinea pigs. Capacity 0.025 ml 0.08 ml They are ideal for the delivery of dry materials (powder, beadlets, Fill Weight 25 mg 80 mg crystals, paint flakes, etc.), pastes, and non-aqueous liquids. They External Diameter 2.65 mm 2.65 mm can also be used to encapsulate and dose materials that are Locked Length 8.6 mm 23.2 mm insoluble, form poor suspensions, are effected by excepients, or Dosing Syringe: are odorous and distasteful to the animal. The capsules are made Material Stainless steel, stiff from hard gelatin. It is the same process and substance used for OD End Cup 3.5 mm (0.13 in) capsules manufactured for human use. They meet all FDA standards Length 125 mm (4.9 in) from hub to tip as well as US, European, and Japanese Pharmacopeia standards. Additionally, with an enteric coating they are suitable for lower GI drug delivery in guinea pigs. Order # Product ST1 72-1690 Drug Delivery Capsule, Size 9 Easy-to-Fill ST1 72-4160 Drug Delivery Capsule, Size 9el The small size capsules are filled with the desired substance using ST1 72-1691 Dosing Syringe for Size 9 Capsules the convenient filling funnel. Simply place the capsule body into ST1 72-4161 Dosing Syringe for Size 9el Capsules the holder, place the funnel over the holder and fill. They can ST1 72-1692 Filling Funnel for Size 9 Capsules be filled either with a premeasured dose or by weight. To fill by ST1 72-4162 Filling Funnel for Size 9el Capsules weight, simply place the whole setup on a precision balance prior ST1 72-4158 Complete Kit with Size 9 Capsules* to filling. Tare it and then fill the capsule. When the desired amount ST1 72-4159 Complete Kit with Size 9el Capsules* of the substance is in the capsule, remove the funnel and place the Multiple Capsule Filler for Size 9, pkg. of 1 capsule cap onto the body. You are now ready to administer the ST1 72-1693 capsule to the animal. A multiple capsule filler is available which will ST1 72-4163 Multiple Capsule Filler for Size 9el, pkg. of 1 accommodate 40 capsules simultaneously. *Note: Dosing Kit includes: 1 dosing syringe, 1 filling funnel and stand, 1 tamper, 100 capsules and an instructional video

Reference: 1. “A Simple Method for Administration of Drugs in Solid Form to Fully Conscious Rats,“ Lax, E.R., et al, Laboratory Animals (1983) 187, 50-54

154 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com DRUG DELIVERY CAPSULES

Small Animal Drug Delivery Capsules These drug delivery capsules are similar to the Mini Drug Delivery ST1 72-1694 – ST1 72-1701 Capsule on page 154, just larger in size. They are ideal for the delivery of dry materials (powder, beadlets, crystals, paint flakes, etc.), pastes, and non-aqueous liquids. They can also be used to encapsulate and dose materials that are insoluble, form pore suspensions, are effected by excepients, or are odorous and distasteful to the animal. The capsules are made from hard gelatin. It is the same process and substance used for capsules manufactured for human use. They meet all FDA standards as well as US, European, and Japanese Pharmacopeia standards. These gelatin capsules are designed to dissolve in vivo at 37°C within 15 minutes. Gelatin is physiologically inert so it will not react with most test materials or effect their bioavailability. When using capsules for dosing animals, you can be sure that the exact and complete dose has been administered. And unlike gavage, when you use capsules you don’t have the problem of solution validation or the possibility of lung aspiration. Capsules are convenient and easy to handle and in most cases it takes only one person to dose Small Animal Gelatin Drug Delivery Capsules an animal. • 8 sizes available for use with kittens to dogs These drug delivery capsules are clear and available in 8 sizes. • Ideal for encapsulating materials that are insoluble, form They are supplied in a package of 100. Larger sizes are available by poor suspensions, are effected by excepients, or are special order. Please call for details. odorous and distasteful The following capsule size chart and table of specifications will • Saves time and money by eliminating validation of aid in determining which size capsule is appropriate for the suspension/solution homogeneity specific animal being dosed and the amount of test material to be DELIVERY

• An excellent alternative to gavage administered. & SAMPLING • In compliance with US, European and Japanese A filling funnel is available separately for each size capsule. They are Pharmacopeias supplied individually and make filling the capsules simple and fast. • Fillable with almost any dry materials, pastes, and non-aqueous liquids • Machine fillable

Small Animal Gelatin Drug Delivery Capsules

Capsule Size 5 4 3 2 1 0 00 000 Species Dog, Cat, Rabbit, Dog, Cat, Rabbit, Dog, Cat, Rabbit, Dog, Rabbit, Dog, Rabbit, Dog, CatRabbit, Dog, Rabbit, Dog, Cat Fish, Bird Fish, Bird Fish Fish Fish Volume 0.13 ml 0.21 ml 0.30 ml 0.37 ml 0.50 ml 0.68 ml 0.95 ml 1.37 ml Fill Weight Range 60 -130 mg 95 - 210 mg 135 - 300 mg 165- 370 mg 225 - 500 mg 305 - 680 mg 430 - 950 mg 615 - 1370 mg External Diameter: Cap 4.83 mm 5.31 mm 5.82 mm 6.35 mm 6.91 mm 7.65 mm 8.53 mm 9.91 mm Body 4.64 mm 5.05 mm 5.56 mm 6.07 mm 6.63 mm 7.34 mm 8.18 mm 9.55 mm Locked Length 11.0 mm 13.9 mm 15.5 mm 17.5 mm 19.0 mm 21.2 mm 23.3 mm 26.1 mm Drug Delivery Capsule ST1 72-1694 ST1 72-1695 ST1 72-1696 ST1 72-1697 ST1 72-1698 ST1 72-1699 ST1 72-1700 ST1 72-1701 Filling Funnel ST1 72-4150 ST1 72-4151 ST1 72-4152 - ST1 72-4154 ST1 72-4155 ST1 72-4156 ST1 72-4157 Dosing Syringe ST1 72-7475 ST1 72-7474 ST1 72-9170 ST1 72-7477 ST1 72-7476 ST1 72-9171 ST1 72-9172 ST1 72-9173

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 155 DELIVERY & SAMPLING SPOTLIGHT

Harvard Apparatus Spotlight On: Glucose Clamp

Cyclical and Alternating Infusions of Glucose in Wistar rats. Hyperglycemia was induced with glucose infusions and Intralipid in Rats Inhibit Insulin Gene and hyperlipidemia was induced with Intralipid infusions. Changes Expression and Pdx-1 Binding Islets to insulin secretion in vivo and in vitro isolated islet cells, changes to insulin mRNA levels, Pdx-1 binding to the insulin promoter and Pdx-1 Equipment Featured: and MafA expression, and changes to pancreatic β-cell mass were ST1 61-0001 Single Channel Stainless Steel Swivel, page 112 tracked. Animals were infused with glucose, Intralipid, or glucose + Inralipid. This study found that with an in vivo cycling and alternating ST1 55-3333 Harvard Apparatus Pump 33 infusions of glucose, Intralipi, and Intralipid plus glucose reduced ST1 61-0023 6 in Counter-Balanced Lever Arm, page 120 mRNA levels and insulin content without changing β-cell mass or insulin secretion. Pdx-1 was shown to be inhibited from binding to ST1 62-0058 Rat Animal Jacket, Medium, page 129 the endogenous insulin promoter. These results confirm the existing Summary: results from in vitro studies. MafA expression was not affected, unlike what is found in vitro. The in vivo model was very successful Research into β-cell failure has typically looked at insulin resistance in vitro, not as much is known about the role of metabolic alterations in confirming the in vitro studies findings. Fatty acid inhibition of insulin gene expression may be an early functional defect and may in β-cell dysfunction in vivo. Prolonged exposure of isolated islets of Langerhorns to elevated levels of fatty acids in the presence contribute to β-cell failure. Further studies are needed. of glucose leads to impairment of insulin gene expression. This & SAMPLING

DELIVERY impairment involves a transcriptional mechanism involving nuclear Hagman, D.K., et. al. (2008), Diabetes, Vol. 57:424-431. exclusion of pancreas-duodenum homeobox-1 (Pdx-1) and loss of MafA expression. Hagman, et. al. wanted a more physiologically relevant study to better represent the mixture of saturated and Scan this QR code

unsaturated fatty acids present in circulation and the cyclic to view the article: variation of fatty acid levels that occur in vivo. Hyperglycemia and hyperlipidemia were induced cyclically in 4 hr infusions over 72 hr

156 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com ANESTHESIA

Harvard Apparatus has a proven track record of providing and supporting top quality anesthesia equipment. Anesthesia is a vital part of surgery and we offer a wide array of products for your surgical needs. We are now pleased to offer several complete systems. These systems are based on the most widely used configurations we see in our customers' laboratories. Our preconfigured packages ensure you have all of the parts, regulators, tubing and connectors you need to get started. If you do not see a combination that is suitable for you, a unique system can be created for you. Please see pages 164-181 for custom configurations or feel free to contact us at [email protected]

PRODUCT PAGE

Complete Table Top Anesthesia Systems...... 158-159 Complete Mobile Anesthesia Systems...... 160-161 Complete Fluovac Systems...... 162-163 Complete Trolley Anesthesia Systems...... 164 Regulators, Hoses and Flowmeters...... 165-166 Anesthesia Machines...... 167-170 CDS9000...... 167 Table-Top...... 168 Small and Large Anesthesia Bracket...... 168 Mobile Post...... 169 Vaporstick...... 169 Modular Trolley...... 170 Multiple Animal...... 170 Vaporizers...... 171 Vaporizer Accessories...... 171 Gas Delivery Options...... 172-175 Anesthesia Circuit Sets...... 172 Anesthesia Masks and Nose Cones...... 173 Anesthetizing Chambers/Induction Boxes...... 174-175 Gas Delivery Management...... 176 Scavanging and Evacuation...... 177-179

Fluovac and Accessories...... 179-181 ANESTHESIA Respiratory Valves...... 182-183 Respiratory Accessories...... 184 ANESTHESIA EQUIPMENT

ANESTHESIA SYSTEMS Harvard Apparatus has a long history of carrying and supporting top quality anesthesia equipment. We have for the first time taken our knowledge and created easy to order systems. We have based these systems on what our customers are using in their laboratories. Our preconfigured packages ensure you have all of the parts, regulators, tubing and connectors you need to get up and get started right away. If you do not see a combination that is suitable for you, a unique system can be created for you. Please see pages 164 for custom configurations or feel free to contact us at [email protected].

Table-Top Systems: Suitable for Small Rodents ANESTHESIA

Single Animal Anesthesia System Harvard Apparatus Single Animal Isoflurane System • Our most popular set up • Suitable for mice, rats and other small • Ideal flowmeter range for rodents animals under 10 lbs • Small footprint • Features a new Funnel-Fill Isoflurane Vaporizer with • Suitable for mice, rats and other small animals under 10 lbs 3 year warranty • Brand new Funnel-Fill Isoflurane Vaporizer with • Can be expanded for animals over 10 lbs 3 year warranty • Passive scavenging system • Passive scavenging system

Item # Product Item # Product ST1 72-6419 Single Animal Anesthesia System, Table-Top1 ST1 72-6467 Harvard Apparatus Single Animal Isoflurane System1 System Includes: System Includes: ST1 72-3100 H-Tank Regulator ST1 72-3100 H-Tank Regulator ST1 72-3115 Oxygen Hose, 3 m (10 ft) ST1 34-1375 Oxygen Hose, 4 m (13.1 ft) ST1 72-3011 Table-Top Anesthesia Machine 0.2-4 LPM Flowmeter, ST1 34-1352 Small Bracket 1-2 gasses Circuit Set and End Caps ST1 34-1420 Flowmeter 0.2-2 LPM ST1 34-1040SV Isoflurane Funnel-Fill Vaporizer ST1 34-1040 Isoflurane Funnel-Fill Vaporizer ST1 34-0415 Fluosorber Canisters ST1 72-3043 Male End Cap ST1 34-0400 Halovet Connector ST1 72-3044 Female End Cap 3 ST1 72-1024 ⁄ 16 in ID tubing ST1 72-3026 Rodent Circuit Set ST1 72-2889 Connector 22 mm-6 mm, pkg. of 10 ST1 34-0415 Fluosorber Canisters ST1 72-3054 Anti-Spill Adapter ST1 34-0400 Halovet Connector

3 ST1 72-1024 ⁄ 16 in ID tubing ST1 72-2889 Connector 22 mm-6 mm, pkg. of 10 ST1 72-3054 Anti-Spill Adapter

1Note: International versions are available and do not include regulators. Please use ST1 72-6419INT and ST1 72-6467INT.

158 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com ANESTHESIA EQUIPMENT

Table-Top Systems: Systems with an Induction Box

Single Animal Anesthesia System Harvard Apparatus Single Animal Isoflurane with Small Induction Box System with Small Induction Box

• Our most popular set up configured • Ideal flowmeter range for rodents with a small induction box • Includes Small Induction Box for mice and rats • Suitable for mice, rats and other small animals • Small footprint under 10 lbs • Brand new Funnel-Fill Isoflurane Vaporizer • Features a new Funnel-Fill Isoflurane Vaporizer with 3 year warranty with 3 year warranty • Passive scavenging system • Passive scavenging system • Can be expanded for animals over 10 lbs Item # Product ST1 72-6468 Harvard Apparatus Single Animal Isoflurane Item # Product System with Small Induction Box1 ST1 72-6420 Single Animal Anesthesia System with Small Induction Box1 System Includes: ANESTHESIA System Includes: ST1 72-3100 H-Tank Regulator ST1 72-3100 H-Tank Regulator ST1 34-1375 4 m Oxygen Hose ST1 72-3115 Oxygen Hose, 3 m (10 ft) ST1 34-1352 Small Bracket 1-2 gasses ST1 72-3011 Table-Top Anesthesia Machine 0.2-4 LPM Flowmeter, ST1 34-1420 Flowmeter 0.2-2 LPM Circuit Set, and End Caps ST1 34-1040 Isoflurane Funnel Fill Vaporizer ST1 34-1040SV Isoflurane Funnel-Fill Vaporizer ST1 72-3043 Male End Cap ST1 34-0415 Fluosorber Canisters ST1 72-3044 Female End Cap ST1 34-0400 Halovet Connector ST1 72-3026 Rodent Circuit Set 3 ST1 72-1024 ⁄ 16" ID tubing ST1 34-0415 Fluosorber Canisters ST1 72-2889 Connector 22 mm-6 mm, pkg. of 10 ST1 34-0400 Halovet Connector

ST1 72-3054 Anti-Spill Adapter 3 ST1 72-1024 ⁄ 16" ID tubing ST1 60-5242 Manifold for Two Devices ST1 72-2889 Connector 22 mm-6 mm, pkg. of 10 ST1 50-0108 Small Induction Box, H x W x D, ST1 72-3054 Anti-Spill Adapter 10.7 x 25.7 x 11 cm (4 x 10 x 4.5 in) ST1 60-5242 Manifold for Two Devices ST1 50-0108 Small Induction Box, H x W x D, 10.7 x 25.7 x 11 cm (4 x 10 x 4.5 in)

1Note: International versions are available and do not include regulators. Please use ST1 72-6420INT and ST1 72-3100INT.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 159 ANESTHESIA EQUIPMENT

Mobile Systems: Suitable for Small Rodents ANESTHESIA

Mobile Single Animal System*

• Suitable for mice, rats and other small animals under 10 lbs • Ideal flowmeter range for rodents • Features a new Funnel-Fill Isoflurane Vaporizer Mobile Single Animal Anesthesia System* with 3 year warranty • Passive scavenging system • Suitable for mice, rats and other small animals under 10 lbs Item # Product • Features a new Funnel-Fill Isoflurane Vaporizer Harvard Apparatus Mobile Single Animal System for Isoflurane with 3 year warranty ST1 72-6469 System Includes: • Can be expanded for animals over 10 lbs ST1 34-1060 O2 Pin Index Regulator E-Cylinder • Passive scavenging system ST1 34-1384 Mobile Anesthesia Post ST1 34-1352 Small Bracket 1-2 gasses Item # Product ST1 34-1420 Flowmeter 0.2-2 LPM ST1 72-6421 Single Animal Mobile Anesthesia System ST1 34-1040 Isoflurane Funnel Fill Vaporizer System Includes: ST1 72-3043 Male End Cap

ST1 72-3018 Single O2 E-Cylinder Regulator & Yokes ST1 72-3044 Female End Cap ST1 72-3007 Vaporstick ST1 72-3026 Rodent Circuit Set ST1 72-3026 Rodent Circuit Set ST1 72-1294 F/Air Canisters, case of 8 ST1 34-1040SV Isoflurane Funnel-Fill Vaporizer ST1 60-5251 Connector for F/Air Canister

3 ST1 72-1294 F/Air Canisters, case of 8 ST1 72-1024 ⁄ 16" ID tubing ST1 60-5251 Connector for F/Air Canister ST1 72-2889 Connector 22 mm-6 mm, pkg. of 10

3 ST1 72-1024 ⁄ 16" ID tubing ST1 72-3054 Anti-Spill Adapter ST1 72-2889 Connector 22 mm-6 mm, pkg. of 10 *Note: Mayo Tray not included. ST1 72-3054 Anti-Spill Adapter

160 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com ANESTHESIA EQUIPMENT

Mobile Systems: Systems with an Induction Box

Mobile Anesthesia System with Small Induction Box

Mobile Single Animal Anesthesia System • Suitable for mice, rats and other small animals ANESTHESIA with Small Induction Box under 10 lbs • Ideal flowmeter range for rodents • Suitable for mice, rats and other small animals • Includes small Induction box for mice and rats under 10 lbs • Features a new Funnel-Fill Isoflurane Vaporizer • Includes Small Induction Box with 3 year warranty • Features a new Funnel-Fill Isoflurane Vaporizer • Passive scavenging system with 3 year warranty • Can be expanded for animals over 10 lbs Item # Product • Passive scavenging system ST1 72-6470 Harvard Apparatus Mobile Anesthesia System with Small Induction Box Item # Product System Includes:

ST1 72-6422 Mobile Single Animal Isoflurane System ST1 34-1060 O2 Pin Index Regulator E-Cylinder with Small Induction Box ST1 34-1384 Mobile Anesthesia Post System Includes: ST1 34-1352 Small Bracket 1-2 gasses

ST1 72-3018 Single O2 E-Cylinder Regulator & Yokes ST1 34-1420 Flowmeter 0.2-2 LPM ST1 72-3007 Vaporstick ST1 34-1040 Isoflurane Funnel Fill Vaporizer ST1 72-3026 Rodent Circuit Set ST1 72-3043 Male End Cap ST1 34-1040SV Isoflurane Funnel-Fill Vaporizer ST1 72-3044 Female End Cap ST1 60-5242 Manifold for Two Devices ST1 72-3026 Rodent Circuit Set ST1 50-0108 Small Induction Box ST1 60-5042 Manifold for Two Devices ST1 72-3017 Mayo Tray ST1 50-0108 Small Induction Box ST1 72-1294 F/Air Canisters, case of 8 ST1 72-3017 Mayo Tray ST1 60-5251 Connector for F/Air Canister ST1 72-1294 F/Air Canisters, case of 8 3 ST1 72-1024 ⁄ 16" ID tubing ST1 60-5251 Connector for F/Air Canister ST1 72-2889 Connector 22 mm-6 mm, pkg. of 10 ST1 72-2889 Connector 22 mm-6 mm, pkg. of 10 ST1 72-3054 Anti-Spill Adapter ST1 72-3054 Anti-Spill Adapter

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 161 FLUOVAC SYSTEMS

FLUOVAC SYSTEMS The Harvard Apparatus Fluovac System is an active delivery and scavengiing device that substantially reduces the risk of exposure to anesthetic vapors from your surgical area. The Fluovac is self contained remedying the need for ducting or special ventilation that is traditional with active scavenging. The Fluovac includes specially designed masks that deliver and scavenge the halogenated gas that provide improved access to the animal during surgery. ANESTHESIA

Two Animal Fluovac System for Mice Two Animal Fluovac System for Rats

• Complete with Mouse Size 0.5 Double-Arm Fluovac • Complete with Size 1 Double-Arm Fluovac Mask set Mask set • Includes Small Anesthetic Bracket system • Includes Small Anesthetic Bracket system for small rodents for small rodents • New Funnel Fill Isoflurane Vaporizer with 3 year warranty • New Funnel Fill Isoflurane Vaporizer with 3 year warranty

Item # Product Item # Product ST1 72-6471 Two Animal Fluovac System for Mice, 115 VAC, 60 Hz1 ST1 72-6472 Two Animal Fluovac System for Rats, 115 VAC, 60 Hz1 System Includes: System Includes: ST1 72-3100 H-Tank Regulator ST1 72-3100 H-Tank Regulator ST1 34-1375 Oxygen Hose, 4 m (13.1 ft) ST1 34-1375 Oxygen Hose, 4 m (13.1 ft) ST1 34-1352 Small Bracket 1-2 gasses ST1 34-1352 Small Bracket 1-2 gasses ST1 34-1420 Flowmeter 0.2-2 LPM ST1 34-1420 Flowmeter 0.2-2 LPM ST1 34-1040 Isoflurane Funnel Fill Vaporizer ST1 34-1040 Isoflurane Funnel Fill Vaporizer ST1 72-3043 Male End Cap ST1 72-3043 Male End Cap ST1 72-3044 Female End Cap ST1 72-3044 Female End Cap ST1 34-1440 Fluovac Base Unit, 115 VAC, 60 Hz ST1 34-0388 Fluovac System, 115 VAC, 60 Hz ST1 34-0432 Y-Piece, pkg. of 1 ST1 34-0415 Fluosorber Canisters ST1 34-0433 Tubing Clamps, pkg. of 1 ST1 34-0400 Halovet Connector

3 ST1 34-0825 Inner Fluovac Tubing, pkg. of 1 ST1 72-1024 ⁄ 16" ID tubing ST1 34-1421 Fluovac Mask Size 0.5 Double Arm ST1 72-3054 Anti-Spill Adapter ST1 34-0415 Fluosorber Canisters ST1 34-0400 Halovet Connector

3 ST1 72-1024 ⁄ 16" ID tubing ST1 72-3054 Anti-Spill Adapter

1Note: For 230 VAC, 50 Hz Fluovac, please use ST1 72-6471INT and ST1 72-6472INT. International versions do not include regulators.

162 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com FLUOVAC SYSTEMS

Fluovac Systems: Systems with an Induction Box

Two Animal Fluovac System for Mice Two Animal Fluovac System for Small Animals with Small Induction Box with Large Induction Box

• Complete with Size 0.5 Double-Arm Fluovac Mask set • Complete with Size 1 Double-Arm Fluovac Mask set • Small Induction Box, 134 x 128 x 170 mm (5.3 x 5 x 6.7 in) • Large Induction Box, 200 x 200 x 305 mm • Includes Small Anesthetic Bracket System (7.9 x 17.9 x 12 in) for small rodents • Includes Small Anesthetic Bracket system • New Funnel Fill Isoflurane Vaporizer with 3 year warranty for small rodents • New Funnel Fill Isoflurane Vaporizer with 3 year warranty

Item # Product Item # Product ST1 72-6473 Two Animal Fluovac System for Mice ST1 72-6474 Two Animal Fluovac System -Small Animals with Small Induction Box, 115 VAC, 60 Hz1 with Large Induction Box, 115 VAC, 60 Hz1

System Includes: System Includes: ANESTHESIA ST1 72-3100 H-Tank Regulator ST1 72-3100 H-Tank Regulator ST1 34-1375 Oxygen Hose, 4 m (13.1 ft) ST1 34-1375 Oxygen Hose, 4 m (13.1 ft) ST1 34-1352 Small Bracket 1-2 gasses ST1 34-1352 Small Bracket 1-2 gasses ST1 34-1420 Flowmeter 0.2-2 LPM ST1 34-1420 Flowmeter 0.2-2 LPM ST1 34-1040 Isoflurane Funnel Fill Vaporizer ST1 34-1040 Isoflurane Funnel Fill Vaporizer ST1 34-1067 Outlet Tube Mount ST1 72-3043 Male End Cap ST1 72-3044 Female End Cap ST1 72-3044 Female End Cap ST1 34-1440 Fluovac Base Unit, 115 VAC, 60 Hz ST1 34-0388 Fluovac System, 115 VAC, 60 Hz ST1 34-0432 Y-Piece, pkg. of 1 ST1 34-0415 Fluosorber Canisters ST1 34-0433 Tubing Clamps, pkg. of 1 ST1 34-0458 Fluovac Anesthetizing Chamber w/Gas Scavenging System ST1 34-0825 Inner Fluovac Tubing, pkg. of 1 ST1 34-0393 Gas Flow Director

3 ST1 34-1421 Fluovac Mask Size 0.5 Double Arm ST1 72-1024 ⁄ 16" ID Tubing* ST1 34-0415 Fluosorber Canisters ST1 72-3054 Anti-Spill Adapter ST1 34-0461 Fluovac Anesthetizing Chamber with Gas Scavenging Small ST1 34-0393 Gas Flow Director

3 ST1 72-1024 ⁄ 16" ID Tubing* ST1 72-3054 Anti-Spill Adapter

1Note: For 230 VAC Fluovac, 50 Hz, please use ST1 72-6471INT and ST1 72-6472INT. International versions do not include regulators.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 163 TROLLEY ANESTHESIA SYSTEMS

Harvard Apparatus has developed an extensive range of off the shelf anesthesia trolley systems suitable for a wide range of small animal surgical applications. • Complete pre-configured systems • Anti-static castors • Stainless steel shelving and cart • Pin Index ( E-Tank) regulators • Fully tested system, supplied nearly fully assembled

Specifications Dimension (H x W x D) 1415 x 480 x 720 mm (55.7 x 18.9 x 28.3 in) Top Shelf (D x W) 480 x 400 mm (18.9 x 15.8 in)

Complete Pre-Configured Systems

Please refer to the simple selection table below to select your appropriate trolley system for your requirements. All systems are supplied complete, and include all regulators, flowmeter(s), vaporizer, tube mounts and are supplied nearly assembled and tested. ANESTHESIA

Complete Pre-Configured Systems Isoflurane Key Fill Pour Fill Oxygen N2O Vaporizer Vaporizer Vaporizer Low O2 Alarm N2O Cut Off ST1 34-1048 • – • – • – – ST1 34-1050 • • • – • • • ST1 34-1117 • – • • – – – ST1 34-1119 • • • • – • •

CUSTOM CONFIGURATIONS For a full system you will need: Can’t find a set-up that is right for you? Need replacement • Regulator • Delivery System, i.e. parts? The following pages will allow you to choose what is right nosecone, ventilator, •  Anesthesia Machine and/or induction box for your experiment. As well as provide answers to your gas that includes a Bracket delivery needs outside of your anesthesia system. and Flowmeter • Scavenging, active or passive • Vaporizer

164 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com REGULATORS, HOSES & FLOWMETERS

ST1 72-3100

O2 Regulator for H-Cylinder

ST1 72-3018 ST1 72-3104 Single O E-Cylinder Regulator 2 O2 Regulator for H-Cylinder & Double Tank Holder with 0 to 15 LPM Flowmeter

Regulators, Hoses, and Flowmeters

All of these products are based on the Diameter Index Safety System (DISS), developed to increase hospital safety in the United States. Regulators are typically specific for country, the type ST1 72-3020 of gas and tank size. E-Tanks and H-Tanks are two of the most Dual E-Cylinder O Tank 2 common sizes in the United States. All regulators terminate in a Yokes Holder and Regulator gas specific connection. The E-tank or Pin-Index regulators are not country specific, however these use DISS fittings as their mating ANESTHESIA connection.1

Order # Product

ST1 72-3099 O2 Regulator for E-Cylinder (Includes 2 ft O� Hose)

ST1 72-3100 O2 Regulator for H-Cylinder (O� Hose sold separately)

ST1 72-3103 O2 Regulator for E-Cylinder with 0 to 15 LPM Flowmeter

ST1 72-3104 O2 Regulator for H-Cylinder with 0 to 15 LPM Flowmeter

ST1 72-3018 Single O2 E-Cylinder Regulator & Double Tank Holder

ST1 72-3020 Dual E-Cylinder O2 Tank Yokes Holder and Regulator (should be ordered with ST1 72-2216) ST1 72-2216 Dual E-Cylinder Stabilizer (should be ordered with ST1 72-3020) ST1 72-7458 O� Regulator for H-Cylinder with 0 to 3 LPM Flowmeter ST1 72-2216 ST1 72-3112 0 to 3 LPM O Flowmeter2 E-Cylinder Stabilizer 2 2 ST1 72-3113 0 to 5 LPM O2 Flowmeter 2 ST1 72-3114 0 to 15 LPM O2 Flowmeter 3 ST1 72-3115 O2 Hose 10 ft 3 ST1 72-3116 O2 Hose 15 ft 3 ST1 72-3117 O2 Hose 20 ft 3 ST1 72-3118 N2O Hose 10 ft 3 ST1 72-3119 N2O Hose 15 ft 3 ST1 72-3120 N2O Hose 20 ft

ST1 72-5810 DISS Female Hose Barb—O2

ST1 72-5811 DISS Female Hose Barb—N2O 1 Anesthesia machines come complete with flowmeters, please see pages 167-170. 2 Flowmeter with Female DISS inlet and Male DISS outlet 3 Connectors on both ends are Female DISS

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 165 REGULATORS, HOSES & FLOWMETERS

ST1 34-1392

Regulators, Hoses, and Flowmeters

These products are supplied by Harvard Apparatus LTD primarily for customers in the UK. Where indicated they use DISS fittings. Choose the appropriate regulator for your compressed gas, hose and flowmeter to complete your system. Flowmeters include tube mounts. When ordering flowmeters, please specify in which country they will be used. For anesthesia bracket flowmeters please see ST1 34-1060 page 168.

Order # Product ST1 34-1059 Nitrous Oxide Pin Index Regulator ST1 34-1060 Oxygen Pin Index Regulator, Bull Nose ST1 34-1257 Air Pin Index Regulator

ST1 34-1137 CO2 Pin Index Regulator ST1 34-1392 Oxygen Threaded Regulator ST1 34-1395 Nitrous Threaded Regulator ANESTHESIA ST1 34-1393 Air Threaded Regulator

ST1 34-1394 CO2 Threaded Regulator ST1 34-0443 Regulator Tube Mounts, for any F-Cylinder Regulator

ST1 34-1410 O2 Flowmeter 0.4-4 LPM, Short Series

ST1 34-1420 O2 Flowmeter 0.2-2 LPM, Short Series

ST1 34-0403 O2 Flowmeter 0.2-15 LPM, Long Series

ST1 34-0405 O2 Flowmeter 0-10 LPM, Long Series

ST1 34-0406 CO2 Flowmeter 0-12 LPM, Long Series

ST1 34-0404 N2O Flowmeter 0.1-12 LPM, Long Series ST1 34-1410 ST1 34-0407 Flowmeter Bench Stand, suitable for Long and Short Series

ST1 34-1353 O2 Hose 2 m (6.6 ft)

ST1 34-1354 O2 Hose 4 m (13.1 ft)

ST1 34-1355 O2 Hose 6 m (19.7 ft)

ST1 34-1356 N2O Hose 2 m (6.6 ft)

ST1 34-1357 N2O Hose 4 m (13.1 ft) ST1 34-1420 ST1 34-1358 N2O Hose 6 m (19.7 ft) ST1 34-1359 Medical Grade Air Hose 2 m (6.6 ft) ST1 34-1360 Medical Grade Air Hose 4 m (13.1 ft) ST1 34-1361 Medical Grade Air Hose 6 m (19.7 ft)

ST1 34-1365 Piped O2 Hose to Flowmeter 2 m (6.6 ft)

ST1 34-1366 Piped O2 Hose to Flowmeter 4 m (13.1 ft)

ST1 34-1367 Piped O2 Hose to Flowmeter 6 m (19.7 ft)

ST1 34-1368 Piped N2O Hose to Flowmeter 2 m (6.6 ft)

ST1 34-1369 Piped N2O Hose to Flowmeter 4 m (13.1 ft)

ST1 34-1370 Piped N2O Hose to Flowmeter 6 m (19.7 ft) ST1 34-1371 Piped Air Hose to Flowmeter 2 m (6.6 ft) ST1 34-1372 Piped Air Hose to Flowmeter 4 m (13.1 ft) ST1 34-1373 Piped Air Hose to Flowmeter 6 m (19.7 ft)

ST1 34-1374 O2 Hose DISS Fittings to Flowmeter 2 m (6.6 ft)

ST1 34-1375 O2 Hose DISS Fittings to Flowmeter 4 m (13.1 ft)

ST1 34-1376 O2 Hose DISS Fittings to Flowmeter 6 m (19.7 ft)

166 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com ANESTHESIA MACHINES

Specifications Performance Characteristics: Absorber 900 cc Canister

Pop-off Valve 19 mm, relieves at 2 cmH2O Inhalation/ Tapered, 22 mm Exhalation Valves Flowmeter: Single 0.2-4 LPM Dual 0-1000ml; 0.2-4 LPM Flush Valve 10-15 LPM

Pressure 0-60 cmH2O, 0-30 cmH2O Vacuum Manometer Gas Inlets DISS male for all gasses Vaporizer Tapered, 23 mm Connection Environmental: Operating 15°C to 32°C Temperature Storage -1°C to +48°C Temperature Dimensions & Weight: Pole Mount 135 x 66 x 66 cm (53.25 x 26 x 26 in); (H x W x D) 10.4 kg (23 lbs) Table-Top 36.8 x 36.2 x 26.7 cm (14.5 x 14.25 x 10.5 in); (H x W x D) 6.8 kg (15 lbs) Calibration Daily pressure test recommended

Order # Product

ST1 72-7992 CDS9000 Pole Mount Anesthesia Machine with Single O2 Flowmeter 0.2-4 LPM

ST1 72-7993 CDS9000 Pole Mount Anesthesia Machine with Dual O2 Flowmeter 0-1000 ml; 0.2-4 LPM

ST1 72-7994 CDS9000 Pole Mount Anesthesia Machine with N2O/O2 ANESTHESIA Flowmeter 0.2-4 LPM

CDS9000 Small Anesthesia Machine ST1 72-6081 CDS9000 Table-Top Anesthesia Machine with Single O2 Flowmeter 0.2-4 LPM

CDS9000 is a versatile machine suitable for small and large animal ST1 72-6082 CDS9000 Table-Top Anesthesia Machine with Dual O2 anesthesia (rebreathing and non-rebreathing). It can be configured Flowmeters 0-1000ml/min; 0.2-4 LPM as a table-top or mobile system. ST1 72-6083 CDS9000 Table-Top Anesthesia Machine with N2O/O2 Flowmeter 0.2-4 LPM • Rebreathing (>10 lbs) and non-rebreathing (<10 lbs) Optional Conversion Kits & Brackets: machine ST1 72-6073 Table-Top Kit • Universal anodized aluminum block with built in ST1 72-6074 Wall Mount Kit inhalation/exhalation valves ST1 72-6075 Pole-Mount Kit • Powder coated for quick and easy cleaning ST1 72-6076 Monitor Bracket • Pop-off valve designed to interface with active waste system for maintaining a passively full breathing bag • Quick & easy change for absorber canister • Adaptable to all vaporizer styles • Optional monitor bracket • Flexibility of design allowing for Table-Top or Mobile set-up • All units are supplied complete with F-circuit with two liter bag, Modified Jackson Rees with ½ liter bag, Sodasorb® CO� Absorbent refill bag (2.2 lbs.), pop-off occlusion valve, end-caps and operation manual • Vaporizer sold separately • Reliable, easy to service and maintain, plus a 5-year warranty

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 167 ANESTHESIA MACHINES

Create Your Own Anesthetic Bracket Unit

• Small, non-rebreathing table-top system Basic Table-Top Anesthesia Machine • Flexible design allows user to define options • Can be added to Mobile Post System (see page 169) ANESTHESIA • Our most popular anesthesia machine • Non-rebreathing machine • Vaporizer not included (see page 171) • 20.3 x 20.3 x 33 cm (8 x 8 x 13 in), L x W x H • Complete anesthesia machine will include bracket, 1-2 flowmeter(s), inlet and outlet mount. • Powder coated for quick and easy cleaning • Supplied with, Rodent Circuit Set, Modified Jackson Rees 1 Base Unit Option #1: Large Bracket with ⁄2 liter bag, end-caps and operation manual 48.5 x 45.0 x 17.0 cm (19.1 x 17.7 x 6.7 in), H x W x D • Can be upgraded to rebreathing system with free standing CO2 system Order # Product • Adaptable to all vaporizer styles, vaporizer not included, ST1 34-1405 Large Bracket System for 1-2 gasses see page 171 ST1 34-0403 O2 Veterinary Flowmeter 0.2-15 LPM

ST1 34-0404 N2O Veterinary Flowmeter 0.1-12 LPM Order # Product ST1 34-1126 Air Veterinary Flowmeter, 0-15 LPM ST1 72-3011 Table Top Research System with 0.2-4 LPM O Flowmeter 2 ST1 34-1138 CO2 Veterinary Flowmeter, 0-12 LPM ST1 72-3012 Table-Top Research System with 0-1,000 cc/min Flowmeter ST1 34-1067 Outlet tube mount 23 mm for Vaporizer

ST1 72-3013 Table-Top Research System with Dual O2 Flowmeters ST1 34-1068 Inlet Tube Mount 23 mm for Vaporizer 0-1,000 cc/min; 0.2-4 LPM ST1 34-1264 Oxygen Flush System for rapid recovery Options: ST1 34-1406 Wall Mounting Kit for Large Bracket (optional) ST1 72-3013 Freestanding O2 Absorber System ST1 72-3074 Add on non-rebreathing adapter (replacement) Base Unit Option #2: Small Bracket 27.5 x 27.0 x 18.0 cm (10.8 x 10.6 x 7.1 in), H x W x D

Order # Product ST1 34-1352 Small Bracket System for 1-2 gasses

ST1 34-1420 O2 Flowmeter 0.2-2 LPM

ST1 34-1261 N2O Flowmeter 0.2-2 LPM ST1 34-0781 Medical Grade Room Air Flowmeter 0.2-2 LPM ST1 72-3043 Male Endcap ST1 72-3044 Female Endcap ST1 34-1404 Wall Mounting Kit for Small Bracket (optional)

168 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com ANESTHESIA MACHINES ANESTHESIA

Vaporstick Anesthesia Machine

• Non-rebreathing single animal anesthesia machine • 5-wheel spider base for increased stability • Supplied with Modified Jackson Rees with ½ liter bag, universal mounting bracket for vaporizers, end-caps and operation manual • Can be upgraded to a rebreathing system Mobile Post System • Vaporizer sold separately, see page 171

• Stable 5 wheel spider base Order # Product • Adapts to Anesthetic Bracket System, see page 168 ST1 72-3007 Vaporstick Anesthesia Machine Single O2 Flowmeter • Easily modified for room air or oxygen E-sized cylinders 0.2-4 LPM ST1 72-3009 Vaporstick Anesthesia Machine Order # Product Accessories and Replacement parts: Freestanding CO Absorber System ST1 34-1384 Basic Mobile Anesthetic Post ST1 72-3010 2 Single-O E-Cylinder Regulator and Double Tank Holder, ST1 34-1060 O Pin Index Regulator for E-sized compressed gas cylinders ST1 72-3018 2 2 see page 165 ST1 34-1257 Medical Grade Room Air Regulator for E-sized compressed Dual E-Cylinder O Tank Yokes Holder and Regulator gas cylinders ST1 72-3020 2 (must be ordered with ST1 72-2216), see page 165 ST1 72-2216 E-Cylinder Stabilizer (must be ordered with ST1 72-3020), see page 165 ST1 72-3017 Add-on Mayo Tray ST1 72-3074 Add on non-rebreathing adapter (replacement) ST1 72-3049 Z-Bracket Universal Vaporizer Mounting Bracket

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 169 ANESTHESIA MACHINES ANESTHESIA

Modular Anesthesia Trolley System

Create your own Modular Trolley System. Please be sure to include a regulator for E-Cylinders (page 166), trolley base unit, flowmeter , vaporizer (page 171) and scavenging system (pages 178-179). Custom Trolley Systems will be assembled and factory checked. Multiple Animal Systems

The best way to work with multiple animals is with our Multi- Order # Product Station Anesthesia System. There are three models available Trolley Base Unit: for 2, 4 or 6 animals. Each station is independently controlled ST1 34-1266 Basic Mobile Anesthetic Trolley, Base Unit providing you with exact anesthetic depth for each animal. Flowmeters for Trolley Base Unit:

ST1 34-0403 O2 Flowmeter 0.2-15 lpm, Long Series • One anesthesia machine for controlled anesthetic delivery for up to 6 animals at one time ST1 34-0404 N2O Flowmeter 0.1-12 lpm, Long Series ST1 34-1126 Air Flowmeter, Long Series • Ideal for high throughput small animal surgery ST1 34-1268 Mounting plate needed for ST1 34-0403, ST1 34-0404 • Mobile system on stable 5 wheel spider base for or ST1 34-1126 increased flexibility ST1 34-1262 Twin Flowmeter for O and N O 2 2 • Vaporizer not included ST1 34-1263 Twin Flowmeter for O2 and Air Options: • 2 year limited warranty ST1 34-1264 Oxygen Flush • Pair with Lab Animal Evacuation System, see page 178 ST1 34-1165 Low Oxygen Alarm (order with ST1 34-1265) ST1 34-1265 Oxygen Reservoir (order with ST1 34-1165) Order # Product ST1 34-1267 Nitrous Oxide Cut off (order with ST1 34-1265) ST1 72-3023 2 Station Multi-Station Lab Animal Anesthesia Machine ST1 72-3024 4 Station Multi-Station Lab Animal Anesthesia Machine ST1 72-3025 6 Station Multi-Station Lab Animal Anesthesia Machine

170 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com VAPORIZERS

Harvard Apparatus Classic T3 & Select-a-Tec Anesthetic Vaporizers Anesthetic Vaporizers • Precision style, cut of • All Harvard Apparatus circuit, single-agent vaporizers are new vaporizer and never refurbished • Temperature and flow • All vaporizers come compensated with a 3 year • Fill assembly is a one limited warranty piece design with no • Select-a-Tec Vaporizers solder joints available • 3 year limited warranty • Annual service available

Specifications Specifications Temperature Range 18° to 35°C Inlet Flow 50 ml to 10 lpm with minimal change in output Compensation Compensation concentration Calibration 21° and 35°C Temperature Range 15° to 35°C Accuracy within 10% when used in nominal working range Compensation Halogenated Gas 15.5 ml consumed over 30 minutes at 5 lpm and 2% Calibration 21°C Consumption Accuracy 15% (within above flow and temperature range) Liquid Capacity 160 ml liquid capacity, 66 ml absorbed by wick Duration of Use approximately 1.0 ml of liquid anesthetic is required Dimensions (H x W x D) & Weight: to provide 200 ml of vapor Funnel Fill 190 mm x 140 mm x 170 mm; 6.15 kg (13.56 lbs) Liquid Capacity 125 ml liquid capacity, 35 ml absorbed by wick Key Fill 210 mm x 140 mm x 170 mm; 6.10 kg (13.45 lbs) Dimensions (H x W x D) & Weight: Funnel Fill 18.4 x 12.7 x 14 cm (7.25 x 5 x 5.5 in); 7.27 kg (16 lbs) Order # Product Key Fill 18.4 x 12.7 x 15.2 cm (7.25 x 5 x 6 in); ST1 34-1040 Harvard Apparatus Isoflurane Funnel-Fill Vaporizer1 7.27 kg (16 lbs) ST1 34-1041 Harvard Apparatus Isoflurane Key-Fill Vaporizer1 1 ST1 34-1269 Harvard Apparatus Sevoflurane Funnel-Fill Vaporizer Order # Product ANESTHESIA ST1 34-1270 Harvard Apparatus Sevoflurane Key-Fill Vaporizer1 ST1 72-8132 Classic T3™ Isoflurane Funnel-Fill Vaporizer ST1 34-1259 Select-a-Tec Isoflurane Funnel-Fill Vaporizer ST1 72-7995 Classic T3™ Sevoflurane Funnel-Fill Vaporizer ST1 34-1172 Select-a-Tec Isoflurane Key-Fill Vaporizer ST1 72-7997 Classic T3™ Isoflurane Key-Fill Vaporizer ST1 34-1271 Select-a-Tec Sevoflurane Funnel-Fill Vaporizer ST1 34-1272 Select-a-Tec Sevoflurane Key Fill Vaporizer ST1 72-7996 Classic T3™ Sevoflurane Key-Fill Vaporizer ST1 34-1091 Select-a-Tec Manifold, must be ordered with Select-a-Tec Vaporizer1 1 When ordering a Harvard Apparatus Vaporizer with any system other NOTE: When ordered without an than the ST1 34-1405 or ST1 34-1352. please add SV to the part number, anesthesia machine, vaporizers do not i.e. ST1 34-1269SV. come with end-caps.

Vaporizer Accessories Vaporizer Endcaps

Order # Product Anti-Spill ST1 72-3051 Key-Fill Adapter Isoflurane Device ST1 72-3053 Key-Fill Adapter Sevoflurane ST1 34-0401 Harvard Apparatus Isoflurane Key Fill Applicator Key-Fill ST1 34-1391 Harvard Apparatus Sevoflurane Key Fill Applicator Adapter ST1 72-3054 Anti-Spill Device Isoflurane ST1 72-3056 Anti-Spill Device Sevoflurane ST1 72-3043 Male Endcap—Outlet ST1 72-3044 Female Endcap—Inlet

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 171 GAS DELIVERY

GAS DELIVERY Nose cones, circuit sets and induction boxes! We have many choices for you to configure your fresh halogenated gas delivery to your subjects. If you need ventilators please visit pages 185-190 for all of our Harvard Apparatus ventilators.

ANESTHESIA Rodent Circuit Set and Mask Modified Jackson Rees (MJR) Non-Rebreathing Anesthesia Circuit • Unique circuit designed specifically for rodent anesthesia • Built-in relief valve • Designed to eliminate rebreathing CO2 • Inlet tubing 6.25 mm (0.25 in), outlet is 22 mm (0.866 in) • Works with any size breathing bag respiratory fitting • Does not require a bain block • Works with any non-rebreathing anesthesia machine Order # Product

1 Order # Product ST1 72-3073 Modified Jackson Rees (Non-Rebreathing) & ⁄2 Liter Bag 1 ST1 72-3026 Rodent Circuit Set (hose, mask and uncut diaphragm) ST1 72-3075 Modified Jackson Rees Avian/Research Circuit & ⁄4 Liter Bag ST1 72-3027 Rodent Mask (no diaphragm)

7 ST1 72-3028 Rodent Mask Diaphragm Small, ⁄ 16 in Diameter

9 ST1 72-3029 Rodent Mask Diaphragm Medium, ⁄ 16 in Diameter

3 ST1 72-8030 Rodent Mask Diaphragm Large, ⁄4 in Diameter ST1 72-8131 Rodent Mask Diaphgram Uncut

Universal Rebreathing Anesthesia F-Circuit

• The universal F-Circuit is designed to maintain humidity and prevent heat loss • The F-circuit fits almost any anesthesia machine designed to deliver rebreathing anesthesia

Order # Product ST1 72-3071 F-Circuit with 2 L Bag, 101.6 cm (40 in) ST1 72-3072 F-Circuit without Bag, 152.4 cm (60 in) ST1 72-3082 F-Circuit Elbow

172 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com ANESTHETIZING MASKS

ST1 59-7977 Large Canine Ventilation Mask

Small Animal Anesthesia Masks

• For rats, guinea pigs, birds and mice Canine Ventilation/Anesthesia Masks • Simple, effective design • Durable polycarbonate masks are ideal for a • Simple cylinder with rubber diaphragm that tapers to variety of patients 15.3 OD x 11.9 mm ID port • The masks' diaphragms are made from durable rubber which reduces tearing

Order # Product 3 • Standard 15 mm ( ⁄5 in) taper for connection to ST1 59-8254 Mouse Anesthesia Mask anesthesia tubing

ST1 59-8255 Rat, Guinea Pig, and Bird Anesthesia Mask 3 • Large Mask opening is 4.4 cm (1 ⁄4 in) ST1 72-3923 Replacement Diaphragms, pkg. of 10 • Small Mask opening 2.5 cm (1 in)

Order # Product ST1 72-8206 Canine Ventilation/Anesthesia Mask, Small ST1 72-8203 Canine Ventilation/Anesthesia Mask, Large ST1 72-8207 Replacement Diaphragms for Small Mask ANESTHESIA

COAX Breathing Devices

• Height adjustable from mouse to small non-human primates • The Co-Axial breathing apparatus (COAX) is a precisely machined plastic (Delrin) apparatus for maintaining the surgical plane

1 • ⁄16 in side port inlet, one way exhalation through Cat Ventilation/Anesthesia Masks ball valve for proper scavenging • All COAX’s and COAX table systems come with two • Suitable for cats or other small animals mouse and rat masks (except where indicated) • Made from soft, pliable, transparent, vinyl plastic • The surgical table comes complete with metal strips compound to hold heating pads in place and towers for points • Small and medium sizes have molded on 15 mm standard of tie downs male connections • The overall dimensions for the surgical board is • Large Mask has standard 22 mm female connection which 40.6 x 31.8 cm (16 x 12.5 in) fits mask elbow or “Y” piece • Small Mask– 5.1 cm (2 in) diameter Order # Product Medium Mask– 7.6 cm (3 in)diameter ST1 72-7108 COAX-3 Height Adjustable Nose Cone 1 Large Mask– 14 cm (5 ⁄2 in) diameter ST1 72-7109 COAX-3 with Table ST1 72-7113 COAX-3 with Heated & Vented Table1,2 Order # Product ST1 72-7114 Heated and Vented Table3 ST1 59-8201 Cat Ventilation/Anesthesia Mask, Small 1 Heated water pump not included, see page 70. ST1 59-8202 Cat Ventilation/Anesthesia Mask, Medium 2 Vacuum pump not included. 3 COAX nose cones are not included. ST1 59-8203 Cat Ventilation/Anesthesia Mask, Large ST1 59-8204 Set of 3 Masks, one of each size

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 173 ANESTHETIZING CHAMBERS

Anesthetizing Boxes Induction Chambers

• Our most popular choice • Clear Acrylic for easy animal monitoring • Transparent 6 mm (� in) thick plastic for easy animal • Ideal for rodents monitoring and cemented joints • Stainless steel false bottom for easy clean up 5 • Comes with two 7.9 mm ( ⁄16 in) ports for introducing and 1 • ⁄4 in barbed inlet and outlet removing gasses • Small box opens lengthwise along machined grooves and Specifications is ideal for rodents Inner, Height x Diameter: • Large box is hinged for easy opening and fasteners Small 8.89 x 13.3 cm (3.5 x 5.25 in) squeeze the top against a rubber gasket for a tight seal ANESTHESIA Large 20.3 x 20.3 cm (8 x 8 in) • Large box is ideal for rabbits, cats and small Overall, Height x Diameter: non-human primates Small 17.8 x 17.8 cm (7 x 7 in) • Small box (H x W x D) 10.7 x 25.7 x 11 cm (4 x 10 x 4.5 in) Large 30.5 x 27.9 cm (12 x 11 in) • Large box (H x W x D) 29 x 44 x 29 cm (11.5 x 19.5 x 11.5 in) Order # Product Order # Product ST1 72-7110 Induction Chamber, Small ST1 50-0108 Anesthetizing Box, Small ST1 60-5246 Induction Chamber, Large ST1 50-0116 Anesthetizing Box, Large

CO2 Chambers with Anesthetizing Boxes Dump Door

• For anesthesia • Dump door enables CO2 induction to be cleared from the • Transparent Perspex chamber easily walls for easy animal • Dump door is located monitoring with below a false bottom cemented joints for easy cleaning • Nylon inlet and outlet • Top of the chamber ports 8 mm (0.3 in) closes with a latch • Magnetic rubber for against a foam seal sealing and closing cover Specifications • Rodent Anesthetizing Box, 24 x 15 x 15 cm Dimensions, H x W x D: (9.5 x 5.9 x 5.9 in) Large Chamber 305 x 305 x 455 mm (12 x 12 x 17.9 in) • Rabbit Anesthetizing Box, 40 x 29 x 29 cm Medium Chamber 200 x 200 x 200 mm (7.9 x 7.9 x 7.9 in) (15.7 x 11.4 x 11.4 in) Small Chamber 150 x 100 x 255 mm (5.9 x 3.9 x 10 in)

Order # Product Order # Product

ST1 76-0004 Anesthetizing Box for Rodents ST1 34-0434 CO2 Chamber with Dump Door, Large

ST1 76-0005 Anesthetizing Box for Rabbits ST1 34-0435 CO2 Chamber with Dump Door, Medium

ST1 34-0436 CO2 Chamber with Dump Door, Small

174 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com ANESTHETIZING CHAMBERS

ST1 34-0429 ST1 34-0430

ST1 34-0431 Specifications Dimensions, H x W x D: Large Chamber 315 x 305 x 455mm (12.4 x 12 x 17.9 in) Medium Chamber 210 x 200 x 305 mm (8.3 x 7.9 x 12 in) Small Chamber 160 x 100 x 255mm (6.3 x 3.9 x 10 in)

Order # Product

ST1 34-0429 Anesthetic/CO2 Chamber, Large

ST1 34-0430 Anesthetic/CO2 Chamber, Medium

ST1 34-0431 Anesthetic/CO2 Chamber, Small

Pneumatic Fittings for CO2 Chambers

Order # Product ANESTHESIA

1 ST1 34-0451 ⁄4" UNC Thread, Female Quick Release fitting for

CO2/Anesthetic Chambers ST1 34-0452 Male Quick Release with Push in Fitting for 6 mm (0.24 in) OD Anesthetic/CO2 Chambers Pneumatic Tubing ST1 34-0453 Coiled Tubing 6 mm (0.24 in) OD • White 6 mm (0.24 in) Perspex walls, clear Perspex ST1 34-0454 Pneumatic Tubing 6 mm (0.24 in) OD, Natural Color, available by special order sold per meter • 10 mm (0.4 in) thick clear Perspex lid that latches against a foam seal • Chamber has false aluminum floor for easy cleaning • Brass straight fittings are supplied for the inlet (below false floor) and outlet (top of chamber), 3 and fit with ⁄16" ID tubing

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 175 GAS DELIVERY MANAGEMENT

Directional Manifolds

• Economical • Organizational tool for reducing tubing clutter • When two are purchased they permit more than one breathing device to be used with one vaporizer and one Manifolds scavenging system • Custom sizes available • Economical

• Permits more than one breathing device to be used with Order # Product one vaporizer and one scavenging system ST1 75-0346 One Directional Manifold for Two Anesthetic Devices 1 • Additional stopcocks can be added to expand manifolds ST1 75-0347 One Directional Manifold for Three Anesthetic Devices • Fits with 8 mm (0.25 in) ID tubing ST1 75-0348 One Directional Manifold for Four Anesthetic Devices • Additional manifolds are available upon request ANESTHESIA

Order # Product ST1 60-5242 Manifold with 4 Ports for 2 Anesthetic Devices ST1 60-5243 Manifold with 6 Ports for 3 Anesthetic Devices ST1 60-5244 Manifold with 8 ports for 4 Anesthetic Devices ST1 60-5245 Stopcocks for use with Manifolds, pkg. of 2 1 Two stopcocks required to expand manifold by one device.

NOTE: Not suggested for use with multiple animals simultaneously.

Gas Flow Director

• Effective and simple connector to swap between two devices • Fits with 6 mm (0.24 in) ID tubing

Order # Product ST1 34-0393 Gas Flow Director

176 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com SCAVENGING & EVACUATION

Down Draft Table

• Robust downdraft table to capture halogenated gasses • Removable stainless steel work surface • Autoclavable • Comes in three versions: portable with blower cart, built into your bench-top to be interfaced with your ventilation system, or a fully contained mobile anesthesia workstation • Supplied with specially designed anesthetizing chamber

Specifications Dimensions: Down Draft Table 45.7 x 61.0 x 76.2 cm (18 x 24 x 30 in) (H x W x D) Work Surface 76.2 x 43.2 cm (24 x 17 in) (W x D)

Order # Product ST1 75-0240 Mobile Anesthesia: Surgical Suite with Downdraft Table 1,2,3 ST1 72-6201 Portable Down-Draft Table with Blower (must be purchased with ST1 72-6205) ST1 72-6202 Down Draft Table with Vent (for BenchTop) ST1 72-6203 Accessory Package for Aluminum Cart (Folding Shelves, Cabinet and Light) ST1 72-6204 Folding Shelves only ST1 72-6205 Anodized Aluminum Cart ST1 72-6206 Potassium Permangenate Filter, pkg. of 2 ST1 75-0240, shown with options ST1 72-6207 Carbon Filter, pkg. of 2 Front View ST1 72-6208 Carbon/Potassium Permangenate Filter 50/50, pkg. of 2 ST1 72-6209 HEPA filter, pkg. of 1

1 E-Cylinder, Regulator, Oxygen, Hose and flowmeter can be ordered on page 165. ANESTHESIA 2 Vaporizer can be ordered on page 171. 3 End-caps can be ordered on page 171.

ST1 75-0240, shown with options Rear View

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 177 SCAVENGING & EVACUATION

Lab Animal Evacuation System AES Gas Evacuation System • Designed to be used with the multistation in facilities that • Waste gas is collected by passive flow to the AES, do not have built-in, dedicated evacuation then is actively pushed up to 150 feet • Built in fan draws halogenated gasses through activated • Push blower can move collected waste gas up to charcoal allowing air to be recirculated 12 cubic feet/minute • Option to connect 2 in exhaust port to ventilation system • Two 19 mm inlets and one exhaust port allows for or directly outside the laboratory easy installation • Charcoal typically lasts for 8-10 hrs of surgery • Can be mounted onto a wall or anesthesia machine pole • System is supplied with 18 in and 10 ft length of 19 mm ID Order # Product

ANESTHESIA hose and 12.5 mm (0.5 in) PVC Adapter. ST1 72-3066 Lab Animal Evacuation System, 110 VAC, 60Hz • An optional outlet line ceiling plate cover is available to ST1 72-3046 Lab Animal Evacuation System, 230 VAC, 50Hz connect to inside ventilation system. ST1 72-3067 Charcoal Refill • AES is 14 in tall x 5 in diameter (35.6 x 12.7 cm), 5 lbs ST1 72-6000 Supply Line Adapter1 ST1 72-8209 Silicone Adapter1 Order # Product 1Note: To adapt part to 3/16" - 1/4" ID tubing ST1 72-3064 AES Gas Evacuation System, 110 VAC, 60Hz ST1 72-3065 AES Gas Evacuation System, 220 VAC, 50Hz Accessories: Scavenger Interface Valve ST1 72-3093 19 mm (0.75 in) ID Hose, 3 m (10 ft) for Active Systems ST1 72-3085 Male Union Adapter 19 mm x 19 mm ST1 72-3070 Ceiling Plate Cover • The Scavenger Interface Valve ST1 72-6001 19-22 mm Adapters is a central manifold designed to channel waste gas from your anesthesia system to your active scavenging system of choice F/Air Filter Canister • Manifold allows for easy regulation of the amount of scavenging • Our most popular taking place allowing for proper scavenging choice balance of your set-up • Easy and economical • Includes pair of relief valves for • Removes up to 50 g of balancing positive and negative halogenated gas and can pressure, an adjustable needle be thrown away in regular valve to control active scavenging, trash two 19 mm-nominal-male 1 • Each canister is 15.2 cm (6 in) high x 8.3 cm (3 ⁄4 in) connectors, and reservoir bag diameter and 200 g before use • Intended to be post mounted

Order # Product Order # Product ST1 60-0979 F/Air Filter Canister, pkg. of 1 ST1 72-2217 Scavenger Interface Valve for Active Systems ST1 72-1294 F/Air Filter Canisters, case of 8

3 ST1 60-5251 Connector to Standard ⁄ 16" ID tubing ST1 75-0345 F/Air Filter Canister Holder

178 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com FLUOVAC & ACCESSORIES

ST1 34-0415 Fluosorber

• Activated charcoal canister that is packed to optimize halogenated gas absorption • Stand-alone for passive scavenging or used with the Fluovac for efficient active scavenging • Canister weights 1,200 g (2.65 lbs) before use and 1,400 g (3.1 lbs) when full • Canister is designed to scavenge 200 g of anesthetic agent and then can be thrown away in regular trash or incinerated in supplied bags • Fluosorber is factory tested with an air flow of 60 LPM to

ensure resistance is not above 2 cmH2O

Order # Product ST1 34-0415 Fluosorber Canisters, case of 6

Fluovac Exhaust Tube Mount Fluovac System and Accessories • 22 mm tapered • Actively absorbs anesthetic vapors from work area adapter that fits into protecting personnel from exposure the exhaust port on • Specially designed nose cones allow optimal access to the Fluovac Base Unit animals during surgery in order to adapt to ST1 34-0392 tubing allowing the ANESTHESIA • Four different mask sizes available for user to vent gasses mice through rabbits (see next page) like nitrous oxide • Incorporates special double-mask design to supply and • Fits with item ST1 34-0426 corrugated plastic tubing scavenge anesthetic gasses simultaneously • Requires minimal maintenance Order # Product • Supplied with size 1 dual arm (rat) ST1 34-0392 Fluovac Exhaust Tube Mount • Fluosorber canisters ordered separately

Specifications Fluovac Mask Support Overall Dimensions 180 x 275 x 300 mm (7.1 x 10.8 x 11.8 in), (H x W x D) base unit only • Used to hold Fluovac Weight 8 kg (17.6 lbs) Masks in place on a flat (Including Fluosorber) surface Weight 7 kg (15.4 lbs) Fluovac (Excluding Flusorber) Mask Support Power 240 VAC, 50 Hz; 110 VAC, 60 Hz; 37 Watts Order # Product Order # Product ST1 34-0394 Fluovac, Mask Support for Size 1 Masks ST1 34-0387 Fluovac, 240 VAC, 50 Hz ST1 34-0395 Fluovac, Mask Support for Size 2 Masks ST1 34-0388 Fluovac, 110 VAC, 60 Hz ST1 34-0396 Fluovac, Mask Support for Size 3 Masks

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 179 FLUOVAC & ACCESSORIES

ST1 34-0389 Directavalve

• Directs gas flow in one of two directions by turning a valve

Order # Product ST1 34-0459 Directavalve

ST1 34-0402 Fluovac Isolator Valve ST1 34-0391 • Redirects gas from a Fluovac Mask when the mask is no longer in use • Alleviates needing to change the flowmeter or vaporizer setting to compensate • Keeps Fluovac balanced when an animal is removed by opening a channel to room air and directing gas to scavenging system

ANESTHESIA • Valve works by a push-pull control knob that you set to the appropriate setting • Please state which size masks are in use at time of order

ST1 34-1379 Order # Product ST1 34-0402 Fluovac Isolator Valve* *This valve is a registered design.

Fluovac Mask

• Specially designed double mask sets that allow for proper fresh anesthetic gas delivery and proper waste Portable Scavenged Anesthesia Table for Mice gas removal • Harvard Apparatus developed a quick and easy solution • Sized specifically for rodents for a down-draft table that is specifically for mice • Delivers and scavenges halogenated gasses Order # Product • Connect to your anesthetic agent for fresh gas delivery ST1 34-1379 Fluovac Mask Size 0.5 Single Arm (Mice) and connect table via 22 mm bore tubing to the Fluovac ST1 34-1421 Fluovac Mask Size 0.5 Dual Arm (Mice)* system for scavenging ST1 34-0389 Fluovac Mask Size 1 Dual Arm (Rats) • Rat size is available, please call for details ST1 34-0390 Fluovac Mask Size 2 Dual Arm (Guinea Pig) ST1 34-0391 Fluovac Mask Size 3 Single Arm (Rabbit) Order # Product ST1 34-1411 Scavenged Anesthesia Platform ST1 34-0909 22 mm Bore Tubing

180 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com FLUOVAC & ACCESSORIES

ST1 34-0457

Fluovac Tube Restrainer

• Used to quickly induce a subject that cannot be held against the nose cone • Subject is restrained with rear holding bar • Fits with size 1 mask • Scavenges and delivers anesthetic gas • Internal diameter 57 mm (2.24 in), length is adjustable up to 200 mm (7.87 in)

Order # Product ST1 34-0457 Fluovac Tube Restrainer

Fluovac Anesthetizing Chambers and Systems ANESTHESIA • Fluovac Anesthetizing chambers are designed to work specifically with the Fluovac • Made of clear Perspex with false floor for easy cleaning • 6 mm inlet located below false floor and outlet is specially ST1 34-0455 designed to include air bleeds to optimize scavenging ST1 34-0456 • Fluovac Anesthetizing Systems come complete with inlet tube mount, outlet tube mount, 6 mm ID PVC tubing, Scavenged Anesthetizing Chambers includes (1) Directavalve and (1) gas flow director, and 22 mm ID tubing, plus large or small chamber • Simply plug a size 1 mask into the rear socket and turn on the Fluovac and gas supply Specifications • Enables researcher to keep an animal induced while Dimensions, H x W x D: performing a procedure on another Large 200 x 200 x 305 mm (7.9 x 17.9 x 12 in) • Large and small chambers fit with size 1 masks Small 134 x 128 x 170 mm (5.3 x 5 x 6.7 in) • Made from clear Perspex enabling end user to see when animal has been anesthetized, then the inner chamber Order # Product slides forward and gas supply is diverted and scavenged ST1 34-0460 Anesthetizing Chamber, Large Anesthetizing Chamber, Small ST1 34-0462 Specifications ST1 34-0458 Fluovac Anesthetizing Chamber Dimensions, H x W x D (Inner Chamber Only): with Gas Scavenging System, Large Large 110 x 160 x 260 mm (4.3 x 6.3 x 10.2 in) ST1 34-0461 Fluovac Anesthetizing Chamber with Gas Scavenging System, Small Small 98 x 106 x 130 mm (3.9 x 4.2 x 5.1 in)

Perspex is a trademark of Lucite Interantional. Order # Product ST1 34-0455 Scavenged Anesthetizing Chamber, Large ST1 34-0456 Scavenged Anesthetizing Chamber, Small

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 181 RESPIRATORY VALVES

ST1 60-3174 ST1 60-3173 ST1 60-3172 ST1 60-3171 ST1 60-3168 ST1 60-3164

One Way Respiratory Valves

• One way respiratory valves (check valves) are designed to be used for uni-directional respiratory circuits • Function in any position and are not gravity dependent • Very sensitive to low flows • Unique non-sticky Spiral-Type™ diaphragm with excellent elastic memory • Transparent outlet port tube for visibility of diaphragm ANESTHESIA • Threaded construction provides convenient disassembly and cleaning • All 15 mm and 22 mm taper male and female connectors are ISO certified

Two Way Non-Rebreathing Valves

Resistance to Flow, Differential Pressure (dP) in cmH2O Flow lpm Order # Valve Size OD (mm) ID (mm) 2 4 6 8 10 15 20 25 30 35 ST1 60-3164 Miniature 10.5 7.5 0.5 0.6 0.7 0.8 1 1.8 3 4.6 6.4 8.5 ST1 60-3165 Miniature 15 10.5 0.4 0.5 0.6 0.7 1.1 2.2 3.8 5.7 8.1 10.8 ST1 60-3166 Miniature 22 15 0.6 0.7 0.8 0.9 1.1 2.2 3.8 5.6 7.7 10.3 ST1 60-3167 Extra Small 10.5 7.5 0.6 0.8 0.9 1 1.2 1.6 2.1 2.6 3.4 4.1 ST1 60-3168 Extra Small 15 10.5 0.5 0.6 0.7 0.7 0.8 1.1 1.3 1.7 2.1 2.5 ST1 60-3169 Extra Small 22 15 0.4 0.5 0.6 0.7 0.8 1 1.2 1.5 1.8 2.2 Order # Valve Size OD (mm) ID (mm) 20 60 100 140 180 200 300 400 500 600 700 ST1 60-3170 Small 22 15 0.5 0.9 1.7 2.9 5 6.3 ST1 60-3171 Small 25.4 22 0.6 1 1.7 3 5 6.3 ST1 60-3172 Small1 22 15 0.5 0.9 1.7 2.9 5 6.3 ST1 60-3173 Medium 35 28.6 1.6 4.7 8.8 ST1 60-3174 Large 35 28.6 0.5 0.8 1.3 2 3 4.1 5.5 6.9 1 Note: Autoclavable One-Way Respiratory Valve.

Spiral-Type is a trademark of Hans Rudolph, Inc.

182 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com RESPIRATORY VALVES

Two Way Non-Rebreathing Valves

These are available in T or Y-shaped configurations and allow for separation of expired air for collection or use with pneumotachometers. Additional sizes are available. Please call. • Inhalation and exhalation ports use a Spiral-Type™ diaphragm to direct flow, which is a patented uni-directional diaphragm ST1 59-9379 ST1 59-9374 • Function in any position and are not gravity dependent • Very sensitive to low flows • Spiral-Type™ diaphragm has a patented long life, non-sticking and maintains excellent elasticity and sensitivity • Easily customized

ST1 59-9371 ST1 59-9370

Two Way Non-Rebreathing Valves for Small Animals

Resistance to Flow, Differential Pressure (dP) in cmH2O Inhalation, Exhalation and Mouth Ports Flow in Liters/Min Order # Size/Shape OD ID Flow Path2 Dead Space3 2 4 6 8 10 20 26 ST1 59-9370 Miniature T 3.2 mm diameter - I 0.5 ml 0.7 1.2 2.0 3.2 5.1 – – hole in valve body 7.9 mm 6.4 mm1 E 0.5 ml 0.7 1.4 2.3 3.4 4.9 – – ST1 59-9371 Miniature T Female Luer Lock - I 0.8 ml 0.9 1.6 2.8 4.3 6.2 – – with 2.8 mm flow orifice 7.9 mm 6.4 mm1 E 1.0 2.2 4.0 6.2 9.2 – – ANESTHESIA ST1 59-9372 Miniature T 7.9 mm 5.1 mm I 1.3 ml 0.5 0.8 1.0 1.4 1.9 6.3 – 7.9 mm 6.4 mm1 E 1.3 ml 0.5 1.0 1.5 2.2 3.0 9.3 – ST1 59-9373 Miniature T 22 mm 15 mm I 3.6 ml 0.6 0.8 1.2 1.7 2.3 8.4 – 7.9 mm 6.4 mm1 E 3.6 ml 0.6 0.9 1.4 2.0 2.9 9.8 – ST1 59-9377 Miniature Y 7.9 mm 6.4 mm I 1.4 ml 0.5 0.6 0.8 1.1 1.5 5.2 9.1 7.9 mm 6.4 mm E 1.4 ml 0.5 0.6 0.7 0.9 1.2 3.8 6.2 ST1 59-9374 Miniature Y 10.5 mm 7.5 mm I 1.7 ml 0.6 0.8 1.0 1.3 1.8 5.5 9.0 10.5 mm 7.5 mm E 1.7 ml 0.4 0.6 0.7 1.0 1.2 3.9 6.1 ST1 59-9375 Miniature Y 15 mm 10.5 mm I 2.1 ml 0.5 0.7 1.0 1.3 1.8 6.0 9.7 15 mm 10.5 mm E 2.1 ml 0.4 0.6 0.8 1.1 1.5 4.7 7.4 ST1 59-9376 Miniature Y 22 mm 15 mm I 3.4 ml 0.5 0.8 1.0 1.3 1.7 5.9 9.3 22 mm 15 mm E 3.4 ml 0.5 0.7 0.9 1.2 1.5 4.4 7.0 ST1 60-3121 Extra Small T 10.5 mm 7.5 mm I 3.8 ml 0.6 0.6 0.8 0.9 1.0 2.0 2.7 10.5 mm 7.5 mm E 3.8 ml 0.6 0.7 0.8 1.0 1.2 2.5 3.4 ST1 60-3122 Extra Small T 15 mm 10.5 mm I 4.2 ml 0.5 0.6 0.7 0.8 0.9 1.5 1.8 15 mm 10.5 mm E 4.2 ml 0.5 0.6 0.7 0.8 0.9 1.6 2.1 ST1 60-3123 Extra Small T 22 mm 15 mm I 5.8 ml 0.5 0.6 0.7 0.8 0.9 1.6 2.0 22 mm 15 mm E 5.8 ml 0.5 0.6 0.7 0.8 1.0 1.7 2.2 ST1 59-9378 Extra Small Y 10.5 mm 7.5 mm I 3.3 ml 0.3 0.5 0.6 0.8 1.0 2.1 2.8 10.5 mm 7.5 mm E 3.3 ml 0.4 0.6 0.8 0.9 1.1 2.2 2.9 ST1 59-9379 Extra Small Y 15 mm 10.5 mm I 3.8 ml 0.5 0.6 0.7 0.8 1.1 1.7 2.1 15 mm 10.5 mm E 3.8 ml 0.5 0.6 0.7 0.8 0.9 1.5 1.8 ST1 59-9380 Extra Small Y 22 mm 15 mm I 5.3 ml 0.5 0.6 0.7 0.8 0.9 1.6 2.1 22 mm 15 mm E 5.3 ml 0.5 0.6 0.7 0.8 0.9 1.6 2.0 1 Note: Inhalation and exhalation port measurements. 2 Note: (I) is inspired and (E) is expired. 3 Note: Dead space volume includes housing and mouth port tube.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 183 RESPIRATORY ACCESSORIES

Respiratory Adapters

• Polypropylene adapters used to connect common size respiratory tubing

Tygon® Laboratory Tubing (E-3603) Order # Product ST1 72-2889 Respiratory Adapter, 6 to 22 mm (0.24 to 0.87 in), pkg. of 10 • Less permeable than rubber tubing ST1 72-2890 Respiratory Adapter, 8 to 22 mm (0.31 to 0.87 in), pkg. of 10 • Autoclavable, durometer hardness: Shore A, 55 ST1 72-2891 Respiratory Adapter, 10 to 22 mm (0.39 to 0.87 in), pkg. of 10 • More sizes available. Please call ST1 72-2892 Respiratory Adapter, 12 to 22 mm (0.47 to 0.87 in), pkg. of 10 ST1 72-2893 Respiratory Adapter, 15 to 22 mm (0.59 to 0.87 in), pkg. of 10 ID OD ID OD Length Length ST1 72-2894 Respiratory Adapter, 18 to 22 mm (0.71 to 0.87 in), pkg. of 10 Order # (mm) (mm) (in) (in) (m) (ft)

1 1 ST1 72-1015 1.6 3.2 ⁄ 16 ⁄8 15.2 50

1 1 ST1 72-1020 3.2 6.4 ⁄8 ⁄4 15.2 50 ST1 34-0399 Halovet Tube Mounts 3 5 ST1 72-1024 4.8 7.9 ⁄ 16 ⁄ 16 15.2 50

1 3 • Convenient tube ST1 72-1026 6.4 9.5 ⁄4 ⁄8 15.2 50 mounts used with Fluovac systems and Fluosorber canisters

• Also can be used for ST1 34-04020 22 mm ports on ST1 34-0400 vaporizers ANESTHESIA

Order # Product ST1 34-0399 Halovet Inlet Tube Mount for 22 mm Vaporizers ST1 34-0400 Halovet Outlet Tube Mount for 22 mm Vaporizers ST1 34-1067 Endcap for ST1 34-1246 ST1 34-1068 Outlet Endcap for ST1 34-1246 High Pressure Tubing

ID OD ID OD Length Length Order # (mm) (mm) (in) (in) (m) (ft) Color

ST1 34-0423 6.0 13.0 0.236 0.512 1 33 Black, CO2 or Air ST1 34-0420 6.0 13.0 0.236 0.512 1 33 Black with Yellow Line Platinum Cured Silicone Tubing

• Ultra-pure biocompatible tubing • Autoclavable, durometer hardness: Shore A, 61 • More sizes available. Please call

ID OD ID OD Length Length Order # (mm) (mm) (in) (in) (m) (ft)

1 3 ST1 72-1049 1.6 4.8 ⁄ 16 ⁄8 7.6 25

1 3 ST1 72-10609 3.2 4.8 ⁄8 ⁄ 16 7.6 25

3 5 ST1 72-1079 4.8 7.9 ⁄ 16 ⁄ 16 7.6 25

1 3 ST1 72-1026 6.4 9.5 ⁄4 ⁄8 7.6 25 Flexible Tubing

Corrugated tubing to fit all 22 mm tapered male tube mounts. Silicone Tubing Supplied as 10 m roll, which is sectioned every 38 cm.

ID OD ID OD Length Length Order # Product Order # (mm) (mm) (in) (in) (m) (ft) ST1 34-0426 Plastic Tubing, 22 mm Taper, 10 m ST1 34-0421 6.0 10.0 0.236 0.394 1 33

184 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com VENTILATORS

Harvard Apparatus has manufactured high quality animal ventilators for more than . 75 years. These ventilators are based on designs of Dr. William T. Porter, a Professor of . Physiology at Harvard Medical School. Dr. Porter was a strong proponent of physiology education and training through The American Physiological Society and the founder of . Harvard Apparatus. Our range of animal ventilators covers from neonatal mice through large dogs.

PRODUCT PAGE

Ventilators...... 186-190. Inspira Advanced Safety Ventilators...... 186 Models 687 and 683 Mouse and Small Animal Ventilators...... 187 MicroVent Prenatal Mouse Ventilator...... 187 MiniVent Mouse Ventilator...... 188 MidiVent Large Mouse and Small Rat Ventilator...... 188 NEW HSE-HA Pressure Monitor and Limiter for Small Animals...... 189 Model 613 Large Animal Ventilator...... 190 Nebulizers...... 191 Ventilator Accessories...... 192-196 Ventilator Connection Kits...... 192 Endotracheal Tubes...... 192 Intubation and Tracheal Cannulae...... 193 Fiber Optic Laryngoscope Sets...... 195 Intubation Stand...... 196 VENTILATORS

Inspira Advanced Safety Ventilator (ASV), see page 186

MiniVent Ventilator for Mice, see page 188

185

O, 2

O) 2 O 2 O or 35 cmH O or 35 2

in- 27NPT, 8 ⁄ 1 O (Default = -5 cmH O O 2 2 O typical (40.0mV/mmHg, typical) O typical (40.0mV/mmHg, 2 in- 27NPT, in- 27NPT, 2 16 ⁄ 1 O (�50 mmHg) www.harvardapparatus.com 2 O 2 O 2 web in-27NPT threaded nylon barbed ports threaded nylon barbed in-27NPT 16 ⁄ Inspiratory Pressure + 10 cmH 15 g to 10 kg 0.1 to 100 ml 4 of each 3 +0.5 to +4.5V +2.5V�0.05V 1 ms max Not Used RS-232 2 line x 20 character Vacuum Fluorescent Display (VFD) Watts Hz, 75 V, 50/60 AC 100 to 240 17.8 x 25.4 x 40.6 cm (8 x 10 x 17.25 in) 9.1 kg (20 lbs) 1 to 120 sec 1 to 60 sec 1 cmH 1 in 5 to 1 in 250 breaths (Default = No Sigh) 1 in 5 to 1 in 250 breaths Inspiratory Pressure to 50 cmH 30mV/cmH 15 to 25 cmH �1 cmH whichever is less Available -1 to -10 cmH 0 to +5V digital pulse, active low 0 to +5V digital pulse, 20�10 ms wide, active low VOH for Inspiration Duration VOL for Expiration Duration 0 to +5V analog (Default = Airway Pressure Signal) cmH �67 Volume or Pressure, Assist Volume or Pressure, 5 to 200 bpm 1 breath/min = 50%) 20-80% of cycle time (default 4:1 to 1:4 (Default 1:1) 0 to 12 SLPM mixed gas Room air or non-flammable 5 to 50 cmH

with Inspiratory Hold (ASVv-IH) Inspira Advanced Safety Ventilator Pressure Controlled with Inspiratory Hold (ASVp-IH) Connection Kit for Inspira Advanced Safety Ventilator for Pressurized Gasses Upgrade Inspira Ventilator Volume Controlled to Pressure Controlled Upgrade Inspira Ventilator Volume Controlled to Include Inspiratory Hold Feature Upgrade Inspira Ventilator Pressure Controlled to Include Inspiratory Hold Feature Product Inspira Advanced Safety Ventilator Volume Controlled (ASVv) Inspira Advanced Safety Ventilator Pressure Controlled (ASVp) Inspira Advanced Safety Ventilator Volume Controlled

Full Range Safe Rage Safe Range Full Range Safe Range External Trigger Input Sync Out (ASVv) Sync Out (ASVp) Full Range ST1 55-7062 Accessories ST1 73-3076 Upgrades ST1 73-3076 ST1 55-7063 ST1 55-7063 # Order ST1 55-7058 ST1 55-7059 ST1 55-7061 Specifications Animal Size Volume Port Sizes Signal Level Offset Response Analog Out 2 Remote Communications Display Power Dimensions, H x W x D Weight Inspiratory Hold Time: Resolution Sigh Frequency Sigh Pressure: Sensitivity Accuracy Respiratory Assist Assist Trigger Signal Input: Signal Output: Analog Out 1 Airway Pressure Signal Pressure Range Control Modes Breathing Rate Resolution % Inspiratory Time I:E Ratio Inspiratory Flow Gas Supply Inspiration Pressure: [email protected] email 1-508-893-8999 To order call - Volume-Controlled ASVv - Pressure-Controlled ASVp - Volume-Controlled Inspiratory Hold ASVv-IH - Pressure-Controlled Inspiratory Hold ASVp-IH Ventilate mice to cats with one ventilator (15 g-10 kg) Ventilate mice to cats with one ventilator Microprocessor controlled Easy to use Four models available: Respiration rates from 5 to 200 bpm 100 ml Tidal volume is adjustable from 0.1 ml to Pressure monitoring detects over/under pressure Pressure monitoring detects over/under of system Assist mode for anesthetic weaning Built in sigh breath for optimal lung functioning Adjustable I/E ratio (1:4 to 4:1) Ideal for imaging studies Available on both volume and pressure controlled models Hold is actuated by pressing the “Inspiratory Hold” button on the keypad SafeRange™ Software requires the weight of the animal and it autopopulates an appropriate tidal volume and breathing rate Programmable sigh breaths free researchers up while maintaining optimal lung function Audible alarms for over and underpressure Analog output of data Built-in pressure sensor monitors system pressure conveying over/under pressures Pressure models also convey occlusion or high PEEP PEEP feature to maximize physiologically normal respiratory function • • • • • • • • • • • • • • • • • • • •

One Ventilator—Many Animals Features Key (ASV) Ventilator Safety Advanced Inspira VENTILATORS Inspiratory Hold Easy to Use Pressure Monitoring

VENTILATORS 186 VENTILATORS

683 Small Animal and 687 Mouse Ventilators MicroVent Prenatal Mouse Ventilator Model 848

• Ability to administer PEEP • Ideal for very small animals; perinatal mice, • Permanent etched volume graduations on the cylinder small birds (<18 g) • Linear volume and rate control • Stroke volume 0-130 µl • CE Approved • Ventilation rate from 60-400 breaths/minute • Valveless piston pump Model 683 for Small Animals 250 g to 5 kg (11 lbs) • Very small instrument and circuit dead space (<3 µl) • Includes two piston and cylinder assemblies, 5 cc cylinder • Compact construction adjustable from 0.5 to 5 cc in 0.5 cc increments, and 30 cc • Silent operation and no vibrations cylinder adjustable from 3 to 30 cc in 0.3 cc increments. • Optional multi-gas inlet adapter available for gas mixtures Model 687 for Mice and Perinatal Rats up to 200 g and nebulized substances, see page 191 • Includes a single 1 cc piston and cylinder assembly with • Supplied with: tidal volume range 0.1 to 1 cc in 0.1 cc increments. - Silicone Tubing, 1.5 mm ID, 3.0 mm OD, 14 cm length, pkg. of 2 Specifications - ST1 73-2731 1.5 mm OD Tracheotomy Cannula, Model 683 687 pkg. of 1 Rate Adjustable from 30 to 150 strokes/min while the ventilator is running - ST1 73-2737 1.5 mm OD Intubation Cannula, pkg. of 1 Phase Ratio 1:1 Fixed Dimensions, H x L x W 25 x 32.5 x 20 cm (10 x 13 x 7.9 in) Specifications Weight 9.5 kg (21 lbs) Stroke Volume Continuously adjustable from 0 to 130 µl Power 115/230 VAC, 50/60 Hz Respiratory Rate Continuously adjustable from 60 to 400 breaths/minute Ventilator Small Animal Mouse VENTILATORS 12 VDC, 0.5A through external mains adapter Tidal Volume Adjustable from 0.2 to Adjustable from 0.05 Power 30 ml/stroke while the to 1 ml/stroke while the Dimensions, H x W x D 8 x 10 x 20 cm (3.2 x 3.9 x 7.9 in) ventilator is running ventilator is running Weight 3 1 1 Port Size, ID ⁄ 16", ⁄8" ⁄ 16" MicroVent 1 k g (2.2 lbs) AC Adapter 0.3 kg (0.7 lbs) Order # Product ST1 55-0000 Model 683, Small Animal Volume Controlled Ventilator Order # Model Product ST1 55-0001 Model 687, Mouse Volume Controlled Ventilator ST1 73-3591 848 MicroVent Ventilator, 115 VAC, 60 Hz ST1 55-0006 Retrofit Model 683, for models pre-2008 ST1 73-3590 848 MicroVent Ventilator, 230 VAC, 50 Hz ST1 55-0007 Retrofit Model 687, for models pre-2008 Options: Accessories: ST1 73-3077 Connection kit for MicroVent, MiniVent and MidiVent ST1 73-3076 Connection Kit for 683 and Inspira Advanced Safety Ventilator Ventilators for pressurized gas for pressurized gas ST1 73-4008 Trigger Output Option for End of Inspiration1 ST1 73-3077 Connection Kit for 687, MicroVent, MiniVent and MidiVent 1 Ventilators for pressurized gas ST1 73-4013 Trigger Output Option for End of Expiration Replacement Parts1: Replacement Parts: ST1 55-5281 Overhaul Kit for 687 Ventilator 1 cc Cylinder ST1 73-2731 Replacement Tracheotomy Cannula, 1.0 mm OD ST1 55-5282 Overhaul Kit for 683 Ventilator 5 cc Cylinder ST1 73-2737 Replacement Intubation Cannula, 1. 0 mm OD ST1 55-5283 Overhaul Kit for 683 Ventilator 30 cc Cylinder ST1 73-0027 Small Y adapters, each with 2x silicone tubing 1.5 mm ID, 3 mm OD, 14 cm Long, pkg. of 10 1Note: For models older than 2008 please call. 1Must be ordered at time of MicroVent Purchase, or requires an RMA

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 187 l

www.harvardapparatus.com web Continuously adjustable from 60 to 400 breaths/minute 12 VDC, 0.5A through external mains adapter 8 x 10 x 20 cm (3.2 x 3.9 x 7.9 in) 1 kg (2.2 lbs) 0.3 kg (0.7 lbs) Continuously adjustable from 60 to 700 µ Continuously adjustable from 60 to 700 Product MidiVent Ventilator for Mice, 115 VAC, 60 Hz MidiVent Ventilator for Mice, 230 VAC, 50 Hz Connection kit for MicroVent, MiniVent and MidiVent Ventilators for pressurized gas Trigger Output Option for End of Inspiration� Trigger Output Option for End of Expiration� cannula and connecting tubes Replacement Tracheotomy Cannula, 1.3 mm OD Replacement Intubation Cannula, 1.2 mm OD Replacement Tracheotomy Cannula, 1.5 mm OD Replacement Intubation Cannula, 1.5 mm OD Small Y Adapters, each with 2x silicone tubing 1.5 mm ID, mm OD, pkg. of 10 Medium Y Adapters, each with 2x silicone tubing 6 mm ID, 9 mm OD, 80 cm long, pkg of 5 Product Replacement Y-piece with 1.3 mm OD tracheal Model 849 845 Silicone Tubing, 1.5 mm ID, 3.0 mm OD, 14 cm length, Silicone Tubing, 1.5 mm ID, 3.0 mm OD, 14 pkg. of 2 -  1.5 mm OD Tracheotomy Cannula, pkg. of 1 - ST1 73-4112 1.5 mm OD Intubation Cannula, pkg. of 1 - ST1 73-4115 Ideal ventilator for large mice and small rats (<100 g) Ideal ventilator for large µl from 60 to 700 Stroke volume range 60 to 400 breaths/minute Ventilation rate from Valveless piston pump dead space volume Very small instrument/circuit Compact construction Silent operation, no vibrations for gas mixtures Optional multi-gas inlet adapter available and Nebulized substances, see page 191 Supplied with: MidiVent AC Adapter • • • • • • • • • for Ventilator MidiVent and Small Rats Mice Large ST1 73-2730 ST1 73-2844 ST1 73-4112 ST1 73-4115 ST1 73-0027 ST1 73-0032 # Order ST1 73-0049 # Order ST1 73-4120 ST1 73-0044 Options: ST1 73-3077 ST1 73-4008 ST1 73-4013 Respiratory Rate Power Dimensions, H x W x D Weight: Specifications Stroke Volume �Must be ordered at time of MicroVent Purchase, or requires an RMA Parts Replacement l

[email protected] email

1-508-893-8999 400 breaths/minute 12 VDC, 0.5A through external mains adapter 8 x 10 x 20 cm (3.2 x 3.9 x 7.9 in) 1 kg (2.2 lbs) 0.3 kg (0.7 lbs) Continuously adjustable from 30 to 350 µ Continuously adjustable from 30 to 350 Continuously adjustable from 60 to Product MiniVent Ventilator, 115 VAC, 60 Hz MiniVent Ventilator, 230 VAC, 50 Hz Connection kit for MicroVent, MiniVent and MidiVent Ventilators for pressurized gas Trigger Output Option for End of Inspiration� Trigger Output Option for End of Expiration� Product Battery Pack for MicroVent, MiniVent, and MidiVent Model 845 845 To order call Silicone Tubing, 1.5 mm ID, 3.0 mm OD, 14 cm length, pkg. of 2 1.3 mm OD Tracheotomy Cannula, pkg. of 1 ST1 73-2730 -  - 1.2 mm OD Intubation Cannula, pkg. of 1 - ST1 73-2844 Provides transportability while under ventilation Up to 100 hrs of use from a single charge Lithium Polymer Battery 6,600 mAh capacity Ideal ventilator for mice, prenatal rats, Ideal ventilator for mice, or small birds (<50 g) µl from 30 to 350 Stroke volume range 60 to 400 breaths/minute Ventilation rate from Valveless piston pump dead space volume Very small instrument/circuit Compact construction Silent operation, no vibrations for gas mixtures Optional multi-gas inlet adapter available and nebulized substances, see page 191 Supplied with: MiniVent AC Adapter • • • • • • • • • • • •

ST1 73-4127 # Order Power Dimensions, H x W x D Weight: # Order ST1 73-0043 Specifications Stroke Volume Respiratory Rate ST1 73-0044 Options: ST1 73-3077 ST1 73-4008 ST1 73-4013 MicroVent, for Pack Battery MidiVent MiniVent, �Must be ordered at time of MicroVent or MidiVent Purchase, or requires an RMA. VENTILATORS Mice for Ventilator MiniVent

VENTILATORS 188 VENTILATORS

Specifications Valve Opening Delay 10 msec max

Pressure Range 10-50 cmH2O

Recording Output 0-4 V (50m V/cmH2O) for pressure Adjustable Valve 50-500 msec Open Time Trigger Output TTL (Low for valve open) Connectors: Pressure Recording BNC TTL Output BNC Port Sizes: Mouse Actuator ID = 1.5 mm, OD = 2.0 mm Rat Actuator ID = 3.5 mm, OD = 4.0 mm Power Supply 12 VDC through external main adapter 100-240 VAC Dimensions (W x D x H): Pressure Monitor 150 x 100 x 55 mm (5.9 x 3.9 x 2.2 in) & Limiter Actuator 65 x 42 x 25 mm (2.6 x 1.7 x 1 in) Head Mouse Actuator Head Rat 80 x 48 x 28 mm (3.1 x 1.9 x 1.1 in) Certifications CE

Order # Product ST1 73-4329 Respiratory Pressure Monitor & Limiter for Mouse, including Actuator Head Mouse type 384/I and Respiratory Pressure Monitor & Limiter type 870/I and bar with magnet holder, 100-240 VAC, 50/60 Hz HSE-HA Pressure Monitor & Limiter ST1 73-4330 Respiratory Pressure Monitor & Limiter for Rat, including Actuator Head Rat 384/2 and Respiratory Pressure Monitor & for Small Animal Limiter type 870/I and bar with magnetic holder, 100-240 VAC, 50/60 Hz. • Set peak pressure range anywhere between 10-50 cmH2O Accessories: • Reduces animal mortality and lung damage ST1 73-4336 Ball Holder to MicroVent, MiniVent and MidiVent • Continuous pressure measurement during ventilation ST1 73-4337 Bar with magnetic ball for positioning and mounting the actuator head • Pressure is released by an overpressure valve ST1 73-0566 Plexiglas Block Clamp for mounting bar with magnetic • Analog pressure signal output to record with DAQ ball on lab stand software and TTL output of valve status ST1 73-0500 Lab stand with Triangular Base Plate (one block clamp included) • Audible alarm VENTILATORS The HSE-HA Pressure Monitor and Limiter is placed between the ventilator and animal. Excessive pressures are released by an overpressure valve, protecting the ventilator and animal. It is an ideal control tool for controlling pressure on mechanical ventilators, such as MicoVent, MiniVent, MidiVent, Model 687 and Model 683.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 189

* Time to First Mortality (min) - 90 90 120 - - 60 90 www.harvardapparatus.com sodium nitrite. 2 web Mortality (%) 0 43 43 25 0 0 83 83 Adjustable from 30 to 750 cc/stroke. Note that 30 to 750 Adjustable from crank and is made on the the volume adjustment volume adjustmentstherefore accurate while ventilator is running cannot be made while the 7 to 50 strokes/min Adjustable from running ventilator is of a single stroke cycleAdjustable from 25 to 50% the pump is in operation continuously variable while n 10 7 14 8 6 7 6 6 ) groups were given intravenous sodium nitrite 20 min high tidal volume; L-NAME N-nitro-L-arginine methyl 2 115 VAC, 60 Hz Ventilator, Model 613A, Large Animal Volume Controlled 230 VAC, 50 Hz Ventilator Overhaul Kit for Large Animal Product Ventilator, Model 613, Large Animal Volume Controlled (0.25) (2.5) (25) (2.5) + (2.5) (2.5) + 2 2 2 2 2 2 low tidal volume; NaNO - 2-(4-carboxyphenyl)-4,5dihydro-4,4,5,5-tetramethyl-1H-imidazo Overhaul kit does not include cylinder. Overhaul kit does not include

+ NaNO + NaNO + NaNO + NaNO + NaNO + NaNO T T T T T T T LVT HV Table 1 - Mortality Table Group L-NAME HV HV HV HV HV C-PTIO HV Allopurinol Specifications Volume Rate Phase ST1 55-0723 ST1 55-0731 # Order ST1 55-0715 Sodium Pentobarbital continuously infused, Anesthesia: Sodium Pentobarbital continuously infused, see page 131 for infusion pumps. Temperature Control: Heating pad, heat lamp and rectal systems. thermometer, see pages 58 for Homeothermic page 186 and see Ventilator: Inspira ASVp ST1 55-7059, Tracheotomy Cannula, see pages 193. and Vital Signs: Respired gasses, see pages 206 for Gas Monitors Blood Pressure: See pages 209-223. Mortality of all groups. Animals in the LVT group underwent low tidal volume ventilation (6 ml/KG) only. Animals in the HVT group were subjected to ventilator-induced lung injury without further treatment. Animals in the HVT sodium nitrite (NaNO prior to ventilator induced lung injury (dose given in mol/kg in parenthesis). Mortality rate is expressed as percentage of animals dead at 200 min. Time to first mortality is given in minutes survived closest to next measured time-point. C-PTIO lyl-1-oxy-3oxide; HVT ester; LVT *Note: 

O PEEP) 2 [email protected] plus allopurinol 2 email O PEEP). During the HVT paradigm

2 1-508-893-8999 O; 0 cmH 2 plus the nitric oxide synthase inhibitor L-NAME Scan this QR code to view the article: 2 alone the HVT paradigm mortality dropped to zero 2 To order call Harvard Apparatus Spotlight On: Ventilator-Induced Lung Damage Ventilator-Induced Spotlight On: Apparatus Harvard ), NaNO 2 For animals from 1.5 to 50 kg (3.3 to 110 lbs) For animals from 1.5 cc/stroke 30 to 750 Volume adjustable from while running Variable Inspiratory: Expiratory ratio -nitro-L-arginine-methyl-ester and NaNO ω • • •

which is a xanthine oxidoreductase inhibitor meant to test XOR importance. The LVT paradigm served as the control for the experiment and resulted in no injury to subject lungs. The mortality rate and non-treated HVT paradigm resulted in a 43% histological assessment showed that it caused hemorrhagic alveolar edema and atelectasis formation. In animals treated with NaNO Lung Injury in Rats Ventilator-induced Pickerodt, P.A.; Emery, M.J., Zarndt, R., Martin, W., Francis, R.C.E., Pickerodt, P.A.; Emery, M.J., Zarndt, R., Martin, Anesthesiology, Vol. Boemke, W., and Swenson, E.R. (2012) 117(3): 592-601. Equipment Featured: Inspira ASVp ST1 55-7059 Summary: wanted to test the protective effects Pickerodt, et. al., (2012) lung injury (VILI). of Sodium Nitrite during ventilator induced a low injury The researchers used two ventilator paradigms: 2cmH low volume ventilation paradigm (LVT=6 ml/kg; Mitigates Article: Sodium Nitrite Featured the researchers tested the administration of Sodium Nitrite (NaNO and the histology showed some edema, but the lungs were comparable to the low volume controls (Table 1). This paper shows that there is a protective effect of Sodium Nitrite and it is dependent upon XOR and nitric oxide synthases. (N and a high injury high volume paradigm (HVT=peak inspiratory and a high injury high volume paradigm (HVT=peak cmH pressure = 35

Model 613 Animal Ventilators, Large VENTILATORS VENTILATORS

VENTILATORS 190 NEBULIZERS

Power supply To Nebulizer

Nebulizer Control Timer Unit

Ultrasonic Aerosol Nebulizer shown Nebulizer System with Low Dead Volume Adapter • Nebulizer does not alter formulation’s molecular integrity • High quality aerosol, precise particle size 2.5 to 4 µm • Low flow rate approximately Harvard Apparatus Spotlight On: Ventilator-Induced Lung Damage Aerosol Nebulizer 0.1 ml/min • Low residual volume <0.2 ml • Low Particle sizes (100% when particles are below 10 µm) • Nebulized substance does not • No solution warming required contaminate the inspiration path • Ideal for nebulizing drugs sensitive to of the ventilator ultrasonic cavitation • Suitable for rats, guinea pigs or rabbits • Aerosol is automatically transported by compressed air • Low dead volume adapter keeps system compliance • Connecting block required to attach Nebulizer to HSE-HA to 1.5 ml single/double chamber plethysmograph or mouse • System does not exceed 30˚C after 15 min of use plethysmograph • System includes Nebulizer, filler cap, control and timing • Multigas Inlet Adapter (ST1 73-2919) required for use with unit with power supply, and low dead volume adapter MicroVent, MiniVent, or MidiVent1 • Available with Multi-Gas Adapter Kit for Chamber/Box use Order # Product ST1 73-3948 Ultrasonic Aerosol Nebulizer System Size Micron Below Band in Micron % in Band Replacement Parts: 10.5 100 13.6 to 10.5 0 VENTILATORS ST1 73-3732 Ultrasonic Nebulizer with Filler Cap 8.19 99.7 10.5 to 8.19 0.2 ST1 73-3733 Ulrasonic Nebulizer Control Unit with Power Supply and Timer 6.37 98 8.19 to 6.37 1.7 ST1 73-3734 Low Dead Volume Adapter for Nebulizer 4.97 92.2 6.37 to 4.97 5.8 3.88 80.9 4.97 to 3.88 11.3 3.04 68.3 3.88 to 3.04 12.6 2.40 61.5 3.04 to 2.40 6.8 1.90 57.7 2.40 to 1.90 3.8 1.52 54.5 1.90 to 1.52 3.2 1.22 52 1.52 to 1.22 2.5 1.22 to 0 52.0

Order # Product ST1 73-1963 Aerosol Nebulizer ST1 73-3433 Aerosol Nebulizer with Multi-Gas Adapter Kit for Chamber/Box Use1 ST1 73-2919 Multi-Gas Inlet Adapter for MicroVent, MiniVent and MidiVent, see page 187 ST1 73-3300 Tubing Connection Kit for Aerosol Nebulizer

�Note: To use this kit with a Ventilator, the ST1 73-3077 Connection Kit is required.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 191 www.harvardapparatus.com web Product Anesthesia Connection Kit for Inspira and 683 Ventilators MidiVentAnesthesia Connection Kit for MicoVent, MiniVent, Ventilators and 687 Directly connect anesthesia to ventilator for Directly connect anesthesia to ventilator appropriate delivery to intubated or tracheotomized animal preventing Removes pressurized gas to waste port lung and ventilator damage -  -  - Inspira Advanced Safety Ventilator, see page 186 - Inspira Advanced Safety Ventilator, see page 187 - Model 683 Small Animal Ventilator, see Mouse Ventilator, see page 187 - Model 687 page 187 - MicroVent Prenatal Mouse Ventilator, see - MiniVent Mouse Ventilator, see page 188 - MidiVent Mouse Ventilator, see page 188 Necessary for connection of your small animal ventilator Necessary for connection of your small animal to anesthesia system 2 Sizes available to work with: • • # Order ST1 73-3076 ST1 73-3077 Kit Connection Anesthesia [email protected] email ID 2.5 mm (0.10 in) 3.0 mm (0.12 in) 3.5 mm (0.14 in) 4.0 mm (0.16 in) 4.5 mm (0.18 in) 1-508-893-8999 OD 3.36 mm (0.13 in) 4.0 mm (0.16 in) 4.7 mm (0.19 in) 5.3 mm (0.21 in) in) 6.0 mm (0.24 15 mm Endotracheal Tube Connector Kit Product Anesthesia Ventilation Adaptation Kit To order call Uncuffed (cuffed available, please call) Graduated radiopaque PVC tubing Suitable for oral or nasal intubation Supplied sterile in boxes of 10 Endotracheal Tube Connector Kit available for easy connection to ventilators Large Animal Endotracheal tubes available (please call) Adapter and rebreathing bag to assuage over and Adapter and rebreathing bag to assuage underpressures when using a ventilator cc re-breathing bag, 500 Includes: ST1 34-1053 adapter with ST1 34-1081 Venturi style 22 mm scavenge 23-22 mm adapter, ST1 10-1382 side-arm, ST1 10-1354 34-0825 tubing T-piece, ST1 34-0400 tube mount and ST1 • • • • • • • •

# Order ST1 59-9070 ST1 59-9071 ST1 59-9072 ST1 59-9073 ST1 59-9074 Accessories: ST1 72-8331 # Order ST1 34-1389 Tubes Endotracheal VENTILATOR ACCESSORIES ACCESSORIES VENTILATOR Kit Adaptation Ventilation Anesthesia

VENTILATORS 192 VENTILATOR ACCESSORIES

Length Tracheal Cannula Length Intubation Cannula with Y-Adapter with Y-Adapter

Tracheal Cannula with Luer Adapter Intubation Cannula Only

Length Length Length Length

Tracheal Cannula Only Intubation Cannula with Luer Adapter

Tracheal Cannulae Intubation Cannulae

The tracheal cannula is used in a tracheotomy for general The intubation cannula is used in chronic studies where the animal ventilation or respiratory mechanics studies. The outside diameter will be intubated. The outside diameter of the cannula must ensure of the cannula must ensure a tight fit to the inside diameter of the a tight fit to the animal’s trachea. These cannulae are also available animal’s trachea. The cannulae are available in 3 versions: in the 3 versions. • Cannula only, for your own assembly • Cannula only, for your own assembly • With Y-adapter for connecting to a ventilator, the outside • With Y-adapter for connecting to a ventilator, the outside diameter of the Y-adapter matches to most of the ports diameter of the Y-adapter matches to most of the ports diameter of the ventilators. diameter of the ventilators. • Luer-adapter for use with any Luer style connections, • Luer-adapter for use with any Luer style connections, such as the Y-Luer Adapters described below. such as the Y-Luer Adapters described below.

Tracheotomy Cannulae Intubation Cannulae OD Cannula with with Luer Cannula with with Luer (mm) Animal Only Length Y-Adapter Length Adapter Length Only Length Y-Adapter Length Adapter Length 1.0 mouse ST1 73-0029 15 ST1 73-2731* 13 ST1 73-2835 8 ST1 73-0030 28 ST1 73-2737* 24 ST1 73-2848 26 1.1 mouse – – – – – – ST1 73-2838 28 ST1 73-2843* 24 ST1 73-2849 26 1.2 mouse ST1 73-2825 15 ST1 73-2830* 13 ST1 73-2836 8 ST1 73-2839 30 ST1 73-2844* 27 ST1 73-2850 27 1.3 mouse ST1 73-0028 15 ST1 73-2730* 13 ST1 73-2837 9 – – – – – – 1.5 small rat ST1 73-2826 20 ST1 73-4112+ 15 ST1 73-2729 10 ST1 73-2840 37 ST1 73-4115+ 32 ST1 73-2851 32 1.8 small rat ST1 73-2827 20 ST1 73-4113+ 15 ST1 73-2728 13 ST1 73-2841 40 ST1 73-4116+ 35 ST1 73-2852 35 2.0 small rat ST1 73-2828 25 ST1 73-4114+ 20 ST1 73-2727 13 ST1 73-0038 50 ST1 73-4117+ 45 ST1 73-2853 45 2.3 rat/guinea pig ST1 73-2829 25 ST1 73-2834# 20 ST1 73-2726 14 ST1 73-2842 50 ST1 73-2847# 45 ST1 73-2854 45 2.5 rat/guinea pig ST1 73-0033 25 ST1 73-2732# 20 ST1 73-2725 17 ST1 73-0039 50 ST1 73-2739# 45 ST1 73-2855 45 3.0 rat/guinea pig ST1 73-0034 25 ST1 73-2733# 20 ST1 73-2724 20 ST1 73-0040 60 ST1 73-2740# 53 ST1 73-2856 53 3.5 rat/guinea pig ST1 73-0035 30 ST1 73-2734# 25 ST1 73-2723 24 ST1 73-0041 63 ST1 73-2741# 56 ST1 73-3112 56 4.0 rabbit ST1 73-0036 32 ST1 73-2735§ 25 – – – – – – – – 4.0 rabbit – – – – – – ST1 73-0042 74 ST1 73-0042§ 62 – – VENTILATORS 4.0 rabbit ST1 73-0037 35 ST1 73-2736§ 30 – – – – – – – – 4.0 rabbit ST1 73-3319 40 ST1 73-2819§ 30 – – – – – – – –

* Micro Y-adapter for Minivent and MicroVent, for tubing ID 1.5 to 2.2 mm + Miniature Y-adapter, for tubing ID 2.5 to 3.4 mm # Medium Y-adapter, for tubing ID 6 to 7.4 mm § Large Y-adapter, for tubing ID 7 to 10 mm

Y-Luer Adapters Order # Product ST1 73-4118 Adapter for Luer cannulae with Miniature Y-adapter for tubing ID 1.5 to 2.2 mm (e.g. MicroVent & MiniVent) ST1 73-4121 Adapter for Luer cannulae with Y-adapter for tubing ID 2.5 to 3.4 mm (e.g. MidiVent) ST1 73-4122 Adapter for Luer cannulae with Y-adapter for tubing ID 3.3 to 4.6 mm ST1 73-4123 Adapter for Luer cannulae with Y-adapter for tubing ID 4.1 to 4.9 mm ST1 73-4065 Adapter for Luer cannulae with medium Y-adapter for tubing Y-Luer Adapter ID 6 to 7.4 mm

These Y-Luer Adapters are for use in general ventilation or respiratory mechanics studies. Five sizes available.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 193 VENTILATOR ACCESSORIES

Fiber Optic Stylet (FOS) Fiber Optic Stylet inserted into coupling adapter

Lung Inflation Bulb Illuminator (Shown with Endotracheal Tube)

Fiber Optic Stylet illuminated

Small Animal Intubation Kits Lung Inflation Bulb

• Three kits available depending on your animal size • Safe and reliable method for verification of endotracheal • Intubation kits supplied with: Fiber optic stylet size tube placement dependent on kit ordered, endotracheal tubes (pkg. of 5) - Squeezing bulb creates obvious distension of chest size dependent on kit ordered, illuminator and when endotracheal tube is placed properly

VENTILATORS carrying case • Reduces time off ventilator • Reduces animal distress Order # Product • Distal end is a male Luer that mates with female Luer ST1 72-9085 Mouse Intubation Kit connector on endotracheal tube ST1 72-9086 Small Rat Intubation Kit • Semi-disposable as needed ST1 72-9087 Large Rat Intubation Kit ST1 72-9088 Stylet Kit - includes one of each stylet, illuminator and Order # Product carrying case ST1 72-9083 Lung Inflation Bulb, pkg. of 3 ST1 72-9089 Complete Kit - includes one of each stylet, each size of endotracheal tube (pkg. of 5 for each size), illuminator ST1 72-9084 Lung Inflation Bulb, box of 50

Fiber Optic Stylet (FOS) Small Animal Endotracheal Tubes

• Fiber optic light allows greater visibility during intubation • Flexible design minimizes trauma procedure • Urethane IV Catheter • Semi-rigid guidance for intubation of small animals • Available in two sizes • Illumination end is stripped and reinforced fiber optic wire and inserted into trachea through IV catheters Order # Product • Coupling adapter is included to couple the IV catheters to ST1 72-9079 Endotracheal Tube 20 ga x 1" for Mice, pkg. of 5 the FOS ST1 72-9080 Endotracheal Tube 20 ga x 1" for Mice, pkg. of 50 ST1 72-9081 Endotracheal Tube 16 ga x 1.25" for Rats, pkg. of 5 Order # Description Weight Range Catheter Sizes ST1 72-9082 Endotracheal Tube 16 ga x 1.25" for Rats, pkg. of 50 ST1 72-9075 Stylet for Mice 10+ g 10-20 g-22 ga (1.0 in) 20+ g-22 ga (1.0 in) ST1 72-9076 Stylet for Rats 100-200 g 18 ga (1.25 in) ST1 72-9077 Stylet for Rats 200-300+ g 200-300 g-16 ga (1.25 in) 300+g-14 ga (1.5 in) ST1 72-9078 Illuminator for Fiber Optic Stylets

194 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com VENTILATOR ACCESSORIES

Fiber Optic Laryngoscope Blades

Inside Length ST1 59-6569 Order # Size Overall Length (Base to Tip) Miller Fiber Optic Laryngoscope Set MacIntosh Laryngoscope Blades: ST1 59-6559 1 89 mm (3.5 in) 63 mm (2.4 in) ST1 59-6560 2 108 mm (4.3 in) 82 mm (3.2 in) ST1 59-6561 3 126 mm (4.9 in) 101 mm (3.9 in) ST1 59-6562 4 160 mm (6.3 in) 135 mm (5.3 in) Miller Laryngoscope Blades: ST1 72-6390 00 8 mm (0.32 in) 36 mm (1.42 in) ST1 59-6564 0 8 mm (0.32 in) 53 mm (2.0 in) ST1 59-6565 1 8 mm (0.32 in) 79 mm (3.1 in) ST1 59-6566 2 79 mm (3.1 in) 132 mm (5.2 in) ST1 59-6567 3 11 mm (0.4 in) 172 mm (6.8 in) ST1 59-6568 4 13 mm (0.5 in) 182 mm (7.2 in)

Laryngoscope Handles for Fiber Optic Blades

• Available with disposable batteries or rechargeable 2.5 V ST1 59-6563 nickel-cadmium battery (batteries supplied with handles) MacIntosh Fiber Optic • Disposable battery styles come in two sizes Laryngoscope Set - AA Penlight, Small - C, Medium • Rechargeable is available in medium size only Fiber Optic Laryngoscope Sets • Recharger base can hold two handles and is sold separately • Removable fiber optic light pipe for easy cleaning and quick replacement Order # Product • Durable one-piece stainless steel construction; knurled ST1 59-6572 Laryngoscope Handle, Small with Disposable Battery finish for positive grip (AA Penlight) • Brilliant halogen illumination provides twice the light ST1 59-6571 Laryngoscope Handle, Medium with Disposable Battery (C) intensity of ordinary laryngoscope lamps ST1 59-6718 Laryngoscope Handle, Medium with Rechargeable Battery • Wireless blades eliminate electrical contact ST1 59-6719 Recharger Base, 115 VAC, 60 Hz • MacIntosh and Miller style fiber optic blades available ST1 59-6721 Replacement 2.5 V Nickel-Cadmium Battery ST1 59-6570 Replacement Halogen Lamp for ST1 59-6572, ST1 59-6571 and ST1 59-6718 Laryngoscope Handles, pkg. of 1 Miller Fiber Optic Laryngoscope Set VENTILATORS

• Includes 5 Miller laryngoscope blades from 0-4 with small and medium handle, with zippered case

Order # Product ST1 59-6569 Miller Fiber Optic Laryngoscope Set

MacIntosh Fiber Optic Laryngoscope Set

• Includes 4 MacIntosh laryngoscope blades with a small and medium handle, with zippered case

Order # Product ST1 59-6563 MacIntosh Fiber Optic Laryngoscope Set

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 195 VENTILATOR ACCESSORIES

Tracheal Cannulae

A tracheal cannula is the most common method of connecting an animal to a ventilator. This ‘Vee’ form tracheal cannula is normally preferred because it minimizes air/gas ‘dead space’. This tracheal cannula consists of two parts which are offered separately: a cannula vee and a cannula nozzle. The cannula vee is offered in two sizes, small and large. The nozzles are available in various sizes. They screw onto the vee, and a neoprene O-ring seals the joint. For tracheal cannula selection there are two basic considerations: • The outside diameter of the cannula vee must Intubation Platform approximately match the outside diameter of the ports of the ventilator to ensure a tight fit of Harvard Apparatus specifically designed this intubation platform the tubing. to allow the optimal insertion of tracheal cannulae prior to artificial ventilation. The intubation platform comes with an adjustable • The outside diameter of the nozzle of the cannula must incisor noose, to allow your subject to be hung from their front VENTILATORS ensure a tight fit to the inside diameter of the animal’s teeth, the incline of the board can then be adjusted to the optimal trachea. angle to allow you to see the correct placement of These tracheal cannulae are constructed of heavily nickel-plated the cannulae. brass. The cannula vees and cannula nozzles must be ordered The intubation platform is available in 3 different models from mice separately. up to large rats with the angle being fully adjustable and locked into place by a simple thumb screw. Order # Product ST1 50-3359 Small Cannula Vee, 6.5 mm OD Dimensions ST1 50-3367 Large Cannula Vee, 16 mm OD Order # Product of Platform ST1 50-3177 Small Cannula Nozzle, 2 mm OD* ST1 34-1415 Intubation Platform for Mouse 130 x 50 mm (5.1 x 2 in) ST1 50-3193 Small Cannula Nozzle, 3 mm OD* ST1 34-1416 Intubation Platform for Small Rat 200 x 100 mm (7.9 x 9.3 in) ST1 50-3219 Small Cannula Nozzle, 4 mm OD* ST1 34-1417 Intubation Platform for Large Rat 300 x 150 mm (11.8 x 5.9 in) ST1 50-3235 Small Cannula Nozzle, 5 mm OD* ST1 50-3250 Small Cannula Nozzle, 6 mm OD* ST1 50-3284 Large Cannula Nozzle, 6 mm OD** ST1 50-3300 Large Cannula Nozzle, 8 mm OD** ST1 50-3326 Large Cannula Nozzle, 11 mm OD** ST1 50-3342 Large Cannula Nozzle, 14 mm OD**

*Note: For use with ST1 50-3359. **Note: For use with ST1 50-3367.

196 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com VITAL SIGNS

Vital signs monitoring is required for veterinary and large animal surgeries in order to ensure the best surgical outcome, but is just as important in small animal surgeries. Harvard Apparatus offers a wide variety of equipment which enables the monitoring and recording of vital signs for small and large animals, providing a means to ensure subjects stay within normal physiological parameters.

Vital signs monitoring of the cardiopulmonary system reflects not only the health of the animal but the depth of anesthesia. Historical methods for small animals include reflex monitoring, which is crude and not always appropriate; for instance, the use of paralytics invalidates the toe pinch method. Traditional vital signs include blood pressure (invasive or

non-invasive), end-tidal carbon dioxide (ETCO2), arterial blood oxygen saturation (SaO2), ECG, heart rate, respiration rate and temperature. Combining the vital signs monitors with data acquisition adds a new level of data preservation and analytics that any lab can appreciate.

PRODUCT PAGE

Powerlab Systems and LabChart Modules...... 198-201 NEW Pulse Oximetry...... 202-205 Capnography...... 206-208 Blood Pressure...... 209-223 NEW Invasive Blood Pressure Transducers...... 209-213, 228 Millar Pressure Transducers...... 214-216 Amplifiers & Cases...... 217-218 Electronic and Manual Pressure Calibrators...... 219 Non-Invasive Blood Pressure...... 220-223 NEW Build-Your-Own Physiological Monitoring Systems...... 224-230 Blood Flow, Blood Pressure & ECG Systems...... 224-226 Blood Flow Transducers...... 227 Blood Pressure Transducers ...... 209-213, 228 ECG Electrodes & Accessories...... 229-230 VITAL SIGNS VITAL VITAL SIGNS

197 VITAL SIGNS

Research Surgical Monitoring Suites Powered by PowerLab®!

Still logging vital signs in a lab notebook? Who has time to manually enter all of their data into analysis software? Powerful research surgical monitoring systems can be built around the PowerLab® Data Acquisition System with LabChart software. Harvard Apparatus provides a wide variety of surgical monitors featuring analog data output, allowing all of your surgical and research data to be recorded right into your computer. VITAL SIGNS VITAL

198 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com VITAL SIGNS MONITORING & CONTROL

Specifications (subject to change) Analog Inputs: Number of Inputs 4, 8 or 16 channels Input Configuration: 4 Inputs PL3504 4 single ended or 4 differential Pod and 4 single ended 8 Inputs PL3508 4 dedicated single ended inputs, 4 input configurable as single-ended or differential (through Pod port) 16 Inputs PL3516 12 dedicated single ended inputs; 4 inputs configurable as single ended or differential (through Pod port) Amplification Range ±2 mV to ±10 V full scale in 12 steps Maximum Input Voltage ±15 V Sampling: ADC Resolution 16 bit (313 µV resolution on 10 V range) Linearity Error 2.5 LSB (from 0 to 70°C) PowerLab® Maximum 200 kHz on one or two inputs Sampling Rates Whether you are simply using the system to ensure that all animals 100 kHz on 3 or 4 inputs are within safe physiological parameters during a procedure or you 40 kHz on 5 to 8 inputs are collecting your data as part of your research protocol, 20 kHz on 9 to 16 inputs the PowerLab® system is your answer. With a proven track record in Analog Outputs: thousands of research institutes, universities, research hospitals and Quantity Number of outputs 2 commercial laboratories worldwide, you cannot go wrong. Output Single-ended (outputs can be used as one Configuration differential output) LabChart™ Output Range ±200 mV to ±10 V full scale in six steps Output Resolution 16 bit (313 µV resolution on 10 V range) Intuitive and powerful software allows researchers to concentrate External Trigger: on the science. With no programming required, the software is Mode TTL level (isolated) or contact closure mastered quickly and provides comprehensive recording, display (non-isolated) and analysis features. Digital Output 8 independent lines, TTL output level (8 mA maximum load per line)

® Digital Input 8 independent lines, TTL input level, threshold 1.2 The PowerLab Advantage V, 10 kΩ input impedance, 5 V maximum Physical Configuration: PowerLab® Data Acquisition Systems are complete data acquisition Dimensions, 70 x 240 x 260 mm (2.6 x 9.5 x 10.2 in) and analysis solutions for academic institutions, government H x W x D organizations and private industry. Supplied with LabChart™ and Weight 2.7 kg (5.95 lbs) Scope™ software, PowerLab® systems offer comprehensive data Operating Voltage 90 to 250 V (automatic) recording, display and analysis features for a wide variety of research applications. Maximum Power 90 VA (full complement of Front-ends and Pods) Needs Around the PowerLab® system we provide a range of amplifiers, Operating 5 to 35°C, 0 to 90% humidity (non-condensing) instruments and specialized analysis software to provide a complete Temperature research solution.

Order # Product VITAL SIGNS Computer System Compatibility ST1 77-0239 PL3504 PowerLab 4/35 – 4 Channels with LabChart Software Windows 8 (32-bit and 64-bit editions) (7.3.7 or later) with .NET ST1 77-0241 PL3508 PowerLab 8/35 – 3.5 SP1, or Windows 7 (32-bit and 64-bit editions) (7.0.3 or later), 8 Channels with LabChart Software Windows Vista SP1 (32-bit and 64-bit editions) or Windows XP SP2 ST1 77-0243 PL3516 PowerLab 16/35 – or later with .NET 2.0 SP2 or .NET 3.5 SP1 16 Channels with LabChart Software ST1 77-0240 PL3504/P PowerLab 4/35 – 4 Channels with LabChart Pro Software All PowerLab Data Acquisition Systems ST1 77-0242 PL3508/P PowerLab 8/35 – are Supplied with 8 Channels with LabChart Pro Software ST1 77-0244 PL3516 PowerLab 16/35 – • LabChart or LabChart Pro software 16 Channels with LabChart Pro Software • Cable kit including power cord, BNC to BNC test cable, USB cable

• Finger pulse transducer Powerlab is a registered trademark of ADInstruments, Inc. LabChart is a trademark of ADInstruments, Inc.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 199 VITAL SIGNS MONITORING & CONTROL

LabChart™ Software Blood Pressure Module

LabChart™ is suitable for research on any species – from humans to mice to flies. The software provides the capability to continuously record and display up to 16 channels of data, perform online or offline calculations, display numerous analysis windows and automatically extract data. Quick and easy set up of experimental parameters, powerful computation and analysis features are just the beginning. Configuring recording parameters, such as range and filters, takes seconds, with all of the information, including settings, calibrations and computed values, saved in a single file. Parameters of interest are easily extracted to an internal spreadsheet and can be exported for further analysis or graphing. LabChart™ Modules The Blood Pressure module for Windows automatically detects, LabChart™ modules are software add-ons that provide analyzes and reports a set of cardiovascular parameters from arterial comprehensive analysis feature sets for specific research or ventricular pressure signals, either online or offline. This module applications. For the latest list of modules see the software is ideal for in vivo applications such as invasive blood pressure updates section of our website. (arterial) monitoring where parameters such as systolic and diastolic Especially relevant to the surgical suite are the advanced analysis pressure, dicrotic notch, heart rate, time to peak, pulse pressure, modules for ECG, blood pressure, cardiac output, and video ejection duration, and mean arterial pressure are of interest. capture. Other modules of interest are the Dose Response module Also popular is left ventricular pressure measurement for both as well as the PV Loop Analysis module. in vivo and ex vivo applications. Easily compute parameters such All modules are available for individual purchase (for use with the as End Diastolic Pressure (EDP), maximum dP/dt, maximum latest LabChart software) or as part of LabChart Pro. The LabChart pressure, minimum dP/dt, minimum pressure, Tau, systolic & Pro software package includes all LabChart modules and includes diastolic duration, cyclic duration, heart rate, max and min dP/dt, free LabChart version upgrades and new modules for 5 years. contractility index, and more. Existing LabChart users and PowerLab system purchasers can LabChart also displays parameters calculated by the Blood Pressure upgrade to LabChart Pro at a special price. module as continuous data on separate channels. Raw data is unaltered by any calculation ensuring recorded ventricular or ECG Analysis Module arterial pressures can be reanalyzed anytime.

Cardiac Output Module VITAL SIGNS VITAL

The ECG Analysis module for Windows automatically detects and reports PQRST onset, amplitude and intervals, either online or offline. Automatic generation of analysis plots from calculated The Cardiac Output module for Windows provides the user with an parameters: analysis tool to easily extract and calculate cardiac output from small • QT/RR Plot (QT Interval versus RR Interval) animals, using the thermodilution technique and recorded in LabChart. • QT/Time Plot Cardiac output (CO) is inversely proportional to the area under the • RR/Time Plot thermodilution curve. The prolongation of the decay curve due to recirculation of the injectate is taken into account for calculations. • Waterfall Plot The Cardiac Output module window plots temperature recorded by The raw data is unaltered by any calculations to ensure that the LabChart versus time to give a thermodilution curve, and is able to ECG can be reanalyzed. Default detection and analysis parameters calculate both upwardly- and downwardly-displayed thermodilution are included for human, pig, dog, rabbit, guinea pig, rat and curves. Analysis of recordings in the duration of 5 seconds to 10 mice ECG. Detection settings can be customized at any time for minutes is possible to cover a range from small to large animals. optimization or for use with other animals. CO is displayed in mL/min. Advanced analysis provides an accurate baseline, compensating for drift if desired. 200 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com VITAL SIGNS MONITORING & CONTROL

Video Capture Module PV Loop 2 Module

The Video Capture module (available for Macintosh and Windows) PV Loop for LabChart is specifically designed for the analysis of is used for simultaneous recording and synchronization of a video in vivo ventricular pressure-volume data in small and large (Windows Media or Quicktime) and a LabChart data file. It allows mammals, or ex vivo, using Working Heart systems. the user to record a movie directly to computer using a personal As of version 2.0, PV Loop supports the new streamlined Workflow video camera. The movie is then saved and linked to the LabChart Mode, simplifying the process of calibration through to final data file. analysis. Recorded movie and LabChart data files can be played back In the new Workflow mode, calibration procedures are streamlined, together allowing users to observe what is happening in the movie allowing for a more efficient progression through to data analysis. simultaneously with any point in the recorded data, or vice versa. Small and large animal PV analyses utilize subtly different calibration regimes. With PV Loop, small and large mammal presets Dose Response Module are available which automatically reconfigure the Workflow mode. Factors such as temperature and catheter insertion angle can introduce unwanted variability and affect volume estimate precision. The solution to this is to sample conductance values multiple times from each cuvette well. PV Loop makes this easy with its intuitive new cuvette calibration view. Estimating parallel conductance (Vp) from the end diastolic volume and end systolic volume regression slope from a single saline bolus infusion can lead to inaccuracy. For this reason, Vp from multiple saline bolus infusions are averaged. PV Loop supports this using an intuitive interface within Workflow mode. Alpha calibration is a linear correction to the volume data that adjusts for any other discrepancies in volume that are not taken into account by the previous calibration steps. PV Loop supports the calculation of alpha using an independent measure The Dose Response module for LabChart (Windows) allows of stroke volume, or cardiac output. See the Blood Flow and for the calculation of dose response type data from LabChart Pressure Surgical Monitoring option on pages 224-230, one way recordings from both in vivo and ex vivo applications. Analysis to independently measure CO (e.g. for ex vivo applications). The can be performed automatically or manually in real time or offline. thermodilution method is also an available option.

Previously recorded LabChart data can be converted for use in the VITAL SIGNS Dose Response module. The results of the analysis can be exported The new PV Loop 2 Module provides all industry standard for use by other applications. parameters such as stroke work, cardiac output, ejection fraction, Tau, isovolumic relaxation constant, and many more. The Dose Response module identifies response markers in the LabChart recording and uses the selected data to generate dose response curves and calculated values such as EC50 and Hill slopes. Order # Product Automatic and manual display of single or multiple dose response ST1 77-0215 ECG Analysis Module curve calculation modes are possible. ST1 77-0214 Blood Pressure Module ST1 77-0218 Cardiac Output Module ST1 77-0221 Video Capture Module ST1 77-0212 Dose Response Module ST1 77-0259 PV Loop 2 Module

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 201 PULSE OXIMETRY

PULSE OXIMETRY

Pulse oximetry measures arterial blood oxygen saturation levels (SaO2%). This is accomplished by looking at the relative absorptions of red and infared lights. The differential absorptions correspond to the ratio of oxyhaemoglobin to deoxyhaemoglobin (Alexander, Teller and Gross, 1989). Pulse oximetry is the most common vital signs monitor and is used to pick up problems in anesthesia such as hypoventilation, airway obstructions and equipment related problems. We now offer the only pulse oximetry system in the world that can be used on mice with heart rates over 400 BPM!

Specifications

Oxygen Saturation (SaO2): Range 0 to 100% Arterial Blood Oxygen Saturation Resolution <1.5% across entire measurement range Response Reported after every heartbeat -- screen refreshed Time every 0.72 seconds Pulse Rate (BPM): Range 90 to 900 BPM Pulse Rate (BPM) Resolution (BPM) 210 2.4 300 4.9 400 8.7 500 13.5 600 19.4 700 26.2 800 34 MouseOxPlus® Pulse Oximeter for Rodents 900 42.9 Response Reported after every heartbeat -- screen refreshed This non-invasive pulse oximeter is designed to work with neonatal Time every 0.72 seconds mice through adult rats. It has a patented design to detect heart Breath Rate (BrPM): rates of 90-900 bpm. The MouseOxPlus® easily allows researchers Range 25 to 450 BrPM to titrate mechanical ventilation and monitor depth of anesthesia. Breath Rate (BrPM) Resolution (BrPM) • MRI Compatible1 25 0.1 100 0.6 • Multiple subject monitoring2 200 2.2 • Provides the following measurements: 300 4.9 Arterial Oxygen Saturation 400 8.7 Heart Rate Response Reported every 1.7 seconds and is a moving average Breath Rate Time of the rate of breathing for the previous 10 breath rate Temperature (optional) measurements. The screen updates every 0.72 seconds, VITAL SIGNS VITAL Pulse Distention but new breath rate data is presented at the lower rate. Breath Distention Pulse Distension: Activity (optional) Range 0 to 800 mm Software Resolution <2.4% of measurement Response Reported after every heartbeat — screen refreshed • Standard software is included with all MouseOxPlus® Time every 0.72 seconds oximeters. It includes basic monitoring and Breath Distension: parameters alarms for all vital signs measured by the Range 0 to 800 mm MouseOxPlus®. Resolution <2.4% of measurement • Premium monitoring with data analysis is included Response Reported every 1.7 seconds with item ST1 72-8018 and ST1 72-8019, or available Time as an upgrade. It enables trending charts, real time Temperature Range 15° to 50°C recording options, event/file markers, and quick Resolution ±0.1 °C averaging for feature checking. Response Time Reported every 0.72 seconds • Conscious Monitoring module enables the MouseOxPlus® to lock onto freely moving subjects and provides general activity level information. • Temperature module. For unconscious subjects only. • MRI module MouseOx and MouseOxPlus are registered trademarks of Starr Life Sciences. ThroatClip, STARR-link and CollarClip are trademarks of Starr Life Sciences. All MouseOx Plus® systems come with two sensors of your choice.

202 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com PULSE OXIMETRY

Order # Product Collar Clip Premium Bundles ST1 72-8018 MouseOx®Plus Pulse Oximeter for Rodents with Software, 115 VAC, 60 Hz ST1 72-8019 MouseOx®Plus Pulse Oximeter for Rodents with Software, 220 VAC, 50 Hz ST1 72-8020 MouseOx®Plus and Starr-Link, 115 VAC, 60 Hz Mouse Thigh Sensor ST1 72-8021 MouseOx®Plus with Starr-Link, 230 VAC, 50 Hz Standard ST1 72-8010 MouseOx®Plus Pulse Oximeter for Rodents, 115 VAC, 60 Hz Throat Clip Sensor ST1 72-8011 MouseOx®Plus Pulse Oximeter for Rodents, 230 VAC, 50 Hz Additional Upgrades: ST1 72-8012 MouseOx®Plus Application Software ST1 72-8013 MouseOx®Plus Multiplexer 16, 115 VAC3, 60 Hz ST1 72-8014 MouseOx®Plus Multiplexer 16, 230 VAC3, 50 Hz Pulse Oximetry Sensors ST1 72-8083 Multiplexer 8, 115 VAC3, 60 Hz All sensors are for MouseOx®Plus. Please call if you have the previous ST1 72-8084 Multiplexer 8, 230 VAC3, 50 Hz generation MouseOx. ST1 72-8008 Multiplexer 8 with Temperature, 115 VAC3, 60 Hz ST1 72-8009 Multiplexer 8 with Temperature, 230 VAC3, 50 Hz • CollarClip™ is a non-invasive clip for awake-behaving subjects ST1 72-8016 MouseOx® Plus Temperature Module, Sensor • ThroatClip™ is a non-invasive clip for anesthetized subjects and 1.8 m (6 ft) Cable ST1 72-8017 MouseOx® Plus MRI, Temperature Sensor, Software Module and 6.1 m (20 ft) Cable Order # Product ST1 72-8022 STARR-link™ for MouseOx®Plus, 115 VAC, 60 Hz ST1 72-8085 CollarClip™ XS with Blank Clip: Mouse 1 to 15 g, Conscious Mice and Young Rats, pkg. of 5 ST1 72-8023 STARR-link™ for MouseOx®Plus, 230 VAC, 50 Hz ST1 72-8086 CollarClip™ S with Blank Clip: Mouse >15 g, Rat 5 to 30 g, pkg. of 5 ST1 72-8087 CollarClip™ M with Blank Clip: Mouse and Rat 31 to 100 g, pkg. of 5 ST1 72-8088 ThroatClip™ XS with Blank Clip: Mouse 1 to 15 g. Unconcious Mice and Young Rats, pkg. of 5 ST1 72-8089 ThroatClip™ S with Blank Clip: Mouse >15 g, Rat 5 to 30 g, pkg. of 5 ST1 72-8090 ThroatClip™ Mwith Blank Clip: Mouse and Rat 31 to 100 g, pkg. of 5 ST1 72-8091 Mouse Thigh Sensor, pkg. 5 ST1 72-8092 CollarClip™ L with Blank Clip: Rat 101 to 300 g, pkg. of 5 ST1 72-8093 CollarClip™ XL with Blank Clip: Rat 301 to 500 g, pkg. of 5 ST1 72-8094 CollarClip™ 2XL with Blank Clip: Rat >500 g, pkg. of 5 ST1 72-8095 ThroatClip™ L with Blank Clip: Rat 101 to 300 g, pkg. of 5 ST1 72-8096 ThroatClip™ XL with Blank Clip: Rat 301 to 500 g, pkg. of 5 Oxydial Bench Hypoxydial Bench ST1 72-8097 ThroatClip™ 2XL with Blank Clip: Rat >500 g, pkg. of 5 ST1 72-8098 Rat Foot Sensor, pkg. of 5 Gas Blenders ST1 72-9608 Sensor, 0.9 m (3 ft) ST1 72-9609 Sensor, 1.8 m (6 ft) Two gas blenders are available to use to titrate your concentration Module Sensors: of oxygen. The Oxydial and the Hypoxydial allow you to use precise ST1 72-8015 MouseOx®Plus MRI sensor levels of oxygen in your experiment which is important for avoiding VITAL SIGNS ST1 72-8099 Temperature Sensor with 1.8 m (6 ft) Cable oxygen toxicity or to mimic common experimental tests such as the Cables: flu. Both systems come complete with tripod, pressure regulators, ST1 72-9670 1.8 m (6 ft) Universal Connector Cable for CollarClip®/SubQ™ flowmeter, humidifier, and high pressure hoses. Sensors Oxydial ST1 72-9604 USB Cable for MouseOx ST1 72-8080 Universal Cable, 1.8 m (6 ft) • Delivers oxygen concentrations from 0 - 100% ST1 72-8081 Universal Cable, 3.7 m (12 ft) • Utilizes standard nitrogen and oxygen tanks ST1 72-8082 Multiplexer Patch Cable 0.3 m (1 ft) Hypoxydial Replacement Parts: Power Supply for MouseOx® • Delivers oxygen concentrations from 0 - 21% ST1 72-9605 ST1 72-9606 Int’l Power Supply/MouseOx® • Utilizes standard nitrogen and air tanks 1MRI compatible with purchase of MRI module. Order # Product 2Multiple subject monitoring with purchase of a multiplexer. 3Please order item ST1 72-8081 for each subject you intend to use with the ST1 72-9622 Oxydial Mulitplexer. You must order at least one. ST1 72-9698 Hypoxydial

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 203 PULSE OXIMETRY

V3304 Pulse Oximeter with SAC Technology

• Reliably measure SpO2 and pulse rate • Internal rechargeable battery • Easy-to-read LED display with adjustable brightness • Variety of reusable sensors designed for animal applications • Quantitative pulse strength bar • Visual and audible alarm signals • Advanced digital oximetry • 99 patient memory

• Veterinary specific SpO2 sensors to accommodate a variety of species, i.e. rabbits, cats and dogs

Specifications SpO & Pulse Rate 3-digit LED display, 10.9 mm (0.43 in) high V1030 Hand Held Pulse Ox for Large Animals 2 SpO2: • Low perfusion performance Range 0 to 100% Accuracy ±2% at 70 to 100% ±3% at 50 to 69% • Motion tolerance Alarm Range High: 50 to 100% and Off (1% steps) • Pulse amplitude Index (PI) bar-graph indicator to help Low: 50 to 99% and Off (1% steps) identify and maintain a good test site Averaging 4, 8, or 16 pulse beat average • Quick selection of default alarm limit values by patient Pulse Rate: type: cat, dog, horse, factory and custom Range 20 to 350 BPM • Large bright LED display Accuracy ±1 beat or 2% whichever is greater • Memory storage for up to 99 patients Alarm Range High: 5 to 350 BPM and Off (5 BPM steps) • Audible visual alarms Low: 5 to 350 BPM and Off (5 BPM steps) Averaging 8 or 16 sec average • 3 year warranty Battery Life Standard lead-acid battery: Internal rechargeable; • System includes: not user replaceable. Fully charges in about 6 hrs. Approximately 4.5 hrs continuous use. - 1.5 m (5 ft) oximetry extension cable Printer Output SpO2 and pulse rate can be printed every 5 seconds VITAL SIGNS VITAL - Reflectance oximetry sensor (data log). Data saved every 4 to 30 seconds can - Universal “Y” oximetry sensor be printed (trend) analog output (optional) digital - Four AA Alkaline batteries (17 hrs of use) output (optional). Safety Approvals Designed to meet IEC-601-1, CSA 125, UL 544, Order # Product and CE (EMC) ST1 72-3126 V1030 Pulse Oximeter AC Charger Voltage 105 to 125 VAC, 60 Hz, 100 V Requirement Accessories 230 VAC, 50/60 Hz (Optional) ST1 75-0250 Custom Lithium Ion Rechargeable Battery, 30 hrs of use, Dimensions, H x W x D 216 x 82 x 140 mm (3.4 x 8.5 x 5.5 in) 3 hr charge Weight 810 grams (1.8 lbs) ST1 75-0251 Power Supply Universal with US/Japan Adapter 30 Watt, 100-240 VAC, 50 Hz Order # Product ST1 75-0252 Power Supply Universal with International Blades, 30 Watt, 100-240 VAC, 60 Hz ST1 72-3174 V3304 Digital Table Top Pulse Oximeter, 110 VAC, 60 Hz ST1 75-0253 AC Power and Rechargeable Lithium Ion Battery System ST1 72-3264 V3304 Digital Table Top Pulse Oximeter, 220 VAC, 50 Hz ST1 75-0254 AC Power and Rechargeable Lithium Ion Battery System Sensors and Sensor Accessories Optional Accessories (OUS*) ST1 72-3256 Universal “Y” Sensor ST1 72-3179 Printer Interface Cable ST1 75-0255 Universal Mounting Bracket ST1 72-3254 Reflectance Sensor ST1 72-3180 PC Interface Cable ST1 75-0256 Universal Mounting Bracket with IV Pole Clamp ST1 72-3157 Oximetry Cable, ST1 72-3178 Digital Output Adapter ST1 75-0257 Docking Station to convert V1030 to Table-Top Unit 1.5 m (5 ft) ST1 75-0258 Docking Station (OUS*) ST1 72-3163 Oximetry Simulator ST1 72-3177 Analog Output Adapter 1.5 m (5 ft) ST1 72-3175 IV Pole Bracket Note *OUS = Outside US.

204 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com PULSE OXIMETRY

Advisor® Vital Signs Specifications (continued) Monitor Capnography (continued):

N2O Compensation Selectable 40% • Four waveform Averaging 4 breaths color display Flow Rate 150 ml/min �20 ml

• Point and click interface ETCO2 Alarm Range 0-100 mmHg, 0-14 kPa, 0-10% CO2 and Off • View all parameter Respiration Rate: trending information Range 0-150 breaths/min on screen Accuracy �1 breath/min • 2 year warranty Alarm Range 3-120 breaths/min and off • All Advisor models come complete with power cord, 2-Channel IBP: reflectance Y sensor, oximetry extension cable, Measuring Range -50-300 mmHg 3 lead ECG, NIBP cuff set and manual. Accuracy � 1 mmHg or �1%, whichever is greater Alarm Limits -50-300 mmHg The Advisor® Vital Signs Monitor is the leading choice in multi- Pulse Rate: parameter monitoring and is ideal for larger animals such as Range 20-350 bpm cats, dogs, pigs, horses, and non-human primates. It has a large Accuracy �2 bpm or �2% whichever is greater easy-to-read display, intuitive design, and is available in multiple Averaging 8 sec configurations. Standard parameters include ECG, pulse oximetry, heart rate, non-invasive blood pressure. Optional parameters 2-Channel Temperature: Range 0° - 50°C include end tidal CO2, respiratory rate, 2-channel temperature, and 2-channel invasive blood pressure (IBP). Accuracy �0.1°C plus temperature sensor tolerance Resolution 0.1°C Alarm Limits 20° to 50°C and Off Specifications YSI 400 Series Temperature Sensors, see pages 83-84 Displays & Controls: Sensor Compatibility Main Display 10.4 in diagonal LCD, 640 x 480 pixels Power Requirements: ECG: AC Input 100-240 VAC, 0.8 A, 50/60 Hz Heart Rate Range 20-350 bpm Battery Heart Rate Accuracy �2 bpm or �2% whichever is greater Operating Time 60-120 min QRS Detection Range: Dimensions (H x W x L) 30.5 x 18.0 x 34.0 cm (12.0 x 7 x 13.25 in) Normal 0.5 to 5 mV Weight 4.1 - 5 kg (9-11 lbs) High Sensitivity 0.1 to 5 mV Alarm Ranges Heart Rate 20-350 bpm and Off Order # Product Lead Selection I, II, or III ST1 72-6077 Advisor® 3 Lead ECG, SpO , Heart Rate and NIBP Display Gain Settings X0.5, X1, X2, X4 2 ST1 75-0259 Advisor® 3-Lead ECG, SpO , Heart Rate, NIBP, IBP, and SpO : 2 2 Temperature; includes Temperature Probe and Cable, IBP SpO2 Range 0-100% functional saturation Transducer and Cable.

SpO2 Accuracy �2% @ 70-100%, <70% unspecified ST1 75-0260 Advisor® 3 Lead ECG, SpO2, Heart Rate, NIBP, End Tidal CO2 Pulse Rate Range 20-350 bpm and Respiration Rate Pulse Rate Accuracy �2 bpm or �2% whichever is greater ST1 75-0261 Advisor® 3 Lead ECG, SpO2, Heart Rate, NIBP, 2-Channel IBP, SpO2 Alarm Ranges 50-100% and Off End Tidal CO2, 2-Channel Temperature and Respiration Rate; NIBP: includes Temperature Probe and Cable, Reusable Esophageal/ Method of Measurement Oscillometric with step-down deflation Rectal Temperature Probe, IBP Transducer and Cable, and Capnograph start-up kit Systolic Pressure 40 to 265 mmHg Accessories and Replacement Products Mean Arterial 27-222 mmHg ST1 72-3233 CO Calibration Kit Disastolic Pressure 20-200 mmHg 2

ST1 72-3246 Moisture Trap VITAL SIGNS Pulse Rate Range 25 to 350 bpm Pulse Rate Accuracy 25-250 bpm �2% or 3 bpm whichever is greater ST1 72-3254 Reflectance Sensor 251-300 bpm �5%, <25 or >300 unspecified ST1 72-3256 Universal “Y” Sensor Inflation Pressure Settings 200 mmHg Cat, 150 mmHg Dog, 120 mmHg Horse ST1 72-3258 “C” Sensor for cats, dogs and horses. Adjustment Range 60-280 mmHg Cat, 120-280 mmHg Dog/Horse ST1 72-6003 Mini Clip Sensor for small dogs, small cats and small NIBP Clinical Accuracy Based on human algorithm and meets accuracy non-human primates requirements for ANSI/AAMI SP10: 1992 and 2002 ST1 72-3157 5 ft Oximetry Extension Cable Auto Interval Times 1-10, 15, 20, or 30 minutes; 1, 2, 4 or 8 hrs ST1 75-0264 3 Lead ECG Wires with Alligator Clips, 40 in Alarm Range 1 mmHg Steps and Off ST1 75-0265 3 Lead ECG Wires with Alligator Clips, 60 in Patient Safety Max cuff inflation time is 75 sec; max blood ST1 75-0249 3 Lead ECG Cable (Can be used with 75-0264, 75-0265) pressure reading time is 120 sec ST1 72-6011 Temperature Cable Capnography: ST1 59-9808 Small Flexible Vinyl Rectal/Esophageal Probe, pkg. of 1 Measurement Non-Dispersive IR Absorption ST1 75-0249 Invasive Blood Pressure Transducer Cable Measurement Range 0-10% CO2 STPD ST1 75-0248 Invasive Blood Pressure Transducer Display Range 0 to 100 mmHg; 0 - 14kPa; 0-10% CO2 Accuracy �2 mmHg or 4% of reading whichever is greater ST1 72-3253 CO2 Monitor Exhaust Kit for Scavenging Halogenated Gasses Advisor is a registered trademark of Smiths Medical.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 205 CAPNOGRAPHY

CAPNOGRAPHY Capnography is the first indicator of the quality of anesthesia and the health of the subject. The lungs are very susceptible to anesthesia and a good common indicator for metabolic function. Capnography can easily indicate if the anesthetic conditions are non- optimal through the shape of the capnograph. For instance rebreathing is indicated by a

continuously rising CO2 level or in disease models the alveolar plateau indicating healthy lungs disappears.

The level of carbon dioxide at the end of expiration (end tidal carbon dioxide, ETCO2) is normally within a few mmHg of the arterial carbon dioxide level. ETCO2 is very useful for assessing adequacy of ventilation both during spontaneous respiration and when using a ventilator.

HSE-HA Capnograph Type 340 Specifications

for Small Rodents CO2 Range 0 to 10%

Tracheal Pressure Range -10 to +80 cmH2O • Capnography for mice and rats Airflow Range • Built-in highly sensitive temperature and pressure Mouse ±3.00 ml/sec

compensated infrared spectroscopy CO2 sensor Rat ±30.00 ml/sec • Very low system compliance Tidal Volume Range

VITAL SIGNS VITAL Mouse 1.0 ml • Basic evaluated parameters are CO2 and respiration rate Rat 5.0 ml • Optional flow heads to extend function to create a complete respiratory survey and monitoring system. Respiratory Rate Range 0 to 300 bpm Output Signal Range ±4 V – Peak Inspiratory Flow Sample Rate – Peak Expiratory Flow ~10 ml/min – Peak Inspiratory Pressure Mouse – Positive End-Expiratory Pressure Rat ~15 ml/min – Tidal Volume – Respiratory Rate Order # Product

• Analog output of CO2 waveform and end tidal CO2 for ST1 73-3809 Capnograph Type 240, 100-240 VAC, 50/60 Hz data collection on all versions. ST1 73-3816 Flow Pressure Sensor for Mouse to Capnograph Type 340 ST1 73-3817 Flow Pressure Sensor for Rat to Capnograph Type 340 • Analog output of CO2 waveform, end-tidal CO2, respiratory flow, tracheal pressure, respiratory rate and ST1 73-4166 Mouse Cannulating Kit tidal volume in extended version. ST1 73-4165 Rat Cannulating Kit

ST1 73-4164 CO2 Inlet Tube Set for Capnograph Type 340 Accessories ST1 73- 0500 Lab stand with triangular base plate

206 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com CAPNOGRAPHY

V8401 Capnocheck V3395 Temperature SpO2 and Respiration Monitor with SAC™ Technology • Hand-held Capnograph for small animal veterinary facilities (i.e. Cat) • Portable temperature, SpO2, pulse rate and respiration • Highly portable unit that measures capnography, monitor

respiration rate and ETCO2 • Ideally suited for veterinary clinical settings, large rodents • Side-stream technology for use on intubated and through horses non-intubated subjects • Advanced digital oximetry with SAC™ technology • One-touch function keys for easy operation • Plethysmograph waveform displayed • Adjustable and visible audible alarm limits Specifications • 99 patient memory Display LCD, with electroluminescent back light Indicators High, medium and low priority alarm Alarm mute Specifications

AC power Sp02:

Graphic Trends ETCO2 and respiration rate Range 50% to 100%

Waveforms CO2 waveforms Accuracy ±2% at 70% to 100%

Numerical Data and Messages ETCO2, respiration rate and Calibration Factory calibrated status messages Alarm Ranges 50% to 100% (1% increments), and OFF Sidestream Capnography: Pulse Rate: Measurement Non-dispersive IR absorption Range 2 to 350 bpm

Measurement Range 0 to 10% CO2, STPD Accuracy > of ±2% or ±2 BrPM over full range Units User-selectable: mmHg, Vol. %, kPa Temperature:

Display Range 0 to 100 mmHg, 0 to 13.3 kPa, 0 to 10% CO2 Range 0° to 60°C Accuracy ±2 mmHg or 4% (<50breaths/min) Accuracy ±1°C whichever is greater Alarms No alarms for temperature 51 to 80 breaths/min: +4/-10% of reading Respiration: 81 to 150 breaths/min: +4/-20% of reading Range 5 to 150 bpm Averaging 4 breath average Sensitivity 7 levels N2O Compensation Selectable 40% (default = off) Accuracy < ±2% or ±2% BrPM over full range System Response Time 2.46 sec to 90% with 8 ft patient time Dimensions, H x W x D 12.7 x 11.1 x 7.4 cm (5.0 x 4.38 x 2.9 in) Flow Rate 120 ±20 ml/min Weight 624 g (22 oz) Calibration Manual 2 point Battery Life NiMH rechargeable battery allow for 2 hrs of Respiration rate 0-150 bpm continuous use Averaging 4 bpm Included Components: Serial Output Infrared port for printer • AC charger • x1 5-foot Oximetry Extension Cable Battery Lithium Ion, 7.4 VDC • x1 Refractance Sensor • Operations Manual VITAL SIGNS User Replaceable • x1 Temperature Cable and Probe • Protective Boot Rechargeable • x1 Respiration Cable and Probe Continuous life of 6 hrs 2.5 hrs charging time Dimensions, H x W x D 12.7 x 11.1 x 7.4 cm (5 x 4.38 x 2.9 in) Order # Product

Weight 0.63 kg (22 oz) ST1 72-6008 Temperature, SpO2 and Respiration Monitor Replacement Parts Order # Product ST1 72-3254 Reflectance Sensor ST1 72-6016 Hand Held Capnometer, 120 VAC, 60 Hz ST1 72-6009 AC Charger, 110 VAC, 60 Hz ST1 72-6017 Hand Held Capnometer, 220 VAC, 50 Hz ST1 72-6012 Temperature Probe ST1 72-6011 Temperature Cable ST1 72-3253 CO2 Monitor Exhaust Kit ST1 72-3232 Patient Attachment Kit ST1 72-6013 Respiration Cable/Probe ST1 72-3256 Universal “Y” Sensor Accessories AC Charger, 220 VAC, 50 Hz SAC is a trademark of Smiths Medical. ST1 72-6010

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 207 CAPNOGRAPHY

Specifications Display: Displayed Trends Graphical display, factory selectable sample rate, user selectable trend

CO2: Measurement Non-dispersive IR absorption

Measurement 0 to 10% CO2 Range Units User-selectable: mmHg, Vol. %, kPa Display Range 0 to 100 mmHg or 0 to 10.0% or 0 to 13.3 kPa Accuracy ±2 mmHg;±0.3%; ±kPa or 4% of reading whichever

is greater (0 to 10% CO2)

N2O Compensation User-selectable 40% (default = off) V9004 Series Intelligent Capnography Averaging 4-breath average Respiration Rate: Range 0 to 120 ±bpm V9004 Series Capnograph monitor provides capnography, ETCO2, Averaging 4-breath average inspired CO2 and respiration rate. SpO2 (optional): • Incorporates sidestream technology for application with Range 0 to 100% intubated and non-intubated patients Accuracy ±2% at 70 to 100%; ±3% at 50-69%

• End-tidal CO2 numeric value Averaging 4, 8, 16 beat, user selectable

FiO2 (optional): • End-tidal CO2 wave form Range 0 to 100% • Inspired CO and respiration rate 2 Accuracy ±2% • High resolution vacuum fluorescent display Response Time < 10 sec to 90% • Simplified menu structure Pulse Rate (optional): Range 20 to 350 bpm • Flexibility to incorporate SpO2 and FiO2 Accuracy 2% over full range • Patented moisture removal system Averaging 8 or 16 seconds; user-selectable Drift < 2% of full scale per month Battery Requirements Nickel Cadmium battery, 6 VDC internal rechargeable, not replaceable, fully charged continuous-use life 2hrs approximately, maximum full charge time 4 hrs. Serial Output RS-232C: tabular trends, patient data

Analog Output Any three of: CO2 waveform, Plethysmogram, End Tidal CO2, Respiration Rate, Inspired CO2, % SpO2, Pulse Rate, Fractional Inspired Oxygen, 0V or 1V Cal signal, Range 0 to 1 VDC full scale Safety Approvals Designed to meet IEC 601-1, CSA 125, UL 544 and IEC 601-1-2 (EMC CE), ISO 9001 Certified Dimensions, H x W x D 88.9 x 254 x 139.8 mm (3.5 x 10.0 x 5.5 in) Weight 2.27 kg (5 lbs) VITAL SIGNS VITAL Order # Product ST1 72-3240 Table Top Capnograph, 110 VAC, 60 Hz ST1 72-5807 Low Flow Capnograph, 110 VAC, 60 Hz ST1 72-3276 Table Top Capnograph, 220 VAC, 50 Hz ST1 72-3241 TT Capnograph and Oximeter, 110 VAC, 60 Hz ST1 72-3277 TT Capnograph and Oximeter, 220 VAC, 50 Hz

ST1 72-3242 TT Capnograph, Oximeter and FiO2, 110 VAC, 60 Hz

ST1 72-3278 TT Capnograph, Oximeter and FiO2, 220 VAC, 50 Hz

ST1 72-3138 Adapter T, FiO2

ST1 72-3139 FiO2 Sensor

ST1 72- 3140 FiO2 Sensor Cable ST1 72- 3279 V3408 Graphics Printer and Cable ST1 72- 3214 AC Adapter Charger, 110 VAC, 60 Hz ST1 72- 3215 AC Adapter/Charger, 208 to 252 VAC, 50 Hz ST1 72- 3205 Printer Paper, pkg. of 4 ST1 72- 3179 PC/Printer Interface Cable ST1 72- 3175 IV Pole Bracket ST1 72- 3254 Reflectance Sensor ST1 72- 3256 Mini Clip Universal Y Sensor ST1 72- 6003 Mini Clip

208 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com BLOOD PRESSURE

BLOOD PRESSURE Blood pressure is the most common diagnostic tool for determining the health and well-being of a subject during surgery and a critical measurement for cardiovascular research, providing heart rate, systolic and diastolic pressures and mean aterial pressure (MAP). Monitoring blood pressure allows the assessment of the quality of circulation, indications of how well the blood is perfusing organs, and is one of the variables that enables determination of the depth of anesthesia. Blood pressure can be measured invasively (fluid-filled catheter inserted into a vessel, or a miniature pressure catheter in the vessel) or non-invasively (using an occluding pressure cuff). All commercial non-invasive blood pressure systems (NIBP) for rodents tend to monitor blood pressure at the tail of the animal.

Specifications Output Voltage Factory set at 1.0 V/100 mmHg via BNC connector; calibrated up to 300 mmHg Linearity ±1.5% of full scale Compliance 14 µl displacement/100 mmHg, including Research Blood 1 305 mm (12 in) of standard 3 mm ( ⁄8 in) ID vinyl Pressure Transducer tubing Dome Volume 300 µl Pressure Range -50 to +300 mmHg Overload Pressure 3000 mmHg Zero Offset Control -50 to +100 mmHg Natural Frequency > 500 Hz, dry Electrical Isolation > 1 kV Carrier Frequency 2 MHz Output Impedance 2 kΩ Input Liquid Connectors Dual transparent female Luer lock Drift Negligible after 5 minute warm-up Sterilization of Transducer Chemical: Alcide, Cidex, etc. Dimensions:

1 1 1 Transducer, H x W x D 43 x 30 x 55 mm (1 ⁄ 2 x 1 ⁄8 x 2 ⁄4 in) Manual Pressure 3 Calibrator Handle, OD x L 9.7 x 76.2 mm ( ⁄8 x 3 in) 3 3 Amplifier, H x W x D 51 x 95 x 86 mm (2 x 3 ⁄4 x 3 ⁄8 in) Display LCD 7.6 mm (0.3 in) high numbers Weight 908 g (2 lbs)

Order # Product ST1 72-4496 Research Blood Pressure Transducer, 115 VAC, 60 Hz ST1 72-4497 Research Blood Pressure Transducer, 230 VAC, 50 Hz

Replacement Dome, pkg. of 1 VITAL SIGNS Research Grade Blood Pressure Transducer ST1 72-4498 Accessories (RGBP) ST1 73-4479 Manual Pressure Calibrator Kit, Range 0 to 300 mmHg Ideal for monitoring blood pressure during surgery. Sensitive ST1 73-0096 Three-Way Stopcock Type 956R Stainless Steel enough for research applications. ST1 73-0097 One-Way Stopcock Type 9500 Stainless Steel ST1 75-0030 One-Way Stopcock Sterile, FLL to MLL, pkg. of 100 • Versatile and accurate pressure transducer and amplifier ST1 75-0039 Three-Way Stopcock Sterile, pkg. of 100 • Simple to use and robust ST1 73-4140 Lab Stand with Triangular Base Plate with 16 cm (6.3 in ) Rod • BNC output for connection to data acquisition system • Easy to read 3 digit display in mmHg • Domes are supplied sterile and are semi-disposable. Blood only contacts the diaphragm and it can be resterilized (EtO, Cidex).

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 209 BLOOD PRESSURE

Pressure transducer APT300 with 3m cable Specifications and connector for PLUGSYS TAM Amplifier Operating Pressure -300 to +300 mmHg Overpressure 4000 mmHg Sensitivity 5 µV/V/mmHg (±1%) Temperature Coefficient 0.1%/°C Zerodrift < 0.2 mmHg/°C Zero Offset < 25 mmHg Excitation Voltage 2 to 15 VDC (or AC up to 5kHz) Isolation Against Fluid > 5,000 V Operating Temperature 15° to 40°C Storage Temperature -25° to 70°C Volume Displacement < 0.04 mm3/100 mmHg Output Impedance 365 Ω ±1% Frequency Response > 1 kHz Cable Length 3 m (9.8 ft)

Order # Product ST1 73-3862 APT300 Pressure Transducer for PLUGSYS TAM Amplifier ST1 73-3863 APT300 Pressure Transducer for Harvard UK Transducer Interface ST1 73-3864 APT300 Pressure Transducer for Grass Amplifiers ST1 73-3865 APT300 Pressure Transducer for Gould 6600 Series Replacement APT300 ST1 73-3866 APT300 Pressure Transducer for ADInstruments Bridge Amp transducer head ST1 73-3878 APT300 Pressure Transducer for DSI/Ponemah 7700 Amplifier Accessories ST1 73-3860 Replacement Cable with Contact Plate for PLUGSYS TAM Amplifier ST1 73-3861 Replacement APT300 Transducer Head ST1 73-3868 Holder for APT300 Transducer, 8 mm Rod, Length 160 mm (6.3 in) Holder for APT300 transducer, ST1 73-3869 Holder for APT300 Transducer, 8 mm Rod, 8 mm rod, length 160 mm Length 75 mm (2.95 in) ST1 73-0566 Perspex Block Clamp to Mount Transducer on a Rod ST1 73-0500 Stand with Block Clamp ST1 73-4479 Manual Pressure Calibrator Kit, Range 0 to 300 mmHg

Replacement cable with contact plate Holder for APT300 transducer, 8 mm rod, length 75 mm

VITAL SIGNS VITAL APT300 Blood Pressure Transducer

Ideal for sensitive arterial pressure monitoring in vivo as well as for perfusion pressures in isolated organs. • Inexpensive • Reliable • Accurate • Low volume displacement • Suitable for all arterial pressure applications, including mouse arterial pressure • Easy to fill • Stopcocks included • Simple holder for rod mounting1

1When ordering an APT300 please add Holder.

210 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com BLOOD PRESSURE

Reusable TRA021 Pressure Transducer Sterile Single Use Wide Range Pressure Sensors

Panlab’s TRA021 is a rugged, economical, reusable blood pressure These are small scale in-line sterile pressure sensors suitable for a transducer suitable for routine laboratory arterial and venous blood variety of applications, i.e. in vivo, ex vivo, in situ and regenerative pressure. organ and cellular applications. • Dome-type design makes for good general use blood • Male/Female luer lock with port cover for female luer lock pressure transducer end for dead-end applications. • Ideal for arterial or venous pressures • In-line pressure transducers for low flow rates when used 1 1 with ⁄8 in or ⁄16 in barbed connectors

1 3 Specifications • May be paired with adapter Tee-connectors, ⁄4 in or ⁄8 in, Range -50 to +300 mmHg for non-in-line applications Sensitivity 4 µV/V/mmHg Specifications Bridge Resistance 350 W Accuracy Better than ±2% of reading in the range of 5 to 10 VDC Excitation Voltage 0 to 6psi (0 to 0.41 bar or 0 to 310 mmHg) 3 Volume Displacement 0.05 mm /100 mmHg Better than ±3% of reading in the range of Total Volume 0.25 ml 6 to 30psi (0.41 to 2.07 bar) Weight 85 g (2.99 oz) In range of 30 to 60psi (2.07 to 4.14 bar) Dimensions 18 x 24 x 74 mm (0.7 x 0.95 x 2.9 in) typically better than ±5% of reading Pressure Range -7 to +75 psi (-0.48 to +5.2 bar) Biocompatibility All materials in contact with product fluid path Order # Model Product meet USP Class VI requirements ST1 76-0578 TRA021A Reusable Research Pressure Transducer for Manufacturing FDA Registered ISO 13485 certified facility; ISO510A Environment Class 100,000 clean room ST1 76-0580 TRA021HS Reusable Research Pressure Transducer for Hugo Gamm Irradiation Up to 50 kiloGrays Sachs PLUGSYS TAM Amplifiers Operating Temperature 15 to 40°C (other ranges with process qualification) ST1 76-0582 TRA021AD Reusable Research Pressure Transducer for Storage Temperature -25° to 65°C ADInstruments Bridge Amplifiers Input/Output Impedence 270 to 4,000 Ω Accessories Excitation Voltage 2.5 to 10 VDC ST1 73-4479 Manual Pressure Calibrator Kit, Range 0 to 300 mmHg Sensor Output 0.2584 mV/psi/Volt ST1 73-0096 Three-Way Stopcock Type 956R Stainless Steel Connector Custom molded water-tight 4 pin connector; ST1 73-0097 One-Way Stopcock Type 9500 Stainless Steel signal ± and excitation ± ST1 75-0030 One-Way Stopcock Sterile, FLL to MLL, pkg. of 100 ST1 75-0039 Three-Way Stopcock Sterile, pkg. of 100 Order # Product ST1 88-0360 Sterile Pressure Sensor, pkg. of 10

1 1 ST1 88-0361 ⁄4 x ⁄4 in Barbed Straight Connector with Female Luer Port, polycarbonate, pkg. of 10

3 3 ST1 88-0362 ⁄8 x ⁄8 in Barbed Straight Connector with Female Luer Port,

polycarbonate, pkg. of 10 VITAL SIGNS

1 1 ST1 88-0363 ⁄2 x ⁄2 in Barbed Straight Connector with Female Luer Port, Polycarbonate, pkg. of 10 ST1 88-0364 Luer Polysulphone 3-way Stopcock, pkg. of 10 ST1 88-0365 Reusable Shielded Cable, 12 ft, Unterminated, Colored Leads, Connector for amplifier, supplied by customer. ST1 88-0366 Interface Cable to Work with Sterile Pressure Sensors (ST1 88- 0360) Connecting to ORCA Bioreactor Controller. This connects up to 4 Pressure Transducers to the ORCA Bioreactor Controller ST1 88-0367 Interface Cable to Work with Sterile Pressure Sensors (ST1 88-0360) Connecting to Hugo Sachs PLUGSYS TAM Amplifier Modules ST1 88-0368 Interface Cable to Work with Sterile Pressure Sensors (ST1 88-0360) Connecting to ADInstruments Bridge Amp ST1 88-0369 Interface Cable to work with Sterile Pressure Sensors (ST1 88-0360) Connecting to Harvard Apparatus Transducer Amplifier Interface ST1 73-4479 Manual Pressure Calibrator Kit, Range 0 to 300 mmHg

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Specifications Pressure Range -30 to +300 mmHg Over Pressure Tolerance -700 to +7,800 mmHg Frequency Response > 1,200 Hz, 15 bandwidth shall be > 200 Hz Transducer Excitation 1 to 10V RMS Transducer Excitation 1,100 to 3,450 Ω Input Impedance Transducer Signal 270 to 330 Ω Output Impedance Nominal Sensitivity (gain) 5 µV/V/mmHg Unbalance (Zero Balance) ±40 mmHg Accuracy 2% of the reading or ±1 mmHg, whichever is greater over the operating range Operating Temperature 15° to 40°C

Order # Product ST1 72-4293 DTXPlus Sterile Disposable Single-Use Transducer, pkg. of 10, with HAI Interface Cable ST1 72-4297 DTXPlus Sterile Disposable Single-Use Transducer, pkg. of 10, with Hugo-Sachs PLUGSYS Interface Cable ST1 72-4294 DTXPlus Sterile Disposable Single-Use Transducer, pkg. of 10, with Grass Amplifiers Interface Cable ST1 72-4295 DTXPlus Sterile Disposable Single-Use Transducer, pkg. of 10, with PROPAQ Interface Cable ST1 72-4296 DTXPlus Sterile Disposable Single-Use Transducer, pkg. of 10, with GOULD 600 Interface Cable DTXPlus Sterile Disposable Pressure Transducer Accessories ST1 73-4479 Manual Pressure Calibrator Kit, Range 0 to 300 mmHg Blood pressure monitoring is an essential component for care of subjects. These new DTXPlus blood pressure transducers minimize ST1 73-0096 Three-Way Stopcock Type 956R Stainless Steel distortion in the pressure waveform and maximize accuracy. ST1 73-0097 One-Way Stopcock Type 9500 Stainless Steel ST1 75-0030 One-Way Stopcock Sterile, FLL to MLL, Box of 100 • Individually packaged, sterile, disposable blood ST1 75-0039 Three-Way Stopcock Sterile, pkg. of 100 pressure transducers ST1 72-4292 Replacement DTXPlus Disposable Single-Use BP Transducer, • Shelf life of 5 years pkg. of 10 (Interface Cable not included) • Stopcocks must be purchased separately ST1 60-0298 Interface Cable for HAI Transducer Interface • Class III according to European Medical Devices ST1 72-2882 Interface Cable for HA-HSE TAM Amplifier Modules Directive 93/42/EEC ST1 60-0300 Interface Cable for Grass Amplifier ST1 60-0297 Interface Cable for Propaq Monitors ST1 60-0296 Interface Cable for Gould 6600 Series Amplifiers ST1 72-2883 Interface Cable, Universal Connector to Tinned Leads (no connector) for use with other equipment, mating connector supplied by customer VITAL SIGNS VITAL

212 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com BLOOD PRESSURE

Specifications

Pressure Range ±75 mmHg (±100 cmH2O) Volume Displacement 0.06 mm3/10 mmHg Linearity ±0.15 mmHg Long Term Drift ±0.04 mmHg Overload -760 (=vacuum) to 4,000 mmHg Measurement Media All gasses and liquids which are compatible with Macrolon® Temperature Range 0 to 50°C Zero Drift ±0.04 mmHg/10°C (0 to 50°C) Range Drift ±0.04 mV/10°C (±0.04 mmHg/10°C) (0 to 50°C) Electrical Data: Supply Voltage 5 V (4.5 to 5.5 V) DC Only Current Loading 15 mA max. Sensitivity 1 mV/mmHg, Nominal Output Resistance 300 Ω, nominal Frequency Range 0 to 100 Hz P75 Venous Pressure Transducer Connection Cable Approximately 1.5 m (4.9 ft) Long Suitable Amplifiers Any Bridge Amp providing 5 VDC excitation voltage Hugo Sachs' rugged low pressure transducer is highly sensitive for Mechanical Data: research and surgical applications involving liquids or gasses. Pressure Connections Luer Taper, Male • For low pressure applications with liquids and gasses Weight 0.35 kg (0.8 lbs) ±75 mmHg Dimensions, H x W x D 40 x 40 x 35 mm (1.57 x 1.57 x 1.38 in) • Excellent sensitivity and baseline stability Mounting Rod 8 x 70 mm (0.31 x 2.76 in) • Applications include: - Venous blood pressure Order # Product - Esophageal pressure with fluid filled catheter ST1 73-0020 Blood Pressure Transducer P75 for PLUGSYS TAM Amplifier - Perfusion pressure in isolated lung and liver ST1 73-0021 Blood Pressure Transducer P75 for Harvard Apparatus - Perfusion pressure on perfused hollow organs, Transducer Interface such as the esophagus ST1 73-0022 Blood Pressure Transducer P75 for Grass Amplifiers • Robust construction with a removable Macrolon® dome, ST1 73-0023 Blood Pressure Transducer P75 for Gould 6600 Series easy to fill, bubble free ST1 73-0024 Blood Pressure Transducer P75 for Gould 4600 Series • Transducer is a metal housing with ceramic pressure ST1 73-3738 Blood Pressure Transducer P75 for ADInstruments sensor giving the P75 excellent resistance to a variety of ST1 73-0025 Replacement Dome for Venous Blood Pressure media Accessories ST1 73-4479 Manual Pressure Calibrator Kit, Range 0 to 300 mmHg ST1 73-0096 Three-Way Stopcock Type 956R Stainless Steel ST1 73-0097 One-Way Stopcock Type 9500 Stainless Steel ST1 75-0030 One-Way Stopcock Sterile, FLL to MLL, pkg. of 100 ST1 75-0039 Three-Way Stopcock Sterile, pkg. of 100 VITAL SIGNS

Macrolon® is a registered trademark of Bayer.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 213 BLOOD PRESSURE

2F Pressure Catheter SPR-407 Millar Pressure Transducers Millar pressure catheters continue to represent the gold-standard for high-fidelity pressure measurements for both systemic and intraventricular applications. 1F Pressure Catheter SPR-1000 Millar ultraminiature pressure sensors were developed for measuring pressures in small laboratory animals. In these models, the catheter body is smaller than the tip sensor to allow flexibility and to minimally obstruct the vessels or valves through which it passes. Millar Mikro-Tip® Catheter Pressure Transducers were developed 1F Pressure Catheter SPR-671 to overcome the well-known problems and errors associated with fluid-filled catheter pressure measurement systems. The pressure sensor, which has an extremely high natural frequency, is located at the distal end of the catheter. High-fidelity pressure and sound measurements without phase and amplitude errors can be made simultaneously directly at the source.

Harvard Apparatus Spotlight On: Millar Pressure Volume Systems

Featured System: Millar Pressure Volume Systems - MPVS Ultra Multi-Segment For All Animal Models

Summary: The MPVS Ultra simultaneously and continuously measures high- fidelity left ventricular pressure and relative volume from the intact beating hearts of animals ranging in size from transgenic mice to domestic livestock. Using the MPVS Ultra, cardiovascular pressure and volume signals can be plotted against each other in real time, generating the characteristic pressure-volume (P-V) loops that are an excellent illustration of the cardiac cycle in normal or diseased conditions of the living heart. MPVS Ultra is the only complete solution for measuring real-time cardiovascular pressure and volume in small and large animal models with an industry-leading seven volume segments. Millar catheters and hardware integrate seamlessly with Harvard Apparatus VITAL SIGNS VITAL Physiology systems to create a complete Cardiovascular Physiology solution.

Scan this QR code to view the MPVS System:

Mikro-Tip® is a registered trademark of Millar Instruments.

214 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com BLOOD PRESSURE

Order # Model Product Connector Type Animal Model ST1 72-9779 SPR-671 Ultra-Miniature Pressure Transducer for Mouse, Model SPR 671, Catheter Length 65 cm Low Profile Mouse (2.6 in), Sensor Type 1.4 F ST1 72-9779NR SPR-671 Ultra-Miniature Pressure Transducer for Mouse, Model SPR 671, Catheter Length 65 cm Low Profile Mouse (2.6 in), Sensor Type 1.4 F - NO REPAIR ST1 72-9781 SPR-1000 Ultra-Miniature Pressure Transducer for Mouse, Model SPR 1000, Sensor Type1.0 F Low Profile Mouse ST1 72-9775 SPR-407 Ultra-Miniature Pressure Transducer for Rat, Model SPR 407, Main Size 1.5 F, Viking Rat Catheter Length 140 cm (5.1 in), Straight Tip, Sensor Type ST1 72-9775NR SPR-407 Ultra-Miniature Pressure Transducer for Rat, Model SPR 407, Main Size 1.5 F, Viking Rat Catheter Length 140 cm (5.1 in), Straight Tip, Sensor Type 2F, NO REPAIR ST1 72-9776 SPR-513 Ultra-Miniature Pressure Transducer for Rat, Model SPR 513, Main Size 1.5 F, Viking Rat Catheter Length 140 cm (5.1 in), Angled 5mm from tip, Sensor Type 2F ST1 72-9783 SPR-320 Millar Mikro-Tip® Pressure Transducer for Rat, Model SPR 320, Main Size 2 F, Viking Rats Catheter Length 140 cm (5.1 in), Straight Tip ST1 72-9783NR SPR-320 Millar Mikro-Tip® Pressure Transducer for Rat, Model SPR 320, Main Size 2 F, Viking Rats Catheter Length 140 cm (5.1 in), Straight Tip - NO REPAIR ST1 72-9798 SPR-721 Millar Mikro-Tip® Pressure Transducer for Large Rat/Guinea Pig, Model SPR-721 2.5 F Viking Rats Dual Pressure Catheter, 135 cm (5.3 in), Straight Tip, 5cm Sensor Spacing ST1 72-9987 SPR-350 Millar Mikro-Tip® Pressure Transducer for Large Rat/Guinea Pig, Model SPR-940 2.5 F Viking Rats Dual Pressure Catheter, 135 cm(5.3 in), Straight, 2.5cm Sensor Spacing ST1 72-9777 SPR-524 Ultra-Miniature Pressure Transducer for Rabbit/Cat, Model SPR 524, Main Size 2.3 F, Low Profile Rabbits/Cats Catheter Length 100 cm (3.9 in), Sensor Type 3.5F - NO REPAIR ST1 72-9778 SPR-595 Ultra-Miniature Pressure Transducer for Rabbit/Cat, Model SPR 595, Main Size 2.2 F, Viking Rabbits/Cats Catheter Length 60 cm (2.4 in), Angled Tip, Sensor Type 3F Harvard Apparatus Spotlight On: Millar Pressure Volume Systems ST1 72-9780 SPR-882 Ultra-Miniature Pressure Transducer for Rabbit/Cat, Model SPR 882, Main Size 2.2 F, Viking Rabbits/Cats Catheter Length 140 cm (5.1 in), Straight Tip, Sensor Type 3F ST1 72-9784 SPR-330A Millar Mikro-Tip® Pressure Transducer for Rabbit, Model SPR 330A, Main Size 3 F, Viking Rabbits/Cats Catheter Length 130 cm (5.1 in), Straight Tip ST1 72-9785 SPR-340 Millar Mikro-Tip® Pressure Transducer for Rabbit, Model SPR 340, Main Size 4 F, Viking Rabbits/Cats Catheter Length 120 cm (4.7 in), Curved Tip ST1 72-9786 SPR-340S Millar Mikro-Tip® Pressure Transducer for Rabbit, Model SPC 340S, Main Size 4 F, Viking Rabbits/Cats Catheter Length 120 cm (4.7 in), Straight Tip ST1 72-9782 MPR-500 Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model MPR 500, Viking Dogs/Pigs/Sheep Main Size 5 F, Catheter Length 70 cm (2.8 in), Straight Tip, Non-Repairable ST1 72-9787 SPR-350 Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 350, Viking Dogs/Pigs/Sheep Main Size 5 F, Catheter Length 120 cm (4.7 in), Curved Tip ST1 72-9788 SPR-350S Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 350S, Viking Dogs/Pigs/Sheep Main Size 5 F, Catheter Length 120 cm (4.7 in), Straight Tip ST1 72-9789 SPR-360 Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 360, Viking Dogs/Pigs/Sheep Main Size 6 F, Catheter Length 120 cm (4.7 in), Curved Tip ST1 72-9790 SPR-360S Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 360S, Viking Dogs/Pigs/Sheep Main Size 6 F, Catheter Length 120 cm (4.7 in), Straight Tip ST1 72-9791 SPR-370 Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 370, Viking Dogs/Pigs/Sheep Main Size 7 F, Catheter Length 120 cm (4.7 in), Curved Tip ST1 72-9792 SPR-370S Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 370S, Viking Dogs/Pigs/Sheep Main Size 7 F, Catheter Length 120 cm (4.7 in), Straight Tip ST1 72-9793 SPR-450 Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 450, Viking Dogs/Pigs/Sheep Main Size 5 F, Catheter Length 120 cm (4.7 in), Curved Tip, w/ Injection ST1 72-9794 SPR-450S Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 450S, Viking Dogs/Pigs/Sheep Main Size 5 F, Catheter Length 120 cm (4.7 in), Straight Tip, w/ Injection Lumen ST1 72-9795 SPR-470 Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 470, Viking Dogs/Pigs/Sheep VITAL SIGNS Main Size 7 F, Catheter Length 120 cm (4.7 in), Curved Tip, w/ Injection Lumen ST1 72-9796 SPR-471A Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 471A, Viking Dogs/Pigs/Sheep Main Size 7 F, Catheter Length 115 cm, Straight Tip, w/ Injection Lumen ST1 72-9797 SPR-474A Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 474A, Viking Dogs/Pigs/Sheep Main Size 7 F, Catheter Length 120 cm (4.7 in), Pigtail, Straight Tip, w/ Injection Lumen ST1 72-9799 SPR-780C Millar Mikro-Tip® Pressure Transducer for Dog/Pig/Sheep, Model SPR 780C 8 F Dual Viking Dogs/Pigs/Sheep Pressure Sensor, Pigtail, 120 cm (4.7 in), Straight, 5cm spacing ST1 72-9800 SPR-784A Millar Mikro-Tip Pressure Transducer for Dog/Pig/Sheep, Model SPR 784A 8.5 F Dual Viking Dogs/Pigs/Sheep Pressure Sensor, Pigtail, 120 cm (4.7 in), Straight, 5cm spacing

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 215 BLOOD PRESSURE

Model TC-510 Control Unit Order # Product Signal Conditioner, Cables and Adapters • Measures the pressure at the source ST1 72-9810 Control Unit Model TC-510 without Cable • Standardized sensitivity 5V/V/mmHg ST1 72-9731 SD-797 Connects TC-510 to ADInstruments Bridge Amp • Precalibrated and interchangeable ST1 72-9732 SD-810 Reversing Cable, Apical approach PV Catheters to CD Leycom • Pressure range -50 to +300 mmHg ST1 72-9734 AEC-10D Pressure Catheter with Low Profile Connector to • Frequency response flat up to 10 kHz ADInstruments Bridge Amp • Ultra-Miniature type for LVP measurement in mice ST1 72-9811 Cable TEC-5C to Connect Pressure Catheters with Viking Connectors to TC-510, 1.5 m (5 ft) • Reusable ST1 72-9812 Cable TEC-10C to Connect Pressure Catheters with Viking The Transducer Control Unit is essential as a passive interface Connectors to TC-510, 3.1 m (10 ft) between the pressure sensor of any standardized sensitivity Millar ST1 72-9813 Cable TEC-10D to Connect Pressure Catheters with Low Mikro-Tip® or Ultraminiature Catheter Pressure Transducer and Profile connectors to TC-510, 3.1 m (10 ft) strain gauge pressure amplifiers, which supply bridge excitation ST1 72-9814 PCU-2000 Control Unit, CE marked, patient isolated, line voltage and have balance and calibration controls for full-bridge powered dual & single pressure amplifier/interface unit strain gauge pressure transducers. The Model TC-510 includes ST1 72-9815 PEC-10C 3.1m (10 ft) Cable, Viking Connector to PCU-2000 controls for balancing and calibration. A connector cable with the Unit appropriate connector to attach the TC-510 Control Unit to the ST1 72-9816 PEC-10D 3.1 m (10 ft) Cable, Low Profile Connector to recorder preamplifler is required. PCU-2000 Unit ST1 72-9817 BNC-BNC Cable Note: The model TC-510 is NOT required for use with the PLUGSYS TAM ST1 72-9818 BNC-Phono Adapter amplifier modules or with the ADInstruments Bridge Amplifiers as there are direct-connect cables available for these amplifier options. ST1 72-9819 SD-778 3.1 m (10 ft) P-V Catheter Electrodes to CD Leycom Sigma 5 Unit Order # Product ST1 72-9841 Adapter Cable to Connect TC-510 to PLUGSYS Amplifiers Practice Catheters ST1 72-9842 HEC-10C Pressure Catheter with Viking Connector to PLUGSYS TAM Amplifier ST1 72-9979 SPR-1000 Mouse Pressure Practice Catheter 1 F, pkg. of 3 ST1 72-9843 HEC-10D Pressure Catheter with Low Profile Connector to ST1 72-9980 SPR-671 Mouse Pressure Practice Catheter 1.4 F, pkg. of 3 PLUGSYS TAM Amplifier ST1 72-9981 SPR-407 Rat Pressure Catheter 2 F, pkg. of 3 ST1 72-9844 AEC-10C Pressure Catheter with Viking Connector to ST1 72-9982 SPR-320 Rat Pressure Practice Catheter 2 F, pkg. of 3 ADInstruments Bridge Amp ST1 72-9983 SPR-524 Small Mammal Pressure Practice Catheter 3.5 F, ST1 72-9988 SD-974 Low Voltage Single Channel Control Unit, pkg. of 3 Battery Powered

Harvard Apparatus Spotlight On: Left Ventricular Pressure & PV Measurement

Featured Article: Transgenic Rat Hearts Overexpressing SERCA2a Show Improved Contractility Under Baseline Conditions and Pressure Overload VITAL SIGNS VITAL Equipment Featured: IH-SR Working Heart, Millar pressure catheter Introduction: While many researchers use pressure or pressure-volume catheters for determination of cardiovascular parameters in vivo, these transducers are also popular for use in the ex vivo isolated perfused working heart preparation. The Hugo Sachs IHSR system configured for working heart has a dedicated catheter pathway that allows the introduction of a pressure or pressure volume catheter through the aortic valve, negating the need to puncture the apex of the heart. Müller, O.J., Lange, M., Rattunde, H., Lorenzen, H-P., Müller, M., Frey, N., Bittner, Summary: C., Simonides, W., Katus, H.A., Franz, W-M. (2003) Cardiovascular Research, In order to determine if the transfer of sarcoplasmic reticulum Vol 59(2003): 380-389. Ca2+-ATPase (SERCA2a) cDNA can rescue the reduced SERCA activity that occurs in failing myocardium, Müller, et al (2003) established independent transgenic rat lines and studied the effects Scan this QR code of overexpression on cardiac function under normal and pressure to view the article: overload conditions using the working heart perfusion method.

Mikro-Tip® is a registered trademark or Millar Instruments.

216 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com BLOOD PRESSURE

ST1 73-0045 Model 603 PLUGSYS Main Frame Case

MiniCase ST1 73-1523 and PLUGSYS Module TAM-A

ST1 73-1521 Model 601 with 5 PLUGSYS Modules

Hugo-Sachs Electronik Transducer Specifications Amplifier Modules1 Transducer Input 6-pin socket with screw lock (binder, Amphenol Tuchel) differential input circuit, input impedance 10 Universal DC bridge amplifier used to amplify physiological signals 10 Ω like blood pressures, contraction force or contraction displacement Gain Selectable ranges by internal jumper: 0.2 to 10, 0.4 to 20, 1 to 50, 2 to 100, 4 to 200, 10 to 500, 20 to using transducers based on a resistive Wheatstone bridge. 1,000. Fine adjustment through 10-turn trimmer. Transducers with a built-in preamplifier which have a high level DC Signal Output a) On front panel through BNC socket = 10 V output voltage can also be connected. pulsatile filtered or mean signal output internally selectable The TAM-A is equipped with an analog LED bar graph signal indicator and is best suited for applications which require the b) Through bus connector to PLUGSYS monitoring of dynamic signals, e.g. blood pressures, respiratory measuring system through links= 10 V pulsatile filtered and mean signal voltage air flow, respiratory pressures, force etc. The TAM-D Amplifier is equipped with a digital LED display and is best used when Output Low-Pass Filter a) Selectable by switch on front panel for pulsatile output signal: 1, 100, 300 Hz measuring constant or minimally changing, non-phasic pressures. b) Selectable by internal jumper for mean output signal: 0.1, 0.3 Hz Recommended Transducers Electrical Calibration Selectable by switch on front panel: • Arterial blood pressure APT300 a) 0 V output signal with switch in position '0' b) Positive or negative calibration output voltage • Intracardial LVP Millar Tip catheters adjustable with 10-turn trimmer if switch is in • Venous blood pressure P75 position 'CAL' VITAL SIGNS • Respiratory air flow DLP2.52 PLUGSYS Width 2 slot units • Tracheal pressure MPX2 • Respiratory pressures P75 Order # Product ST1 73-0065 Transducer Amplifier Module TAM-A 1Modular units please add housing. ST1 72-7081 Transducer Amplifier Module TAM-D 2For more information about tracheal pressure and air flow contact Harvard Apparatus technical support. Housing for Hugo Sachs Electronik-Harvard Apparatus TAM Amplifiers PLUGSYS Case Type Slots Dimensions, H x W x D ST1 73-0045 603 20 132 x 483 x 435 mm (5.2 x 19 x 17.1 in) ST1 73-1521 601 10 150 x 235 x 420 mm (5.9 x 9.25 x 16.5 in) ST1 73-1523 609 43 160 x 160 x 250 mm (6.3 x 6.3 x 9.8 in)

3 HSE-HA Type 609 Minicase is not modular, amplifier units are factory installed.

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ISO510A Transducer Amplifier Transducer Amplifier Plug In (TAPi)

Panlab's ISO510A Transducer Amplifier Harvard Apparatus Ltd TAPi

• High gain differential AC/DC amplifier The Transducer Amplifier Plug In module (or TAPi) has been • Includes adjustable filter for suppression of designed to interface the Harvard Apparatus Ltd range of background noise transducers to either an iWorx or ADInstruments (PowerLab) data acquisition system. • Transducer balance allows a fine adjustment of the signal baseline • The TAPi is powered by either the iWorx or ADI system • Allows external monitoring of the output signal • Three position filter allows for smoothing out of • On-board analog to digital conversion integrated into vibrations from oxygenating solutions, during force Power Supply Box measurement applications • A simple single USB Connection to a PC • Compatible with a wide array of transducers • Ideal for use in pressure, force or respiration research areas Specifications Power Requirements Received from host interface unit Full bridge or single-ended. Specifications Input x1, x100, x200 selectable Gain 0 to 2,000 Gain ±1.5 V Input Impedance 1.5 kΩ DC Offset Control 3 position Output Impedance < 100 Ω Filter 5 V Feed Power 18 VDC Voltage, Front Panel 7-pin binder type Output Voltage 10 V Input Socket Interface Cable iWorx or Powerlab® Transducer Power Supply 10 VDC Output Band Frequency 0 to 5 KHz VITAL SIGNS VITAL Filters >3 Hz or >20 Hz Order # Product Filter AC 0.16 Hz ST1 50-9710 Transducer Amplifier for ADI/iWorx Certification CE Compliance Pressure Transducers: ST1 50-8953 Blood Pressure Transducer Plethysmograph: Order # Model Product ST1 50-8093 Finger Plethysmograph ST1 76-0627 ISO510A ISO510A Transducer Amplifier Cables: ST1 76-0140 BR4740A Power Supply Box for up to 4 Amplifiers ISO510A ST1 50-9712 Interface cable for iWorx ST1 50-9713 Interface cable for ADInstruments

218 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com BLOOD PRESSURE

Models with different pressure ranges are available. Each model has an application-specific range (range 1) and can be switched to a corresponding SI range (range 2) in Pascal (Pa) or Kilopascal (kPA).

Specifications Model KAL 84 H KAL 84 SH KAL 84 L KAL 84 M Range 1 0 to 199.9 0 to 300.0 0 to 19.99 0 to 199.9

mmHg mmHg mmH2O mmH2O Range 2 0 to 0 to 0 to 199.9 0 to 1960 Pa

26.66 kPa 39.99 kPa mmH2O Linearity ±0.5% FS ±1 digit for mercury models, ±1% FS ±1 digit for water models Hysteresis 0.1% FS Overpressure Limit 200% FS for mercury models 500% FS for water models Response Time TE = 20 ms, time constant can be switched Electronic Pressure Calibrators to 0.1 sec or 1 sec Liquid Mercury Mercury Water Water • Maintenance free precision pressure generation Analog Output 0 to 1 V for 100% nominal range, load resistance • 4 units available: at least 2 kΩ – 0 to 200 mmHg Temperature Range: – 0 to 300 mmHg Nominal +10° to +50°C Operating 0° to +60°C – 0 to 20 mmH2O – 0 to 200 mmH O Pressure 6.5 mm OD for 5 mm ID tubing 2 Connections • Calibration certificate on request Power Supply 9 V rechargeable battery, mains adapter Dimensions, 100 x 260 x 180 mm (3.9 x 10.2 x 7.1 in) The calibrator KAL 84 is used for calibrating pressure sensors. It H x W x D represents a combination of a pressure generator (hand pump) Weight Approx. 3 kg (6.6 lb) and a pressure meter with digital display. The instrument provides Optional Certificate Linearity test certificate, DKD (German calibration a simple means for testing and calibrating both pressure sensors service, see below) and complete pressure measuring equipment. High accuracy Applications Blood Blood Low-Range Differential and excellent reproducibility together with an especially rugged Pressure Pressure Pressure Transducers construction provide the unit with all the properties required for Transducers Transducers laboratory applications. Order # for ST1 73-0012 ST1 73-0014 ST1 73-0016 ST1 73-0018 115 VAC, 60 Hz After the unit has been switched on and connected to the pressure Order # for ST1 73-0013 ST1 73-0015 ST1 73-0017 ST1 73-0019 sensor to be calibrated (test object), the required pressure is set 230 VAC, 50 Hz with the small hand-wheel. The built-in pressure meter measures the set pressure accurately and indicates it in digital form. Since the generated pressure is identical at the built-in pressure meter and at the test object, the pressure measured by the test object corresponds exactly to the pressure indicated by the KAL 84.

Manual Pressure Calibrator

Manual pressure calibration kit from Hugo Sachs makes use of a one-way valve in bulb and is appropriate for blood pressure calibration for both arterial and venous pressure ranges. VITAL SIGNS

Order # Product ST1 73-4479 Manual Pressure Calibrator

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Standard Unit for NIBP 76-0174 (LE5002) • Includes all components of 76-0173 plus • Raw data internal memory (up to 4,000 successive trials) Complete Unit for NIBP 76-0175 (LE5007) • Includes all components of 76-0174 plus • Statistical calculations (average, deviation, number of samples for all animals) • Connection to the Heater and Scanner device for automatic measurement of up to 12 animals Accessories • SeDaCom Software • Chart™ Software for monitoring of pressure and pulse wave signals • Single or multiple animal heating units • Pulse Transducer & Cuff • Specimen holders Non-Invasive Blood Pressure System for Rodents The Panlab NIPB system provides an easy and reliable technique to Key Features measure systemic blood pressure and cardiovascular parameters in rodents without any invasive catheterization. • Total reliability to realize consecutive measurements on the same animal The pulse signal level (heart rate) is continuously monitored on • Analog signal output for recording cuff pressure and the LCD display while an internal pressure transducer is constantly pulse signals in a PC measuring the current pressure applied on the cuff. Systolic and diastolic blood pressures are displayed after a series of automatic • Automated deflation driven separately for each animal processes finish. (minimize tail lesions) A warm environment is critical for accurate blood pressure • Automated cuff inflation/deflation at a very constant rate measurement. For optimal conditions the Panlab Warming Chamber • The same system can be used for mouse/rat/dog or the Automatic Heater & Scanner provides a comfortable heated • Real values provided (without any linear regression environment. The requirement of a warm environment for the calculation) animals is critical for accurate blood pressure measurements. To • Easily traceable data (using data acquisition software) provide adequate conditions for NIBP measurement, the system can be used in association with a warming chamber which provides • Parameters evaluated can be visualized on-line on the a comfortable and heated environment necessary to produce digital display peripheral vasodilatation and isolate the animal from external noise. Parameters Measured • Systolic blood pressure Specifications • Diastolic blood pressure VITAL SIGNS VITAL Dimensions LE5001 360 (W) x 340 (D) x 120 (H) mm • Mean blood pressure Control Unit • Heart rate Dimensions LE5002 and 60 (W) x 340 (D) x 170 (H) mm LE5007 Control Units Computer Requirements PC (Windows 95, 98, ME, NT, 2000, XP and Vista Included Components: (only if SeDaCom is used) Power Supply 220/110 VAC, 50/60 Hz Basic Unit for NIBP 76-0173 (LE5001) Certifications CE Compliant • Control unit with LCD display • Pressure and pulse BNC analog signal output • RS-232 serial port • Cables • Spare fuses • Instruction manual

Note: Pulse Transducer & Cuff and SeDaCom software must be ordered separately.

220 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com BLOOD PRESSURE

Order # Model Product Blood Pressure Tranducer ST1 76-0173 LE5001 Basic Unit for NIBP with RS-232 Serial Port. Cuff and Transducer have to be ordered separately. ST1 76-0174 LE5002 Standard Unit for NIBP with Memory and RS-232 Serial Port. Cuff and Transducer have to be ordered separately. ST1 76-0175 LE5007 Complete Unit for NIBP with Scheduled Data Acquisition (up to 12 Animals) Memory and RS-232 Serial Port. Cuff and Transducer have to be ordered separately. Accessories ST1 76-0406 - SeDaCom Software* ST1 76-0466 NIBPchart Panlab NIBP system software for the traceability and graphical validation of the data supplied by either LE5001, LE5002 or LE5007. Order # Model Product ST1 76-0608 - RS-232/USB Converter ST1 76-0012 LE5160M Pulse Transducer & Cuff for Mice and Rats up to 150 Grams ST1 76-0177 LE5090 Electronic Rat Simulator ST1 76-0013 LE5160R Pulse Transducer & Cuff for Rat ST1 76-0178 LE5610 Heater for Single Animal ST1 76-0014 LE5015 Dog Pulse Transducer (18 mm Diameter) ST1 76-0179 LE5650-6 Automatic Heater & Scanner for Six Rats or Six Mice ST1 76-0015 LE5012 Pressure Cuff for Dog ST1 76-0401 LE5095 Transducer & Holder Fixing Plate Options ST1 76-0432 LE5160-MM Pulse Transducer & Cuff for Mice (Diameter ST1 76-0016 MB5160R Set of 100 Spare Membranes for Rat Cuff 6 mm) ST1 76-0017 MB5160M Set of 10 Spare Membranes for Mouse Cuff ST1 76-0183 LE5016 Mouse Holder, Small, Approximately ST1 76-0018 LE5180M Mouse Cuff 15 to 25 grams ST1 76-0019 LE5180R Rat Cuff ST1 76-0184 LE5018 Mouse Holder, Large, Approximately 25 to 40 grams ST1 76-0185 LE5020 Rat Holder (150 grams) ST1 76-0186 LE5022 Rat Holder (250 grams) ST1 76-0187 LE5024 Rat Holder (400 grams) ST1 76-0188 LE5025 Rat Holder (500 grams) *Note: Requires ST1 76-0608 RS-232/USB adapter.

Citations: Alfany-Fernandez I et al. (2009) Therapeutic Targets in Liver Transplantation: Angiotensin II in Nonsteatotic Grafts and Angiotensin-(1–7) in Steatotic Grafts. Am. J. Transplantation. 9(3)-439- 451. (LE5001, Spain) Choi JH et al. (2009) Comparative antihypertensive activities of losartan and HM70186 in rats with hepatic dysfunction. Arch. Pharmacal Res. 32(7):1005-1011. (LE5002, rat, Korea) Kim DW et al. (2009) Germinated Buckwheat extract decreases blood pressure and nitrotyrosine immunoreactivity in aortic endothelial cells in spontaneously hypertensive rats. Phytotherapy Research. 23(7):993-998 (Rat, LE5002, South Korea). Ramalho FS et al. (2009) Are Angiotensin II Receptor Antagonists Useful Strategies in Steatotic and Nonsteatotic Livers in Conditions of Partial Hepatectomy under Ischemia-Reperfusion? J. Pharmacol. Exp. Ther. 329:130-140. (LE5001, Spain) Bhandari U et al. (2008) Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. Fitoterapia. 79(5): 351- 355. (LE5001, diabetic rat, India) Canicer R et al. (2008) Simvastatin reverses the hypertension of heterozygous mice lacking VITAL SIGNS cystathionine _-synthase and apolipoprotein A-I. Naunyn-Schmiedeberg’s Archives of Harvard Apparatus Spotlight On: NIBP Pharmacology. 377(1):35-43. (Mouse, LE5002, Spain) Casillas-Ramirez A et al. (2008) Inhibition of angiotensin II action protects rat steatotic livers against ischemia-reperfusion injury. Critical Care Medicine. 36(4):1256-1266 (LE5001, Zucker rats, Featured NIBP Article: Rosuvastatin added Spain) to standard heart failure therapy improves cardiac remodeling in heart failure rats with preserved ejection fraction

Dulcenombre Gomez-Garre, et. al (2010)

Scan this QR code to view the article:

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Order # Product ST1 72-7073 Mouse Holder SC1000 NIBP for Mouse ST1 72-7073 SC1000 Blood Pressure Analysis System for Mice, 85 to 240 VAC, 50/60 Hz* ST1 72-7074 SC1000 Blood Pressure Analysis System for Rats, 85 to 240 VAC, 50/60 Hz* ST1 72-7075 Additional Mouse Platform with Size 1 Mouse Holder and CAT5 Cable ST1 72-7076 Additional Rat Platform with Size 1 Rat Holder and CAT5 Cable ST1 72-7078 SC1000 Comm for Windows® Software Accessories ST1 72-7084 Specimen Holder for Mice, Size 1, for Mice Up to 30 Grams ST1 72-7085 Specimen Holder for Mice, Size 2, for Mice 30 to 45 Grams ST1 72-7086 Specimen Holder for Mice, Size 3, for Mice 45 to 60 Grams ST1 72-7087 Specimen Holder for Mice, Size 4, for Mice Over 60 Grams ST1 72-7102 Specimen Holder for Rats, Size 1, for Rats Up to 250 Grams ST1 72-7103 Specimen Holder for Rats, Size 2, for Rats 250 to 400 Grams ST1 72-7104 Specimen Holder for Rats, Size 3, for Rats 400 to 550 Grams ST1 72-7105 Specimen Holder for Rats, Size 4, for Rats 550 to 700 Grams ST1 72-7106 Specimen Holder for Rats, Size 5, for Rats 700 to 850 Grams ST1 72-7107 Specimen Holder for Rats, Size 6, for Rats 800 to 1000 Grams

ST1 72-7073 SC1000 NIBP for Mouse *Note: All units are supplied with USA standard power cords. with ST1 72-7075 Rat Platform

SC1000 Blood Pressure Analysis System for Mice and Rats (NIBP)

The SC1000 is a non-invasive tail cuff system dedicated to detecting blood pressure in mice or rats. The SC1000 can be used for one or two animals and includes restrainers, heater and software. • Single or dual channel, non-invasive, tail-cuff blood pressure analysis system • Fast, easy, accurate results for one or two animals • Measures systolic, diastolic, mean arterial pressure, and pulse rate • Results correlate with telemetry • Software operated • Easy to assemble, use, and clean VITAL SIGNS VITAL • One system can accommodate mice and rats. For use with mice and rats from neonatal to over 1,000 grams • Sensory assembly includes “V-notch” stabilizer and single tail-cuff Harvard Apparatus Spotlight On: NIBP • All metal construction with baked epoxy finish • Intra-arterial option available Featured NIBP Article: Cardiomyocyte SC1000 Blood Pressure Analysis System Includes: specific steatosis, and modest cardiac dysfunction • Master Control Unit Wang, H., et. al (2013) • Mouse or Rat Specimen Platform • Size 1 Mouse or Rat Holders • Software Scan this QR code to view the article: Additional platform and holders are available for individual purchase.

222 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com BLOOD PRESSURE

MC4000 Blood Pressure Analysis System for Order # Product Multiple Mice and Rats (NIBP) ST1 72-7080 MC4000 Blood Pressure Analysis System for Mice ST1 72-7081 MC4000 Blood Pressure Analysis System for Rats The MC4000 Multi Channel Blood Pressure Analysis System is a ST1 72-7082 Additional Specimen Platform for Mice, Includes Multi-Channel non-invasive instrument designed to help researchers efficiently Specimen Platform, Four Size 1 Mouse Holders, Necessary and effectively obtain accurate blood pressure measurements on Power and Communications Cables and Accessory Kit mice and rats. ST1 72-7083 Additional Specimen Platform for Rats, Includes Multi-Channel Specimen Platform, Four Size 1 Rat Holders, Necessary Power • Tail cuff system for mouse blood pressure and rat blood and Communications Cables and Accessory Kit pressure Accessories • Four to eight channels ST1 72-7084 Specimen Holder for Mice, Size 1, for Mice up to 30 g • Computer controlled, software operated ST1 72-7085 Specimen Holder for Mice, Size 2, for Mice 30 to 45 g • Easy to assemble, clean, and maintain ST1 72-7086 Specimen Holder for Mice, Size 3, for Mice 45 to 60 g ST1 72-7087 Specimen Holder for Mice, Size 4, for Mice over 60 g • Results in systolic, diastolic, mean arterial pressure, ST1 72-7102 Specimen Holder for Rats, Size 1, for Rats up to 250 g and pulse rate ST1 72-7103 Specimen Holder for Rats, Size 2, for Rats 250 to 400 g • Waveforms display measurements in real time ST1 72-7104 Specimen Holder for Rats, Size 3, for Rats 400 to 550 g • Unique “V-notch” sensory assembly ST1 72-7105 Specimen Holder for Rats, Size 4, for Rats 550 to 700 g • Rodent holders secure untrained animals ST1 72-7106 Specimen Holder for Rats, Size 5, for Rats 700 to 850 g • Holders specially designed to reduce stress ST1 72-7107 Specimen Holder for Rats, Size 6, for Rats 800 to 1000 g • Systolic and diastolic pressures are measured, not calculated • Obtains fifteen measurements per mouse or rat in less than fifteen minutes

MC4000 Components • Specimen Platform: Mouse or Rat

• Specimen Holders: Size 1 Mouse or Rat Harvard Apparatus Spotlight On: NIBP VITAL SIGNS • Specimen Tray • Power/Utility Unit Featured NIBP Article: Renin Inhibition • MC4000 Software Attenuates Insulin Resistance, Oxidative Additional platform and holders are available for individual Stess, and Pancreatic Remodeling in the purchase. Transgenic Ren2 Rat

Habibi, J., et. al (2008) Specifications Dimensions, H x W x D: Scan this QR code Mouse Platform 10.2 x 43.2 x 27.9 cm (4 x 17 x 11 in) to view the article: Rat Platform 10.2 x 50.8 x 35.6 cm (4 x 20 x 14 in) Power 85 to 240 VAC, 50/50 Hz*

*All units are supplied with USA standard power cords

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 223 PHYSIOLOGICAL MONITORING SYSTEMS

BLOOD FLOW, BLOOD PRESSURE & ECG RESEARCH GRADE MONITORING SYSTEMS Introducing packaged system options for the measurement of blood flow while simultaneously monitoring blood pressure and single- or multi-lead ECG from rodent to large animal subjects. Choose a research grade system when you wish to record and collect data in an automated fashion as opposed to recording values by hand every few minutes. Veterinary-grade surgical monitors often do not have a user-friendly data output and are not always suitable for the application at hand. Using a data acquisition system such as PowerLab (pages 198-201), the analog output of the Research Grade Monitoring system can be converted to digital data through the LabChart™ software.

Building a System

For a basic system, we recommend a smaller amplifier housing will plug into the case now or for future expansion. For example, the (PLUGSYS 601 Case, 10 Slot Units). For an advanced system with TTFM is 4 SU wide, while the TAM-A and ECGA modules are each upgradable or multi-animal functionality a larger amplifier housing is only 2 SU wide. A 10 SU case can hold 1 TTFM and 3 TAM-A amplifiers recommended (PLUGSYS 603 Case, 20 Slot Units). or 2 TTFM and 1 TAM-A amplifier. For the researcher who wishes to have Blood Flow, Blood Pressure, and 12-Lead ECG Measurement, the Slot Units (SU) are the designation of the width of the various advanced system case would be chosen as the setup would require a PLUGSYS Modules available to fit into the PLUGSYS case options. minimum of 12 SU. Each case has a fixed capacity (10 or 20 SU) and the appropriate case is chosen based on the total number of modules the researcher All package options can be interfaced with a data acquisition system.

STEP 1: Choose your PLUGSYS Amplifier Housing VITAL SIGNS VITAL

ST1 73-0045 PLUGSYS 603 Case, 20 Slot Units ST1 73-1521 PLUGSYS 601 Case, 10 Slot Units (Advanced) (Basic)

STEP 2: Choose your add-on options for a customized system from the following pages

Blood Flow: Pressure Blood Pressure: 6 Lead ECG Blood Pressure: 12 Lead ECG

224 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com PHYSIOLOGICAL MONITORING SYSTEMS

Option for Blood Flow and Pressure Option for 6-Lead Einthoven Leads I, II, III, aVI, aVr, and aVf Order # Product ST1 73-4536 Option for Blood Flow and Pressure Order # Product Includes: ST1 73-4537 6-Lead Einthoven Leads I, II, III, aVI, aVr, and aVf • TTFM Transit Time Flowmeter Module (4SU) Includes: with Flowprobe Extension Cable and BNC Cable, 2 m (6.6 ft) • EGM Module (2 SU) • TAM-A Transducer Amplifier Module with BNC Cable, 2 m (6.6 ft) • BNC Output, 6-fold (1 SU) See page 227 for available Flowprobes • BNC Cable (6 are required) See page 228 for available Blood Pressure Transducers Reusable Disposable Electrodes* Electrodes 28 Gauge Needle Tabs Snaps Order # ST1 72-5740 ST1 72-7092 ST1 72-7090 Supplied as Pkg. of 12 Pkg. of 100 Pkg. of 60 Qty. Required 1 Pkg. 1 Pkg. 1 Pkg. Required Adapter N/A Alligator Clip Pinch Clamp Order # – ST1 60-2394 ST1 73-3383 Supplied as – Pkg. of 10 Each Qty. Required – 1 Pkg. 4 Direct Connection Cable to Amplifier Small Animal ST1 73-1786 N/A N/A Large Animal ST1 73-3381 ST1 73-3381 ST1 73-3381

*Small animal cable for disposable electrodes are not available. This type of electrode is difficult or impossible to be placed on such species. For Small Animals the total monitoring cable lengths is 2.00 m the ending leads have a length of 30 cm. VITAL SIGNS For Large Animals the total monitoring cable lengths is 2.50 m the ending Option for Single Lead ECG (Lead II) leads have a length of 75 cm

Order # Product Order # Product ST1 73-0149 Single Lead ECG (Lead II) Accessories for Reusable Needles Includes: ST1 72-1872 Needle Cleaning Kit • ECGA Module (2 SU), supplied with Needle electrodes ST1 72-1875 Cleaning Wires for 28 to 30 G Needles, pkg. of 10 for small animal ECG with BNC Cables, 2 m (6.6 ft) ST17 2-1880 Cleaning Concentrate, 500 ml For use with SNAP electrodes for large animals (see page 229 for electrode options): Accessories for Disposable Electrodes • Connection Cable to ECGA Amplifier with 4 mm Banana Jacks ST1 60-2395 Preparatory Pads (70% Isopropanol), pkg. of 1000 • 4 mm Banana to Standard Snap, pkg. of 2 See page 229 for Additional Large Animal Electrodes and Electrode Accessories

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 225 PHYSIOLOGICAL MONITORING SYSTEMS

Options for 12-Lead Einthoven (Leads I, II, III, aVI, Options for Second Flowmeter Channel aVr, and aVf) and Wilson Leads (V1-V6) Order # Product Order # Product ST1 73-0146 TTFM Transit Time Flowmeter Module (4SU) ST1 73-4538 12-Lead Einthoven (Leads I, II, III, aVI, aVr, and aVf) with Flowprobe Extension Cable and BNC Cable, 2m and Wilson Leads (V1-V6) Additional items required: Includes: • Flowprobe of your choice (see page 227) • EGM Module (2 SU) Optional Accessories • WLA Module (2 SU) ST1 73-4102 15-Pin shielded exension cable, 1.5 m • Input box for 12-Lead ECG • Connection Cable for EGM for Needle or Tab/Snap Fastener • Connection Cable for WLA for Needle or Tab/Snap Fastener • BNC Output, 6-fold (2 are required, 1 SU each) • BNC Cable (12 are required)

Choose the appropriate Electrodes and Adapters from the table below:

Reusable Disposable Electrodes* Electrodes 28 Gauge Needle Tabs Snaps Order # ST1 72-5740 ST1 72-7092 ST1 72-7090 Supplied as Pkg. of 12 Pkg. of 100 Pkg. of 60

VITAL SIGNS VITAL Qty. Required 1 Pkg. 1 Pkg. 1 Pkg. Required Adapter N/A Alligator Clip Pinch Clamp Order # – ST1 60-2394 ST1 73-3383 Supplied as – Pkg. of 10 Each Qty. Required – 1 Pkg. 10 Options for Additional Blood Pressure Channel *Small animals cables for disposable electrodes are not available. This type of electrode is difficult or impossible to be placed on such species. Order # Product For Small Animals the total monitoring cable lengths is 2.00 m the ending ST1 73-0065 TAM-A transducer amplifier module with BNC cable, 2 m leads have a length of 30 cm. Additional items required: For Large Animals the total monitoring cable lengths is 2.50 m the ending • Pressure Transducer of your choice, see table (see page 228) leads have a length of 75 cm

Order # Product Accessories for Reusable Needles ST1 72-1872 Needle Cleaning Kit ST1 72-1875 Cleaning Wires for 28 to 30 G Needles, pkg. of 10 NOTE: Do you need more than just ST17 2-1880 Cleaning Concentrate, 500 ml Flow, Pressure, and ECG? For our full Accessories for Disposable Electrodes range of amplifier options, please contact ST1 60-2395 Preparatory Pads (70% Isopropanol), pkg. of 1000 Technical Support at 800-547-6776

226 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com TRANSDUCERS

Flow Probe Options for the PLUGSYS TTFM Transit Time Flowmeter Module

Probe Body

Microcirculation Probes (V-Series) Standard Probes (S-Series) Standard Probes (R-Series) 2 to 20 mm 1 to 1.5 mm 0.5 to 0.7 mm for direct volume flow measurement in vessels down to 250 µm in For direct measurement of volume flow for For direct measurement of volume flow for rat or mouse. vessels from 2 to 20 mm diameter. These vessels from 1 to 1.5 mm diameter. These probes have the transducers positioned at probes have the transducers positioned at an 60° angle to the vessel. This reduces the an 45° angle to the vessel. flow probe body size and reflector width for placement of the probe in applications where space is limited.

Order # Probe Type Diameter OD Vessel Resolution Range ml/min Probe Probe Cable Cable Acute ml/min Length Width Length Exit Sc. Low Sc. Norm Max V-Series - with Flexible Handle ST1 73-4066 MC0.5VB-HSE 0.5 mm 0.25-0.5 0.05 2.5 10 50 6.5 mm 4 mm 60 cm Back ST1 73-4067 MC0.7VB-HSE 0.7 mm 0.35-0.7 0.075 5 20 100 7.6 mm 3.5 mm 60 cm Back S-Series - J Reflector with Slide Cover ST1 73-4068 MC2PSB-HSE 2 mm 1.5 - 2.0 0.1 25 100 500 8.7 mm 3.3 mm 100 cm Back ST1 73-4069 MC2PSS-HSE 2 mm 1.5 - 2.0 0.1 25 100 500 8.7 mm 3.3 mm 100 cm Side ST1 73-4070 MC2.5PSB-HSE 2.5 mm 1.8 - 2.5 0.1 25 100 500 8.7 mm 3.3 mm 100 cm Back ST1 73-4071 MC2.5PSS-HSE 2.5 mm 1.8 - 2.5 0.1 25 100 500 8.7 mm 3.3 mm 100 cm Side ST1 73-4072 MC2.5PSL-HSE 2.5 mm 1.8 - 2.5 0.1 25 100 500 8.7 mm 3.3 mm 100 cm Lateral S-Series - L Reflector with Slide Cover ST1 73-4073 MC3PSB-HSE 3 mm 2.5 - 3.7 0.4 50 200 1L 9 mm 5 mm 100 cm Back ST1 73-4074 MC3PSS-HSE 3 mm 2.5 - 3.7 0.4 50 200 1L 9 mm 5 mm 100 cm Side ST1 73-4075 MC4PSB-HSE 4 mm 3.3 - 4.4 0.8 100 400 2L 13.3 mm 6 mm 100 cm Back ST1 73-4076 MC4PSS-HSE 4 mm 3.3 - 4.4 0.8 100 400 2L 13.3 mm 6 mm 100 cm Side ST1 73-4077 MC6PSB-HSE 6 mm 4.4 - 6.6 2 2 50 1L 5L 13.5 mm 6.7 mm 100 cm Back ST1 73-4078 MC6PSS-HSE 6 mm 4.4 - 6.6 2 2 50 1L 5L 13.5 mm 6.7 mm 100 cm Side ST1 73-4079 MC8PSB-HSE 8 mm 6.6 - 8.8 4 500 2L 10L 18.8 mm 7.5 mm 100 cm Back ST1 73-4080 MC8PSS-HSE 8 mm 6.6 - 8.8 4 500 2L 10L 18.8 mm 7.5 mm 100 cm Side

ST1 73-4081 MC10PSB-HSE 10 mm 8.3 - 11.0 8 500 2L 10L 18.7 mm 8.5 mm 100 cm Back VITAL SIGNS ST1 73-4082 MC10PSS-HSE 10 mm 8.3 - 11.0 8 500 2L 10L 18.7 mm 8.5 mm 100 cm Side ST1 73-4083 MC12PSB-HSE 12 mm 9.8 - 13 8 1L 4L 20L 22.5 mm 8.5 mm 100 cm Back ST1 73-4084 MC12PSS-HSE 12 mm 9.8 - 13 8 1L 4L 20L 22.5 mm 8.5 mm 100 cm Side ST1 73-4085 MC14PSB-HSE 14 mm 11.3 - 15.0 16 1L 4L 20L 26.2 mm 8.5 mm 100 cm Back ST1 73-4086 MC14PSS-HSE 14 mm 11.3 - 15.0 16 1L 4L 20L 26.2 mm 8.5 mm 100 cm Side ST1 73-4087 MC16PSB-HSE 16 mm 13.3 - 17.7 20 2.5L 10L 50L 36 mm 10 mm 100 cm Back ST1 73-4088 MC16PSS-HSE 16 mm 13.3 - 17.7 20 2.5L 10L 50L 36 mm 10 mm 100 cm Side ST1 73-4089 MC20PSB-HSE 20 mm 16.0 - 21.0 40 2.5L 10L 50L 31 mm 9 mm 100 cm Back ST1 73-4090 MC20PSS-HSE 20 mm 16.0 - 21.0 40 2.5L 10L 50L 31 mm 9 mm 100 cm Side R-Series - J Reflector with Slide Cover ST1 73-4091 MC1PRB-HSE 1 mm 0.7 -1.2 0.05 5 20 100 6.5 mm 4 mm 60 cm Back ST1 73-4092 MC1PRS-HSE 1 mm 0.7 -1.2 0.05 5 20 100 6.5 mm 4 mm 60 cm Side ST1 73-4093 MC1.5PRB-HSE 1.5 mm 1.2 - 1.8 0.075 10 40 200 7.6 mm 3.5 mm 60 cm Back

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 227 TRANSDUCERS

Blood Pressure Transducer Options for use with the PLUGSYS TAM-A Amplifier Module

Order # Model Description Pressure Range Additional Specifications (mmHg) Items Required ST1 73-3862 APT300 Reusable Pressure Transducer f/ TAM Amplifier Cable -300 to +300 ST1 73-3869 Holder f/APT300 see page 210 ST1 76-4254 APT300, Sterile Replacement Transducer Head, pkg. of 1 -300 to +300 ST1 73-3860 Interface Cable for see page 210 Sterile APT300 to TAM Amplifier ST1 76-0582 TRA021HS Reusable Research Pressure Transducer* -50 to +300 - see page 211 ST1 72-4297 DTXPlus Sterile Disposable Pressure Transducer, with TAM -50 to +300 - see page 212 Interface Cable, pack of 10* ST1 88-0360 PRESS-S Sterile Disposable Pressure Transducer, pack of 10 -300 to +300 (�2%) ST1 88-0367 Interface Cable see page 211 (-7 to 75 PSI)* to TAM Amplifier ST1 73-0020 P75 Reusable Venous Blood Pressure Transducer* -75 to +75 ST1 73-0096 3-Way Stopcock see page 213 ST1 73-0097 1-Way Stopcock

*Stopcocks sold separately. See Accessories. VITAL SIGNS VITAL

Order # Product Accessories ST1 75-0039 3-way FLL to MLL with port covers, sterile, box of 50 ST1 75-0030 1-way FLL to MLL with port covers, sterile, box of 50 ST1 73-0096 3-way metal reusable stopcock FLL/FLL/MLL (non-rotating), pkg. of 1 ST1 73-0097 1-way metal reusable stopcock FLL/FLL (non-rotating), pkg. of 1 ST1 72-2662 3-way stopcock, FLL/FLL/MLL (rotating), pkg. of 25 ST1 72-8326 1-way stopcock, FLL/MLL (rotating), pkg. of 25 ST1 72-4479 Manual Pressure Calibration Kit

228 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com ELECTRODES

Disposable ECG Electrodes

Order # Description Diameter Supplied As Features

7 ST1 72-7093 Solid Gel General Purpose Electrode 1 ⁄8 in Pkg. of 60 • Suitable for all types of studies (48 mm) (5/Strip) • Solid gel for improved adhesion and application

7 ST1 72-7094 Wet Gel General Purpose Electrode 1 ⁄8 in Pkg. of 60 • Suitable for all types of studies (48 mm) (5/Strip) • Wet gel for quick reading and increased signal stability

1 ST1 72-7095 Disposable Foam Electrode 1 ⁄2 in Pkg. of 60 • Ag/AgCl high chloride wet gel for fast, (38 mm) (5/Strip) clear traces • For active subjects, no movement artifact • Latex free/hypoallergenic

7 ST1 72-7096 Disposable Foam Electrode 1 ⁄8 in. (48mm) Pkg. of 60 • Ag/AgCl high chloride wet gel for fast, (1/Strip) clear traces • For active subjects, no movement artifact • Latex free/hypoallergenic

7 ST1 72-7092 Ag/AgCl Solid Gel Tab 1 x ⁄8 in Pkg. of 100 • Resting ECG (23 x 24 mm) (10/Strip) • Non-Echo

ST1 72-7090 Aggressive Adhesive Small 1.0 in2 Pkg. of 30 • Small size for easy placement on Disposable Electrode (2.5 cm2) (3/Strip) difficult locations • Hypoallergenic • Comfortable cloth base • Ag/AgCl for clear signal • ECG and EMG • Superior adhesion VITAL SIGNS • Solid gel ST1 72-7091 Gentle Adhesive Small 0.78 in2 Pkg. of 60 • Small size for easy placement on Disposable Electrode (20 mm2) (3/Strip) difficult locations • Hypoallergenic • Comfortable cloth base • Ag/AgCl for clear signal • ECG and EMG • Gentle solid gel adhesive for sensitive areas

3 ST1 72-7099 Ag/AgCl Diagnostic Electrodes 1 ⁄8 in Pkg. of 1,000 • Resting ECG (35 mm) (10/Strip) • Solid gel • Echo • Can be defibrillated

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 229 ACCESSORIES

ECG Electrode Accessories Non-Disposable Electrodes

Preparatory Pads Order # Product ST1 50-9604 Reusable Suction Cup Electrode, 4 mm Connector These individually packaged, 5.1 x 2.5 cm (2 x 1 in), textured cloth ST1 50-9265 Reusable Ag/AgCl Cup Electrodes, 1 mm Connector pads are soaked with 70% isopropanol solution with pumice. These should be used to prepare the skin to receive both reusable and disposable type electrodes.

Electrode Gel and Applicator

This electrode gel provides a good contact between reusable suction electrodes (ST1 50-9604) or reusable Ag/AgCl cup electrodes (ST1 50-9265) and the skin of subject. Use the gel applicator syringe (ST1 50-8309) for dispensing the small amounts VITAL SIGNS VITAL of gel required.

Order # Product Accessories for Disposable Electrodes ST1 60-2395 Preparatory Pads (70% Isopropanol), Pkg. of 1000 ST1 50-8309 Electrode Gel Applicator Syringe with blunt needle ST1 60-2394 Alligator Clip, Connects to an 4 mm Banana Plug for Tab Electrodes, pkg. of 10 ST1 73-3383 Pinch Clamp Adapter to 4mm Banana Plug for ECG Snap Electrodes, pk 2 ST1 50-5313 Tube of Electrode Gel ST1 50-9273 Small Double-Sided Adhesive Discs to hold reusable Ag/AgCl Cup Electrodes, roll 100

230 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com NEUROSCIENCE

Neuroscience research hinges upon having the utmost quality and precision in your work and in your equipment. Harvard Apparatus is proud to carry a line of stereotax that has long had high quality manufacturing and equipment. As part of our commitment to you and your research we are proud to introduce the Ultraprecise Stereotax. Harvard Apparatus also carries all the associated equipment for your stereotaxic surgery such as decapitators (see page 56), brain matrices, bone drills and artificial CSF.

PRODUCT PAGE

Stereotaxic Frames...... 232-241 NEW Ultra-Precise Stereotaxic Instruments...... 232 NEW Standard Stereotaxic Instruments...... 233 Lab Standard Stereotaxic Instruments...... 234 NEW Rotating Elliptical Stereotaxic Instruments...... 235 Just for Mouse Stereotaxic Instrument...... 236 Just for Mice Stereotaxic Instrument...... 237 Digital Stereotaxic Instruments...... 238 Motorized Sterotaxic Instruments...... 239 NEW Stereotaxic Upgrades...... 240 Large Animal Stereotaxic Instruments...... 241 Stereotaxic Accessories...... 242-248 Mouse and Neonatal Rat Adaptor...... 242 Species Adapters & Ear Bars...... 242-244 NEW Gas Anesthesia Adapters & Accessories...... 245 Stereotaxic Probe Holders...... 246 Surgical Drills...... 247-248 Artificial CSF...... 248 Rodent Brain Matrices...... 249 Heart, Tumor, Spinal Cord Matrices...... 250 Micron Punches...... 250 Nanomite Syring Pump...... 251 NEUROSCIENCE STEREOTAXIC INSTRUMENTS

Ultra-Precise Ultra-Precise New Standard Manipulator Stereotaxic Arm

Ultra-Precise Stereotaxic Instruments Order # Model Product Lab Standard Stereotaxic • Precision like never before ST1 72-6353 51600U Ultra-Precise Lab Standard Stereotaxic for Rats • 10 µm resolution with Rat Adaptor and 18° Ear Bars • Target small brain regions with confidence ST1 72-6349 51650U Ultra-Precise Lab Standard Stereotaxic for Rats with Rat Adaptor and 45° Ear Bars • Upgrade existing manipulators ST1 72-6350 51615U Ultra-Precise Lab Standard Stereotaxic for Mice with Mouse and Neonatal Rat Adaptor and These ultra-precise manipulators offer increased resolution. They Delrin® Ear Bars are ideal for use in rat and mouse stereotaxic surgery where high- ST1 75-0330 51670U Ultra-Precise Lab Standard Stereotaxic for Rats accuracy positioning is required. Up to 80 mm of ventral-dorsal, and Mice with Rat and Mouse Adaptors, medial-lateral and anterior-posterior travel with up to 90° angle 18° and Delrin® Ear Bars adjustment in either the anterior-posterior or medial-lateral planes. ST1 72-6354 51603U Ultra-Precise Dual Lab Standard Stereotaxic for Rats with Rat Adaptor and 18° Ear bars Ultra-precise manipulators are compatible with stereotaxic ST1 72-6352 51653U Ultra-Precise Dual Lab Standard Stereotaxic for instruments including the New Standard (see page 233), Rats with Rat Adaptor and 45° Ear Bars Lab Standard (see page 234), Just for Mouse (see page 236) and ST1 72-6164 51618U Ultra-Precise Dual Lab Standard Stereotaxic for Just for Mice (see page 237). Mice with Mouse and Neonatal Rat Adaptor and Delrin® Ear Bars

NEUROSCIENCE Included Components ST1 75-0331 51673U Ultra-Precise Dual Lab Standard Stereotaxic for Rats and Mice with Rat and Mouse Adaptors, Base, manipulator arm(s), standard probe holder(s) with corner 18° and Delrin® Ear Bars clamp, nose clamp assembly (adaptor) and ear bars. Just for Mouse Stereotaxic Purchase a complete Ultra-Precise Stereotaxic instrument or ST1 72-6165 51730U Ultra-Precise Just for Mouse Stereotaxic upgrade your existing stereotaxic instrument (see page 240). ST1 72-6166 51733U Ultra-Precise Dual Just for Mouse Stereotaxic Just for Mice Stereotaxic ST1 72-6167 51725U Ultra-Precise Just for Mice Stereotaxic Order # Model Product New Standard Stereotaxic Delrin is a registered trademark of E.I. du Pont de Nemours and Company. ST1 72-6348 51500U Ultra-Precise New Standard Stereotaxic for Rats and Mice with Rat and Mouse Adaptors, Dual Tip Rat and Delrin® Mouse Ear Bars NOTE: Upgrade your stereotaxic ST1 72-6351 51503U Ultra-Precise Dual New Standard Stereotaxic for Rats and Mice with Rat and Mouse Adaptors, Dual instrument, see page 240. Tip Rat and Delrin® Mouse Ear Bars

232 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com STEREOTAXIC INSTRUMENTS

New Standard Stereotaxic

New Standard Stereotaxic

New Standard Stereotaxic Instruments Like the classic Lab Standard™, the New Standard Stereotaxic has larger laser engraved vernier scales (accurate to 100 µm), • No U-frame, maximizing operating space 80 mm of ventral-dorsal, medial-lateral and anterior-posterior • Designed for both rats and mice all on the same base travel, absolute lock at 90° ventral-dorsal and brass-bushings for electrical grounding. • Vertical and horizontal adjustment of ear and nose posts accommodates rodents of all sizes Included Components • Scales are laser engraved and accurate to 100 µm Base, manipulator arm(s), standard probe holder(s) with corner • Traditional and non-traumatic rat ear bars clamp, rat and mouse nose clamp assemblies (adaptors), lightweight • Manual, digital, motorized and ultra-precise Delrin® mouse ear bars and dual tip rat ear bars; one side is 18° and versions available the other side is 45°.

The innovative design of the New Standard Stereotaxic Instrument Order # Model Product provides users with the ability to perform surgeries on both mice ST1 72-6335 51500 New Standard Stereotaxic for Rats and Mice and rats all on the same base. ST1 72-6336 51503 Dual New Standard Stereotaxic for Rats and Mice The New Standard Stereotaxic is available in manual, digital ST1 72-6337 51501 New Standard Base without Manipulator Arms (see page 238), motorized (see page 239) and ultra-precise (see page 232) versions.

Maximum Versatility Revolutionary new design has eliminated the U-frame allowing for greater flexibility and access to the animal. The New Standard Stereotaxic Instruments enable you to vertically and horizontally adjust both the ear and nose posts allowing you to accommodate NEUROSCIENCE rodents of all sizes.

NOTE: Upgrade your stereotaxic instrument, see page 240.

Lab Standard is a trademark of Stoelting Co.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 233 STEREOTAXIC INSTRUMENTS

Lab Standard Dual Lab Standard Stereotaxic Stereotaxic

Lab Standard™ Stereotaxic Instruments In addition, a swing joint allows the investigator to conveniently swing the manipulator arm and probe out of the way for performing • Large, easy to read vernier scales a procedure — then reliably return the probe to the same point. • Scales are laser engraved–accurate to 100 µm Included Components • Triple lead screws for fast positioning 80 mm of vertical, lateral and anterior-posterior travel U-frame base, manipulator arm(s), standard probe holder(s) with corner clamp, nose clamp assembly (adaptor) and ear bars. • Absolute lock at 90° (vertical) • Manual, digital, motorized and ultra-precise versions available Order # Model Product ST1 72-4790 51600 Lab Standard Stereotaxic for Rats with Rat Adaptor The Lab Standard™ Stereotaxic Instrument, is ideal for researchers and 18° Ear Bars in need of a versatile, reliable instrument for stereotaxic procedures ST1 72-4791 51650 Lab Standard Stereotaxic for Rats with Rat Adaptor with small animals. Precision alignment when using the Lab and 45° Ear Bars Standard™ ensures accurate placement of electrodes, micropipettes, ST1 72-9568 51615 Lab Standard Stereotaxic for Mice with Mouse and Neonatal Rat Adaptor and Delrin® Ear Bars and other devices. ST1 72-6342 51670 Lab Standard Stereotaxic for Rats and Mice with Rat The time-proven ‘U’-Frame design concept, sturdy construction, and Mouse Adaptors, 18° and Delrin® Ear Bars and adaptability to most model species make this a best choice for ST1 72-4792 51603 Dual Lab Standard Stereotaxic for Rats with Rat a stereotaxic instrument. Adaptor and 18° Ear Bars ST1 72-4793 51653 Dual Lab Standard Stereotaxic for Rats with Rat The Lab Standard™ Stereotaxic is available in manual, digital Adaptor and 45° Ear Bars (see page 238), motorized (see page 239) and ultra-precise ST1 72-9569 51618 Dual Lab Standard Stereotaxic for Mice with Mouse (see page 232) versions. and Neonatal Rat Adaptor and Delrin® Ear Bars ST1 72-6343 51673 Dual Lab Standard Stereotaxic for Rats and Mice Easily Read Scales with Rat and Mouse Adaptors, 18° and Delrin® Ear Bars ST1 72-4796 51601 Lab Standard without Manipulator Arms All scales are oriented to be read easily from the open end of the – Stereotaxic Surgery in the Rat ‘U’. This is the position from which most scientists prefer to work. ST1 72-4240 NEUROSCIENCE The numerals on the scales are larger, and therefore more easily read. The scale lines are laser engraved, to allow finest possible permanent marking of scales on all 3 axes. Precise alignment with facing vernier scales gives accurate resolution to 100 µm.

Versatility of Positioning The manipulator arm controls medial-lateral and ventral-dorsal positioning using exclusive triple lead screws for faster positioning, and anterior-posterior movement via dovetail slide movement, with 80 mm of travel possible in each direction. A universal joint allows the investigator to change the angle of the probe up to 90° in either the anterior-posterior or medial-lateral planes. The improved locking mechanism on the Lab Standard™ will hold any angle position without slippage. And of course, it also provides an Lab Standard is a trademark of Stoelting Co. Delrin is a registered trademark of E.I. du Pont de Nemours and Company. absolute lock at 90° vertical.

234 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com STEREOTAXIC INSTRUMENTS

Easily Read Scales All scales are oriented to be read easily from the open end of the ‘U’. This is the position from which most scientists prefer to work. The numerals on the scales are larger, and therefore more easily read. The scale lines are laser engraved, to allow finest possible permanent marking of scales on all 3 axes. Precise alignment with facing vernier scales gives accurate resolution to 100 µm.

Versatility of Positioning The manipulator arm controls medial-lateral and ventral-dorsal positioning using exclusive triple lead screws for faster positioning, and anterior-posterior movement via dovetail slide movement, with 80 mm of travel possible in each direction. A universal joint allows the investigator to change the angle of the probe up to 90° in either the anterior-posterior or medial-lateral planes. The improved locking mechanism on the Lab Standard™ will hold any angle position without slippage. And of course, it also provides an absolute lock at 90° vertical. In addition, a swing joint allows the investigator to conveniently swing the manipulator arm and probe out of the way for performing a procedure — then reliably return the probe to the same point. The Rotating Elliptical Stereotaxic is available in manual, digital (see page 238), and motorized (see page 239) versions. Included Components Base, manipulator arm(s), standard probe holder with corner clamp, nose clamp assembly (adaptor) and ear bars. Rotating Elliptical Stereotaxic Instruments Order # Model Product • 360° Turntable rotation provides unlimited ST1 72-6391 51600E Rotating Elliptical Stereotaxic for Rats positioning options with Rat Adaptor and 18° Ear Bars • Absolute lock at each 45° position ST1 75-0320 51615E Rotating Elliptical Stereotaxic for Mice with Mouse and Neonatal Rat Adaptor and Delrin® Ear Bars • Accurate to 100 µm ST1 75-0321 51670E Rotating Elliptical Stereotaxic for Rats and Mice with • Classic U-frame design Rat and Mouse Adaptors, 18° and Delrin® Ear Bars ST1 72-6392 51603E Dual Rotating Elliptical Stereotaxic for Rats • Manual, digital and motorized versions available with Rat Adaptor and 18° Ear Bars The Rotating Elliptical Stereotaxic Intruments allow for 360° ST1 75-0322 51618E Dual Rotating Elliptical Stereotaxic for Mice with Mouse and Neonatal Rat Adaptor and rotation of the entire U-frame stereotaxic instrument providing Delrin® Ear Bars researchers with greater accessibility without compromising ST1 75-0323 51673E Dual Rotating Elliptical Stereotaxic for Rats and surgical positioning. A locking screw allows researchers to secure Mice with Rat and Mouse Adaptors, 18° and Delrin® position at 45 degree increments. Ear Bars The rotating capacity can be of major benefit when teaching. Imagine one person performing the surgery with others gathered around. Instead of having students looking over one's shoulders, NOTE: Upgrade your stereotaxic you can unlock the frame and swivel it in their direction. instrument, see page 240. NEUROSCIENCE

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 235 STEREOTAXIC INSTRUMENTS

Dual Manipulator Arms Add another manipulator arm for increased versatility. Often used for electrophysiology studies that requires both recording and stimulation.

Unique, Light Ear Bars Ear bar posts may be independently adjusted in height—a unique feature of this stereotaxic instrument—to level the skull. Ear bars are composed of light Delrin® material with tapered points, non-invasive rubber pads or jaw holder cuffs. Laser engraved scales show the vertical positions of the ear bars. Model organisms with soft skulls, such as the mouse and the neonatal rat, are difficult to secure firmly in a traditional stereotaxic instrument. The stainless steel ear bars used for adult rats are too heavy to provide a secure hold without compressing the sides of the skull inward (which closes the airways and impedes blood flow).

Included Components Base, manipulator arm(s), standard probe holder(s) with corner clamp, Delrin® nose clamp assembly and Delrin® ear bars.

Order # Model Product ST1 72-9564 51730 Just for Mouse Stereotaxic ST1 72-9565 51733 Dual Just for Mouse Stereotaxic Just For Mouse™ Stereotaxic Instruments

• 25 x 25 cm footprint NOTE: Upgrade your stereotaxic • Ear and tooth bar post height adjustment to instrument, see page 240. accommodate animals between 10-75 grams • Delrin® ear bars; tapered points on one end and rubber pads on the other • Triple lead screw in manipulator arm for fast positioning • Accurate to 100 µm • Manual, digital, motorized and ultra-precise versions available

The Just For Mouse™ Stereotaxic Instrument was specifically developed for the expanding growth of research being conducted in laboratories using knock-out and transgenic mice. This stereotaxic instrument is ideal for researchers in need of a versatile, reliable instrument for stereotaxic procedures with mice and other small rodents. Precision alignment when using the Just For Mouse™ ensures accurate placement of electrodes, micropipettes, cannula, and other devices. Just For Mouse™ is the only instrument built especially for mice, and offers several advantages over competing NEUROSCIENCE “made for rat” instruments. The Just For Mouse™ Stereotaxic is available in manual, digital (see page 238), motorized (see page 239) and ultra-precise (see page 232) versions.

Small Footprint The small size, one of the smallest on the market, is ideal for laboratories with small spaces or for use in surgical suites that require transportation of equipment to and from surgical facilities.

Just for Mouse is a trademark of Stoelting Co. Delrin is a registered trademark of E.I. du Pont de Nemours and Company.

236 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com STEREOTAXIC INSTRUMENTS

Dual Workstations Two stereotaxic instruments on a single base. The base is 10 in x 10 in and has two ear bar and tooth holder slots located on each side. A tooth bar and nose clamp secures the nose. A single manipulator arm controls medial-lateral and dorsal-ventral positioning via triple-lead screws, and anterior-posterior movement via dovetail slide movement, with 80 mm of travel possible in each direction, allowing access to both ear bar locations.

Unique, Light Ear Bars Ear bar posts may be independently adjusted in height—a unique feature of this stereotaxic instrument—to level the skull. Ear bars are composed of light Delrin® material with tapered points, non-invasive rubber pads or jaw holder cuffs. Laser engraved scales show the vertical positions of the ear bars. Model organisms with soft skulls, such as the mouse and the neonatal rat, are difficult to secure firmly in a traditional stereotaxic instrument. The stainless steel ear bars used for adult rats are too heavy to provide a secure hold without compressing the sides of the skull inward (which closes the airways and impedes blood flow.) Further, the neonatal rat pup has no external opening of the auditory canal for inserting the ear Just For Mice™ Stereotaxic Instrument bar points. Included Components • Ideal for neonatal rats and mice • Dual workstations Base, manipulator arm, standard probe holder with corner clamp, Delrin® nose clamp assembly and Delrin® ear bars. • Accurate to 100 µm • Ear and tooth bar post height adjustment to accomodate animals between 10-75 grams Order # Model Product ST1 72-6049 51725 Just for Mice Stereotaxic • Delrin® ear bars; tapered points on one end and rubber pads on the other • Triple lead screw in manipulator arm for fast positioning • Manual, digital, motorized and ultra-precise NOTE: Upgrade your stereotaxic versions available instrument, see page 240.

The Just For Mice™ Stereotaxic Instrument was specifically developed for the expanding growth of research being conducted in laboratories using knock-out and transgenic mice. The Just For Mice™ is ideal for researchers in need of a versatile, reliable For Bone Drills, see pages 247 & 248 for Bone Rongeurs instrument for stereotaxic procedures with mice and other small and other Surgical Instruments, see pages 1-56. rodents. This innovative instrument allows the user to perform surgical procedures on two mice at one time. Precision alignment when using the Just For Mice™ ensures accurate placement of electrodes, micropipettes, cannula, and other devices. Just For Mice™ is the only instrument built especially for mice, and offers several advantages over competing “made for rat” instruments. The Just For Mice is available in manual, digital (see page 238), motorized (see page 239) and ultra-precise (see page 232) versions.

Saves Time Waiting time can be virtually eliminated. For example, in applications that require drying time for cranial plaster, surgery can be performed on one mouse while the cranial cement is NEUROSCIENCE drying on the other mouse. Or, one person can perform surgery while another person installs another mouse or neonatal rat.

Just for Mice is a trademark of Stoelting Co. Delrin is a registered trademark of E.I. du Pont de Nemours and Company.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 237 STEREOTAXIC INSTRUMENTS

Digital New Standard Digital Rotating Elliptical Stereotaxic Stereotaxic

Digital Stereotaxic Instruments Order # Model Product New Standard Stereotaxic • Saves time, improves accuracy ST1 72-6338 51500D Digital New Standard Stereotaxic for Rats and Mice • Zeroing function for targeting specific coordinates with Rat and Mouse Adapters, Dual Tip Rat and Delrin® Mouse Ear Bars • Easy-to-read digital display offers 10 µm ST1 72-6339 51503D Digital Dual New Standard Stereotaxic for Rats and resolution in all three axes Mice with Rat and Mouse Adapters, Dual Tip Rat and • Triple-lead screws for fast positioning Delrin® Mouse Ear Bars • 80 mm of dorsal-ventral, medial-lateral and Lab Standard Stereotaxic anterior-posterior travel ST1 72-6035 51900 Digital Lab Standard Stereotaxic for Rats with Rat Adaptor and 18° Ear Bars • Absolute lock at 90° vertical ST1 72-6036 51950 Digital Lab Standard Stereotaxic for Rats with Rat • Easily cleaned, durable surface Adaptor and 45° Ear Bars ST1 72-9570 51925 Digital Lab Standard Stereotaxic for Mice with Mouse The classic design and high quality of our conventional stereotaxic and Neonatal Rat Adaptor and Delrin® Ear Bars manipulators are exactly the same on the digital stereotaxic, with ST1 72-6344 51970 Digital Lab Standard for Rats and Mice with Rat no drift and smooth movements. The digital stereotaxic keeps and Mouse Adaptors, 18° and Delrin® Ear Bars the custom triple lead screws to allow fast positioning, while ST1 72-6037 51903 Digital Dual Lab Standard Stereotaxic for Rats maintaining consistently smooth movement. The thin cords from with Rat Adaptor and 18° Ear bars the sensors do not interfere with movements, allowing the arm to ST1 72-6038 51953 Digital Dual Lab Standard Stereotaxic for Rats move freely and be set at any angle. with Rat Adaptor and 45° Ear Bars ST1 72-9571 51928 Digital Dual Lab Standard Stereotaxic for Mice with The sealed electronic sensor is immune to interference and Mouse and Neonatal Rat Adaptor and Delrin® Ear Bars environmental conditions. Measurements are accurate to 10 µm in all directions and easily read on the large LED display. ST1 72-6345 51973 Digital Dual Lab Standard for Rats and Mice with Rat and Mouse Adaptors, 18° and Delrin® Ear Bars Memory Rotating Elliptical Stereotaxic ST1 72-6393 51900E Digital Rotating Elliptical Stereotaxic for Rats Target coordinates can be programmed into the memory of the ST1 75-0324 51925E Digital Rotating Elliptical Stereotaxic for Mice with digital stereotaxic. Mouse and Neonatal Rat Adaptor and Delrin® Ear Bars ST1 75-0326 51970E Digital Rotating Elliptical Stereotaxic for Rats and NEUROSCIENCE Zeroing Function for Targeting Specific Coordinates Mice with Rat and Mouse Adaptors, 18° and Delrin® Ear Bars A zeroing function makes setting a reference point for targeting ST1 72-6394 51903E Digital Dual Rotating Elliptical Stereotaxic for Rats specific coordinates on the animal’s skull as easy as 1-2-3. ST1 75-0325 51928E Digital Dual Rotating Elliptical Stereotaxic for Mice with Mouse and Neonatal Rat Adaptor 1. Find reference point, e.g. Bregma and Delrin® Ear Bars 2. Reset zero on LED display ST1 75-0327 51973E Digital Dual Rotating Elliptical Stereotaxic for Rats 3. Move manipulator arm to the desired coordinates and Mice with Rat and Mouse Adaptors, 18° and Delrin® Ear Bars Included Components Just for Mouse Stereotaxic Base, manipulator arm(s), LED digital display, standard probe holder(s) ST1 72-9563 51730D Digital Just for Mouse Stereotaxic with corner clamp, nose clamp assembly (adaptor) and ear bars. ST1 72-9566 51733D Digital Dual Just for Mouse Stereotaxic Just for Mice Stereotaxic ST1 72-6048 51725D Digital Just for Mice Stereotaxic

238 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com STEREOTAXIC INSTRUMENTS

StereoDrive Software is included with Motorized Stereotaxic Motorized Lab Standard Instruments. StereoDrive Software integrates seamlessly with the Stereotaxic precision controlled motors. Motor movement can be executed by using the keyboard arrow keys or clicking on the screen with the mouse. The software coordinates motor movement of all 3 axes (anterior- posterior, medial-lateral, and dorsal-ventral) probe placement in relation to 3-dimensional visual representation of a rat (Paxinos & Watson, 6th Edition) or mouse (Watson, 3rd edition) Brain Atlas.

Included Components • Base • Nose clamp assembly • Ear bars • Data acquisition control box • Motorized dovetail A-P drive • Motorized M-L and D-V drives Motorized Stereotaxic Instruments • Connection cables • USB cable • Digital atlas integration • StereoDrive Software, rat and mouse CD • Frame representation • Operating manual for StereoDrive Software • Calibration of frame coordinates • Setting of logical coordinate system (Bregma) • Rat Brain in Stereotaxic Coordinates, Compact 6th Edition • Coordinates and Atlas visualization of the probe • Mouse Brain in Stereotaxic Coordinates, • Advanced 3D visualization options Compact 3rd Edition • Spatial atlas representation • Power cord • Intuitive probe control

• Intuitive navigation Order # Model Product New Standard Stereotaxic The Motorized Stereotaxic Instrument combines the classic design ST1 72-6340 51500M Motorized New Standard Stereotaxic for of our stereotaxic frames with customized motors and state-of-the- Rats and Mice with Rat and Mouse Adapters, art software. Designed to adapt conventional stereotaxic systems, Dual Tip Rat and Delrin® Mouse Ear Bars the StereoDrive Software allows motorized, computer controlled Lab Standard™ Stereotaxic stereotaxic positioning in all 3 orthogonal axes. ST1 72-9552 51700 Motorized Lab Standard Stereotaxic for Rats with Rat Adaptor and 18° Ear Bars Integrated with Paxinos and Watson’s Rat Brain in Stereotaxic ST1 72-9553 51750 Motorized Lab Standard Stereotaxic for Rats Coordinates, for either rat or mouse, the intuitive movement control with Rat Adaptor and 45° Ear Bars enables unprecedented accuracy and higher throughput in all ST1 75-0328 51715 Motorized Lab Standard Stereotaxic for Mice stereotaxic applications. with Mouse and Neonatal Rat Adaptor and Delrin® Ear Bars Image manipulations include: ST1 75-0329 51770 Motorized Lab Standard Stereotaxic for Rats and Mice with Rat and Mouse Adaptors, 18° and Delrin® • Spatial Rotation Ear Bars 18° Ear Bars • Fixed Rotation Rotating Elliptical Stereotaxic ST1 72-6395 51700E Motorized Rotating Elliptical Stereotaxic for Rats • Zooming with Rat Adaptor and 18° Ear Bars ST1 75-0332 51715E Motorized Rotating Elliptical Stereotaxic for Mice • Panning with Mouse and Neonatal Rat Adaptor and Delrin® Ear Bars ST1 75-0333 51770E Motorized Rotating Elliptical Stereotaxic for Rats NEUROSCIENCE and Mice with Rat and Mouse Adaptors, 18° and Delrin® Ear Bars Just for Mouse Stereotaxic ST1 72-9567 51730M Motorized Just for Mouse Stereotaxic Just for Mice Stereotaxic ST1 72-9560 51725M Motorized Just for Mice Stereotaxic

Delrin is a registered trademark of E.I. du Pont de Nemours and Company.

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 239 STEREOTAXIC INSTRUMENTS

Digital Motorized Lab Standard New Standard Stereotaxic Stereotaxic

Digital Upgrade or Conversion Motorized Upgrade or Conversion

Upgrading or converting to digital will reduce the risk of human Upgrading or converting to motorized will provide you with error and increase accuracy (10 µm resolution instead of 100 µm automated movement in all 3 orthogonal axes. resolution). Your choice of two service options: Your choice of two service options: • Keep your existing arm. We will ship you a new • Keep your existing arm. We will ship you a new digital motorized manipulator arm and StereoDrive Software. manipulator arm and LED Display. • Send us your existing arm. We will convert your existing • Send us your existing arm. We will convert your existing manipulator arm to motorized and send you StereoDrive manipulator arm to digital for you. RMA required. Software. RMA required.

Order # Model Product Order # Model Product Option 1: New Digital Manipulator Arm and LED Display Option 1: New Motorized Manipulator Arm and StereoDrive Software ST1 72-6039 51904 LED Display and 3 Axis Manipulator Arm ADD-ON, ST1 72-9556 51704 StereoDrive Software and 3 Axis Manipulator Arm Left ADD-ON, Left ST1 72-6040 51906 LED Display and 3 Axis Manipulator Arm ADD-ON, Option 2: Conversion to Motorized Manipulator Arm Right and StereoDrive Software Option 2: Digital Conversion of Existing Manipulator Arms ST1 72-9558 51714 Factory CONVERSION to Motorized 3 Axis ST1 72-6041 51914 Factory CONVERSION to Digital Plus LED Display Manipulator Arm ADD-ON, Left and 3 Axis Manipulator Arm, Left ST1 72-6042 51916 Factory CONVERSION to Digital Plus LED Display and 3 Axis Manipulator Arm, Right

Ultra-Precise Upgrade NEUROSCIENCE Upgrading to ultra-precise increases precision (from 100 µm to 10 µm resolution) and allows you to confidently target small regions of the brain. Ideal for mice and neonatal animals.

Order # Model Product ST1 72-6168 51604U Ultra-Precise 3-Axis Manipulator Arm ADD-ON, Left ST1 72-6169 51606U Ultra-Precise 3-Axis Manipulator Arm ADD-ON, Right

240 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com STEREOTAXIC INSTRUMENTS

Included Components: The ST1 72-4798 Parallel Rail Stereotaxic for Cat/Monkey comes equipped with: • Two ST1 72-4804 LH Manipulators • Two ST1 72-4805 RH Manipulators • One ST1 72-4799 Parallel Rail Frame • One ST1 72-4824 Cat/Monkey Head Holder with 20° Ear Bars • One ST1 72-4797 Universal Swivel Stand with 102 x 102 mm (4 x 4 in) Mounting Support Stand • One ST1 72-4802 Base Plate, Plain 330 x 432 mm (17 x 13 in) • Four ST1 72-4829 Standard Probe Holder with Corner Clamp The ST1 72-4799 Parallel Rail Frame Assembly Only for Cat/Monkey comes equipped with: • One ST1 72-4799 Parallel Rail Frame • One ST1 72-4824 Cat/Monkey Head Holder with 20° Ear Bars • One ST1 72-4797 Universal Swivel Stand with 102 x 102 mm (4 x 4 in) Mounting Support Stand • One ST1 72-4802 Base Plate, Plain 330 x 432 mm (17 x 13 in) The ST1 72-4800 Large Parallel Rail Stereotaxic for Dog comes equipped with: • Two ST1 72-4804 LH Manipulators • Two ST1 72-4805 RH Manipulators • One ST1 72-4801 Large Parallel Rail Frame • One ST1 72-4826 Highly Adjustable Dog/Monkey Head Large Animal Stereotaxic Instruments Holder with 20° Ear Bars • One ST1 72-4797 Universal Swivel Stand with 102 x 102 mm • For use with rats, cats, monkeys and dogs (4 x 4 in) Mounting Support Stand • One ST1 72-4802 Base Plate, Plain 330 x 432 mm (17 x 13 in) • Laser engraved scales • Four ST1 72-4829 Standard Probe Holder with Corner Clamp • Exceptionally accurate The ST1 72-4801 Large Parallel Rail Frame Assembly Only for Dog • Versatile comes equipped with: • Holds up to six manipulator arms • One ST1 72-4801 Large Parallel Rail Frame The Parallel Rail Animal Stereotaxic Instrument provides superior • One ST1 72-4826 Highly Adjustable Dog/Monkey Head performance. Up to six (ST1 72-4798) or eight (ST1 72-4800) • One ST1 72-4797 Universal Swivel Stand with 102 x 102 mm manipulator arms may be conveniently positioned on the two (4 x 4 in) Mounting Support Stand parallel rails. Thus, several probes may be independently positioned • One ST1 72-4802 Base Plate, Plain 330 x 432 mm (17 x 13 in) in one animal. Optional Mounting Plates Easily Read Scales The optional ST1 72-4803, mounting plate 305 x 914 mm Precise, laser engraved graduations allow vernier scales to be (12 x 36 in) base plate has four, full-length tee slots for mounting aligned to 0.1 mm. The scales are oriented to enhance readability other instruments on the same base with a ST1 72-4798 or ST1 72-4800 stereotaxic. from common user positions. Standard manipulator arms have 100 µm resolution, while high-quality digital arms have a resolution of Order # Model Product 10 µm. ST1 72-4798 51800 Parallel Rail Stereotaxic for Cat/Monkey, Complete with 4 Manipulators Versatile ST1 72-4799 51801 Parallel Rail Frame Assembly Only, Cat/Monkey Other species adaptors, probe holders and ear bars may be used ST1 72-4800 51850 Large Parallel Rail Stereotaxic for Dog, Complete allowing the stereotaxic instrument to be used with a wide range of with 4 Manipulators animals and procedures. ST1 72-4801 51851 Large Parallel Rail Frame Assembly Only, Dog NEUROSCIENCE ST1 72-4802 51871 Base Plate, 330 x 432 mm (13 x 17 in) A/P Microdrive Available ST1 72-4803 51872 Base Plate, Slotted, 305 x 914 mm (12 x 36 in) ST1 72-4804 51804 Manipulator, LH The optional ST1 72-4806 Anterior/Posterior Microdrive provides ST1 72-4805 51806 Manipulator, RH fine movement control in the A/P dimension with 25 mm range and ST1 72-4806 51858 A/P Microdrive 10 µm graduations. The A/P Microdrive mounts between the rail and 51680 Universal Mounting Support Stand the manipulator and it includes a longer probe holder shaft for the ST1 72-4797 extra height. ST1 72-4864 51902 LED Display +Two Axis Manipulator, ADD-ON, RH ST1 72-4865 51905 LED Display +Two Axis Manipulator, ADD-ON, LH

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 241 STEREOTAXIC ACCESSORIES

Mouse and Neonatal Rat Adaptor for Stereotaxic Instruments (frame not included)

Mouse Adaptor

Mouse Adaptor

Ear bars can cause breathing difficulties and bleeding in mice. The Mouse Adaptor holds the mouse head by means of a palate bar and nose clamp, without ear bars. Head angle may be adjusted to achieve flat skull or other approach angles. Since there are no earbars, the Mouse Adaptor fits 51600, 51800 and 51900 Series Mouse and Neonatal Rat Adaptor stereotaxic instruments.

• Independent height adjustment of ear bars If you want to use ear bars to perform stereotaxic surgery on mice, to level the skull we offer the perfect miniature stereotaxic stage surgery: The Mouse and Neonatal Rat Adaptor, pictured to the left. • Delrin® ear bars; tapered points on one end and rubber pads on the other • Triple point securing of the animals head Order # Model Product ST1 72-4819 51624 Mouse Adaptor for 51600, 51800 and 51900 Series • Laser engraved scales show vertical position of ear bars Stereotaxic Frames • Clamps securely to stereotaxic frame

Model organisms with soft skulls, such as the mouse and the Rat Adaptor neonatal rat, have traditionally been difficult to secure firmly in a stereotaxic instrument. The stainless steel ear bars used for adult rats are too heavy to position precisely enough to provide a secure hold while still avoiding flexing the sides of the skull inward (which compresses the airways and impedes blood flow). Further, the neonatal rat pup has no external opening of the auditory canal into which to insert the ear bar points.

The Mouse and Neonatal Rat Adaptor The Mouse and Neonatal Rat Adaptor employs light, Delrin® ear bars with tapered points on one end, and rubber pads on the other, to facilitate surgery on such animals. Neonatal surgery may be accomplished with minimally invasive procedure by using the rubber pad ends of the ear bars. Ear bars may be independently adjusted in height, a unique feature to this stereotaxic instrument, Rat Adaptor to level the skull. Laser engraved scales shows the vertical position

NEUROSCIENCE of the ear bars. A tooth bar and nose clamp secures the nose. The Rat Adaptor includes the nose clamp assembly and ear bars. It is an optional extra for the ST1 72-4798 and ST1 72-4800 Large A set of two specialized Jaw Holder Cuffs (ST1 72-4795), which Animal Stereotaxic Instruments. securely clamp the zygomatic processes of the skull, are included with this adaptor. The jaw holder cuffs fit over the ends of the ear bars, replacing the rubber pads, providing an alternative non-invasive Order # Model Product means of securing the animal’s head in the stereotaxic stage. These ST1 72-4815 51621 Rat Adaptor with 18° Ear Bars for 51600 and 51900 options for “triple point” securing of the animal’s head in this adaptor Series Stereotaxic Frames make it the most versatile mouse stereotaxic available. ST1 72-4816 51620 Rat Adaptor with 45° Ear Bars (Non-Puncture) for 51600 and 51900 Series Stereotaxic Frames ST1 72-4817 51821 Rat Adaptor with 18° Ear Bars for 51800 Series Order # Model Product Stereotaxic Frame ST1 72-4794 51625 Mouse and Neonatal Rat Adaptor ST1 72-4818 51820 Rat Adaptor with 45° Ear Bars (Non-Puncture) for ST1 72-4795 51647 Replacement Jaw Holder Cuffs, Set of 2 51800 Series Stereotaxic Frame ST1 72-6170 51648 Replacement Ear Bars, Set of 2 ST1 75-0334 51629 Replacement Snout Clamp Delrin is a registered trademark of E.I. du Pont de Nemours and Company.

242 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com STEREOTAXIC ACCESSORIES

Guinea Pig Adaptor

Guinea Pig Adaptor The Guinea Pig Adaptor includes the nose clamp assembly and 45° ear bars required for guinea pigs. The nose clamp reaches further back behind the incisors than on the rat adaptors. The Guinea Pig Adaptor is available for the 51600, 51800 and 51900 series stereotaxic instruments.

Order # Model Product ST1 72-4820 51622 Guinea Pig Adaptor with 45° Ear Bars for 51600 and 51900 Series Stereotaxic Frame ST1 72-4821 51822 Guinea Pig Adaptor with 45° Ear Bars for 51800 and 51900 Series Stereotaxic Frame

Dog/Monkey Adaptor Cat/Monkey Adaptor

Dog/Monkey Adaptor Cat/Monkey Adaptor

The Dog/Monkey Adaptor is available only for the 51800 Series The Cat/Monkey Adaptor for the 51600 Series includes spacers and stereotaxic instruments. It should be used with the ST1 72-4800 bolts to raise the ‘U’ frame 64 mm (2.5 in) above the base plate, as or ST1 72-4801 Parallel Rail Stereotaxic Frames which have two well as the eye socket/palate holder and 20° ear bars used for cats sets of ear bar holders at different spacings from the front to and monkeys. accommodate a wide size range of dogs. The Cat/Monkey Adaptor is available for the 51600 and 51800 Series Stereotaxic instruments. Order # Model Product ST1 72-4826 51852 Dog/Monkey Adaptor with 20° Ear Bars for 51800 Order # Model Product Series Stereotaxic Frame ST1 72-4822 51626 Cat/Monkey Adaptor with 20° Ear Bars for 51600 Series Stereotaxic Frame ST1 72-4823 51627 Cat/Monkey Adaptor with 45° Ear Bars for 51600 Series Stereotaxic Frame ST1 72-4824 51826 Cat/Monkey Adaptor with 20° Ear Bars for 51800 Series Stereotaxic Frame ST1 72-4825 51827 Cat/Monkey Adaptor with 45° Ear Bars for 51800 Series Stereotaxic Frame NEUROSCIENCE

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 243 STEREOTAXIC ACCESSORIES

Small Bird Adaptor Small Bird Adaptor

The Small Bird Adaptors include the nose clamp assembly and 45° ear bars required for birds. The Small Bird Adaptor uses a beak support and “V” shaped beak clamp to hold the beak down and centered. This is in place of the incisor bar/nose clamp arrangement used for rats.

Order # Model Product ST1 72-4827 51623 Small Bird Adaptor with 45° Ear Bars for 51600 Series Stereotaxic Frame ST1 72-4828 51823 Small Bird Adaptor with 45° Ear Bars for 51800 Series Stereotaxic Frame

Lab Standard™ Ear Bars

• For rats in a stereotaxic instrument

Spinal Adaptor Lab Standard Ear Bars have laser engraved scales. These ear bars are 6.2 mm square. Ear bars for the 51600 series of stereotaxic • Models to hold mice or rats for stereotaxic spinal surgery instruments have a different zero point than do those for the 51800 series. The design of this instrument was inspired by the need for a practical, versatile, and economical instrument for reliably Standard ear bars have an 18° taper at the tip to penetrate far into stabilizing the rodent spinal column. The Spinal Adaptor is an the ear canal for a more secure hold. They puncture the tympanic accessory to be mounted on either the 51600 or the 51800 Series membrane. Non-puncture ear bars have a 45° taper, and do not stereotaxic instruments or other brands of stereotaxic instruments, puncture the tympanic membrane, but offer a slightly less converting them for spinal surgery applications. It utilizes the stable hold. manipulator and base plate of the stereotaxic instrument, thus enabling precision spinal preparations. The spinal column is secured Order # Model Product by up to four independent transverse process clamps, as well as a ST1 72-4838 51611 Ear Bars, Rat, 18° for 51600 Series spinous process clamp. The transverse process clamps are designed Stereotaxic Frame to minimize trauma while providing motionless support. ST1 72-4839 51612 Ear Bars, Rat, 45° Non-Puncture for 51600 Series Stereotaxic Frame

NEUROSCIENCE The instrument is engineered for one-handed control of gross and 51811 Ear Bars, Rat, 18° for 51800 Series fine adjustment of the surgical preparation in the AP, ML, and DV ST1 72-4840 Stereotaxic Frame planes. ST1 72-4841 51812 Ear Bars, Rat, 45° Non-Puncture for 51800 Series Transverse process clamps are available to accommodate either Stereotaxic Frame the rat or the mouse. To work with both species, order the Spinal ST1 72-4842 51613 Ear Bars, Cat, 20° for 51600 Series Adaptor for one species, and one set of transverse clamps for Stereotaxic Frame the other. ST1 72-4843 51614 Ear Bars, Cat, 45° Non-Puncture for 51600 Series Stereotaxic Frame ST1 72-4844 51813 Ear Bars, Cat, 20° for 51800 Series Order # Model Product Stereotaxic Frame ST1 72-4811 51690 Mouse Spinal Adaptor ST1 72-4845 51814 Ear Bars, Cat, 45° Non-Puncture for 51800 Series ST1 72-4812 51695 Rat Spinal Adaptor Stereotaxic Frame ST1 72-4813 51691 Mouse Transverse Clamps, Set of Four ST1 72-4814 51692 Rat Transverse Clamps, Set of Four Lab Standard is a trademark of Stoelting Co.

244 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com STEREOTAXIC ACCESSORIES

StereoDraft

The StereoDraft is a heating and scavenging system designed to fit on a stereotaxic frame. It is a precisely machined apparatus which maintains the surgical plane. The StereoDraft brings fresh gas to the nose cone while the waste gas is evacuated via vacuum source allowing the animal to be anesthetized while maintaining a safe environment for the researcher. This platform will also keep the animal warm while in the stereotaxic frame. Two side ports include tubing with clik-tite® connectors for easy connection to either a Heat Therapy Pump, see page 70 or a Thermocirculator, please call.

Order # Product ST1 75-0349 StereoDraft

This Gas Anesthesia Platform and Mask for mice provides precise and secure positioning of an animal during anesthesia and surgery. The platform provides positioning of the animal that is perfect, Gas Anesthesia automatic and effortless. After removing the animal from the Platform for Mice induction chamber, it can be quickly mounted on the platform. The animal’s teeth are placed over the incisor bar and the mouse mask slides forward until the cone is snug around the animal’s nose, thereby substituting for the nose clamp. The gas anesthesia platform and mask is also useful for non-stereotaxic related experimental applications. With the platform placed on your bench top, simply fix the head of the mouse or rat in the mask, attach 1 appropriate tubing ( ⁄4 inch ID) to the gas mask, and you’re ready to perform surgery, injections, or implantations under gas anesthesia. ST1 72-6044 Gas Anesthesia Platform Plus Mouse Gas Mask Adaptor can be used with Just for Mouse and Just for Mice Stereotaxic Instruments as well as the Mouse and Neonatal Rat Adaptor. Gas Anesthesia Platform for Mice Order # Model Product • Holds mice during anesthesia and surgery ST1 72-6044 50264 Gas Anesthesia Platform plus Mouse Gas Mask Adaptor • Precise and secure positioning ST1 72-6171 50264MR MRI Compatible Gas Anesthesia Platform plus • MRI compatible option Mouse Gas Mask Adaptor

opening toward the open ‘U’. The animal’s teeth are placed over Gas Anesthesia Mask shown the incisor bar and the adaptor is slid forward until the cone is snug with 51621 Rat Adaptor about the animal’s nose. The mask substitutes for the nose clamp. (not included) The teeth and the cone provide a very stable hold. Gas flows in the tubing connector on one side, past the animal’s nose, and out the tubing connector on the other side. From there, spent gas may be routed to recycling, exhaust, or gas analysis instruments. The ST1 72-4852 Gas Anesthesia Mask Adaptor for mice can only be used with the New Standard Stereotaxic Equipment. When working with mice, all other Stereotaxic Instruments require the use of Gas Anesthesia Platform plus Mouse Gas Mask Adaptor. Gas Anesthesia Mask Adaptors NEUROSCIENCE ST1 72-4853 Gas Anesthesia Mask Adaptor for Rats can be used • For rats and mice in a stereotaxic instrument with the Lab Standard, the New Standard and the Elliptical Stereotaxic Instruments. The Gas Anesthesia Mask Adaptors enable gas anesthesia of rats and mice in a stereotaxic instrument, without exposing the researcher to the anesthetic gas. The Gas Anesthesia Mask Adaptor Order # Model Product is installed by removing the nose clamp from the standard rat or ST1 72-4853 51610 Gas Anesthesia Mask Adaptor, Rats mouse adaptor, sliding the mask over the incisor bar, with the cone ST1 72-4852 51609 Gas Anesthesia Mask Adaptor, Mice

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 245 STEREOTAXIC ACCESSORIES

Standard Probe Extra Large Probe Holder Holders

Standard Probe Holder Extra Large Probe Holder

Standard Probe Holders come complete with mounting “V” blocks. • Holds Micro Drill hand piece The 11 mm square acrylic block on the bottom has grooves spaced 1 mm apart. Three bottom clamp options are available. The corner Extra Large Probe Holders support shafts with diameters from clamp holds shafts from 0.2 to 2.0 mm. The side clamp holds 13 mm up to 26 mm. This will hold the hand piece of the probes from 0.2 to 4.5 mm, as does the “C” clamp, which is useful ST1 72-4950 and ST1 72-4951 Bone Micro Drill, allowing you to to release implanted probes. The ST1 72-4829 Standard Probe attach the Micro Drill to a Stereotaxic Instrument. See page 247. Holder with Corner Clamp is included with each manipulator on complete instruments. Order # Model Product ST1 72-4860 51630 Extra Large Probe Holder Order # Model Product ST1 72-4829 51631 Holder with Corner Clamp ST1 72-4830 51632 Holder with Side Clamp Cannula Holder ST1 72-4831 51634 Holder with “C” Clamp

Large Probe Holder Large Probe Holder • Holds glass syringes Large Probe Holders support shafts with diameters from 6.5 mm up to 13 mm (0.5 in). This will hold Hamilton™ microsyringes, and any accessories designed for Stereotaxic Instruments. A threaded drive pulls the Cannula Holder sliding ‘U’ holder against the outside of the probe, pulling the probe into a “V” notch for straight and reproducible positioning. Holds standard 3.4 mm diameter cannula heads, as manufactured by Plastics One™, Order # Model Product for cannula sets, and Alzet® ST1 72-4832 51633 Large Probe Holder for minipumps. Tapered non- intrusive for easily cementing Microdialysis Holder cannulae in place. Microdialysis Holder NEUROSCIENCE The Microdialysis Probe Holder is designed to fit a specific size of probe. The hole in the stainless steel foot may be drilled to fit probes from 1.5 to 6.0 mm. Our standard sizes are 1.5 and 2.0 mm holes. Other sizes are available by special order. Order # Model Product ST1 72-4837 51636 Cannula Holder Order # Model Product ST1 72-4835 51637 Microdialysis Holder with 1.5 mm Hole Hamilton is a trademark of Hamilton Co. ST1 72-4836 51637-2.0 Microdialysis Holder with 2.0 mm Hole Plastics One is a trademark of Plastics One Inc. Alzet is a registered trademark of Durect Corp.

246 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com STEREOTAXIC ACCESSORIES

Bone Micro Drll System Order # Product ST1 72-4950 Complete Bone Micro Drill System, 120 VAC* ST1 72-4951 Complete Bone Micro Drill System, 230 VAC* ST1 72-4967 Accessory Kit for Micro Drill ST1 72-4952 Abrading Tip, Rubber, pkg. of 20 ST1 72-4953 Abrading Tip, Stone, pkg. of 5 ST1 72-4954 Accessory Stand ST1 72-4955 Ball Mill, Carbide, #1, .031 in Diameter, pkg. of 5 ST1 72-4956 Ball Mill, Carbide, #2, .039 in Diameter, pkg. of 5 ST1 72-4957 Ball Mill, Carbide, #3, .047 in Diameter, pkg. of 5 ST1 72-4958 Ball Mill, Carbide, #4, .055 in Diameter, pkg. of 5 ST1 72-4959 Ball Mill, Carbide, #5, .063 in Diameter, pkg. of 5 ST1 72-4960 Ball Mill, Carbide, #6, .071 in Diameter, pkg. of 5 ST1 72-4961 Ball Mill, Carbide, #7, .083 in Diameter, pkg. of 5

1 ST1 72-4962 Ball Mill, Carbide, # ⁄4, .019 in Diameter, pkg. of 5

1 ST1 72-4963 Ball Mill, Carbide, # ⁄2, .027 in Diameter, pkg. of 5 Bone Micro Drill System For Brain Surgery ST1 72-4964 Cutoff Disk, pkg. of 20 • Dental quality construction for delicate work ST1 72-4965 Mandrel, Screw, pkg. of 5 ST1 72-4966 Mandrel, Threaded, pkg. of 5 • Flexible telephone-style cord eliminates bothersome drive cables *Note: Includes Accessory Kit. • Quick change chuck for easy bit replacement Accessory Kit for Bone Micro Drill System • Versatile forward, reverse, and variable speeds Order # Product • Small, lightweight, ergonomically designed hand ST1 72-4967 Accessory Kit for Bone Micro Drill System piece reduces fatigue Kit Components: • Complete - includes ball mills, abrasive bits, and - Abrading Tip, Rubber, pkg. of 4 cutting discs - Abrading Tip, Stone, pkg. of 1 - Accessory Stand, pkg. of 1 This Micro Drill is a workhorse in a kit. This versatile powerhouse is - Ball Mill, Carbide, #1, .031 in Diameter, pkg. of 1 - Ball Mill, Carbide, #2, .039 in Diameter, pkg. of 1 ideal for milling, drilling, grinding and cutting. This drill quickly cuts - Ball Mill, Carbide, #3, .047 in Diameter, pkg. of 1 through bone and other materials. It may also be used for general - Ball Mill, Carbide, #4, .055 in Diameter, pkg. of 1 purpose work such as removing coatings, cutting, drilling holes, - Ball Mill, Carbide, #5, .063 in Diameter, pkg. of 1 cutting slots, as well as performing many other procedures using - Ball Mill, Carbide, #6, .071 in Diameter, pkg. of 1 various interchangeable bits. Unlike most hand-held tools, the Micro - Ball Mill, Carbide, #7, .083 in Diameter, pkg. of 1 1 - Ball Mill, Carbide, # ⁄4, .019 in Diameter, pkg. of 1 Drill has a tiny, high speed DC motor in the hand piece, eliminating 1 - Ball Mill, Carbide, # ⁄2, .027 in Diameter, pkg. of 1 bothersome drive cables and giving the researcher better control. - Cutoff Disk, pkg. of 4 A separate power supply keeps the hand piece lightweight and - Mandrel, Screw, pkg. of 1 reduces fatigue. Power is supplied by a panel switch or foot switch - Mandrel, Threaded, pkg. of 1 for ease of use. The Ball Mills are dental grade carbide steel for precision cutting and long life. All sizes have a 0.093 in diameter shank. The complete Micro Drill System is supplied with a variety of Ball Mills, but you may also purchase them separately. This Micro Drill System is supplied complete with hand piece, cord, power supply, hand piece stand and ST1 72-4967 Accessory Kit. The contents of the Accessory Kit are listed in the chart to the right. Additional Ball Mills and accessories are also available separately in the quantities noted in the ordering information. With the addition of ST1 72-4860 Extra Large Probe Holder, you can attach the Micro Drill to a Stereotaxic Instrument, see page 232-237. NEUROSCIENCE

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 247 STEREOTAXIC ACCESSORIES

Ideal Micro-Drill

Ideal Micro-Drill™ Specifications Length 17.5 cm (without burr) • Rechargeable Diameter 1.9 cm • Light-weight design Power 6 V DC • No special tools needed to charge burrs Speed 12,000 rpm • Excellent balance and handling Stall Torque 1.25 oz/in • Appropriate for Mice Order # Product The Ideal Micro-Drill™ is designed for research applications that ST1 72-6065 Ideal Micro-Drill™ Complete Kit require surgical burrs and trephines. The drill is constructed of light- ST1 72-6066 Ideal Burr Set of 5 each weight aluminum alloy for balance and control and is powered by a rechargeable 6-volt nickel cadmium battery (charger included). *Note: Charger is 120 VAC, 60 Hz. Under normal operating conditions the unit will function for 8 hours between recharging.

Artificial CSF Perfusion Fluid NEUROSCIENCE

Artificial CSF Perfusion Fluid Application Note: Perfusion Fluid

Artificial cerebrospinal fluid (aCSF) is commonly used when The perfusion fluid should be identical in composition to the sampling from brain interstitial fluid. This solution closely matches interstitial fluid being sampled except that it is devoid of the the electrolyte concentrations of CSF. It is prepared from high purity substances of interest (or has excess concentration of the substance water and analytical grade reagents. It is microfiltered and sterile. to be delivered). Perfusion fluids vary widely in terms of their Final Ion Concentrations (in mM): Na 150; K 3.0; Ca 1.4; Mg 0.8; P 1.0; composition and pH. Generally, they are prepared as iso-osmatic Cl 155. Supplied as a package of six 25 ml vials. as possible.

Order # Product ST1 59-7316 Artificial CSF Perfusion Fluid

248 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com MATRICES

Rat Acrylic Rodent Brain Matrices • Repeatable slices from 0.50 to 3.00 mm • Coronal or sagittal sectioning • Available in acrylic or stainless steel - (other materials upon request) • Custom sizes and shapes • Slices can be made with razor blades (included)

These Rodent Brain Matrices aid in the dissection of discrete regions of a rodent brain or comparably sized organ. They allow the investigator to slice repeatable coronal or sagittal sections of the sample, enabling precise blocking prior to microtome sectioning and the removal of small, reproducible brain regions (i.e. discrete terminal ST1 72-5023 ST1 72-5018 1 mm Sagittal 2 mm Coronal fields or nuclei) for biochemical analysis, such as the determination of neurotransmitter and metabolite concentrations. Individual brain areas may be stained, dissected or micropunched (using micron Mouse Acrylic biopsy punches, see page 250) from the slices formed. All matrices are designed for long-term use, and matrices of any given type are identical to insure reproducible sections. Channels are cut at precise intervals ranging from 0.50 mm to 3.00 mm and are 0.3 mm wide. Other species, sizes, and materials are available upon request. Please contact technical support for more information.

Coronal Sagittal Order# Order# Animal Slice Width Stainless Steel Brain Matrices ST1 72-5051 ST1 72-5053 Neonatal Mouse 0.5 mm ST1 72-5052 ST1 72-5054 Neonatal Mouse 1 mm ST1 72-6225 ST1 72-6229 Neonatal Rat 0.5 mm ST1 62-0050 ST1 72-5027 1 mm Coronal 2 mm Sagittal ST1 72-6226 ST1 72-6230 Neonatal Rat 1 mm ST1 72-6227 ST1 72-6231 Neonatal Rat 2 mm ST1 72-6228 ST1 72-6232 Neonatal Rat 3 mm Rat & Mouse ST1 72-6235 ST1 72-6236 Mouse 0.5 mm Stainless Steel ST1 72-5032 ST1 72-5038 Mouse 1 mm ST1 72-5033 ST1 72-5039 Mouse 2 mm ST1 72-5034 ST1 72-5040 Mouse 3 mm ST1 72-5055 ST1 72-5057 Rat Pup 15-35 g 0.5 mm ST1 72-5056 ST1 72-5058 Rat Pup 15-35 g 1 mm ST1 72-5059 ST1 72-5061 Young Rat 35-175 g 0.5 mm ST1 72-5060 ST1 72-5062 Young Rat 35-175 g 1 mm ST1 72-6233 ST1 72-6234 Adult Rat 175-350 g 0.5 mm ST1 72-5029 ST1 72-5035 Adult Rat 175-350 g 1 mm ST1 72-5030 ST1 72-5036 Adult Rat 175-350 g 2 mm ST1 72-5031 ST1 72-5037 Adult Rat 175-350 g 3 mm ST1 72-5042 ST1 72-5047 Large Rat 350-650 g 0.5 mm ST1 72-5045 ST1 72-5048 Large Rat 350-650 g 1 mm ST1 72-5029 ST1 72-5032 ST1 72-6250 ST1 72-5049 Large Rat 350-650 g 2 mm 1 mm Coronal Rat 1 mm Coronal Mouse ST1 72-5046 ST1 72-5050 Large Rat 350-650 g 3 mm Acrylic Brain Matrices ST1 72-6216 ST1 72-5063 Neonatal Rat 1 mm

ST1 72-6217 ST1 72-5064 Neonatal Rat 2 mm NEUROSCIENCE ST1 72-6218 ST1 72-5065 Neonatal Rat 3 mm ST1 62-0050 ST1 72-5026 Mouse 1 mm ST1 62-0051 ST1 72-5027 Mouse 2 mm ST1 72-5022 ST1 72-5028 Mouse 3 mm ST1 62-0047 ST1 72-5023 Adult Rat 175-350 g 1 mm ST1 62-0048 ST1 72-5024 Adult Rat 175-350 g 2 mm ST1 62-0049 ST1 72-5025 Adult Rat 175-350 g 3 mm

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 249 MATRICES AND BIOPSY PUNCHES

Coronal Sagittal Mouse Heart Matrix Rat Heart Matrix Order # Order# Animal Slice Width Rat Spinal Cord Matrix Stainless Steel Heart Matrices ST1 72-6248 ST1 72-6249 Mouse 0.5 mm ST1 72-6243 ST1 72-6251 Mouse 1.0 mm ST1 72-9466 ST1 72-6252 Mouse 2.0 mm ST1 72-6253 ST1 72-6256 Rat 0.5 mm ST1 72-6244 ST1 72-6257 Rat 1.0 mm ST1 72-6254 ST1 72-6258 Rat 2.0 mm ST1 72-6255 ST1 72-6259 Rat 3.0 mm Acrylic Heart Matrices Rodent Heart, Spinal Cord & Tumor Matrices ST1 72-6210 ST1 72-6260 Mouse 1.0 mm ST1 72-6211 ST1 72-6261 Mouse 2.0 mm • Repeatable slices from 0.50 to 3.00 mm ST1 72-6212 - Mouse 3.0 mm • Mouse and rat ST1 72-5014 ST1 72-6247 Rat 1.0 mm ST1 72-5015 ST1 72-6262 Rat 2.0 mm • Custom sizes and shapes available upon request ST1 72-5016 ST1 72-6263 Rat 3.0 mm These Rodent Heart and Spinal Cord Matrices aid in the dissection Acrylic Spinal Cord Matrices of discrete regions of a rodent heart or spinal cord, or comparably ST1 72-6213 - Rat 1.0 mm sized organ. They allow the investigator to slice repeatable sections ST1 72-6214 - Rat 2.0 mm of the sample, enabling precise blocking prior to microtome ST1 72-6215 - Rat 3.0 mm sectioning and the removal of small, reproducible brain regions (i.e. discrete terminal fields or nuclei) for biochemical analysis. All matrices are designed for long-term use, and matrices of any given type are identical to ensure reproducible sections. Channels are cut at precise intervals ranging from 0.50 to 3.00 mm and are 0.3 mm wide. Other species, sizes and materials are available upon request.

Micron Biopsy Punches These Micron Punches are ideal for dissection or removal (“punch”) of discrete brain regions. Enabling the removal of specific brain nuclei, tracts and other subdivisions, Micron Biopsy Punch applications include dissection for analysis of neurotransmitter concentrations of mRNA levels, preparation of regions prior to acute dissociation for patch recording, and tissue preparation for pharmacological analysis of neurotransmitters and metabolite changes in response to different pharmacological agents. The Micron Punch has a stainless steel tip, brass handle, and punch diameters ranging from 0.30 mm to 5.0 mm.

Order # Product ST1 72-6246 5000 Micron Punch, 5.0 mm ST1 72-6245 3000 Micron Punch, 3.0 mm ST1 72-5041 2000 Micron Punch, 2.0 mm NEUROSCIENCE Micron Biopsy Punches ST1 62-0052 1000 Micron Punch, 1.0 mm 750 Micron Punch, 0.75 mm • Stainless steel tips ST1 62-0053 ST1 62-0054 500 Micron Punch, 0.50 mm • Circular sectioning diameters from 0.30 mm ST1 62-0055 300 Micron Punch, 0.30 mm • Expulsion tube and syringe provided • Can be used with sections from brain slicers and tissue matrices

250 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com NANOMITE SYRINGE PUMP

Pump 11 Elite Nanomite Specifications Type Microprocessor single syringe, infusion/withdrawal Features Accuracy ±0.5% • 11 pounds of pumping force Reproducibility ±0.1% Syringe: • Remote pump head Type Glass • Legendary reliability - 2 year warranty Size Minimum 0.5 µl Size Maximum 1 ml Applications Flow Rate: • Stereotaxic devices Minimum 3.66 pl/min • Space limited Maximum 3.82 ml/min Voltage Range Universal input 100/240 VAC, 50/60 Hz, 18 watts The Nanomite is an exceptionally small syringe pump ideal for space (Power Supply) (Use only a Harvard Apparatus approved supply limited applications and mounting onto stereotaxic frames. The and line cord) Nanomite consists of a control unit, an injection unit, a 6 foot cable Dimensions, H x W x D: to connect the two units, and a footswitch. Control Unit 22.6 x 17.78 x 9.32 cm (9 x 7 x 3.6 in) Injector Unit 6.35 x 5.08 x 19.05 cm (2.5 x 2.06 x 7.5 in)

Order # Product ST1 70-4507 Pump 11 Elite Nanomite NEUROSCIENCE

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 251 NEUROSCIENCE SPOTLIGHT

Harvard Apparatus Spotlight On: Brain Injury a role for EPO

Erthropoietin crosses the blood-brain barrier capillary areas and localized to neurons. Brines et. al. found that in all to protect against experimental brain injury test cases there was a significant neuroprotective effect of systemic IP injection of r-Hu-EPO. Systemic injection of r-Hu-EPO delivered Equipment Featured: 3 hr after reversible carotid artery occlusion showed a significant ST1 72-5029 Coronal Brain Matrix, 1 mm, Rat page 249 reduction of necrosis volume as compared to control animals (in paper Figure 3). Animals receiving a non-penetrating blunt force ST1 72-9715 Heat Therapy Pump and Pad, page 70 blow to the cortex also showed significant reductions in necrosis as ST1 60-1956 Single Probe Thermometer and 52-1583 Rectal compared to control animals as shown by cresyl violet staining (in Thermocouple for Rats, pages 74 & 78 paper Figure 4) when test animals received a systemic IP injection of r-Hu-EPO 24hrs prior to receiving a head injury. Finally test subjects ST1 72-4791 Lab Standard Stereotax, page 234 had markedly less severe seizures and increased latency to seizure as Summary: compared to control animals when treated with systemic r-Hu-EPO Erythropoietin (EPO) and its receptor (EPO-R) are known mediators (in paper Figures 5 & 6). Overall r-Hu-EPO has shown to be a safe of the body’s response to hypoxia. EPO is produced and widely therapeutic agent. The present study shows the potential for using it expressed throughout the body including in the central nervous in as a safe therapeutic agent and suggests further development of system. Brines et. al. (2000) hypothesized that since studies have r-Hu-EPO into therapies for head trauma. shown EPO is present in the central nervous system there may be Suggested Additional Equipment: a mechanism of transport across the blood brain barrier (BBB). ST1 70-4504 Pump 11 Elite Nanomite, page 251 Brines et. al. (2000) also hypothesized that systemic injections of recombinant human EPO (r-Hu-EPO) can ameliorate the effects ST1 72-6467 Complete Animal Isoflurane System, page 158 of traumatic brain injury caused by general injury such as strokes Sutures, page 39 caused by occluding the carotid artery, seizures induced by kainite, and injury through blunt force. R-Hu-EPO is found to be present beyond the BBB. Immunohistochemical staining with streptavidin- Brines, M.L. et. al. (2000) PNAS, Vol. 97:10526-10531. peroxidase revealed that at 5 hrs post-systemic IP injection of a biotinylated r-Hu-EPO, there was significant extension of r-Hu-EPO beyond the capillary beds into the perenchyma therefore showing r-Hu-EPO crossed the BBB. At 17 hrs post systemic IP injection of Scan this QR code biotinylated r-Hu-EPO staining revealed it to be cleared from the to view the article: NEUROSCIENCE

252 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com GENERAL SURGICAL such asourrodentrestrainers,collarsandanimalhandling With thisinmind,HarvardApparatushascompiledafew Every surgeryorprocedurerequiresaccessoryequipmenttohelpgetthejobdone. BiteNot ElizabethanCollars. RabbitRestrainers. Collars SmallAnimalSnuggle. RodentRestraintCones. RodentRestraintBags. PillowCollars. NEW AnimalHandingGloves. CervicalCollars. HeatedandUnheatedRodentRestrainers. Restrainers PRODUCT ® Collars...... of ourmorepopularaccessories, gloves. 254-257 257-258 261-262 PAGE 260 260 260 259 255 255 257

GENERAL SURGICAL RESTRAINERS

Red Tube Restrainers

Heated/Unheated Rodent Restrainers Clear Tube Restrainers

• Digital heater controlled restrainers • Sizes range from mouse to large rat • Hysteresis so no temperature overshoot • Available in red and clear Perspex. • Adjustable nose cone ensuring animal stays in correct position

Introducing the new Harvard Apparatus Heated Rodent Restrainers. We offer a full range of clear or red tube type restrainers for Order # Product maintaining animal body temperature while the animal is securely Restrainer Heater Controller: restrained. The restrainers have a sliding tail gate and nose cone ST1 40-3042 Restrainer Heater Controller, 115 VAC, 60 Hz to ensure the animal is unable to turn in the tube. This design also ST1 40-3041 Restrainer Heater Controller, 220 VAC, 50 Hz leaves the tail available for many applications including infusion, ST1 40-3040 Restrainer Heater Controller, 230 VAC, 50 Hz NIBP, tail vein cannulation and tail bleed. Clear Tube Restrainer: The heated restrainers will maintain an animal at a temperature ST1 40-3050 Mouse Restrainer, 20-30 g, clear between 35° to 45°C (95° to 113°F). They have a heat mat that ST1 40-3051 Rat Restrainer, 75-125 g, clear attaches to the bottom of the restrainer via a very strong bonding ST1 40-3052 Rat Restrainer, 100-150 g, clear adhesive ensuring it will stay in place. The animal does not come ST1 40-3053 Rat Restrainer, 150-350 g, clear into contact with the heater. The heat mats are designed to fit the ST1 40-3054 Rat Restrainer, 350-500 g, clear restrainers on this page. ST1 40-3055 Rat Restrainer, 500-750 g, clear A temperature sensor mounted close to the heating element Red Tube Restrainer: monitors the restrainer temperature, which is indicated on a large ST1 40-3008 Mouse Restrainer, 20-30 g, red easy to view red LED display on the heater controller. The desired ST1 40-3009 Rat Restrainer, 75-125 g, red temperature can be set easily on the front panel of the heater ST1 40-3010 Rat Restrainer, 100-150 g, red controller. The set and actual temperatures can be viewed on the Rat Restrainer, 150-350 g, red LED display. The display also indicates when the restrainer is being ST1 40-3011 heated. A variable hysteresis loop allows the user to tailor the ST1 40-3012 Rat Restrainer, 350-500 g, red heating characteristics of the unit to minimize heating overshoot. ST1 40-3013 Rat Restrainer, 500-750 g, red Heat Mat: The Harvard Apparatus Heated Rodent Restrainers are available in ST1 40-3043 Heat Mat for Mouse Restrainers red and clear Perspex, in a variety of sizes. The red tubes are widely (ST1 40-3050 & ST1 40-3008) thought to reduce stress of the animal while they are physically ST1 40-3044 Heat Mat for 75-125 g Rat Restrainers restrained. (ST1 40-3051 & ST1 40-3009) SURGICAL GENERAL A complete system consists of a heater controller, restrainer and ST1 40-3045 Heat Mat for 100-150 g Rat Restrainers (ST1 40-3052 & ST1 40-3010) heat mat. All system components must be ordered separately. If you would like a non-heated restrainer simply just purchase the ST1 40-3046 Heat Mat for 150-350 g Rat Restrainers (ST1 40-3053 & ST1 40-3011) appropriate restrainer.

ST1 40-3047 Heat Mat for 350-500 g Rat Restrainers (ST1 40-3054 & ST1 40-3012) ST1 40-3048 Heat Mat for 500-750 g Rat Restrainers (ST1 40-3055 & ST1 ST1 40-3013)

254 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com RESTRAINERS

Broome Rodent Restrainers Triangle Rodent Body Contour™ Rodent Restraint Bag Restraint Bag

Rodent Restraint Bags

• Variety of sizes and shapes • Multiple colors Broome Rodent Restrainers • Safe, humane and disposable • Perfect for injections or blood sampling • Includes twist ties to secure bags • Entire tail is completely exposed for injections • Multi-use or sampling These Rodent Restraint Bags constructed of Easy-Flex-PE™ These popular Broome Rodent Restrainers provide fast and easy provide effortless wrapping and added animal comfort. Pre-cut animal insertion. The cylindrical design of these restrainers solves sizing eliminates the need for cutting down larger bags for smaller the problem of the rodents turning once they are introduced into animals, and the optional Body-Contour™ cone shape provides the restrainer. easier animal capture and restraint and increased animal comfort. Optional black and rose color bags reduce natural light to provide an environment that aids in reducing animal agitation and stress. Animal Restraining Length Restraint bags can be used in a variety of procedures including tail Order # Weight Range Barrel ID Min x Max tattooing and injections, IP injections, oral dosing and decapitation. ST1 52-0460 15 to 30 g 25.4 mm (1 in) 41 x 83 mm (1.6 x 3.3 in)

1 ST1 52-0470 30 to 70 g 31.75 mm (1 ⁄4 in) 50 x 100 mm (2 x 3.9 in) 1 Clear Black Rose Animal ST1 52-0478 70 to 125 g 38 mm (1 ⁄2 in) 73 x 124 mm (2.9 x 4.9 in) Order # Order # Order # Size Mass ST1 52-0486 125 to 250 g 50.8 mm (2 in) 70 x 178 mm (2.8 x 7 in) Body-Contour™ Shape, pkg. of 40: 1 ST1 52-0494 250 to 500 g 63.5 mm (2 ⁄2 in) 58 x 195 mm (2.3 x 7.7 in) ST1 72-6400 ST1 72-6401 ST1 72-6402 Small 120 g ST1 72-6403 ST1 72-6404 ST1 72-6405 Medium 225 g ST1 72-6406 ST1 72-6407 ST1 72-6408 Large 450 g ST1 59-6409 Rodent Rodent Injection Cone Injection Cone Traditional Triangle Shape, pkg. of 50: This Injection Cone is useful ST1 72-6409 – – X-Small < 20 g for large quantity sampling ST1 72-6410 ST1 72-6411 ST1 72-6412 Small 120 g where speed and efficiency are ST1 72-6413 ST1 72-6414 ST1 72-6415 Medium 225 g required. It is transparent, durable ST1 72-6416 ST1 72-6417 ST1 72-6418 Large 450 g and easy-to-clean. Suction cup feet prevent the Cone from slipping on the work surface. The Rodent Restraint Cones Cone opening is 10.2 cm (4 in) ST1 52-9586 Rodent 3 Restraint Cones in diameter and is 14.6 cm (5 ⁄4 in) long. Restrains animals from 15 to These clear polyfilm disposable 600 grams. Rodent Restraint Cones are an economical way to hold Order # Product and restrain rodents. Place ST1 59-6409 Rodent Injection Cone the animal into the cone and close the large end. The animal breathes through an opening in the small end. Animal waste is contained in the cone. Deliver injections directly through the plastic. Restraint cones can be reused. Sold in packages of 100.

Order # Product ST1 52-9586 Rodent Restraint Cones, pkg. of 100 GENERAL SURGICAL

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Tube Type Holders Universal Rodent Restrainers

Universal Rodent Restrainers Tube Type Holders

• Restrain mice down to 10 grams! No. of • Removable raised inner floor Weight Outer Tube Inner Diameter of Order # Range Diameter Tubes Inner Tubes • Adjustable headgate and removable tailgate ST1 34-0012 20 to 50 g 30 mm (1.2 in) 1 24 mm (0.95 in) • Headgate fits into any of four positions for various sizes ST1 34-0007 150 to 300 g 57 mm (2.2 in) 1 44 mm (1.7 in) of rodents ST1 34-0008 150 to 400 g 68 mm (2.7 in) 2 57 mm, 44 mm • Tailgate allows maximum closeness of occluding cuff to (2.3 in, 1.7 in) body when testing indirect blood pressure ST1 34-0009 300 to 500 g 94 mm (3.7 in) 2 57 mm, 57 mm (2.3 in, 2.3 in) These Universal Rodent Restrainers have a unique raised inner ST1 34-0010 500+ g 121 mm (4.8 in) 2 94 mm, 68 mm floor which provides a better fit for smaller rodents and which (3.7 in, 2.7 in) may be removed for larger rodents. The inner floor is attached * Note: Replacement thumb screws available, please call. There are no holes to the bottom by two nylon screws. Knurled, nickel-plated brass on bottom of tube type holders. Holes can be drilled for IP or tail vein screws serve as base fasteners and legs. These Universal Rodent injections by special order. These holders have a removable inner tube. 1 Restrainers are constructed of 6.4 mm ( ⁄4 in) thick, rigid, clear acrylic plastic. Openings in the headgate reduce restrictions on the Box Type Holder Cone Type Holder Angle Type Holder rodent’s breathing. Not autoclavable.

Animal Weight Restraining Order # Range Area, Minimum H x L Maximum ST1 56-4499 10 to 40 g 28.6 x 51 mm 41.3 x 102 mm 1 5 (1 ⁄8 x 2 in) (1 ⁄8 x 4 in) ST1 56-4500 150 to 300 g 41.3 x 124 mm 54 x 171 mm 5 7 1 3 (1 ⁄8 x 1 ⁄8 in) (2 ⁄8 x 6 ⁄4 in) ST1 56-4501 250 to 600 g 47.6 x 152 mm 60.3 x 216 mm Order # Product 7 3 1 (1 ⁄8 x 6 in) (2 ⁄8 x 8 ⁄2 in) ST1 34-0029 Box Type Holder ST1 34-0030 Cone Type Holder, Large ST1 34-0031 Cone Type Holder, Small ST1 34-0033 Angle Type Holder, Small

Single Tube Holder with Access Holes

The Single Tube Holder with Access Holes has been developed to improve access to various parts of the body while still restraining the animal. The single tube holder is available with internal tube diameters of 25 mm, 33 mm, 45 mm, 57 mm, 69 mm and 94 mm (lengths rising proportionately). Length can be adjusted by means SURGICAL GENERAL of a cone inside the tube. Holes can be cut into the holder at any position to the size and shape of your choice. The single tube holder is made in Perspex and is flame polished. Each customer’s design is given its own unique code for re-ordering purposes.

For rodent infusion, injection and dosing, see page 109. Order # Product ST1 34-0011 Single Tube Holder with Access Holes

256 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com RESTRAINERS

Flat Bottom Bunny Snuggle Restrainers

Flat Bottom Restrainers Small Animal Snuggle

• Adjustable tail gate; fixed head gate • Less stress than rigid restrainers • Feeding pocket • Effective yet comfortable restraint • Bottom slot for easy access for injections • Multiple flaps facilitate many restraint configurations for various procedures: These Flat Bottom Restrainers have one circular opening on top – blood collection, vaginal samples, veterinary exams, and a slot on the bottom for easy intramuscular, intraperitoneal and gavage, eye movement, transportation intravenous injections and drainage of wastes. The adjustable tail gate fits in one of 4 slots, allowing the re­strainer to accommodate • Velcro fasteners for quick and easy application different sized animals. The front of the restrainer has two slots for and removal easy breathing and anesthetizing. The bottom extends past the front part of the restrainer forming a pocket for animal feeding. Introducing the safest form of small animal restraint to date, the snuggle! Manufactured of flexible yet durable nylon coated canvas, the snuggle is rugged enough for repeated laundering and reuse. Weight Restraining Restraining Length It may be gas sterilized if desired. Wide flaps with hook and loop Order # Range Height Minimum Maximum fasteners provide maximum flexibility and ease of use allowing for a ST1 52-0882 15 to 30 g 25.4 mm 44.5 mm 76.2 mm 3 custom fit between individual subjects. (1 in) (1 ⁄4 in) (3 in) ST1 52-0890 30 to 125 g 38.1 mm 63.5 mm 101.6 mm A fragile bone structure coupled with the high tendency of stress in 1 1 (1 ⁄2 in) (2 ⁄2 in) (4 in) small animals lends to the continuous risk of fractures with the use ST1 52-0908 125 to 250 g 44.5 mm 76.2 mm 127 mm of traditional rigid restraints. Mechanical restraints also frequently 3 (1 ⁄4 in) (3 in) (5 in) require the involvement of two personnel; one to restrain and one ST1 52-0916 250 to 500 g 50.8 mm 108 mm 171.5 mm to perform the procedure. The resulting stress and discomfort for 1 3 (2 in) (4 ⁄4 in) (6 ⁄4 in) the rabbit can often jeopardize the efficiency of the procedure and consistency of results. The snuggle acts as a swaddling for an effective yet comfortable restraint, rather than a rigid structure for immobilization. The multiple flaps lend to many restraint configurations to provide access depending on the procedure. One handler can carry out both restraint and procedures easily with the snuggle. The snuggle is available for rodents, guinea pigs and rabbits, order Fully Adjustable Acrylic Rabbit Restrainers according to the weight range of the animals.

Fully Adjustable Acrylic Rabbit Restrainer Order # Product ST1 72-0020 Bunny Snuggle, Small, up to 3.5 kg • Extra long curved back plate with adjustable height ST1 72-0021 Bunny Snuggle, Medium, 3.0 kg to 5.0 kg • For 3 to 7.5 kg (6.6 to 16.5 lb) rabbits ST1 72-0022 Bunny Snuggle, Large, 5.0 to 7.0 kg ST1 72-6274 Bunny Snuggle, X-Large, over 7.0 kg The back plate of this restrainer is divided into two separate ST1 72-6270 Guinea Pig Snuggle, Small, up to 350 g adjustable pieces, a curved back plate and a rear plate, providing ST1 72-6271 Guinea Pig Snuggle, Medium, 350 g to 600 g a perfect fit with no gaps. The back height is adjustable from a ST1 72-6272 Guinea Pig Snuggle, Large, 600 g to 750 g 1 minimum of 11.4 cm (4 ⁄2 in) to a maximum of 17.8 cm (7 in) and ST1 72-6273 Guinea Pig Snuggle, X-Large, over 750 g is secured by tightening 4 knobs. The rear plate has an extra ST1 72-6265 Rodent Snuggle, X-Small, 100 g to 150 g extension plate that can slide up to match the height of the back plate for securely restraining the animal. ST1 72-6266 Rodent Snuggle, Small, 150 g to 250 g ST1 72-6267 Rodent Snuggle, Medium, 250 g to 350 g

ST1 72-6268 Rodent Snuggle, Large, 350 g to 500 g GENERAL Order # Product SURGICAL ST1 72-6269 Rodent Snuggle, X-Large, over 500 g ST1 59-6947 Fully Adjustable Acrylic Rabbit Restrainer

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ST1 52-6673 Polycarbonate Rabbit Restrainer ST1 52-0932 Acrylic Rabbit Restrainer

Polycarbonate Rabbit Restrainer Acrylic Rabbit Restrainers

• Completely autoclavable polycarbonate with • Curved back plate minimizes injury stainless steel parts • Adjustable vertical head restraint bars prevent rabbit from • Adjustable neck support, rear plate and unique moving head from side-to-side during ophthalmological top plate which protects rabbit’s spine studies • This restrainer is only for rabbits weighing 1 These transparent Acrylic Rabbit Re­strainers have highly polished from 3 to 4.5 kg (5 ⁄2 to 10 lb) edges to prevent chaffing, especially at the neck. A durable, non- The rabbit is secured as follows: slip floor provides firm footing yet doesn’t tear foot pads upon Remove rear plate and top plate. removal. Open hinged top and place The neck plate is bisected horizontally. The top half of the neck rabbit inside. Each side of the plate vertically slides within slots and locks into place. The neck 3 1 restrainer has five 7.6 cm (3 in) opening adjusts from 4.4 to 6.4 cm (1 ⁄4 in to 2 ⁄2 in) diameter. slots separated by approximately 1 1 1 2 8 3.2 cm (1 ⁄4 in). Slide rear plate Two 19 cm (7 ⁄ in) high, 2.9 cm (1 ⁄ in) thick head restraint bars 3 in appropriate slots for size of slide horizontally to restrain the head from 3.5 to 7.3 cm (1 ⁄8 in to 7 animal. The rear plate has a (2 ⁄8 in). They are secured by tightening two large knobs and are slotted opening for pyrogen removable if needed. ST1 52-6681 testing. Slide and lock in place 5 The sliding back plate has a 4.1 cm (1 ⁄8 in) access hole and curved 2.5 cm (1 in) wide top is secured by tightening a nylon screw against the floor. Not plate in appropriate slot over animal’s back to prevent injury. Close autoclavable; sterilize chemically or wash up to 82°C (180°F). the hinged top; latch the front of the restrainer. The overall length for each restrainer is 45.7 cm (18 in). Slide the neck plate up and secure by turning two black knobs to 1 adjust the 5.8 cm (2 ⁄4 in) wide neck opening from a minimum of 5.1 cm (2 in) to a maximum height of 7.5 cm (3 in). To protect the Weight Restraining Restraining Length Order # Range Width Minimum Maximum animal’s neck, install the polypropylene half neck collar (supplied) ST1 52-0924 Up to 4 kg 15.2 cm 34 cm 38 cm on the upper part of the neck opening. This further reduces 1 (8.8 lb) (6 in) (13 ⁄2 in) (15 in) the height of the neck opening to 4.1 cm (1.6 in). The minimum ST1 52-0932 4 to 7 kg 15.2 cm 36.3 cm 48.9 cm restraining length is approximately 23 cm (9 in) and the maximum 1 1 (8.8 to 15.4 lb) (6 in) (14 ⁄4 in) (19 ⁄4 in) restraining length is 38 cm (15 in).

1 1 The base has a 26.7 x 10.8 cm (10 ⁄2 x 4 ⁄4 in) stainless steel floor grid insert with inverted ‘U’ shaped bars for paw comfort and firm footing. Animal wastes drop into either the 12.7 x 29.8 cm 3 (5 x 11 ⁄4 in) plastic tray provided or tray in Six-Cage Stand, listed below.

Order # Product SURGICAL GENERAL ST1 52-6673 Polycarbonate Rabbit Restrainer ST1 52-6681 Six-Cage Stand for up to six ST1 52-6673 Restrainers (not included); a front shelf holds instruments; front casters lock for added security;

H x W x D, 91 x 150 x 94 cm (36 x 59 x 37 in); 22.7 kg (50 lb)

258 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com COLLARS

The Lightweight Collars with hook and loop Closure for Rodents Elizabethan Collars allow the collar to be snugly adjusted. (Not suitable for mice, with Snap Fasteners see below.) The lightweight collars for rabbits have one row of 3 rustproof snap fasteners mounted halfway between the inner and outer edge of the collar. These fasteners provide adjustment of the neck opening. The standard collars for rabbits, cats and dogs have 6 rustproof snap fasteners, 3 mounted on the inner edge and 3 on the outer edge of the collar, to adjust the neck opening. Select a collar based on the animals neck circumference and desired collar width. Collars available for cats and dogs. Please contact technical support for Elizabethan Collar more information. with hook and loop Closure Order # Neck Circumference Collar Depth Weight Lightweight Collars with hook and loop Closure for Rodents:

1 1 ST1 59-6412 5.7 to 7.6 cm (2 ⁄4 to 3 in) 3.2 cm (2 ⁄4 in) 5.7 g

1 1 Elizabethan Collars ST1 59-6413 5.7 to 7.6 cm (2 ⁄4 to 3 in) 3.5 cm (1 ⁄8 in) 7.0 g 1 ST1 59-6414 7.6 to 10.2 cm (3 to 4 in) 3.8 cm (1 ⁄2 in) 7.0 g • Prevents animals from grooming and dislodging implants Lightweight Collars with Snap Fasteners for Rabbits: 1 1 saving time and money ST1 59-6427 5.7 to 7.6 cm (2 ⁄4 to 3 in) 5.7 cm (2 ⁄4 in) 14.2 g 1 • Easily adjustable to properly fit different animals ST1 59-6428 7.6 to 10.2 cm (3 to 4 in) 5.4 cm (2 ⁄8 in) 14.2 g 1 ST1 59-6429* 7.6 to 10.2 cm (3 to 4 in) 7.9 cm (3 ⁄8 in) 21.3 g • Tried and true – thousands in use today 1 7 ST1 59-6430 10.2 to 13.3 cm (4 to 5 ⁄4 in) 7.3 cm (2 ⁄8 in) 21.3 g

1 7 These low density polyethylene Elizabethan Collars are both tough ST1 59-6431* 10.2 to 13.3 cm (4 to 5 ⁄4 in) 9.8 cm (3 ⁄8 in) 35.4 g 1 1 1 for durability and soft and pliable enabling the animal to eat, drink, ST1 59-6432 11.4 to 15.9 cm (4 ⁄2 to 6 ⁄4 in) 8.9 cm (3 ⁄2 in) 35.4 g 1 1 3 and move about comfortably. The neck opening is padded with soft ST1 59-6433* 11.4 to 15.9 cm (4 ⁄2 to 6 ⁄4 in) 11.1 cm (4 ⁄8 in) 42.5 g

1 1 1 vinyl foam. ST1 59-6434 15.9 to 23.5 cm (6 ⁄4 to 9 ⁄4 in) 10.5 cm (4 ⁄8 in) 42.5 g Three types are available: *Note: These collars have two rows of snap fastners. - Lightweight, 0.5 mm (0.020 in) thick collars for rodents with hook and loop closure - Lightweight, 0.5 mm (0.020 in) thick collars for rabbits with one row of snap fasteners - Standard, 1.5 mm (0.060 in) thick collars for rabbits, cats, and dogs with two rows of snap fasteners

Mouse Elizabethan Collar

• Specially designed for mice

Designed specifically for the mouse, this collar is low-density, light- weight polyethylene. The neck is bound with cotton jersey material for added comfort. Hook and loop fasteners ensure full adjustment for mice weighing ≥ 15 grams.

Order # Product

1 ST1 72-0056 Mouse Elizabethan CollarID ⁄2 in, OD 3 in, Thickness 0.2 in

GENERAL For jackets and slings, see pages 129-133. SURGICAL

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ST1 61-0229 BiteNot® Collar for Cats

Cervical Collars for Cats and Dogs

Cervical Collars

• For canines and cats • Similar in function to Elizabethan Collars but more effective for housing space

These Cervical Collars restrict the movement of the animal’s head from side-to-side while permitting downward motion for feeding. These pliable Collars are made from low density polyethylene with light padding around the edges to soften the contours. Available with a choice of widths to accommodate different neck heights. The hook and loop strip provides continuous adjustment to securely fit the neck.

Animal Collar Size Width Circumference* Canines:

® 1 1 BiteNot Collars ST1 59-9194 Sm (3 ⁄4) 8.25 cm (12 ⁄2 in) 31.8 cm (12.5 in)

3 ST1 59-9195 Med (3 ⁄4 in) 9.5 cm (14 in) 35.6 cm (14 in) • More comfortable than Elizabethan Collars ST1 59-9196 Lg (5 in) 12.7 cm (15 in) 38.1 cm (15 in) • Less restrictive to the animal’s natural behavior so animal Cats: stays calmer 1 ST1 59-9197 Sm (1 ⁄4 in) 3.2 cm (5 in) 12.7 cm (5 in)

1 1 ST1 59-9198 Med (1 ⁄2 in) 3.8 cm (5 ⁄2 in) 14.0 cm (5.5 in) Introducing the first alternative to the Elizabethan Collar that is a 3 comfort to wear. These BiteNot® Collars are a revolutionary product ST1 59-9199 Lg (1 ⁄4 in) 4.4 cm (6 in) 15.2 cm (6 in) that allow dogs and cats to eat, drink, sleep and play, comfortably. * Note: Other Collar circumferences available upon request. Peripheral vision is unimpeded so dogs and cats are calmer and happier. The BiteNot® Collar wraps snugly around the animal’s neck and should be wide enough to extend from behind the ear to the top of the shoulder. These collars protect the back, rump, base of the tail, flanks, chest, abdomen, genitals and even the feet (not recommended for protecting the eyes or ears). They are made of flexible, polyethylene plastic covered in foam on one side for comfort and to prevent slippage. They are secured by hook and loop strips along the edges and have an elastic wraparound strap.

Weight of Order # Collar Size Animal Collar, W x L ST1 61-0224 Dog, Size 1 Under 10 lbs 89 x 406 mm (3.5 x 16 in) ST1 61-0225 Dog, Size 2 10 to 17 lbs 102 x 457 mm (4 x 18 in) ST1 61-0226 Dog, Size 3 18 to 30 lbs 127 x 533 mm (5 x 21 in) ST1 61-0231 Dog, Size 3 31 to 45 lbs 127 x 610 mm (5 x 24 in) ST1 61-0232 Dog, Size 4 46 to 70 lbs 152 x 686 mm (6 x 27 in) ST1 61-0227 Dog, Size 5 71 to 100 lbs 178 x 711 mm (7 x 28 in) ST1 61-0228 Dog, Size 6 101 to 140 lbs 203 x 813 mm (8 x 32 in) Pillow Collars SURGICAL

GENERAL ST1 61-0229 Cat, Size Small Under 10 lbs 63.5 x 356 mm (2.5 x 14 in) These Pillow Collars are designed for a wide range of applications ST1 61-0230 Cat, Size Large Over 10 lbs 76 x 381 mm (3 x 15 in) in both dogs and rabbits. They are manufactured from an * Note: The bottom of the collar must touch the animal’s shoulder joint for extremely durable “ballistic” canvas fabric with a foam pillow maximum protection. For proper sizing measure from the back of the ear to inside the casing. These collars are available for use with dogs and the shoulder joint and select the collar with a corresponding width. rabbits in either black or white. For complete details and ordering information, see page 129. BiteNot is a registered trademark of Bite Not Products Inc.

260 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com GLOVES

T/Flex® Plus Animal Triple-Strength Handling Gloves Gloves

T/Flex® Plus Animal Handling Gloves Triple-Strength Gloves

• Highest cut resistance • Improved cut resistance • Elastic wrist band allows for an accurate, comfortable • Comfortable and lightweight and safe fit • Unmatched durability • Comfortable and safe • Not puncture proof

The T/Flex® Plus Small Animal Handling Gloves are a unique These gloves provide excellent protection, less weight and greater and innovative integration of comfort and technology. These dexterity. They are seamless and are knit from a yarn that has a gloves are a 13 gauge seamless knit shell; material is Dyneema® central core of stainless steel wire covered in Kevlar (the material engineered fibers plated with Lycra® – Spandex®, Thermax® and used in bullet proof vests). An additional layer of Spectra nylon the antimicrobial treatment Alphasan® combine to provide a increases strength, comfort and durability, while decreasing skin comfortable glove featuring the highest cut resistance. Gloves chafing. They are not puncture proof, but are highly cut-resistant. conform to international safety standards for cut resistance, They are machine washable. with a 4 out of 5 slash resistance score. These five-finger gloves have a snug, 7.5 cm (3 in) cuff for These gloves are designed and fabricated for flexibility, accurate protection. They are offered in three sizes and are sold in pairs. touch control, comfort and safety during long periods of wear. Elastic wrist band allows for an accurate, comfortable and safe fit. Wear these gloves over a pair of leather gloves for the utmost protection.

Order # Product ST1 72-6281 T/Flex Plus Animal Handling Gloves, X-Small, Pair Order # Product ST1 72-6275 T/Flex Plus Animal Handling Gloves, Small, Pair ST1 52-6780 Triple-Strength Gloves, Small, Pair ST1 72-6282 T/Flex Plus Animal Handling Gloves, Medium, Pair ST1 52-6798 Triple-Strength Gloves, Medium, Pair ST1 72-6276 T/Flex Plus Animal Handling Gloves, Large, Pair ST1 52-6806 Triple-Strength Gloves, Large, Pair ST1 72-6283 T/Flex Plus Animal Handling Gloves, X-Large, Pair

GENERAL SURGICAL

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Stainless Steel Small Animal Handling Mesh Gloves Deerskin Gloves

• Deerskin leather, thin yet strong and durable • Lined with Kevlar for slash resistance • Adjustable hook and loop wrist strap • Soft and form fitting, will not crack or harden after wetting

These Small Animal Handling Deerskin Gloves offer a smart solution for protection during long periods of wear. When handling small animals, dexterity coupled with protection is vital for the security of both the subject and handler. Manufactured from a soft yet durable deerskin, these gloves are adjustable for a secure and comfortable fit and lined with knitted Kevlar to provide extra protection and slash resistance.

Order # Product ST1 72-6277 Deerskin Gloves, Small Pair Deerskin Gloves, Medium Pair Stainless Steel Mesh Gloves ST1 72-6278 ST1 72-6279 Deerskin Gloves, Large Pair • 3-step reversible design to make glove suitable for right ST1 72-6280 Deerskin Gloves, X-Large Pair or left hand • Ergonomic design for optimal comfort and fit Primate Handling • Highest level of protection in cutting operations Leather Gloves • Hygienic & easily sanitized with Kevlar Lining • Straps are made from anti-microbial polypropylene fibers • Largest range of sizes • Replaceable polypropylene straps of animal handling gloves These five-finger Stainless Steel Mesh Gloves offer protection • Kevlar lining against animal bites and knife cuts. Sharp teeth longer than provides unparalleled 1 3.2 mm ( ⁄8 in) will penetrate the Glove. Constructed from protection against individually welded stainless steel links, these Gloves are extremely punctures rugged and durable while allowing full mobility of the hand and wrist. The Gloves are secured by quick-releasing hook and loop These 100% full grain cowhide straps. These straps can be removed for autoclaving, or the entire gloves have split grain cuffs Glove may be cleansed with soap and water. that are 25.5 cm (10 in) long. These Gloves are offered in two styles. The first style has a single These rugged gloves are hook and loop strap at the wrist. The second style has an additional available in five sizes either hook and loop strap and a 8.9 cm (3 in) safety cuff for added wrist with or without the Kevlar protection. Both styles are reversable. They are sold individually. lining. They are provided in pairs. Full grain leather Snap- On Over Gloves are available Glove Size Without Safety Cuff With Safety Cuff separately and easily attach X-Small ST1 72-9966 ST1 72-9972 to the glove via sturdy snaps. Small ST1 72-9967 ST1 72-9973 These over gloves provide a second layer of leather over the Medium ST1 72-9968 ST1 72-9974 thumb and index finger for additional protection when working Large ST1 72-9969 ST1 72-9975 with primates. X-Large ST1 72-9970 ST1 72-9976 With Kevlar Without Kevlar Snap-On SURGICAL 2X-Large ST1 72-9971 ST1 72-9977 GENERAL Glove Size Lining Lining Over Glove Small ST1 72-4016 ST1 72-4020 ST1 72-4024 Medium ST1 72-4017 ST1 72-4021 ST1 72-4025 Large ST1 59-9186 ST1 59-9187 ST1 59-9188

X-Large ST1 72-4018 ST1 72-4022 ST1 72-4026 XX-Large ST1 72-4019 – –

262 To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com INDEX

PRODUCT PAGE PRODUCT PAGE

A Anesthetizing Boxes...... 174-175 Anesthetic/CO Chambers...... 175 Advisor Vital Signs Monitor...... 205 2 CO Chambers with Dump Door...... 174 Aerosol Nebulizers, see Nebulizers 2 Amplifiers & Housings...... 217-218 Induction Chamber...... 174 ISO510A Transducer Amplifier...... 218 Animal Feeding Needles...... 140-142 PLUGSYS Case 601...... 217 APT 300 Transducers...... 210, 228 PLUGSYS Case 603...... 217 Artificial CSF...... 248 PLUGSYS Minicase...... 217 TAPi...... 218 Transducer Amplifier TAM-A and TAM-D...... 217 Anesthesia Accessories...... 168-169, 175-184 B Adapters, Non-Rebreathing...... 168 Adapters, Respiratory...... 184 Balances and Scales...... 107-108 Adapters, Halovet...... 184 Animal Weighing System...... 108 Battery Operated Portable Scale...... 107 Freestanding CO2 Absorber System...... 168-169 Mayo Tray...... 169 Triple-Beam Balance...... 107 Quick Release Fitting, Female...... 175 Biopsy Ear Punch...... 105 Quick Release Fitting, Male...... 175 Biopsy Punches, Micron...... 250 Tubing...... 184 Blood Flow...... 225-227 Tubing, Coiled 6 mm...... 175 Blood Pressure...... 205, 209-223 Tubing, Flexible...... 184 Advisor Vital Signs Monitor...... 205 Tubing, Pneumatic 6 mm...... 175 APT 300 Transducers...... 210, 228 Wall Mounting Kits...... 168 Calibrator, Electronic Pressure...... 219 Z-Bracket Universal Vaporizer Mounting Bracket...... 169 Calibrator, Manual Pressure...... 219 Anesthesia Equipment...... 157-184 DTXPlus Sterile Disposable Transducer...... 212, 228 Anesthesia Machines...... 167-170 Millar MIKRO-Tip and Ultra Mini Catheters...... 214-216 Anesthetic Brackets...... 168 Millar Pressure Transducer Accessories...... 216 Basic Table-Top Anesthesia Machine...... 168 Millar SPR Catheters & TC 510 Control Unit...... 216 CDS9000 Small Anesthesia Machine...... 167 NIBP MC4000 Multi-Channel...... 223 Mobile Post System...... 169 NIBP System from Panlab...... 220-221 Modular Anesthesia Trolley System...... 170 NIBP System SC1000...... 222 Multiple Animal System...... 170 P75 Venous Pressure Transducer...... 213, 228 Vaporstick Anesthesia Machine...... 169 Research Grade Pressure Transducer...... 209 Sterile Single Use Pressure Sensor...... 211, 228 Anesthesia Systems, Fluovac, Two Animal...... 162-163 TRA 021 Transducer - Panlab...... 211, 228 Fluovac System Mice...... 162 Transducer Amplifier, HA LT TAPi...... 218 Fluovac System Mice with Small Induction Box...... 163 Transducer Amplifier, HSE TAM-A and TAM-D...... 217 Fluovac System Rats...... 162 Transducer Amplifier, Panlab ISO 510A...... 218 Fluovac System, Small Animal Bone Cutting Forceps...... 7 with Large Induction Box...... 163 Bone Rongeurs...... 7 Anesthesia Systems, Mobile...... 160-161 Bone Wax...... 53 Mobile Anesthesia System with Induction Box...... 161 Bulldog Clamps...... 45 Mobile Single Animal System...... 160 Mobile Single Animal Anesthesia System with Small Induction Box...... 161 Trolley Anesthesia System...... 164 Anesthesia Systems, Table-Top, Single Animal...... 158-159 Single Animal Anesthesia System...... 158 Single Animal Anesthesia System with Small Induction Box..... C 159 Cage, Infusion...... 111 Single Animal Isoflurane System...... 158 Cannula...... 55 Single Animal Isoflurane System Aortic Cannulae to IH-5 System...... 55 with Small Induction Box...... 159 Aortic Cannulae to IH-SR System...... 55 Anesthetic Circuit Sets...... 172 Ball Joint Holder and Cannulating System Modified Jackson Rees (MJR) Circuit...... 172 for Pulmonary Artery...... 55 Rodent Circuit Set...... 172 Cannulae for Isolated Liver or Kidney Perfusion...... 55 Rodent Circuit Set Replacement Diaphragms...... 172 Capnography...... 205, 206-208 Universal Rebreathing Anesthesia F-Circuit...... 172 Advisor Vital Signs Monitor...... 205 Anesthetic Masks/Nose Cones...... 173 Capnograph Type 340...... 206 Canine Ventilation/Anesthesia Masks...... 173 V3395 Temperature, SpO & Respiration Monitor...... 207 Cat Ventilation/Anesthesia Masks...... 173 2 V8401 Capnocheck...... 207 Coax Breathing Apparatus...... 173 V9004 Series Intelligent Capnograph...... 208 Masks, Fluovac...... 180 CareFRESH Absorbent Sheets...... 89 Mouse Anesthetic Mask...... 173 Catheter Introducer...... 128 Rat, Guinea Pig and Bird Anesthetic Mask...... 173

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 263 INDEX

PRODUCT PAGE PRODUCT PAGE

Catheters...... 122, 125-128 ECG...... 225-230 Butterfly Catheter Infusion Sets...... 128 ECG, 12-Lead Einthoven...... 226 Dosing Catheters...... 139 ECG, 6-Lead Einthoven...... 225 Dosing Gags...... 139 ECG, Single Lead...... 225 Funnel-Cath Mouse Catheters...... 122 Electrodes...... 225-226, 229-230 Intrathecal Catheter...... 122 Electrodes, Disposable, Reusable, Accessories.....225-226, 229-230 Micro-Cannula...... 123 Endotracheal Tubes...... 192, 194 Portex Catheters...... 139 Standard Endotracheal Tubes...... 192 SoloCath Cathters...... 124-125 Endotracheal Tubes for Small Animals...... 194 Vein Pick Catheter Introducer...... 128 Etched Tungsten Micro-Needles...... 54 Cautery Kit...... 54 Evacuation & Scavenging...... 177-181 Gemini Cautery Kit...... 54 AES Gas Evacuation System...... 178 Clipper Blades...... 103 Down Draft Tables...... 177 Clippers, Animal...... 100-104 F/AIR Canister...... 178 Trimmer & Clippers ...... 100 Fluosorber Canisters...... 179 Vacuum Clipper System...... 100 Fluovac System...... 179-181 Clips & Clamps...... 44-47 Lab Animal Evacuation System...... 178 Bulldog Clamps...... 45 Scavenger Interface Valve for Active Systems...... 178 Flat Serrated Hook ...... 46 Heart Clips...... 46 Holder for Vessel Segments...... 47 Hook, Organ ...... 47 F Hooks, Triangular ...... 47 Flow Probes...... 227 Long Flat Jaw ...... 46 Flowmeters, Air...... 166-170 Long Jaw ...... 46 Flowmeters, Blood...... 225-227 Long Loop ...... 47 Fluid Warming Cabinet...... 89 Micro Aneurysm ...... 44 Fluovac System...... 179-181 Micro Vascular ...... 44 Directavalve...... 180 Pointed Jaw ...... 46 Fluosorber Canisters...... 179 Serre Fine Tip Closing ...... 47 Fluovac Anesthetizing Chambers and Systems...... 181 Thread Connection ...... 46 Fluovac Exhaust Tube Mount...... 179 Tissue...... 46 Fluovac Isolator Valve...... 180 Vessel...... 45 Fluovac Mask Support...... 179 Collars...... 259-260 Fluovac Tube Restrainer ...... 181 Bite Not Collars...... 260 Gas Flow Director...... 176 Cervical Collars...... 260 Masks, Fluovac...... 180 Elizabethan Collars...... 259 Portable Scavenged Anesthesia Table for Mice...... 180 Pillow Collars...... 129, 260 Scavenged Anesthetizing Chambers...... 181 Connection Kits for Anesthesia...... 192 Forceps...... 22-34 Controlled Environments...... 86-89 Cover Glass...... 26 Fluid Warming Cabinet...... 89 Dressing...... 28-29 Small Animal Intensive Care Units...... 86-87 Hemostatic...... 31-34 Small Animal Recovery Chamber...... 89 Iris...... 23-25 Thermal Barrier...... 88 Jewelers...... 27-28 Vetcare Heated Chamber System...... 88 Micro...... 30 Warm Air Chamber...... 87 Suture...... 26 CSF Fluid Replacement...... 248 Tissue...... 22-23 Fur Removal Products...... 100-104 Trimmers & Clippers ...... 100-104 D Vacuum Clipper System...... 104 Data Acquisition...... 198-201 ADInstruments Powerlab...... 199 LabChart Modules...... 200-201 G Decapitators...... 56 Gas Delivery...... 172-176 Delivery & Sampling...... 109-156 Directional Manifold...... 172 Dissesting Sponges...... 53 Gas Blenders...... 203 Dosing Catheters ...... 139 Gas Flow Director...... 172 Dosing Gags...... 139 Manifolds...... 172 Drapes, Surgical...... 52 Gemini Cautery Kit...... 54 Drug Delivery Capsules...... 154-155 General Surgical...... 253-262 Gloves, Animal Handling...... 261-262 Primate Leather Gloves with Kevlar Lining...... 262 E Small Animal Handling Deerskin Leather Gloves...... 262 Stainless Steel Mesh Gloves...... 262 Ear Punch...... 105 T/Flex Plus Animal Handling Gloves...... 261 Ear Tags...... 105 Triple Strength Gloves...... 261 Ear Tags, Miniature Brass...... 105 Guillotine...... 56

264 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com INDEX

PRODUCT PAGE PRODUCT PAGE H J Heat Lamp ...... 76 Jackets & Slings...... 129-133 Heat Therapy Pumps and Pads...... 70 Ferret Jackets...... 129 Homeothermic Blanket Systems...... 58-59 Guinea-Pig Jacket...... 129 Hook, Micro Dissecting...... 8 Large Animal Jackets...... 130 Hooks, Triangular...... 47 Large Animal Restraint Unit...... 133 Hot Bead Sterilizer...... 49 Large Animal Sling Suits and Frames...... 132 Rat, Hamster, & Mouse Jackets...... 129 Rhesus Primate Jackets...... 131 I Rodent Sling Suits and Frames...... 132 Identification Products...... 105-106 Biopsy Ear Punch...... 105 Ear Punch...... 105 K Micro-Tattooing System...... 106 Miniature Brass Ear Tags...... 105 Kevlar Gloves...... 262 Small Animal Ear Tags and Applicator...... 105 Knife, Micro Dissecting...... 8 Tattoo Pigment...... 106 Tattoo Set...... 106 Induction Chambers...... 174-175

Anesthetic/CO2 Chambers...... 175 Anesthetizing Boxes...... 174 L CO2 Chambers with Dump Door...... 174 Laryngoscopes, see Intubation Equipment Infusion...... 111-119, 126-128 Butterfly Catheter Infusion Sets...... 128 Cage...... 111 Swivels...... 112-115 Tethers...... 116-119 Tubing & Connectors...... 126-127 M Infusion Guide, Rodent...... 110 Magnification...... 90-93 Harnesses...... 116-117 Headband Magnifier...... 91 Tubing & Connectors...... 126-127 K-LED Illumination System...... 91 Inspira Ventilators...... 186 Leather Padded Headband...... 91 Instant Ice Skin Refrigerant...... 53 Stand Magnifiers...... 92-93 Instrument Sterilizer...... 49 SuperVu Surgical Magnication Loupes...... 90-91 Hot Bead Sterilizer...... 49 Masks, See Anesthetic Masks Instrument Trays...... 50-51 Matrices...... 249-250 Instrument Wraps...... 52 Brain...... 249 Intensive Care Units, Small Animal...... 86-87 Heart, Tumor, Spinal Cord Matrices...... 250 Intubation Equipment...... 192-196 Metabolic Cages...... 134-138 Endotracheal Tube Adapter...... 192 Diuresis Cage for Mice...... 135 Endotracheal Tubes for Small Animals...... 194 Metabolic Cage for Mice...... 135-136 Fiber Optic Laryngoscopes...... 195 Mouse Metabolic Chamber Rack...... 136 Intubation Adapters...... 193 Refrigerated Collection Rack...... 138 Intubation Platform...... 196 Rodent...... 134-136 Small Animal Intubation Kits...... 194 Vertical Multiple Cage Rack...... 138 Tracheal and Intubation Cannulae...... 193 MicroVent Ventilator...... 187 Invasive Blood Pressure...... 205, 209-216 MidiVent Ventilator...... 188 Advisor Vital Signs Monitor...... 205 MIKRO-Tip Catheters...... 214 APT 300 Transducers...... 210 Millar Catheters...... 214-216 DTXPlus Sterile Disposable Transducer...... 212 MiniVent Ventilator...... 188 Millar MIKRO-Tip Catheters...... 214-216 MouseOxPlus...... 202 Millar Pressure Transducer Accessories...... 216 Millar SPR Series of Catheters & TC 510 Control Unit...... 216 Millar Ultra Miniature Catheters...... 214-216 P75 Venous Pressure Transducer...... 213 Research Grade Pressure Transducer...... 209 Sterile Single Use Pressure Sensor...... 211 TRA 021 Transducer - Panlab...... 211 ISO510A Transducer Amplifier...... 218 N Nebulizers...... 191 Aerosol...... 191 Ultrasonic Aerosol...... 191 Needle Holders...... 35-38

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 265 INDEX

PRODUCT PAGE PRODUCT PAGE

Needles...... 142-148, 153 Pressure, Respiratory Blunt with Aluminum Hub...... 146 Calibrators...... 219 Huber Point...... 153 Capnograph Flow Pressure Sensor for Mice or Rats...... 206 Hypodermic with Aluminum Hub...... 147 HSE-HA Limiter & Monitor, Mice or Rats...... 189 Hypodermic with Polypropylene Hub...... 147 Inspira...... 186 Micro Injection...... 148 Probes...... 45 Non-Coring Needle with Micro-Mate Hub...... 142 Pulse Oximetry...... 202-205 PortHold Non-Coring Needle Sets...... 153 Advisor Vital Signs Monitor...... 205 Reusable Fine Gauge...... 144 MouseOxPlus...... 202 Reusable Huber Point...... 145 MouseOxPlus Accessories...... 203 Reusable Hypodermic...... 143 MouseOxPlus Modules...... 203 Reusable Probe Point...... 144 MouseOxPlus Sensors...... 203 Septum...... 153 V1030 Hand Held Pulse Oximeter...... 204 Skin Tunneling...... 148 V3304 Pulse Oximeter...... 204 SOFTEE Right Angle Huber...... 153 Pump 11 Elite Nanomite...... 251 Ultra Fine Injection...... 148 Pyrogen Tester...... 72 Neuroscience...... 231-252 Non-Invasive Blood Pressure...... 220-223 NIBP MC4000 Multi-Channel...... 223 NIBP System from Panlab...... 220-221 NIBP System SC1000...... 222 R Nose Cones/Anesthetic Masks...... 173 Regulators, Hoses and Flowmeters...... 165-166, 168, 170 Canine Ventilation/Anesthesia Masks...... 173 Dual E-Tank Stabilizer...... 165 Cat Ventilation/Anesthesia Masks...... 173 Flowmeter Bench Stand...... 166 Coax Breathing Apparatus...... 173 Flowmeter, Air 0.2-15 LPM, Long Series...... 168, 170 Masks, Fluovac...... 180 Flowmeter, Air 0.2-2 LPM Short Series...... 168

Mouse Anesthetic Mask...... 173 Flowmeter, CO2 0-12 LPM, Long Series...... 166, 168

Rat, Guinea Pig and Bird Anesthetic Mask...... 173 Flowmeter, N2O 0.1-12 LPM, Long Series...... 166, 168

Flowmeter, N2O 0.2-2 LPM, Short Series...... 168

Flowmeter, O2 0.2-15 LPM, Long Series...... 166, 168, 170

Flowmeter, O2 0.2-2 LPM, Short Series...... 166, 168

Flowmeter, O2 0.4-4 LPM, Short Series...... 166 Flowmeter, O 0-10 LPM, Long Series...... 166, 170 O 2 Flowmeter, O2 0-15 LPM...... 165

Operating Tables...... 60-68 Flowmeter, O2 0-3 LPM...... 165

Frog Board...... 62 Flowmeter, O2 0-5 LPM...... 165

Heated...... 64-65 Flowmeter, Twin O2 and Air...... 170

Large Animal Operating Table...... 68-69 Flowmeter, Twin O2 and N2O...... 170

Mice and Rodents...... 60-61 Hose Barb, DISS Female N2O...... 165 Mini-OP Table...... 62 Hose, Air Piped to Flowmeter...... 166 Plastic Operating Boards...... 65 Hose, Medical Grade Air...... 166

Plastic Thoracic Positioners...... 68 Hose, N2O...... 166

Small Animal...... 63 Hose, N2O Piped to Flowmeter...... 166

Stainless Steel Thoracic Positioners...... 68 Hose, O2...... 166

Surgical Retractor Systems...... 66-67 Hose, O2 Piped to Flowmeter...... 166

Organ Cannulation ...... 55 Hose, O2 with DISS Fittings to Flowmeter...... 166

Aortic Cannulae to IH-5 System...... 55 Hoses O2...... 165

Aortic Cannulae to IH-SR System...... 55 Regulator Manifold, O2 for Dual E-tanks...... 165 Ball Joint Holder and Cannulating System Regulator, Air Pin-Index...... 166 for Pulmonary Artery...... 55 Regulator, Air Threaded...... 166

Cannulae for Isolated Liver or Kidney Perfusion...... 55 Regulator, CO2 Pin-Index...... 166

P75 Venous Pressure Transducer...... 213, 228 Regulator, CO2 Threaded...... 166

Regulator, N2O Pin-Index...... 166

Regulator, N2O Threaded...... 166

Regulator, O2 for E-Cylinder...... 165

Regulator, O2 for E-Cylinder with 0-15 LPM Flowmeter...... 165 Regulator, O for H-Cylinder...... 165 P 2 Regulator, O2 for H-Cylinder with 0-15 LPM Flowmeter...... 165

Physiological Monitoring Systems...... 224-230 Regulator, O2 for H-Cylinder with 0-3 LPM Flowmeter...... 165

Blood Flow & Pressure...... 225-228 Regulator, O2 Pin-Index Bull Nose...... 166

ECG, 12-Lead Einthoven...... 226 Regulator, O2 Single E-Tanks, with Double Tank Holder...... 165

ECG, 6-Lead Einthoven...... 225 Regulator, O2 Threaded...... 166 ECG, Single Lead...... 225 Regulator, Tube Mounts for any F-Cylinder Regulator...... 166 Flow Probes...... 227 Respiratory Valves...... 182-183 PLUGSYS...... 217 One-Way Valves...... 182 Portex Catheters...... 139 Two-Way Valves...... 183

266 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com INDEX

PRODUCT PAGE PRODUCT PAGE

Restrainers...... 254-258 Stereotaxic Probe Holders...... 246 Box Type Holders...... 256 Cannula Holder...... 246 Broome Restainers...... 255 Extra Large Probe Holders...... 246 Plastic Restraint Bags...... 255 Large Probe Holders...... 246 Rabbit Restrainer...... 257-258 Microdialysis Holders...... 246 Rodent Heated/Unheated...... 254-257 Standard...... 246 Rodent Injection Cone...... 255 Stereotaxic Scavenging & Warming, StereoDraft...... 245 Rodent Restainers, Universal ...... 256 Stereotaxic Upgrades & Conversions...... 240 Rodent Restraint Cones...... 255 Sterilizer, Glass Bead...... 49 Single Tube Holder with Access Holes...... 256 Sterilizing Trays...... 50-51 Small Animal Snuggle...... 257 Stopcocks...... 209, 211-213 Tube Type Holders...... 256 Surgical Drapes...... 52 Retractors...... 48 Surgical Equipment...... 57-98 Surgical Instruments...... 1-56 Surgical Kits...... 2-6 Deluxe Major Surgical Kit...... 6 S Minor Surgical Kit...... 6 Mouse Isolated Heart Surgical Kit...... 2 Scales and Balances...... 107-108 Mouse Isolated Organ Surgical Kit...... 3 Animal Weighing System...... 108 Mouse Surgical Kit...... 5 Battery Operated Portable Scale...... 107 Rat Surgical Kit...... 5 Triple-Beam Balance...... 107 Rat/Guinea Pig Isolated Heart Surgical Kit...... 2 Scalpel Blades...... 10-11 Rat/Guinea Pig Isolated Organ Surgical Kit...... 3 Scalpels & Scalpel Handles...... 8, 10-11 Rodent Microdialysis Surgical Kit...... 4 Scavenging & Evacuation...... 177-184 Rodent Microsurgical Kit...... 4 AES Gas Evacuation System...... 178 Surgical Lights...... 94-98 Down Draft Tables...... 177 APEX Major Surgical Lights...... 98 F/AIR Canister...... 178 Cool Spot II...... 97 Fluosorber Canisters...... 179 Gleamer Exam Lights...... 94 Fluovac System...... 179-181 Outpatient II...... 96 Lab Animal Evacuation system...... 178 Outpatient II/CoolSpot II Combination Lights...... 98 Scavenger Interface Valve for Active Systems...... 178 Super Exam 50...... 95 Scissors...... 12-20 Super Exam 50 LED...... 95 Bandage...... 20 Surgical Preparation...... 99-108 Eye...... 15-16 Surgical Towels...... 52 Operating...... 17-20 Suture Needles...... 43 Spring...... 12-14 Sutures & Needles...... 39-43 Universal Clothing ...... 20 Swivel Mounts...... 120-121 Skin Tunneling Needles...... 148 Counter-Balanced Lever Arms...... 120 Small Animal Recovery Chamber...... 89 Fixed for Tecniplast Metabolic Cages...... 121 Sponges...... 53 Mouse Micro-Isolator Cage Mount...... 121 Sponges, Absorbable ...... 53 Single Access Lever Arms...... 120 Sponges, Dissecting ...... 53 Swivel Bracket...... 121 Sponges, Spear-Shaped ...... 53 Swivels...... 112-115 Stereotaxic Drill...... 247-248 Disposable Plastic Swivels...... 114 Bone Micro-Drill...... 247 Multi-Channel Swivels...... 115 Ideal Micro-Drill...... 248 Stainless Steel Swivels...... 112-113 Stereotaxic Instruments...... 232-239, 241 Universal Swivel-to-Tether Clamp...... 115 Digital...... 238 Syringe Pumps...... 251 Just for Mice...... 237 Just for Mouse...... 236 Lab Standard...... 234 Large Animal...... 241 Motorized...... 239 New Standard...... 233 Rotating Elliptical for Rats...... 235 Ultra-Precise...... 232 T Stereotaxic Masks & Adaptors...... 242-245 Cat/Monkey Adaptor...... 243 Dog/Monkey Adaptor...... 243 T/Flex Plus Animal Handling Gloves...... 261 Gas Anesthesia Mask Adaptors...... 245 TAPi...... 218 Gas Anesthesia Platforms for Mice...... 245 Tattoo Pigment...... 106 Guinea Pig Adaptor...... 243 Tattoo Sets...... 106 Lab Standard Ear Bars...... 244 TC 510 Control Unit...... 216 Mouse Adaptor...... 242 TCAT-2 Temperature Controller...... 75-76 Mouse and Neonatal Rat Adaptor...... 242 Rat Adaptor...... 242 Small Bird Adaptor...... 244 Spinal Adaptor...... 244

To order call 1-508-893-8999 email [email protected] web www.harvardapparatus.com 267 INDEX

PRODUCT PAGE PRODUCT PAGE

Temperature Control Products...... 70-89 Vaporizer Accessories...... 171 12 Channel Digital Thermometers...... 71 Anti-Spill Device Isoflurane...... 171 Fluid Warming Cabinet...... 89 Anti-Spill Device Sevoflurane...... 171 Heat Lamp ...... 76 Endcap, Female...... 168, 171 Heat Therapy Pumps ...... 70 Endcap, Male...... 168, 171 Heating Plate for TCAT-2...... 76 Inlet Tube Mount...... 168 InfraRed Thermometer for Tails...... 85 Key-Fill Adapter Isoflurane...... 171 Intensive Care Units, Small Animal...... 86-87 Key-Fill Adapter Isoflurane Harvard Apparatus...... 171 Non-Contact InfraRed Thermometer...... 82 Key-Fill Adapter Sevoflurane...... 171 Portable Digital Thermometer...... 76 Key-Fill Adapter Sevoflurane Harvard Apparatus...... 171 Portable Thermocouple Thermometer...... 73 Outlet Tube Mount...... 168 Precision Thermistor Thermometer...... 82 Vaporizers...... 171 Small Animal Recovery Chamber...... 89 Vaporizers, Isoflurane...... 171 TCAT-2 Temperature Controller...... 75-76 Funnel-Fill, Classic T3...... 171 Temperature Therapy Pads...... 70 Funnel-Fill, Select-a-Tec ...... 171 Thermal Barrier...... 88 Key-Fill, Classic T3...... 171 Thermocouple Monitoring Thermometer...... 74 Key-Fill, Select-a-Tec ...... 171 Thermocouple Probes...... 77-81 Vaporizers, Sevoflurane...... 171 Vetcare Heated Chamber System...... 88 Funnel-Fill, Classic T3...... 171 Warm Air Chamber...... 87 Funnel-Fill, Select-a-Tec...... 171 YSI 400 Series Thermistor Probes...... 83-84 Key-Fill, Classic T3...... 171 Temperature Therapy Pads...... 70 Key-Fill, Select-a-Tec...... 171 Tethers...... 116-119 Vascular Access Ports...... 150-152 Glass Ionomer Cement...... 119 Huber Needles...... 153 Magnetic Head Block Tether...... 119 Intermediate...... 151 Vascular Access Buttons...... 118 Large...... 152 Vascular Access Harnesses ...... 116-117 Miniature Tubing Injection Port...... 153 Thermal Barrier...... 88 PortHold...... 152 Thermistor Temperature Probes...... 83-84 PortHold Non-Coring Needle Sets...... 153 Thermocouple Temperature Probes...... 77-81 Rodent...... 150 Thermometers...... 71, 73-85 Septum Needles...... 153 12 Channel Digital...... 71 Small...... 151 InfraRed for Tails...... 85 SOFTEE Right Angle Huber Needles...... 153 Non-Contact InfraRed...... 82 Vascular Occluders...... 148 Portable Digital...... 76 Ventilator Accessories...... 189, 192 Portable Thermocouple...... 73 Anesthesia Connection Kits...... 192 Precision Thermistor...... 82 Anesthesia Ventilation Adaption Kit...... 192 Thermocouple Monitoring...... 74 Pressure Limiter & Monitor...... 189 Thermocouple Probes...... 77-81 Ventilators...... 185-196 YSI 400 Series Thermistor Probes...... 83-84 613 Large Animal Ventilator...... 190 Thoracic Positioners...... 68 683 Small Animal Ventilator...... 187 Towels, Surgical...... 52 687 Mouse Ventilator...... 187 TRA 021 Transducer - Panlab...... 211, 228 Inspira Ventilators...... 186 Tracheal and Intubation Cannulae...... 193 MicroVent Ventitlator...... 187 Tubing...... 175, 184 MidiVent Ventilator...... 188 Tubing & Connectors, Infusion...... 123, 126-127 MiniVent Ventilator...... 188 CO-EX External Infusion Tubing...... 123 Vetcare Heated Chamber System...... 88 Luer Stubs...... 126 Vital Signs...... 197-230 Polyurethane Intravascular Tubing...... 127 Stainless Steel Tubing Connectors...... 127 Y Connectors (3-Way Connector)...... 126 Tweezers...... 21 W Warm Air Chamber...... 87 Wax, Bone...... 53 V Wound Closure Systems...... 44 Autoclip Wound Clip System...... 44 V1030 Hand Held Pulse Oximeter...... 204 Reflex Skin Closure System...... 44 V3304 Pulse Oximeter...... 204

V3395 Temperature, SpO2 & Respiration Monitor...... 207 V8401 Capnocheck...... 207 V9004 Series Intelligent Capnograph...... 208 Valves, See Respiratory Valves

268 To order call 1-508-893-8999 [email protected] web www.harvardapparatus.com Harvard Apparatus Worldwide

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Harvard Apparatus Harvard Apparatus - Panlab 84 October Hill Road C/Energia, 112 Holliston, Massachusetts 01746, USA 08940 Cornellà, Barcelona, Spain Tel: +1 508 893 8999 Tel: +34 934 750 697 (International Sales) Toll Free: +1 800 272 2775 (US Only) +34 934 190 709 (Sales in Spain) Fax: +1 508 429 5732 Fax: +34 934 750 699 [email protected] [email protected] www.panlab.com www.harvardapparatus.com

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Harvard Apparatus Canada Harvard Apparatus - CMA 6010 Vanden Abeele Box 7048 Saint-Laurent, Quebec, H4S 1R9, Canada SE-164 07 Kista, Sweden Tel: +1 514 335 0792 Tel: +46 8 470 10 00 Toll Free: +1 800 361 1905 (Canada only) Fax: +46 8 470 10 50 Fax: +1 514 335 3482 [email protected] www.microdialysis.com [email protected] www.harvardapparatus.ca United Kingdom

France Harvard Apparatus, Ltd. Fircroft Way, Edenbridge Harvard Apparatus, S.A.R.L. Kent TN8 6HE, United Kingdom 6 Avenue des Andes Tel: +44 1732 864001 Miniparc – Bat. 8 Fax: 91952 Les Ulis Cedex, France +44 1732 863356 [email protected] Tel: +33 1 64 46 00 85 www.harvardapparatus.co.uk Fax: +33 1 64 46 94 38 [email protected] www.harvardapparatus.fr

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Harvard Apparatus solutions are available Harvard Apparatus from a wide network of distribution Hugo-Sachs Elektronik partners. Please contact us or visit Gruenstrasse 1 www.harvardapparatus.com to find a D-79232 March-Hugstetten, Germany distributor near you. Tel: +49 0 7665 9200-0 Note: Products in this catalog are for Research Use Only. They Fax: +49 0 7665 9200-90 are not for use on humans unless proper investigational device [email protected] regulations have been followed. www.harvardapparatus.de Harvard is a registered trademark of Harvard University. The marks Harvard Apparatus and Harvard Bioscience are being used pursuant to a license agreement between Harvard University and Harvard Bioscience, Inc. SURGICAL SOLUTIONS FOR RESEARCH

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