Less Ultra Violet FOR YOUR SKIN with SunSense™, The UK’s best LUVed Prescription .¹

LUV THE WHOLE RANGE, AVAILABLE WITHOUT PRESCRIPTION, AT SUNSENSE.CO.UK LUV YOUR SKIN

Help patients give their skin a little LUV and reduce their risk of damage with SunSense.™

For people in high-risk groups, spending time in SunSense™ The UK’s Best LUVed Prescription Sunscreen.¹ the sun can be more of a pain than a pleasure. SunSense™ SPF 50+, prescribed by more dermatology nurses in the Certain people are more susceptible to developing UK than any other brand¹, helps protect people by exposing the skin to Less Ultra Violet radiation, which can significantly reduce problems such as , pigmentation, premature their risk of skin cancer and other harmful effects of the sun54. ageing, wrinkles and skin cancers.² That’s why it’s SunSense™ helps protect even the most sensitive skin against particularly important they apply a sunscreen and UVA and UVB radiation, making it perfect for the whole family. use other sun protective measures.

First LUVed in Australia SunSense™ is the highest SPF (SPF 50/50+)3 available in Australia and is designed for all ages and skin types. Formulated to meet the Australian Standard53, the most stringent in the world – it contains high-quality ingredients that help protect against UVA and UVB radiation and is dermatologically tested, making it suitable for sensitive skin.

WHO IS IN A HIGH-RISK WHY WE ARE THE UK’S BEST GROUP FOR SUN DAMAGE? LUVED PRESCRIPTION SUNSCREEN?¹

Skin type is one of the main factors that determine the risk of are often prescribed to people with skin sunburn.4 From light skin (highest risk) to dark skin (lowest risk), photosensitivity, cancer or genetic conditions. there are six skin types that correlate with a person’s In the UK, British dermatology nurses prescribe more susceptibility to sunburn.4 SunSense™ sunscreen products than any other brand due to its high efficacy and quality ‘skin feel’.1,8

Factors that pose higher risks for skin cancer include: Highest SPF3 available in Australia • Personal or family history of skin cancer.5,6 In Australia, the maximum SPF that can be claimed has been raised to 50+3. To be able to claim SPF 50+, a sunscreen • Exposure to the sun through work or play. must have a static SPF of at least 603. The new SunSense™ • A history of or sunbed use.5 formulations meet this sunscreen standard, providing more UVA and UVB protection from the sun’s harmful radiation. • Fair – or very fair – skin types, which burn easily.5,6 In Europe, sunscreens are allowed to lose up to 50% of their • Blonde or red hair.5 label SPF after exposure to water9. But in Australia, the label 3 • Light-coloured eyes.5 SPF must be retained when water resistance is claimed . For example, an SPF 50+ sunscreen that claims 4 hours’ water • A large number of moles.5,6 resistance must still be SPF 50+ after 4 of hours exposure to water. • Patients with auto-immune diseases such as Crohn’s Water-Resistance disease and ulcerative colitis. The spa pool testing method55 has been used to measure • People using immuno-suppressive drugs.6 water resistance of SunSense™ sunscreens. All SunSense™ 52 • Those with conditions such as eczema, dermatitis body sunscreens provide 4 hours of water resistance. and psoriasis. Broad Spectrum • Patients undergoing, or recovering from, radiotherapy.7 SunSense™ sunscreens are broad spectrum (protecting against UVA and UVB radiation). They have been tested according to the Australian/New Zealand Standard, meaning that they deliver UVA protection of at least one third of the labelled SPF.56 PRESCRIBING SUNSENSE™

Sunsense™ Ultra can be prescribed for skin protection against radiation in abnormal cutaneous photosensitivity resulting from genetic disorders WHAT DOES SPF MEAN? or photodermatoses, including vitiligo and those SPF (Sun Protection Factor) is a measure of protection resulting from radiotherapy; chronic or recurrent of the skin from burning (erythemal UV radiation). SPF herpes simplex labialis. Preparations with SPF less is calculated by measuring the amount of time required than 30 should not normally be prescribed.57 to produce the first sign of reddening (erythema) on unprotected skin, and comparing it to the time it takes Key conditions to prescribe SunSenseTM to produce the first sign of reddening (erythema) on skin protected with sunscreen.4 • Melanoma • Radiotherapy • Vitiligo • Polymorphic Time taken • Lupus light eruption Time taken to burn to burn WITH WITHOUT sunscreen sunscreen

REDUCING UV RADIATION MYTH BUSTING AN SPF 50+ SUNSCREEN CAN REDUCE EDUCATING PATIENTS ON THE ERYTHEMAL UV RADIATION REACHING IMPORTANCE OF GIVING THEIR THE SKIN BY APPROXIMATELY 50% SKIN A LITTLE LUV. WHEN COMPARED TO AN SPF 30+ SUNSCREEN IF USED CORRECTLY.10 Malignant melanoma rates have increased rapidly in 11 Developed to suit individual needs, the SunSense™ range England in the last 35 years. DID YOU KNOW... of sunscreen products has the highest SPF available, In fact, UK deaths from skin and offers both UVA and UVB protection.3 cancer are now overtaking Australia12 – but many people Over 25 years of research and development ensures 70% still overlook the risks in favour SunSense™ sunscreens offer a high level of protection. of a sun tanned appearance. MELANOMA All SunSense™ sunscreens are specifically formulated, Malignant melanoma is the May be preventable high-quality products that provide specialised choices by regular sunscreen 5th most common cancer in 13 for all ages and skin types, including sensitive skin use in adults. the UK (2011), accounting for and children’s skin. 4% of all new cases.50 Sun exposure is the main cause of UV damage. About 25% of lifetime UV sun exposure can occur by the age Cancer Research UK conducted a study in 2014 highlighting of 20.10 When recommending a sunscreen, remember that there were 15,419 new cases of melanoma in the UK that everyone’s skin is different and no single product of which 5.3% of the cases resulted in deaths.51 We want will suit everybody. to educate patients that is not good for their health. In order to help to prevent skin cancer and educate consumers on the importance of Less Ultra Violet, we have created our FREE SunSense™ LUV your skin support packs. Request your pack from your TBM.

Each SunSense™ Educational Pack includes leaflets, posters and balloons, to make your event a success. SPREADING CREAM UP THE LUV HOW TO APPLY SUNSCREEN The importance of application and reapplication. In many cases, people do not apply enough sunscreen to achieve the label SPF (2mg/cm2).58 Sunscreens require Apply 20 minutes Over 1/2 teaspoon Over 1 teaspoon on legs, reapplication to maintain their optimum before exposure. on arms, face/neck. front and back of body. level of protection. It’s important to educate patients on the amount and frequency of application. The guide opposite is based on recommendations for an average sized adult. Apply every 2 hours, Use sunscreen generously, A whole range of especially after swimming, and reapply frequently. SunSenseTM products exercising, sweating and to LUV. towelling dry. Waterproof sunscreen REMEMBER! does not exist.

THE SUNSENSE™ PRODUCT RANGE

FAMILY LUV LUV YOUR SKIN – DAILY LUV SPORT LUV SENSITIVE SKIN

Our sunscreens suitable for SunSense™ Daily Face SPF 50+ Ideal for sports enthusiasts SunSense™ Anti-ageing Face the family include SunSense™ is ideal for everyday use to and active people, SunSense™ SPF 50+ and SunSense™ Ultra SPF 50+, a light, smooth, help protect against the signs Sport Gel SPF 50+ and Anti-ageing Face Matte SPF 50+ easy-to-apply lotion; and of premature ageing from SunSense™ Sport Mist SPF both contain lactic acid to SunSense™ Kids SPF 50+, a sun exposure. 50+ are light, alcohol-based help visibly reduce fine lines specially formulated sunscreen sunscreens that provide and wrinkles while they for the delicate skin of children broad spectrum protection. protect you from the sun’s aged 6 months and above. • SPF 50+, UVA and UVB The SunSense™ Sport range is harmful radiation. broad spectrum protection. suitable for • Oil-free base – ideal acne-prone, oily skin or hairy • SPF 50+, UVA and UVB broad for combination skin. areas of the body. • SPF 50+, UVA and UVB broad spectrum protection. spectrum protection. • Contains Vitamin E and • 4 hours of water-resistance. niacinamide to help • Oil-free base – ideal for • Feels cool and dry. • Available in a range of sizes, improve skin elasticity. combination skin. including a handy roll-on. • 4 hours of water-resistance. • Contains Vitamin E and Complementing the range is • Contains Vitamin E and niacinamide to help ™ SunSense Lip Balm SPF 50+. niacinamide to help improve improve skin elasticity. Available in a 15g glide-on skin elasticity. applicator tube, it soothes, • Available in 125ml bottle moisturises and helps protect (gel) and 200ml spray (mist). lips in all seasons. SUNSENSE™ IS DEVELOPED TO SUIT INDIVIDUAL NEEDS, SKIN TYPES AND AGES.

Nine reasons why we are the UK's No.1 SunSense™ sunscreens are ideal for people prescription sunscreen. with sensitive skin.

In cases of solar urticaria, the most common photosensitivity disorder, studies have found that 60% of patients tested were sensitive only to visible light and not to UV radiation.42 Over 25 years of Formulated using Dermatologically Australian research high-quality tested. While most sunscreens offer very little protection from and development. ingredients. visible light, SunSense™ Sensitive and SunSense™ Sensitive Matte provide significant levels of protection against visible light and are therefore beneficial to people 50+ with photosensitivity disorders including solar urticaria, chronic actinic dermatitis and polymorphic light eruptions.43 Protection from UVA radiation is of primary Highest labelled Physical blockers and MI-free. SPF available3 chemical absorbers importance to those patients taking medication which in Australia. for highest levels predisposes them to drug induced photosensitivity.44 of protection. In most SunSense™ sunscreens, UV absorbers are combined with . This helps provide greater protection against UV radiation. In many cases, it also works synergistically with UV absorbers to give higher SPF values. Free from All products reformulated Broad spectrum, to paraaminobenzonic to meet stringent help protect the skin acid derivatives Australian regulations. from UVA and UVB. and lanolin.

VITAMIN D AND SUNSENSE™ SUNSCREENS SPF 50+ SUNSCREENS FOR CHILDREN While sunscreen has been suggested to reduce vitamin • A baby’s skin can burn easily because it’s thin and far D synthesis, several studies have failed to show any more sensitive.48 evidence that regular use of sunscreen results in vitamin • Children are also outside in the sun more often than D deficiency.30 And, whilst the sun can increase your risk adults. About 25% of a person’s lifetime UV exposure takes of developing skin cancer, small doses outside high UV place by the age of 20.49 index hours can help the body produce vitamin D to aid in the development and maintenance of healthy teeth • It is recommended for adults to apply sunscreen to and bones. Patients may worry that SunSense™ sunscreens their children’s exposed skin at least 20 minutes before will interfere with vitamin D production. sun exposure; minimise their time in the sun, especially Studies in high-risk groups have found that sunscreen at midday (when the UV index is at use does not cause vitamin D deficiency or increase the its highest); seek shade; and wear risk of osteoporosis.45,46 Normal vitamin D levels can be protective clothing, a hat and eyewear. maintained from diet and supplements.47 Individuals who • SunSense™ Kids has been specially are concerned about their vitamin D level should consult developed for the delicate skin their doctor to arrange for testing. Based on the test result, of children aged 6 months and the doctor may recommend vitamin D supplements. above, with SunSense™ Sensitive recommended for those with extremely sensitive skin, and for babies.

Helps maintain healthy Won’t cause Vitamin D Maintain normal teeth and bones.3 deficiency or Vitamin D levels from osteoporosis.4,5 diet and supplements.7 SUNSENSE™ INGREDIENTS TABLE

FAMILY FACE SENSITIVE SPORT SunSense™ SunSense™ SunSense™ SunSense™ Anti- SunSense™ SunSense™ SunSense™

Type Ultra SPF 50+ Kids SPF 50+ Daily Face SPF 50+ ageing Face SPF 50+ Lip Balm SPF 50+ Sensitive SPF 50+ Sport Gel &

Product Product (Also available in (Also available in SunSense™ matte finish) matte finish) Sport Mist SPF 50+

Suitable for the Children aged six Face and neck, Face and neck, to Helps protect Hypersensitivity to Suitable for all skin Use family. Provides months and above. combination help reduce and and moisturise common sunscreen types, including very high protection. oily skin. prevent the signs lips in all seasons. ingredients and acne-prone skin. of premature ageing suitable for infants. due to sun exposure. Paediatrician tested. Recommended

50ml roll-on 50ml roll-on 75g tube 100ml bottle 15g glide-on applicator 100g tube 125ml bottle (gel) Size 125ml bottle 125ml bottle 200ml bottle 200ml spray (mist) 500ml pump

100+ 70+ 75+ 70+ (original) 75+ 70+ 65+ SPF

Static 75+ (matte) (actual)

50+ 50+ 50+ 50+ 50+ 50+ 50+ SPF Label

4 Hours 4 Hours N/A N/A N/A 4 Hours 4 Hours Resist Water Water

UVA, UVB and UVA, UVB and UVA, UVB and UVA, UVB. UVA, UVB and UVA, UVB and UVA, UVB. Ray screens infrared screens infrared screens infrared screens infrared screens infrared and visible light. and visible light. and visible light. and visible light. and visible light. Protectors

Moisturising. Moisturising. Oil-free. Oil-free, moisturising. Protective Low irritant. Light alcohol-

Base and soothing. based gel.

Barely visible. Barely visible. Matte, invisible. Barely visible. Slight sheen. Slight sheen. Clear and dry. Coverage

• Titanium Dioxide • Ethylhexyl • -3 • Ethylhexyl • Ethylhexyl • Titanium Dioxide • Ethylhexyl Nano (Active) Salicylate • Diethylamino Methoxycinnamate Methoxycinnamate Methoxycinnamate

UV Filters • Diethlamino • Titanium Dioxide Hydroxybenzoyl • Bis-ethylhexylo- • Butyl-methoxy- • Hydroxybenzoyl • Diethylamino Hexyl Benzoate xyphenol dibenzoylmethane • Hexyl Benzoate Hydroxybenzoyl • Titanium Dioxide Methoxyphenyl • Diethylamino • Butyl-methoxy- • Octocrylene Hexyl Benzoate (Nano) Triazine • Hydroxybenzoyl dibenzoylmethane • • Bis-ethylhexylo- • Bis-ethylhexylo- • Diethylamino • Hexyl Benzoate • Diethylamino xyphenol xyphenol Hydroxybenzoyl Bis-ethylhexylo- Hydroxybenzoyl Methoxyphenyl Nethoxyphenyl Hexyl Benzoate xyphenol Hexyl Benzoate Triazine Triazine Methoxyphenyl • Ethylhexyl Triazine Methoxycinnamate • Benzophenone-3, Titanium Dioxide (Nano)

• Phenoxyethanol • Sodium • Sodium • Diazolidinyl • Preservative-free • Sodium • Preservative-free • Methyl Methylparaben Methylparaben Methylparaben Hydroxybenozoate • Sodium • Sodium • Sodium Propylparaben Propylparaben Propylparaben

Preservatives • Propyl Hydroxybenzoate • Phenoxyethanol • Dichlorobenzyl • Diazolidinyl Urea Alcohol • Phenoxyethanol

• Vitamin B3 • Vitamin B3 • Vitamin B3 • Vitamin B3 • Tocopherol • Vitamin B3 • Vitamin B3 (Niacinamide) • Tocopherol • Tocopherol (Vitamin E) • Tocopherol Special (Vitamin E) (Vitamin E) • Cacao (Cocoa) (Vitamin E) Ingredients • Lactic Acid (AHA) • Seed Butter GLOSSARY

UV Filters Benzophenone-3 Octocrylene All SunSense™ sunscreens are specifically (Also known as ) Octocrylene has an excellent safety formulated, high quality products and Absorbs UV radiation in the UVB and profile with low irritation, phototoxicity, are ideal to use every day to help protect lower wavelength region of UVA.26 and photoallergic potential.61 Octocrylene against sunburn, skin pigmentation, Benzophenone-3 performs an may be used in combination with other UV premature ageing, wrinkles and skin important function as a bridge absorbers to achieve higher SPF formulas cancer.2 Over 25 years of Australian between the absorbance of UVB filters and to add stability.60 research and development ensures and the UVA region filtered by butyl SunSense™ sunscreens contain UV filters methoxydibenzolymethane. It can SPECIAL INGREDIENTS that are able to filter UVA and UVB. help protect against sunburn and provide some protection against Vitamin B3 (Niacinamide) Titanium Dioxide photosensitivity reactions associated Products across the SunSense™ sunscreen 27 A physical blocker which reflects, with UVA light. Toxicity studies have range* contain vitamin B3, used at the absorbs and scatters ultraviolet radiation, found benzophenone-3 to be non- optimum percentage to deliver its key 26 visible light and infrared radiation.16 sensitising and non-phototoxic. benefits.31 It assists in maintaining normal Titanium dioxide has a high refractive skin barrier function, locks in moisture Methylene Bis-benzotriazolyl index, which gives it excellent light and increases elasticity.32 It also helps 17 Tetramethylbutylphenol scattering properties. Titanium dioxide improve the appearance of skin tone also has the benefit of not producing This unique UV filter is able to absorb, and texture, and helps to reduce skin contact sensitisation, phototoxicity scatter and reflect UV radiation,28 thus hyperpigmentation.33 or photoallergy.18 combining the advantages of both physical blockers and UV absorbers. Methylene Vitamin E Ethylhexyl Methoxycinnamate bis-benzotriazolyl tetramethylbutylphenol Tocopherols concentrate – mixed (low (Also known as ) is non-irritating to the skin, alpha), commonly known as vitamin E, is a non-sensitising, non-phototoxic One of the most widely used UVB fat-soluble vitamin. Vitamin E is recognised and non-photosensitising.28 absorbers due to its excellent safety as an antioxidant that can help protect 34 profile and high extinction against the formation of lipid peroxides. coefficient (efficiency).19 Topical vitamin E has been found to help (Also known as Octyl Triazone) protect from UV-induced erythema,35,36 wrinkling 37,38 and roughness.39 It can also Butyl Methoxydibenzoylmethane A UV filter that absorbs specifically in the help improve the appearance of age UVB region, with an absorption maximum A UVA filter. The addition of butyl spots, make fine lines and wrinkles of 314nm.29 With an extinction coefficient methoxydibenzoylmethane to the look smoother and help improve 20 of 1,550 at 314nm, low levels of this FDA list of Category one sunscreens skin elasticity.40 established its worldwide approval absorber can be used effectively in sunscreens.29 for use in sunscreens. It offers some Preservatives protection against drug-related or other SunSense™ sunscreen products contain photosensitivity reactions associated Bemotrizinol parabens to help protect them from with UVA light.21 Bemotrizinol (INCI: bis- microbial contamination. Parabens ethylhexyloxyphenol methoxyphenyl are widely used preservatives and are Bis-Ethylhexyloxyphenol triazine) has an added advantage generally well-tolerated, having broad Methoxyphenyl Triazine of being photostable so is often spectrum antimicrobial activity, and are (Also known as Bemotrizinol) formulated with less photostable relatively non-irritating, non-sensitising UV blockers such as Avobenzene 41 A combined UVB and UVA absorber and with low toxicity. (Butyl Methoxydibenzoylmethane). with absorption maxima at 310nm and 343nm.22 Toxicity and safety studies This combination of sunscreen actives Diethylamino Hydroxybenzoyl by the manufacturer have shown can be more stable and can help to slow Hexyl Benzoate bemotrizinol to be a non-sensitiser down degradation on exposure to light. A sunscreen agent used to absorb UVA 23 ™ and non-irritating to the skin. This combination is present in SunSense radiation, having an absorption maximum 59 Lip Balm. of 354nm.24,25 LUV TO SHOP FOR THE WHOLE RANGE

The complete range of SunSense™ products is available in the UK for your patients to purchase from the SunSense™ shop. Other stockists include local pharmacies, John Lewis, Waitrose, Ocado and Amazon.

Always read the label and use only as directed. Do not stay too long in the sun, even while using a sunscreen product. Remember to cover up, stay shady, drink lots and cream up. Reapplication is required every 2 hours; after swimming, sweating and towel-drying.

For samples or information, please contact Crawford Healthcare on 01565 654920 or email [email protected] For more educational materials please visit sunsense.co.uk

SUNSENSEUK @SUNSENSEUK @SUNSENSEUK

REFERENCES

1. Reference as IMS Pharmacy sales data November 2017. Data held on file. 22. Shaath NA (ed). The Encyclopedia of Ultaviolet Filters. Carol Stream IL: 40. Idson B. Vitamins in emolliency and moisturising preparations. NHS BSA prescription services, prescription cost analysis England, Allured Publishing Corporation 2007. P92-93. Bis-ethylhexyloxyphenol Cosmet Toiletries. 1976; 93(8):77-9. October 2016 data. methoxyphenyl triazine. 41. Soni MG, Carabin IG, Burdock GA. Safety assessment of esters of 2. Flament F, Bazin R, Laquieze, Rubert V, Simonpietri E, Piot B. Effect of the 23. National Industrial Chemicals Notification and Assessment Scheme p-hydroxybenzoic acid (parabens). Food Chem Toxicol 2005; 43 (7): sun on visible clinical signs of aging in Caucasian skin. Clin Cosmet Investig (NICNAS). Full Public Report. Tinosorb S. File no: LTD/1203. 18 August 2005. 985-1015. Dermatol 2013;6: 221-232. (Data held on file). 42. Uetsu N, Miyauchi-Hashimoto H, Okamoto H, Horio T. The clinical 3. In accordance to AS/NZS 2604:2012; Very High, SPF 50+, Broad Spectrum. 24. Vielhaber G, Grether-Beck S, Koch O, Johncock W, Krutmann J. Sunscreens and photobiological-characteristics of solar urticarial in 40 patients. with anabsorption maximum of >/= 360nm provide optimal protection Br J Dermatol 2000; 142:32-38. 4. Cancer Research UK. When do I need to protect myself? [Internet] against UVA1-induced expression of matrix metalloproteinase-1, [updated 2014 Feb]17; cited 2015 Apr 20]. Available from: http://sunsmart. 43. Hawk JLM. Cutaneous Photobiology in: Champion RH, Burton JL, Burns interleukin-1, and interleukin-6 in human dermal fibroblasts. Photoch org.uk/UV-the-sun-and-skincancer/when-do-i-need-to-protect-myself/ DA, BreathnachSM editors. Rook / Wilkinson / Ebling Textbook of Photobiol Sci 2006; 5:275-82. Dermatology, Volume 2, Sixth edition. Milan, Blackwell Science Ltd 1998. 5. Cancer Research UK. UV, the sun and skin cancer. [Internet] [updated 25. Shaath NA (ed). The Encyclopedia of Ultraviolet Filters. Carol Stream Chapter 25, Cutaneous Photobiology;p.973 – 993. 2014 Feb 17; cited 2015 Apr 20]. Available from: http://sunsmart.org.uk/ IL: Allured Published Corporation; 2007. p102-3. Diethylamino UV-the-sun-and-skin-cancer/ 44. Marks R. Skin cancer – childhood protection affords lifetime protection. hydroxybenzoyl hexyl benzoate. Med J Aust 1987:147(10): 475-6. 6. Sunscreen and Sun Safety Fact sheet. © British Association of 26. Shaath NA (ed). The Encyclopedia of Ultaviolet Filters. Carol Stream IL: Dermatologists 2009. 45. Norval M, Wulf HC. Does chronic sunscreen use reduce vitamin D Allured Publishing Corporation 2007. P74-75. Oxybenzone. production to insufficient levels? Br. J. Dermatol. 2009;161(4):732–6 7. Cancer Research UK. Radiotherapy and your skin. [Internet] 27. Martindale: The Complete Drug Reference 35th edition. London: [updated2015 May 2; cited 2015 May]. Available from: http://www. 46. MacKie RM. Vitamin D in treated melanoma patients on follow up. Pharmaceutical Press, 2007. Oxybenzone p1447. cancerresearchuk.org/about-cancer/cancers-in-general/treatment/ Br. J. Dermatol. 2010;162(3):697. radiotherapy/side-effects/general/radiotherapy-and-your-skin. 28. Ciba Speciality Chemicals Pty Ltd – Data Brochure: Ciba® TINOSORB M 47. Rice SA, Carpenter M, Vearncombe LM, Baird J, Healy E. Can healthy (M.TB.0001.e.01). (Data held on file). 8. Crawford Healthcare Ltd Research 2015 Data on file. adults maintain sufficient vitamin D levels without ultraviolet radiation? 29. Shaath NA (ed). The Encyclopedia of Ultaviolet Filters. Carol Stream IL: Implications for prevention of skin cancer. Br. J. Dermatol. 2010;163 9. COLIPA Recommendation No.16 – water resistance labelling. Allured Publishing Corporation 2007. P128-129. Ethylhexyl triazone. (Supple. 1):58–9. The European CosmeticToiletry & Perfumery Association. 2006. 30. Youl PH, Janda M and Kimlin M. Vitamin D and sun protection: 48. Seidenari S, Giusti G, Bertoni L, Magnoni C, Pellacani G. Thickness and 10. SPF 30+ is defined as SPF 31 and SPF 50+ is defined as 60.1 as per The impact of mixed public health messages in Australia. echogenicity of the skin in children as assessed by 20-MHz ultrasound. AS/NZS 2604:1998 & 2012 Int J Cancer 2009; 124: 1963-1970. Dermatology 2000; 201(3): 218–222. 11. http://www.britishskinfoundation.org.uk/SkinInformation/ 31. Matts PJ, Oblong JE, Bissett DL. A Review of the Range of Effects 49. Godar DE. UV Doses Worldwide. Photochem Photobiol. 2005; 81(4): SkinCancer.aspx of Niacinamide in Human Skin. IFSCC Magazine 2002; 5(4):285-9. 736 – 749. 12. https://melanoma.canceraustralia.gov.au/statistics 32. Grosick TL, Hollis V. Making sensitive skin less sensitive. J Am Acad 50. http://ww.cancerresearchuk.org/cancer-info/cancerstats/types/skin/ 13. Vallejo-Torres L, Morris S, Kinge JM, Poirier V, Verne J.l Measuring current Dermatol (poster). incidence/uk-skin-cancer-incidence-statistics and future cost of skin cancer in England. Journal of Public Health. 2014; 33. Bissett DL, Miyamoto K, Sun P et al. Topical niacinamide reduces 51. http://www.cancerresearchuk.org/health-professional/cancer-statistics/ 36(1): 140-148. doi:10.1093/pubmed/fdt032. yellowing, wrinkling, res blotchiness and hyperpigmented spots statistics-by-cancer-type/skin-cancer 14. Schneider J. The teaspoon rule of applying sunscreen. Arch Dermatol. in aging facial skin. Inter J Cosmetic Sci 2004; 26:231-38. 52. Tested in accordance to AS/NZS 2604:2012 Appendix B – Determination 2002; 138:838-839. 34. Niki E, Yamamoto Y, Komuro E, Sato K. Membrane damage due to of Water Resistance guidelines. 15. Möller H, Ansmann A, Wallat S. The effects of Vitamin E on the skin lipid oxidation. Am.J. Clin. Nutr. 1991;53:201S–205S. 53. IRI Pharmacy Sunscreen SPF 50-59, Dollars MAT to 05.11.2017. in topical applications. 35. Potapenko AY, Abieva GA, Pliquett F. Inhibition of erythema of the 54. https://www.nhs.uk/conditions/melanoma-skin-cancer/#preventing- 16. Lowe NJ. Physicians Guide to Sunscreens. Marcel Dekker, Inc, skin photosensitizes with 8-methoxypsoralene by -tocopherol. melanoma Internet (cited February 2018). New York. p.4. 1991. Bull Exp Biol Med 1980; 89:611-5. 55. http://dermatest.com.au/pdf/SPF%20ISO%20Protocol.pdf 17. MacLeod TM, Frain-Bell W. A study of physical light screening agents. 36. Dreher F, Denig N, Gabard B, Schwindt DA, Maibach HI. Effect of topical Brit J Derm;92: 149-156, 1975. antioxidants on UV-induced erythema formation when administered 56. Tested in accordance to AS/NZS 2604:2012 and ISO 24443:2012 guidelines. 18. Gonzalez E, Gonzalez S. Drug photosensitivity, iodopathic after exposure. Dermatology1999; 198:52-5. 57. https://bnf.nice.org.uk/treatment-summary/sunscreen.html photodermatoses,and sunscreens. J Am Acad Dermatol; 35(6): 37. Bissett DL, Chatterjee R, Hannon DP. Protective effect of a topically applied cited 12 Feb 2018. 871-885, 1996. anti-oxidant plus an anti-inflammatory agent against ultraviolet radiation- 58. Therapeutic Goods Administration (TGA): Australian Regulatory 19. Shaath NA, Griffi n PM, Andemicael GI, Agrapidis-Palompis LE. induced chronic skin damage in the hairless mouse. J Soc Cosmetic Guidelines for Sunscreens, Version 1.1, January 2016. Interpretation and evaluation: spectroscopic data of sunscreens. Chemists 1992; 43:85-92. 59. https://www.dermnetnz.org/topics/allergy-to-bemotrizinol/ In: Lowe NJ, Shaath NA, editors Sunscreens: Development, Evaluation 38. Bissett DL, Hillebrand GG, Hannon DP. The hairless mouse as a model and Regulatory Aspects. New York. Marcel Dekker, Inc, 1990. p.578. of skin photoaging: its use to evaluate photoprotective materials. 60. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482794/ 20. Food and Drug Administration (USA). Sunscreen Drug Products for Photodermatology 1989; 6:228-33. 61. Nash JF. Human safety and efficacy of ultraviolet filters and sunscreen Over-The-Counter Human Use; Final Monograph. May 21st, 1999. 39. Möller H, Ansmann A, Wallat S. The effects of Vitamin E on the skin in products Dermatol Clin. 2006; 24(1): 35-51. 21. Martindale: The Complete Drug Reference 35th edition. topical applications. Lecture presented at the DGF Vitamin E symposium London: Pharmaceutical Press, 2007. p1433. in Bochum 1989; March 4.

Distributed in the UK by Crawford Healthcare Ltd. www.crawfordhealthcare.com © Crawford Healthcare Ltd 2018. Always read the label and only use as directed. Do not stay too long in the sun, even while using a sunscreen product.