ACE2 blocking peptide (CDBP5006) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description The protein encoded by this gene belongs to the angiotensin-converting family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell- specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV- NL63. [provided by RefSeq, Jul 2008]

Immunogen 17 amino acids near the center of human ACE2.

Nature Synthetic

Expression System N/A

Species Reactivity Human, mouse

Conjugate Unconjugated

Applications Used as a blocking peptide in immunoblotting applications.

Procedure None

Format Liquid

Concentration 200 μg/mL

Size 0.05mg

Preservative None

Storage -20°C

ANTIGEN GENE INFORMATION

Gene Name ACE2 angiotensin I converting enzyme 2 [ Homo sapiens (human) ]

Official Symbol ACE2

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Synonyms ACE2; angiotensin I converting enzyme 2; ACEH; angiotensin-converting enzyme 2; peptidyl- dipeptidase A; metalloprotease MPROT15; ACE-related ; angiotensin- converting enzyme homolog; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

Entrez Gene ID 59272 mRNA Refseq NM_021804

Protein Refseq NP_068576

UniProt ID Q9BYF1

Pathway ACE Inhibitor Pathway; Metabolism of Angiotensinogen to Angiotensins; Metabolism of proteins; Peptide hormone metabolism; Protein and absorption; Renin-angiotensin system

Function carboxypeptidase activity; activity; glycoprotein binding; NOT metallopeptidase activity; peptide hormone binding; NOT peptidyl-dipeptidase activity; protein binding; virus receptor activity; virus receptor activity; zinc ion binding

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved