Author’s Accepted Manuscript

Irritability in ADHD: associations with depression liability

Olga Eyre, Kate Langley, Argyris Stringaris, Ellen Leibenluft, Stephan Collishaw, Anita Thapar

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PII: S0165-0327(16)31334-9 DOI: http://dx.doi.org/10.1016/j.jad.2017.03.050 Reference: JAD8849 To appear in: Journal of Affective Disorders Received date: 2 August 2016 Revised date: 26 September 2016 Accepted date: 24 March 2017 Cite this article as: Olga Eyre, Kate Langley, Argyris Stringaris, Ellen Leibenluft, Stephan Collishaw and Anita Thapar, Irritability in ADHD: associations with depression liability, Journal of Affective Disorders, http://dx.doi.org/10.1016/j.jad.2017.03.050 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Title: Irritability in ADHD: associations with depression liability

Authors: Olga Eyre1, Kate Langley1,2, Argyris Stringaris3, Ellen Leibenluft4, Stephan Collishaw1, Anita Thapar1.

Affiliations: 1MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, University, , UK. 2School of , , Wales, UK. 3Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK. 4Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.

Corresponding Author: Olga Eyre, MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Hadyn Ellis Building, Maindy Road, Cardiff University, CF24 4HQ, UK. Email: [email protected] Phone: (+44) 029 2068 8452

Abstract

Background: Irritability and the new DSM-5 diagnostic category of Disruptive Mood

Dysregulation Disorder (DMDD) have been conceptualised as related to mood disorder.

Irritability is common in Attention Deficit Hyperactivity Disorder (ADHD) but little is known about its association with depression risk in this group. This study aims to establish levels of irritability and prevalence of DMDD in a clinical sample of children with ADHD, and examine their association with anxiety, depression and family history of depression.

Methods: The sample consisted of 696 children (mean age 10.9 years) with a diagnosis of

ADHD, recruited from UK child psychiatry and paediatric clinics. Parents completed the

Child and Adolescent Psychiatric Assessment, a semi-structured diagnostic interview, about