May 1, 2007

The Honorable John D. Dingell, Chairman The Honorable Joe Barton, Ranking Member Energy and Commerce Committee United States House of Representatives 2125 Rayburn House Office Building Washington, D.C. 20515

Dear Chairman Dingell and Ranking Member Barton:

As officers and leaders of the Biotechnology Industry Organization’s (BIO’s) Emerging Companies Section (ECS), we are writing to express support for BIO’s Principles for Follow-On Biologics. BIO’s Emerging Companies Section includes more than 600 small biotechnology companies that are developing their first commercial product and have fewer than 350 employees – 80% of whom have fewer than 50 employees. Attached as well are additional statistics about BIO’s emerging companies and a list of companies.

We appreciate your interest in ensuring that the nation’s citizens have access to safe and affordable biologics. Likewise, BIO’s emerging company members are committed to the development of innovative therapies and making sure that patients have access to these treatments. Furthermore, BIO’s smaller members believe it is critical that any legislation establishing a pathway for the approval of follow on biologics ensure that these products be safe and effective, and maintain incentives for innovation.

Congressional deliberations about developing an approval process for follow-on biologics should include all of the BIO principles (attached). While BIO’s emerging companies are diverse in our business plans, we are cohesive in our support for these principles. We ask that you review these principles and use them as a measuring stick for legislation Congress may consider and as you examine the testimony submitted to the Committee for its recent hearing.

These principles contain the following elements:

Ensure Patient Safety Recognize Scientific Differences Between Drugs and Biologics Maintain the Physician-Patient Relationship Preserve Incentives for Innovation, including respect for intellectual property and other legal rights, non-patent data exclusivity and adequate notice and process rights Ensure Transparent Statutory and Regulatory Processes Continue to Prioritize FDA Review and Approval of New Therapies and Cures

While all of these principles should be central to any statutory pathway for follow-on biologics, failure to provide for substantial data exclusivity and intellectual property protections will be particularly disastrous for emerging biotechnology companies. In the absence of existing product revenue, BIO’s smaller member companies’ ability to invest in cutting edge research is dependent on our ability to attract capital. It is especially important that small biotechnology companies have such access to capital, as such companies account for two-thirds of the industry’s clinical pipeline.

The development of a new biotech therapy is a high-risk investment that is only undertaken based upon the expectation that a future FDA-approved product will provide an attractive return on investment. This process is a delicate balance between the inherently risky prospect of successfully bringing a biologic to market and its future potential. Some of the proposals being considered in Congress would disturb this balance, thereby making it more difficult for emerging biotechnology companies to attract capital. As is, a recent survey of 300 emerging biotech company Chief Executive Officers and Chief Financial Officers found that financial concerns and the ability to raise capital was by far the number one most frequently cited challenge facing their companies (cited by 43% of CEOs and CFOs.).

Emerging biotechnology companies are on the forefront of biomedical advancement and face significant hurdles in successfully delivering safe and effective innovative therapies for patients. It is essential that Congressional deliberations about developing an approval process for follow-on biologics be driven by responsible science, with a focus on protecting patient safety and preserving incentives to innovate, so that new pioneer biotechnology products continue to reach patients and physicians in a timely manner.

We look forward to working with you and your staff in order to ensure that any legislative proposal for follow-on biologics reflect these principles. On behalf of small, emerging biotechnology companies, we appreciate your consideration.

2

Respectfully Submitted,

/s/ /s/

Stephen A. Sherwin, MD Rachel K. King Chairman Vice Chair ECS Governing Body ECS Governing Body Chairman & CEO Chief Executive Officer Cell Genesys, Inc GlycoMimetics, Inc

/s/ /s/

Mark W. Schwartz, PhD Harold E. Van Wart, PhD Co-Chair Co-Chair ECS Health and Regulatory ECS Health and Regulatory Standing Committee Standing Committee President & CEO President, CEO & Director Bayhill Therapeutics, Inc Metabolex, Inc

Attachments

3 BIO’s Emerging Companies

70% of Emerging Companies Are Private: Latest Round of Venture Financing Private vs. Public 30 Completed

30% Public 20 70% Private 10 Percentage

0 Seed Series A Series B Series C Series D Series E Stage 30% Of Emerging Companies Are Public: Market Capitalization As of 4/23/2007 100 80 60 70% 40 16% 7% 4% 3% 20

Companies 0 1-250 251-500 501-750 751-1000 1001+ Market Cap ($ Millions) BIO’s Emerging Companies

How many products/candidates is your company pursuing throughout all stages of development?

Average Number Of Products Average Number Of Products In Being Developed By The Each Development Phase Company’s Latest Stage Of 16 Development For Lead Product 16 Overall 14 Average 14 Pre-Clinical 12 12 10 10 Phase I 10 8 Phase II 8 6.1 6 5.2 Phase III 6 4.9 4 3.1 4 2.9 2 2 1 0.9 0.4 0 0 Pre-Clinical Phase 1 Phase 2 Phase 3 BIO Emerging Companies By State

Company Name City Alabama BioCryst Pharmaceuticals, Inc. Birmingham Arizona AmpliMed Corporation Tucson Apthera, Inc Scottsdale ImaRx Therapeutics, Inc Tucson InNexus Biotechnology, Inc. Scottsdale Systems Medicine, Inc Tucson Virionics Corporation Scottsdale California ACADIA Pharmaceuticals, Inc San Diego Acidophil, LLC La Jolla Acologix, Inc Hayward Acumen Pharmaceuticals, Inc South San Francisco Advenchen Laboratories Northridge ADVENTRX Pharmaceuticals, Inc San Diego Aerovance, Inc Berkeley Affitech AS Walnut Creek Affymax, Inc Palo Alto Agensys, Inc Santa Monica Aires Pharmaceuticals San Diego Akesis Pharmaceuticals La Jolla Alexza Pharmaceuticals, Inc Palo Alto Alliance Pharmaceutical Corporation San Diego Ambit Biosciences Corporation San Diego Ambrx, Inc La Jolla Anacor Pharmaceuticals, Inc Palo Alto Anadys Pharmaceuticals, Inc San Diego Androclus Therapeutics, Inc San Diego Anesiva, Inc South San Francisco Antara Biosciences, Inc Mountain View Antibody Solutions Mountain View Arbor Vita Corporation Sunnyvale Arena Pharmaceuticals, Inc San Diego Arriva Pharmaceuticals, Inc Alameda ARYx Therapeutics, Inc Fremont Ascenta Therapeutics, Inc San Diego Athenagen, Inc South San Francisco Avera Pharmaceuticals, Inc San Diego Avigen, Inc Alameda Bayhill Therapeutics, Inc Palo Alto Bebaas, Inc Newport Beach Bioabsorbable Therapeutics, Inc Menlo Park BioBancUSA Monterey BioCatalytics, Inc Pasadena Biocept, Inc San Diego Bionovo, Inc Emeryville BioSeek, Inc Burlingame BrainCells, Inc San Diego Cadence Pharmaceuticals, Inc. San Diego Cardio Dx Palo Alto Catalyst Biosciences, Inc South San Francisco Cell Genesys, Inc South San Francisco Cellerant Therapeutics, Inc San Carlos CellGate, Inc Redwood City Celltrion, Inc South San Francisco Ceregene, Inc San Diego Cerimon Pharmaceuticals, Inc South San Francisco CG Pharmaceuticals Emeryville Chemical Diversity Labs, Inc. San Diego ChemoCentryx, Inc Mountain View Conatus Pharmaceuticals, Inc San Diego ConfometRx, Inc Palo Alto Conforma Therapeutics Corporation San Diego CS Bio, Inc Menlo Park Cypress Bioscience, Inc San Diego Cytokinetics, Inc South San Francisco CytRx Corporation Los Angeles diaDexus, Inc South San Francisco DiObex, Inc San Francisco DNA 2.0, Inc Menlo Park Entelos, Inc Foster City Essentialis, Inc Carlsbad FivePrime Therapeutics, Inc San Francisco Fundamental Applied Biology, Inc Menlo Park Genelabs Technologies, Inc Redwood City GenSpera, Inc Santa Monica GEO Pharmaceuticals, Inc San Leandro Geron Corporation Menlo Park Halozyme Therapeutics, Inc San Diego Hana Biosciences, Inc South San Francisco Hermes Biosciences, Inc South San Francisco Hollis-Eden Pharmaceuticals, Inc. San Diego HTD BioSystems, Inc Hercules Ichor Medical Systems, Inc San Diego Ilypsa, Inc Santa Clara ImmPORT Therapeutics, Inc Irvine Immune Response Corporation Carlsbad Innovative NeuroTechnologies, Inc Irvine Inovio Biomedical Corporation San Diego Inverseon, Inc San Francisco Isis Pharmaceuticals, Inc Carlsbad Juvaris BioTherapeutics, Inc Pleasanton Kadmus Pharmaceuticals, Inc Irvine KAI Pharmaceuticals, Inc South San Francisco KaloBios Pharmaceuticals, Inc Palo Alto Kemia, Inc San Diego KineMed, Inc Emeryville Kinexis, Inc San Diego Kissei America, Inc Irvine Kosan Biosciences, Inc. Hayward La Jolla Pharmaceutical Company San Diego Labcyte Inc Sunnyvale Ligand Pharmaceuticals, Inc San Diego Limerick NeuroSciences, Inc South San Francisco Lipomics Technologies, Inc West Sacramento MAP Pharmaceuticals Mountain View MediciNova, Inc San Diego Medivation, Inc San Francisco Metabasis Therapeutics, Inc La Jolla Metabolex, Inc Hayward Meyer Pharmaceuticals, LLC Irvine Micromet, Inc Carlsbad moksha8 San Francisco Napo Pharmaceuticals, Inc South San Francisco Nascent Pharmaceuticals, Inc Burlingame National Genecular Institute Newport Beach Nativis, Inc Del Mar Neugenesis Corporation Burlingame Neurobiological Technologies, Inc Emeryville NeuroGeneration, Inc Los Angeles NovaBay Pharmaceuticals, Inc Emeryville Novacea, Inc South San Francisco Novalar Pharmaceuticals, Inc. San Diego Novasite Pharmaceuticals, Inc San Diego , Inc San Carlos Nventa Corporation San Diego Odyssey Thera, Inc San Ramon Onchemie Pharmaceuticals Pleasanton OncoMed Pharmaceuticals, Inc Mountain View Onyx Pharmaceuticals, Inc Emeryville Orexigen Therapeutics, Inc San Diego Orphagen Pharmaceuticals, Inc San Diego Osteologix, Inc San Francisco OxyBand Technologies, Inc Mill Valley Perlegen Sciences, Inc Mountain View Pharmix Corporation Brisbane Phenomix Corporation San Diego PhyNexus, Inc San Jose Polygenetics, Inc Los Gatos Poniard Pharmaceuticals, Inc South San Francisco Portola Pharmaceuticals, Inc South San Francisco Prediction Sciences, Inc La Jolla Presidio Pharmaceuticals, Inc San Francisco Proteolix, Inc South San Francisco ProteomTech, Inc Costa Mesa Raptor Pharmaceutical, Inc Novato Raven Biotechnologies, Inc South San Francisco Receptor Biologix, Inc South San Francisco Renovis, Inc South San Francisco Revance Therapeutics, Inc Mountain View Rigel, Inc. South San Francisco Rincon Pharmaceuticals, Inc La Jolla ROXRO Pharma, Inc Menlo Park Saegis Pharmaceuticals, Inc Half Moon Bay San Jose BioCenter San Jose SanBio, Inc. Mountain View Sangamo BioSciences, Inc Richmond Sequenom, Inc San Diego SGX Pharmaceuticals, Inc San Diego Sirna Therapeutics, Inc San Francisco SomaGenics, Inc Santa Cruz Somaxon Pharmaceuticals, Inc San Diego , Inc Irvine Sunesis Pharmaceuticals, Inc South San Francisco SuperGen, Inc Dublin SwitchGear Genomics Menlo Park Tacere Therapeutics, Inc San Jose Target Discovery, Inc Palo Alto Telik, Inc Palo Alto Tercica, Inc Brisbane Threshold Pharmaceuticals, Inc Redwood City Thuris Corporation Irvine , Inc South San Francisco TorreyPines Therapeutics, Inc La Jolla Tracon Pharmaceuticals, Inc San Diego TransOral Pharmaceuticals, Inc Point Richmond Trellis Bioscience, Inc South San Francisco Urigen NA, Inc Burlingame Valentis, Inc Burlingame VentiRx Pharmaceuticals, Inc San Diego Vical, Inc San Diego Victory Pharma, Inc San Diego VISTAGEN THERAPEUTICS, INC. Burlingame Wave 80 Biosciences, Inc San Francisco West Coast Biologicals, Inc San Francisco XDx, Inc South San Francisco Xencor, Inc Monrovia XenoPort, Inc Santa Clara XOMA Ltd Berkeley Xytis, Inc Irvine YODAN Biotech Palo Alto Colorado Allos Therapeutics, Inc Westminster Ceragenix Pharmaceuticals, Inc Denver GlobeImmune, Inc Aurora Lead Horse Technologies, Inc Aurora MBC Pharma, Inc Boulder PharmaJet, Inc Golden Replidyne, Inc. Louisville Source MDx Boulder Connecticut , Inc Cheshire Artificial Cell Technologies, Inc New Haven ARVYS Proteins, Inc Stamford BioXcel Corporation Guilford CuraGen Corporation New Haven HistoRx, Inc New Haven Marinus Pharmaceuticals, Inc Branford Protein Sciences Corporation Meriden RHEI Pharmaceuticals, Inc New Haven Delaware Incyte Corporation Wilmington Florida Akron Biotechnology, LLC Boca Raton DOR BioPharma, Inc Miami St. Charles Pharmaceuticals, Inc Alachua Tigris Pharmaceuticals, Inc Bonita Springs Viragen, Inc Plantation Xcovery, Inc West Palm Beach Georgia AerovectRx Corporation Atlanta Inc Alpharetta Altea Therapeutics Corporation Tucker AtheroGenics, Inc Alpharetta AviGenics, Inc Athens Corautus Genetics, Inc Atlanta Hawaii BioXene, Inc Honolulu Cardax Pharmaceuticals, Inc Aiea Iowa BioForce Nanosciences, Inc Ames Illinois Advanced Life Sciences, Inc Woodridge BioSante Pharmaceuticals, Inc Lincolnshire Celsis, Inc Chicago Chromatin, Inc Chicago Geneve Bio, Inc Wheeling Kim Laboratories, Inc Champaign Midwest Research Laboratories, LLC Lake Forest , Inc Deerfield PSR Global Genetics LLC Sugar Grove ZelleRx Corporation Chicago Indiana Ash Access Technology, Inc Lafayette Cook Pharmica, LLC Bloomington Endocyte, Inc West Lafayette Jubilant Innovation, Ltd Greenwood Kansas Cydex, Inc Lenexa ImmunoGenetix Therapeutics, Inc Lenexa VasoGenix Pharmaceuticals, Inc Lenexa Kentucky Intranasal Therapeutics, Inc Lexington Louisiana U.S. Antigens Corporation Baton Rouge Massachusetts Acceleron Pharma, Inc Cambridge Acretia, Inc Lexington ActivBiotics, Inc Lexington Acusphere, Inc Watertown Adnexus Therapeutics, Inc Waltham , Inc Cambridge Altus Pharmaceuticals, Inc Cambridge Apogee Technology, Inc Norwood Arbios Systems, Inc Waltham Artisan Pharma, Inc Framingham AVANT Immunotherapeutics, Inc Needham BG Medicine, Inc Waltham BioVex, Inc Cambridge Boston Life Sciences, Inc Hopkinton Cambria Biosciences LLC Woburn Cequent Pharmaceuticals, Inc Cambridge Coley Pharmaceutical Group, Inc Wellesley CombinatoRx, Inc Cambridge Critical Therapeutics, Inc Lexington Curis, Inc Cambridge Dyax Corporation Cambridge Dynogen Pharmaceuticals, Inc Waltham Elixir Pharmaceuticals, Inc Cambridge EnVivo Pharmaceuticals, Inc Watertown EXACT Sciences Corporation Marlborough EyeGate Pharmaceuticals, Inc Waltham Gloucester Pharmaceuticals, Inc Cambridge GTC Biotherapeutics, Inc Framingham Hydra Biosciences, Inc Cambridge Idenix Pharmaceuticals, Inc Cambridge Idera Pharmaceuticals, Inc Cambridge ImmunoGen, Inc Cambridge Infinity Pharmaceuticals, Inc Cambridge Javelin Pharmaceuticals, Inc Cambridge Keel Pharmaceuticals, Inc Cambridge MacroChem Corporation Lexington Magen BioSciences, Inc. Cambridge Mercury Therapeutics, Inc Woburn Merrimack Pharmaceuticals, Inc Cambridge Mersana Therapeutics, Inc Cambridge Microbia, Inc Cambridge Molecular Insight Pharmaceuticals, Inc Cambridge Momenta Pharmaceuticals, Inc Cambridge MSM Protein Technologies Inc Medford NeuroHealing Pharmaceuticals, Inc Newton Paratek Pharmaceuticals, Inc Boston Peptimmune, Inc Cambridge PGxHealth LLC Newton Point Therapeutics, Inc Boston Pro-Pharmaceuticals, Inc Newton RepliGen Corporation Waltham RiboNovix, Inc. Lincoln Sirtris Pharmaceuticals, Inc Cambridge Surface Logix, Inc Brighton Syntonix Pharmaceuticals, Inc Waltham Targeted Cell Therapies, LLC Shrewsbury The GI Company, Inc Framingham Therion Biologics Corporation Cambridge TolerRx, Inc Cambridge TransMolecular, Inc Cambridge Trine Pharmaceuticals, Inc Waltham Valeo Medical, Inc Burlington Xanthus Pharmaceuticals, Inc Cambridge Xcellerex, Inc Marlborough ZIOPHARM Oncology, Inc Charlestown Maryland 20/20 GeneSystems, Inc Rockville Advancis Pharmaceutical Corporation Germantown Alba Therapeutics Corporation Baltimore Avalon Pharmaceuticals, Inc Germantown CoGenesys, Inc Rockville Compugen USA, Inc Rockville Correlogic Systems, Inc. Rockville CytImmune Sciences, Inc Rockville EntreMed, Inc Rockville Expression Pathology, Inc Gaithersburg FASgen, Inc Baltimore GenVec, Inc Gaithersburg GlycoMimetics, Inc Gaithersburg HumanAutoCell, Inc Bethesda Immunomic Therapeutics, Inc Gaithersburg IOMAI Corporation Gaithersburg Lentigen Corporation Baltimore MacroGenics, Inc Rockville MaxCyte, Inc Gaithersburg Mosaigen, Inc Rockville Novavax, Inc Rockville Panacea Pharmaceuticals, Inc Gaithersburg Panacos Pharmaceuticals, Inc Gaithersburg PharmAthene, Inc Annapolis Profectus BioSciences, Inc Baltimore RegeneRx Biopharmaceuticals, Inc Bethesda Ruxton Pharmaceuticals, Inc Lutherville Sequella, Inc Rockville Sequoia Pharmaceuticals, Inc Gaithersburg Synergy America, Inc Gaithersburg Traxion Therapeutics Inc Baltimore Trophogen, Inc Rockville Vanda Pharmaceuticals Inc Rockville VIRxSYS Corporation Gaithersburg Zylacta Corporation Boyds Michigan Aastrom Biosciences, Inc Ann Arbor Apolife, Inc Detroit Cerenis Therapeutics Ann Arbor Fusion Therapeutics, Inc Ann Arbor Genetics Squared, Inc Ann Arbor NanoBio Corporation Ann Arbor Pipex Pharmaceuticals, Inc Ann Arbor QuatRx Pharmaceuticals, Inc Ann Arbor BIOTHERA Eagan Minnesota Medisyn Technologies, Inc Minnetonka PepTx, Inc Saint Paul Missouri Kereos, Inc St Louis Orion Genomics, LLC St. Louis Montana LigoCyte Pharmaceuticals, Inc. Bozeman North Carolina AlphaVax, Inc Research Triangle Park Argos Therapeutics, Inc Durham Asklepios , Inc Chapel Hill Athenix Corporation Research Triangle Park , Inc Pittsboro Chelsea Therapeutics, Inc Charlotte Chimerix, Inc Durham Cirrus Pharmaceuticals, Inc. Research Triangle Park Cygnus Technologies, Inc Southport Entegrion, Inc Research Triangle Park Erimos Pharmaceuticals, LLC Raleigh Expression Analysis, Inc Durham Gentris Morrisville Icagen, Inc Durham ImmunoBiosciences, Inc Raleigh Kowa Research Institute, Inc Morrisville Nartest Technologies, LLC Morrisville Phase Bioscience, Inc Durham Qualyst, Inc Raleigh Regado Biosciences, Inc Durham Serenex, Inc Durham Targacept, Inc Winston-Salem Thrombotargets Corporation Durham TransTech Pharma, Inc High Point Tranzyme, Inc Durham World Ocean Solutions, Inc Wilmington Nebraska Transgenomic, Inc Omaha New Jersey Actinium Pharmaceuticals, Inc Florham Park Aegerion Pharmaceuticals, Inc Bridgewater AkaRx, Inc Paramus Alfacell Corporation Bloomfield Amicus Therapeutics, Inc Cranbury Anadis Ltd (USA) Closter BioNanomatrix, Inc Titusville BioWa, Inc Princeton EluSys Therapeutics, Inc Pinebrook EpiCept Corporation Englewood Cliffs Genmab, Inc Princeton , Inc Berkeley Heights GPC Biotech, Inc Princeton Lifeblood Medical, Inc Freehold Memory Pharmaceuticals Corporation Montvale Neurologix, Inc Fort Lee Onconova Therapeutics, Inc Lawrenceville Palatin Technologies, Inc Cranbury PBL Therapeutics, Inc Piscataway Pharmacopeia Drug Discovery, Inc Princeton Pharmos Corporation Iselin Phyton Biotech, Inc East Windsor Provid Pharmaceuticals, Inc Piscataway PTC Therapeutics, Inc South Plainfield Redpoint Bio Corporation Cranbury SMART Biosciences, Inc Princeton Stem Cell Innovations Princeton SyntheMed, Inc. Iselin Transave, Inc Monmouth Junction VaxInnate Corporation Cranbury VioQuest Pharmaceuticals, Inc Basking Ridge WellGen, Inc. New Brunswick X-Cell Medical, Inc. Monmouth Junction New York , Inc Hawthorne Antigenics, Inc New York Aureon Laboratories, Inc Yonkers Callisto Pharmaceuticals, Inc New York Cara Therapeutics, Inc Tarrytown FermaVir Pharmaceuticals, Inc New York Innovive Pharmaceuticals, Inc New York Intercept Pharmaceuticals, Inc New York Lev Pharmaceuticals, Inc New York Manhattan Pharmaceuticals, Inc New York NexGenix Pharmaceuticals Holdings, Inc New York PeriCor Therapeutics, Inc New York PsychoGenics, Inc Tarrytown Rondaxe Pharma, LLC Syracuse SIGA Technologies, Inc New York Tactical Therapeutics Inc New York Vaccinex, Inc Rochester Ohio Akebia Therapeutics Cincinnati Athersys, Inc Cleveland Copernicus Therapeutics, Inc Cleveland Copernicus Therapeutics, Inc. Cleveland Neoprobe Corporation Dublin Ventaira Pharmaceuticals, Inc Columbus Oklahoma Selexys Pharmaceuticals Corp Oklahoma City Pennsylvania Acceptys, Inc Malvern Acuity Pharmaceuticals, Inc Philadelphia Acureon Pharma Berwyn Adolor Corporation Exton Alita Pharmaceuticals, Inc Radnor Apogee Biotechnology Corporation Hershey Avid Radiopharmaceuticals, Inc Philadelphia Azevan Pharmaceuticals, Inc Bethlehem Beijing Med-Pharm Corporation Plymouth Meeting BioSense Corporation Doylestown Cardiokine, Inc Philadelphia Cerionx, Inc Exton Curedm Wynnewood Discovery Laboratories, Inc Warrington FemmePharma Inc. Wayne Genaera Corporation Plymouth Meeting Keystone Nano, Inc Boalsburg Locus Pharmaceuticals, Inc Blue Bell , Inc Exton Neose Technologies, Inc Horsham Neose Technologies, Inc. Horsham Neotropix, Inc Malvern Nucleonics, Inc Horsham NuPathe, Inc Fort Washington Othera Pharmaceuticals, Inc Exton Parsortix, Inc Philadelphia PolyMedix, Inc Philadelphia Prism Pharmaceuticals, Inc King of Prussia Promedior, Inc Malvern Protalex, Inc New Hope Protez Pharmaceuticals, Inc Malvern Puresyn, Inc Malvern Targeted Diagnostics & Therapeutics, Inc West Chester TetraLogic Pharmaceuticals Corporation Malvern Topaz Pharmaceuticals LLC Jenkintown Zelos Therapeutics, Inc West Conshohocken Rhode Island Neurotech USA, Inc Lincoln South Carolina Argolyn Bioscience, Inc North Charleston FirstString Research, Inc North Charleston Oncolix, Inc Greenville Tennessee BioMimetic Therapeutics, Inc. Franklin Texas ApoCell, Inc Houston Encysive Pharmaceuticals, Inc Houston HemoBioTech, Inc Dallas Introgen Therapeutics, Inc Austin Nanospectra Biosciences, Inc Houston OncoVista, Inc San Antonio Plantacor, Inc College Station PLx Pharma, Inc Houston Reata Pharmaceuticals, Inc Irving , Inc Houston Utah Axial Biotech, Inc Salt Lake City Paleotechnology, Inc Salt Lake City Q Therapeutics, Inc Salt Lake City Virginia Adenosine Therapeutics, LLC Charlottesville BioRosettex Corporation Arlington CEL-SCI Corporation Vienna Diffusion Pharmaceuticals, LLC Charlottesville Insmed, Inc Richmond Revivicor, Inc Blacksburg Tessarae Inc/LLC Mc Lean Washington Acucela, Inc Bothell Alder BioPharmaceuticals, Inc Bothell BioPharmica Ltd East Perth Calistoga Pharmaceuticals, Inc. Seattle Cell Therapeutics, Inc Seattle Dendreon Corporation Seattle Helix BioMedix, Inc Bothell Koronis Pharmaceuticals, Inc Redmond Kurve Technology, Inc Bothell Light Sciences Corporation Snoqualmie MediQuest Therapeutics, Inc Bothell Nastech Pharmaceutical Company, Inc Bothell Northwest Biotherapeutics, Inc Bothell Onconome, Inc Seattle Phylogica, Ltd Subiaco Sangretech Biomedical LLC Seattle Seattle Genetics, Inc Bothell Sound Pharmaceuticals, Inc Seattle Targeted Genetics Corporation Seattle VLST Corporation Seattle Wisconsin ConjuGon, Inc Madison EraGen Biosciences, Inc Madison Gala Biotech business unit of Cardinal Health Middleton GeriGene Medical Corporation Elkhart Lake ZyStor Therapeutics, Inc Milwaukee