Polyclonal Antibody to Stabilin 1 / STAB1 (C-Term) - Aff - Purified

OriGene Technologies, Inc. OriGene Technologies GmbH

9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected]

AP33007PU-N Polyclonal Antibody to Stabilin 1 / STAB1 (C-term) - Aff - Purified

Alternate names: CLEVER-1, EGF-like, FEEL-1, FEEL1, Fasciclin, KIAA0246, Stabilin-1, laminin-type EGF- like and link domain-containing scavenger receptor 1 Quantity: 0.1 mg Concentration: 0.5 mg/ml Background: Stabilin-1 is a large transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes (Entrez gene 23166). Cellular localization: Membrane; Single-pass type I membrane protein. Uniprot ID: Q9NY15 NCBI: NP_055951.2 GeneID: 23166 Host: Goat Immunogen: Peptide with sequence C-DFPDTQRILTVK, from the C Terminus of the protein sequence according to NP_055951.2. Genename: STAB1 Format: State: Liquid purfied Ig fraction Purification: Antigen Affinity Chromatography Buffer System: Tris saline, pH~7.3 Preservatives: 0.02% Sodium Azide Stabilizers: 0.5% BSA Applications: Peptide ELISA: 1/8000 (Detection Limit). Immunohistochemistry on Paraffin Sections: 3-5 µg/ml. In paraffin embedded Human Spleen shows endothelial staining. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Specificity: This antibody recognizes Stabilin-1 at C-term. Species Reactivity: Tested: Human. Expected from sequence similarity: Bovine, Canine and Pig. Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. MS/20131021 1 / 2 AP33007PU-N: Polyclonal Antibody to Stabilin 1 / STAB1 (C-term) - Aff - Purified

Pictures: Staining of paraffin embedded Human Spleen using Stabilin 1 Antibody Cat.-No AP33007PU-N at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. MS/20131021 2 / 2