IFMBE Proceedings Volume 22/1

Series Editors: R. Magjarevic and J. H. Nagel

The International Federation for Medical and Biological Engineering, IFMBE, is a federation of national and transnational organizations representing internationally the interests of medical and biological engineering and sciences. The IFMBE is a non-profit organization fostering the creation, dis- semination and application of medical and biological engineering knowledge and the management of technology for improved health and quality of life. Its activities include participation in the formulation of public policy and the dissemination of information through publications and forums. Within the field of medical, clinical, and biological engineering, IFMBE’s aims are to encourage research and the application of knowledge, and to disseminate information and promote collaboration. The objectives of the IFMBE are scientific, technological, literary, and educational. The IFMBE is a WHO accredited NGO covering the full range of biomedical and clinical engineering, healthcare, healthcare technology and man- agement. It is representing through its 58 member societies some 120.000 professionals involved in the various issues of improved health and health care delivery. IFMBE Officers President: Makoto Kikuchi, Vice-President: Herbert Voigt, Former-President: Joachim H. Nagel Treasurer: Shankar M. Krishnan, Secretary-General: Ratko Magjarevic http://www.ifmbe.org

Previous Editions: IFMBE Proceedings ECIFMBE 2008 “4th European Conference of the International Federation for Medical and Biological Engineering”, Vol. 22, 2008, Antwerp, Belgium, CD IFMBE Proceedings BIOMED 2008 “4th Kuala Lumpur International Conference on Biomedical Engineering”, Vol. 21, 2008, Kuala Lumpur, Malaysia, CD IFMBE Proceedings NBC 2008 “14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics”, Vol. 20, 2008, Riga, Latvia, CD IFMBE Proceedings APCMBE 2008 “7th Asian-Pacific Conference on Medical and Biological Engineering”, Vol. 19, 2008, Beijing, China, CD IFMBE Proceedings CLAIB 2007 “IV Latin American Congress on Biomedical Engineering 2007, Bioengineering Solution for Latin America Health”, Vol. 18, 2007, Margarita Island, Venezuela, CD IFMBE Proceedings ICEBI 2007 “13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography”, Vol. 17, 2007, Graz, Austria, CD IFMBE Proceedings MEDICON 2007 “11th Mediterranean Conference on Medical and Biological Engineering and Computing 2007”, Vol. 16, 2007, Ljubljana, Slovenia, CD IFMBE Proceedings BIOMED 2006 “Kuala Lumpur International Conference on Biomedical Engineering”, Vol. 15, 2004, Kuala Lumpur, Malaysia, CD IFMBE Proceedings WC 2006 “World Congress on Medical Physics and Biomedical Engineering”, Vol. 14, 2006, Seoul, Korea, DVD IFMBE Proceedings BSN 2007 “4th International Workshop on Wearable and Implantable Body Sensor Networks”, Vol. 13, 2006, Aachen, Germany IFMBE Proceedings ICBMEC 2005 “The 12th International Conference on Biomedical Engineering”, Vol. 12, 2005, Singapore, CD IFMBE Proceedings EMBEC’05 “3rd European Medical & Biological Engineering Conference, IFMBE European Conference on Biomedical Engineering”, Vol. 11, 2005, Prague, Czech Republic, CD IFMBE Proceedings ICCE 2005 “The 7th International Conference on Cellular Engineering”, Vol. 10, 2005, Seoul, Korea, CD IFMBE Proceedings NBC 2005 “13th Nordic Baltic Conference on Biomedical Engineering and Medical Physics”, Vol. 9, 2005, Umeå, Sweden IFMBE Proceedings APCMBE 2005 “6th Asian-Pacific Conference on Medical and Biological Engineering”, Vol. 8, 2005, Tsukuba, Japan, CD IFMBE Proceedings BIOMED 2004 “Kuala Lumpur International Conference on Biomedical Engineering”, Vol. 7, 2004, Kuala Lumpur, Malaysia IFMBE Proceedings MEDICON and HEALTH TELEMATICS 2004 “X Mediterranean Conference on Medical and Biological Engineering”, Vol. 6, 2004, Ischia, Italy, CD IFMBE Proceedings 3rd Latin – American Congress on Biomedical Engineering “III CLAEB 2004”, Vol. 5, 2004, Joao Pessoa, Brazil, CD

IFMBE Proceedings Vol. 22/1 Jos Vander Sloten · Pascal Verdonck · Marc Nyssen · Jens Haueisen (Eds.)

4th European Conference of the International Federation for Medical and Biological Engineering

ECIFMBE 2008 23–27 November 2008 Antwerp, Belgium

123

Editors

Jos Vander Sloten Marc Nyssen KULeuven Free University Brussels Biomechanics and Engineering Design Section Medical Informatics Department Celestijnenlaan 300c - bus 2419 Laarbeeklaan 103 3001 Heverlee 1090 Brussels Belgium Belgium

Pascal Verdonck Jens Haueisen Ghent University Technical University of Ilmenau Cardiovascular Mechanics Institute for Biomedical Engineering and Informatics and Biofluid Dynamics Research Unit P.O. Box 100565 De Pintelaan 185 98639 Ilmenau 9000 Gent Germany Belgium

ISSN 1680-0737 ISBN-13 978-3-540-89207-6 e-ISBN-13 978-3-540-89208-3

DOI 10.1007/978-3-540-89208-3

Library of Congress Control Number: 2008939398

© International Federation of Medical and Biological Engineering 2008

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permissions for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law.

The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

The IFMBE Proceedings is an Offical Publication of the International Federation for Medical and Biological Engineering (IFMBE)

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About IFMBE

The International Federation for Medical and Biological Engineering (IFMBE) was established in 1959 to provide medical and biological engineering with a vehicle for international collaboration in research and practice of the profession. The Fed- eration has a long history of encouraging and promoting international cooperation and collaboration in the use of science and engineering for improving health and quality of life. The IFMBE is an organization with membership of national and transnational societies and an International Academy. At present there are 52 national members and 5 transnational members representing a total membership in excess of 120 000 worldwide. An observer category is provided to groups or organizations considering formal affiliation. Personal membership is possible for individuals living in countries without a member society The International Academy includes individuals who have been recognized by the IFMBE for their outstanding contributions to biomedical engineering.

Objectives The objectives of the International Federation for Medical and Biological Engineering are scientific, technological, literary, and educational. Within the field of medical, clinical and biological engineering it’s aims are to encourage research and the application of knowledge, and to disseminate information and promote collaboration. In pursuit of these aims the Federation engages in the following activities: sponsorship of national and international meet- ings, publication of official journals, cooperation with other societies and organizations, appointment of commissions on special problems, awarding of prizes and distinctions, establishment of professional standards and ethics within the field, as well as other activities which in the opinion of the General Assembly or the Administrative Council would further the cause of medical, clinical or biological engineering. It promotes the formation of regional, national, international or specialized societies, groups or boards, the coordination of bibliographic or informational services and the improvement of standards in terminology, equipment, methods and safety practices, and the delivery of health care. The Federation works to promote improved communication and understanding in the world community of engineering, medicine and biology.

Activities Publications of IFMBE include: the journal Medical and Biological Engineering and Computing, the electronic magazine IFMBE News, and the Book Series on Biomedical Engineering. In cooperation with its international and regional confer- ences, IFMBE also publishes the IFMBE Proceedings Series. All publications of the IFMBE are published by Springer Ver- lag. The Federation has two divisions: Clinical Engineering and Health Care Technology Assessment. Every three years the IFMBE holds a World Congress on Medical Physics and Biomedical Engineering, organized in co- operation with the IOMP and the IUPESM. In addition, annual, milestone and regional conferences are organized in different regions of the world, such as Asia Pacific, Europe, the Nordic-Baltic and Mediterranean regions, Africa and Latin America. The administrative council of the IFMBE meets once a year and is the steering body for the IFMBE: The council is sub- ject to the rulings of the General Assembly, which meets every three years. Information on the activities of the IFMBE can be found on the web site at: http://www.ifmbe.org.

Welcome to Antwerp!

Dear colleagues, in name of all organizers, a cordial welcome to you in Antwerp on the occasion of the 4th European Conference for Medical and Biomedical Engineering, which is the 4th European Conference of the International Federation for Medical and Biome- dical Engineering. The previous meetings were successfully organized twice in Vienna (1995 and 1999), and once in Prague (2005). Antwerp has a long standing tradition of openness to the world, as a cosmopolitan city as one of the great harbors and cul- tural centers of our continent. The symbol of the city is the hero Brabo, throwing the hand of the villain giant Antigoon he just defeated in combat into the river Schelde. It shows that the spirit of independence in this region of the world defeats tyrants. It also reveals the shift in emphasis over time: in the dark ages limbs were cut off from people, in our times we en- gage into challenges to restore and repair cells, organs, limbs … the whole body, thanks to the collaboration of medicine and engineering. The theme of the Antwerp Conference: ‘Engineering for Health’ aims to highlight this interactive collaboration. It also links to the current concepts on translational medicine, transferring research findings from the bench to industry and to the bed of the patient. From the start, the scientific committees were composed of both engineers and physicians and thanks to this we have elaborated a unique scientific program structured in seven tracks, embracing the rich field of biomedical engi- neering: • Signal and image processing and ICT • Clinical engineering and applications • Biomechanics • Biomaterials and tissue repair • Innovations and nanotechnology • Modeling and simulation • Education and profession Thanks to the co-sponsorship of IFMBE and endorsement of the European societies ESEM and EAMBES, the German society DGBMT, the Belgian Society BSMBEC was able to organize this conference.

We wish you an excellent conference, a productive meeting and enjoyable stay in Antwerp!

The Conference chairmen:

Prof. Marc Nyssen Prof. Jos Vander Sloten Prof. Pascal Verdonck Prof. Jens Haueisen

Conference details

Name Artmann, Gerhard (Jülich, Germany) 4th European Conference of the International Federation Arvanitis, Theo (Birmingham, UK) for Medical and Biological Engineering Aubert, André (Leuven, Belgium) Baets, Roeland (Ghent, Belgium) Short name Bamidis, Panagiotis D. (Thessaloniki, Greece) ECIFMBE 2008 Bartic, Carmen (Leuven, Belgium) Bijnens, Bart (Leuven, Belgium) Venue Blinowska, Katarzyna (Warsaw, Poland) Antwerp, Belgium Bosmans, Hilde (Leuven, Belgium) 23–27 November, 2008 Brimioulle, Serge (Brussels, Belgium) Buzug, Thorsten (Lübeck, Germany) In cooperation with Caemaert, Jacques (Ghent, Belgium) ESEM Congress 2008 Calil Said, Jorge (Zeferino Vaz, Brazil) BMT 2008 – 40th Annual Conference of the German Catelli Infantosi, Antonio F. (Rio de Janeiro, Brazil) Society for Biomedical Engineering within VDE Ceelen, Wim (Ghent, Belgium) IEEE-EMBS Benelux Chapter Symposium 2008 Claessens, Tom (Ghent, Belgium) Clarys, Jan (Brussels, Belgium) Endorsed by Colardyn, Francis (Ghent, Belgium) EAMBES Cornelis, Jan (Brussels, Belgium) Cornelissen, Ria (Ghent, Belgium) Local Organising Committee Costin, Hariton (Iasi, Romania) D’Asseler, Yves (Ghent, Belgium) Chairmen/Editors D’Hooge, Jan (Leuven, Belgium) Vander Sloten, Jos De Backer, Jan (Antwerp, Belgium) Haueisen, Jens De Backer, Wilfried (Antwerp, Belgium) Nyssen, Marc De Beule, Matthieu (Ghent, Belgium) Verdonck, Pascal De Deene, Yves (Ghent, Belgium) De Moor, Georges (Ghent, Belgium) Members De Moor, Bart (Leuven, Belgium) Brimioulle, Serge De Ridder, Dirk (Antwerp, Belgium) Cornelis, Jan De Sutter, Johan (Ghent, Belgium) De Wachter, Dirk De Wagter, Carlos (Ghent, Belgium) Delbeke, Jean Deconinck, Frank (Brussels, Belgium) Delchambre, Alain Decramer, Mark (Leuven, Belgium) Kolh, Philippe Deklerck, Rudi (Brussels, Belgium) Lambrecht, Luc Delbeke, Jean (Brussels, Belgium) Lefèvre, Philippe Dickhaus, Hartmunt (Heilbronn, Germany) Lemahieu, Ignace Dierckx, Rudi (Ghent, Belgium) Peeters, Stefaan Dössel, Olaf (Karksruhe, Germany) Van der Perre, Georges Dubruel, Peter (Ghent, Belgium) Van Huffel, Sabine Duifhuis, Hendrikus (Groningen, The Netherlands) Wuyts, Floris Eberle, Wolfgang (IMEC Leuven, Belgium) Epple, Matthias (Essen, Germany) Scientific committee list Ermert, Helmut (Bochum, Germany) Achten, Rik (Ghent, Belgium) Fiers, Tom (Ghent, Belgium) Adam, Dan (Haifa, Israel) Flandre, Denis (Louvain-La-Neuve, Belgium) Ambrosio, Luigi (Naples, Italy) Friesdorf, Wolfgang (Berlin, Germany) X Conference details

Gehring, Hartmut (Lübeck, Germany) Luyten, Frank (Leuven, Belgium) Gelinsky, Michael (Dresden, Germany) Maess, Burkhard (Leipzig, Germany) Geris, Liesbet (Leuven, Belgium) Magjarevic, Ratko (Zagreb, Croatia) Gielen, Jan (Antwerp, Belgium) Maglaveras, Nicos (Thessaloniki, Greece) Gilly, Hermann (Vienna, Austria) Malberg, Hagen (Egggenstein-Leopoldshafen, Germany) Goh Cho Hong, James (Singapore, Singapore) Maniewski, Roman (Warsaw, Poland) Gomez, Enrique J. (Madrid, Spain) McCullagh, Paul (Ulster, UK) Hadjileontiadis, Leonthios (Thessaloniki, Greece) Miklavcic, Damijan (Ljubljana, Slovenia) Haex, Bart (Leuven, Belgium) Mizrahi, Joe (Haifa, Israel) Hahn, Eckhart (Erlingen, Germany) Mokwa, Wilfried (Aachen, Germany) Hammer, Joachim (Regensburg, Germany) Morgenstern, Ute (Dresden, Germany) Haueisen, Jens (Ilmenau, Germany) Müller-Krager, Carmen (Caracas, Venezuela) Hein, Hans-Joachim (Halle, Germany) Nagel, Joachim (Stuttgart, Germany) Herijgers, Paul (Leuven, Belgium) Niederer, Pieter (Zurich, Switzerland) Hesse, Christian (Nijmegen, The Netherlands) Niederlag, Wolfgang (Dresden, Germany) Hexamer, Martin (Bochum, Germany) Nunziata, Enrico (Torino, Italy) Hoelscher, Uvo (Münster, Germany) Nyssen, Marc (Brussels, Belgium) Hofmann, Ulrich (Lübeck, Germany) O’Brien, Fergal (Dublin, Ireland) Holcik, Jiri (Kladno, Czech Republic) Offenhäuser, Andreas (Jülich, Germany) Hozman, Jiri (Kladno, Czech Republic) Pallikarakis, Nicolas (Patras, Greece) Huang, Chun-Hsi (Connecticut, USA) Penzel, Thomas (Berlin, Germany) Husar, Peter (Ilmenau, Germany) Philips, Wilfried (Ghent, Belgium) Hutten, Helmut (Graz, Austria) Prendergast, Patrick J. (Dublin, Ireland) Hyttinen, Jari (Tampere, Finland) Puers, Bob (Leuven, Belgium) Igney, Claudia (Philips) Putzeys, Theo (Berchem, Belgium) Imhoff, Michael (Bochum, Germany) Rakhorst, Gerard (Groningen, The Netherlands) Jaeger, Marc (Karlsruhe, Germany) Reichenbach, Jürgen (Jena, Germany) James, Christopher J. (Southampton, U.K.) Ren, James (Liverpool, UK) Jämsä, Timo (Oulu, Finland) Robitzki, Andrea (Leipzig, Germany) Jaron, Dov (Philadelphia, USA) Rosahl, Steffen (Erfurt, Germany) Jobbàgy, Akos (Budapest, Hungary) Ruggeri, Alfredo (Padova, Italy) Jonkers, Ilse (Leuven, Belgium) Sansen, Willy (Leuven, Belgium) Kikuchi, Makoto (Saitama, Japan) Saranummi, Niilo (Tampere, Finland) Kim, Sun I. (Hanyang, Korea) Schacht, Etienne (Ghent, Belgium) Klee, Doris (Aachen, Germany) Schauer, Thomas (Berlin, Germany) Kolh, Philippe (Liège, Belgium) Scheunders, Paul (Antwerp, Belgium) Korb, Harald (Mannheim, Germany) Schmitz, Georg (Bochum, Germany) Kraft, Marc (Berlin, Germany) Schmitz, Klaus-Peter (Rostock, Germany) Krishnan, Shankhar M. (Boston, USA) Schrooten, Jan (Leuven, Belgium) Lackovic, Igor (Zagreb, Croatia) Secca, Màrio Forjaz (Lisboa, Portugal) Lahorte, Philippe (European Patent Office) Segers, Patrick (Ghent, Belgium) Le Beux, Pierre (Rennes, France) Siebes, Maria (Amsterdam, The Netherlands) Lee, Clive (Dublin, Ireland) Sijbers, Jan (Antwerp, Belgium) Lefèvre, Philippe (Louvain-La-Neuve, Belgium) Simanski, Olaf (Rostock, Germany) Lemahieu, Ignace (Ghent, Belgium) Slaaf, Dick (Maastricht, The Netherlands) Lemor, Robert (St. Ingbert, Germany) Staelens, Steven (Ghent, Belgium) Leonhardt, Steffen (Aachen, Germany) Stett, Alfred (Reutlingen, Germany) Liebert, Adam (Warsaw, Poland) Stieglitz, Thomas (Freiburg, Germany) Luypaert, Robert (Brussels, Belgium) Such, Olaf (Philips) Luyten, Jan (VITO, Belgium) Tabakov, Slavik (London, UK) Conference details XI

Thonnard, J.-L. (Brussels, Belgium) Vanderstraeten, Guy (Ghent, Belgium) Tonkovic, Stanko (Zagreb, Croatia) Vanrumste, Bart (Leuven, Belgium) Trahms, Lutz (Berlin, Germany) Veltink, Peter (Twente, The Netherlands) Urban, Gerald (Freiburg, Germany) Verbanck, Sylvia (Brussels, Belgium) Van Bortel, Luc (Ghent, Belgium) Verdonck, Pascal (Ghent, Belgium) Van Brussel, Hendrik (Leuven, Belgium) Verdonk, Peter (Ghent, Belgium) Van Buyten, Jean-Pierre (Vice President VAVP) Verdonk, René (Ghent, Belgium) Van de Voorde, Wim (Leuven, Belgium) Verellen, Dirk (Brussels, Belgium) Van Der Linden, A. (Antwerp, Belgium) Verkerke, Bart (Groningen, The Netherlands) Van der Perre, Georges (Leuven, Belgium) Vleugels, Arthur (Leuven, Belgium) Van Huffel, Sabine (Leuven, Belgium) Voigt, Herbert F. (Boston, USA) Van Humbeeck, Jan (Leuven, Belgium) Voss, Andreas (Jena, Germany) Van Leeuwen ,Peter (Bochum, Germany) Walter, Marian (Aachen, Germany) Van Lenthe, Harry (Leuven, Belgium) Werner, Jürgen (Bochum, Germany) Van Oosterwyck, Hans (Leuven, Begium) Wessel, Niels (Berlin, Germany) Van Zundert, Jan (President VAVP) Wildau, Hans-Jürgen (Berlin, Germany) Vandenberghe, Stefaan (Ghent, Belgium) Wojcicki, Jan (Warsaw, Poland) Vander Sloten, Jos (Leuven, Belgium) Wuyts, Floris (Antwerp, Leuven)

Content

Modern Concepts of Cardiovascular Analysis – Monitoring, Diagnosis, Risk Stratification, Prediction 1

Risk Stratification in Ischemic Heart Failure Patients with Linear and Nonlinear Methods of Heart Rate Variability Analysis...... 1 A. Voss, R. Schroeder, M. Vallverdú, H. Brunel, I. Cygankiewicz, R. Vázquez, A. Bayés de Luna and P. Caminal Biomagnetic risk stratification by QRS fragmentation in patients with Implanted Cardioverter Defibrillators...... 5 M. Goernig, D. DiPietroPaolo, J. Haueisen and S.E. Erné Beating Rate Variability Studies with Human Embryonic Stem Cell Derived Cardiomyocytes...... 8 F.E. Kapucu, M. Pekkanen-Mattila, V. Kujala, J. Viik, K. Aalto-Setelä, E. Kerkelä, J.M.A. Tanskanen and J. Hyttinen The method of assessment of chosen hemodynamic and electrophysiologic parameters in the healthy human subject circulation...... 12 K. Peczalski, D. Wojciechowski, P. Sionek, Z. Dunajski, T. Palko 2D Isochronal Correlation Method to Detect Pacing Capture during Ventricular Fibrillation...... 14 X. Ibáñez-Català, M.S. Guillem, A.M. Climent, F.J. Chorro, F. Pelechano, I. Trapero, E. Roses, A. Guill, A. Tormos, J. Millet Chaotic Phase Space Differential (CPSD) Algorithm for Real-Time Detection of VF, VT, and PVC ECG Signals...... 18 Chien-Sheng Liu, Yu-Chiun Lin, Yueh-Hsun Chuang, Tze-Chien Hsiao, Chii-Wann Lin Supervised ECG Delineation Using the Wavelet Transform and Hidden Markov Models...... 22 G. de Lannoy, B. Frenay, M. Verleysen and J. Delbeke Validating the Reliability of Five Ventricular Fibrillation Detecting Algorithms ...... 26 A.H. Ismail, M. Fries, R. Rossaint and S. Leonhardt Novel multichannel capacitive ECG-System for cardiac diagnostics beyond the standard-lead system...... 30 M. Oehler, M. Schilling and H.D. Esperer

On the Use of Independent Component Analysis in Biomedical Signal Processing

On Independent Component Analysis based on Spatial, Temporal and Spatio-temporal information in biomedical signals...... 34 C.J. James Extracting Event-Related Field Components Through Space-Time ICA: a Study of MEG Recordings from Children with ADHD and Controls...... 38 C. Demanuele, C. James, A. Capilla and E.J.S. Sonuga-Barke

Measurement, Signal Processing and Models for Human Movement and Posture Analysis: Measurements, Methods and Instrumentation

Gender differences in the control of the upper body accelerations during level walking ...... 43 C. Mazzà, M. Iosa, P. Picerno, F. Masala and A. Cappozzo Heart rate variability analysis during bicycle ergometer exercise ...... 47 Federica Censi, Daniele Bibbo and Silvia Conforto XIV Content

Color cues in Human Motion Analysis ...... 51 Ana Kuzmani Skelin, Damir Krstini and Vlasta Zanchi Transforming retinal velocity into 3D motor coordinates for pursuit eye movements ...... 55 G. Blohm, P. Daye and P. Lefevre Effectiveness of deep brain stimulation in subthalamic nucleus in Parkinson’s disease – a somatotopic organisation ...... 59 T. Heida, E.C. Wentink and J.A.G. Geelen The Median Point DTW Template to Classify Upper Limb Gestures at Different Speeds...... 63 R. Muscillo, M. Schmid and S. Conforto 2D Markerless Gait Analysis ...... 67 Michela Goffredo, John N. Carter and Mark S. Nixon Tremor control during movement of the upper limb using artificial neural networks...... 72 G. Severini, S. Conforto, I. Bernabucci, M. Schmid and T. D’Alessio Low-cost, Automated Assessment of Sit-To-Stand Movement in "Natural" Environments ...... 76 Sonya Allin and Alex Mihailidis Human Body Motions Classification...... 80 J. Havlik, J. Uhlir and Z. Horcik Parametric Representation of Hand Movement in Parkinson’s Disease ...... 85 R. Krupicka, Z. Szabo and P. Janda A wireless integrated system to evaluate efficiency indexes in real time during cycling...... 89 D. Bibbo, S. Conforto, I. Bernabucci, M. Schmid and T. D’Alessio Contactless head posture measurement...... 93 P. Janda, J. Hozman, M. Jirina, Z. Szabo and R. Krupicka Specialized glasses - projection displays for neurology investigation...... 97 Charfreitag J., Hozman J., Cerny R. Digital Wireless Craniocorpography with Sidelong Scanning by TV Fisheye Camera ...... 102 J. Hozman, P. Kutilek, Z. Szabo, R. Krupicka, M. Jirina, V. Zanchi and R. Cerny Calibration of a measurement system for the evaluation of efficiency indexes in bicycle training ...... 106 S. Conforto, S.A. Sciuto, D. Bibbo and A. Scorza Preliminary study on a remote system for diagnostic-therapeutic postural measurements ...... 110 S.A. Sciuto, IEEE Member and A. Scorza

FUSION – Future Environment for Gentle Liver Surgery Using Image-Guided Planning and Intra-Operative Navigation

Software Assistance for Planning of RF-Ablation and Oncological Resection in Liver Surgery ...... 114 S. Zidowitz, H. Bourquain, C. Hansen, C. Rieder, A. Weihusen, G. Prause and H.-O. Peitgen Ultrasound Navigated RFA of Liver Tumors ...... 118 S. Arnold, A. Schmitgen, G. Grunst, R. Kubitz, D. Reichelt, M. Cohnen LapAssistent - a laparoscopic liver surgery assistance system ...... 121 Volker Martens, Stefan Schlichting, Armin Besirevic, Markus Kleemann Content XV

The Living Human Project: Building the Musculoskeletal Physiome

The observation of human joint movement...... 126 A. Cappozzo

Biomedical Signal Processing

Estimation of speed distribution of particles moving in an optically turbid multiple scattering medium by decomposition of laser-Doppler spectrum...... 130 S. Wojtkiewicz, H. Rix, N. oek, R. Maniewski and A. Liebert A Novel Multivariate Analysis Method with Noise Reduction ...... 133 Shu-Hao Chang, Yu-Jen Chiou, Chun Yu, Chii-Wann Lin, Tzu-Chien Hsiao Iterative improvement of lineshape estimation...... 138 M.I. Osorio Garcia, D.M. Sima, J.-B. Poullet, D. van Ormondt, S. Van Huffel An Investigation of the use of a High Resolution ADC as a “Digital Biopotential Amplifier” ...... 142 D. Berry, F. Duignan and R. Hayes A portable data acquisition system for the measurement of impact attenuation material properties...... 148 David Eager and Chris Chapman Assessing Driver’s Hypovigilance from Biosignals...... 152 D. Sommer, M. Golz, U. Trutschel, D. Edwards Analyzing an sEMG signal using wavelets ...... 156 Y. Bastiaensen, T. Schaeps and J.P. Baeyens Role of Myelin in Synchronization and Rhythmicity of Visual Impulses ...... 160 S.M. Shushtarian Analyzing Magnetic Resonance Spectroscopic Signals with Macromolecular Contamination by the Morlet Wavelet...... 163 A. Suvichakorn, H. Ratiney, A. Bucur, S. Cavassila and J.-P. Antoine Robust and Adaptive Filtering of Multivariate Online-Monitoring Time Series ...... 167 M. Borowski, M. Imhoff, K. Schettlinger and U. Gather A novel synchronization measure for epileptic seizure detection based on Fourier series expansions ...... 171 H. Perko, M. Hartmann, K. Schindler and T. Kluge Investigating the Relationship between Breath Acoustics and FEV1 During Histamine Challenge...... 176 E. Chah, S. Glynn, M. Atiyeh, R.W. Costello and R.B. Reilly Spatio-Temporal Solutions in Inverse Electrocardiography ...... 180 Murat Onal, Yesim Serinagaoglu Genetic Algorithm Based Feature Selection Applied on Predicting Microsleep from Speech...... 184 J. Krajewski, M. Golz, D. Sommer and R. Wieland Automated detection of tonic seizures using 3-D accelerometry ...... 188 Tamara M.E. Nijsen, Ronald M. Aarts, Johan B.A.M. Arends, Pierre J.M. Cluitmans A Classification Attempt of COPD, ALI-ARDS and Normal Lungs of ventilated Patients through Compliance and Resistance over Time Waveform Discrimination...... 192 A. Tzavaras, B. Spyropoulos, E. Kokalis, A. Palaiologos, D. Georgopoulos, G. Prinianakis, M. Botsivaly and P.R. Weller Modified Matching Pursuit algorithm for application in sleep screening ...... 196 D. Sommermeyer, M. Schwaibold, B. Schöller, L. Grote and J. Hedner XVI Content

Wireless capsule endoscopic frame classification scheme based on higher order statistics of multi-scale texture descriptors...... 200 D. Barbosa, J. Ramos and C. Lima One-class support vector machine for joint variable selection and detection of postural balance degradation ...... 204 H. Amoud, H. Snoussi, D.J. Hewson and J. Duchêne The influence of treatment on linear and non-linear parameters of autonomic regulation in patients with acute schizophrenia...... 208 S. Schulz, K.J. Bär and A. Voss Intrinsic Mode Entropy for postural steadiness analysis...... 212 H. Amoud, H. Snoussi, D.J. Hewson and J. Duchêne Influence of different representations of the oscillometric index on automatic determination of the systolic and diastolic blood pressures...... 216 V. Jazbinsek, J. Luznik and Z. Trontelj Laser Doppler flowmetry signals: pointwise Hölder exponents of experimental signals from young healthy subjects and numerically simulated data...... 221 Benjamin Buard, Anne Humeau, David Rousseau, François Chapeau-Blondeau, and Pierre Abraham Exploring a physiological environment learning tool for encouraging continued deep relaxation...... 226 J. Condron, E. Coyle and A. de Paor Characterization of a bimodal electrocutaneous stimulation device...... 230 P. Steenbergen, J.R. Buitenweg, E.M. van der Heide and P.H. Veltink Identification of the electrohysterographic volume conductor by high-density electrodes...... 235 Chiara Rabotti, Massimo Mischi, Marco Gamba, Maartje Vinken, Guid Oei and Jan Bergmans Signal Separation in the Frequency Domain for Quantitative Ultrasound Measurements of Bone ...... 239 S. Dencks, R. Barkmann, C.-C. Glüer and G. Schmitz Consecutive Detection of Extreme Central Fatigue...... 243 D. Sommer, M. Golz and J. Krajewski Detection of Obstructive Sleep Apnea by Empirical Mode Decomposition on Tachogram...... 247 B. Mijovi, J. Corthout, S. Vandeput, M. Mendez, S. Cerutti, S. Van Huffel Empirical mode decomposition. Spectral properties in normal and pathological voices...... 252 M.E. Torres, G. Schlotthauer, H.L. Rufiner and M.C. Jackson-Menaldi Global and local inhomogeneity indices of lung ventilation based on electrical impedance tomography ...... 256 Z. Zhao, K. Möller, D. Steinmann, J. Guttmann Analysis of Intracardiac ECG Measured in the Coronary Sinus...... 260 C. Schilling, A. Luik, C. Schmitt and O. Dössel Rapid wheezing detection algorithm for real-time asthma diagnosis and personal health care...... 264 Chun Yu, Tzu-Chien Hsiao, Tzu-Hsiu Tsai, Shi-Ing Huang, Chii-Wann Lin Lung sound analysis to monitor lung recruitment...... 268 K. Möller, Z. Zhao, S. Schließmann, D. Schwenninger, S.J. Schumann, A. Kirschbaum, J. Guttmann Dual Kalman Filter based State-Parameter Estimation in Linear Lung Models ...... 272 E. Saatci and A. Akan Beat Pressure and Comparing it with Ascending Aorta Pressure in Normal and Abnormal Conditions...... 276 O. Ghasmelizadeh, M.R. Mirzaee, B. Firoozabadi, B. Sajadi, A. Zolfonoon Content XVII

Comparison of Ultrasonic Measurement and Numerical Simulation Results of the Flow through Vertebral Arteries...... 286 D. Obidowski, M. Mysior and K.St. Jozwik The Influence of Wall Deformation on Transmural Flow in Thoracic Aorta: Three-Dimensional Simulations...... 293 M. Dabagh, P. Jalali Non-invasive Vascular Ultrasound Strain Imaging: Different Arteries, Different Approaches...... 298 H.H.G. Hansen, R.G.P. Lopata, S. Holewijn, M. Truijers, and C.L. de Korte Photoplethysmogram Signal Conditioning by Monitoring of Oxygen Saturation and Diagnostic of Cardiovascular Diseases ...... 303 O. Abdallah, A. Piera Tarazona, T. Martínez Roca, H. Boutahir, K. Abo Alam, A. Bolz Choice of coordinate system for left ventricular FE-mesh generation...... 307 H.F. Choi, M. Wu, J. D’hooge, F.E. Rademakers and P. Claus Fetal ECG Extraction Using Multi-Layer Perceptron Neural Networks with Bayesian Approach ...... 311 S.Mojtaba Golzan, Farzaneh Hakimpourand Alireza Toolou Feature Selection for Brain-Computer Interface...... 318 N.S. Dias, P.M. Mendes and J.H. Correia Nature Inspired Concepts in Long-Term Electrocardiogram Clustering ...... 322 M. Bursa, L. Lhotska Evaluation of the MU Firing Strategies from Spectral Shape Analysis of sEMG Data ...... 326 M. Abi Hayla, S. Boudaoud and C. Marque Physiological Monitoring of Human Cognitive Processes...... 330 E. Vavrinsky, I. Brezina, P. Solarikova, V. Stopjakova, V. Tvarozek and L. Majer Is Detection of Different Anesthetic Levels Related to Nonlinearity of the Electroencephalogram?...... 335 D. Jordan, G. Stockmanns, E.F. Kochs and G. Schneider Combining HR-MAS and In Vivo MRI and MRSI Information for Robust Brain Tumor Recognition ...... 340 A. Croitor Sava, T. Laudadio, J.B. Poullet, D. Monleon, M.C. Martinez-Bisbal, B. Celda and S. Van Huffel Detection of ectopic beats in single channel electrocardiograms...... 344 A. Hekler, N. Kikillus and A. Bolz Application of Sequential Recognition of Patient Intent to the Bio-Prosthesis Hand Control – Experimental Investigations of Algorithms...... 348 A. Wolczowski, D. Davies and M. Kurzynski EEG Coherence as Measure of Depressive Disorder...... 353 Anna Suhhova, Maie Bachmann, Kaire Aadamsoo, Ülle Võhma, Jaanus Lass and Hiie Hinrikus Spectral Analysis of Overnight Pulse Oximetry Recordings in Sleep Studies...... 356 Birgit Schultheiß, Agnieszka Jozefiak-Wesolowska, Nikolaus Böhning, Eckhard Schmittendorf Changes in connectivity patterns in the kainate model of epilepsy...... 360 P. van Mierlo, S. Assecondi, S. Staelens, P. Boon and I. Lemahieu Detection of Foveation Windows and Analysis of Foveation Sequences in Congenital Nystagmus ...... 364 Giulio Pasquariello, Mario Cesarelli, Paolo Bifulco, Antonio Fratini, Antonio La Gatta, Domenico Boccuzzi Relationship between Eye Movement and Facilitation of Perceptual Filling-in ...... 368 M. Yokota and Y. Yokota Modeling the macromolecular background in Nuclear Magnetic Resonance spectroscopic signals ...... 372 D.M. Sima, A.M. Rodríguez Díaz and S. Van Huffel XVIII Content

Real-time BSPM processing system ...... 377 J. Muzik, K. Hana Review on biostatistical results associated with the application of signal-processing-based scores for acute myocardial infarction (AMI) clinics...... 381 S.A.F. Amorim, J.B. Destro-Filho, L.O. Resende, M.A. Colantoni, E.S. Resende A Principal Component Regression Approach for Estimation of Ventricular Repolarization Characteristics...... 385 J.A. Lipponen, M.P. Tarvainen, T. Laitinen, T. Lyyra-Laitinen and P.A. Karjalainen Diagnosis of Ischemic Heart Disease with Cardiogoniometry – Linear discriminant analysis versus Support Vector Machines ...... 389 A. Seeck, A. Garde, M. Schuepbach, B. Giraldo, E. Sanz, T. Huebner, P. Caminal, A. Voss Enhancement of a QRS detection algorithm based on the first derivative, using techniques of a QRS detector algorithm based on non-linear transformations ...... 393 C. Vidal, P. Charnay and P. Arce Using the wavelet packet transform in automatic sleep analysis...... 397 Beena Ahmed, Reza Tafreshi Proposal of Feature Extraction from Wavelet Packets Decomposition of QRS Complex for Normal and Ventricular ECG Beats Classification...... 402 Michal Huptych, Lenka Lhotská

Biomedical Imaging and Image Processing

Biomedical Image Segmentation Based on Morphological Spectra ...... 406 J.L. Kulikowski and M. Przytulska Magnetic Resonance Imaging in Inhomogeneous Magnetic Fields with Noisy Signal ...... 410 V.E. Arpnar, B.M. Eyübolu Combining EEG signals and MRI images for brain mapping using interpolation techniques; a comparative study...... 414 Pooryaghooti M.H., Golzan S.M., Hakimpour F., Karimi M. Detection of Basal Nuclei on Magnetic Resonance Images using Support Vector Machines...... 421 R. Villegas, A. Bosnjak, R. Chumbimuni, E. Flores, C. López and G. Montilla Analysis of digital radiographic equipments with development of specific phantoms and software ...... 425 P. Mayo, F. Rodenas, B. Marín, J.M. Campayo and G. Verdú Nonlinear Diffusion Filtering of Single-Trial Matrix Representations of Auditory Brainstem Responses...... 429 I. Mustaffa, F.I. Corona-Strauss, C. Trenado and D.J. Strauss A Multi-component similarity measure for improved robustness of non-rigid registration of combined FDG PET-CT head and neck images...... 433 Y. Papastavrou, D. Cash, D. Hawkes and B. Hutton Deconvolution of freehand 3d ultrasound data using improved reconstruction techniques in consideration of ultrasound point spread functions ...... 436 H.J. Hewener, R.M. Lemor Modeling of ultrasound propagation through contrast agents...... 440 J.J.F.A.H. Grootens, M. Mischi, M. Böhmer, H.H.M. Korsten, R.M. Aarts Evaluation of Simplex Codes for Photoacoustic Coded Excitation ...... 444 M.P. Mienkina, A. Eder, C.-S. Friedrich, N.C. Gerhardt, M.R. Hofmann and G. Schmitz Content XIX

Developing a high-resolution photoacoustic microscopy platform ...... 448 W. Bost, F. Stracke, M. Fournelle and R. Lemor Investigation of changes in acoustic properties resulting from contrast material in through-transmission ultrasonic imaging ...... 452 T. Rothstein, D. Gaitini, Z. Gallimidi, H. Azhari Transcranial sonography as early indicator for genetic Parkinson’s disease ...... 456 Christian Kier, Günter Seidel, Norbert Brüggemann, Johann Hagenah, Christine Klein, Til Aach and Alfred Mertins Comparison of Imaging Modalities for Quantification of Cyanoacrylate Microbubble Concentration...... 460 M. Siepmann, G. Schmitz Ranking of color space components for detection of blood vessels in eye fundus images ...... 464 M. Patasius, V. Marozas, D. Jegelevicius, A. Lukoševiius Detection of the Optic Disc in Images of the Retina Using Gabor Filters and Phase Portrait Analysis ...... 468 Rangaraj M. Rangayyan, Xiaolu Zhu, and Fábio J. Ayres A Markov Random Field Approach to Outline Lesions in Fundus Images ...... 472 E. Grisan and A. Ruggeri Realtime Temperature Control towards Gentle Photocoagulation of the Retina...... 476 R. Brinkmann, K. Schlott, L. Baessler, K. Herrmann, W. Xia, M. Bever, R. Birngruber Estimation of Real-Time Red Blood Cell Velocity in Conjunctival Vessels using a Modified Dynamic-Time-Warping Approach ...... 480 E. Grisan, A. Tiso and A. Ruggeri Functional Optical Imaging of a tissue based on Diffuse Reflectance with Fibre Spectrometer...... 484 Shanthi Princeand S. Malarvizhi Elimination of clavicle shadows to help automatic lung nodule detection on chest radiographs ...... 488 G. Simkó, G. Orbán, P. Máday, G. Horváth A Novel Approach for Reducing Dental Filling Artifact in CT-Based Attenuation Correction of PET Data ...... 492 M. Abdoli, M.R. Ay, A. Ahmadian, N. Sahba and H. Zaidi Comparative Assessment of Different Energy Mapping Approaches in CT Based Attenuation Correction: a Patient Study...... 496 M. Shirmohammad, M.R. Ay, S. Sarkar, A. Rahmim, H. Zaidi Optimization of Yttrium-90 Bremsstrahlung Imaging with Monte Carlo Simulations ...... 500 E. Rault, S. Vandenberghe, S. Staelens and I. Lemahieu Sinogram-Based Motion Detection in Transmission Computed Tomography ...... 505 S. Ens, J. Müller, B. Kratz and T.M. Buzug A Comparison of MTT Calculation Techniques in MRI Brain Perfusion Imaging ...... 509 J. Ruminski Reduction of Intravenous Contrast Related Artifacts in CT-Based Attenuation Corrected PET Images ...... 513 M.R. Ay, J.H. Bidgholi, P. Ghafarian and H. Zaidi Detection of characteristic texture parameters in breast MRI...... 517 K.K. Holli, A.-L. Lääperi, L. Harrison, S. Soimakallio, P. Dastidar, H.J. Eskola Numerical evaluation and comparison of instantaneous anatomical knee joint axes and orthotic joint axes using MRI data under weight-bearing condition...... 522 Annegret Niesche, Martin Tettke, David Hochmann and Marc Kraft XX Content

A new method for quantitative evaluation of target volume variations in radiotherapy planning...... 526 F. Gaya, B. Rodriguez-Vila, F. del Pozo, F. Garcia-Vicente and E.J. Gomez Computer Aided Monitoring of Bone Quality and New Bone Formation upon Distractive Maxillary Expansion based on Pre- and Post-Surgical CT-Data...... 530 C. Kober, C. Landes, A. Preiss, Y. Lu, P. Young and R. Sader Automatic Landmark Detection on Epicondyles of Distal Femur in X-Ray Images...... 533 B. Heidari, F. Madeh Khaksar and D. FitzPatrick A multichannel system for real-time optoacoustics and its suitability for molecular imaging ...... 537 M. Fournelle, K. Maass, H. Hewener, C. Günther, H. Fonfara, H.-J. Welsch, R. Lemor An Automated System for Full Angle Spatial Compounding in Ultrasound Breast Imaging ...... 541 Ch. Hansen, N. Hüttebräuker, M. Hollenhorst, A. Schasse, L. Heuser, G. Schulte-Altedorneburg and H. Ermert AM-FM Representations for the Characterization of Carotid Plaque Ultrasound Images...... 546 C.I. Christodoulou, C.S. Pattichis, V. Murray, M.S. Pattichis, A. Nicolaides Segmentation of 3D Echocardiographic Images using Deformable Simplex Meshes and Adaptive Filtering ...... 550 M.M. Nillesen, R.G.P. Lopata, I.H. Gerrits, L. Kapusta, H.J. Huisman, J.M. Thijssen, C.L. de Korte Geometric regularization improves 2D myocardial motion estimates in the mouse: an in-silico study...... 555 F. Kremer, H.F. Choi, S. Langeland, E. D’Agostino, P. Claus and J. D’hooge Experimental setup with dual chamber cardiac phantom for ultrasonic elastography ...... 559 B. Lesniak-Plewinska, M. Kowalski, S. Cygan, E. Kowalik and K. Kaluzynski Phase-resolved Doppler Fourier Domain Optical Coherence Tomography in the in vivo mouse model...... 563 J. Walther, G. Mueller, M. Cuevas, H. Morawietz and E. Koch Pseudo Automatic camera extrinsic estimation using 3D Hough Transform ...... 567 Wouter Belmans, Tim Schaeps and Bart Jansen A novel intrinsically calibrated method to measure intracellular Ca2+ with ultimate detection sensitivity utilizing confocal Fluorescence Correlation Spectroscopy (cFCS)...... 571 Norbert Opitz and Stephan Gude An Efficient Airway Tree Segmentation Method Robust to Leakage Based on Shape Feature Optimization ...... 575 F. Youefi Rizi, A. Ahmadian, J. Alirezaie, N. Rezaie, M. Abdoli Vessel tree extraction: Combination of a region competition based active contour model with a tubular active contour model ...... 579 Y. Shang, R. Deklerck, E. Nyssen, A. Markova and X. Yang Graph-based Tracking Method for Aortic Thrombus Segmentation...... 584 J. Egger, T. O’Donnell, C. Hopfgartner and B. Freisleben Fully automatic assessment of carotid artery curvature and diameter with non-invasive ultrasound...... 588 Alessandro C. Rossi, Peter J. Brands and Arnold P.G. Hoeks Liver and Lesion Segmentation Algorithm for Contrast Enhanced CT Images...... 592 A. Markova, F. Temmermans, R. Deklerck, E. Nyssen, P. Clerinx, F. De Munck and J. DeMey Anatomical Models for Computer Assisted Surgery Using Support Vector Machine ...... 596 A. Bosnjak, G. Montilla, R. Villegas, I. Jara MRI-based 3D-Modelling of Gleno-humeral Joint Deformities for Functional Surgical Planning ...... 600 G. Al Hares, J. Bahm, B. Wein and K. Radermacher Extending Mammographic Microcalcification Detection Method to Cluster Characterization ...... 604 B. Pataki, L. Lasztovicza Content XXI

Medical feature matching and model extraction from MRI/CT based on the Invariant Generalized Hough/Radon Transform...... 608 D. Hlindzich, R. Maenner Image Segmentation of Cell Nuclei based on Classification in the Color Space ...... 613 T. Wittenberg, F. Becher, M. Hensel and D.G. Steckhan Volume Estimation of Pathology Zones in 3D Medical Images...... 617 K. Krechetova, A. Glazs Estimation of blurring of optic nerve disc margin...... 621 M. Patašius, V. Marozas, D. Jegeleviius, D. Daukantait, A. Lukoševiius Robust Data Driven Modeling of Time Intensity Curves...... 625 A. Maciak, A. Kronfeld, P. Stoeter, T. Vomweg, D. Mayer, G. Seidel, K. Meyer-Wiethe An optimization framework for classifier learning from image data for computer-assisted diagnosis ...... 629 J. Mennicke, C. Münzenmayer, T. Wittenberg, and U. Schmid Classification of alveolar microscopy videos with respect to alveolar stability...... 633 D. Schwenninger, K. Moeller, H. Liu and J. Guttmann Automated Detection of Cell Nuclei in PAP stained cervical smear images using Fuzzy Clustering...... 637 M.E. Plissiti, E.E. Tripoliti, A. Charchanti, O. Krikoni and D.I. Fotiadis Analysis of Capsule Endoscopy Images Related to Gastric Ulcer Using Bidimensional Empirical Mode Decomposition ...... 642 Alexandra Tsiligiri and Leontios J. Hadjileontiadis Motion compensated iterative reconstruction of a cardiac region of interest for CT...... 646 A.A. Isola, A. Ziegler, T. Köhler, U. van Stevendaal, D. Schäfer, W.J. Niessen and M. Grass An Image Inpainting Based Surrogate Data Strategy for Metal Artifact Reduction in CT Images ...... 651 M. Oehler and T.M. Buzug Rodent Imaging with Helical μCBCT...... 655 D. Soimu, Z. Kamarianakis and N. Pallikarakis Microcalcification Detection using Digital Tomosynthesis, Dual Energy Mammography and Cone Beam Computed Tomography: A Comparative Study...... 660 Z. Kamarianakis, D. Soimu, K. Bliznakova, N. Pallikarakis Non-Minimum Phase Iterative Deconvolution of Ultrasound Images ...... 664 N. Testoni, L. De Marchi, N. Speciale and G. Masetti Dynamic Visualization of the Human Orbit for Functional Diagnostics in Ophthalmology, Cranio-maxillofacial Surgery, and Neurosurgery ...... 669 C. Kober, B.-I. Berg, C. Kunz, E.W. Radü, K. Scheffler, H.-F. Zeilhofer, C. Buitrago-Téllez and A. Palmowski-Wolfe A Communication Term for the Combined Registration and Segmentation...... 673 Konstantin Ens, Jens von Berg and Bernd Fischer Elastic Registration of Optical Images showing Heart Muscle Contraction ...... 676 M. Janich, G. Seemann, J. Thiele and O. Dössel Automation of the preoperative image processing steps for ultrasound based navigation...... 680 C. Dekomien, S. Winter Elastic Registration of Functional MRI Data to Sensorimotor Cortex...... 684 T. Ball, I. Mutschler, D. Jäger, M. Otte, A. Schulze-Bonhage, J. Hennig, O. Speckand A. Schreiber Enhanced Visualization of Ultrasound Volumes for Diagnostic and Therapeutic Purposes...... 689 U. von Jan, D. Sandkühler, M. Rauberger, H.K. Matthies and H.M. Overhoff XXII Content

Compensation of Cardiac Motion in Angiographic Sequences for the Assessment of Myocardial Perfusion ...... 693 M. Erbacher, G. Korosoglou, R. Floca and H. Dickhaus 3D Cardiac Strain Imaging using a Novel Tracking Method ...... 697 R.G.P. Lopata, M.M. Nillesen, I.H. Gerrits, H.H.G. Hansen, L. Kapusta, J.M. Thijssen and C.L. de Korte SWI Brain Vessel Change Coincident with fMRI Activation...... 701 Mario Forjaz Secca, Michael Noseworthy, Henrique Fernandes and Adrain Koziak A Subspace Wiener Filtering Approach for Extracting Task-Related Brain Activity from Multi-Echo fMRI Data...... 705 C.W. Hesse, P.F. Buur and D.G. Norris An Elasticity Penalty: Mixing FEM and Nonrigid Registration ...... 709 D. Loeckx, L. Roose, F. Maes, D. Vandermeulen and P. Suetens Evaluation of the biodistribution of In-111 labeled cationic Liposome in mice using multipinhole SPECT Technique ...... 713 S.O. Viehoever, D. Buchholz, H.W. Mueller, O. Gottschalk, A. Wirrwar Multimodal Medical Case Retrieval using Dezert-Smarandache Theory with A Priori Knowledge...... 716 G. Quellec, M. Lamard, G. Cazuguel, B. Cochener and C. Roux Noise properties of the 3-electrode skin admittance measuring circuit ...... 720 S. Grimnes, Ø.G. Martinsen and C. Tronstad Thermal Imaging of Skin Temperature Distribution During and After Cooling: In-Vitro Experiments ...... 723 M. Kaczmarek, J. Ruminski Magnetic Resonance Electrical Impedance Tomography For Anisotropic Conductivity Imaging...... 728 E. Deirmenci and B.M. Eyübolu Electro-Magnetic Impedance Tomography – a sensitivity analysis ...... 732 A. Janczulewicz, A. Bujnowski and J. Wtorek A feasibility study on the delectability of Edema using Magnetic Induction Tomography using an Analytical Model...... 736 B. Dekdouk, M.H. Pham, D.W. Armitage, C. Ktistis, M. Zolgharni and A.J. Peyton Ventilatory Pattern monitoring by Electrical Impedance Tomography (EIT) in Chronic Obstructive Pulmonary Disease (COPD) patients ...... 740 Marco Balleza, Teresa Feixas, Nuria Calaf, Mercedes González, Daniel Antón, Pere J. Riu and Pere Casan A Magnetic Induction Tomography system with sub-millidegree phase noise and high long-term phase stability .... 744 H.C. Wee, S. Watson, R. Patz, H. Griffiths, R.J. Williams A method for increasing the phase-measurement stability of Magnetic Induction Tomography systems ...... 748 S. Watson, H.C. Wee, R. Patz, R.J. Williams, H. Griffiths Reduction of low-frequency noise in magnetic induction tomography systems...... 752 H. Scharfetter, S. Issa Regional Image Reconstruction with Optimum Currents for MREIT – Evaluation on Shepp-Logan Conductivity Phantom ...... 756 B. Murat Eyübolu, Adnan Köksal and Haluk Altunel A Breast Surface Estimation Algorithm for UWB Microwave Imaging ...... 760 M. Helbig, C. Geyer, M. Hein, I. Hilger, U. Schwarz, J. Sachs Automatic Lung Segmentation of Helical-CT Scans in Experimental Induced Lung Injury...... 764 L.M. Cuevas, P.M. Spieth, A.R. Carvalho, M.G. de Abreu and E. Koch Content XXIII

Identification of coronary collaterals in imaging cryomicrotome datasets ...... 768 J.P.H.M. van den Wijngaard, P. van Horssen, R.D. ter Wee, M. Siebes, H. Schulten, M.J. Post, J.A.E. Spaan Improved regional myocardial perfusion measurement by means of an imaging cryomicrotome ...... 771 Pepijn van Horssen, Jeroen P.H.M. van den Wijngaard, Maria Siebes, Jos A.E. Spaan Dose Distribution in Pediatric CT Head Examination: Phantom Study ...... 775 R. Gotanda, T. Katsuda, T. Gotanda, A. Tabuchi, H. Yatake and Y. Takeda Measurement of Half-Value Layer for QA and QC: Simple Method Using Radiochromic Film Density ...... 780 T. Gotanda, T. Katsuda, R. Gotanda, A. Tabuchi, K. Yamamoto, T. Kuwano, H. Yatake and Y. Takeda Towards automatic detection of movement during sleep in pediatric patients with epilepsy by means of video recordings and the optical flow algorithm...... 784 K. Cuppens, L. Lagae and B. Vanrumste Accuracy improvement of nuclear position extraction from hepatic histopathologic images ...... 790 M. Takahashi, H. Takayama, K. Oguruma and M. Nakano Extraction of fibers and nuclei of hepatic histopathologic specimen stained with silver and HE ...... 795 T. Kitani, M. Takahashi and M. Nakano Alignment Pixel-to-Pixel for Mammography Obtained by Dual Energy ...... 799 I.T. Costa, H.J.Q. Oliveira Reconstruction of phase images for GRAPPA accelerated Magnetic Resonance Imaging...... 803 C. Ros, S. Witoszynskyj, K.-H. Herrmann and J.R. Reichenbach Probabilistic Assignment of Brain Responses to the Human Amygdala and its Subregions using High Resolution Functional MRI...... 807 Isabella Mutschler, Birgit Wieckhorst, Andreas Schulze-Bonhage, Erich Seifritz, Jürgen Hennig, Oliver Speck, and Tonio Ball Velocity Analysis by Using Doppler Fourier Domain Optical Coherence Tomography with Variable Reference Length...... 811 D. Hammer, J. Walther, M. Cuevas and E. Koch Transverse and oblique motion effects in Fourier Domain Optical Coherence Tomography...... 816 J. Walther, M. Cuevas and E. Koch Enhancement of alveolar videos using scattered light for illumination ...... 821 D. Schwenninger, K. Moeller, M. Schneider and J. Guttmann Applications of Microwave Radiometry in Diagnostic Suspicion of Mammary Pathology ...... 825 L. Mustata, O. Baltag Performance of Semiconductor Gamma-Camera System with CdZnTe Detector...... 829 K. Ogawa, T. Ishikawa, K. Shuto, N. Motomura and H. Kobayashi Ultra-high Resolution SPECT with CdTe Detectors ...... 832 Naoka Ohmura, Koichi Ogawa SPECT imaging with a semiconductor detector and a diverging collimator ...... 836 Mizuho Fukizawa andKoichi Ogawa Sonographic analysis of hyoid bone movement during swallowing ...... 840 Koichi Yabunaka, Mutsumi Ohue, Tsutomu Hashimoto, Toshizo Katsuda, Kenyu Yamamoto and Shigeru Sanada Computer-aided ultrasound diagnosis of hepatic steatosis ...... 843 Gert Weijers, Johan. M. Thijssen, Alexander Starke, Alois Haudum, Kathrin Herzog, Jürgen Rehage, and Chris L. De Korte In vivo determination of the human crystalline lens shape with clinically established measurement methods ...... 848 H. Martin, O. Stachs, R. Guthoff, T. Terwee, N. Hosten and K.-P. Schmitz XXIV Content

Continuous wave Doppler ultrasound measurement of micro-vibrations induced by a focused acoustic radiation force ...... 852 T.Z. Pavan, A.L. Baggio, A.A.O. Carneiro Estimation of Carotid Stiffness Using Ultrasonic Dynamic Images for Evaluating the Degree of Arteriosclerosis...... 856 Y. Yokota, R. Taniguchi, Y. Kawamura, F. Nogata, H. Morita, Y. Uno CT-MAR Reconstruction Using Non-Uniform Fourier Transform...... 861 B. Kratz, T. Knopp, M. Oehler, S. Ens, T.M. Buzug Personalized Ambient Monitoring: Accelerometry for Activity Level Classification ...... 866 J.D. Amor and C.J. James

Healthcare Information Systems

Engineering for Health in OP 2000...... 871 G. Graschew, T.A. Roelofs, S. Rakowsky and P.M. Schlag Wireless microsensors system for monitoring breathing activity...... 875 N. André, P. Gerard, P. Drochmans, T. Kezai, S. Druart, L. Moreno-Hagelsieb, L. Francis, D. Flandre and J.-P. Raskin Identity Management to Support Access Control in E-Health Systems ...... 880 Xu Chen, Damon Berry and William Grimson Building Trust on Body Sensor Network Signals...... 887 Annarita Giani, Ville-Pekka Seppä, Jari Hyttinen and Ruzena Bajcsy Effects of UV Radiation on the Airborne Particles in the Operating Room...... 891 Y. Ülgen and I. Tezer Soluble Gas Tight Capsules for use in Surgical Quality Testing...... 895 J.B. Vorstius, G.A. Thomson and A.P. Slade Optimization of Ultrasonic Tool Performance in Surgery...... 899 Yongqiang Qiu, Zhihong Huang, Alan Slade and Gareth Thomson A parallel kinematic mechanism for highly flexible laparoscopic instruments...... 903 A. Röse, H.F. Schlaak A Smart Ultrasonic Cutting System for Surgery ...... 907 Anila Thampy, Zhihong Huang, Alan Slade and Victor Fernandez Simultaneous Stereo-Optical Navigation of Medical Instruments for Brachytherapy...... 911 K. Berthold, D. Richter, F. Schneider and G. Straßmann The impact of electrosurgical heat on optical force feedback sensors ...... 914 J.A.C. Heijmans, M.P.H. Vleugels, E. Tabak, T.v.d. Dool, M.P. Oderwald Classification and Data Mining for Hysteroscopy Imaging in Gynaecology...... 918 M.S. Neofytou, A. Loizou, V. Tanos, M.S. Pattichis, C.S. Pattichis Video-endoscopic image analysis for 3D reconstruction of the surgical scene...... 923 A.M. Cano, P. Sánchez-González, F.M. Sánchez-Margallo, I. OropesaF. del Pozo and E.J. Gómez Development of graphical user interface to control remote probe by reflecting contact force on body surface for tele-echography system ...... 927 K. Masuda, T. Horiguchi, K. Ookomori, H. Watanabe, K. Ozawa, T. Yoshinaga and Y. Aoki An endoscopic laser navigation system for computer assisted surgery...... 932 B. Kosmecki, D. Mucha, M. Khan and T. Krueger Content XXV

Comparison of optical CT imaging versus NMR imaging for nPAG gel dosimetry...... 936 J. Vandecasteele and Y. De Deene Application of a surgical navigation system for zygoma implant surgery...... 940 Chen Xiaojun, Wu Yiqun and Wang Chengtao Individual bone implant modeling using planned resection lines for facial and cranial tumor resection ...... 944 A. Rose, M. Klein and T. Krueger A feasibility study on chronic wounds of laser Doppler perfusion imaging during Topical Negative Pressure therapy...... 948 S.H. Aarnink, M.D.I. Lansbergen, W. Steenbergen Automated Inspection System of Stent ...... 952 Issa Ibraheem, Alfred Binder An intrahepatic electromagnetic localizer...... 958 R. Maestle, D. Mucha, B. Kosmecki and T. Krueger Computerized Interpretation of Cardiotocographs Using Kubli Score...... 962 B.N. Krupa, F.M. Hasan, M.A. Mohd. Ali and E. Zahedi Unrotating images in laparoscopy with an application for 30° laparoscopes...... 966 M. Moll, T. Koninckx, L.J. Van Gool and P.R. Koninckx Teleimage: An Integrated Approach for Secure and Web-based Exchange of Medical Images and Reports ...... 970 T. Kurmann, D. Slamanig, C. Stingl and K. Roessl The Degree of Privacy in Web-based Electronic Health Records ...... 974 D. Slamanig and C. Stingl Electronic physiotherapy registry: towards structured physiotherapy records ...... 978 R. Buyl, M. Nyssen A Low Power Wireless Personal Area Network for Telemedicine...... 982 Cr. Rotariu, H. Costin, D. Arotaritei and G. Constantinescu Towards an e-Learning and Telemedicine Network for Better Quality of Patient Care ...... 986 Vincenzo Lanza, M. Ignazia Cascio and Chun-Hsi Huang Electronic Report Generation Web Service evaluated within a Telemedicine System...... 994 I. Martínez-Sarriegui, M.E. Hernando, F.J. Brito, G. García-Sáez, J. Molero, M. Rigla, E. Brugués, A. de Leiva, E.J. Gómez Efficient database and web service design for confidential patient data in the TEMONICS project...... 998 H. Meier, I. Alich, H. Flick and B. Kotterba TELEMON – A Complex System for Real Time Telemonitoring of Chronic Patients and Elderly People...... 1002 Hariton Costin, Vlad Cehan, Cristian Rotariu, Octavia Morancea, Victor Felea, Ioana Alexa, Gladiola Andruseac, Ciprian Costin Mobile Devices for e-Services in Home Care ...... 1006 P. Aubrecht, L. Lhotska, J. Dolezel and J. Dolezal Personalised Ambient Monitoring (PAM) of the mentally ill ...... 1010 C.J. James, J. Crowe, E. Magill, S.C. Brailsford, J. Amor, P. Prociow, J. Blum and S. Mohiuddin Method for the detection of life-threatening conditions in unconscious casualties...... 1014 M. Jaeger, Y. Jin, T. Oezkan, R. Jaeger and A. Bolz A Population Prospect for Future Health Care Models based on a System Dynamics Model ...... 1018 J. Schröttner, E. König and N. Leitgeb Kubios HRV – A Software for Advanced Heart Rate Variability Analysis ...... 1022 M.P. Tarvainen, J.-P. Niskanen, J.A. Lipponen, P.O. Ranta-aho and P.A. Karjalainen XXVI Content

Implementation of an Open Telenephrology Platform to Support Home Monitoring...... 1026 F. Seoane, M.A. Valero, A. García-Perez and P. Gallar An analysis of PLC noise level for risk management of medical use RFID system ...... 1030 R. Hosaka Intelligent Synchronized Magnifying Glasses for Assisting Reading of Temporal Mammograms...... 1034 F. Temmermans, R. Deklerck, M. Suliga, C. Breucq, G. Behiels and P. Dewaele A platform for physiological signals including an intelligent stethoscope ...... 1038 L. Rattfalt, C. Ahlstrom, M. Eneling, B. Ragnemalm, P. Hult, M. Lindén and P. Ask Energy requirements of mobile phones and sensor technologies in mobile health applications...... 1042 J. Kreuzer, R. Diemer and T. Huber

Bioinstrumentation and Medical Devices

Approach to Quantitative Detection of CD146 with a Label-free Protein Biosensor Based on Imaging Ellipsometry...... 1046 Yu Niu, Ying Zhang, Xiyun Yan, Gang Jin A Compact Imaging Ellipsometer for Label-free Biosensor...... 1050 Yidan Luo, Gang Jin Towards Forehead Reflectance Photoplethysmography to Aid Delivery Room Resuscitation in Newborns...... 1053 M.R. Grubb, B.R. Hayes-Gill, J.A. Crowe, D. Sharkey, N. Marlow, and N.J. Miles Low-cost miniaturized UV photosensor for direct measurement of DNA concentration within a closed tube container ...... 1057 O. Bulteel, P. Dupuis, S. Jeumont, L.M. Irenge, J. Ambroise, B. Macq, J.-L. Gala and D. Flandre Comparative Assessment of Rotating Slat and Parallel Hole Collimator Performance in GE DST-Xli Gamma Camera: A Monte Carlo Study...... 1062 N. Dehestani, S. Sarkar, M.R. Ay, M. Sadeghiand M. Shafaei Essential Design Considerations for Wireless Multi-Channel Photoplethysmography System ...... 1066 A.Y. Kadhim, M.A.M. Ali and E. Zahedi Contact-less human vital sign monitoring with a 12 channel synchronous parallel processing magnetic impedance measurement system ...... 1070 F. Liebold, M. Hamsch and C.H. Igney An CMT reconstruction algorithm for detection of objects buried in a half-space...... 1074 A. Janczulewicz, J. Wtorek and A. Bujnowski The concept of transfer impedance in bioimpedance measurements...... 1078 Ø.G. Martinsen and S. Grimnes Evaluation of an automated PEEP controller in mechanical ventilation support ...... 1080 J. Arntz, D. Gottlieb, S. Lozano, J. Guttmann, K. Möller Fast Electrical Impedance Spectroscopy for Moving Tissue Characterization Using Bilateral QuasiLogarithmic Multisine Bursts Signals ...... 1084 B. Sanchez and R. Bragos Assessment of Breathing Parameters during Running with aWearable Bioimpedance Device ...... 1088 V.-P. Seppä, J. Väisänen, O. Lahtinen and J. Hyttinen QCM Sensor Frequency Responses and MAC Values Comparison of Different Anesthetics used in Inhalation Anesthesia...... 1092 H.M. Saraolu and B. Krankabe Content XXVII

Online-Classification of Capnographic Curves Using Artificial Neural Networks ...... 1096 Marcus Bleil, Alexander Opp, Roland Linder, Soehnke Boye, Hartmut Gehring, Ulrich G. Hofmann Evaluation of Conventional and Non-Conventional Pulse Oximeter...... 1100 M.A. Haleem, M.Z. Haque, F. Azhar and M.A. Muqeet Volumetric Registration Method in Lung Tumour Discrimination...... 1104 João Cancela, José Silvestre Silva and Luísa Teixeira Towards an ARM based low cost and mobile biomedical device test bed for improved multi-channel pulmonary diagnosis...... 1108 Z. Çatmaka, .H. Köse, O. Toker, H.R. Öz

An evaluation of end-tidal CO2 change following alterations in ventilation frequency...... 1113 M.C. Jensen, S. Lozano, D. Gottlieb, J. Guttmann, K. Möller Development of automatic respiration monitoring for home-care patients of respiratory diseases with therapeutic aids ...... 1117 M. Okubo, Y. Imai, T. Ishikawa, T. Hayasaka, S. Ueno and T. Yamaguchi Computer-Assisted Decision Support in the Sleep Apnea-Hypopnea Syndrome ...... 1121 D. Álvarez-Estévez and V. Moret-Bonillo A new calibration method with support vector machines for pulse oximetry...... 1125 M. Ogawa, Y. Yamakoshi, M. Nogawa, T. Yamakoshi, K. Motoi, S. Tanakaand K. Yamakoshi Hardware-in-the-Loop Testing for closed-loop Brain Stimulators ...... 1128 S.M. Vogt, M. Klostermann, A. Kundu, S. Andruschenko, and U.G. Hofmann A Virtual Instrument for Bio-impedance Measurement in Oral Cavity ...... 1133 M. Kaštelan, S. Vlahini and I. Richter Magnetic Marker Monitoring Using a Permanent Magnetic Sphere Oriented by a Rotating Magnetic Field...... 1137 W. Andrä, M.E. Bellemann, M. Brand, J. Haueisen, H. Lausch, P. Saupe and C. Werner An Improved Local Pressurization-Cuff Technique for Non-invasive Digital Arterial Pressure by the Volume-Compensation Method: Its Performance and Evaluation of Accuracy ...... 1141 A. Ikarashi, M. Nogawa, T. Yamakoshi, S. Tanaka and K. Yamakoshi A Novel Electrophysiological Measurement System to Study Rapidly Paced Animal Hearts...... 1145 R. Arnold, T. Wiener, T. Thurner and E. Hofer Measurements of pressure distribution by the tongue of infants on an artificial nipple...... 1149 T. Niikawa, R. Kawachi, K. Minato and Y. Takada A novel multielectrode for epicardial recording with temperature control based in Peltier cells...... 1153 Guill A., Roses E., Ibáñez-Català X., Tormos A., Guillem M.S., Climent A.M., Chorro F.J., Trapero I., Pelechano F., Such-Miquel L., Millet J. Arterial Blood Flow Sensor...... 1158 D. Zikichand D. Zikic In-vivo measurements of heart ischemia using transoesophageal electrical impedance ...... 1163 Javier Rosell-Ferrer, Giuseppe Giovinazzo, Carol Galvez, Juan Ramos, Silvia Raga, Manel Sabate, Joan Cinca Photoplethysmographic Augmentation Index as a Non Invasive Indicator for Vascular Assessments...... 1167 R. Gonzalez, A. Manzo, J. Delgado, J.M. Padilla, B. Trenor, J.M. Ferrero (Jr), J. Saiz Thermoelectrical Stimulator for Patients´Quantitative Sensory Testing ...... 1171 J. Hozman, J. Hykel, J. Charfreitag and R. Cerny XXVIII Content

Transoesophageal Electronic Bioimpedance device for the study of post-transplant heart rejection ...... 1176 G. Giovinazzo, J. Ramos, J. Rosell Bio-compatible Insulated Substrate Impedance Transducers...... 1180 R.S. Pampin, L. Moreno-Hagelsieb, D. Flandre

Electrophysiological Systems

Macroconduction and microconduction during rapid pacing measured with cardiac near field technique...... 1184 E. Hofer, T. Wiener, R. Arnold, F. Campos, A.J. Prassl, D. Sanchez-Quintana, V. Climent and G. Plank An Efficient Piecewise Modeling of ECG Signals Based on Critical Samples Using Hermitian Basis Functions...... 1188 M. Abdoli, A. Ahmadian, S. Karimifard, H. Sadoughi and F. Yousefi Rizi Can orthogonal leads be derived from the standard electrocardiogram during atrial fibrillation?...... 1192 M.S. Guillem, A.M. Climent, A. Bollmann, D. Husser, J. Millet, F. Castells Abdominal Signal Processing: fetal ECG extraction by combining ESC and ICA methods...... 1196 D. arlung, W. Wolf, R. Strungaru and M. Ungureanu Use of Activation Time Based Kalman Filtering in Inverse Problem of Electrocardiography...... 1200 Umit Aydin, Yesim Serinagaoglu Comparison of Different Structures of Silver Yarn Electrodes for Mobile Monitoring ...... 1204 Alper Cömert, Markku Honkala, Baran Aydogan, Antti Vehkaoja, Jarmo Verho, Jari Hyttinen FPGA based two-channel ECG sensor node for wearable applications ...... 1208 J. Mihel, R. Magjarevic Emission Modelling for Supervised ECG Segmentation using Finite Differences...... 1212 B. Frénay, G. de Lannoy and M. Verleysen Towards a capacitively coupled electrocardiography system for car seat integration...... 1217 B.K. Chamadiya, S. Heuer, U.G. Hofmannand M. Wagner A mobile ECG monitoring system with context collection...... 1222 Li. J.P., Berry D. and Hayes R. Identification of Signal Components in Multi-Channel EEG Signals via Closed-Form PARAFAC Analysis and Appropriate Preprocessing...... 1226 Dunja Jannek, Florian Roemer, Martin Weis, Martin Haardt, and Peter Husar Analysis of Epileptic EEG Signals by Means of Empirical Mode Decomposition and Time-Varying Two-Sided Autoregressive modelling ...... 1231 A. Kacha, G. Hocepied and F. Grenez Neuroscience125 and Nonlinear Dynamics ...... 1236 W. Klonowski On Modelling User’s EEG Response During a Human-Computer Interaction: A Mirror Neuron System-Based Approach ...... 1241 P.C. Petrantonakis and L.J. Hadjileontiadis Microneedle array electrode for human EEG recording ...... 1246 R. Luttge, S.N. Bystrova and M.J.A.M. van Putten Generating Brain-maps with ICA Source Estimates from Hybrid Optimizer Using Spectral Screened EEG Data ...... 1250 S. Thomas George, S. Easter Selvan and Manoj Kumar Das Content XXIX

An Approximated Solution to the Inverse Problem of EEG...... 1255 X. Ibáñez-Català and M.I. Troparevsky The Removal Of Ocular Artifacts From EEG Signals: A Comparison of Performances For Different Methods..... 1259 M.A.Klados, C. Papadelis, C.D. Lithari and P.D. Bamidis Characteristic features of the EEG patterns during anaesthesia evoked by fluorinated inhalation anaesthetics ..... 1264 E. Olejarczyk, A. Sobieszek, R. Rudner, R. Marciniak, M. Wartak, M. Stasiowski, P. Jalowiecki Effects of propofol anesthesia on nonlinear properties of EEG: Time-lag and embedding dimension ...... 1268 J. Roca-González, M. Vallverdú-Ferrer, P. Caminal-Magrans, F. Martínez-González, J. Roca-Dorda and J.A. Álvarez-Gómez Effects of propofol anesthesia on nonlinear properties of EEG: Lyapunov exponents and short–term predictability...... 1272 J. Roca-González, M. Vallverdú-Ferrer, P. Caminal-Magrans, F. Martínez-González, J. Roca-Dorda and J.A. Álvarez-Gómez Imaging Magnetoencephalographic Independent Component Scalp Distributions using a Subspace Correlation Approach ...... 1276 C.W. Hesse Performance of ICA for MEG data generated from subspaces with dependent sources...... 1281 F. Kohl, G. Wübbeler, D. Kolossa, R. Orglmeister, C. Elster, M. Bär A robust independent component analysis algorithm for removing ballistocardiogram artifacts from EEG and fMRI recordings ...... 1286 T. Franchin, A.M. Bianchi, V. Cannatà, E. Genovese, F. Nocchi, S. Cerutti Monitoring of Musical ‘Motion’ in EEG Using Bispectral Analysis: A Mirror Neurons-based Approach ...... 1290 S.K. Hadjidimitriou, A.I. Zacharakis, P.C. Doulgeris, K.J. Panoulas, L.J. Hadjileontiadis, and S.M. Panas The somatosensory evoked response detection using coherence and different stimulation frequencies...... 1294 D.B. Melges, A.F.C. Infantosi and A.M.F.L. Miranda de Sá Reduction of alpha distortion in event related potentials ...... 1298 K. Vanderperren, B. Hunyadi, M. De Vos, M. Mennes, H. Wouters, B. Vanrumste, P. Stiers, L. Lagae and S. Van Huffel Measurement of high frequency EEG signals with very low noise amplifiers: Brain oscillations above 600 Hz measured non-invasively...... 1302 H.J. Scheer, G. Curio and M. Burghoff Comparison of spontaneous and event related measures in the electroencephalogram...... 1305 M.A. Schier Detection of Evoked Responses in EEG using Computational Intelligence Tools ...... 1309 A.P. Souza, A.M.F.L. Miranda de Sá, E.M.A.M. Mendes and L.B. Felix Influence of Branching and Tapering on Intracoronary Pressure and Flow Velocity: Comparison of Axial Measurement Location ...... 1313 F. Nolte, M. Remmelink, J.P. van den Wijngaard, S.J. Zweers, J. Baan, J.J. Piek, M. Siebes An active intravascular MR-probe using a miniature optical modulator ...... 1317 S. Fandrey, S. Weiss and J. Müller Circle Maps Analysis implemented on an intelligent, miniaturized and wireless communicating sensor enabling online cardiac arrhythmia classification ...... 1321 M. Schiek, M. Schlösser, A. Schnitzer, H. Ying An m-health system for continuous monitoring of children with suspected cardiac arrhythmias...... 1325 E. Kyriacou, C. Pattichis, M. Pattichis, A. Jossif, D. Vogiatzis, L. Paraskeva, A. Konstantinides, A. Kounoudes IR-thermal monitoring of cardiosurgery interventions ...... 1329 A. Nowakowski, M. Kaczmarek, W. Stojek, S. Beta, B. Trzeciak, J. Topolewicz, J. Rogowski, J. Siebert XXX Content

Monitoring Fluid Shifts During Haemodialysis Using Local Tissue Bioimpedance Measurement...... 1334 Omar.I. Al-Surkhi, P.J. Riu, F. Vazquez, J. Ibeas. MD Effect of a Sauna Bath and Smoking on a BCG, Carotid and Ankle Pulse Signal in Sitting Position ...... 1339 J. Alametsä, J. Viik, A. Palomäki Identifying Patients Suffering From Atrial Fibrillation During Atrial Fibrillation and Non-Atrial Fibrillation Episodes...... 1349 N. Kikillus, M. Schweikert and A. Bolz The Fetal Heart Rate Variability due to vibro-acustic stimulation: a complexity analysis...... 1353 M. Ferrario, M.G. Signorini and G. Magenes Normalization of the standard deviation and spectral indices of RR time series for comparison among situations with different mean heart rate...... 1357 M.A. García-González, M. Fernández-Chimeno, L. Capdevila, M. Ocaña, G. Rodas and J. Ramos-Castro Is the Ventricular Response during Atrial Fibrillation Certainly Random? ...... 1362 A.M. Climent, M.S. Guillem, D. Husser, F. Castells, J. Millet and A. Bollmann Influence of Mental Stress on Heart Rate and Heart Rate Variability...... 1366 J. Taelman, S. Vandeput, A. Spaepen and S. Van Huffel Anaesthesia with Propofol Reduces Ventricular Rhythm Variability during Atrial Fibrillation ...... 1370 R. Cervigón, F. Castells, C. Sánchez, A. Climent and J. Millet An algorithm for FHR extraction from FHS signals...... 1374 M. Cesarelli, M. Ruffo, M. Romano, P. Bifulco, F. Kovacs, S. Iaccarino Fetal ECG Extraction Using Multi-Layer Perceptron Neural Networks with Bayesian Approach ...... 1378 S. Mojtaba Golzan, Farzaneh Hakimpour, Mohammad Mikaili and Alireza Toolou Analysis of fetal movement based on magnetocardiographically determined fetal actograms and fetal heart rate accelerations ...... 1386 P. Van Leeuwen, D. Geue, S. Lange and D. Groenemeyer Identification of fetal auditory evoked cortical responses using a denoising method based on periodic component analysis...... 1390 L. Moraru, R. Sameni, U. Schneider, C. Jutten, J. Haueisen, D. Hoyer Development of neckband mounted active bio-electrodes for non-restraint lead method of ECG R wave...... 1394 A. Mizuno, H. Okumura and M. Matsumura Simultaneous registration of uterine contractions and fetal heart rate using magnetomyography and magnetocardiography ...... 1398 P. Van Leeuwen, W. Hatzmann, S. Schiermeier and D. Groenemeyer Comparison of reference subtraction methods for DC-MEG applications ...... 1402 W. Müller, T.H. Sander and M. Burghoff Reproducibility of Evaluation on Cardiac Autonomic Nervous System Activity through Tone-Entropy Analysis in Young Subjects ...... 1406 H. Nakamura and M. Yoshida On-line optimization of drug delivery: An adaptive extremum seeking approach...... 1410 D. Dochain, N. Hudon, M. Guay, M. Perrier Multi-level Mathematical Model of Rheological Study of Pathogenic Microorganisms Suspended in Water...... 1414 E.Yu. Taran and V.A. Gryaznova Numerical simulation of radial oscillations of individual and multiple microbubbles with elastic layers...... 1418 H.M. Overhoff, A. Poelstra, S. Euting, T. Gehrke Content XXXI

Monitoring of Insonicated Microbubble Behavior and their Effect on Sonoporation Supported Chemotherapy of Fibrosarcoma Cells ...... 1422 K. Hensel, M. Siepmann, K. Haendschke, S. Emmelmann, A. Daigeler, J. Hauser, G. Schmitz Efficient Transmembrane Segment Prediction in Transmembrane Proteins Using Wavelet-Based Energy Criteria...... 1426 I.K. Kitsas, L.J. Hadjileontiadis and S.M. Panas Towards User-friendly Interfacing of Biomedical Applications with the Grid: A Paradigm with SVM Optimization for Gene Prediction...... 1430 K.I. Vegoudakis, V. Koutkias, A. Malousi, I. Chouvarda and N. Maglaveras Pico-Injector for the Discrete Chemical Stimulation of Individual Cells with a High Temporal and Spatial Resolution...... 1434 J. Steigert, N. Wangler, O. Brett, M. Straßer, M. Laufer, M. Daub, and R. Zengerle A Novel Approach in Melanoma Identification ...... 1438 A.E. Oprea, R. Strungaru, A.M. Forsea and G.M. Ungureanu 3D cephalometry: a new approach for landmark identification and image orientation ...... 1442 S. Van Cauter, W. Okkerse, G. Brijs, M. De Beule, M. Braem and B. Verhegghe Methods for determining the blood flow velocity in cerebral vessels using intraoperative Indocyanine Green fluorescence video angiography...... 1446 P. Cimalla, D. Graf, P. Duscha, T. Meyer, J. Kuß, R. Steinmeier, E. Koch and U. Morgenstern Detection of Epileptic Seizures Through Audio Classification...... 1450 G.R. de Bruijne, P.C.W. Sommen and R.M. Aarts Automated Diagnosis of Early Alzheimer’s disease using Fuzzy Neural Network...... 1455 S. Mahesh Anand, M. Mukunda Rao, N. Shyam Prabhu, Samraj D. Simeon, D. Karthikeyan, and Snigdha Rashmi Dual camera based eye gaze tracking system...... 1459 T. Kocejko, A. Bujnowski and J. Wtorek Modeling of tooth’s structure based on CT and μCT data – comparative study...... 1463 S. Piszczatowski, J. Baginska, W. Swieszkowski Measurement of the short-term viscoelastic properties of the periodontal ligament using stress relaxation...... 1467 R. Tohill, M. Hien, N. McGuinness, L. Chung and R.L. Reuben Study of Electromyographic Signals During Chewing Process In Patients with Fixed Partial Denture ...... 1471 S. Kara, M. Tokmakç, Y. iman, E.T. Erta, E. mal, M.A. Özçoban Variation of Power Spectral Density and Energy in Electromyogram of Jaw-Closing Muscles in Children with Class II Malocclusion...... 1475 S. Kara, . Okkesim, F. Latifolu, T. Uysal, A. Baysal A high-resolution Schottky CdTe detector based spectrometric determination method of the kilovoltage applied to dental X-ray tubes...... 1479 B. Spyropoulos, G. Manousaridis, A. Papathymiou Analytical approach to determine the rotational freedom of dental implant-abutment connections ...... 1484 S. Kraft, W. Semper, K. Nelson and T. Krüger Physiologically inspired coding strategies for cochlear implants ...... 1488 A. Bahmer, G. Langner and U. Baumann Application of Otoplastics to Increase the Reproducibility of OAE-analyses...... 1492 T. Schmidt, A. Müller, Ch. Thron and H. Witte XXXII Content

Applicability of function-based analysis in retrospective data analysis of noise-induced hearing loss in the Finnish Defence Forces...... 1496 M. Hannula, T. Holma, H. Kiukaanniemi, P. Kuronen and M. Sorri 3D Tele-Medical Speech Therapy using Time-of-Flight Technology...... 1500 M. Stürmer, A. Maier, J. Penne, S. Soutschek, C. Schaller, R. Handschu, M. Scibor, E. Nöth Augmented control of hands free voice prostheses...... 1504 Brian Madden, James Condron, Ted Burke, Eugene Coyle EMD-KURTOSIS: A New Classification Domain for Automated Greek Sign Language Gesture Recognition ...... 1508 V.E. Kosmidou and L.J. Hadjileontiadis

Clinical Engineering

Differentiation between Brain Metastasis and Glioblastoma using MRI and two-dimensional Turbo Spectroscopic Imaging data...... 1513 T. Laudadio, J. Luts, M. Carmen Martínez-Bisbal, Bernardo Celda and Sabine Van Huffel A high performance bidirectional micropump utilizing advanced low voltage piezo multilayer actuator technology for a novel artificial sphincter system...... 1517 T. Lemke, G. Biancuzzi, C. Farhat, B. Vodermayer, O. Ruthmann, T. Schmid, H.-J. Schrag, P. Woias and F. Goldschmidtboeing The method of assessment of chosen hemodynamic and electrophysiologic parameters in the healthy human subject circulation...... 1521 K. Peczalski, D. Wojciechowski, P. Sionek, Z. Dunajski, T. Palko Tissue Recognition for Pressure Ulcer Evaluation ...... 1524 H. Mesa, L. Morente and F. Veredas A System Ergonomic Analysis Approach for Potential Critical Incidents in Medical Treatment Processes...... 1528 Daniela Fuchs, Beate Eilermann, Ingo Marsolek, Wolfgang Friesdorf, Dirk Pappert Determination of the Mechanical Leg Axis Using a Force-Torque Sensor ...... 1532 R. Elfring, F. Schmidt, M. de la Fuente, W. Teske and K. Radermacher Automatic Discrimination of Duodenum inWireless Capsule Video Endoscopy...... 1536 L. Igual, J. Vitrià, F. Vilariño, S. Seguí, C. Malagelada, F. Azpiroz and P. Radeva Ontology-based Computer-Aided Decision System: a new architecture and application concerning the musculoskeletal system of the lower limbs...... 1540 T.T. Dao, F. Marinand M.C. Ho Ba Tho Multi- tactile sensor concept for the autonomous navigation in human blood vessels ...... 1544 A. Keißner, C. Brücker, P. Jacobs, A. Kashefi Studies on Viscosity, pH and Temperature of High Concentration Barium Sulfate in Mass Screening for Gastric Cancer – Particle size distribution –...... 1548 K. Yamamoto, Y. Takeda C. Kuroda, T. Kubo, T. Gotanda, A. Tabuchi, H. Yatake, T. Kuwano, T. Katsuda, H. Yamazaki and M. Azuma Blood pressure response to LBNP load in various types of examinations ...... 1552 J. Hanousek, P. Dosel, J. Petricek and L. Cettl Study on the measurement of ejection fraction (EF) using left ventriculogram ...... 1556 Tadao Kuwano, Toshizo Katsuda, Kenyu Yamamoto, Tatsuhiro Gotanda, Takashi Horinouchi, Shodayu Takashima, Masami Azuma and Yoshihiro Takeda Content XXXIII

Exposure Dose in Gastric Cancer Mass Screening using High Concentration Barium Sulfate – Comparison with Moderate Concentration Barium Sulfate –...... 1561 K. Yamamoto, M. Azuma, T. Katsuda, T. Kubo, M. Takeshita, K. Yabunaka, R. Gotanda, K. Hayashida, C. Kuroda and Y. Takeda Simulation and Experimental Study of an Ellipsoidal Cavity Reflector as part of a Focused Passive Brain Imaging System...... 1565 K.T. Karathanasis, I.A. Gouzouasis, I.S. Karanasiou and N.K. Uzunoglu The Impact of Model-based Therapeutics on Glucose Control in an Intensive Care Unit ...... 1570 Christopher E. Hann, J. Geoffrey Chase, Thomas Desaive, Michael F. Ypma, Jos Elfring and Geoffrey M. Shaw A comparison of gesture and speech control in intraoperative-near environment...... 1574 A. Rose, D. Eichel and T. Krueger Incident Investigation in the Healthcare System: a Comparative Analysis Derived from the Chemical Industries...... 1577 P.P. Morita, S.J. Calil Health Technology Management: Medical Equipment Classification...... 1581 N.F. Oshiyama, A.C. Silveira and J.W.M. Bassani Quality Assurance and Control of Clinical Engineering Activities...... 1585 W.S. Trarawneh, A. Ghawanmeh, I. Malkawiand M. Ghannam Active path selection of fluid microcapsules by acoustic radiation force in the artificial blood vessel ...... 1589 Y. Muramatsu, S. Ueda, R. Nakamoto, Y. Nakayashiki, K. Masuda, K. Ishihara Fatigue Testing of Polyimide-Based Micro Implants ...... 1594 S. Kisban, D. Moser, B. Rubehn, T. Stieglitz, O. Paul and P. Ruther T2 weighted liver Magnetic Resonance imaging using functional residual capacity breath-hold with multi breath-hold ...... 1598 A. Tabuchi, T. Katsuda, R. Gotanda, T. Gotanda, K. Yamamoto, M. Mitani, Y. Takeda The usefulness of film reading to detect cancer by untrained radiographer in X-ray examination of the stomach ...... 1603 H. Yatake, T. Katsuda, C. Kuroda, H. Yamazaki, T. Kubo, R. Gotanda, K. Yabunaka, K. Yamamoto, Y. Sawai and Y. Takeda A novel method for automatic evaluation of the effective dynamic range of medical ultrasound scanners...... 1607 A. Scorza On the development of a powered prosthesis for transtibial amputees ...... 1612 R. Versluys, A. Desomer, G. Lenaerts, R. Van Ham, I. Vanderniepen, L. Peeraer, and D. Lefeber Patient-Driven Cooperative Gait Training with the Rehabilitation Robot Lokomat...... 1616 A. Duschau-Wicke, J. v. Zitzewitz, L. Lünenburger and R. Riener Improving Speech Understanding in Noise for Users of Bone Anchored Hearing Aids (BAHA) ...... 1620 F. Pfiffner, C. Stieger and M. Kompis AERBUS: Enhanced perception of the environment for visually impaired people...... 1624 K. Möller, V. Balazs, F. Toth, S. Schumann, K.O. Arras, M. Bach, J. Guttmann Selective stimulation of the vagus nerve in a man...... 1628 P. Pelin, I. Kneževi, T. Mirkovi, B. Geršak, I. Radan, M. Podbregar and J. Rozman Improved Wearable Monitoring System for Posture Changes and Walking Speed and its Application to Supporting Physical Therapist in Rehabilitation ...... 1632 K. Motoi, Y. Kuwae, M. Wakugawa, Y. Toyonaga, T. Yuji, Y. Higashi, T. Fujimoto, S. Tanaka and K. Yamakoshi Arterial Elasticity Measurements with Ankle Pulse Width Velocity and Ballistocardiography ...... 1636 J. Alametsä, J. Viik, A. Palomäki XXXIV Content

A bioimpedance measurement device for sensing force and position in neuroprosthetic systems...... 1642 H. Nahrstaedt and T. Schauer Unraveling of an original mechanism of hypometria in human using a new myohaptic device – The Wristalyzer ...... 1646 M. Manto, G. Grimaldi, P. Jissendi, N. Van Den Braber, J. Meulemanand P. Lammertse The “Highly Versatile Single Port System” for laparoscopic surgery: Introduction and first clinical application...... 1650 S. Can, H. Mayer, A. Fiolka, A. Schneider, D. Wilhelm, H. Feussner, A. Knoll A Locomotive System Mimicking Pedal Locomotion of Snails for the Capsule Endoscope ...... 1655 Daisuke Hosokawa, Takuji Ishikawa, Hirohisa Morikawa, Yohsuke Imai and Takami Yamaguchi A Novel Laparoscopic Instrument with Multiple Degrees of Freedom and Intuitive Control ...... 1660 H.F. Schlaak, A. Röse, C. Wohlleber, S. Kassner, R. Werthschützky A Modified Zwicky's Morphological Analysis: Application to the design of a robotic laparoscope...... 1664 G.Villegas Medina, M.T. Phamand W. Marquis-Favre Position Control of Piezoelectric Motors for a Dexterous Laparoscopic Instrument...... 1668 C. Wohlleber, H.F. Schlaak A system to provide different view fields to both eyes of human respectively...... 1672 F. Mizuno, K. Sawaguchi, T. Haga, T. Hayasaka and T. Yamaguchi Knowledge-based OR table positioning assistant for orthopedic surgery...... 1676 W. Lauer, B. Ibach and K. Radermacher Bone mounted hexapod robot for outpatient distraction osteogenesis...... 1679 R. Wendlandt, F. Wackenhut, K. Seide and J. Müller Synergistic CT based tele-manipulator for needle placement in spine procedures ...... 1683 V.C.V.S. Cunha-Cruz, S. Serefoglou, P. Bruners, A.H. Mahnken and K. Radermacher Design Results of an Upper Extremity Exoskeleton ...... 1687 S. Moubarak, M.T. Pham, T. Pajdla and T. Redarce The development of endoscopic surgery for a training simulator...... 1691 S. Yoneyama, H. Koyama, T. Komeda and S. Yamamoto Haptic Aided Roboting for Heart Surgeons ...... 1695 E.U. Braun, C. Gaertner, H. Mayer, A. Knoll, R. Lange, R. Bauernschmitt Laparoscope Sizing Approach Based on the Virtual Exploration of the liver's Surface...... 1697 G. Villegas Medina, M.T. Pham and W. Marquis-Favre Probabilistic Forecasts of Epileptic Seizures and Evaluation by the Brier Score...... 1701 M. Jachan, H. Feldwisch genannt Drentrup, F. Posdziech, A. Brandt, D.-M. Altenmüller, A. Schulze-Bonhage, J. Timmer, B. Schelter A Long-Term Monitor Including Activity Classification for Motor Assessment in Parkinson’s Disease Patients.... 1706 D.G.M. de Klerk, J.P.P. van Vugt, J.A.G. Geelen and T. Heida iNODE: intelligent Network Operating Device for Neurological and Neurophysiological Research ...... 1710 Mario Schlösser, Andreas Schnitzer, Hong Ying, Carmen Silex, Michael Schiek Distributed Intelligent Sensor Network for Neurological Rehabilitation Research ...... 1714 H. Ying, M. Schlösser, A. Schnitzer, S. Leonhardt and M. Schiek Online Laser Doppler Measurements of Myocardial Perfusion...... 1718 C. Fors, H. Ahn and K. Wårdell Content XXXV

A Clinically Validated Patient Monitoring System...... 1722 A. Ridolfi, O. Chetelat, J. Krauss, J. Sola, O. Grossenbacher and S.M. Jakob Process Mapping, a key milestone in Engineering for Health ...... 1726 Eng. Francesco Amorosi, Ph.D. Allocation of Medical Equipment Costs to Medical Procedures ...... 1730 L.N. Nascimento, S.J. Calil Supporting Clinical Information Management by NFC Technology...... 1734 J. Bravo, G. Casero, M. Vergara, C. Fuentes, R. Peña, R. Hervás & V. Villarreal Towards Noninvasive Monitoring of Total Hemoglobin Concentration and Fractional Oxygen Saturation Based on Earlobe Pulse Oximetry...... 1738 O. Abdallah, K. Abo Alam, A. Bolz Visual Transformation of the EEG in the Intensive Care...... 1743 Michel J.A.M. van Putten Development of a mobile toilet system servicing elderly on call...... 1747 Ueno S., Imai Y., Hayasaka T., Okubo M., Ishikawa T. and Yamaguchi T. Optimal Electrode Configurations for Impedance Pneumography during Sports Activities...... 1750 O. Lahtinen, V.-P. Seppä, J. Väisänen and J. Hyttinen Improving model-based cardiac diagnosis with an ECG...... 1754 C.E. Hann, J.G. Chase, C.F. Froissart, C. Starfinger, T. Desaive, K. Kok, J. Revie, A. Ghuysen, B. Lambermont, P. Kolh and G.M. Shaw Electronic Monitoring of Head Position after Vitrectomy...... 1758 M. Cizek, J. Dlouhy, I. Vicha and J. Rozman Investigation of Heart Rate Variability after Cardiopulmonary Resuscitation and Subsequent Hypothermia ...... 1762 J. Hopfe, R. Pfeifer, C. Ehrhardt, M. Goernig, H.R. Figulla, A. Voss Development of Non-restrained Sleep-Monitoring Method by Using Difference Image Processing ...... 1765 Okada S., Ohno Y., Kenmizaki K., Tsutsui A. and Wang Y. Hard- and software-configurable system for preoperative planning and intraoperative navigation of minimally invasive interventions...... 1769 U. von Jan, D. Sandkühler, S. Maas and H.M. Overhoff Laser Treatment of Radiation Injuries of Skin and Underskin Tissues ...... 1773 V. Ovsyannikov, G. Zharinov, S. Gosteva, G. Zaikin, A. Bushmanov, N. Nadyozhina

Musculo-skeletal, Joint & Bone Biomechanics

A Validated Skeleton-based Finite Element Mesh for Parametric Analysis of Trabecular Bone Competence ...... 1777 J. Vanderoost, S.V.N. Jaecques, G. Van der Perre, S. Boonen, J. D’hooge, W. Lauriks and G.H. van Lenthe A Mechanical Instrument to Evaluate Posture of the Spinal Column in Pregnant Women...... 1781 Mario Forjaz Secca, Cláudia Quaresma, Filipe Santos Hardware-in-the-Loop-Simulator for Testing of Total Hip Endoprostheses...... 1785 M. Kähler, R. Souffrant, S. Dryba, D. Kluess, R. Bader and C. Woernle Experimental and numerical analysis of patello-femoral contact mechanics in TKA...... 1789 B. Innocenti, M. Follador, M. Salerno, C. Bignardi, P. Wong and L. Labey Microstructural quality of vertebral trabecular bone can be assessed from ultrasonic wave propagation ...... 1794 L. Goosssens, J. Vanderoost, S.V.N. Jaecques, S. Boonen, J. D’hooge, G.H. Van Lenthe, W. Lauriks and G. Van der Perre XXXVI Content

Contact pressure distribution in postmortem human knee during dynamic flexion-extension movement...... 1798 J. Quintelier, P. De Baets and F. Almqvist Predictive Mathematical Models based on Data Mining Methods of the Pathologies of the Lower Limbs ...... 1803 T.T. Dao, F. Marin and M.C. Ho Ba Tho Periprosthetic Fields and Currents of an Electrostimulative Acetabular Revision System...... 1808 C. Potratz, H.-W. Glock, R. Souffrant, R. Bader, H. Ewald, U. van Rienen Modeling of the children’s hip joint in diagnostics of bone deformation in cerebral palsy ...... 1812 S. Piszczatowski, M. Okonski Signal processing concepts for optimal myoelectric sensor placement in a modular hybrid FES orthosis ...... 1816 O. Schill, R. Rupp and M. Reischl Invention of slight lower limbs’ stretching and walking orthosis...... 1820 K.L. Yamamoto, T. Matsuda, E. Genda, Y. Suzuki, K. Kinoshita, Y. Iwamura, M. Izumino A proof-of-concept exoskeleton for robot-assisted rehabilitation of gait...... 1825 P. Beyl, P. Cherelle, K. Knaepen and D. Lefeber Physiologic Approach for Control of Hand Prostheses...... 1830 K.H. Somerlik, T.B. Krueger, J. Carpaneto, T. Stieglitz and S. Micera Accelerometer based measurement of body movement for communication, play, and creative expression ...... 1835 M. Nolan, E. Burke and F. Duignan Wheelchair Direction Control by Acquiring Vocal Cords Vibration with Multivariate Analysis ...... 1839 Chia-Hua Hsu, Huai-Yuan Hsu Hsin-Yi Wang Tzu-Chien Hsiao Evaluation of Trajectory Applied to Collaborative Rehabilitation For a Wheelchair Driving Simulator...... 1843 I. Randria, A. Abellard, M. Ben Khelifa, P. Abellard, P. Ramanantsizehena A New Concept of an Electrostimulative Acetabular Revision System with Patient Individual Additional Fixation...... 1847 D. Kluess, R. Souffrant, R. Bader, U. van Rienen, H. Ewald, W. Mittelmeier Effect of splinting in a fixed partial denture on bone remodeling using FEM ...... 1851 M.T. El-Wakad Finite element study of load transfer in a splinted fixed partial denture...... 1856 M.Z. Bendjaballah Electric Stimulation and Pudendal Evoked Potential Recordings for Management of Stress Incontinence in Women ...... 1862 C. Koutsojannis An in-vitro study of human knee kinematics: natural vs. replaced joint...... 1867 B. Innocenti, L. Labey, J. Victor, P. Wong and J. Bellemans An EMG control system of ultrasonic motors using PSoC microcomputer...... 1871 Yorihiko Yano and Kenta Mukai

Cardiac Mechanics

Visualization and modeling of flow in the embryonic heart ...... 1875 F. Maes, B. Chaudhry, P. Segers, P. Van Ransbeeck, P. Verdonck An Innovative Design of a Blood Pump Actuator Device using an Artificial Left Ventricular Muscle...... 1879 B. Van Der Smissen Benjamin, T. Claessens, P. Verdonck, P. Van Ransbeeck, P. Segers Content XXXVII

Artificial heart constructed as a kinetic calotte-pendulum-transmission ...... 1883 H.A. Vielberg M. D. Estimation of cardiac contractility during rotary blood pump support using an index derived from left ventricular pressure...... 1885 P. Naiyanetr, F. Moscato, M. Vollkron, D. Zimpfer, S. Sandner, G. Wieselthaler, H. Schima

Vascular and Biofluid Mechanics

Impact of imaging modality for analysis of a cerebral aneurysm: comparison between CT, MRI and 3DRA...... 1889 J. Poethke, L. Goubergrits, U. Kertzscher, A. Spuler, Ch. Petz and H.-Ch. Hege Computational modeling of cerebral aneurysm formation - framework for modeling the interaction between fluid dynamics, signal transduction pathways and arterial wall mechanics...... 1894 H. Schmid, P. Watton, M. McCormick, Y. Lanir, H. Ho, C. Lloyd, P. Hunter, A. Ehret and M. Itskov Circumferential variations in passive and active mechanical properties of healthy and aneurysmal ascending aorta...... 1899 D. Tremblay, R. Cartier, L. Leduc, J. Butany, R. Mongrain, R.L. Leask Arterial Remodeling in Response to Increased Blood Flow Using a Constituent-Based Model...... 1903 A. Tsamis and N. Stergiopulos Research of Ride Comfort for Tilting Train Simulator Using ECG ...... 1906 Youngbum Lee, Kwangsoo Shin, Yongsoo Song, Sungho Han and Myoungho Lee Strain energy function for arterial walls based on limiting fiber extensibility...... 1910 L. Horny, R. Zitny and H. Chlup Carotid plaque and its effect on ultrasound carotid distension measurements ...... 1914 T. De Schryver, J. Kips, A. Swillens and P. Segers Relation Between Left Ventricular Relaxation Rate and Arterial Loading ...... 1918 T.E. Claessens, E.R. Rietzschel, M.L. De Buyzere, D. De Bacquer, G. De Backer, T.C. Gillebert, P.R. Verdonck and P. Segers Impact of aortic valve stenosis on left coronary artery flow: An in vitro study...... 1922 E. Gaillard, D. Garcia, L. Kadem, P. Pibarot and L.-G. Durand Pulsatile Blood Flow Simulations in Aortic Arch: Effects of Blood Pressure and the Geometry of Arch on Wall Shear Stress...... 1926 P. Vasava, P. Jalali and M. Dabagh Linking an Artery to the Circulation: Introducing a Quasi-Simultaneous Coupling Approach for Partitioned Systems in Hemodynamics...... 1930 G. Rozema, N.M. Maurits and A.E.P. Veldman Mechanical Properties of Arteries with Aging and its Noninvasive Estimation Method ...... 1935 F. Nogata, Y. Yokota, Y. Kawamura, W.R. Walsh, H. Morita and Y. Uno Accuracy Close to the Wall of Immersed Boundary Methods...... 1939 M. Pourquie A modified Mass-Spring system for myocardial mechanics modeling...... 1943 O. Jarrousse, T. Fritz and O. Dössel The Significance of Flow Unsteadiness on the Near-Wall Flow of a Stented Artery...... 1947 Juan Mejia, Rosaire Mongrain, Richard Leask, Josep Cabau-Rodes and Olivier F. Bertrand A mechanical study of patient-specific cerebral aneurysm models: a correlation between stress and geometrical index ...... 1951 A. Valencia, P. Torrens, R. Rivera, M. Galvez and Eduardo Bravo XXXVIII Content

Simulation of wall shear stress-driven in-stent restenosis...... 1955 G. De Santis, P. Mortier, M. De Beule, P. Segers, P. Verdonck, B. Verhegghe Microfluidic Modeling of Circulating Leukocyte Deformation...... 1959 S. Gabriele, A.-M. Benoliel, P. Bongrand and O. Theodoly Image-based Blood Flow Simulation in the Retinal Circulation ...... 1963 D Liu, N.B. Wood, X.Y. Xu, N. Witt, A.D. Hughes, S.A. Thom Finite Element Modeling of LDL Transport in Carotid Artery Bifurcations ...... 1967 A.I. Sakellarios, D.I. Fotiadis and L.K. Michalis Micro-PIV as a research tool for in vivo studies of vascular remodeling ...... 1972 C. Poelma, B.P. Hierck and J. Westerweel Numerical simulation and Experimental Validation in an Exact Aortic Arch Aneurysm Model...... 1975 S. Seshadhri, G. Janiga, B. Preim, G. Rose, M. Skalej, D. Thévenin The 3D Flow Analysis in Ruptured Cerebral Aneurysm ...... 1980 M.L. Li, Y.C. Wang, H.D. Hsiao, L.C. Lee, K.C. Hung

Selected Topics in Biomechanics

Sensor placement with a telescoping compliant mechanism...... 1987 S. Griebel, L. Zentner, V. Böhm and J. Haueisen The Cement-Bone Interface: Is It Susceptible To Damage Adaptive Remodeling? ...... 1990 A.B. Lennon and P.J. Prendergast Wall shear stress in the mouse aortic arch : Does size matter?...... 1994 B. Trachet, A. Swillens, D. van Loo, C. Casteleyn, A. De Paepe, B. Loeys, P. Segers The Role of Arterial Wall Deformation on the Shear Stress over the Cardiovascular Smooth Muscle Cells: Computations in Two-Dimensional Geometry...... 1999 M. Dabagh, P. Jalali Adapting a Mass-Spring system to energy density function describing myocardial mechanics...... 2003 Thomas Fritz, Oussama Jarrousse and Olaf Dössel Fabrication of thin and flexible PDMS membranes for biomechanical test applications ...... 2007 C. Armbruster, M. Schneider, K. Gamerdinger, S. Schumann, M. Cuevas, E. Koch and J. Guttmann Dual-Camera Spherical Indentation System for Examining the Mechanical Characteristics of Hydrogels...... 2011 M. Ahearne, K.K. Liu and Y. Yang Morphological and Functional Flow-Induced Response of Endothelial Cells and Adhesive properties of Leukocytes in 3D Stenotic Models ...... 2015 L. Rouleau, M. Farcas, I. Copland, J.-C. Tardif, R. Mongrain and R.L. Leask Development of an experimental device for the application of static and dynamic tensile strain on cells...... 2019 S. Reimann, B. Rath-Deschner, J. Deschner, L. Keilig, A. Jäger and C. Bourauel Dynamic Videomicroscopy reveals correspondence between mechanical characteristics of lung tissue and local morphology on alveolar scale ...... 2023 S. Schumann, K. Gamerdinger, C. Dassow, C. Armbruster, M. Schneider, S. Uhlig, J. Guttmann Differences in form stability between human non-tumorous alveolar epithelial cells type 2 and alveolar carcinoma cells under biaxial stretching ...... 2027 S.J. Schließmann, K. Höhne, A. Charra, A. Kirschbaum, B. Cucuruz, S. Schumann, G. Zissel and J. Guttmann Content XXXIX

Simulation of tissue differentiation in a mechanically loaded bone regeneration chamber...... 2031 H. Khayyeri, S. Checa, M. Tagil and P.J. Prendergast Three-dimensional Imaging of subpleural Alveoli by Fourier Domain Optical Coherence Tomography ...... 2035 S. Meissner, L. Knels, M. Mertens, M. Wendel, A. Tabuchi, W.M. Kuebler, T. Koch, E. Koch The role of ventilation frequency in airway reopening ...... 2040 K. Bauer, Ch. Brücker, G. Simbruner and M. Rüdiger Cardiogenic oscillations reflect the compliance of the respiratory system ...... 2045 A. Wahl, L. Vimlati, K. Möller, S. Schumann, R. Kawati, J. Guttmann, M. Lichtwarck-Aschoff On the separate determination of lung mechanics in in- and expiration...... 2049 K. Möller, Z. Zhao, C. Stahl, S. Schumann, and J. Guttmann Novel artificial lung model for respiration measurement and demonstration ...... 2053 K. Stiglbrunner, M. Wurm, M. Weingant, J. Mader, A. Drauschke and P. Kroesl Measurement of tidal volumes in case of high frequency oscillation ventilation ...... 2057 M. Wurm, A. Drauschke, J. Mader, K. Stiglbrunner, M. Weingant, J. Bawitsch and P. Krösl

Gait and Motion Analysis

Effect of Viscoelastic Constraints to Kinematic Parameters during Human Gait...... 2061 T. Miyoshi, N. Sasagawa, S.-I. Yamamoto, T. Komeda and K. Nakazawa Muscle electrical activity during force modulation exercise...... 2065 M. Mischi and M. Cardinale Correspondence between Muscle Motion and EMG Activity during Whole Body Vibration...... 2069 Antonio Fratini, Paolo Bifulco, Mario Cesarelli, Giulio Pasquariello, Maria Romano, Antonio La Gatta Study and implementation of a wireless accelerometer network for gait analysis ...... 2073 J. Stamatakis, P. Gérard, P. Drochmans, T. Kezai, B. Caby, B. Macq and D. Flandre Sensitivity of posturography to elimination of visual feedback...... 2077 T. Schnupp, M. Holzbrecher-Morys, D. Mandic and M. Golz Impact analysis of shoes using the structural intensity technique...... 2081 F. Cui, H.P. Lee, X. Zeng Comparing the Biomechanics of Crouch Gait in Children with Cerebral Palsy to that of Age-Matched Controls and Young Healthy Adults...... 2085 Md.Z. Karim, R. Hainisch, A. Kranzl, M. Gfoehler and M.G. Pandy Power spectral distribution analysis for detection of freezing of gait in patients with Parkinson’s disease...... 2089 H. Zabaleta, T. Kellerand J.F. Martí Massó Predictive control continues after collision in self-induced impulsive loading: preliminary study...... 2093 Y. Bleyenheuft, P. Lefèvre, J.L. Thonnard Does slippage influence the EEG response to load force variations during object manipulation? ...... 2097 T. André, J. Delbeke, P. Lefèvre and J.-L. Thonnard Visuomotor velocity transformations for visually guided manual tracking...... 2101 G. Leclercq, G. Blohm and P. Lefèvre Towards a High Performance Expert System for Gait Analysis...... 2105 V. Medved, V. Ergovic and S. Tonkovic Feed forward compensation of hyper gravity in vertical pointing movements...... 2109 F. Crevecoeur, J.-L. Thonnard and P. Lefèvre XL Content

Changes of muscle fiber length in vivo during walking as revealed by ultrasound images ...... 2113 N. Sasagawa, T. Miyoshi, S.-I. Yamamoto Effect of the pull-down force magnitude on the external work during running in weightlessness on a treadmill..... 2116 T.P. Gosseye, N.C. Heglund and P.A. Willems Objective analysis of lower limb movements of infants for diagnostic purposes: calculation of the knee joint center ...... 2120 D. Karch, K. Kim, K. Wochner, H. Philippi, J. Pietz and H. Dickhaus Fall prevention by vibration stimuli to planta pedis...... 2124 M. Yoshida, D. Kan, M. Takeoka and S. Mouri Different Contraction Pattern of Lower Leg Muscle Fiber between Swaying and Tiptoe Standing in Human Upright Posture ...... 2128 S. Yamamoto, C. Shimizu, H. Yamamoto, N. Sasagawa, T. Miyoshi, H. Koyama, T. Komeda Influence of visual information on optimal obstacle crossing...... 2133 S.T. Rodrigues, A. Forner-Cordero, V.D. Garcia, P.F.P. Zagoand H. Ferasoli Significance of the body-weight’s ratio of caregiver and receiver in the training process of care-giving motion...... 2138 Y. Koshino, Y. Ohno Biological motion input to the oculomotor system...... 2142 Coppe S., Orban de Xivry J.J., Missal M., Lefevre P. Compensation for smooth eye and head movements by gaze saccades during head-unrestrained tracking...... 2146 P. Daye, G. Blohm and P. Lefèvre Diagnostics of Human Body Stem Motor Functions by Systematic Provocation Method ...... 2150 H. Witte, E. Andrada, T. Kikova, M. Heinze and C. Ament Cross education after power training ...... 2153 A. Mastalerz, G. Lutosawska and C. Urbanik Development of a Sit-to-Stand Assistance System ...... 2157 Kosuke Tomuro, Osamu Nitta, Yoshiyuki Takahashi, Takashi Komeda

Biomaterials, Tissue Engineering, Artificial Organs and Implants

Laser generated scaffolds for regeneration of the auditory nerve and facial nerve ...... 2161 G. Hohenhoff, J.K. Krauss, K. Schwabe, M. Nakamura, K. Haastert, and M. Hustedt Experimental setup for high mechanical strain induction to cell loaded metallic biomaterials ...... 2165 T. Habijan, T. Glogowski, S. Kühn, M. Pohl, G. Muhr and M. Köller Stent Design for Gastrointestinal Leakage...... 2169 R.A. Rothwell, G.A. Thomson, M.S. Pridham Textile blood vessels coated with DLC...... 2173 M. Jelinek, J. Podlaha, T. Kocourek, V. Žížková Finite-element-analysis and in vitro study of bioabsorbable polymer stent designs...... 2175 C. Schultze, N. Grabow, H. Martin and K.-P. Schmitz Influence of crystallinity on bio- physical properties of hydroxyapatite films...... 2179 M. Jelinek, T. Dostálová, T. Kocourek, V. Studnika, M. Seydlová, Z. Teuberová, P. Kíž, B. Dvoánková, K. Smetana Jr, J. Kadlec, M. Vrbová Novel, Biocompatible and Photo Crosslinkable Polymeric Networks based on Unsaturated Polyesters: Optimization of the Network Properties...... 2182 N.K. Mohtaram, M. Imani, Sh. Sharifi, H. Mobedi and M. Atai Content XLI

The Use of Fibrin as an Autologous Scaffold Material for Cardiovascular Tissue Engineering Applications: From In Vitro to In Vivo Evaluation ...... 2186 T.C. Flanagan, J. Frese, J.S. Sachweh, S. Diamantouros, S. Koch, T. Schmitz-Rode and S. Jockenhoevel Continuous oxygen consumption estimation method for animal cell bioreactors based on a low-cost control of the medium dissolved oxygen concentration...... 2190 A. Fontova, A. Soley, J. Gálvez, E. Sarró, M. Lecina, J. Rosell, P.J. Riu, J. Cairó, F. Gòdia and R. Bragos Capillary network formation during tissue differentiation. A mechano-biological model ...... 2195 S. Checa and P.J. Prendergast Formed 3D Bio-Scaffolds via Rapid Prototyping Technology...... 2200 P.S. Maher, R.P. Keatch, K. Donnelly and J.Z. Paxton Design and Construction of a System for the Application of Variable Pressure to Tissue Engineered Blood Vessels...... 2205 Stefanos E. Diamantouros, Thomas C. Flanagan, Thomas Finocchiaro, Thomas Schmitz-Rode, Stefan Jockenhoevel Remedi: A Research Consortium Applying Engineering Strategies to Establish Regenerative Medicine as a New Industry ...... 2209 M.L. Mather, J.A. Crowe, S.P. Morgan, L.J. White, K.M. Shakesheff, S.M. Howdle, R.J. Thomas, H.M. Byrne, S.L. Waters, D.J. Williams A Biodegradable Balloon-expandable Stent for Interventional Applications in the Peripheral Vasculature – In vitro Feasibility ...... 2213 N. Grabow, C.M. Bünger, C. Schultze, W. Schmidt, K. Sternberg, W. Schareck and K.-P. Schmitz A membrane-based voice-producing element for female laryngectomized patients...... 2216 J.W. Tack, H.A.M. Marres, C.A. Meeuwis, E.B. van der Houwen, G. Rakhorst, G.J. Verkerke Fully implantable alloplastic urinary bladder ...... 2220 M. Roth, H. Wassermann and D. Jocham Physical and dynamic models of the eye for tonometry applications...... 2223 M.R. Hien, R.L. Reuben, J. Hammer, R.W. Else, C. Muir Temperature dependence of water absorption for wavelengths at 1920 nm and 1940 nm...... 2228 Dirk Theisen-Kunde, Veit Danicke, Mario Wendt, Ralf Brinkmann Manufacturing of bone substitute implants using Selective Laser Melting...... 2230 S. Hoeges, M. Lindner, H. Fischer, W. Meiners and K. Wissenbach Development of Drug-Eluting Stents on the Basis of Genistein and Poly(L-lactide)...... 2235 Katrin Sternberg, Niels Grabow, Marian Löbler, Michael Petzsch, Janusz Lipiecki, Claus Harder, Christoph Nienaber, Klaus-Peter Schmitz Coating homogeneity in the manufacture of Drug-Eluting Stents ...... 2240 C. Gocke, N. Grabow, C. Schultze, K. Sternberg, W. Schmidt and K.-P. Schmitz Characterization of textile conductors for Bioimpedance Spectroscopy ...... 2244 Lisa Beckmann, Christian Neuhaus, Nadine Zimmermann, Harald Mai and Steffen Leonhardt Analysis of mechanical properties of liver tissue as a design criterion for the development of a haptic laparoscopic tool ...... 2248 S. Kassner, J. Rausch, A. Kohlstedt and R. Werthschützky Registered Microhardness of human teeth parts and dental filling composites...... 2252 L. Schmitt, C. Lurtz, D. Behrend and K.-P. Schmitz Quantitative High Speed Video Analysis of Biopolymer Encapsulated Cells while Capsule Formation...... 2255 I. Meiser, S.C. Müller,M.M. Gepp,H. Zimmermann, F. Ehrhart XLII Content

Chemical modification of polymeric implant surfaces for local drug delivery ...... 2259 M. Teske, H.W. Rohm, N. Grabow, K.-P. Schmitz and K. Sternberg Synthesis of Hydrolytically Stable Monomers for Dental Adhesives ...... 2263 N. Moszner, J. Angermann, F. Zeuner and U. Fischer Time and pH dependence of adsorption of chlorhexidine on anatase and rutile titanium dioxide ...... 2265 Yanqing Hu, Michele E. Barbour, Geoffrey C. Allen Local drug delivery from hydroxyapatite ceramic fibres ...... 2269 M. Ravelingien, N. Smets, S. Mullens, J. Luyten, C. Vervaet, J.P. Remon Considerations in the development of novel functional monomers for dental resin composites ...... 2273 T. Buruiana, V. Melinte, E.C. Buruiana, M. Moldovan, C. Prejmerean Development of a Production Process for Stem Cell Based Cell Therapeutic Implants Using Disposable Bioreactor Systems ...... 2277 C. Weber, S. Pohl, R. Poertner, C. Wallrapp, P. Geigle, and P. Czermak Using MEA system in verifying the functionality of retinal pigment epithelium cells differentiated from human embryonic stem cells ...... 2281 N. Nöjd, T. Ilmarinen, L. Lehtonen, H. Skottman, R. Suuronen and J. Hyttinen Tubular scaffold design of polylactide acid for nerve tissue engineering: In – vitro...... 2285 M.T. Khorasani, H. Mirzadeh, A. Talebi, S. Irani Finite Element Analysis of Bone Remodeling after Hip Resurfacing Arthroplasty ...... 2288 Bernd-Arno Behrens, Ingo Nolte, Patrick Wefstaedt, Christina Stukenborg-Colsman, Anas Bouguecha

Innovations and Nanotechnology

Systems in Foil – Opening new Perspectives in Medical Technology...... 2292 F.P. Wieringa, G.T. van Heck, P. Rensing, M.M. Koetse, S.S. Kalisingh and H. Schoo Silicon Surface Modification with Supported Phospholipids Bilayer for Biosensor based on Imaging Ellipsometry ...... 2296 Y.Y. Chen, Z.H. Wang, Y. Liu, W. Liang, W.R. Chang, G. Jin Monitoring Biomolecular Interaction with 1-D Plasmonic Nanostructure by Using Dark Field Microscopy ...... 2300 Hui-Hisn Lu, Chii-Wann Lin, Yueh-Yuan Fang, Tzu-Chien Hsiao, Su-Ming Hsu

Magnetic Nanoparticles

Development of iron oxide nanoparticles for hyperthermia and drug targeting...... 2304 M. Zeisberger, S. Dutz, R. Müller Optimization of magnetic drug targeting by mathematical modeling and simulation of magnetic fields ...... 2309 I. Slabu, A. Röth, T. Schmitz-Rode and M. Baumann A Spectrometer for Magnetic Particle Imaging...... 2313 S. Biederer, T. Sattel, T. Knopp, K. Lüdtke-Buzug, B. Gleich, J. Weizenecker, J. Borgert, T.M. Buzug AC susceptometry and magnetorelaxometry for magnetic nanoparticle based biomolecule detection...... 2317 D. Eberbeck, A.P. Astalan, K. Petersson, F. Wiekhorst, C. Bergemann, C. Johansson, U. Steinhoff, H. Richter, A. Krozer, L. Trahms Breath Synchronous Magnetic Drug Targeting in the Lungs...... 2322 Ch. Dahmani, S. Götz, Th. Weyh, R. Renner, M. Rosenecker, C. Rudolph Content XLIII

Quantification of magnetic nanoparticle concentration in pig lung tissue after magnetic aerosol drug targeting by magnetorelaxometry ...... 2326 F. Wiekhorst, U. Steinhoff, D. Eberbeck, K. Schwarz, H. Richter, R. Renner, M. Roessner, C. Rudolphand L. Trahms Optical fiber sensors for medical applications – Practical engineering considerations...... 2330 J.A.C. Heijmans, L.K. Cheng, F.P. Wieringa Drug delivery by nanoparticles – facing the obstacles...... 2335 M. Löbler, H.W. Rohm, K.-P. Schmitz, A.H. Johnston, T.A. Newman, S. Ranjan, R. Sood, P.K.J. Kinnunen Suitability of Nanoparticles for Stent Application...... 2339 F. Luderer, K. Sternberg, H.W. Rohm, M. Löbler, C. Schultze, K. Köck, H.K. Kroemer and K.-P. Schmitz

Preparation and Characterization of Dextran-Covered Fe3O4 Nanoparticles for Magnetic Particle Imaging...... 2343 Kerstin Lüdtke-Buzug, Sven Biederer, Timo Sattel, Tobias Knopp and Thorsten M. Buzug Localization of a magnetic nanoparticle spot from features of the magnetic field pattern and comparison to a magnetic dipole fit ...... 2347 F. Wiekhorst, U. Steinhoff, W. Haberkorn, G. Lindner, M. Bär and L. Trahms

Microsystems

Intraoral Drug Delivery Microsystem ...... 2352 A. Schumacher, T. Goettsche, S. Haeberle, T. Velten, O. Scholz, A. Wolff, B. Beiski, S. Messner and R. Zengerle A miniaturized pressure independent drug delivery system for metronomic cancer therapy...... 2356 F. Goldschmidtboeing, A. Geipel, C. Farhat, P. Jantscheff, N. Esser, U. Massing, P. Woias An Efficient Low-voltage Micropump For An Implantable Sphincter System...... 2360 G. Biancuzzi, T. Lemke, P. Woias, O. Ruthmann, H.J. Schrag, B. Vodermayer, T. Schmid and F. Goldschmidtboeing Integration of microneedle-arrays and micro pumps in disposable and cheap drug delivery devices ...... 2364 M. Vosseler, M. Jugl, M. Blaesing, D. Hradetzky, S. Messner and R. Zengerle Adjustable Diffusion Barrier for Controlled Drug Release in Spastic and Pain Therapy...... 2368 S. Herrlich, S. Ziolek, H. Hoefemann, R. Zengerle and S. Haeberle A Prototype of Miniaturized SPR Sensing System based on Polymer Light-Emitting Diode...... 2372 Yueh-Yuan Fang, Tz-Bin Wang and Chii-Wann Lin Micromanufactured electrodes for cortical field potential recording: in vivo study...... 2375 J.G. Cordeiro, C. Henle, M. Raab, W. Meier, T. Stieglitz, A. Schulze-Bonhage, J. Rickert A Binder-less Glucose Fuel Cell with Improved Chemical Stability Intended as Power Supply for Medical Implants...... 2379 S. Kerzenmacher, U. Kräling, J. Ducrée, R. Zengerle and F. von Stetten Bio-Microsystem for Cell Cultivation and Manipulation and its Peripherals...... 2384 U. Fröber, M. Stubenrauch, D. Voges, M. Hoffmann and H. Witte Electrode Localization in a Self-organizing Network for Electrophysiological Diagnostics ...... 2388 M. Schaefer, C.P. Figueiredo, S. Kiefer, P.M. Mendes, R. Ruff, K.P. Hoffmann A Novel Interconnection Technology for Laser-Structured Platinum Silicone Electrode Arrays ...... 2392 T. Guenther, M. Schuettler, J.S. Ordonez, C. Henle, J. Wilde and T. Stieglitz Fluid characterization by interdigitated electrodes sensors...... 2396 Sylvain Druart, Rémi Pampin, Luis Moreno Hagelsieb, Laurent Francis, Denis Flandre Non-contact Micromanipulation System with Computer Vision ...... 2400 Y. Tanaka, H. Kawada, K. Hirano, M. Ishikawa and H. Kitajima XLIV Content

Progress in the Development of the Artificial Accommodation System ...... 2405 J.A. Nagel, T. Martin, L. Rheinschmitt, U. Gengenbach, G. Bretthauer, R.F. Guthoff

Neural Engineering

Coating of neural microelectrodes with intrinsically conducting polymers as a means to improve their electrochemical properties...... 2409 W. Poppendieck, K.-P. Hoffmann MEMS-Technology for Large-Scale, Multichannel ECoG-Electrode Array Manufacturing ...... 2413 B. Rubehn, P. Fries and T. Stieglitz Integration of Recording channel for the Evoked Compound Action Potential in an Implantable Neurostimulator...... 2417 Pascal Doguet, Thomas Costecalde, Hervé Mével, Jorge Marin Millan² and Jean Delbeke Planar 2D-Array Neural Probe for Deep Brain Stimulation and Recording (DBSR)...... 2421 Silke Musa, Marleen Welkenhuysen, Roeland Huys, Wolfgang Eberle, Kris van Kuyck, Carmen Bartic, Bart Nuttin, Gustaaf Borghs Robust microprobe systems for simultaneous neural recording and drug delivery...... 2426 S. Spieth, A. Schumacher, K. Seidl, K. Hiltmann, S. Haeberle, R. McNamara, J.W. Dalley, S.A. Edgley, P. Ruther and R. Zengerle Integration of Microfluidic Channels into Laser-Fabricated Neural Electrode Arrays ...... 2431 E. Fiedler, M. Schuettler, C. Henle, R. Zengerle, and T. Stieglitz Why are penetrating electrodes for the cochlear nucleus not significantly superior to superficial implants?...... 2435 S.K. Rosahl and S. Rosahl Deposition Parameters Determining Insulation Resistance and Crystallinity of Parylene C in Neural Implant Encapsulation ...... 2439 C. Hassler, R. von Metzen, T. Stieglitz Electric Field Distribution for the Characterization of Planar and Recessed Electrodes...... 2443 T.B. Krueger and T. Stieglitz A Telemetry Platform for Implantable Devices Providing Inductive Energy Supply and a Bi-Directional Data Link...... 2447 C. Jeschke, M. Schuettler, L. Reindl, and T. Stieglitz

Modeling and Simulation

The Influence of Inter-Crystal Scattering on Detection Efficiency of Dedicated Breast Gamma Camera: A Monte Carlo Study ...... 2451 M. Rasouli, M.R. Ay, A. Takavar, S. Lashkari and G. Loudos An Optimised 3D Breast Phantom for X-Ray Breast Imaging Techniques ...... 2455 K. Bliznakova, S. Kazakli and N. Pallikarakis Random walk simulation of R2-dispersion in foam microstructures...... 2459 S.H. Baete and Y. De Deene Imaging haemorrhagic cerebral stroke by frequency-difference magnetic induction tomography: numerical modelling...... 2464 M. Zolgharni, H. Griffiths and D.S. Holder Content XLV

A novel simulation environment for testing experimental and established ultrasonic blood flow imaging techniques...... 2468 Abigail Swillens, Lasse Lovstakken, Hans Torp, Patrick Segers Several Optimization Methods to Optimize the Spacing Between the Elements of Ultrasound linear Phased Array to Produce a Radiation Pattern with Minimum Side Lobes Level (SSL), Null Placement Control and Treating Cancer Tumors in Biological Media ...... 2472 Mazhar B. Taiel, Nour H. Ismail, Ashraf T. Ibrahim Monte Carlo Assessment of Geometric, Scatter and Septal Penetration Components in DST-XLi HEGP Collimator ...... 2479 M. Shafaei, M.R. Ay, D. Sardari, N. Dehestani, H. Zaidi Simulation of Ultrasound Parameter Distribution Influence in Ultrasonic Computed Tomography...... 2483 J. Roleek, D. Hemzal, I. Peterlík and J. Jan Monte Carlo based calculation of patient exposure in X-ray CT-examinations ...... 2487 R. Schmidt, J. Wulff, B. Kästner, D. Jany, J.T. Heverhagen, M. Fiebich and K. Zink Heat transfer analysis software adapted to skin burn depth simulations...... 2491 M.K. Bajorek, M. Kacmarek Changes in the length of the sacrospinous and sacrotuberous ligaments induced by Salter osteotomy: a computer simulation...... 2495 W. Bartels, T. Pressel, S. Max, C. Hurschler and J. Vander Sloten Virtual Stenting for Carotid Stenosis with Elastic Artery Wall Modeling...... 2499 J. Egger, S. Großkopf and B. Freisleben Contact Configuration and Energy Consumption in Spinal Cord Stimulation ...... 2503 C.C. de Vos, M.P. Hilgerink, H.P.J. Buschman and J. Holsheimer Adaption of Mathematical Ion Channel Models to measured data using the Particle Swarm Optimization ...... 2507 G. Seemann, S. Lurz, D.U.J. Keller, D.L. Weiss, E.P. Scholz and O. Dössel Localization of the Origin of Ventricular Premature Beats by Reconstruction of Electrical Sources Using Spatio-Temporal MAP-based Regularization ...... 2511 Y. Jiang, D. Farina and O. Dössel System Identification of Neonatal Incubator based on Adaptive ARMAX Technique ...... 2515 Abbas K. Abbas, Steffen Leonhardt A Convolution-based Methodology to Simulate Cardiac Ultrasound Data Sets: Integration of Realistic Beam Profiles ...... 2520 Hang Gao, Piet Claus, G. Harry van Lenthe, Siegfried Jaecques, Steven Boonen, Georges Van der Perre, Walter Lauriks and Jan D’hooge There is more than biphasic truncated exponential in defibrillation...... 2524 M. Schönegg and A. Bolz Optimization of image quality and patient dose in paediatric radiology using Monte Carlo modeling ...... 2528 P. Penchev, V. Klingmüller, G. Alzen and M. Fiebich Evaluation of Induced Current Densities and SAR in the Human Body by Strong Magnetic Fields around 100 kHz...... 2532 J. Bohnert, B. Gleich, J. Weizenecker, J. Borgert and O. Dössel Pressure waveform estimation in the common carotid artery Different methods in comparison...... 2536 Irene Zaccari, Alessandro C. Rossi, E. Marielle H. Bosboom, Peter J. Brands Parameter estimation of recruitment models in mechanical ventilation ...... 2540 K. Möller, T. Sivenova, H. Runck, C. Stahl, S. Schumann, and J. Guttmann XLVI Content

Time and Memory Efficient Implementation of the Cardiac Bidomain Equations...... 2544 M. Karl, G. Seemann, F.B. Sachse, O. Dössel and V. Heuveline A generic model of overall heart geometry for model based studies of electrical, mechanical, and ion-kinetics aspects of the heart ...... 2548 André C. Linnenbank, Peter M. van Dam, Thom F. Oostendorp, Peter H.M. Bovendeerd, Iris K. Rüssel, Mark Potse Nonlinear Finite Element Analysis of Balloon Sinuplasty ...... 2552 F. Cui, H.P. Lee and D.Y. Wang A mathematical speedup prediction model for parallel vs. sequential programs...... 2556 H.M. Overhoff, S. Bußmann and D. Sandkühler Model-Based Method of Non-Invasive Reconstruction of Ectopic Focus Locations in the Left Ventricle ...... 2560 D. Farina, Y. Jiang, O. Dössel, C. Kaltwasser and W.R. Bauer Engineering Support in Surgical Strategy for Ventriculoplasty ...... 2564 Y. Shiraishi, T. Yambe, Y. Saijo, S. Masuda, G. Takahashi, K. Tabayashi, T. Fujimoto and M. Umezu Simulation-based femoro-popliteal bypass surgery...... 2568 M. Willemet, G. Compère, J.F. Remacle and E. Marchandise An applicability of Impedance Technique in evaluation of cardiac resynchronization therapy ...... 2571 M. Lewandowska, J. Wtorek and L. Mierzejewski Porcine model for CPR artifact generation in ECG signals ...... 2575 A.C. Mendez, M. Roehrich and H. Gilly Design and Assessment of Fuzzy Rules by Multi Criteria Optimization to Classify Anaesthetic Stages...... 2579 R. Baumgart-Schmitt, C. Walther and K. Backhaus Impact of the hERG Channel Mutation N588K on the Electrical Properties of the Human Atrium ...... 2583 P. Carrillo, G. Seemann, E. Scholz, D.L. Weiss and O. Dössel The Effect of Laser Characteristics in the Generation and Propagation of Laser Generated Guided Waves in Layered-skin Model ...... 2587 Adèle L’Etang and Zhihong Huang A Mesh-Based Model for Prediction of Initial Tooth Movement...... 2592 K. De Bondt, A. Van Schepdael, J. Vander Sloten Recipe Suggestion System ...... 2596 Satoshi Morita, Yasuyuki Shimada, Tsutomu Matsumoto, Shigeyasu Kawaji, and Timothy Teo Zhong Hon An Object-oriented Model of the Cardiovascular System with a Focus on Physiological Control Loops...... 2600 A. Brunberg, D. Abel and R. Autschbach Computer Simulations of a Blood Flow Behavior in Simplified Stenotic Artery Subjected to Strong Non-Uniform Magnetic Fields ...... 2604 S. Kenjeres and R. Opdam A Multiphysics Model for Studying the Influence of Pulse Repetition Frequency on Tissue Heating During Electrochemotherapy ...... 2609 I. Lackovi, R. Magjarevi and D. Miklavi Transient Simulation of the Blood Flow in the thoracic Aorta based on MRI-Data by Fluid-Structure-Interaction...... 2614 Dipl.-Ing. Markus Bongert, Prof. Dr.-Ing. Marius Geller, Dr. med. Werner Pennekamp, Dr. med. Daniela Roggenland, Prof. Dr. med. Volkmar Nicolas Micro-gripping of Small Scale Tissues...... 2619 R.E. Mackay, H.R. Le, K. Donnelly and R.P. Keatch Content XLVII

Optimizing drug delivery using non-uniform magnetic fields: a numerical study ...... 2623 J.W. Haverkort and S. Kenjereš A real bicycle simulator in a virtual reality environment: the FIVIS project...... 2628 O. Schulzyk, U. Hartmann, J. Bongartz, T. Bildhauer, R. Herpers Influence of body worn wireless mobile devices on implanted cardiac pacemakers ...... 2632 Sebastian Seitz and Olaf Dössel Co-simulation approach for the design of MRI RF coils and its application to local SAR distribution...... 2636 Sylvia Smajic-Peimann and Waldemar Zylka Effect Of Prism Induced Heterophoria On Binocular Visual Evoked Potential...... 2640 S.M. Shushtarian, A. Norouzi Experimental and Numerical Flow Modeling towards Refinement of Three-dimensional Echocardiography for Heart Valve Leakage Quantification ...... 2644 P. Van Ransbeeck, M. Vermeulen, B. Van Der Smissen, F. Maes, R. Kaminsky, T. Claessens, P. Segers and P. Verdonck A Model for the Regulation of the Ca2+ in the neuronal cell...... 2648 C.M. Dabu Mathematical modeling of fracture healing: coupling between mechanics, angiogenesis and osteogenesis...... 2651 L. Geris, J. Vander Sloten and H. Van Oosterwyck Numerical Study of Effects of Bladder Filling on Prostate Positioning In Radiotherapy...... 2655 J. Krywonos, F. Elkut, J. Brunt, Z. Malik, C. Eswar, J. Fenwick and X.J. Ren Time course of electrical and diffusional parameters during and after electroporation...... 2659 D. Miklavcic and L. Towhidi Multivariate Calibration Models to Estimate Non-invasively Blood Glucose Levels Based on A Novel Optical Technique Named Pulse Glucometry ...... 2664 Yasuhiro Yamakoshi, Mitsuhiro Ogawa, Takehiro Yamakoshi, Toshiyo Tamura and Ken-ichi Yamakoshi Functional analysis of Normal and CSNB a-wave ERG component...... 2668 R. Barraco, L. Bellomonte, M. Brai and D. Persano Adorno Temperature distribution assessment during radiofrequency ablation...... 2672 G. Tato, T. Rok, E. Rokita Numerical Modeling of Perfusion Flow in Irregular Scaffolds ...... 2677 P. Van Ransbeeck, F. Maes, S. Impens, H. Van Oosterwyck and P. Verdonck Return Time of Heart Dynamics ...... 2681 F. Ariaei, E.A. Jonckheere, W.P. Stuppy and T.S. Callahan How to shift the human sleep-wake cycle: a simulation study incorporating monochromatic blue light...... 2686 C. Heinze, S. Schirmer, M. Golz Benchmarking Different Models describing Sinus Node Heterogeneity...... 2691 M. Wilhelms, G. Seemann and O. Dössel A Computational Modeling Study of the Effects of Acoustic Trauma on the Dorsal Cochlear Nucleus...... 2695 X. Zheng, A. Giang, S. Vetsis, I.C. Bruce, and H.F. Voigt It Takes Two to Tango: Regulation of Sarcoplasmic Reticulum Calcium ATPase by CaMK and PKA in a Mouse Cardiac Myocyte ...... 2699 J.T. Koivumäki, T. Korhonen, J. Takalo, M. Weckström and P. Tavi Reconstruction of Ectopic Foci Using the Critical Point Theory...... 2703 V. Reimund, D. Farina, Y. Jiang and O. Dössel XLVIII Content

Education and Profession

An Non-traditional Career Evolution: Replacing the Leaders...... 2707 Professor Gabriela Marinescu, Ph. D. The role of biomedical engineers in systems / synthetic biology...... 2714 J.A. Crowe Cooperative Education Program in Medical Equipment Technology Education...... 2718 A. Alhamwi, T. Elsarnagawy Sustainable System Understanding & Empathic Product Design – A Custom-Built Qualification Concept for Biomedical Engineers...... 2722 I. Marsolek, D. Fuchs, W. Friesdorf, O. Bergmann and D. Pappert By legislation driven BME curriculum at VSB TU Ostrava...... 2726 J. Cernohorsky, H. Sochorova Assistive Technologies: New Challenges for Education ...... 2730 M. Klima, L. Lhotska, V. Chudacek, M. Huptych and M. Husak B-AEHS: a formal model for Adaptive Educational Hypermedia System in a Biomedical Project Evaluation...... 2734 M.A.F. Almeida and F.M. de Azevedo EVICAB - Biomedical Engineering Program on the Internet including Video Files for iPod...... 2738 J.A. Malmivuo, A. Kybartaite and J.J. Nousiainen Current Status of Biomedical Engineering Education Programs in Austria ...... 2742 J. Schröttner BME master studies as project-oriented learning at CTU Prague...... 2746 V. Rogalewicz and M. Vrbová Dual Education in Biomedical Engineering at Berufsakademie Sachsen...... 2749 T. Schmitt, E. Uffrecht Assessing the educational status of clinicians concerning mechanical ventilation...... 2753 D. Gottlieb, S. Lozano, J. Arntz, J. Guttmann and K. Möller TheraGnosos: an Interactive Blended Learning, Simulation and Training System for Biomedical Engineering University Courses...... 2757 U. Morgenstern, A. Abdel-Haq, V. Barth, H. Dietrich, I. Rudolph Biomedical Engineering Education: New Curricula, New Experience...... 2760 L. Lhotska Using Open Structure Database for Teaching Designing Health Information System ...... 2764 I. Patasiene, M. Patasius and R. Kregzdyte Curriculum of Bachelor Studies - Biomedical Technician at the Czech Technical University...... 2768 J. Charfreitag and J. Hozman Design and Development of Virtual Scenes using 3D models for Computer-Assisted Learning...... 2772 L. Colmenares, A. Bosnjak, G. Montilla, H. Villegas, I. Jara

Author Index...... 2777

Subject Index ...... 2793