Cardiac Arrhythmias CORE A1 brought to you by by you to brought Elsevier - Publisher Connector Connector - Publisher Elsevier by provided ABSTRACTS: Cardiac Arrhythmias Cardiac ABSTRACTS: Fragmented QRS Predicts Mortality QRS Predicts with Fragmented in Patients Systolic Heart Failure of EKG’s? Can MRI Shed Insight into the Accuracy of QTc IntervalPrevalence Prolongation in Patients Admitted to Cardiac Critical Care Units and of Subsequent Administration of QT Frequency Interval Drugs Prolonging ARRHYTHMIAS - 12:00 p.m. 10:30 a.m. 2010, March 15, Monday, Room B404 Congress Center, Georgia World CME/CE Hours: 1.5 Mechanical Dispersion Right Ventricular with in Patients Predicts Malignant Arrhythmias Cardiomyopathy Right Ventricular Arrhythmogenic for Viral and CD4+ Cell Count as Risk Factors Load Prolonged QTc Interval Subjects: A in HIV-infected Cohort-Nested Case-Control Study in an Outpatient Population Ashraf Y. QaQa, Hamid S. Shaaban, Vincent A. DeBari, Susan Vincent DeBari, A. Hamid S. Shaaban, QaQa, Ashraf Y. Michael’s Saint Shamoon, Fayez George Perez, Jihad Slim, Phung, NJ Newark, Medical Center /Seton Hall University, Learning CD+ cell count and viral load Objective: Demonestrate that are independent risk factors in HIV poistive for QTc prolongation outpatient population. 11:00 Mithilesh K. Das, Julie M. Clary, Prem Konakondla, Vikas Kalra, IN Indianapolis, Indiana University, Learning fragmented QRS complex Objective: Demonstrate that predicts increased mortality in patients with systolic heart failure. 11:15 The Robert The Center for CVMRI, WW Biederman, Nadour, Wadih General Institute at Allegheny Gerald McGinnis Cardiovascular PA Pittsburgh, Hospital, basis of the learn that the electrophysiologic Learning Objective: To CMR infarct imaging is variably accurate when depicted by Q-wave 11:30 Brian R. Joanna R. Kingery, James E. Tisdale, Heather A. Wroblewski, IN Lafayette, West Purdue University, Richard J. Kovacs, Overholser, Learning of administration of QTc Objective: Identify prevelance prolonging medications in vulnerable populations 906 CARDIAC OF PREDICTORS NONINVASIVE 10:30 Otto Ole-Gunnar Anfinsen, H. Haugaa, Sebastian I. Sarvari, Kristina Oslo University Hospital, Thor Edvardsen, Amlie, Jan P. A. Smiseth, Oslo, Rikshospitalet, risk for pasients with increased Learning Identify ARVC Objective: right ventricular dispersion assessing by by ventricular arrhythmias strain echocardiography. 10:45 ORAL CONTRIBUTIONS ORAL Catheter-Based Left Atrial Appendage (LAA) of Embolic Events the Prevention Ligation for Arising from the LAA A Therapeutic Strategy for 2010 to Reduce the A Therapeutic Strategy for Atrial Fibrillation: A Pilot Incidence of Postoperative Study Impact of Dronedarone Started Rapidly after Amiodarone Discontinuation Dabigatran Versus Warfarin in Atrial Fibrillation Warfarin Dabigatran Versus Moderate and High Chads2 with Low, Patients Score: A Re-ly Subgroup Analysis Left Ventricular Hypertrophy and Antiarrhythmic Left Ventricular Drugs Fibrillation: in Atrial Impact on Mortality ADVANCES - 9:30 a.m. 8:00 a.m. 2010, March 15, Monday, Room B404 Congress Center, Georgia World CME/CE Hours: 1.5

Randall J. Lee, Steven J. Yakubov, Krzysztof Bartus, Jacek Bednarek, Krzysztof Bartus, Jacek Bednarek, J. Yakubov, Steven Randall J. Lee, San University of California, Jerzy Sadowski, Kapelak, Boguslaw Riverside Methodist Hospital, CA, San Francisco, Francisco, OH Columbus, Learning catheter based approach for Objective: Evaluate a novel ligation of the left atrial appendage 9:00 Jennifer Shea, Amit Shah, Gurpreet Sodhi, Jennifer Price, Jennifer Price, Gurpreet Sodhi, Amit Shah, Jennifer Shea, University, George Washington Allen J. Solomon, Najam, Farzad DC Washington, Learning strategy Objective: Describe a new to reduce postoperative atrial fibrillation 8:45 Peter R. Kowey, Bramah N. Singh, Stuart J. Connolly, Harry J. Crijns, Stuart Bramah N. Singh, J. Connolly, R. Kowey, Peter Etienne M. Aliot, Radzik, David Alessandro Capucci, Denis Roy, PA Wynnewood, Hospital, Lankenau Stefan H. Hohnloser, Learning Objective: undertand the effects of starting dronedarone after amiodarone discontinuation. 8:30 Jonas Oldgren, Marco Alings, Harald Darius, John Eikelboom, John Eikelboom, Harald Darius, Marco Alings, Jonas Oldgren, Salim Reilly, Paul Janice Pogue, Amit Parekh, Michael Ezekowitz, Uppsala Clinical Research Stuart Connolly, Lars Wallentin, Yusuf, Health Research Institute, Population Sweden, Uppsala, Center, Canada Hamilton, Learning risk profile with dabigatran Objective: Describe the benefit moderate and high risk atrial fibrillation in low, versus warfarin patients 8:15 Roy Chung, Michael Tchou, Mark J. Niebauer, Patrick J. Tchou, J. Tchou, Patrick Mark J. Niebauer, Michael Tchou, Chung, Roy Heart DepartmentMina K. Chung, and Medicine, of Cardiovascular OH Cleveland, Clinic, Cleveland Institute, Vascular drugs the safety of anti-arrhythmic evaluate Learning To Objective: and left ventricular hypertrophy. in patients with atrial fibrillation 8:00 903 THERAPEUTIC - RECENT FIBRILLATION ATRIAL JACC March 9, 2010 2010 9, March JACC View metadata, citation and similar papers at core.ac.uk at papers similar and citation metadata, View Cardiac Arrhythmias atrial fibrillationinAustraliafrom 1998 to2008. Objective: Describerecenttrendsinhospitalizationfor Learning Adelaide, Australia Adelaide, Australia, Discipline ofMedicine, ofAdelaide, University Centre, ofCardiology, Department Royal Adelaide Hospital, Julian Laborderie, PrashanthanSanders, Cardiovascular Research Leong, Nicholas J.Shipp, Muayad Alasady, HanS.Lim, Hany Abed, Christopher X.Wong, DennisH.Lau, Anthony P. G.Brooks, Darryl 1023-125 AFtreatedwithamiodaroneandRAS inihibitors persistent aftercardioversioninpatients with fibrillation recurrences Objective:n-3PUFAsLearning areeffectivetoreduceatrial Italy ofBrescia,of ExperimentalandAppliedMedicine-University Brescia, Nicola Berlinghieri, MihaiGheorghiade, LivioDeiCas, Department Savina Nodari, MarcoTriggiani, AnnaForesti, GiuseppeMilesi, 1023-124 or atrialflutter dronedarone comparedtoplaceboinpatientswithatrialfibrillation Objective:Evauatetheantiarrhythmic efficacyof Learning San Francisco, CA MedicalCenter,Cedars-Sinai LosAngeles, CA, UCSFMedicalCenter, Sanjay Kaul, EugenioCingolani, David Singh, GeorgeA.Diamond, 1023-123 fibrillation arelongerthantheonescalculatedinsinusrhythm Objective:DemonstratethatQTccalculatedinatrial Learning New York, NY Hospitals, CollegeofPhysicians ColumbiaUniversity andSurgeons, Jonathan S.Steinberg, SuneetMittal, St.Luke’s andRoosevelt Dan LaurentiuMusat, Emad F. Aziz, AlexandreBenjo, SonaliMantoo, 1023-121 electrical cardioversion to facilitate electricalcardioversioninpatientswhowere refractory Objective:Describeouruseofranolazineasanagentto Learning Wausau, WI, CaREFoundation, Inc., Wausau, WI Wisconsin,Larrain, CardiovascularS.C., AssociatesofNorthern David K.Murdock, Jeffrey W. Kaliebe,Kersten, Mary German 1023-120 1023 A2 Fibrillation inAustralia: 1998-2008 Fibrillation Increasing Trends inHospitalizationfor Atrial AProspective RandomizedStudy Atrial Fibrillation. Sinus Rhythm AfterConversion fromPersistent Use ofn-3Polyunsaturated Fatty Acids toMaintain Results ofaMeta-analysis. Atrial Fibrillation: Modest Antiarrhythmic EfficacyofDronedarone for Implications for Dofetilide DoseTitration The Effect ofAtrialRhythm ontheQTcInterval: Cardioversion ResistantPatients Ranolazine Facilitates ElectricalCardioversionin 1 CME/CE Hours: 9:30a.m.-10:30 Presentation Hour: Georgia World CongressCenter, HallB5 Sunday, March14, 2010, 9:30a.m.-12:30p.m. SUPRAVENTRICULAR ARRHYTHMIAS CLINICAL ELECTROPHYSIOLOGY-- ABSTRACTS: Cardiac Arrhythmias POSTER CONTRIBUTIONS 1024-129 1024 activity. andarrhythmicglycosides-induced intracellularcalciumoverload mediated stimulationoflatesodiumcurrent, cardiac thatunderlies Objective:IdentifyanovelLearning mechanism, i.e.aCaMKII- ofFlorida,University Gainesville, FL, GileadSciences, Palo Alto, CA Yejia Song, JohnC.Shryock,Shen-LingXia, LuizBelardinelli, 1023-127 depointes. in ventricularmyocytes torsade intrigerring Objective:DescribetheroleofintracellularCaoscillations Learning Pittsburgh, Pittsburgh, PA Jan Nemec, JongKim, Bethanny Gabris, GuySalama, of University 1023-126 Optimization ofRV pacinginRBBBpatients Objective: EvaluateHemodynamicEffectandAVLearning of SouthCarolina, Charleston, SC Marcus Wharton,YinghongYu, MichaelR.Gold, MedicalUniversity J. LacySturdivant, JiangDing, Frank Cuoco,B.Leman, Robert J 1024-131 position andresponsetoCRT Objective:ToLearning therelationshipofLV understand lead , Hospital, Papworth Cambridge, UnitedKingdom Simon P. Fynn, David P. Dutka, Addenbrooke’s Hospital, Cambridge, Fakhar Z.Khan, MunmohanS.Virdee, PhilipA.Read, Peter J.Pugh, 1024-130 Optimization ofLV andBVpacing Objective:EvaluateHemodynamicEffectandAVLearning South Carolina, Charleston, SC J LacySturdivant, Michael Kim, YinghongYu, of MedicalUniversity Gold,Michael Robert ImranNiazi, MichaelGiudici,Leman, Robert Delay the AcuteHemodynamicResponseandOptimalAV Therapy:Cardiac Resynchrnoization Comparisonof LeftVentricularBiventricular versus Pacing for 1 CME/CE Hours: 9:30a.m.-10:30 Presentation Hour: Georgia World CongressCenter, HallB5 Sunday, March14, 2010, 9:30a.m.-12:30p.m. PACING EFFECT OFLEADPLACEMENT ONCARDIAC Ca byOuabain IncreasesLateSodiumCurrent a A RabbitModelOfLongQTType 2(LQT2) Lability (TWL)PrecedeTorsade DePointes (TdP)In Intracellular Ca2+(Cai)OscillationsandT-wave and OptimizationoftheAV Delay with RBBB:Effects onRV HemodynamicFunction Right Ventricular Failure Pacing Patients inHeart Therapy: HowCloseDoYou NeedtoBe? Activation andResponsetoCardiacResynchronization Ventricular LeadPositions totheLatestSiteof The Relationshipbetween theProximityofLeft 2+ /Calmodulin Kinase-MediatedMechanism JACC March 9, 2010 Cardiac Arrhythmias A3 ABSTRACTS: Cardiac Arrhythmias Cardiac ABSTRACTS: Effect of Left Axis Deviation on Cardiac on Cardiac of Left Axis Deviation Effect Response in Patients Resynchronization Therapy With Left Bundle Branch Block THERAPY RESYNCHRONIZATION CARDIAC 9:30 a.m. - 12:30 p.m. 2010, March 14, Sunday, Hall B5 Congress Center, Georgia World Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 with Patients for Cardiac Resynchronization Therapy Heart and Chronic Atrial fibrillation. Failure Survival Resynchronization Benefit from Cardiac with Borderline Duration QRS in Patients Therapy Etiology In Patients Of A Vasodepressor Persistence Pacemakers. Permanent With Bradycardia And And Role Of The ClS Mechanism Of The Response Outcome Sensor In Improving On 12- The Absence of Left Bundle Branch Block Response and Increased lead ECG Predicts Poor Mortality Undergoing Resynchronization in Patients Therapy Hicham Z. El Masry, Julie M. Clary, Ahmad Alqaqa’a, Mithilesh K. Ahmad Alqaqa’a, Julie M. Clary, Hicham Z. El Masry, IN Indianapolis, University, Indiana Das, Learning on baseline ECG in Objective: The abscence of LBBB is therapy patients who are candidates to cardiac resynchronization a predictor of worse response to CRT. prognosis and poor 1025-143 Aryan N. Chandra N. Nair, Siva Soma, Shen, Xuedong Madhu Reddy, NE Omaha, University, Creighton Mooss, Learning on of left axis deviation Objective: Identify the effect with left response in patients cardiac resynchronization therapy bundle brach block. 1026 1026-146 Doi, Takahiro Nakao, Tetsushi Satoshi Shizuta, MAMORU HAYANO, Nobuyoshi, Masakiyo Arita, Takeshi Andou, Kenji Kimura, Takeshi University Graduate Kyoto Isshiki, Takaaki Inoue, Koichi Satoki Fujii, Kyoto, School of Medicine, 1025-140 Stephanie Hidekazu Tanaka, Phillip Habib, Olusegun Oyenuga, III, John Gorcsan, Samir Saba, Evan C. Adelstein, C. Haberman, PA Pittsburgh, University Of Pittsburgh, Learning Demonstrate that survival Objective: CRT following QRS duration be similar in patients with wide implantation may echocardiographic and borderline selected by QRS patients indices. dyssynchrony 1025-141 NJ Passaic, St Marys Hospital, Pranesh Thirukkonda, Atul Prakash, Learning Understand Objective: in the role of contractility Neurocardiogenic Syncope 1025-142 Recovery Nodal Function of Atrioventricular High Grade Placement for After Pacemaker Surgery Block After Valve Atrioventricular ON CARDIAC PACING ON CARDIAC 9:30 a.m. - 12:30 p.m. 2010, March 14, Sunday, Hall B5 Congress Center, Georgia World Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Right Ventricular Outflow Tract Pacing Brings Tract Outflow Right Ventricular Output in comparison with Mid- Cardiac Favorable ventricular or Apical Pacing Effect of Biventricular and Right Ventricular Pacing Pacing of Biventricular and Right Ventricular Effect on Coronary Flow Reserve in Responders and Non- Responders to Cardiac Resynchronization Therapy The Impact of Right Ventricular Lead Position on Lead Position Ventricular The Impact of Right Resynchronisation Therapy Response to Cardiac Concordant and Discordant Left with in Patients Leads Ventricular Alterations In The Expression Of Genes Related To Genes Related To In The Expression Of Alterations Function And HypertrophyContractile Of The Left The From Patients Paced In Chronically Ventricle (preliminary Apex Results) Right Ventricular Ashwani Sastry, A. Garvey Rene, James Horowitz, George Thomas, Thomas, George James Horowitz, A. Garvey Rene, Sastry, Ashwani Weill M. Markowitz, Steven Bruce B. Lerman, Liu, Christopher F. NY York, New Medical College of Cornell University, block in Learning of long-term Objective: Describe the prevalence AV dysfunction after valve patients undergoing PPM implantation for AV surgery. 1025-138 1025 EFFECT PARAMETERS ELECTROCARDIOGRAPHIC Yasutaka Hirayama, Hokkaido Cardiovascular Hospital, Sapporo, Sapporo, Hospital, Hokkaido Cardiovascular Hirayama, Yasutaka Japan Asahikawa, Medical College, Asahikawa Japan, in Learning Objective: know the beneficial effect of RVOT and RVMS. comparison with RVAP 1024-136 Spyridon Deftereos, Georgios Giannopoulos, Charalambos Georgios Giannopoulos, Deftereos, Spyridon Olga Panagopoulou, Vasiliki Raisakis, Konstantinos Kossyvakis, Athens General Vlasios Pyrgakis, Andreas Theodorakis, Ntzouvara, Greece Athens, Hospital “G. Gennimatas”, Learning the effect of CRT on coronary Objective: evaluata flow reserve 1024-135 Fakhar Z. Khan, Pegah Salahshouri, Munmohan S. Virdee, Peter J. Peter Munmohan S. Virdee, Salahshouri, Pegah Z. Khan, Fakhar Addenbrooke’s Dutka, P. David Fynn, Simon P. A. Read, Philip Pugh, Papworth Hospital, United Kingdom, Cambridge, Hospital, United Kingdom Cambridge, lead position Learningimpact of th RV Objective: to undestand the on CRT response 1024-133 Emmanuel N. Simantirakis, Joanna E. Kontaraki, Eva G. Joanna E. Kontaraki, N. Simantirakis, Emmanuel Alexandros I. Chrysostomakis, Eva G. Nyktari, Stavros Arkolaki, Heraklion University Hospital, E. Vardas, Panos Patrianakos, P. Greece Heraklion, Learning to comprehend that alterations in the Objective: left ventricular contractile function expression of genes regulating before even at an earlierand hypertrophy are evident stage, impairment functi of ventricular 1024-132 JACC March 9, 2010 2010 9, March JACC Cardiac Arrhythmias Learning Objective: demonstrate Learning Medical Center, Leiden, TheNetherlands E. vanderWall, J.Schalij, Martin JeroenJ.Bax, LeidenUniversity Nico RLvandeVeire, ClaudiaYpenburg, EduardR.Holman, Ernst Ng, C.JanWillemBorleffs, NinaAjmoneMarsan, GaetanoNucifora, Delgado,Victoria RutgerJ.vanBommel, MatteoBertini,CTArnold 1026-153 of patientsafterCRT survival long term Objective:demonstratethatgender does notaffectthe Learning Pittsburgh, Pittsburgh, PA Olusegun Oyenuga, PhillipHabib, JohnGorcsan, III, of University Stephanie C.Haberman, EvanC.Adelstein, HidekazuTanaka, 1026-152 clinicaloutcomesthanpatientswithoutimprovementterm ofMR. regurgitation aftercardiacresynchronizationtherapy hadbetterlong patientswithimprovement Objective:Understand ofmitral Learning Investigators, Kokura MemorialHospital, Kitakyushu, Japan Takeshi Kimura, Takaaki Isshiki, MasakiyoNobuyoshi, Cubic Kenji Ando, SatoshiShizuta, Takeshi Arita, RikiFujii, Kouichi Inoue, 1026-150 inpatientswithCRT electrocardiographic parameters Objective:Identifygenderdifferencesin Learning Clinic, Cleveland, OH Dat Nguyen, MaheshManne, NirajVarma, Patrick Tchou, Cleveland 1026-149 response fromcardiacresynchronizationtherapy. Objective:IdentifypatientslikelyLearning toderivethemost Eileen Hsich, Cleveland Clinic, Cleveland, OH Richard Grimm, WilsonH.Tang, David O. L.Wilkoff, Martin,Bruce Jack Rickard, EiranZ.Gorodeski, Baranowski, Bryan DanielSraow, 1026-148 to changesinLV functionafterCRT Objective:definechangesincerebralbloodflowrelation Learning Leiden, TheNetherlands J.Schalij,Martin JeroenJ.Bax, MedicalCenter, LeidenUniversity Delgado, CarelJWBorleffs, ClaudiaYpenburg, MatteoBertini, Rutger vanBommel, NinaAjmoneMarsan, HilleKoppen, Victoria 1026-147 A4 Cardiac ResynchronizationTherapy Failure Patients ofIschemicHeart Predictors After Survival Long-term Position andMyocardialScar: Left Ventricular Dyssynchrony, LeftVentricular Lead Patient Characteristics Resynchronization Therapy DespiteDifferences in Following Cardiac Gender SimilaritiesinSurvival Undergoing CardiacResynchronizationTherapy. on LongTerm ClinicalOutcomesinPatients The ImpactofImprovement ofMitralRegurgitation Resynchronization Therapy Failure Patientsin Heart WithCardiac Characteristics andLeftVentricular Remodeling Gender Differences inSurfaceElectrocardiographic Cardiac ResynchronizationTherapy Predictor ofResponseinPatients Undergoing Pre-Implant LeftVentricular DilationIsanImportant Cerebral BloodFlow The Effect ofCardiacResynchronizationTherapy on ABSTRACTS: Cardiac Arrhythmias fibrillation system inassessingthromboembolicriskpatientwithatrial Objective:DescribethelimitationofCHADS2scoring Learning L. Klein, Cleveland ClinicFoundation, Cleveland, OH Lindsey, Andrew Zurick, Kevin Shrestha, Wai HongWilsonTang, Allan Hirad Yarmohammadi, Tristan Klosterman, BrandonVarr, Bruce 1078-121 on theeffectivenessofDabigatran theimpactofageandrenalfunction Objective:Understand Learning Hamilton, ON, Canada S. Lewis, EllisonThemeles, SalimYusuf, McMasterUniversity, Ezekowitz, J.Connolly, Stuart Paul Reilly, CameronD. Joyner, Basil Jeff S.Healey, JohnEikelboom, Wallentin, Lars MichaelD. 1078-120 1078 CLINICAL ELECTROPHYSIOLOGY-- fibrillation compared towarfarin inpatientsundergoingcardioversion foratrial Objective:Evaluatethesafetyandefficacy ofdabigatran Learning Hamilton, ON, Canada Institute, andHamiltonHealthSciences, McMasterUniversity Medical Research, Wynnewood, PA, Population HealthResearch C.Flaker,Gregory MichaelD. Ezekowitz, Lankenau Institutefor Paul A.Reilly, SalimYusuf, RangadhamNagarakanti, JanicePogue, Meghashyam J.Koti, AmitParekh, J.Connolly, Stuart Wallentin, Lars 1078-124 nonvalvular atrialfibrillation an oraldirectthrombininhibitor, onthromboembolicevents in appendage occlusionby WATCHMAN dabigatran, device versus Objective:Indirectlycomparetheeffectofleftatrial Learning Diamond, MedicalCenter, Cedars-Sinai LosAngeles, CA Sanjay Kaul, EugenioCingolani, MichaelShehata, GeorgeA. 1078-123 3000 Studies of ThromboembolicRisk:10-Year ofOver Survey Efficiency ofCHADS2ScoringSysteminPrediction Study Compared toWarfarin: AnAnalysisfromtheRE-LY of Stroke andMajorBleeding withDabigatran Effect ofAgeandRenalFunctionontheRisks 1 CME/CE Hours: 3:30p.m.-4:30 Presentation Hour: Georgia World CongressCenter, HallB5 Sunday, March14, 2010, 1:30p.m.-4:30 SUPRAVENTRICULAR ARRHYTHMIAS Cardioversion -AnAnalysisOfPatientsFibrillation Undergoing Dabigatran Versus Warfarin InPatients WithAtrial Nonvalvular AtrialFibrillation? Reducing ThromboembolicEventsinPatients with the WATCHMAN Device ComparetoDabigatranfor How DoesLeftAtrialAppendageOcclusionUsing JACC March 9, 2010 Cardiac Arrhythmias A5 ABSTRACTS: Cardiac Arrhythmias Cardiac ABSTRACTS: Atrial Fibrillation Ablation-Induced Scar with Left Atrial Debulking Does Not Hinder the Reverse Remodeling of Left Atrium Reverse of Left Atrium After Catheter Remodeling Ablation of Atrial Fibrillation in Early and Advanced Stages of Left Atrial Structural Remodeling by Enhancement-MRI Delayed Cryoballoon of Paroxysmal Ablation Atrial Fibrillation Intracardiac Guided by a Prediction of Acute Success by Echocardiography: Non-Fluoroscopic Imaging Technique Mechanistic Insights, Results of Catheter Ablation, Ablation, Results of Catheter Insights, Mechanistic after Atrial Tachycardia for and Risk Factors Atrial Fibrillation:Ablation of Ostial Pulmonary Pulmonary Circumferential Veins Ablation, Veins Ablation Ganglionated Plexi Ablation and and StructuralThe Impact of Electrical Remodeling Undergoing Catheter on Outcomes in Patients Fibrillation Atrial Ablation of Persistent 1079-133 Nathan Burgon, Akoum, Nazem Badger, Troy Suman Kuppahally, Salt University of Utah, Marrouche, Nassir F. Eugene Kholmovski, UT City, Lake Learning atrial fibrillation ablation scar Objective: Demonstrate that does not hinder the reverse remodeling of left atrium 1079-135 Nathan S. Badger, Troy Akoum, Nazem Suman Kuppahally, Eugene Rob MacLeod, Thomas S. Haslam, Parker, Dennis Burgon, University of Utah, Marrouche, Nassir F. Chris McGann, Kholmovski, UT City, Salt Lake Learning Objective: Demonstrate reverse remodeling of left atrium after catheter ablation of atrial fibrillation 1079-136 Bogdan G. Klaus J. Gutleben, Johannes Heintze, Georg Nölker, Jürgen Vogt, Dieter Horstkotte, Pütz, Vanessa Ameera Yalda, Muntean, Heart and Diabetes Center NorthDepartment Rhine- of Cardiology, Bad Oeynhausen, Ruhr University Bochum, Westphalia, Learning Objective: describe how to identify cryo balloon pulmonary vein occlusion 1079-131 Pavel Artemenko, Sergey Alexander Romanov, Pokushalov, Evgeny of State Research Institute Alex Turov, Shirokova, Nataliya Shugaev, Federation Russian Novosibirsk, Circulation Pathology, allow us to assume that the Learning These discoveries Objective: be related with the complex anatomy gap may location of the AT linear lesions by prevented can be of AT of the LA and most cases limitation 1079-132 Matthew Eric Good, Hakan Oral, Amir B. Rabbani, Yoshida, Kentaro Sreedhar Billakanty, Srikar Veerareddy, Thomas Crawford, Ebinger, Fred Bogun, Frank Pelosi, Frank Krit Jongnarangsin, S. Wong, Wai MI Ann Arbor, University of Michigan, Aman Chugh, Morady, LearningAF frequency is a more robust Objective: demonstrate that predictor of long-term ablation of persistent outcome after catheter AF as compared to LA volume. Women Have a Higher Complication Rate When Have Women Atrial FibrillationUndergoing Ablation for SUPRAVENTRICULAR ARRHYTHMIAS SUPRAVENTRICULAR 1:30 p.m. - 4:30 p.m. 2010, March 14, Sunday, Hall B5 Congress Center, Georgia World Presentation Hour: p.m. - 4:30 p.m. 3:30 CME/CE Hours: 1 Risk of Esophageal Injury in a standardized Ablation Cohort Atrial Fibrillation undergoing Ablation Cardiac Phenotyping the TASK-1 Deficient Mouse Cardiac Phenotyping the TASK-1 Calcium Overload is Potentially the Main Cause of the Main Cause Calcium Overload is Potentially with Infecting Death after Heavily Cardiomyocyte Adv-hHCN4 Zasp1-D117N On Z-line Decreases HNav1.5 HNav1.5 On Z-line Decreases Zasp1-D117N Conduction A Dcm Subject With Function In Disturbances 1079-130 Paruchuri, VijayaPraveena Garikipati, Naga Vamsi Arshad, Aysha and St. Luke’s S. Steinberg, Jonathan Suneet Mittal, Avula, Akshay NY York, New Hospitals, Roosevelt Learning Objective: Gender differences in AF ablation outcomes Martin Martinek, Christian Meyer, Said Hassanein, Rainer Schoefl, Rainer Schoefl, Said Hassanein, Martin Martinek, Christian Meyer, University Elisabethinen Helmut Purerfellner, Hans-Joachim Nesser, Austria Linz, Hospital, Teaching Learning Objective: Identify patients at higher risk for esophageal injury during radiofrequency ablation of atrial fibrillation. 1079-129 CLINICAL ELECTROPHYSIOLOGY-- 1079 CLINICAL Birgit C. Donner, Martina Schullenberg, Ulrich Decking, William Martina Decking, Ulrich Schullenberg, Birgit C. Donner, Department Cardiology, G. Schmidt, of Pediatric Klaus Wisden, United London, Imperial College London, Germany, Duesseldorf, Kingdom deficiency on Learning of TASK-1 Objective: distinguish the effect measuring detected by repolarisation of the cardiac action potential surface ECGs. monophasic action potential duration and analyzing 1078-127 Yong-Fu Xiao, Alena Nikolskaya, Lepeng Zeng, Xiaohong Qiu, Qiu, Xiaohong Lepeng Zeng, Alena Nikolskaya, Xiao, Yong-Fu Inc., Medtronic, Daniel C. Sigg, Vinod Sharma, Deborah A. Jaye, MN Mounds View, in Learning hHCN4 overexpression Objective: Demonstrate that but may activities, biopacemaker creates cultured cardiomyocytes cause cell death. Adding specific channel inhibitors the can prevent toxicity. 1078-126 Yutao Xi, Tomohiko AI, Zhaohui Li, Geru Wu, Enkhsaikhan Purevjav, Enkhsaikhan Purevjav, Geru Wu, Li, Zhaohui AI, Tomohiko Xi, Yutao Electrophysiology Matteo Vatta, Cheng, Jie Shahrzad Abbasi, Episcopal Heart Luke’s Institute/St. Texas Research Laboratory, Children’s Texas Cardiology, Pediatric TX, Hoston, Hospital, TX Houston, College of Medicine, Hospital/Baylor Learning elucidate the role of ZASP1-D117N in Objective: in which is critically involved sodium channel, regulating the cardiac conduction system diseases. 1078-125 JACC March 9, 2010 2010 9, March JACC Cardiac Arrhythmias from preablation cardiac CTscanmeasurements veinisolationcanbepredicted veinduringpulmonary pulmonary Objective: describehowfarfieldpotentialsinleftsuperior Learning Kansas City, KS Hospital, KansasCity, KS, ofKansasMedicalCenter, University Buddhadeb Dawn, Dhanunjaya Lakkireddy, ofKansas University Guda, Mike Feldkamp, ThomasRosamond, JamesL.Vacek, Subba ReddyVanga, MazdaBiria, Jayasree Pillarisetti, Rajeshwar 1080-142 with atrialfibrillation contrast cardiacMRIforevaluation ofatrialthrombusinpatients Objective:Demostratetheuseofnon-contrast and Learning Institute atAllegheny GeneralHospital, Pittsburgh, PA Rathi, TheCenterforCVMRI, TheGeraldMcGinnisCardiovascular B. Williams, Doyle, Mark SaundraGrant, Sandeep Anreddy, K. Vikas Sukhraj Balhan,WWBiederman, JuneA.Yamrozik, Robert Ronald 1080-141 maintenanceofsinusrhythmlong-term in71.9%ofcases. in23.6%and ablation inchronicAFleadstoacutetermination Objective:WeLearning demonstratedthatganglionatedplexi Institute ofCirculationPathology, Novosibirsk, Russian Federation Shugaev, Shabanov, Vitaliy AlexTurov, Nataliya Shirokova, StateResearch Evgeny Pokushalov, Alexander Romanov, Sergey Artemenko, Pavel 1080-140 Objective:UsinganovelLearning ablationsystemforatrialfibrillation Cologne, Germany Wolfgang Meuser, Dong-InShin, CenterCologne, AcademicHeart Kathrin Bünz, Pässler, Markus BeatrixReinartz,RainerLehmann, Thomas Deneke, MarcHorlitz, RonHaberkorn, AnnelyBastian, 1080-138 vein isolation Objective:minimizeradiationexposureduringpulmonary Learning Westphalia, Bochum, RuhrUniversity BadOeynhausen, Germany ofCardiology, Rhine- Department andDiabetesCenterNorth Heart Ameera Yalda, Vanessa Pütz, DieterHorstkotte, JürgenVogt, Georg Nölker, KlausJ.Gutleben, JohannesHeintze, JürgenHomberger, 1080-137 1080 CLINICAL ELECTROPHYSIOLOGY-- A6 Does ProximityMatter? VeinMimicking LeftSuperiorPulmonary Potentials: Left AtrialAppendageFar Potentials Field Vein for AStrategy Pulmonary Isolation Fibrillation: of LeftAtrialAppendageThrombusin Transesophageal EchocardiograminEvaluation Cardiovascular MRIisEquallyEffective as Fibrillation Ganglionated PlexiAblationfor ChronicAtrial Acute Effects andLong-Term Outcomeof 100 ConsecutivePatients on -Single-CenterReport Radiofrequency Energy UsingUnipolarandBipolar Fibrillation A Novel CatheterAblationSystemfor Atrial Persistent AtrialFibrillation Fluoroscopy-Free AblationofParoxysmal and 1 CME/CE Hours: 3:30p.m.-4:30 Presentation Hour: Georgia World CongressCenter, HallB5 Sunday, March14, 2010, 1:30p.m.-4:30 SUPRAVENTRICULAR ARRHYTHMIAS ABSTRACTS: Cardiac Arrhythmias 1081-146 1081 CLINICAL ELECTROPHYSIOLOGY-- the impactofdifferentballoonsizes ablationand Objective:evaluate theefficacyofcryoballoon Learning Bochum,University BadOeynhausen, Germany Cardiology, Rhine-Westphalia, andDiabetesCenterNorth Ruhr Heart Ameera Yalda, Vanessa Pütz, DieterHorstkotte, of Department Juergen Vogt, JohannesHeintze, GeorgNölker, KlausJ.Gutleben, 1080-144 antiarrhythmic agentsontheoutcomesofatrialfibrillationablation. Objective:Evaluatetheimpactofperiprocedural Learning Hospital, Baltimore, MD Spragg, HughCalkins, A.Henrikson, Charles TheJohnsHopkins Marine, RonaldD. Berger, SamanNazarian, AlanCheng, David Jonathan W. Dukes, Chilukuri, Karuna DanielScherr, JosephE. 1080-143 treatment strategiesfromanevidence basedviewpoint Objective: Assessclinicaloutcomesafteratrialfibrillation Learning UMDNJ-RWJ MedicalSchool, New Brunswick, NJ Saksena, Electrophysiology ResearchFoundation, Warren, NJ, April Slee, SnehalRathod, AnkushVerma, TinaLiu, Sanjeev 1081-148 outcomes inpatientswithatrialfibrillationandthyroid disease Objective:Evaluatetheimpactoftreatment strategieson Learning RWJ MedicalSchool, New Brunswick, NJ Rathod, Electrophysiology ResearchFoundation, Warren, NJ, UMDNJ- Sanjeev Saksena, April Slee, TinaLiu, AnkushVerma, Snehal 1081-147 atrial fibrillation as a“pillinthepocket” agentforthetreatmentofepisodes Objective:Describeourexperienceusingoralranolazine Learning Wausau, WI, CaREFoundation, Inc., Wausau, WI Wisconsin,Larrain, CardiovascularS.C., Associates ofNorthern David K.Murdock, JamesA.Reiffel, Jeffrey W. Kaliebe, German Disease “Pill inthePocket” Heart ApproachinStructural withOralRanolazine: ImplicationsforFibrillation The Conversion ofParoxysmal orInitialOnset Atrial 1 CME/CE Hours: 3:30p.m.-4:30 Presentation Hour: Georgia World CongressCenter, HallB5 Sunday, March14, 2010, 1:30p.m.-4:30 SUPRAVENTRICULAR ARRHYTHMIAS Veins IsolationofPulmonary Antral Cryo Long Term EfficacyandImpactofBalloonSizein Ablation? Fibrillation Should Anti-arrhythmics BeHeldPriortoAtrial in theAFFIRMtrial Composite andIndividualCardiovascular Outcomes Impact ofIndividualTreatment Strategieson Disease PatientsOutcomes ofAtrialFibrillation withThyroid Impact ofTreatment StrategiesonClinical JACC March 9, 2010 Cardiac Arrhythmias A7 ABSTRACTS: Cardiac Arrhythmias Cardiac ABSTRACTS: Focal Atrial and Ventricular Tachycardias from the Tachycardias Atrial and Ventricular Focal Mitral Annulus: Common Mechanism? Novel Isthmus Ablation by Cavo-tricuspid Photodynamic Laser Catheter in Swine Heart in vivo Change in Does Parasympathetic-mediated Restitution and Alternans Characteristics Contribute Atrial Fibrillation? to Vagal Risk Factors for RecurrentSyncope in Long QT for Risk Factors Syndrome Breathing be an Independent Can Sleep-Disordered in Arrhythmias Ventricular Predictor of Malignant Heart with Patients Failure? of Electrocardiographic High Frequency Abnormalities at Early in Repolarization Phase Fibrillation Idiopathic Ventricular David Gordon, Rishi Arora, Roger Villuendas, Brandon Benefield, Brandon Benefield, Roger Villuendas, Rishi Arora, Gordon, David J. Goldberger, Jeffrey Shade, Greg Greene, Rodney Harris, Kathy IL Chicago, Northwestern Jason Ng, University, Alan H. Kadish, Learning Objective: describe the important contributors to vagally mediated atrial fibrillation. 1133-125 M. Markowitz, Steven J. Broderick, Ryan H. Chung, Jeffrey Sei Iwai, Brook University Medical Stony Bruce B. Lerman, Liu, Christopher F. New Cornell University Medical Center, NY, Brook, Stony Center, York, NY Learning characteristics of focal Objective: describe the clinical mitral annular atrial and ventricular tachycardias 1133-126 Hajime Mizuki Ide, Kajihara, Takuro Arisa Itoh, Shunichiro Miyoshi, Kotaro Tanimoto, Kojiro Kimura, Takehiro Mei Takahashi, Suenari, Satoshi Futami, Yasuhiko Satoh, Toshiaki Seiji Takatsuki, Fukumoto, Tokyo, University School of Medicine, Keio Tsunenori Arai, Ogawa, Tokyo, University School of Science and Technology, Keio Japan, Japan learn photodynamic laser feasibility of novel Learning Objective: To catheter ablation in vivo. 1133-127 1133-121 Ming Qi, Ilan Goldenberg, McNitt, Scott Jons, Christian Liu, Judy F. University Arthur of J. Moss, Jennifer L. Robinson, Zareba, Wojciech NY Rochester, Center, Rochester Medical Learning Identify the predictors Objective: for recurrent syncope in Long QT Syndrome 1133-123 Yagishita, Yoshimi Daigo Yagishita, Dai Yumino, Naoki Serizawa, Morio Shoda, Atsushi Takagi, Manaka, Tetsuyuki Ejima, Koichiro Japan Tokyo, Medical University, Women’s Tokyo Nobuhisa Hagiwara, Learningrisk of identify sleep-disordered breathing as a Objective: with heart in patients arrhythmia life-threatening ventricular failure 1133-124 Masahito Sato, Kazuki Okamura, Hiroshi Watanabe, Hayashi, Yuka Hirotaka Oda, Masaomi Chinushi, Hiroshi Furushima, Hosaka, Yukio Niigata Division of Cardiology, Aizawa, Yoshifusa Masaaki Okabe, Niigata Idiopathic Japan, Niigata, University School of Medicine, Japan Niigata, Fibrillation Study Group, Ventricular Learning ECG characteristics assocaited with Objective: evaluate idiopathic ventricular fibrillation. Risk Factors of Self-Terminating and Perpetuating and Perpetuating of Self-Terminating Risk Factors in Post-Infarction Tachyarrhythmias Ventricular with Moderately Depressed Left Ventricular Patients a CARISMA Sub-Analysis Function, ARRHYTHMIAS: RISK STRATIFICATION 9:30 a.m. - 12:30 p.m. 2010, March 15, Monday, Hall B5 Congress Center, Georgia World Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Prevention of RecurrentPrevention Atrial Fibrillation with Angiotensin-Converting Enzyme Inhibitors or A Meta-analysis of Angiotensin Receptor Blockers: Randomized Trials N-3 Poly-Unsaturated Fatty Acids for the Acids for Fatty N-3 Poly-Unsaturated of Atrial FibrillationPrevention Recurrence After Electrical Cardioversion of Chronic Persistent Double-Blind, Atrial Fibrillation. A Randomized, Multicentre Study. Serum Acid as a Predictor of Incident Uric Atrial Fibrillation: Risk in The Atherosclerosis Communities Study Elevated BNP Predicts New Onset Atrial Fibrillation Onset Atrial New BNP Predicts Elevated Infarction: Analysis Acute Myocardial Complicating Registry of the Triumph Juha Perkiomaki, Poul-Erik Bloch Thomsen, Marc Messier, Heikki Marc Messier, Bloch Thomsen, Poul-Erik Juha Perkiomaki, Dept. of Internal the CARISMA Study Investigators, Huikuri, Finland Oulu, University of Oulu, Medicine, Learning Objective: identify differences in electrophysiological self-terminatingsubstrate and modifiers between of arrhythmias and perpetuating ventricular tachyarrhythmias 1133-120 CLINICAL ELECTROPHYSIOLOGY--VENTRICULAR ELECTROPHYSIOLOGY--VENTRICULAR 1133 CLINICAL Rohit Bhuriya, Updesh Bedi, Amol Bahekar, Janos Molnar, Mukesh Mukesh Janos Molnar, Amol Bahekar, Updesh Bedi, Rohit Bhuriya, Rohit Sandeep Khosla, Singh, Puneet Param Patel, Pawan Singh, North IL Chicago Medical School, Chicago, The Arora, Learning angiotensin blockade in the Objective: Identify the role of of recurrentprevention atrial fibrillation 1081-153 Leopoldo Bianconi, Leonardo Calò, Silvia Mennuni, Luca Santini, Luca Santini, Silvia Mennuni, Leonardo Calò, Leopoldo Bianconi, Francesco Giuseppe Barbato, Azzolini, Paolo Morosetti, Paolo Italy Rome, Massimo Santini, Romano, Paolo Biscione, Learning fatty acids Objective: know that n-3 poly-unsaturated of atrial fibrillation recurreceare not useful for prevention after electrical cardioversion of chronic persistent atrial fibrillation 1081-152 Leonardo Tamariz, Sunil Agarwal, Elsayed Soliman, Alanna Soliman, Elsayed Sunil Agarwal, Leonardo Tamariz, Ambrose, Marietta Aaron Folsom, Ronald Prineas, Chamberlain, FL Miami, University of Miami, Alvaro Alonso, uric acid and Learning Describe the relationship between Objective: atrial fibrillation 1081-150 Susmita Parashar, Jonathan J. Langberg, Viola Vaccarino, Kimberly Viola Vaccarino, J. Langberg, Jonathan Susmita Parashar, Atlanta, Emory University, Michael S. Lloyd, John Spertus, J. Reid, MO Kansas City, Mid America Heart Institute, GA, Learning interpret Objective: the role of biomarkers in predicting infarction. atrial fibrillation after acute myocardial new 1081-149 JACC March 9, 2010 2010 9, March JACC Cardiac Arrhythmias Atrial Fibrillation after Coronary Artery BypassGrafting Artery after Coronary Atrial Fibrillation ofNew Onset Objective: Identifymodifiableriskfactors Learning Marc Gillinov, EugeneH.Blackstone, Cleveland Clinic, Cleveland, OH Roop K.Kaw, AdrianV. Hernandez, IqbalMasood, Walid Saliba, A. 1134-133 operatively inminimallyinvasive surgicalMAZE. ofEPtestingintra- Objective:Evaluatetheimportance Learning Center, Phoenix, AZ, Veterans AffairMedicalCenter, Phoenix, AZ Desser, Kenneth Fang, WilberSu, BannerGoodSamaritanMedical Yosef Kahn, Kathleen Benson, Francisco Gonzalez, Kenneth B. 1134-132 syndrome atriskofsuddendeath Objective:IdentifysymptomaticpatientswithWPW Learning Pappone,Carlo SanRaffaeleUniversity-Hospital, Milan, Italy Stefania Sacchi, Massimo Saviano, AmarildCuko, Valerio Giordano, Vicedomini, Pasquale Vergara, GabrielePaglino, CristianoCiaccio, Santinelli,Vincenzo AndreaRadinovic, GiuseppeCiconte, Gabriele 1134-131 EP lab Objective:DistinguishthemainmechanismofPSVTin Learning Madrid, Fernández-Avilés, GregorioMarañón, HospitalGeneralUniversitario Leonardo Atea,Pachón, Marta David Calvo, AngelMiracle, Francisco Fernández, MiguelAngelArias, Felipe Atienza, Tomás Datino, Esteban Gonzalez-Torrecilla, AngelArenal, Francisco Javier García- 1134-130 fortreatmentofAVNRTcryoablation inchildren. Objective:Recognizethesafetyandefficacyof Learning Center,Heart Atlanta, GA Strieper, Peter Fischbach, Children’s HealthcareofAtlanta, Sibley J Bradley, SusanEtheridge, ElizabethSaarel, Patrick Frias, Margaret Srikant Das, IanLaw, NicholasVon Bergen, MacDonaldDick, David 1134-129 1134 CLINICAL ELECTROPHYSIOLOGY-- A8 Sytematic Review andMeta-Analysis BypassGraft:A Artery afterCoronary Fibrillation inNew andLongTerm OnsetAtrial Mortality Short Without Intra-operativeElectrophysiology Testing Minimally Invasive SurgicalMAZEisInadequate Presenting withMalignantArrhythmias Up Studyof201SymptomaticWPWPatients Parkinson-White Syndrome.AProspectiveFollow- ofSuddenDeathinPatientsPredictors withWolff- Long Ventriculoatrial Intervals Distinguishing Supraventricular Tachycardias With Entrainment andTachycardia: ASimplerMethodin Difference inVentriculoatrial During Intervals Experience for AVNRTCryoablation inChildren-aMulti-Center Ratesafter High SuccessandLowRecurrence 1 CME/CE Hours: 9:30a.m.-10:30 Presentation Hour: Georgia World CongressCenter, HallB5 Monday, March15, 2010, 9:30a.m.-12:30p.m. SUPRAVENTRICULAR ARRHYTHMIAS ABSTRACTS: Cardiac Arrhythmias 1135-137 1135 CLINICAL ELECTROPHYSIOLOGY-- supraventricular arrhythmia andatrialremodeling Objective:ToLearning demonstrate therelationshipbetween miyazaki, miyazaki, Japan of medicine,facultyofmedicine,university ofinternal department Ishikawa, Toshiro Nagoshi, HaruhikoDate, KazuoKitamura, first Tsuruda, HisamitsuOnitsuka, RiichiroKawamoto, Tetsunori Erika Nagatomo, Yunosuke Matsuura, Takeshi Ideguchi, Toshihiro Junji Kawagoe, Takuroh Imamura, Keishi Kubo, Sakamoto, Sumiharu 1134-136 fibrillation afterlungtransplantation Objective:ToLearning ofatrial describe the naturalhistory Minnesota, Minneapolis, MN Adkisson, Lyn Chen, Hertz,David Marshall G.Benditt, Univerityof Santiago Garcia, MarianaCanoniero, SrinivasanSattiraju, Wayne 1134-135 Learning Objective: evaluate strokeLearning riskstratification Di Angelantonio, ArielCohen, HopitalSaintAntoine, Paris, Berthelot, Fanny Douna, NadiaAissaoui, Franck Boccara, Emmanuel Dufaitre, CatherineMeuleman, NabilaHaddour, Emmanuelle stephane ederhy, LouiseBoyer-Chatenet, SylvieLAng, Ghislaine 1135-140 fibrillation of dofetilideinmaintainingsinusrhythm inpatientswithatrial Objective:ToLearning ofeffectiveness identifythepredictors School ofMedicine, University Atlanta,Emory GA Langberg, Richard N.Vest, III, HeatherL.Bloom, MichaelS.Lloyd, Venkata V. Bavikati, J.Ryan Jordan, Pankaj Manocha, JonathanJ. 1135-138 ofthromboembolism Objective:describethemarkers Learning decardiologie,service Paris, France AISSAOUI, Franck BOCCARA, ArielCOHEN, hopitalsaintAntoine Nabila HADDOUR, Emmanuelle BERTHELOT, Fanny DOUNA, Nadia DUFAITRE, EmanueleDiANGELANTONIO, CatherineMEULEMAN, Sylvie LANG, StephaneEDERHY, LouiseBOYER-CHATENET, Ghislaine CHADS 1 CME/CE Hours: 9:30a.m.-10:30 Presentation Hour: Georgia World CongressCenter, HallB5 Monday, March15, 2010, 9:30a.m.-12:30p.m. SUPRAVENTRICULAR ARRHYTHMIAS Supraventricular Tachycardia Significance ofCardiac Troponin Tlevels in Incidence, andLong-Term Predictors Implications AfterLungTransplantation:Atrial Fibrillation And AChads Do AllPatients WithNonValvular AtrialFibrillation Fibrillation the Antiarrhythmic EfficacyofDofetilide onAtrial DiseasePotentiates Artery Coronary Underlying Eastern-paris Cohort-study Of Atrial Fibrillation ? OfAtrialFibrillation Cohort-study Eastern-paris The SameRiskOfCardiovascular Events:The Fibrillation: a single-center cohort study asingle-center cohort Fibrillation: FailureStroke inPatients andHeart withAtrial 2 score Predicts the Occurrence ofDeath, scorePredictstheOccurrence 2 ScoringSystem=1Patients Have JACC March 9, 2010 Cardiac Arrhythmias A9 ABSTRACTS: Cardiac Arrhythmias Cardiac ABSTRACTS: Intravenous CorticosteroidIntravenous Use Is Associated with Reduced Early Recurrence of Atrial Fibrillation Radiofrequency Catheter Ablation Following Catheter Ablation of Atrial Fibrillation Is Associated And with Significant Reduction in Left Atrial Dimensions Pulmonary Vein and Clinical Significance of Carina- The Prevalence LA Conduction after Successful Pulmonary Vein Atrial FibrillationIsolation for General Anesthesia Reduces the Prevalence of Prevalence Reduces the General Anesthesia Repeat Reconnection during Pulmonary Vein Sedation: Compared to Conscious Ablation when a Randomized Study Results from Ablation of for Remote Magnetic Navigation Atrial Fibrillation Irrigation with the Open Ablation Catheter: Acute Endpoint with Circumferential Ablation versus Guided Ablation Circular Mapping 1136-150 Kluger, Jeffrey Craig I. Coleman, Nitesh A. Sood, GuruM. Krishnan, University of Connecticut, Christopher A. Clyne, Moise Anglade, Hartford Hartford, CT Hospital, Hartford, CT, corticosteroidLearning of intravenous Objective: Describe the effect use on early recurrence of atrial fibrillation (ERAF) following for AF. successful radiofrequency catheter ablation 1136-152 Robert E. El-Chami, Mikhael F. Robert L. Eisner, Shahriar Iravanian, GA Atlanta, Emory University, Jr., O’Donnell, describe the anatomical we Learning Objective: In this study, changes in the heart after catheter ablation of atrial fibrillation as cardiac MRI. measured by 1136-153 Kiyotake Yamamoto, Takashi Yoshida, Yukihiko Masateru, Takigawa Mamoru Nanasato, Tatematsu, Yasushi Natsuo Inoue, Ishikawa, Cross Society Nagoya Japanese Red Haruo Hirayama, Tsuboi, Naoya Japan Nagoya, Daini Hospital, Learning Objective: know the clinical significance of carina-left atrial conduction after successful pulmonary vein isolation 1136-148 Sanchez, Javier Mohanty, Prasant Burkhardt, J. David Luigi Di Biase, Vladimir Santangeli, Pasquale Bailey, Horton, Shane Rodney Jacquie Kim, Karla Wolker, Conor Barrett, Claude S. Elayi, Astudillo, Richard Hongo, Hao, Steven Mitra Mohanty, Dimpi Patel, Kai Zedlitz, TX Austin, Medical Center, St. David’s Andrea Natale, Beheiry, Salwa Learning of general aneshtesia during if the use evalute Objective: fibrillation is associated with a lower catneter ablation of atrial pulmonary sedation reconnection when compared to conscious vein 1136-149 Lakkireddy, Dhanunjay Burkhardt, J. David Luigi Di Biase, Horton, G. Joseph Rodney Pillarisetti, Jayasree Sanchez, Javier Mitra Mohanty, Prasant Mohanty, Shane Bailey, Gallinghouse, Santangeli, Pasquale Beheiry, Salwa Hao, Steven Richard Hongo, Conor Barrett, Claude S. Elayi, Dimpi Patel, Vladimir Astudillo, TX Austin, Medical Center, St. David’s Andrea Natale, Learning Objective: determineif magnetic robotic navigation with open irrigated or not without achieving catheter is effective electrical isolation of the pulmonary vein The Strategy of Catheter Ablation for Persistent/ The Strategy of Catheter Ablation for permanent Atrial Fibrillation with in the Patients Immediate Recurrence after Cardioversion SUPRAVENTRICULAR ARRHYTHMIAS SUPRAVENTRICULAR 9:30 a.m. - 12:30 p.m. 2010, March 15, Monday, Hall B5 Congress Center, Georgia World Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Better Lesions in the to Achieve Technique A Novel Coronary And Feasibility Safety Sinus: Genetic, but Not Conventional Risk Factors Predict Factors Risk but Not Conventional Genetic, Ischemic Attack in Lone or Transient Risk of Stroke Atrial Fibrillation The Ventricular Rate at Onset of Atrial Fibrillation The Ventricular Predicts Heart Hospitalization and Mortality Failure in Cardiac Resynchronization Patients Melphalan Induced Atrial Arrhythmias: Incidence Arrhythmias: Melphalan Induced Atrial and Risk Factors Left Atrial Expansion Index in Patients with with Expansion Index in Patients Left Atrial Atrial Fibrillation Rhythm a Predictor of Sinus Is after Cardioversion Maintenance Koichi Inoue, Toshiya Kurotobi, Ryusuke Kimura, Yuko Toyoshima, Toyoshima, Yuko Kimura, Ryusuke Kurotobi, Toshiya Inoue, Koichi Sakurabashi- Center, Cardiovascular Katsuomi Iwakura, Norihisa Ito, Japan Osaka, Hospital, Watanabe Learning Objective: identify the patients who do not need intensive left atrial modification at the ablation procedure for persistent atrial fibrillation 1136-147 Luigi Di Biase, Daniel T. Wallace, Aaron P. Grogan, Dale J. Bergman, Dale J. Bergman, Grogan, Aaron P. Wallace, Daniel T. Luigi Di Biase, Cardiac Texas Andrea Natale, Prasant Mohanty, R. Raju, Narayan TX Austin, Institute, Arrhythmia to isolate the Learning Objective: identify a possible alterative way coronary sinus during radiofrequency ablation 1136-146 CLINICAL ELECTROPHYSIOLOGY-- 1136 CLINICAL Edwin T. Zishiri, Peter Hanna, Michael Tchou, Diana Bauer, Robert C. Diana Bauer, Michael Tchou, Hanna, Peter Zishiri, T. Edwin Mina K. Wagoner, Van David Jonathan Smith, John Barnard, Wirka, OH Cleveland, Clinic, Cleveland Chung, Learning genetic epidemiology Objective: Indentify the need for research to understand or TIA in lone atrial fibrillation the risk predictors of stroke 1135-144 Bruce A. Koplan, Stan Weiner, Milan Seth, Paul W. Jones, Shelly A. Jones, W. Paul Milan Seth, Stan Weiner, Bruce A. Koplan, MA Boston, Hospital, Brigham and Women’s Christman, an Learning with AF who have Objective: identify CRT patients increased morbidity and mortality 1135-143 Victor Feliz, Saleem Saiyad, Sumana M. Ramarao, Hammad Khan, Khan, Hammad Sumana M. Ramarao, Saleem Saiyad, Victor Feliz, H. Lee Moffitt FL, Tampa, University of South Florida, Guglin, Maya FL Tampa, Institute, Cancer Center and Research determine which chemotherapeutic agent is Learning To Objective: closer monitoring. and therefore needs more arrhythmogenic 1135-142 Malini Govindan, Anatoli Kiotsekoglou, Velislav Batchvarov, Samir Samir Batchvarov, Velislav Anatoli Kiotsekoglou, Malini Govindan, St John Camm, Brodin, Lars-Ake Teoh, Evaun Kate Dougal, K. Saha, United Kingdom London, Georges University of London, Learning AF Predictive value of LA expansion index in Objective: 1135-141 JACC March 9, 2010 2010 9, March JACC Cardiac Arrhythmias nonischemic patientsenrolledinMADIT-CRT response topreventive CRT-D therapy between ischemicand and Objective:Identifydifferencesinclinical course Learning Center, Durham, NC Center, Rochester, NY, Division, Cardiology Duke Medical University P. Division, Daubert,Cardiology ofRochesterMedical University E.Goldstein,Robert ClaudioSchuger, Wojciech Zareba, James David T. Huang, ScottMcNitt,W. Mary Brown, Jeffrey J.Goldberger, Alon Barsheshet, J.Moss, IlanGoldenberg, Arthur MichaelEldar, 1188-124 defibrillatorrecipients fibrillation inimplantablecardioverter ofatrial Objective:demonstratetheprognosticimportance Learning Schalij, MedicalCenter, LeidenUniversity Leiden, TheNetherlands Enno T. vanderVelde, LieselotvanErven,JeroenJ.Bax, J. Martin Johannes B.Van Rees, C.JanWillemBorleffs, GuidoH.Welsenes, 1188-123 therapy function andthebenefitofpreventive cardiacresynchronization Objective:ToLearning evaluate therelationshipbetween renal Brigham andWomen’s Hospital, Boston, MA Investigators, ofRochesterMedicalCenter, University Rochester, NY, W.Mary Brown, Wojciech Zareba, MarcA.Pfeffer, theMADIT-CRT J.Moss,Ilan Goldenberg, Arthur ScottMcNitt, AlonBarsheshet, 1188-121 failurewhohave anICDandundergoexercisetraining. heart Objective:Describearrhythmic outcomesinpatientswith Learning Durham, NC, Medical College, Jefferson Philadelphia, PA L. Piña, ChristopherM.O’Connor, Duke ClinicalResearchInstitute, Ellis, Steven J.Keteyian, Lawton Cooper, WilliamE.Kraus, Ileana Jonathan P. Piccini, AnneS.Hellkamp, David J.Whellan, StephanJ. 1188-120 1188 DEFIBRILLATION/IMPLANTABLE A10 the MADIT-CRT Study Ischemic andNonischemicCardiomyopathy from Resynchronization Therapy inPatients with Risk Factors for ResponsetoCardiac Patients Defibrillator inImplantableCardioverter Survival Appropriate andInappropriateDevice Therapy and The RoleofDifferent Types on ofAtrialFibrillation MADIT-CRT Preventive Cardiac ResynchronizationTherapy in Relation between RenalFunction andResponseto Results fromHF-ACTION Defibrillator Shocksin Failure: Patients withHeart Exercise Training andImplantableCardioverter 1 CME/CE Hours: 3:30p.m.-4:30 Presentation Hour: Georgia World CongressCenter, HallB5 Monday, March15, 2010, 1:30p.m.-4:30 ANTIARRHYTHMIA DEVICES ABSTRACTS: Cardiac Arrhythmias 1188-127 defibrillator the wearable cardioverter Objective:ToLearning evaluate thecomplianceandeffectivenessof Cleveland, OH Niebauer, D. Bruce Lindsay, Patrick J.Tchou, Cleveland Clinic, Mina K.Chung, Steven J.Szymkiewicz, Shao, Mingyuan J. Mark 1188-126 following ICDtreatment andtheeffectofdevice replacement surgical re-interventions Objective:describetherequirementofpocketLearning related MedicalCenter,Leiden University Leiden, TheNetherlands van Erven,JeroenJ.Bax, SuzanneC.Cannegieter, J.Schalij, Martin B. vanRees, GuidoH.vanWelsenes, E.vanderWall, Ernst Lieselot Joep Thijssen, C.JanWillemBorleffs, MihályK.deBie, Johannes 1188-125 patients withventricularassistdevices. theincidenceofICDtherapies in Objective: determine Learning Medical Center, Rochester, NY Massey, Leway Chen, David T. Huang, ofRochester University Mehmet Aktas, SushmaKoneru, AbrarShah, SamitShah, Todd 1189-130 Testing. Objective:describethefutilityofDefibrillation Threshold Learning Jacob, Wayne StateUniversity, Detroit, MI Aditya S.Bharadwaj, Rajeev Aravindhakshan, LuisC.Afonso, Sony 1189-129 1189 after electiveICDimplantation ofcomplications thepredictors Objective:Understand Learning Hospitals, Royal Oak, MI David E.Haines, JepthaP. Curtis, Yongfei Wang, Beaumont Data from the National ICD Registry (ICDR®) Data fromtheNationalICDRegistry for Elective ICDImplantation: Procedure Mortality Failure (B2C3Score)Predicts andCardiacArrest Blood Pressure, BUN, Creatinine, CongestiveHeart Compliance andSurvival Cardioverter-Defibrillator Vest: EventRates, Aggregate NationalExperiencewiththeWearable Non-Infectious Causes. duetoInfectiousfor and SurgicalRe-intervention The Effect ofICDReplacementontheRequirement Patients withVentricular AssistDevices TherapiesinAmbulatory Cardioverter-Defibrillator ofImplantable Incidence andPredictors Meta Analysis orPredictClinicalOutcomes:A Overall Survival Defibrillation Threshold Testing DoesnotImprove 1 CME/CE Hours: 3:30p.m.-4:30 Presentation Hour: Georgia World CongressCenter, HallB5 Monday, March15, 2010, 1:30p.m.-4:30 ANTIARRHYTHMIA DEVICES DEFIBRILLATION/IMPLANTABLE JACC March 9, 2010 Cardiac Arrhythmias ABSTRACTS: Cardiac Arrhythmias Cardiac ABSTRACTS: A11 Local Voltage Potentials Are Prerequisites for Are Prerequisites for Potentials Local Voltage Tract Ectopy Outflow Externally-Irrigated Radiofrequency Ablation is Safer than Non-Irrigated Ablation and more Effective in the Aortic a by Region-Insights Provided Cusp Retrograde ICE-Guided Approach Regional Scar Encircling Limited Linear Ablation for Tachycardia Ventricular Post-infarction to Treat Using a Standardized Mapping and Ablation Approach TACHYCARDIA: NEW INSIGHTS TACHYCARDIA: - 4:30 p.m. 1:30 p.m. 2010, March 15, Monday, Hall B5 Center, Congress Georgia World Hour:Presentation 4:30 p.m. 3:30 p.m. - CME/CE Hours: 1 Arrhythmias of Ventricular Mapping and Ablation Papillary Muscles Ventricular Originating from Right Combined Endocardial And Epicardial Infarct Porcine Electroanatomic Mapping Of A Novel And CartoModel: A Comparison Of Navx Thomas Deneke, Thomas Lawo, Dong-In Shin, Marc Horlitz, Andreas Marc Horlitz, Shin, Dong-In Thomas Lawo, Thomas Deneke, Academic Heart Center Cologne, Bernd Lemke, Leif Bösche, Mügge, Germany Cologne, Learning Objective: Easy and effective ablation of post-ischemic ventricular tachycardia 1190-140 Jorgen Christian Jons, Arne Johannessen, Erik Bloch Thomsen, Poul Sogaard, Peter Charles Knud Saermark, Antzelevitch, K. Kanters, Copenhagen, Gentofte University Hospital, Cardiology Department P, NY Utica, Masonic Medical Research Laboratory, Denmark, Learning Objective: Identify and understand the mechanisms of for right ventricular local potentials at successful ablation sites outflow tract ectopy 1190-141 University of Brion Winston, Samir Saba, R. Bazaz, Raveen PA Pittsburgh, Pittsburgh Medical Center, Learning Objective: Understand ablation technology to use for aortic cusp ablation 1190-142 1190 OF VENTRICULAR ABLATION MAPPING AND 1190-137 Karl J. IIg, Timir S. Baman, Crawford, Thomas Miki Yokokawa, Krit Jongnarangsin, Aman Chugh, Eric Good, K. Gupta, Sanjaya Division Bogun, Frank Morady, Fred Hakan Oral, Jr, Pelosi, Frank University of Center, Cardiovascular Medicine, of Cardiovascular MI Ann Arbor, Michigan, Learning arising from identify the ventricular arrhythmias Objective: the right ventricular papillary muscle 1190-138 Daniel Chi Lai, Rafael Ramirez, Shiro Nakahara, Roderick Tung, UCLA Shivkumar, Kalyanam Finn, Paul Fishbein, Michael Ennis, CA Los Angeles, Medical Center, Learning of electroanatomic Objective: Evaluate the accuracy mapping systems for ventricular scar mapping. Respiratory in Addition Hepatic Impairment, and Prior to ICD Up to One Week to Renal Dysfunction, Implantation Predicts Increased Mortality Experience With Fidelis Lead Extractions at a Single Academic Center Factor Disease is a Significant Risk Chronic Kidney after Pacemaker Hematoma Formation of Pocket and Implantable Cardioverter- Defibrillator and Placement Independent of Anticoagulation Antiplatelet Agents Implantable Cardiac Rhythm Devices are Devices Rhythm Implantable Cardiac Risk of SternalAssociated with an Increased after Cardiac Surgery Infection Wound Inappropriate Implantable CardioverterInappropriate Defibrillator MortalityShocks Increase Daniel Chong, Kah Leng Ho, Reginald Liew, Wee Siong Teo, Chi Siong Teo, Wee Reginald Liew, Kah Leng Ho, Daniel Chong, Singapore National Heart Singapore, Ching, Keong Centre, Learning Objective: Identify predictors of mortality pre-ICD implantation 1189-136 Imdad Ahmed, William B. Nelson, Chad M. House, Ranjan Dahiya, Ranjan Dahiya, Chad M. House, William B. Nelson, Imdad Ahmed, St.Paul, Regions Hospital,University of Minnesota, Zhu, Dennis W.X. MN Learning hematoma Objective: Identify the risk factors of pocket and ICD placement formation in patients with pacemaker 1189-135 Jayasree Pillarisetti, Jillian Falbe, Raghuveer Dendi, Rhea Pimentel, Rhea Pimentel, Raghuveer Dendi, Jillian Falbe, Pillarisetti, Jayasree University Loren Berenbom, Martin Lakkireddy, Emert, Dhanunjaya KS Kansas City, of Kansas Hospital, Learning of a single academic Objective: describe the experience center with extraction of Fidelis leads 1189-133 Alireza Nazeri, James M. Wilson, Abdi Rasekh, Mohammad Saeed, Saeed, Mohammad Abdi Rasekh, James M. Wilson, Alireza Nazeri, Ali Massumi, MacArthur Lee, Elayda, Vei-Vei Christopher Frank, Episcopal Hospital, Heart Institute at St. Luke’s Texas Mehdi Razavi, TX Houston, TX, Houston, implanted Learning Describe the relationship between Objective: (ICRDs) and sternal devices wound infection (SWI) cardiac rhythm after coronary artery grafting (CABG). bypass 1189-132 Johannes B. Van Rees, C. Jan Willem Borleffs, Mihály K. de Bie, Mihály K. de Bie, Willem Borleffs, C. Jan Rees, Van Johannes B. Martin Bax, J. Schalij, van Erven, Jeroen J. Lieselot Theo Stijnen, The Leiden, Leiden UniversityCenter, Medical Learning are demonstrate that inappropriate ICD shocks Objective: mortalityassociated with increased in the ‘real’ world 1189-131 JACC March 9, 2010 2010 9, March JACC Cardiac Arrhythmias Cardiology, SchoolofMedicine, IndianaUniversity Indianapolis, IN C. Lopshire, JohnM.Miller, WilliamJ.Groh,Instituteof Krannert Miriam R.Groh, DeepakBhakta, AnilYadav, MithileshK.Das, John Sameh , Kairav P. Vakil, AhmadM.Alqaqa’a, HelenL.Flippin, 1191-148 outcomes atfollow-upof>6months patients withICDsorPPMsundergoingMRIsafeclinical Objective:identifyasubsetofpacemaker-non-dependentLearning LLC, Indianapolis, IN Fogel, EricN.Prystowsky, Hospital;TheCareGroup, SaintVincent Roshan Vatthyam, Matthew Cantrell, MichaelD. Elliott, RichardI. 1191-147 practice inrelationtoICDtherapy aboutwhatphysicians Objective:Learn sayLearning they dointheir Denver, CO Clinical ResearchInstitute, Durham, NC, ofColorado, University O’Brien, LouiseZimmer, Fred A.Masoudi, EricD. Peterson, Duke Sana M.Al-Khatib, GillianD. Sanders, DanielD. Matlock, Sean 1191-146 1191 DEFIBRILLATION/IMPLANTABLE guided radiofrequencyablationofatrialfibrillation. complex fractionatedatrialelectrograms(CFAE)s inelectrogram- thepotentiallimitationofusing Objective:Understand Learning Chicago, IL Kadish, University, Northwestern Feinberg SchoolofMedicine, Aleksey Borodyanskiy, JasonNg, Jeffrey J.Goldberger, AlanH. 1190-144 patients withischaemiccardiomyopathy echocardiography toguideablationofventriuclartachycardia in Objective:Evaluatethevalueofrealtimeintracardiac Learning Fred Morady, Frank Bogun, ofMichigan, University AnnArbor, MI Chin Pang Chan, HakanOral, Frank Pelosi, EricGood, AmanChugh, 1190-143 A12 in DefibrillatorImplantation Propofol Use:ASafe andEffective SedationOption Nursing-Administered, Proceduralist-Directed Imaging at1.5-Tesla Pacemakers UndergoingMagneticResonance and Permanent Cardioverter-Defibrillators Safety OutcomesinPatients withImplantable Minorities, andOlderPatients? Defibrillatorto Cardioverter Women, Racial Are Physicians LessLikely toOffer anImplantable 1 CME/CE Hours: 3:30p.m.-4:30 Presentation Hour: Georgia World CongressCenter, HallB5 Monday, March15, 2010, 1:30p.m.-4:30 ANTIARRHYTHMIA DEVICES in Perpetuating AtrialFibrillation? AreAllCFAEsModel ofAtrialFibrillation: Significant Complex Fractionated AtrialElectrogramsinaFocal Infarction Ventricular Tachycardia Electroanatomic MappinginPatients withPost IntracardiacEchocardiographyReal Time and ABSTRACTS: Cardiac Arrhythmias 1191-153 of lifecareICDs Objective:describetheopinionsofpatientsregardingend Learning ofPennsylvania,University Philadelphia, PA James N.Kirkpatrick, Priya Sehgal, Rutuke Patel, RalphJ.Verdino, 1191-150 revascularization. after coronary andappropriateshocktherapy demonstrate benefitinmortality who defibrillators populations withimplantablecardioverter Objective:IdentifyischemiccardiomyopathyLearning patient Hospital,Hartford Hartford,CT Guertin, Ravi Yarlagadda, ChristopherA.Clyne,Kluger, Jeffery B.Huddy,Karlyn Sanjeev P. Bhavnani, CraigI.Coleman, Danette 1191-149 of LVH Objective: recognizethevalueof3-DECGindiagnosis Learning Sciences CenteratSanAntonio, SanAntonio, TX J.Carothers, TerryCurtis D. Bauch, ofTexas University Health 1243-124 greatest utilityfordetectingleftatrialenlargementby CT. whichECGparameterwillhave Objective:determine the Learning Udo Hoffmann, MassachusettsGeneralHospital, Boston, MA Fabian Bamberg, RonBlankstein, ThomasJ.Brady, JohnT. Nagurney, Joao D. Fontes, MatthiasKriegel, ThomasIrlbeck, AmirA.Mahabadi, Quynh A.Truong, ElizabethM.Charipar, LeonPtaszek, Carolyn Taylor, 1243-123 1243 needed andlargerstudiesarerequiredtojustifyitsroutinepractice. resynchronization therapy-defibrillator recipientsisprobablynot Objective:Recognizethatdefibrillationtestingincardiac Learning East Lansing, MI School ofMedicine, LosAngeles, CA, MichiganStateUniversity, Shivkumar, at LosAngeles/David ofCalifornia Geffen University Tahmeed A.Contractor, Yoav Michowitz, Tara Bourke, Kalyanam Defibrillator Implantation? Patients WithCardiacResynchronizationTherapy- Should DefibrillationThresholdBe Tested in on EndofLife HandlingofICDs Living Willsfor Defibrillators: Patient Perspectives Outcomes? Defibrillator andIschemicCardiomyopathy Improve in Patients withanImplantableCardioverter Revascularization Does Previous Coronary in IdentifyingLeftVentricular Hypertrophy The RoleofThree-DimensionalElectrocardiography Trial Left AtrialVolume Enlargement:From theROMICAT Compared toComputedTomography Measuresof Usefulness ofElectrocardiographicParameters as 1 CME/CE Hours: 9:30a.m.-10:30 Presentation Hour: Georgia World CongressCenter, HallB5 Tuesday, March 16, 2010, 9:30a.m.-12:30p.m. CORRELATES ECG -ANATOMIC ANDPHYSIOLOGIC JACC March 9, 2010 Cardiac Arrhythmias ABSTRACTS: Cardiac Arrhythmias Cardiac ABSTRACTS: A13 J-Point Elevation Prior to Acute Myocardial Prior to Acute Myocardial Elevation J-Point Ventricular Infarction Does Not Increase Risk for Arrhythmias of n-3 Polyunsaturated Atrial Protective Effects Study in Ovine Chronic Acids: A Long Term Fatty Heart Failure Clinical Predictors of Early Mortality among Patients Cardioverterwith Implantable Defibrillators: The of the CharlsonIndex Co-morbidity Enduring Value Predicts MortalitySpatial QRS-T Angle in Chronic Dialysis Patients Prognosis Heart Systematic Inflammation and Rate, Atrial Fibrillation with Persistent in Patients 1244-135 Anas Moulin Chokshi, Jason Ng, Leonard Ilkhanoff, Patel, Ravi Bhojraj, Sanjay Haris Subacius, Satish Jacob Chacko, Mouchli, Northwestern University Alan H. Kadish, J. Goldberger, Jeffrey IL Chicago, School of Medicine, Feinberg Learning morphological Objective: distinguish the various types of and interpret their clinical significance with resepct J-point elevation, infarctions. acute myocardial experienced to patients who have 1244-136 Lorraine J. Psaltis, Peter Angelo Carbone, Dennis H. Lau, Christopher X. Wong, Kuklik, Robert Pawel Metcalf, Mackenzie, Michael J. A. Saint, David G. Brooks, Anthony Adam J. Nelson, Prashanthan Sanders, Stephen G. Worthley, Young, Glenn D. James, Adelaide, Hospital, Adelaide The University of Adelaide & Royal Australia Learning Objective: appreciate the beneficial atrial effects of PUFAs in chronic heart failure 1244-131 Alfred Danette Guertin, Craig I. Coleman, Bhavnani, P. Sanjeev Jeffery A. Clyne, Kluger, Christopher K. Yarlagadda, Ravi Danielian, CT Hartford Hartford, Hospital, prognostic impact of the Charlson identify the Learning To Objective: prediction of earlyco-morbidity index in the mortality after ICD implantation 1244-132 Roderick W.C. Andre Gaasbeek, Elsbeth Belt, Mihaly K. de Bie, J. Rabelink, Ton Martin J. Schalij, Cees A. Swenne, Scherptong, The Leiden, Leiden University Medical Center, Jukema, J. Wouter Netherlands assess the mortality risk of a dialysis patient Learning Objective: To the 12 lead ECG based on the spatial QRS-T angle derived from 1244-133 Akihiro Saito, Ken Maehama, Tomoko Okura, Hiroyuki Imai, Koichiro Medical School, Kawasaki Kiyoshi Yoshida, Neishi, Yoji Hayashida, Japan Kurashiki, Learning atrial Objective: Interpret relationship between the heart fibrillation , rate and C-reactive protein Presence of Fragmented Wide- QRS Complex Presence of Fragmented and the Risk of Death and Sudden Cardiac Death with Left Bundle Branch II Patients among MADIT- Block. Epidemiology of P Wave Indices in Healthy Post- Indices in Healthy Epidemiology of P Wave Health Initiative The Women’s Menopausal Women: ECG - RISK STRATIFICATION FOR CLINICAL ECG - RISK STRATIFICATION EVENTS 9:30 a.m. - 12:30 p.m. 2010, March 16, Tuesday, Hall B5 Congress Center, Georgia World Presentation Hour: a.m. - 10:30 a.m. 9:30 CME/CE Hours: 1 Early During Exercise Repolarization is Attenuated and Recovery Volunteers in Healthy Initial Experience of the Novel Mobile Telemedicine Mobile Telemedicine the Novel Initial Experience of of Prehospital System in Real-Time Transmission Cardiac Emergency 12-lead ECG for Magnetocardiography Can Idenfity ‘Local’ Can Idenfity ‘Local’ Magnetocardiography LV with Patients in Delay Conduction Ventricular on ECG: Comparison and CLBBB/IVCD Dysfunction CLBBB with ‘Isolated’ Grzegorz M. Pietrasik, Slava Polonsky, Arthur J. Moss, Wojciech Wojciech Arthur J. Moss, Polonsky, Slava Grzegorz M. Pietrasik, University of Rochester, Heart Program, Zareba, Research Follow-Up NY Rochester, Learning Objective: At the conclusion of ths presentation, participants will be able to identify higher risk patient with LBBB based on baseline ECG, and ischemic cardiomyopathy 1244-130 Eiran Z. Gorodeski, Jared W. Magnani, Ronald J. Prineas, Mara Z. Ronald J. Prineas, Magnani, Jared W. Eiran Z. Gorodeski, Martin, Lisa W. Z. Soliman, Mary Elsayed Vitolins, J. O’Sullivan, Eugene Barbara B. Cochrane, Curb, J. David Marian C. Limacher, OH, Cleveland, Clinic, Cleveland Michael S. Lauer, H. Blackstone, MA Boston, Boston University School of Medicine, Learning Objective: Describe the prognostic importance of P wave women with normal resting ECGs. indices in healthy 1244-129 1244 David McNamara, Shiraaz Rahman, Jason Ng, Leonard Ilkhanoff, Leonard Ilkhanoff, Jason Ng, Shiraaz Rahman, McNamara, David Northwestern Alan H. Kadish, J. Goldberger, Jeffrey Vinod Sehgal, IL Chicago, University, Learning of exercise and recovery Objective: Describe the effects on earlyrepolarization 1243-127 Nobuhito Yagi, Yoritaka Otsuka, Yukiko Oe, Takafumi Yamane, Yamane, Takafumi Oe, Yukiko Otsuka, Yoritaka Nobuhito Yagi, Hiroyuki Kataoka, Yu Kasahara, Yoichiro Eiji Tada, Futoshi Yamanaka, Japan Suita, Cneter, National Cardiovascular Hiroshi Nonogi, Yokoyama, System Learning Objective: Mobile Telemedicine 1243-126 Shogo Oishi, Sr., Hiroshi Takaki, Shuji Hashimoto, Wataru Shimizu, Shimizu, Wataru Shuji Hashimoto, Takaki, Hiroshi Sr., Shogo Oishi, Department of Cardiology, Shiro Kamakura, Masaru Sugimachi, Department Japan, of Suita, center, National Cardiovascular Center Research National Cardiovascular Dynamics, Cardiovascular Japan Suita, Institute, Learning identify minute peripheral ventricular conduction Objective: in patients with LV damage myocardial by disturbance accompanied Magnetocardiography on ECG by dysfunction and with CLBBB/IVCD non-invasively. 1243-125 JACC March 9, 2010 2010 9, March JACC Cardiac Arrhythmias death for prevention ofsudden Objective:useofbiomarkers Learning Piergiorgio Golzio, Francesco Accardi, CatholicUniversity, rome, Italy Antoine Kheir, GabrieleZaccone, Achilli, Filippo MarcelloPiacenti, Serafino Orazi, MassimoSassara, AntonioCastro, RiccardoMassa, Luigi M.Biasucci, FulvioBellocci, MaurizioLandolina, Crea, Filippo 1245-142 implantation. study onthesameday ofimplantablecardioverter-defibrillator electrophysiology Objective:Identifytheriskofperforming Learning University, Omaha, NE Pasupuleti, MaheshAlla, Kelly Airey, NazihKadri, Creighton Madhu Reddy, SenthilThambidorai, ManuKaushik, Suman 1245-141 and ICDs. failure inpatientswithheart inappropriate ICDshocksandmortality forappropriateand Objective:knowriskfactors Learning ofTexasUniversity Southwestern MedicalCenteratDallas, Dallas, TX Cohen, Sorbera, Carmine New York MedicalCollege, Valhalla, NY, Hussain, HoangM.Lai, MalaSharma, WilliamH.Frishman, Martin S.Aronow,Wilbert HaritDesai, KaushangGandhi, ChulAhn, Sadaf 1245-140 prevention ICDpatients primary riskscoreinischemic Implementation ofaneasy-to-usemortality Objective:applyaneasy-to-usemordemonstratethatthe Learning Netherlands Bax, J.Schalij, MedicalCenter, Martin Leiden University Leiden, The van derWall, Johanna G.vanderBom, Frits R.Rosendaal, JeroenJ. H. Welsenes, RutgerJ.vanBommel, E. LieselotvanErven,Ernst Joep Thijssen, C.JanWillem Borleffs, JohannesB.vanRees, Guido 1245-138 lead recallonICDimplantvolume Objective:DescribetheimpactofMedtronicFidelis Learning SchoolofMedicine,University New Haven, CT Paras S.Bhatt, JepthaCurtis,Yongfei Wang, RachelLampert,Yale 1245-137 1245 A14 Patients: ResultsOfTheCamiGuideStudy. Defibrillator Protein InImplantableCardioverter Prognostic RoleOfPost-infarction C-Reactive Electrophysiology Study ontheSameDay of Cardioverter-Defibrillator Complications ofImplantingImplantable Defibrillators Failure andImplantableCardioverter- with Heart Defibrillator Shocks,in549 Patients andMortality Defibrillator Shocks, InappropriateCardioverter- Risk Factors for AppropriateCardioverter- Easy ApplicableRiskScore Disease:An ICD RecipientswithIschemicHeart Prevention RiskinPrimary Prediction ofMortality Data fromtheNCDRICDRegistry Defibrillators: Utilization ofImplantableCardioverter LeadRecallon Impact oftheMedtronicFidelis 1 CME/CE Hours: 9:30a.m.-10:30 Presentation Hour: Georgia World CongressCenter, HallB5 Tuesday, March16, 2010, 9:30a.m.-12:30p.m. ANTIARRHYTHMIA DEVICES DEFIBRILLATION/IMPLANTABLE ABSTRACTS: Cardiac Arrhythmias ICD therapy prevention Objective:Identifyracialdifferencesinprimary Learning MD, Washington HospitalCenter, Washington, DC Alan Cheng, SchoolofMedicine, JohnsHopkinsUniversity Baltimore, Hugh Calkins,G.Weiss, Robert EliseoGuallar, GordonF. Tomaselli, Joseph E.Marine, David D. Spragg, SunilK.Sinha, RonaldD. Berger, Singh, Dalal, Darshan BarbaraButcher, ManishH.Shah, EricBukata, Kennedy,Robert YiyiZhang, SameerGafoor, MansourMehdi, Bharat 1245-144 dysfunction. cardiac deathandbody-massindexinpatientswithleftventricular Objective:DescribetherelationshipbetweenLearning sudden of Medicine, ofRochesterMedicalCenter, University Rochester, NY Implantation Trial-II Investigators, UnitoftheDepartment Cardiology Zareba, IlanGoldenberg, MulticenterAutomaticDefibrillator Eric D. Hansen, BonnieChoy, J.Moss, Arthur ScottMcNitt, Wojciech 1245-143 it toclinicalstatus with atrialfibrillationorbradycardiatachycardia syndromeandrelate Objective:AnalysepacemakerLearning diagnosticdatainpatients Brunswick, NJ Research Foundation, Warren, NJ, UMDNJ-RWJ MedicalSchool, New Koehler, AndreaGrammatico, LuigiPadeletti, Electrophysiology Rangadham Nagarakanti, Sanjeev Saksena, Douglas Hettrick, Jodi 1246-147 ofatrial fibrillation. atrial sizeinrelationtotherecurrence theimpactofcatheterablationonleft Objective:interpret Learning Center,Sakurabashi-Watanabe Hospital, Osaka, Japan Takashi Takagi, Daisuke Morisawa, Kenshi Fujii, Cardiovascular Ozawa, Yukinori Okazaki, Masahiko Shibuya, ShigemikiOmiya, Koyama, Motoo Date, Yoshiharu Higuchi, Hiroyuki nagai, Makito Norihisa Ito, KatsuomiIwakura, Atsunori Okamura, Yasushi Yuko Toyoshima, Koichi Inoue, Toshiya Kurotobi, Ryusuke Kimura, 1246-146 1246 Findings FromFindings thePROSE-ICD Study DefibrillatorTherapy: Implantable Cardioverter Prevention Racial Differences inPrimary Left Ventricular Dysfunction andDefibrillatorEfficacyin PatientsWith Mortality Relation ofBodyMassIndextoSuddenCardiac Insights Classifications withImplantableDevice Datalog Clinical Correlating Persistent AtrialFibrillation: Progression fromNew OnsettoEstablished Ventricular FunctionandRecurrence ItsImpactonLeft Ablation toAtrialFibrillation: RemodelingofLeftAtriumafterCatheter Reverse 1 CME/CE Hours: 9:30a.m.-10:30 Presentation Hour: Georgia World CongressCenter, HallB5 Tuesday, March 16, 2010, 9:30a.m.-12:30p.m. FIBRILLATION ECG/AMBULATORY MONITORING-ATRIAL JACC March 9, 2010 Cardiac Arrhythmias ABSTRACTS: Cardiac Arrhythmias Cardiac ABSTRACTS: A15 Detecting Atrial FibrillationDetecting a Novel at Home with Fibrillation Monitor with Atrial Blood Pressure Functionality Detection Carvedilol Attenuates Atrial Fibrillation Promotion via Antioxidant Properties Atrial in Dogs with Remodeling Tachycardia 1246-152 Inc, USA, Microlife C. Messineo, Frank Abraham, Saji Joseph Wiesel, NY York, New Lenox Hill Hospital, FL, Dunedin, Learning Determine Objective: fibrillation can if asymptomatic atrial blood patients using a novel at home by be accurately detected fibrillation detection functionality. presure monitor with atrial 1246-153 Morikawa, Tomoko Shiroshita-Takeshita, Akiko Motoda, Hiroyuki Shingo Hori, Masaru Suzuki, Abe, Shinya Sekine, Kazuhiko Japan, Tokyo, University Medicine, School of Keio Satoshi Ogawa, Tokyo, Mita Hospital, International University of Health and Welfare Japan Learning of atrial fibrillation Objective: identify the pathophysiology fibrillation possible therapeutic approaches to atrial and the novel Characteristics of Atrial Substrate and Inducibility Characteristics of Atrial Substrate and Inducibility Atrial Fibrillation for in Hypercholesterolemia Rabbits Does Atrial Fibrillation-induced Left Atrial Dysfunction? Valve Remodeling Cause Mitral Patent Foramen Ovale Closure with a Conventional a Conventional Ovale Closure with Foramen Patent Ablation Catheter:Radiofrequency Early Feasibility 1246-150 Kaohsiung Medical University Hospital, Lai, Wen-Ter Lee, Kun-Tai Taiwan,ROC Kaohsiung, Learning of atrial Objective: deonstratre the characteristics rabbits substrate for atrial fibrillation in hypercolesterolemia Laszlo Saghy, Martin G. Keane, David J. Callans, Frank E. Silvestry, E. Silvestry, Frank J. Callans, David Martin G. Keane, Laszlo Saghy, PA Philadelphia, Philadelphia PA, University of Pennsylvania, atrial Learning identify a potential relationship between Objective: atrial remodelling and mitral regurgitation. fibrillation induced left 1246-149 Luigi Di Biase, J. David Burkhardt, Rodney Horton, Javier Sanchez, Sanchez, Horton, Javier Rodney Burkhardt, J. David Luigi Di Biase, G. Shane Bailey, Dimpi Patel, Mitra Mohanty, Prasant Mohanty, Medical Center, St. David’s Andrea Natale, Joseph Gallinghouse, TX Austin, Learning if energy evaluate Objective: delivery via the 3.5 mm with PFO is a good strategyablation catheter in patients to obtain PFO closure 1246-148 JACC March 9, 2010 2010 9, March JACC A16 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

ORAL CONTRIBUTIONS

910 EFFECTS OF NOVEL AGENTS ON VENTRICULAR 913 NOVEL ELECTRICAL STIMULATION THERAPIES IN FUNCTION HEART FAILURE Monday, March 15, 2010, 2:00 p.m. - 3:30 p.m. Monday, March 15, 2010, 4:30 p.m. - 6:00 p.m. Georgia World Congress Center, Room B408 Georgia World Congress Center, Room B408 CME/CE Hours: 1.5 CME/CE Hours: 1.5

2:00 Acute Intravenous Bolus Injection of Poloxamer-188 4:30 Right Vagus Nerve Stimulation Improves Left Improves Left Ventricular Function in Dogs with Ventricular Function in Dogs with Heart Failure Heart Failure Hani N. Sabbah, Mengjun Wang, Alice Jiang, Stephen B. Ruble, Itamar Ilsar, Mengjun Wang, Alice Jiang, Kaitlin Dye, Bruce Jason J. Hamann, Henry Ford Hospital, Detroit, MI, Boston Scientific Markham, Hani N. Sabbah, Henry Ford Hospital, Detroit, MI, Phrixus Corp., St. Paul, MN Pharmaceuticals, Ann Arbor, MI Learning Objective: Evaluate the effects of Vagus Nerve Stimulation Learning Objective: Describe the effects of injection of poloxamer on LV function in dogs with heart failure -188 on LV function in dogs with experimental heart failure. 4:45 Transvenous Vagus Nerve Stimulation: A Potential 2:15 Cinaciguat, a Soluble Guanylate Cyclase Activator, Heart Failure Therapy Is Feasible in Humans Unloads the Heart in Acute Decompensated Heart Katherine Fan, Raymond Yee, Lorna Gula, Cathy Bentley, Avram

Cardiac Function and Heart Failure Failure Scheiner, Sum Lam, Macrina Wong, Maria Parke, Ruth Nicholson Erland Erdmann, Marc J. Semigran, Markku S. Nieminen, Rahul Klepfer, Allan Skanes, Grantham Hospital, Aberdeen, , Agrawal, Veselin Mitrovic, Alexandre Mebazaa, Universität zu Köln, London Health Sciences Center, London, ON, Canada Medizinische Klinik III, Cologne, Germany Learning Objective: describe the current thresholds required for Learning Objective: evaluate the therapeutic potential of laryngeal vibration when stimulating the vagus nerve from the IJV. cinaciguat, which is being developed as a new treatment for acute describe the relationship between cervical location and laryngeal decompensated heart failure with a novel mode of action. vibration threshold.

2:30 Effect Of N-3 Polyunsaturated Fatty Acids and 5:00 Chronic Vagal Nerve Stimulation Impacts Rosuvastatin on Left Ventricular Function in Patients Biomarkers of Heart Failure in Canines with Chronic Heart Failure. A Substudy of the Gissi- Stephen B. Ruble, Jason J. Hamann, Ramesh C. Gupta, Sudhish hf Trial Mishra, Hani N. Sabbah, Henry Ford Hospital, Detroit, MI, Boston Stefano Ghio, Laura Scelsi, Ermanno Eleuteri, Michela Palvarini, Scientific Corp., St. Paul, MN Olga Vriz, Serge Masson, Renato Urso, Roberto Latini, Michele Learning Objective: Describe the effects of Vagus nerve stimulation Pasotti, Gianni Tognoni, Luigi Tavazzi, Stefano Ghio, Pavia, Italy on biomarkers of heart failure Learning Objective: better interpret the effects of N-3 pufa in patients with chronic heart failure 5:15 Low Amplitude Vagus Nerve Stimulation Affects Heart Rate and Neurohormones in Humans

2:45 Long-Term Therapy with Rosuvastatin Increases Katherine Fan, Raymond Yee, Lorna Gula, Cathy Bentley, Avram Protein Expression of Growth Factors and Stem Cell Scheiner, Sum Lam, Macrina Wong, Maria Parke, Ruth Nicholson Markers in Left Ventricular Myocardium of Dogs Klepfer, Allan Skanes, Grantham Hospital, Aberdeen, Hong Kong, with Moderate Heart Failure London Health Sciences Center University Hospital, London, ON, Canada Sharad Rastogi, Michael S. Sabbah, Sudhish Mishra, Kaitlin Dye, Andrew Cavanagh, Hani N. Sabbah, Henry Ford Hospital, Detroit, MI Learning Objective: describe the effects of low amplitude transvenous stimulation of the vagus nerve in humans. Learning Objective: Evaluate the potential role of statins in improving LV function in heart failure. 5:30 Sustained Benefit at One Year Follow-Up from Transapical Left Ventricular Endocardial Pacing for Pioglitazone Affects Left Ventricular Filling Pressure 3:00 End Stage Heart Failure in Patients with Ischemic Heart Disease and Type 2 Diabetes Who Underwent Coronary Intervention: Attila Mihalcz, Imre Kassai, Csaba Foldesi, Attila Kardos, An Echo Doppler Sub-Analysis from the Prevention Tamas Szili-Torok, Hungarian National Institute of Cardiology, of In-Stent Neointimal Proliferation by Pioglitazone Budapest, Hungary, Thoraxcentre, Department of Clinical Cardiac Study (POPPS) Electrophysiology, Erasmus MC, Rotterdam, The Netherlands

Hiroyuki Okura, Tsutomu Takagi, Iku Toda, Bell Land General Learning Objective: Our data demonstrate that transapical Hospital, Sakai, Japan, Takagi Cardiology Cinic, Kyoto, Japan endocardial CRT is a feasible alternative for patients in whom percutaneous delivery of the LV pacing lead fails. Learning Objective: investigate impact of pioglitazone on left ventricular diastolic function and filling pressure in patients with ischemic heart disease JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A17

916 MYOCARDIAL RECOVERY/REVERSE 922 CIRCULATING BIOMARKERS IN HEART FAILURE REMODELING Tuesday, March 16, 2010, 2:00 p.m. - 3:30 p.m. Tuesday, March 16, 2010, 8:00 a.m. - 9:30 a.m. Georgia World Congress Center, Room B211 Georgia World Congress Center, Room B408 CME/CE Hours: 1.5 CME/CE Hours: 1.5 2:00 Plasma Galectin-3 Levels Predict Left Ventricular 8:00 Impact of Reduction in Functional Mitral Remodelling Determined by Sequential

Regurgitation on Left Ventricular Reverse Echocardiography: Results from the Deventer- FailureCardiac Function and Heart Remodeling after Cardiac Resynchronization Alkmaar Heart Failure Study Therapy Dirk Lok, Peter van der Meer, Pieta Bruggink Andre de la Porte, Eric Yu-Jia Liang, Qing Zhang, Gabriel WK Yip, Alex PW Lee, Yat-Yin Lam, Lipsic, Jan van Wijngaarden, Yigal Pinto, Dirk Jan van Veldhuisen, Fang Fang, Cheuk-Man Yu, The Chinese University of Hong Kong, Deventer Hospital, Deventer, The Netherlands, University Medical Hong Kong, Hong Kong, West Hospital, Sichuan University, Centre Groningen, Groningen, The Netherlands Chengdu, Sichuan, People’s Republic of China Learning Objective: understand the value of measuring Galectin-3 Learning Objective: understand the positive impact of reduction in as a novel marker for remodeling in heart failure functional MR on LV reverse remodeling after CRT. 2:15 Troponin I Is Chronically and Persistently Elevated 8:15 Relationship of QRS Morphology on Reverse in Hospitalized Heart Failure Patients and Is Remodeling and Clinical Outcomes with Cardiac Associated with Increased Mortality Over Five Years Resynchronization Therapy (CRT) in Mild Heart Ravi S. Hira, Maithili Shenoy, Omid Fatemi, Mariana Bolos, Wenyaw Failure: Results from the REsynchronization Chan, Biykem Bozkurt, Baylor College of Medicine, Houston, TX, reVErses Remodeling in Systolic left vEntricular Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX Dysfunction (REVERSE) trial Learning Objective: Describe the prevalence of chronic persistence Michael Robert Gold, Cecilia Linde, Angel Arenal Maiz, Jean-Claude of Troponin I elevation and it’s association with higher mortality over Daubert, William T. Abraham, Medical University of South Carolina, 5 years. Charleston, SC Learning Objective: Evaluate the importance of QRS morphology as 2:30 Small Troponin Elevations in Heart Failure a predictor of reverse remodeling with CRT Exacerbation Patients Are Associated with Increased 90-Day Mortality

8:30 Persistent Intraventricular Dyssynchrony Impairs Yang Xue, Alan S. Maisel, VA San Diego Healthcare System, San Left Ventricle Systolic Function During Acute Diego, CA, University of California San Diego, San Diego, CA Withdrawal of Cardiac Resynchronization Therapy in Patients with Extensive Left Ventricle Reverse Learning Objective: Demonstrate that small troponin elevations can lead to increased mortality in patients with heart failure Remodeling exacerbation. Radu-Gabriel Vatasescu, Alexandra Vasile, Corneliu Iorgulescu, Dana Constantinescu, Diana Zamfir, Maria Dorobantu, FACC, FESC, Clinic 2:45 St2 for Stratifying Preserved Ejection Fraction Emergency Hospital, Bucharest, Romania Patients with Shortness of Breath

Learning Objective: to identify a specific mechanism of disease in Christopher R. DeFilippi, Keyur Shah, Robert Christenson, Sue super-responders to CRT Hender, Willem Kop, University of Maryland, Baltimore, MD

Reversing Left Ventricular Remodeling: Acute Learning Objective: Identify the prognostic role for ST2 in dyspnea 8:45 patients with preserved LVEF Results from Epicardial Catheter-based Ventricular Reconstruction in an Ovine Heart Failure Model 3:00 Increased 90-Day Mortality in Patients with Yanping Cheng, Michael Aboodi, Andrew Wechsler, Gerard Conditt, Diane Elevated Copeptin: Secondary Results from the Ordanes, Alyssa Flynn, Greg L Kaluza, Juan F Granada, Lon S Annest, Biomarkers in Acute Heart Failure (BACH) Study Geng-hua Yi, Cardiovascular Research Foundation, Orangeburg, NY Yang Xue, Kevin Shah, Alan S. Maisel, VA San Diego Healthcare Learning Objective: To evaluate the acute reduction in left System, San Diego, CA, Charite, Campus Virchow-Klinikum, Berlin, ventricular volume achieved with a minimally invasive device for Germany epicardial catheter-based ventricular reconstruction in an ovine heart failure model Learning Objective: Demonstrate that elevated copeptin levels are associated with increased mortality in heart failure patients. 9:00 Echocardiographic Predictors of Recovery of Left Ventricular Ejection Fraction after Renal Transplant

Poh Shuan Daniel Yeo, Carmel M. Halley, Richard Fatica, WH Wilson Tang, Tan Tock Seng Hospital, Singapore, Singapore, Cleveland Clinic, Cleveland, OH Learning Objective: In patients with impaired LVEF and end-stage renal failure, baseline LVEF is a simple predictor of recovery of LVEF after renal transplant A18 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

POSTER CONTRIBUTIONS

1010 LEFT VENTRICULAR ASSIST DEVICES-- 1011 LEFT VENTRICULAR ASSIST DEVICES-- CLINICAL METABOLIC AND CLINICAL ASPECTS INSIGHTS Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1010-35 Improved Glucose Utilization and Mitochondrial 1011-41 Patients with End-Stage Heart Failure Can be Safely Function Following Left Ventricular Assist Device Discharged Home on Biventricular Assist Devices to Support Await Transplant

Dale J. Hamilton, Norma E. Vazquez, Keith A. Youker, Ahmad Khalil, Jessica L. Ackerman, Colleen M. Smith, Leslie M. Griffin, Gregory Anisha A. Gupte, Willa A. Hsueh, Guillermo Torre-Amione, The S. Couper, Michael M. Givertz, Brigham and Women’s Hospital, Methodist Hospital Research Institute, Houston, TX Boston, MA Learning Objective: Distinguish Pre and Post-LVAD metabolic gene Learning Objective: Describe common complications and reasons expression. for re-hospitalizations in BiVAD and LVAD patients

1010-36 Factors Influencing Hospital LOS Following 1011-42 Increased Incidence of Aortic Insufficiency in

Cardiac Function and Heart Failure Successful LAVD Therapy HeartMate II Compared to HeartMate I Left Ventricular Assist Device Recipients Yan Topilsky, barry boilson, kiick sung, lucian durham, richard daly, sudir kushwaha, naveen pereira, soon park, mayo clinic, rochester, MN Sang-Woo Pak, Nir Uriel, Hiroo Takayama, Sarah Cappleman, Paolo C. Colombo, Donna Mancini, Yoshifumi Naka, Ulrich P. Jorde, Learning Objective: Identify patients for LVAD referral Columbia University, New York, NY 1010-37 Increased Insulin Sensitivity in Advanced Heart Learning Objective: Discribe AI development during continuous flow Failure Patients Treated with Left Ventricular Assist device support. Device 1011-43 Have LVADs Rendered Fixed Pulmonary nir uriel, Sang-Woo Pak, Paolo Colombo, Vlad Cotarlan, Maryjane Hypertension In Heart Failure A Vestige Of The Farr, Donna Mancini, Yoshifumi Naka, Yoshifumi Naka, Ulrich P. Past? Jorde, Columbia University, New York, NY Barry A. Boilson, John A. Schirger, Yan Topilsky, Lucian A. Durham, Learning Objective: Demonstrate improved insulin sensitivity in III, Sudhir S. Kushwaha, Lyle D. Joyce, Richard C. Daly, Soon J. Park, advanced heart failure patients who underwent LVAD implantation. Mayo Clinic, Rochester, MN 1010-38 Changing Cost-Effectiveness of Left Ventricular Learning Objective: To understand the potential of LVAD therapy to Assist Devices as Destination Therapy treat “fixed” pulmonary hypertension in severe heart failure.

Mark J. Russo, Annetine Gelijns, Keith Aaronson, Leslie Miller, 1011-44 High Prevalence of Bleeding with Continuous Flow Kimberly Hong, Mehmet Oz, Deborah Ascheim, Frank Pagani, Devices Yoshifumi Naka, Eric Rose, Alan Moskowitz, Mount Sinai Medical Center, New York, NY, Columbia University, New York, NY nir uriel, Sang-Woo Pak, Hiroo Takayama, Robert Song, Yoshifumi Naka, Ulrich P. Jorde, Donna Mancini, Columbia University, New Learning Objective: To highlight how substantial changes in York, NY technology and its application can significantly impact clinical and economic endpoints Learning Objective: Describe major bleeding events during HeartMate II LVAD support and identify acquired von Willebrand 1010-39 Implantation of Ventricular Assist Devices to disease in those patients. Mediate Weight Loss in Obese Heart Failure Patients 1011-45 Changing Trends In Mechanical Circulatory Assistance: A Single Center Experience Pavittarpaul Dhesi, Faramarz Tehrani, Sriran Simsir, Lawrence Czer, Ernst Schwarz, Cedars Sinai Medical Center, Los Angeles, CA Veli K. Topkara, Sreekanth Kondareddy, I-Wen Wang, Douglas L. Mann, Gregory A. Ewald, Nader Moazami, Washington University in Learning Objective: Evaluate the role of using left ventricular assist St. Louis, St. Louis, MO devices in obese patients with advance heart failure Learning Objective: Distinguish pulsatile and continuous flow assist devices and their mid-term clinical outcomes JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A19

1012 CARDIAC TRANSPLANTATION--BASIC AND 1012-51 Is Stress Myocardial Perfusion Imaging with CLINICAL Regadenoson, A New Pharmacologic Stress Agent, Safe in Orthotopic Heart Transplant Patients? First Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Report of Regadenoson, A Selective A2a Receptor Georgia World Congress Center, Hall B5 Agonist in the Heart Transplant Population Presentation Hour: 9:30 a.m. - 10:30 a.m. Joao L. Cavalcante, Mouaz Al-Mallah, Cristina Tita, David CME/CE Hours: 1 Lanfear, Celeste Williams, Barbara Czerska, Karthikeyan Ananthasubramanian, Henry Ford Hospital - Heart and Vascular 1012-47 Inhibition of Angiotensin Signaling Reduces Institute, Detroit, MI FailureCardiac Function and Heart Incidence of Antibody Mediated Allograft Rejection. Learning Objective: Describes safety and feasibility of new Sanjay K. Shah, Divya Ratan Verma, Greg Snow, Abadallah G. pharmacological stress agent - Regadenoson - in heart transplant Kfoury, Feras Bader, Kim Brunisholz, Stavros G. Drakos, Elizabeth patients ME Hammond, Monica P. Revelo, Edward Gilbert, Rami Alharethi, Deborah Budge, Melanie D. Everitt, Craig Selzman, Josef Stehlik, UTAH Cardiac Transplant Program, Salt Lake City, UT 1013 MYOCARDIAL FUNCTION/HEART FAILURE--- BASIC/MOLECULAR--TISSUE ENGINEERING 1012-48 Effect of Everolimus Introduction and Calcineurin Inhibitor Reduction on Graft Vasculopathy in Heart Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Transplant Recipients Georgia World Congress Center, Hall B5 Satish Arora, Bertil Wennerblom, Bengt Rundqvist, Hans Eiskjær, Presentation Hour: 9:30 a.m. - 10:30 a.m. Hans Bøtker, Svend Aage Mortensen, Kari Saunameki, Bjørn CME/CE Hours: 1 Ekmehag, Kjell Janssson, Svein Simonsen, Einar Gude, Knut Endresen, Dag Solbu, Lars Gullestad, Oslo University Hospital 1013-52 Cardiospheres and Tissue Engineering for Rikshospitalet, Oslo, Norway Myocardial Regeneration: Potential for Clinical Learning Objective: evaluate the effect of everolimus introduction Application and calcineurin inhibitor reduction on graft vasculopathy in heart Mariangela Peruzzi, Giacomo Frati, Ilaria Chirichilli, Ursula Tuderti, transplant recipients Giuseppe Pugliese, Juan Carlos Chachques, Massimo Ricci, Federica Papetti, Andrea Marcantonio, Chiara Santo, University 1012-49 Risk of Stroke and Death in Patients with of Rome Sapienza Cardiac Surgery Unit Polo Pontino, Rome, Symptomatic Cerebrovascular Disease Undergoing Italy, 3Department of Experimental Medicine University of Rome Heart Transplantation: An Analysis of the United Sapienza, Rome, Italy Network for Organ Sharing Registry Learning Objective: identify the best complex to achieve myocardial Vishnu Patlolla, Vanajakshi Mogulla, Benjamin Kalsmith, David regeneration DeNofrio, Rajan Krishnamani, Tufts Medical Center, Boston, MA, UMass Medical Center, Worcester, MA 1013-53 Protective Effect of BBTMH-007 on Development of Cardiomyopathy Learning Objective: To describe the effect of symptomatic cerebrovascular disease on outcomes in patients undergoing heart Guillermo Torre-Amione, Keith A. Youker, Ahmad Khalil, Jose Flores- transplantion Arredondo, Sergio Serna, Jorge Moreno, Jerry D. Estep, Guillermo Torre-Amione, The Methodist Hospital, Houston, TX, The Methodist 1012-50 Desensitization of Highly HLA-Sensitized Heart DeBakey Heart & Vascular Center, Houston, TX Transplant Candidates Using High-Dose Intravenous Learning Objective: Demonstrate the effect of BBTMH007 on Immunoglobulin and Rituximab with Successful nonischemic cardiomyopathy Transplantation

Lawrence S. C. Czer, Bernice Coleman, Sinan Simsir, Ernst R. 1013-56 Angiotensin Receptor Blockers Improved Schwarz, Chih-Hung Lai, Kai Cao, Stanley Jordan, Ashraf Osman, Cardiomyogenic Transdifferentiation Efficiency of Gina Jamero, Anita Phan, Matthew Rafiei, Nancy Reinsmoen, Human Marrow-derived Mesenchymal Stem Cells in Cedars-Sinai Medical Center, Los Angeles, CA vitro

Learning Objective: determine that desensitization with intravenous Yohei Numasawa, Shunichiro Miyoshi, Takehiro Kimura, Nobuhiro immunoglobulin and rituximab may allow cardiac transplantation in Nishiyama, Hiroko Tsuji, Naoko Hida, Daisuke Shinmura, Hikaru highly sensitized patients. Nakamizo, Ikuko Togashi, Kaoru Segawa, Akihiro Umezawa, Satoshi Ogawa, Keio Univsersity School of Medicine, Tokyo, Japan Learning Objective: To learn favorable effect of ARBs on the caridomyogenic transdifferentiation efficiency of human marrow- derived mesenchymal stem cells (MSCs) A20 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1013-57 Tumor Necrosis Factor Alpha Induces the 1014-65 A Polymorphism in the PDE3A Gene Promoter that Differentiation of Bone Marrow Stem Cells into Prevents cAMP-Induced Increases in Transcriptional Cardiomyocytes Activity, and May Protect Against PDE3A inhibitor Drug Tolerance. Mayra E. Guerrero, Sharad Rastogi, Sudhish Mishra, Ramesh C. Gupta, Hani N. Sabbah, Henry Ford Hospital, Detroit, MI Michael R. Bristow, Matthew RG Taylor, Dobromir Slavov, Penny L. Blain-Nelson, Karin R. Nunley, Allen M. Medway, Carmen C. Learning Objective: Describe the cardiomyogenic effect of tumor Sucharov, University of Colorado Denver; CU Cardiovascular necrosis factor alpha on adult bone marrow mesenchymal stem Institute, Aurora, CO cells in chronic heart failure Learning Objective: Identify and interpret Mechanisms of drug 1013-58 Diastolic Dysfunction Induced By Mild Hypothermia action and mechanisms of drug tolerance Alters Left Ventricular Filling In A Porcine Model 1014-67 Myocardial Tissue Levels of Protein Arginine Andreas W. Espinoza, Helge Skulstad, Viesturs Kerans, Per Steinar N-Methyltransferase 1 (PRMT-1) and Halvorsen, Jacob Bergsland, Jan Fredrik Bugge, Thor Edvardsen, Dimethylarginine Dimethylaminohydrolase-1 (DDAH- Rikshospitalet Oslo University Hospital, Oslo, Norway 1) in the Human Failing Heart are Influenced by Learning Objective: describe the effects on diastolic properties Raised Intracardiac Filling Pressures and LV filling from mild hypothermia as used in post-resuscitation treatment Zhili Shao, Wendy E. Sweet, Matthew Baumann, Christine S. Moravec, Wai Hong Wilson Tang, Cleveland Clinic, Cleveland, OH

1014 MYOCARDIAL FUNCTION/HEART FAILURE--- Learning Objective: To describe the myocardial deterimants of

Cardiac Function and Heart Failure methylarginine accumulation in advanced heart failure BASIC/MOLECULAR--MYOCARDIAL FUNCTION Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. 1014-68 Erythropoietin Receptor Deficient Mice Have Georgia World Congress Center, Hall B5 Impaired Cardiac Adaptation During Voluntary Presentation Hour: 9:30 a.m. - 10:30 a.m. Exercise CME/CE Hours: 1 Willem-Peter T. Ruifrok, Laura M. Meems, B. Daan Westenbrink, Alexander H. Maass, Herman H. Sillje, Dirk J. van Veldhuisen, Wiek 1014-61 Hydrogen Sulfide Therapy Attenuates Ischemia- H. van Gilst, Rudolf A. de Boer, University Medical Center Groningen, Induced Heart Failure via Nrf2 and NRF1 Signaling Groningen, The Netherlands

John W. Calvert, Marah Elston, Saurabh Jha, Susheel Gundewar, Learning Objective: appreciate the physiology behind cardiac Juan Pablo Aragon, David Bennett Grinsfelder, Arun Ramachandran, adaptation during exercise John W. Elrod, David J. Lefer, Emory University School of Medicine, Atlanta, GA 1015 MYOCARDIAL FUNCTION/HEART FAILURE-- Learning Objective: identify a role for Nrf2 signaling in hydrogen -BASIC/MOLECULAR--DIVERSE SIGNALING sulfide-mediated protection against experimental heart failure PATHWAYS

1014-62 Constitutive GSK-3 Activity Permits Adaptive Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Myocardial Remodelling And Maintains Adrenergic Georgia World Congress Center, Hall B5 Sensitivity With Chronic Isoproterenol Stimulation Presentation Hour: 9:30 a.m. - 10:30 a.m. Ian G. Webb, James Clark, Colin Murdoch, Ajay Shah, Michael CME/CE Hours: 1 Marber, King’s College London BHF Centre, London, United Kingdom 1015-69 Galectin-1 Deficient Mice Have Abnormal Baseline Learning Objective: To understand better the role of role of GSK-3 Cardiac Function And Worse Remodeling After signalling in cardsiac hypertrophy Acute Myocardial Infarction 1014-63 Interleukin-1β Induces Left Ventricular Systolic Ignacio M. Seropian, Stefano Toldo, Benjamin W. Van Tassell, Dysfunction Through p38α MAP Kinase Gabriel A. Rabinovich, Antonio Abbate, VCU Pauley Heart Center and VCU School of Pharmacy, Richmond, VA, Laboratorio de Ignacio M. Seropian, Stefano Toldo, Ayobami Omosola, Neeru Goyal, Inmunopatología, Instituto de Biología y Medicina Experimental, Benjamin W. Van Tassell, Abbate Antonio, VCU Pauley Heart Center, Buenos Aires, Argentina Richmond, VA, VCU School of Pharmacy, Richmond, VA Learning Objective: Identify Galectin-1 as an important Learning Objective: to identify p38a MAPK as a target for septic immunomodulator for cartdiac function and remodeling after AMI cardiomyopathy 1015-70 Interleukin-1β Neutralization Ameliorates Post- infarction Cardiac Remodeling In The Mouse

Antonio Abbate, Benjamin W. Van Tassell, Ignacio M. Seropian, Stefano Toldo, Fadi N. Salloum, Amit Varma, Charles A. Dinarello, Virginia Commonwealth University, Pauley Heart Center, Richmond, VA, University of Colorado, Arora, CO Learning Objective: To identify IL-1 blockade as a potential therapeutic strategy in acute myocardial infarction JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A21

1015-72 Suppression Of PDK4 Is Associated With Enhanced 1016 MYOCARDIAL FUNCTION/HEART FAILURE--- Glucose Oxidation And Atrophy In Skeletal BASIC/MOLECULAR--CARDIAC SIGNALING - Muscle Of Animals With Chronic Left Ventricular FIBROSIS Dysfunction Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Aalap D. Chokshi, Raffay Khan, John Morrow, Chad Trent, Steven Marx, Ira Goldberg, P. Christian Schulze, Columbia University Medical Georgia World Congress Center, Hall B5 Center, New York, NY Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Learning Objective: Interpret metabolism in heart failure Cardiac Function and Heart FailureCardiac Function and Heart Inhibition of Cardiac Fibrosis Mediated by Interleukin Family Member ST2 and Mortality in 1016-78 1015-73 Non-Myocyte Proliferation in Hypertrophic Acute Dyspnea Cardiomyopathy Thenral Socrates, Christopher DeFilippi, Tobias Reichlin, Raphael Twerenbold, Tobias Breidhardt, Markus Noveanu, Mihael Potocki, Polakit Teekakirikul, Seda Eminaga, Okan Toka, Libin Wang, Hiroko Robert Christenson, Christian Mueller, University Hospital Basel, Wakimoto, Matthew Nayor, Tetsuo Konno, Cordula M. Wolf, Ronny Basel, Switzerland, University of Maryland, School of Medicine, Alcalai, Joshua Gorham, Joachim P. Schmitt, Brendan Caine, Roger Baltimore, MD R. Markwald, Standley R. Hoffman, Jeffery D. Molkentin, Christine E. Seidman, Jonathan G. Seidman, Department of Genetics Harvard Learning Objective: distinguish the value of various biomarkers for Medical School, Boston, MA, Division of Cardiovascular Medicine the prognosis of mortality in acute heart failure. Brigham and Women’s Hospital, Boston, MA Learning Objective: Describe the cardiac fibrotic responses to Insulin-Like Growth Factor Prevents Diabetes 1015-74 sarcomere gene mutation and the mechanisms by which cardiac Induced Cardiomyopathy Mediated by microRNA-1 fibrosis is inhibited in hypertrophic cardiomyopathy. Yangxin Li, Hanjing Wu, Mang Zhu, Harnath Shelat, Jiangbo Qu, Minjuan Zheng, Jiuhong Yuan, Guoqiang Yuan, Jiaming Xu, Hongwu 1016-79 Progressive Strain Imaging Change and Role of the Wang, Yong-jian Geng, Texas Heart Institute, Houston, TX, Univ of Natriuretic Peptides as Predictors of Left Ventricular Texas Health Science Center, Houston, TX Dysfunction and Fibrosis in Aging Myocardium

Learning Objective: Identify the role of microRNA in cardiomyopathy Diego Bellavia, Jeson S. Sangaralingham, Elise Oehler, Alessandro Cataliotti, Paul McKie, Gerald E. Harders, Margaret M. Redfield, 1015-75 Abnormal Myocardial Energetics in Peroxisome Fletcher A. Miller, Jr., John C. Burnett, Jr, Mayo Clinic, Rochester, MN Proliferator Activated Receptor Gamma Learning Objective: Identify parameter to assess LV dysfunction in Coactivator-1 Beta deficient mice myocardial aging Mohammad N. Jameel, Qiang Xiong, Qinglu Li, Xiaohong Wang, Jianyi Zhang, University of Minnesota, Minneapolis, MN 1016-80 Thrombomodulin Inhibits Cardiomyocyte Apoptosis and Improves Cardiac Contractile Dysfunction in Learning Objective: describe myocardial energetic in PGC1α and Response to Chronic Pressure Overload in Mice PGC1β deficient mice. Yi-Heng Li, Hsing-Chun Chung, Chawn-Yau Luo, Ting-Hsing Chao, 1015-76 Inflammation Induces Transdifferentiation Of Ping-Yen Liu, Guey-Yueh Shi, Hua-Lin Wu, National Cheng Kung Fibroblasts To Myofibroblasts With Pathological University Hospital, Tainan, Taiwan,ROC Remodelling In Endomyocardial Biopsies Of Learning Objective: understand that thrombomodulin has anti- Patients With Hfnef: One Trigger For Diastolic apoptotic effect on cardiomyocyte and improves left ventricular Dysfunction. contractile function Dirk Westermann, Diana Lindner, Mario Kasner, Heinz-Peter Schultheiss, Carsten Tschope, Charite, Campus Benjamin Franklin, 1016-81 Long-Term Therapy with Rosuvastatin Decreases Berlin, Germany Expression of Hypertrophic and Pro-inflammatory Proteins in Left Ventricular Myocardium of Dogs Learning Objective: Understand that inflammation is one key trigger with Moderate Heart Failure for matrix regulation in patients with heart failure and normal EF Sudhish Mishra, Sharad Rastogi, Michael S. Sabbah, Ramesh C. Gupta, Kaitlin Dye, Andrew Cavanagh, Hani N. Sabbah, Henry Ford Hospital, Detroit, MI Learning Objective: Demonstrate the effectiveness of statins in reducing markers of LV hypertrophy and inflammation. A22 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1016-82 Local Autologous Endothelial Progenitor Cell 1065-37 Biventricular Pacing In Patients with Left Ventricular Transplantation (EPC-Tx) in the Chronic Ischemic Assist Devices - Is Left Ventricular Pacing Myocardium Enhances Contractility in the Non- Proarrhythmic?? Ischemic Area: Prevention of Negative Remodeling Andrew D. Choi, Avi Fischer, Anelechi Anyanwu, Sean Pinney, Eric David J. Pedrosa, Dirk Cleppien, Angelica Karpi, Mate Borgulya, Adler, The Mount Sinai Medical Center, New York, NY, Oregon Health Edin Hadzijusufoviç, Holger Jansen, Nico Abegunewardene, Marcus Sciences University, Portland, OR Vosseler, Karl-Friedrich Kreitner, Oliver Kempski, Laura M. Schreiber, Learning Objective: Identify CRT as a possible provocateur of Georg Horstick, Johannes Gutenberg-University Mainz, Second ventricular arrhythmias in patients having undergone Left Ventricular Medical Clinic, Mainz, Germany Assist Device implant Learning Objective: Recognize the global repercussions of a local cell-based therapy in chronic-ischemic myocardium 1065-38 Improved Right Ventricular Myocardial Performance Despite Reduced Longitudinal Deformation after 1016-84 Potent Cardiorenal Antifibrotic Effects of the Rho- Left Ventricular Assist Device Implantation in Kinase Inhibitor Fasudil in Experimental Diabetes Patients with Severe Heart Failure Mellitus. Ravi Rasalingam, Kyle R. Bilhorn, Stephanie N. Johnson, Carl B. Syed Ameenuddin, Elise A. Oehler, Josef Korinek, Jeson Kapadia, Majesh Makan, Nader Moazami, Julio E. Perez, Washington Sangaralingham, Alessandro Cataliotti, Fernando Martin, John A. University in St Louis, St Louis, MO Schirger, Horng H. Chen, Mayo Clinic, Rochester, MN Learning Objective: Evaluate right ventricular function after LVAD Learning Objective: Evaluate role of Rho-Kinase inhibitor in Diabetes implantation mellitus Cardiac Function and Heart Failure 1065-39 Quality of Life Improvements Are Greater in 1016-85 Association of Parvovirus B19 Infection With Destination Therapy than Bridge to Transplant Cardiac Amyloidosis and Myocardial Diseases Patients with a Continuous Flow Left Ventricular Positive for Amyloid Fibrils at Electron Microscopy Assist Device

Maria L. Higuchi, Dirk Lassner, Edimar Bocchi, Charles Mady, Heinz- Juan M. Aranda, Jr., Joseph G. Rogers, Keith D. Aronson, Andrew J. Peter Schultheiss, José AF Ramires, Uwe Kühl, Heart Institute Boyle, Stuart D. Russell, Brooks Edwards, Mark J. Zucker, Charles (InCor) of Clinical Hospital of School of Medicine, Sao Paulo, Brazil, T. Klodell, Jr., Kartik S. Sundareswaran, David J. Farrar, Mark S. Charité - University Medicine, Berlin, Germany Slaughter, HeartMate II Clinical Investigators, University of Florida College of Medicine, Gainesville, FL Learning Objective: Demonstrate Parvovirus B19 in cardiac amyloidosis. 2: identify amyloid fibrils in DCM at EM. 3: Learning Objective: understand the relative quality-of-life benefits demonstrate B19V with different techniques. conferred by continuous flow left ventricular assist devices in patients receiving destination therapy vs. bridge to transplant. 1065 CARDIAC TRANSPLANTATION/ASSIST DEVICES-- GENERAL 1066 DIAGOSIS AND TREATMENT OF HEART FAILURE Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1

1065-35 Impella 2.5 Is Safe and Drastically Reduces 1066-41 Differential Diagnosis of Constrictive Pericarditis Procedure Times in High-Risk Percutaneous from Restrictive Myocardial Disease by Speckle Coronary Interventions when Compared to the Tracking Echocardiography TandemHeart PTVA: Single-center Experience Gabriella Veress, Kye H. Kim, Mitsuru Masaki, Raul E. Espinosa, Jae Huy Trong Nguyen, Rucha Karajgikar, Dheeraj Kaplish, Samin K. K. Oh, Mayo Clinic, Rochester, MN Sharma, Annapoorna S. Kini, Mount Sinai Hosptial, New York, NY Learning Objective: identify a new differential diagnostic tool, Learning Objective: identify the major clinical differences between namely the Speckle Tracking Echocardiography distinguishing the TandemHeart and Imeplla 2.5 percutaneous LVADs for high-risk between Constrictive Pericarditis and Restrictive Myocardial PCI Disease.

1065-36 NT-proBNP Assay may Preclude the Need for Routine Endomyocardial Biopsy to Detect Cardiac Allograft Rejection, but not Early After Transplantation

Carlos T. Aguiar, Maria José Rebocho, Marta Marques, Miguel Abecasis, José Neves, João Figueira, Rosa Gouveia, João Melo, Hospital Santa Cruz, Carnaxide, Portugal Learning Objective: Recognize potential role of BNP for detecting cardiac allograft rejection JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A23

1066-42 Myocardial Strain Reveals Biventricular Impairment 1067-49 Pericardial Effusion Associated With Human in Asymptomatic Arrhythmogenic Right Ventricular Immunodeficiency Virus Infection in the Era of Cardiomyopathy Mutation Carriers Highly Active Antiretroviral Therapy

Kristina H. Haugaa, Sebastian I. Sarvari, Ole-Gunnar Anfinsen, William Strimel, David A. Stewart, II, D. Scott Gantt, Texas A&M Trond P. Leren, Otto A. Smiseth, Jan P. Amlie, Thor Edvardsen, Oslo University Health Science Center College of Medicine, Scott and University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway White Hospital and Clinic, Temple, TX Learning Objective: evaluate asymptomatic ARVC mutation carriers Learning Objective: recognize the effect of antiretrioviral therapy on with strain echocardiography HIV-associated pericardial effusion Cardiac Function and Heart FailureCardiac Function and Heart

1066-43 Natural History of the Danon Disease Phenotype in 1067-50 Predictors of Therapy-Related Congestive Heart a Large Affected Population Failure (CHF) Following Hematopoietic Cell Transplantation (HCT) Luisa Mestroni, Dana Boucek, Jean Jirikowic, Cara Wells, Matthew R.G. Taylor, University of Colorado Denver, Aurora, CO Saro Armenian, Can-Lan Sun, George Mills, Tabitha Shannon, Liton Francisco, F. Lennie Wong, Jean-Bernard Durand, Stephen Forman, Learning Objective: Describe a rare inherited cardiomyopathy Smita Bhatia, City of Hope National Medical Center, Duarte, CA, M.D. Anderson Cancer Center, Houston, TX 1066-44 Hemoconcentration may be a Useful Predictor for Worsening Renal Function During the Treatment of Learning Objective: Idenitfy risk factors for therapy-related CHF Acute Decompensated Heart Failure following hematopoietic cell transplantation

Jeffrey M. Testani, Michael Shumski, Brian D. McCauley, Richard P. 1067-51 Determining the Electrocardiographic Features Shannon, Hospital of the University of Pennsylvania, Philadelphia, PA Specific to Transthyretin Cardiac Amyloid Learning Objective: identify increases in hematocrit during the Jason Dungu, Prayman T. Sattianayagam, Philip N. Hawkins, Lisa J. treatment of acute decompensated heart failure as a possible Anderson, St George’s Hospital, London, United Kingdom, National warning sign for impending worsening renal function. Amyloidosis Centre, London, United Kingdom

1066-45 Restoring Circulating Soluble ACE2 Activity Learning Objective: identify more heart failure patients with possible Following Intensive Medical Therapy Predicts cardiac amyloidosis, prompting further investigation. We propose Improvement in Advanced Decompensated Heart cardiac amyloid is under diagnosed, particularly in the afrocaribbean Failure population.

Zhili Shao, Kevin L. Shrestha, Allen G. Borowski, Slava Epelman, Wai Hong Wilson Tang, Cleveland Clinic, Cleveland, OH 1068 CRT OPTIMIZATION AND OUTCOMES Learning Objective: Determine clinical, echocardiographic and Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. hemodynamic determinants and prognostic utility of serial sACE2 Georgia World Congress Center, Hall B5 activity levels in setting of ADHF and intensive medical therapy Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1067 CARDIOMYOPATHIES 1068-52 Impact of Cardiac Resynchronization Therapy on Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Diastolic Function: a Meta-analysis Georgia World Congress Center, Hall B5 Sanjay Kumar, Amit Nautiyal, Saurabh Kaushik, Jason M. Lazar, Presentation Hour: 3:30 p.m. - 4:30 p.m. Richard A. Grimm, Cleveland Clinic Foundation, Cleveland, OH CME/CE Hours: 1 Learning Objective: Understand impact of CRT on diastolic function 1067-47 Obesity Cardiomyopathy: A New Concept of Secondary Cardiomyopathy with Unique 1068-53 Comprehensive Device Interrogation and Ultrastructural Features Pacemaker Optimization at Rest and Stress Improves Functional Class in Non Responders to Tsunenori Saito, Kuniya Asai, Hiroshi Takahashi, Hidenori Cardiac Resynchronization Treatment Komiyama, Koji Kato, Eisei Yamamoto, Hitoshi Takano, Toshihiko Ohara, Yuh Fukuda, Kyoichi Mizuno, Nippon Medical School Tasneem Z. Naqvi, Nima Taha, Rupesh Ranjan, Jing Zhang, Samuel Hospital, Tokyo, Japan Daneshvar, Elizabeth Guillen, University of Southern California, Los Angeles, CA Learning Objective: clarify the functional and structural changes of myocardium with dilated cardiomyopathy and obesity Learning Objective: Learn pacemaker programming and echo Doppler during pacemaker optimization 1067-48 Myocardial Fibrosis Attenuates the Effect Of Cibenzoline on Left Ventricular Diastolic Function in Patients with Hypertrophic Cardiomyopathy

Makoto Saito, Yasuhiro Sasaki, Toyofumi Yoshii, Go Hiasa, Takumi Sumimoto, Kazuhisa Nishimura, Katsuji Inoue, Hideki Okayama, Mareomi Hamada, Jitsuo Higaki, Kitaishikai hospital, Ozu, Japan A24 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1068-55 Role of End-Systolic Pressure-Volume Relationship 1069 MYOCARDIAL REPAIR-STEM CELLS AND OTHER in the Identification of Responders to Cardiac MECHANISMS Resynchronization Therapy Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Quirino Ciampi, Lorenza Pratali, Rodolfo Citro, Michele Della Porta, Georgia World Congress Center, Hall B5 Bruno Villari, Eugenio Picano, Rosa Sicari, Fatebenefratelli Hospital, Benevento, Italy, CNR, Institute of Clinical Physiology, Pisa, Italy Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 Learning Objective: to evaluate a new method to identy responders to cardiac resynchronization therapy 1069-61 Efficacy of Intramyocardial Injections of Autologous Bone Marrow Mononuclear Stem Cells in Patients Successful Restoration of Heart Rate 1068-56 with Ischemic Heart Failure: Long-Term Results Responsiveness to Exercise Using Cardiac Resynchronization Therapy Delays Anaerobic Evgeny Pokushalov, Alexander Romanov, Sregey Artemenko, Threshold in Patients with Advanced Heart Failure Alexander Cherniavskiy, Petr Larionov, Igor Terehov, Olga Poveschenko, Elena Kliver, Alexander Karaskov, State Research Daniel Sims, Andrea Mignatti, Paolo C. Colombo, Pierantonio Institute of Circulation Pathology, Novosibirsk, Russian Federation Laveneziana, Nir Uriel, Frederick A. Ehlert, Ulrich P. Jorde, Columbia University Medical Center, New York, NY, New York University School Learning Objective: Intramyocardial injection of autologous bone of Medicine, New York, NY marrow mononuclear cells in ischemic heart failure patients is a safe procedure that improves clinical symptoms and has beneficial Learning Objective: To describe the efffects of rate adaptive pacing effect on LV function. on exercise capacity in patients with advanced heart failure and severe chronotropic incompetence. Cardiac Function and Heart Failure 1069-62 Stromal Cell-Derived Factor-1, Granulocyte Colony Stimulating Factor, Fibroblast, Vascular Endothelial Detection of Regional Low Myocardial 1068-57 and Hepatocyte Growth Factors Are Increased in Perfusion Helps Predict a Response to Cardiac Hypoxia/Anoxia Conditioned Bone Marrow-Derived Resynchronization Therapy in Patients With Non- Stem Cell Medium ischemic Cardiomyopathy:Find Index by Nuclear Imaging for Dyssynchrony (FIND) Study Sharad Rastogi, Michael S. Sabbah, Hani N. Sabbah, Henry Ford Hospital, Detroit, MI Takehiko Keida, Itsuro Morishima, Taketsugu Tsuchiya, Kouichi Sagara, Kaoru Okishige, Kenta Kumagai, Yoshiaki Mibiki, Tamon Learning Objective: Demonstrate that stem cells can elaborate factors Yamanaka, Yukihiko Yoshida, Kentaro Nakamura, Akira Yamamoto, that are likely to be responsible for the beneficial effects on LV function. Mitsuaki Takami, Edogawa Hospital, Tokyo, Japan Exercise Training Reverses Dysfunction of Early Learning Objective: Predict Response to Cardiac Resynchronization 1069-63 Endothelial Progenitor Cells in Patients with Chronic Therapy Heart Failure.

1068-58 CRT In Mild Heart Failure: Response In Relation Emeline M. Van Craenenbroeck, Paul Beckers, Nadine Possemiers, To Heart Failure Etiology? 24 Month Results From Kurt Wuyts, Vicky Hoymans, Geert Frederix, Christiaan Vrints, The Resynchronisation Reverses Remodelling In Viviane Conraads, Antwerp University Hospital, Edegem, Belgium Systolic Left Ventricular Dysfunction (reverse) Study Learning Objective: identify one of the mechanisms for the Cecilia Linde, William T. Abraham, Michael R. Gold, Martin St. John beneficial effects of exercise training on endothelial function Sutton, Stefano Ghio, Jean Claude Daubert, University Hospital, Karolinska, Stockholm, Sweden 1069-64 Bone Marrow EPC Function Relative to Time of Collection after Acute Myocardial Infarction Learning Objective: To demonstrate that the effects of CRT in less severe heart failure (HF) patients is related to HF etiology Mark S. Segal, Maria Grant, Doris Taylor, Chris Cogel, Lemuel Moyé, Carl Pepine, University of Florida, Gainesville, FL, University of 1068-59 Predicting Survival Among Patients Undergoing Minnesota, Minneapolis, MN Cardiac Resynchronization Using a Simple Scoring Learning Objective: Describe the level of nitric oxide and its source System in bone marrow cells after different times after an MI. Evan C. Adelstein, Sanjoy Bhattacharya, Samir Saba, University of Pittsburgh, Pittsburgh, PA 1069-65 Utility of Doppler Myocardial Imaging, Cardiac Biomarkers and Clonal Immunoglobulin Genes Learning Objective: Identify baseline clinical variables that predict to Assess Left Ventricular Performance and survival after cardiac resynchronization therapy. Stratify Risk Following Peripheral Blood Stem Cell Transplantation in Patients with Systemic Light Chain Amyloidosis (AL).

Diego Bellavia, Roshini S. Abraham, Patricia A. Pellikka, Angela Dispenzieri, John C. Burnett, Jr., Ghormallah B. Al-Zahrani, Morie A. Gertz, Fletcher A. Miller, Jr., Theodore P. Abraham, Mayo Clinic, Rochester, MN Learning Objective: Understand high sensitivity of strain and genetics in risk stratification JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A25

1069-67 Polyunsaturated Fatty Acids and Omega-3 as 1070-73 Increased Circulating Matrix Gla Protein In Heart Predictors of Mortality in Depressed Heart Failure Failure-association With Functional, Hemodynamic (HF) Patients And Neurohormonal Disease Severity

Mona Fiuzat, Wei Jiang, Harry Oken, Linda Shaw, Maragatha Thor Ueland, Christen P. Dahl, Lars Gullestad, Pal Aukrust, Sven Kuchibhatla, Michael Cuffe, Shelby Ladd, Ranga Krishnan, Aakhus, Kaspar Broch, Cees Vermeer, Leon J. Schurgers, Oslo Christopher O’Connor, Duke University Medical Center, Durham, NC, University Hospital, Oslo, Norway, Maastricht University, Maastricht, Duke Clinical Research Institute, Durham, NC The Netherlands Learning Objective: Describe the potential influence of Omega-3 Learning Objective: Describe matrix gla protein in the context of Cardiac Function and Heart FailureCardiac Function and Heart fatty acids on survival heart failure development

1069-68 Patients With Underlying Right Bundle Branch Block 1070-74 Novel Biomarkers Associated with Left Ventricular Exhibit Worsened Longitudinal Myocardial Strain Hypertrophy With Biventricular Pacing As Compared To Those Palaniappan Manickam, Vikas Veeranna, Ankit Rathod, Pawan Hari, With Left Bundle Branch Block Sandip Zalawadiya, Apurva Badheka, Sony Jacob, Luis Afonso, Sabe De, Zoran Popovic, David Verhaert, Thomas Dresing, Randall Wayne State University, Detroit, MI Starling, Wai Hong Tang, Bruce Wilkoff, James D. Thomas, Richard Learning Objective: to identify the strong positive association of A. Grimm, Cleveland Clinic Foundation, Cleveland, OH intercellular adhesion molecule and soluble tumor necrosis factor Learning Objective: To demonstrate differences in longitudinal strain with left ventricular hypertrophy. for LBBB versus RBBB 1070-75 Plasma Nor-Epinephrine Levels and Mortality in Patients with Advanced Chronic Systolic Heart 1070 MYOCARDIAL FUNCTION/HEART FAILURE--- Failure: Insights from the BEST Study BASIC/MOLECULAR Mustafa I. Ahmed, Marjan Mujib, Wilbert S. Aronow, Gerasimos Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Filippatos, Prakash Deedwania, Ali Ahmed, University of Alabama at Georgia World Congress Center, Hall B5 Birmingham, Birmingham, AL, VA Medical Center, Birmingham, AL Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: Understand associations between plasma CME/CE Hours: 1 norepineprhrine and outcomes in patients with advanced chronic systolic heart failure 1070-69 Hydralazine-Nitroglycerin Combination Reduces Diastolic Calcium Leak In Adult Cardiomyocytes 1070-76 Left Ventricular Torsion Early after Myocardial From Nitric Oxide Synthase-1-Deficient Mice Infarction: Its Determinants and Ability to Predict Left Ventricular Remodeling Raul A. Dulce, Daniel R. Gonzalez, Adriana V. Treuer, Joshua M. Hare, Interdisciplinary Stem Cell Institute, Miami, FL Gaetano Nucifora, Matteo Bertini, Nina Ajmone Marsan, Victoria Delgado, Arnold CT Ng, Eduard R. Holman, Hans-Mark J. Siebelink, Learning Objective: Interpret and distinguish the effects of Jacob M. Van Werkhoven, Ernst E. Van Der Wall, Martin J. Schalij, hydralazine-nitroglycerin combination in a model of elevated Jeroen J. Bax, Leiden University Medical Center, Leiden, The sarcoplasmic reticulum calcium leakage Netherlands

1070-70 Novel Heart Failure Markers in Systolic, Diastolic Learning Objective: evaluate LV torsion post-AMI and Other Heart Failure

Raoul Stahrenberg, Frank Edelmann, Meinhard Mende, Jan Kunde, 1071 HEART FAILURE WITH PRESERVED EJECTION Jana A. Papassotiriou, Gerd Hasenfuss, Burkert Pieske, Rolf FRACTION Wachter, University Hospital Goettingen, Goettingen, Germany, Germany Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Learning Objective: describe the diagnostic value of novel biomarkers in diastolic heart failure. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1070-72 Diastolic Function Along the Diabetic Spectrum 1071-78 Preclinical Diastolic Dysfunction: The Kidney-Heart Raoul Stahrenberg, Meinhard Mende, Frank Edelmann, Lisa Connection Schoenbrunn, Gerd Hasenfuss, Burkert Pieske, Rolf Wachter, University Hospital Goettingen, Goettingen, Germany, Germany Horng H. Chen, Sherry Benike, Lynn Harstad, Lisa Costello- Boerrigter, John A. Schirger, Robert D. Simari, Margaret M. Redfield, Learning Objective: describe the association between glucose John C. Burnett, Mayo Clinic, Rochester, MN metabolism and diastolic function across a wide spectrum of glucose metabolism states. Learning Objective: To dtermine the renal function in LV dysfunction A26 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1071-79 Clinical and Prognostic Value of Galectin-3, a 1120 HEMODYNAMICS AND QUALITY OF LIFE IN Novel Fibrosis-Associated Biomarker. Relation with HEART FAILURE Clinical and Biochemical Correlates of Heart Failure. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Rudolf A. De Boer, Dirk Lok, Johannes L. Hillege, Adriaan A. Voors, Georgia World Congress Center, Hall B5 Wiek H. van Gilst, Tiny Jaarsma, Dirk J. van Veldhuisen, University Medical Center Groningen, Groningen, The Netherlands Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Learning Objective: Evaluate the role of a novel biomarker in heart failure 1120-35 The Correlation of B-Type Natriuretic Peptide to Pulmonary Capillary Wedge Pressure is Markedly Ultrafiltration in Heart Failure Patients with 1071-81 Blunted in Overweight and Obese Patients Preserved Systolic Function Jamil B. Dihu, William G. Cotts, Gudaye Tasissa, Micah J. Eimer, Eugene S. Chung, Santosh Menon, Cheryl Bartone, Nanandakishore University of Chicago Pritzker School of Medicine, Chicago, IL, Akula, Jackie Wagner, The Christ Hospital, Cincinnati, OH, The Ohio Northwestern University Feinberg School of Medicine, Chicago, IL Heart and Vascular Center, Cincinnati, OH Learning Objective: Demonstrate an understanding of the Learning Objective: evaluate effect of ultrafiltration on HF patients relationship between BNP levels and PCWP in lean, overweight, and with preserved EF obese patients. Clinical Characteristics, Hemodynamics, and 1071-82 The Kansas City Cardiomyopathy Questionnaire Outcomes of Heart Failure with Preserved Ejection 1120-36 Predicts Long-Term Mortality and Heart Failure

Cardiac Function and Heart Failure Fraction and Normal B-type Natriuretic Peptide Rehospitalization in African American Patients with Level Acute Decompensated Heart Failure Venkatesh Y. Anjan, Sanjiv J. Shah, Northwestern University Feinberg sirikarn napan, M. Tarek Alahdab, Ibrahim N. Mansour, Howard School of Medicine, Chicago, IL University, Washington D.C., DC, John H. Stroger, Jr. Hospital of Learning Objective: describe the clinical characteristics of patients Cook County, Chicago, IL with HFpEF and normal BNP levels Learning Objective: Evaluate the prognostic value of the Kansas City Cardiomyopathy Questionnaire in African-American population 1071-84 Heart Failure with Recovered Ejection Fraction: A Distinct Entity within Heart Failure and Preserved 1120-37 Laboratory Evidence of Congestive Hepatopathy Ejection Fraction Predicts Improvement in Renal Function During the Lynn Punnoose, Parakash Pratibhu, Michael M. Givertz, Eldrin F. Treatment of Acute Decompensated Heart Failure Lewis, Lynne W. Stevenson, Akshay Desai, Brigham and Women’s Jeffrey M. Testani, Michael Shumski, Brian D. McCauley, Richard P. Hospital, Boston, MA Shannon, Hospital of the University of Pennsylvania, Philadelphia, Learning Objective: identify the distinct clinical and demographic PA features of heart failure patients with recovered EF, compared to Learning Objective: identify patients with laboratory evidence of those with stable preserved EF. hepatic congestion as a population that may also have venous congestion induced renal dysfunction and improve their renal 1071-85 Hyponatremia, Natriuretic Peptides and Outcomes function with diuresis. in Acutely Destabilized Heart Failure

Asim A. Mohammed, Roland RJ van Kimmenade, Mark Richards, 1120-38 Can Echocardiographic Evaluation of Antoni Bayes-Genis, Yigal Pinto, Stephanie A. Moore, James L. Cardiopulmonary Hemodynamics Replace Right Januzzi, Jr, Massachusetts General Hospital, Boston, MA Heart Catheterization in End-Stage Heart Failure Patients Awaiting Transplantation? Learning Objective: understand the long-term prognostic utility of hyponatremia and its association with amino-terminal pro-B type Suman Kuppahally, Edward M. Gilbert, Sheldon E. Litwin, Stephen natriuretic peptide in acutely decompensated heart failure patients. M. Ishihara, Renee Neuharth, Andrew D. Michaels, Anwar Tandar, Feras Bader, University of Utah, Salt Lake City, UT Learning Objective: Identify the utility of echocardiography in assessing patients with end-stage cardiomyopathy awaiting transplantation

1120-39 Single Beat Estimation of the Left Ventricular End- diastolic Pressure Volume Relationship in Humans With and Without Heart Failure

Rodrigo V. Wainstein, Zion Sasson, Joan Persaud, Susanna Mak, Division of Cardiology, Mount Sinai Hospital, Toronto, ON, Canada Learning Objective: Identify that the single beat method can be used to assess EDPVR and that increases in heart rate exert greater effect on LV compliance of heart failure patients than in normal LV patients JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A27

1121 COMORBIDITIES AND CARDIOMYOPATHIES 1122 GENETICS AND CARDIOMYOPATHIES Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1121-41 Deleterious Impact of Mild Anemia on 1122-47 Can CMR Characterize the Etiology of the Septal

Survival of Young Patients with Idiopathic Bounce in Patients with Constrictive Pericarditis? FailureCardiac Function and Heart Dilated Cardiomyopathy. Data from Trieste George O. Angheloiu, Geetha Rayarao, Mark Doyle, Saundra Grant, Cardiomyopathies Registry Robert WW Biederman, DuBois Regional Medical Center, DuBois, PA Aneta Aleksova, Giulia Barbati, Marco Merlo, Davide Stolfo, Cosimo To learn the etiology of the ‘septal bounce’ in proven constrictive Carriere, Andrea Di Lenarda, Gianfranco Sinagra, Cardiovascular pericarditis via CMR and dynamic Quiver Plot analysis Department, Trieste, Italy, Cardiovascular Center, Azienda per i Servizi Sanitari (A.S.S.) N°1 of Trieste, Trieste, Italy 1122-48 Influence of Genetic Factors on Left Ventricular Learning Objective: understand the importance of mild anemia on Structure and Function in Friedreich’s Ataxia survival of young patients with heart failure affected by Idioopathic Dilated Cardiomyopathy. Sarah Lagedrost, Ted Plappert, Martin St John Sutton, David Lynch, CHOP, Philadelphia, PA, University of Pennsylvania, Philadelphia, PA 1121-42 Predictors of Constrictive Pericarditis Following Learning Objective: Evaluate the cardiomyopathy of Friedreich ataxia Pericardiocentesis for Significant Pericardial Effusion 1122-49 Prognostic Stratification of Biopsy-Proven Active Kye Hun Kim, Lawrence Sinak, Gellian Nestbitt, Raul E Espinosa, Myocarditis Presenting with Heart Failure: Are there A. Jamil Tajik, Jae K Oh, Mayo Clinic, Rochester, MN, Chonnam Predictors of Long Term Prognosis? National University Hospital, Gwangju, South Korea Marco Merlo, Gastone Sabbadini, Bruno Pinamonti, Gherardo Learning Objective: know the predictive findings of constrictive Finocchiaro, Alessandra Buiatti, Giulia Barbati, Andrea Di Lenarda, pericarditis after pericardiocentesis Gianfranco Sinagra, Ospedali Riuniti and University, Trieste, Italy Learning Objective: Analyze the natural history of acute myocarditys 1121-43 Transient Left Ventricular Ballooning Syndrome: A presenting with heart failure and demonstrate the prognostic rolo Large Prospective Series of improvement of left ventricular ejection fraction on medical treatment Peter M. Kayaert, Bert Ferdinande, Peter Sinnaeve, Christophe Dubois, Tom Adriaenssens, Mark Coosemans, Walter Desmet, Universitair Ziekenhuis Leuven, Leuven, Belgium 1122-50 The +49ag Polymorphism in Exon 1 of the Cytotoxic T-lymphocyte-associated Protein 4 Is Associated Learning Objective: identify patients with transient left ventricular with Dilated Cardiomyopathy ballooning syndrome and estimate outcome Volker Ruppert, Thomas Meyer, Clarissa Struwe, Jana Petersen, 1121-44 Prognostic Value of Left Ventricular Dimension Andreas Perrot, Maximilian G. Posch, Cemil Özcelik, Anette Richter, Beyond Peak Oxygen Consumption in Systolic Heart Bernhard Maisch, Sabine Pankuweit, German Competence Network Failure Patients of Heart Failure, Philipps-University, Marburg, Germany, Max- Delbrück Center for Molecular Medicine, Berlin, Germany Eileen M. Hsich, Eiran Z. Gorodeski, David O. Taylor, Randall C. Learning Objective: describe new polymorhisms associated with Starling, Penny Houghtaling, Michael S. Lauer, Cleveland Clinic, DCM Cleveland, OH, NHLBI, NIH, Bethesda, MD

Learning Objective: To identify left ventricular end-systolic and end- 1122-51 Angiotensin-converting Enzyme Insertion/Deletion diastolic dimensionas a predictor for mortality in ambulatory heart Polymorphisms Contributes to Favorable Clinical failure patients with systolic dysfunction Courses of Hypertrophic Cardiomyopathy Caused by MYBPC3 Gene Mutations 1121-45 Predictive Factors For Survival in Patients with Diastolic Dysfunction of Varying Severity Who Do Akira Funada, Noboru Fujino, Eiichi Masuta, Hidekazu Ino, Masakazu Not Have Systolic Dysfunction or Symptoms of Yamagishi, Kanazawa University Hospital, Division of Intesive Care Heart Failure Unit, Kanazawa, Japan, Kanazawa University, Division of Cardiology, Kanazawa, Japan Mazda Biria, Subba Reddy Vanga, Dhanunjaya Lakkireddy, Patricia Learning Objective: discribe that angiotensin-converting enzyme Howard, James L. Vacek, University of Kansas Hospital, Kansas insertion/deletion polymorphisms contributes to favorable clinical City, KS, University of Kansas Medical Center, Kansas City, KS courses of hypertrophic cardiomyopathy caused by MYBPC3 gene Learning Objective: identify predictive factors for survival in patients mutations with diastolic dysfunction without systolic dysfunction or symptoms of HF A28 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1123 HOSPITALIZATION AND MORTALITY IN HEART 1123-58 Non-selective Beta-blockers Decrease Thrombotic FAILURE Events in Patients with Heart Failure Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Olav R. De Peuter, Patrick C. Souverein, Olaf H. Klungel, Gregory Y. Lip, Harry R. Büller, Anthonius De Boer, Pieter W. Kamphuisen, Georgia World Congress Center, Hall B5 Academic Medical Center, Amsterdam, The Netherlands Presentation Hour: 9:30 a.m. - 10:30 a.m. Learning Objective: identify the possible antithrombotic effects of CME/CE Hours: 1 non-selective beta-blockers Risk Factors for Recurrent Heart Failure Events in the 1123-52 Atrial Fibrillation in Heart Failure is associated with Multicenter Automatic Defibrillator Trial II (MADIT-II) 1123-59 an Increased Risk of Death only in Patients with Edward Sze, Arthur J. Moss, Scott McNitt, Wojciech Zareba, Ilan Ischemic Heart Disease Goldenberg, University of Rochester, School of Medicine and Jakob Raunso, Ole D. Pedersen, Helena Dominguez, Morten L. Dentistry, Rochester, NY Hansen, Jacob E. Moller, Jesper Kjaergaard, Christian Hassager, Learning Objective: Identify risk factors for recurrent heart failure Christian Torp-Pedersen, Lars Køber, Gentofte Hospital, Hellerup, events in patients with left ventricular dysfunction. Denmark Learning Objective: demonstrate that the prognostic impact of Serial Studies of Seattle Heart Failure Model 1123-53 atrial fibrillation in a large heart failure population depends on an Improve the Prediction of Pump Failure Death, underlying ischemic etiology. not Sudden Death, in Stable Outpatients With Mild to Moderate Chronic Heart Failure: A 10-Year Cardiac Function and Heart Failure Prospective Study 1124 -RISK STRATIFICATION IN HEART FAILURE

Takahisa Yamada, Yuji Okuyama, Takashi Morita, Yoshio Furukawa, Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Koji Tanaka, Yusuke Iwasaki, Taku Yasui, Michihiro Ueda, Takeshi Georgia World Congress Center, Hall B5 Okada, Masato Kawasaki, Yuki Kuramoto, Wayne C. Levy, Masatake Presentation Hour: 9:30 a.m. - 10:30 a.m. Fukunami, Osaka General Medical Center, Osaka, Japan CME/CE Hours: 1 Learning Objective: learn the prognostic significane of serial evaluation of Seattle Heart Failure Model 1124-61 Determinants of Morbidity and Mortality in Chronic Heart Failure (CHF) with Systolic Dysfunction: 1123-55 Non invasive Lung Impedance Monitoring In The Results of the HF-ACTION Predictive Model Outpatient Clinic Facilitates The Prediction Of Hospitalization Of Patients With Decompensated Christopher M. O’Connor, Daniel Wojdyla, Eric Leifer, Stephen Ellis, Heart Failure And Enables Early Therapy To Prevent Kerry Lee, Robert Clare, Ileana Pina, Steven Keteyian, Dalane Kitzman, William Kraus, David Rendall, Lawton Cooper, David Hospitalizations Whellan, Duke Clinical Research Institute, Durham, NC, NIH/NHLBI, Michael Shochat, Avraham Shotan, David Blondhaim, Mark Bethesda, MD Kazatsker, Vladimir Gurovich, Aya Asif, Lubov Vasilenko, Elena Learning Objective: To describe predictive variables from a large Neiman, Aaron Frimerman, Paul Rabinovich, Simcha Meisel, Hillel clinical trial evaluating exercise training in HF Yaffe Heart Institute, Hadera, Israel, Sorasky Medical Center, Tel Aviv, Israel 1124-62 Novel Utilization of the Seattle Heart Failure Model Learning Objective: To demonstrate that using surface thoracic to Optimize Goals of Therapy in Patients Admitted impedance monitoring for chronic heart failure patients reliably with Acutely Decompensated Heart Failure. predicts decompensation two weeks before and early impedance guided treatment prevent readmi Samira Bahrainy, Eliabeth Maas, Abhijeet Singh, Hal A. Skopicki, Stony Brook University Medical Center, Stony Brook, NY 1123-56 Factors That Precipitate Hospitalizations for Learning Objective: Identify the important clinical variables needed Heart Failure With Preserved Ejection Fraction - to optimize management in patients with ADHF Characteristics and Impact on Post-Discharge Outcome Combined Predictive Value of Depression and Dan Rusinaru, Otilia Buiciuc, Franck Lévy, Marcel Peltier, Christophe 1124-63 B-type Natriuretic Peptide for Mortality in Heart Tribouilloy, University Hospital Amiens, France, Amiens, France Failure Patients: The Cardiovascular Health Study Learning Objective: Understand the importance of factors that precipitate hospital admissions in heart failure with preserved Willem J. Kop, Krista C. van den Broek, Christopher R. DeFilippi, ejection fraction Robert H. Christenson, Stephen L. Seliger, John S. Gottdiener, University of Maryland, Department of Medicine (Cardiology), Baltimore, MD, Tilburg University, Ctr of Research on Psychology in 1123-57 Hydralazine and Isosorbide Dinitrate Improve Mortality in Blacks and Non-Blacks With Diastolic Somatic diseases, Tilburg, The Netherlands Heart Failure Learning Objective: Identify depression in conjunction with biomarkers as additive risk factors for mortality in heart failure Jeremy A. Mazurek, Ronald Zolty, Montefiore Medical Center, Albert patients Einstein College of Medicine, Bronx, NY Learning Objective: identify a treatment that may decrease mortality in both Black and Non-Black patients with diastolic heart failure. JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A29

1124-64 Relation Between Myocardial Viability, Clinical 1125-70 History Of Heart Failure Hospitalizations And Presentation, and Risk Stratification in Patients Benefit From Home-based Nurse Care In Chronic with Ischemic Cardiomyopathy on Optimal Medical Heart Failure Therapy. A Report from the STICH Trial deddo moertl, Raisa Hutuleac, Andreas Gleiss, Alexandra Hammer, Federico M. Asch, Thomas A. Holly, Lilin She, Gerald Maurer, Asima Delalic, Rudolf Berger, Medical University of Vienna, Vienna, Matthias Siepe, Eric J. Velazquez, Adam Ostrzycki, Beata Sredniawa, Austria Tiziana Attisano, Jonathan Howlett, Robert O. Bonow, Julio A. Learning Objective: identify markers that predict benefit from home- Panza, Washington Hospital Center, Washington, DC, Northwestern based nurse care in chronic heart failure University Feinberg School of Medicine, Chicago, IL FailureCardiac Function and Heart Learning Objective: describe the lack of impact of myocardial 1125-72 New Model Of Home-based Tele-ecg-monitored viability in the clinical presenation of patients with ischemic Cardiac Rehabilitation In Patients With Heart cardiomyopathy. Failure: Effectiveness, Quality Of Life, Safety, And Adherence 1124-65 Variations in the Cardiovascular Effect of Uric Acid by Serum Insulin Levels: Mechanistic Insights from Ewa Piotrowicz, Rafał Baranowski, Maria Bili ska, Monika Epidemiological Observations Stepnowska, Małgorzata Piotrowska, Tomasz Zieli ski, Ryszard Piotrowicz, Institute of Cardiology, Warsaw, Ali Ahmed, UAB and VAMC, Birmingham, AL Learning Objective: demonstrated that in heart failure patients Learning Objective: To understand that uric acid may not have any home-tele-cardiac rehabilitation is as effective and improves the intrinsic effect on cardiovascular events HRQoL as standard cardiac rehabilitation on cycle ergometers

1124-67 Change in ST2 Level: Refining Risk Stratification in 1125-73 Discharge Education Improves Knowledge And the Dyspnea Patient Outcomes In Heart Failure Patients

Christopher R. DeFilippi, Robert Christenson, Keyur Shah, Sue Naga V. Kommuri, Arun Damodaran, Todd M. Koelling, DMC-Sinai- Henderson, Willem Kop, University of Maryland, Baltimore, MD Grace Hospital, DETROIT, MI, University of Michigan Hospital, Ann Arbor, MI Learning Objective: Determine for patients with acute dyspnea presentations the frequency of change in ST2 levels at follow-up Learning Objective: Nurse educator delivered discharge education and the significance of absence of change. improves knowledge and clinical outcomes in heartfailure patients

1124-68 Serum Albumin Concentration and Heart Failure 1125-74 Improved Algorithm to Detect Fluid Accumulation Risk via Intrathoracic Impedance Monitoring in Heart Failure Patients with Implantable Devices Deepa Mangalat, Emory University, Atlanta, GA Douglas A. Hettrick, Shantanu Sarkar, Jodi Koehler, Tyson Rogers, Learning Objective: evaluate serum albumin as a time-dependent Cheuk-Man Yu, William Abraham, Roy Small, W.H. Wilson Tang, risk for heart failure. Further studies are needed to delineate the Medtronic, Inc., Minneapolis, MN, Cleveland Clinic, Cleveland, OH screening potential of serum albumin for high-risk persons and for clinical practice. Learning Objective: Identify clinically usefull tools to monitor heart failure patients. 1125 HEART FAILURE DISEASE MANAGEMENT 1125-75 Effects of the Oral Direct Renin Inhibitor Aliskiren Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. on Plasma BNP concentration in Patients Georgia World Congress Center, Hall B5 with Symptomatic Heart Failure According to Presentation Hour: 9:30 a.m. - 10:30 a.m. Background Dose of ACE inhibitor CME/CE Hours: 1 John JV McMurray, Claudio Gimpelewicz, Roberto Latini, Aldo P. Maggioni, Bertram Pitt, Scott D. Solomon, Anil Verma, Beverly A. 1125-69 Impedance-guided Treatment Prevents Acute Heart Smith, Deborah L. Keefe, Margaret F. Prescott, James D. Lewsey, Failure in the Course of Acute Myocardial Infarction University of Glasgow, Glasgow, United Kingdom and reduced long-term mortality Learning Objective: undestand possible actions of renin inhibitors in Michael Shochat, Avraham Shotan, David Blondhaim, Mark heart failure Kazatsker, Vladimir Gurovich, Aya Asif, Lubov Vasilenko, Elena Neiman, Morris Mosseri, Aaron Frimerman, Paul Rabinovich, Simcha 1125-76 Short-term Waiting List Survival Without Support By Meisel, Hillel Yaffe Heart Institute, Hadera, Israel, Sorasky Medical A Ventricular Assist Device Center, Tel Aviv, Israel Mark J. Russo, Jonathan Yang, Alexander Iribarne, Kimberly N. Learning Objective: To know that using surface thoracic impedance Hong, Hiroo Takayama, Ryan R. Davies, MD, Allan S. Stewart, monitoring in course of acute myocardial infarction for beginning Jonathan M. Chen, Mathew Williams, Michael Argenziano, Yoshifumi treatment for prevention acute heart failure development improve Naka, Columbia University Medical Center, New York, NY hospital stay, reduce Learning Objective: Demonstrate understanding of patient risk factors at the time of listing that predict 30-day survival without the need for a ventricular assist device . A30 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1126 NONPHARMACOLOGIC THERAPIES FOR HEART 1126-82 Adaptive Servoventilation Treatment of Complex FAILURE Sleep Apnea in Heart Failure Patients Improves Subjective and Objective Cardiac Functional Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Parameters Georgia World Congress Center, Hall B5 Thomas Bitter, Roman Lehmann, Christian Prinz, Christoph Langer, Presentation Hour: 9:30 a.m. - 10:30 a.m. Dieter Horstkotte, Olaf Oldenburg, Department of Cardiology, Heart CME/CE Hours: 1 and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany Improvement of Longitudinal Left Ventricular Strain 1126-78 Learning Objective: identify complex sleep apnea and learn about is Associated with Left Atrial Strain Enhancement treatment effects of adaptive servoventilation in heart failure After Pulmonary-vein Isolation for Atrial Fibrillation patients with complex sleep apnea Jun Koyama, Hirohiko Motoki, Kazunori Aizawa, Megumi Koshikawa, Hiroki Kasai, Atsushi Izawa, Takeshi Tomita, Yusuke Miyashita, 1126-84 Central Sleep Apnea Events are Terminated By Setsuo Kumazaki, Uichi Ikeda, Shinshu University Graduate School Phrenic Nerve Stimulation of Medicine, Matsumoto, Japan Piotr Ponikowski, Shi-Jiang Zhang, Thomasz Witkowski, Ayesha Learning Objective: learn relation between left atrial and left Hasan, Rami Khayat, Bradley Bart, Dariusz Jagielski, Xilong Zhang, ventricular function after pulmonary-vein isolation for atrial Center for Heart Disease - Clinical Military Hospital, Wroclaw, fibrillation. Poland, Jiangsu Provincial People’s Hospital, Nanjing, People’s Republic of China Atrial Lead Implantation is Associated With 1126-79 Learning Objective: Understand that stimulation of the phrenic Cardiac Function and Heart Failure Conversion to Sinus Rhythm and Maintenance nerve during central apnea event may halt or avert the apnea. of Sinus Rhythm in Patients With Long-Standing Atrial Fibrillation Undergoing Atrioventricular Node 1126-85 Cardiac Resynchronization Differentially Impacts Ablation and Biventricular Pacemaker Implantation Survival in Heart Failure Patients Based Upon Raul Alexis Torres Heisecke, Vassilis Dimas, Andrew W. Owens, Jose Baseline Renal Function A. Joglar, Owen A. Obel, University of Texas Southwestern Medical Evan C. Adelstein, Alaa Shalaby, Samir Saba, University of Center Dallas, Dallas, TX Pittsburgh, Pittsburgh, PA, Pittsburgh VA Health System, Pittsburgh, Learning Objective: Evaluate patients for atrial lead implantation PA while undergoing AVN ablation+BiV implantation for long-standing Learning Objective: Describe the impact of renal insufficiency upon atrial fibrillation as they may be more likely to convert to and survival among patients undergoing cardiac resynchronization maintain sinus rhythm therapy .

1126-80 Pulmonary Vein Isolation For Persistent Atrial Fibrillation In Patients With Severe Heart Failure 1175 GENETICS AND CARDIOMYOPATHIES II

Michael R. MacDonald, John McMurray, Tracey Steedman, Morag Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Shaw, Henry Dargie, Nathaniel Hawkins, Martin Denvir, Sai Bhagra, Georgia World Congress Center, Hall B5 John Payne, Derek Connelly, Mark Petrie, Golden Jubilee National Presentation Hour: 3:30 p.m. - 4:30 p.m. Hospital, Glasgow, United Kingdom CME/CE Hours: 1 Learning Objective: describe the efficacy of pulmonary vein isolation in patients with severe heart failure. 1175-35 Cardiovascular Events in Patients with Fabry Disease: Natural History Data from the Fabry 1126-81 Adaptive Servo Ventilation Improves Cardiac Registry Dysfunction in Heart Failure Patients with Cheyne- Stokes Respiration Manesh R. Patel, Franco Cecchi, Marta Cizmarik, Ilkka Kantola, Ales Linhart, Kathy Nicholls, Jorg Strotmann, Jose Tallaj, Thi Chien Tran, Akiomi Yoshihisa, Takamasa Sato, Hiroyuki Kunii, Kazuhiko Michael L. West, Ademola Abiose, Duke University, Durham, NC Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Toshiyuki Ishibashi, Learning Objective: Better understand the cardiovascular Yasuchika Takeishi, Department of Cardiology and Hematology, complications of Fabry disease Fukushima Medical University, Fukushima, Japan

Learning Objective: Demonstrate that ASV improved cardiac function 1175-36 Prognostic Significance of Carbohydrate Antigen in HF patients with CSR. 125 in Patients with Heart Failure and Preserved Ejection Fraction

sirikarn napan, Taweewat Aussawapokee, Erol Nargileci, Ataul Qureshi, Suhail Khadra, Howard University, Washington D.C., DC, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL Learning Objective: Evaluate the prognostic value of carbohydrate antigen 125 in patients with heart failure and preserved ejection fraction JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A31

1175-37 Mutation Screening Of Sarcomere Genes MYH7, 1176-43 Concentric LV Remodeling Is Related To Decreased MYBPC3, LDB3, And TNNT2 In A Large Cohort Of Circumferential Strain And Strain Rate After Dilated Cardiomyopathy Families Exercise In Obese Patients.

Luisa Mestroni, Marco Merlo, Elisa Carniel, Dobromir Slavov, Xiao Boaz Rosen, Travis Ault, Theophilus Owan, Bhavananda Reddy, Zhu, Debra Ferguson, Ernesto E. Salcedo, Jean Cavanaugh, Andrea Ronny Jiji, Ted Adams, Ted Adams, Steven Hunt, Sheldon E. Litwin, Di Lenarda, Gianfranco Sinagra, Matthew R.G. Taylor, University University of Utah, Salt Lake City, UT of Colorado Denver, Aurora, CO, Hospital and University of Trieste, Learning Objective: To understrand the relationship between LV Trieste, Italy concentric remodeling and the change in strain and strain rate Cardiac Function and Heart FailureCardiac Function and Heart Learning Objective: Evaluate molecular epidemiology of DCM during exercise,

1175-38 Role of AMP-activated Protein Kinase in 1176-44 Impact of Angiotensin-Converting Enzyme Deletion Cardioprotection in Doxorubicin-Induced Allele as a Modifier Causing Left Ventricular Cardiomyopathy of Mice Systolic Dysfunction in Genotyped Hypertrophic Cardiomyopathy: Results from Longitudinal Study Mi-Jeong Kim, Doo Soo Jeon, Dong Il Shin, Man Young Lee, Incheon St Mary`s Hospital, Incheon, South Korea Akira Funada, Noboru Fujino, Eiichi Masuta, Akihiko Muramoto, Hidekazu Ino, Masakazu Yamagishi, Kanazawa University Hospital, Learning Objective: Activation of AMPK could be a protector from Division of Intensive Care Unit, Kanazawa, Japan, Kanazawa DXR-induced myocardial injury. University, Division of Cardiology, Kanazawa, Japan 1175-39 Endothelial Dysfunction In Peripheral Conduit Learning Objective: describe that angiotensin-converting enzyme Arteries, But Not Peripheral Resistance Arteries, In deletion allele is a modifier causing left ventricular systolic Hypertrophic Cardiomyopathy dysfunction and transition to dilated phase in genotyped hypertrophic cardiomyopathy Eshan A. Patvardhan, Kevin S. Heffernan, Craig A. Napolitano, Martin M. Maron, Richard H. Karas, Jeffrey T. Kuvin, Tufts Medical 1176-45 Prevalence of Fabry Disease in Korean Male Center, Boston, MA Patients with Left Ventricular Hypertrophy Learning Objective: Recognize that vascular dysfunction occurs Woo-Shik Kim, Toshihiro Takenaka, Bang Hun Lee, Soon Pyo Hong, in peripheral conduit arteries along with coronary microvessels Jong Chun Park, Jin-Won Jeong, Jae Ki Ko, Kyung Hoon Choe, Jae in hypertrophic cardiomyopathy. However, peripheral resistance Hyung Kim, Namsik Chung, Han-Wook Yoo, Chuwa Tei, Jong-Hoa vessels are unaffected. Bae, Kyung Hee University Medical Center, Seoul, South Korea, Korea-Japan Joint Study Group for Fabry Disease 1176 CARDIOMYOPATHIES BASIC AND CLINICAL Learning Objective: By means of a screening based on low plasma enzymatic activity, we evaluated the prevalence of Fabry disease in Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. male patients with left ventricular hypertrophy. Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1177 CARDIOMYOPATHIES BASIC AND CLINICAL II Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Enhanced Storage Reduction in Hearts of Fabry 1176-41 Georgia World Congress Center, Hall B5 Mice Mediated by Expression of an Alpha- Presentation Hour: 3:30 p.m. - 4:30 p.m. galactosidase A-Tat Fusion Enzyme CME/CE Hours: 1 Koji Higuchi, Makoto Yoshimitsu, Xin Fan, Xiaoxin Guo, Vanessa I. Rasaiah, Toshihiro Takenaka, Chuwa Tei, Jeffrey A. Medin, Ontario 1177-47 Cardiac Autonomic Neuropathy is Independently Cancer Institute, Toronto, ON, Canada, Kagoshima University, Associated with Diastolic Dysfunction in Type 2 Kagoshima, Japan Diabetes Learning Objective: demondtrate alpha-galactosidase A-Tat fusion Julian W. Sacre, Bennett Franjic, Christine L. Jellis, Thomas H. protein improve reduction of Gb3 levels in hearts of Fabry mice Marwick, The University of Queensland, Brisbane, Australia

1176-42 Therapy with Adult Bone Marrow-derived Learning Objective: identify the importance of cardiac autonomic Mesenchymal Stem Cells Ameliorates Doxorubicin- neuropathy in the aetiology of diabetic myocardial dysfunction. Induced Cardiomyopathy 1177-48 Elevated Peripheral Augmentation Index and Pulse Santosh K. Sanganalmath, Atul R. Chugh, Manjunatha R. Wave Amplitude in Patients with Hypertrophic Benakanakere, Robert J. Vincent, Greg Hunt, Roberto Bolli, Cardiomyopathy Buddhadeb Dawn, University of Kansas Medical Center, Kansas City, KS, University of Louisville, Louisville, KY Kevin Heffernan, Martin S. Maron, Eshan Patvardhan, Richard H. Karas, Jeffrey T. Kuvin, Tufts Medical Center, Boston, MA Learning Objective: demonstrate the significance of stem cells in dilated cardiomyopathy Learning Objective: interpret the systemic nature and clinical relevance of vascular dysfunction in patients with hypertrophic cardiomyopathy A32 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1177-49 Recovery of Left Ventricular Function in Patients 1178-55 Medication Dosing Adherence in Outpatients with Anthracycline-Induced Cardiomyopathy. with Heart Failure Following Implementation of a Practice-based Performance Improvement Malik Tariq Rahim, Joseph Dubin, Guilherme H. Oliveira, Jean- Intervention: Results from IMPROVE HF Bernard Durand, Daniel Lenihan, MD Anderson Cancer Center, Houston, TX Mihai Gheorghiade, Gregg C. Fonarow, Nancy M. Albert, Anne Learning Objective: To demonstrate improvement of systolic B. Curtis, Wendy Gattis Stough, J Thomas Heywood, Mark L. function in with aggressive medical therapy in anthracycline-induced McBride, Patches Johnson Inge, Mandeep R. Mehra, Christopher cardiomyopathy. M. O’Connor, Dwight Reynolds, Mary N. Walsh, Clyde W. Yancy, Medtronic, Inc., Minneapolis, MN 1177-50 The Incidence and Prognosis of Constrictive Learning Objective: To describe the impact of a practice-based Pericarditis after Pericardiocentesis for Pericardial performance improvement intervention on adherence to target Effusion doses of guideline-recommended medication therapies for heart failure. Kye Hun Kim, Lawrence Sinak, Gillian Nesbitt, Raul E Espinosa, A. Jamil Tajik, Jae K Oh, Mayo Clinic, Rochester, MN, Chonnam 1178-56 Elderly Patients are Less Likely to Receive Evidence- National University Hospital, Gwangju, South Korea Based Medications Indicated for Systolic Heart Learning Objective: know that constrictive pericarditis is not a rare Failure: Results from the Study of Anemia in a complication following pericardiocentesis, and most of them are Heart Failure Population (STAMINA-HFP) Registry transient Ileana L. Pina, Rebecca S. Boxer, Douglas D. Schocken, G. Michael Eosinophilic Heart Disease: Diagnosis and Felker, Carla A. Dupree, Alan B. Miller, Mandeep R. Mehra, Javed Cardiac Function and Heart Failure 1177-51 Indivualized Treatment Butler, J. Herbert Patterson, Lynne E. Wagoner, Jalal K. Ghali, Stephanie H. Dunlap, Kirkwood F. Adams, Jr, Case Western Bernhard Maisch, Ulrik Baandrup, Roland Moll, Sabine Pankuweit, Reserve University, Cleveland, OH, University of North Carolina, Philipps-University, Marburg, Germany Chapel Hill, NC Learning Objective: Identify the clinical histologica phenotype of Learning Objective: Describe the association of advancing age and eosinophilic heart disease. prescribing practices for systolic heart failure from the STAMINIA- HFP Registry

1178 EPIDEMIOLOGY, MEDICATION AND ADVANCED 1178-57 Obesity Paradox in Heart Failure: Is it the DIRECTIVES Accumulation or the Medication?

Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Venkataramana K. Reddy, Jun R. Chiong, K. Kim, S. Westrom, D. Georgia World Congress Center, Hall B5 Petersen, Loma Linda Medical Center, Loma Linda, CA Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: To understand the favorable prognosis behind CME/CE Hours: 1 obesity in the heart failure population

1178-52 Increasing Heart Failure Hospital Admissions with 1178-58 In the End, Its What Our Heart Failure Patients Want Decreasing New Heart Failure Patients in New Hal Skopicki, Elizabeth Maas, Stony Brook University Medical Jersey, 1996-2005 Center, Stony Brook Yingzi Deng, William J. Kostis, Abel E. Moreyra, John Pantazopoulos, Learning Objective: To identify the factors important in the decision Nora M. Cosgrove, Alan C. Wilson, John B. Kostis, for the MIDAS process concerning advanced directives in heart failure patients group, University of Medicine and Dentistry, New Jersey, New Brunswick, NJ 1178-59 Diabetes is an Independent Risk Factor for Heart Learning Objective: To examine trends of heart failure incidence, Failure among Community Dwelling Older Adults admissions and factors associated with 30-day and 1-year case fatality. Prakash C. Deedwania, V A Medical center, Birmingham, AL, University of Alabama, Birmingham, AL 1178-53 Time Trends in Cardiovascular Drug Treatment and Learning Objective: After this presentation the participant should be Cardiovascular Events in Patients with Acute Heart able to define the risk of CHF in the elderly subjects Failure

Olav R. De Peuter, Gregory Y. Lip, Olaf H. Klungel, Patrick C. Souverein, Deirdre Lane, Harry R. Büller, Anthonius De Boer, Pieter W. Kamphuisen, Academic Medical Center, Amsterdam, The Netherlands Learning Objective: describe the adherence to advised heart failure treatment and the effect on cardiovascular disease JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A33

1179 ANEMIA AND THE CARDIORENAL SYNDROME 1179-67 Should we Anticoagulate Patients With Advanced Systolic Heart Failure Without Atrial Fibrillation? Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Insights From the Beta-Blocker Evaluation of Georgia World Congress Center, Hall B5 Survival Trial (BEST) Presentation Hour: 3:30 p.m. - 4:30 p.m. Marjan U. Mujib, Mustafa I. Ahmed, Wilbert S. Aronow, Prakash CME/CE Hours: 1 Deedwania, Ali Ahmed, University of Alabama at Birmingham, Birmingham, AL 1179-61 Optimal Therapeutic Regimen for Rapid Correction Learning Objective: Understand the role of anticoagulants in of Anemia due to Iron Deficiency in Patients with FailureCardiac Function and Heart Advanced Heart Failure advanced systolic heart failure patients without atrial fibrillation.

Elisavet Kaldara, John Terrovitis, Eleni Tseliou, George Alexopoulos, 1179-68 Continuous Axial Flow Left Ventricular Assist Vanessa Kontopidi, Zafiria Margari, Argirios Ntalianis, Lampros Devices Improve Pulmonary Hemodynamics in Katsaros, Charis Matsouka, Maria Anastasiou-Nana, John N. Nanas, Patients with Severe Congestive Heart Failure. University of Athens, 3rd Cardiology Dept, Athens, Greece Ravi Rasalingam, Kyle R. Bilhorn, Stephanie N. Johnson, Carl B. Learning Objective: Determine the etiology of anemia in patients Kapadia, Majesh Makan, Nader Moazami, Julio E. Perez, Washington with severe heart failure and select the most appropriate treatment University in St Louis, St Louis, MO

1179-62 Relative Deficiency of Endogenous Erythropoietin Learning Objective: Perform non-invasive pulmonary hemodynamic and Increased Muscle Sympathetic Nerve Activity in assessment of patients with LVAD. Patients with Cardio-renal Anemia Syndrome

Shuji Joho, Yoshitaka Oda, Daisuke Harada, Tadakazu Hirai, Hiroshi 1180 CARDIOPULMONARY EXERCISE TESTING NEW Inoue, University of Toyama, Toyama, Japan FINDINGS Learning Objective: interpret that EPO depletion coexisting Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. sympathetic overactivation is frequently complicated in patients Georgia World Congress Center, Hall B5 with CRAS. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1179-63 Effectiveness of Aggressive Heart Failure Management Despite Cardiorenal Syndrome in the Sympathoinhibitory Effect is Sustained Even After Outpatient Setting: Symptom Improvement and 1180-69 Removal of Adaptive Servo-ventilation in Patients Prevention of Readmission with Heart Failure Mridula Rai, Faisal Zaeem, Dalia Giedrimiene, Lynn O’Bara, Daniel Shuji Joho, Daisuke Harada, Yoshitaka Oda, Tadakazu Hirai, Madison, Joseph Radojevic, Detlef Wencker, Hartford Hospital and Hidetsugu Asanoi, Hiroshi Inoue, University of Toyama, Toyama, University of Connecticut, Hartford, CT Japan Learning Objective: To evaluate the safety and effectiveness of high Learning Objective: identify that respiratory stabilization might dose intravenous diuretic therapy in the outpatient setting among induce sympathetic inhibition both during and after application of patients with Cardiorenal Syndrome. ASV. Clinical Outcomes of Heart Failure Patients 1179-64 Serial Studies of 6-Minute Walk Test Improve the with Anemia of Chronic Kidney Disease Taking 1180-70 Prediction of Pump Failure Death, not Sudden Erythropoietin Death, in Patients With Mild to Moderate Chronic Cynthia Jackevicius, Alberta Warner, Western University of Health Heart Failure: A 10-Year Prospective Study Sciences, Los Angeles, CA, VA Greater Los Angeles Healthcare System, Los Angeles, CA Takahisa Yamada, Yuji Okuyama, Takashi Morita, Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Taku Yasui, Michihiro Ueda, Takeshi Learning Objective: Describe the association between use of Okada, Masato Kawasaki, Yuki Kuramoto, Masatake Fukunami, erythropoietin and outcomes in CRAS patients. Osaka General Medical Center, Osaka, Japan

Effects of the Adenosine A1-antagonist Rolofylline Learning Objective: interpret the long-term prognostic significance of 1179-65 serial studies of 6-minute walk test, relating to the mode of death, on Renal Function in Acute Heart Failure Patients: in patients with chronic heart failure Results From the Protect Study

Adriaan A. Voors, Howard C. Dittrich, Barry M. Massie, Paul 1180-72 Improved Exercise Capacity In Hfnef Correlates DeLucca, George Mansoor, Michael M. Givertz, PROTECT With Improved Diastolic Function, But Unchanged Investigators and Committees, Merck & Co., Inc., Rahway, NJ Chronotropic Competence

Learning Objective: understand the effects of the adenosine Rolf Wachter, Hans-Dirk Düngen, Götz Gelbrich, Silja Schwarz, A1-antagonist rolofylline on renal function in acute heart failure Markus Löffler, Gerd Hasenfuß, Martin Halle, Burkert Pieske, Frank patients. Edelmann, University of Goettingen, Goettingen, Germany, Medical University of Graz, Graz, Austria Learning Objective: know the effects of exercise training in patients with heart failure and normal ejection fraction A34 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1180-73 Role of Oscillatory Breathing during 1181-79 Markedly Increased Circulating Rho-kinase Activity Cardiopulmonary Exercise Test for Prognostic In Patients With Chronic Heart Failure Stratification of Elderly Patients with Chronic Heart Luigi Gabrielli, Jorge Jalil, Maria P. Ocaranza, Ivan Godoy, Paul Failure McNab, Pablo Castro, Ulises Novoa, Italo Mora, Sergio Lavandero, Angela Beatrice Scardovi, Renata De Maria, Alessandro Ferraironi, Lorena Garcia, Ivonne Padilla, Pontificia Universidad Catolica, Andrea Celestini, Silvia Forte, Marina Parolini, Laura Gatto, Loretta Santiago, Chile Bordi, Sebastiano Sciarretta, Roberto Ricci, Marco Guazzi, Dr. Learning Objective: to determine the Rho kinase activity in stable Roberto Ricci, Rome, Italy chronic systolic heart failure patients with optimal medical Learning Objective: evaluate treatment.

1180-74 Clinical Importance and Interdependence of 1181-80 Galectin-3, Cardiac Structure and Function, and Long- Periodic Breathing During Asleep and Exercise in term Mortality in Patients with Acute Heart Failure Patients With Heart Failure Ravi V. Shah, Annabel A. Chen-Tournoux, Michael H. Picard, Roland Yoshitaka Oda, Shuji Joho, Daisuke Harada, Tadakazu Hirai, Hiroshi RJ van Kimmenade, James L. Januzzi, Massachusetts General Inoue, The Second Department of Internal Medicine, Toyama Hospital, Boston, MA University Hospital, Toyama, Japan Learning Objective: Identify relationships between gal-3 and cardiac Learning Objective: recognize that lower carbon dioxide level and cycle structure, and use gal-3 in addition to traditional echocardiographic length of sleep apnea contribute to periodic breathing during asleep markers of risk for enhanced risk stratification in patients with and exercise in heart failure patients with central sleep apnea. acute HF

Cardiac Function and Heart Failure Prognostic Impact Of Matrix Metalloproteinases In 1180-75 Increased Exhaled Nitric Oxide Levels in Ambulatory 1181-81 Patients with Chronic Systolic Heart Failure Patients With Acute Heart Failure Following Exercise: Importance of Pulmonary Akihiro Shirakabe, Kuniya Asai, Noritake Hata, Shiya Yokoyama, Venous Hypertension Takuro Shinada, Nobuaki Kobayashi, Kyoichi Mizuno, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan, Nippon Medical Wai Hong Wilson Tang, Akanksha Thakur, Praneet Kumar, Anne School, Tokyo, Japan Kanderian, Alan G. Borowski, Gary S. Francis, Cleveland Clinic, Cleveland, OH Learning Objective: Evaluate the prognostic impact of matrix metalloproteinases in patients with acute heart failure Learning Objective: To examinine the cardiac determinants of exhaled nitric oxide in chronic systolic heart failure 1181-82 Levels of Soluble Wnt-Inhibitors are Related to Systolic Function and Predict Outcome in Patients 1180-76 Left Ventricular Systolic Dyssynchrony is more Common in Acute Decompensated than Chronic With Chronic Heart Failure Stable Heart Failure with Reduced Ejection Fraction Erik T. Askevold, Christen P. Dahl, Kaspar Broch, Svend Aakhus, Arne Yndestad, Lars Gullestad, Pål Aukrust, Thor Ueland, Oslo University Qing Zhang, Yong-Tai Liu, Alex PW Lee, Yu-Jia Liang, Gabriel WK Yip, Hospital, Rikshospitalet, Oslo, Norway, University of Oslo, Oslo, Norway Rui-Jie Li, Jun-Min Xie, Cheuk-Man Yu, The Chinese University of Hong Kong, Hong Kong, Hong Kong, West China Hospital, Sichuan Learning Objective: identify a role for the Wnt-pathway in heart University, Chengdu, Sichuan, People’s Republic of China failure in a clinical setting. Learning Objective: identify the difference in mechanical dyssynchrony between acute and chronic systolic heart failure that 1181-84 Clinical and Prognostic Implications of Early may explain for the acute exacerbation of HF symptoms. Troponin I Increase in Trastuzumab Induced Cardiotoxicity.

1181 PREDICTORS OF REMODELING AND OUTCOME Carlo M. Cipolla, Alessandro Colombo, Rosalba Torrisi, Maria Teresa Sandri, Maurizio Civelli, Giuseppina Lamantia, Nicola Colombo, Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Michela Salvatici, Sarah Cortinovis, Maria Antonietta Dessanai, Georgia World Congress Center, Hall B5 Franco Nole’, Fabrizio Veglia, Daniela Cardinale, European Institute Presentation Hour: 3:30 p.m. - 4:30 p.m. of Oncology, Milan, Italy, Centro Cardiologico Monzino, Milan, Italy CME/CE Hours: 1 Learning Objective: identify patients at risk of TIC and of not recover from cardiac dysfunction. 1181-78 Urine 8-hydroxy-2’-deoxyguanosine is a Marker for Predicting Mortality and Morbidity as well 1181-85 Subclinical Hypothyroidism as a Risk Factor for as Evaluating the Effectiveness of Beta-blocker Cardiac Death in Patients with Chronic Heart Therapy in Patients with Chronic Heart Failure Failure, Irrespective of Renal Dysfunction: A Prospective 10-year Follow up Study Tekehisa Susa, Shigeki Kobayashi, Takeo Tanaka, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Jutaro Yamada, Takeshi Ueyama, Hiromichi Ueda, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki, Yamaguchi Yoshio Furukawa, Koji Tanaka, Yusuke Iwasakki, Taku Yasui, Takeshi University Graduate School of Medicine, Ube, Japan Okada, Masato Kawasaki, Yuki Kuramoto, Masatake Fukunami, Osaka General Medical Center, Osaka, Japan Learning Objective: Clarify that urine 8-OHdG is a useful biomarker for predicting mortality and morbidity as well as evaluating the Learning Objective: evaluate a risk factor of cardiac death in chronic effectiveness of beta-blocker therapy in patients with CHF. heart failure patients JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A35

1230 MYOCARDIAL FIBROSIS AND CARDIAC MRI 1231 MYOCARDITIS AND DILATED CARDIOMYOPATHY Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1230-35 Immunohistochemical Expression of N-cadherin is 1231-41 WITHDRAWN

Decreased in Autopsy Tissues with ARVC FailureCardiac Function and Heart 1231-42 Impact Of Dual Mutations Of Sarcomere Gene Nathaniel B. Cresswell, Fabio Tavora, Wei-Sing Chu, Erik Mont, On Clinical Manifestation Of Hypertrophic Marcello Franco, Allen Burke, Armed Forces Institute of Pathology, Cardiomyopathy Associated With Myosin-binding Washington, DC, Federal University of Sao Paulo, Sao Paulo, Brazil Protein C Gene Mutation: Evidence From Serial Learning Objective: Immunohistochemical expression of Analysis Of 50 Genotyped Patients desmosomal related proteins in ARVC Akihiko Muramoto, Noboru Fujino, Kenshi Hayashi, Katsuharu Uchiyama, Eiichi Masuta, Akira Funada, Yuichiro Sakamoto, 1230-36 Slowed Ventricular Untwisting is Related to Junichiro Yokawa, Hidekazu Ino, Masakazu Yamagishi, Division of Decreased Elastic Recoil but not to Increased Cardiology, Kanazawa University, Kanazawa, Japan Myocardial Fibrosis in Hypertrophic Cardiomyopathy Learning Objective: evaluate the risk of HCM patients Ayumi Nakaboh, Akiko Goda, Katsumi Oka, Misato Otsuka, Mika Matsumoto, Chikako Yoshida, Akiyo Eguchi, Shohei Fujiwara, 1231-43 Biopsy-Proven Active Myocarditis in Systemic Naoki Yoshimoto, Masaaki Lee-Kawabata, Takeshi Tsujino, Tohru Sclerosis Patients With Recent-Onset Cardiac Masuyama, Department of Internal Medicine, Cardiovascular Involvement Division, Hyogo College of Medicine, Nishinomiya, Japan Costantino Smaldone, Maurizio Pieroni, Maria De Santis, Gaetano Learning Objective: apply echo speckle tracking method to assess Zizzo, Mara Campioni, Antonella Ventrone, Antonia Camporeale, the degree of myocardial fibrosis with impaired LV twisting and Andrea Macchione, Anna Severino, Fulvio Bellocci, Gianfranco slowed active relaxation and/or decreased elastic recoil with slowed Ferraccioli, Filippo Crea, Catholic University of the Sacred Heart, LV untwisting in HCM. Rome, Italy

1230-37 SCN5A Mutations Associated With Dilated Learning Objective: Identify scleroderma patients with cardiac Cardiomyopathy Commonly Localize To The Voltage- involvement sensing Mechanism 1231-44 MURC encoding Muscle-Restricted Coiled-Coil is a Luisa Mestroni, William McNair, Gianfranco Sinagra, Andrea Di Novel Gene for Human Dilated Cardiomyopathy Lenarda, Debra Ferguson, Ernesto E. Salcedo, Dobromir Slavov, Dobromir Slavov, Xiao Zhu, John Caldwell, Matthew R.G. Taylor, Ali J. Marian, Gabriela Rodriguez, Grazyna Czernuszewicz, Simon Familial Cardiomyopathy Registry, University of Colorado Denver, Sims, Yanli Tan, Gerald W. Dorn, Roberta Bogaev, James Willerson, Aurora, CO, Hospital and University of Trieste, Trieste, Italy institute of Molecular Medicine, Center for Cardiovascular Genetics, Houston, TX, Texas Heart Institute, Houston, TX Learning Objective: identify molecular epidemiology of DCM Learning Objective: To identify genetic basis of heart failure 1230-38 Visualization of Myocardial Scarring/Fibrosis in Patients with Hypertrophic Cardiomyopathy: Cardiac 1231-45 Prevalence of Different Etiologies in Dilated Magnetic Resonance vs Dual Source Computed Cardiomyopathy Tomographic Imaging Sabine Pankuweit, Anette Richter, Volker Ruppert, Götz Gelbrich, Aya Kino, Jennifer Berliner, James C. Carr, Robert O. Bonow, Lubna Bernhard Maisch, Competence Net work heart failure, Dept. of Choudhury, Northwestern University, Chicago, IL Cardiology, Philipps-University Marburg, Marburg, Germany Learning Objective: Demonstrate the feasibility of ce MDCT to Learning Objective: distinguish different etiologies in DCM and will detect focal myocardium scarring in HCM patients. be able to evaluate a given patient with regard to his etiology

1230-39 Variability of Adiponectin Levels at Different Stages of Atherogenesis, from Obesity to Advanced Atherosclerosis and Heart Failure

Alexis S. Antonopoulos, Charalambos Antoniades, Dimitris Tousoulis, Antigoni Miliou, Constantinos Bakogiannis, Kyriakoula Marinou, Michael Dimosthenous, Costas Psarros, Keith M. Channon, Christodoulos Stefanadis, 1st Cardiology Department Hippokration Hospital, Athens, Greece, University of Oxford, Oxford, United Kingdom Learning Objective: Intrerpret adiponectin expression in different stages of cardiovascular disease A36 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1232 HYPERTROPHIC CARDIOMYOPATHY AND 1233 DILATED CARDIOMYOPATHY AND AMYLOIDOSIS AMYLODOSIS Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1 1233-55 Left Atrial Dysfunction in Patients with Systemic 1232-47 Induction of Apoptosis from Acute Exposure to Amyloidosis AL Amyloidosis Light Chains in Bovine Aortic Masatoshi Minamisawa, Jun Koyama, Hirohiko Motoki, Ayako Endothelial Cells and Protection by Simvastatin Takahashi, Kazunori Aizawa, Megumi Koshikawa, Hiroki Kasai, Mitchell A. Timmons, Seth Truran, Brittany Schlundt, David D. Atsushi Izawa, Takeshi Tomita, Yusuke Miyashita, Setsuo Kumazaki, Gutterman, Sergey Gurevich, Parameswaran Hari, Raymond Q. Uichi Ikeda, Shinshu University School of Medicine, Matsumoto, Migrino, Medical College of Wisconsin, Milwaukee, WI Japan Learning Objective: Identify that acute exposure of human Learning Objective: learn the existence of latent atrial dysfunction in amyloidogenic light chains induces apoptosis in bovine aortic patients with systemic amyloidosis. endothelial cells that is attenuated by simvastatin. 1233-56 Relation of Plasma Neutrophil Gelatinase- 1232-48 Peripheral Collagen Markers Predict All-cause Associated Lipocalin (NGAL) Levels with Myocardial Mortality and Cardiovascular Hospitalisation in Function and Prognosis in Patients with Chronic Cardiac Function and Heart Failure Patients with Heart Failure and Preserved Ejection Systolic Heart Failure Fraction: Results of the I-PRESERVE Collagen Sub- Kevin L. Shrestha, Richard W. Troughton, Allen G. Borowski, Allen L. study Klein, Wai Hong Wilson Tang, Cleveland Clinic, Cleveland, OH Henry Krum, Maros Elsik, Hans G. Schneider, Agata Ptaszynska, Learning Objective: Identify clinical and echocardiographic Marion Black, Peter Carson, Barry Massie, Monash University, determinants of plasma NGAL levels independent of renal function Melbourne, Australia in the setting of chronic systolic heart failure Learning Objective: suggesting a key pathophysiological role of fibrosis in this setting 1233-57 Left Atrial Volume as a Predictor of Reversible Myocardial Dysfunction in Patients with 1232-49 Targeting Frequent Ventricular Ectopic Beats as Dilated Cardiomyopathy Who Have No Delayed Therapeutic Strategy for a Form of Reversible Enhancement on Magnetic Resonance Imaging Dilated Cardiomyopathy: A Single-Center Experience Jeonggeun Moon, In Jeong Cho, Chi Young Shim, Seok-Min Kang, Deven M. Patel, Mandeep Bhargava, Wai Hong Wilson Tang, Yangsoo Jang, Namsik Chung, Jong-Won Ha, Yonsei University Cleveland Clinic Foundation, Cleveland, OH College of Medicine, Seoul, South Korea Learning Objective: identify a potentially reversible dilated Learning Objective: identify which patient will recover even in the cardiomyopathy if the culprit PVCs are ablated. absence of delayed enhancement on cardiac MRI using left atrial volume index as an predictor with high specificity. 1232-50 The Complex Interplay Between Late-enhancement on Cardiac Magnetic Resonance, Outflow 1233-58 Reduction in Ventricular Wall Thickness Following Obstruction and Left Ventricular Function During High-dose Chemotherapy and Stem-cell Exercise in Hypertophic Cardiomyopathy. An Transplantation for AL Cardiac Amyloidosis Exercise Echocardiography-Magnetic Resonance Frederick L. Ruberg, Vaishali Sanchorawala, John Berk, Kathleen T. Study Finn, Martha Skinner, David C. Seldin, Hans Meier-Ewert, Boston University School of Medicine/Boston Medical Center, Boston, MA Elena Biagini, Massimiliano Lorenzini, Guido Rocchi, Fabio Coccolo, Rossella Fattori, Francesco Lai, Claudia Borghi, Angelo Branzi, Learning Objective: Describe the ventricular remodeling that Claudio Rapezzi, Institute of Cardiology, S.Orsola-Malpighi Hospital, occurs following successful stem-cell transplantation for cardiac Bologna University, Bologna, Italy, Italy amyloidosis. Learning Objective: Understand the complex pathophysiology of Detection of Autoimmune T-cell Responses hypertophic cardiomyopathy during exercise 1233-59 to Cardiac Troponin I in Idiopathic Dilated Cardiomyopathy using Enzyme-Linked Immunospot 1232-51 High Prevalence of Metabolic Gene Mutations in Patients Referred for Hypertrophic Cardiomyopathy Assay Genetic Testing Carmel M. Halley, Jason M. Lappe, Anne C. Cotleur, Wai Hong Wilson Tang, Heart and Vascular Institute, Cleveland Clinic Tom E. Callis, Lisa Susswein, William Ferguson, Michael J. Foundation, Cleveland, OH Ackerman, Benjamin A. Salisbury, PGxHealth, New Haven, CT, Mayo Clinic, Rochester, MN Learning Objective: Understand the complexity of autoimmune T-cell response to pathogenesis of idiopathic dilated cardiomyopathy Learning Objective: Describe the spectrum and prevalence of sarcomeric and metabolic gene mutations in suspected HCM patients. JACC March 9, 2010 ABSTRACTS: Cardiac Function and Heart Failure A37

1234 HYPERTROPHIC CARDIOMYOPATHY AND AORTIC 1235 BETABLOCKERS AND HEART FAILURE; NEW FUNCTION FINDINGS Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1234-61 Elevated Pulse Pressure Is Associated with an 1235-69 Which Beta Blocker Restores Left Ventricular FailureCardiac Function and Heart Abnormal Blood Pressure Response to Exercise in Synchronisation Better? A Randomised Trial Patients with Hypertrophic Cardiomyopathy Of Carvedilol And Metoprolol In Patients With Idiopathic Dilated Cardiomyopathy And Heart Kevin Heffernan, Martin S. Maron, Eshan Patvardhan, Richard H. Failure Karas, Jeffrey T. Kuvin, Tufts Medical Center, Boston, MA Learning Objective: understand the role of pulse pressure in MEHMET KAYA, BAHADIR SARLI, YAT Y. LAM, ESMA G. KAYA, predicting high risk patients with hypertrophic cardiomyopathy. ALI DOGAN, TUGRUL INANC, OZGUR GUNEBAKMAZ, MIKAIL YARLIOGLUES, NIHAT KALAY, RAMAZAN TOPSAKAL, ERCIYES UNIVERSITY, KAYSERI, Turkey 1234-62 Myocardial Systolic Deformation and Torsion Assessed by Speckle Tracking for Early Detection Learning Objective: Both carvedilol and metoprolol similarly restore of Epirubicin-Induced Cardiac Dysfunction in intraventricular and interventricular synchronization and LV reverse Asymptomatic Patients with Breast Cancer remodeling in patients with idiopathic DCMP and heart failure.

Maria Florescu, Stefania Magda, Oana Aurelia Enescu, Dan Jinga, 1235-70 Beta-blocker Intensification in Ambulatory Heart Mircea Cinteza, Dragos Vinereanu, University Hospital of Bucharest, Failure Patients and Short-term Association with Bucharest, Romania, University of Medicine and Pharmacy Carol Subsequent Hospitalization Davila, Bucharest, Romania Larry Allen, Pamela N. Peterson, Chan Zeng, Christina L. Clark, Learning Objective: Identify early cardiac dysfunction in Susan Shetterly, Joann Lindenfeld, David J. Magid, Frederick A. asymptomatic patients with breast cancer treated with epirubicin Masoudi, University of Colorado Denver, Division of Cardiology, Aurora, CO, Kaiser Permanente of Colorado, Instutite for Health Pre-Existing Left Ventricular Dysfunction in Patients 1234-63 Research, Denver, CO Undergoing Kidney Transplantation: Implications for Patient Selection,Cardiac Risk Stratification and Learning Objective: Consider potential adverse effects of beta- Impact on Post Transplant Outcomes blocker intensification in heart failure patients and potential methods for preventing these events. Joseph Chattahi, Vanji Karthikeyan, Haitham Kanneh, Jayanth Koneru, Sylvia Hayek, Anita Patel, Mariella Goggins, Karthikeyan 1235-72 Impact of Baseline Volume Status and LVEF on All- Ananthasubramaniam, Henry Ford Health System, Detroit, MI Cause Mortality in the BEST Trial

Learning Objective: Demonstrate that low EF in patients with chronic Inderjit S. Anand, Mona Fiuzat, Christopher O’Connor, JoAnn kidney disease should not preclude them from getting kidney Lindenfeld, Peter Carson, Eric Eicchorn, James Udelson, Michael transplant as it is not associated with worse graft function or overall Domanski, Gordon Davis, Michael Bristow, VAMC Minneapolis, mortality Minneapolis, MN, University of Colorado, Denver, CO

1234-64 Long-term Outcome of Percutaneous Septal Learning Objective: Identify appropriate patient populations for use Ablation for Symptomatic Hypertrophic Obstructive of BBs Cardiomyopathy 1235-73 Higher Neurohormonal Activation Is Associated with Lothar Faber, Dirk Welge, Hubert Seggewiss, Detlef Hering, Olaf a Positive Response to Carvedilol in Patients with Oldenburg, Dieter Horstkotte, Department of Cardiology, Heart Systolic Heart Failure Center North Rhine-Westphalia, Ruhr-University Bochum, Bad Oeynhausen, Germany, Medical Clinic I, Leopoldina Hospital, Roberto Spoladore, Gabriele Fragasso, Altin Palloshi, Angelo Schweinfurt, Germany Corti, Guido Lattuada, Barbara Colombo, Massimo Locatelli, Anna Salerno, Alberto Margonato, Cardiothoracic and Vascular Learning Objective: interpret long-term data after interventional Department, Clinical Cardiology, San Raffaele Hospital, Milan, Italy treatment of symptomatic HOCM Learning Objective: To indentify heart failure patients responder and 1234-65 Aortic Stiffness, In Addition to Myocardial Scarring not-responder to carvedilol therapy and Mitral Regurgitation, Incrementally Predicts Outcomes in Severe Ischemic Cardiomyopathy 1235-74 Left Ventricular Ejection Fraction Decrease after Patients Response to Beta Blocker Therapy in Patients with Non-Ischemic Cardiomyopathy Ashley M. Lewis, Deborah H. Kwon, Zoran B. Popovic, Carmel M. Halley, Paul Schoenhagen, Scott D. Flamm, Brian P. Griffin, Randall Patrick Hourani, Iosif Kelesidis, Christopher Varughese, Ronald C. Starling, Milind Y. Desai, Cleveland Clinic, Cleveland, OH Zolty, Albert Einstein College of Medicine / Montefiore, Bronx, NY Learning Objective: To understand various multi-modality Learning Objective: Measure the frequency of left ventricular imaging predictors of outcomes in patients with severe ischemic ejection fraction decline after initial response to beta blocker cardiomyopathy therapy in patients with non-ischemic cardiomyopathy. A38 ABSTRACTS: Cardiac Function and Heart Failure JACC March 9, 2010

1235-75 The Nondifferential Effect of Chronic -blocker 1236-81 Acute Coronary Syndromes in Patients with Heart Treatment on Left Ventricular Function and Failure with Preserved Ejection Fraction: Myocardial Glucose Uptake in Heart Failure Patients A Harbinger of Death?

Biykem Bozkurt, Mariana Bolos, Maithili Shenoy, Haby Henary, Lance John R. Teerlink, Michael R. Zile, Michel White, Alan B. Miller, K. Gould, Michael E. DeBakey Veterans Affairs Medical Center, Jose Lopez-Sendon, William C. Little, Markus Haass, Inderjit Houston, TX, Baylor College of Medicine, Houston, TX S. Anand, Agata Ptaszynska, Scott J. Hetzel, Michel Komajda, John JV McMurray, Barry M. Massie, Peter E. Carson, I-Preserve Learning Objective: Identify effects of beta blocker tratment on Investigators, San Francisco VAMC/UCSF, San Francisco, CA myocardial glucose uptake in heart failure patients Learning Objective: Evaluate the important role that ACS 1235-76 Nebivolol in Primary Prevention of Chemotherapy- hospitalization has on mortality on patients with HFPEF. Induced Cardiomyopathy 1236-82 Early Estrogen Replacement Prevents Lusitropic Mehmet Kaya, Ozgur Gunebakmaz, Metin Ozkan, Hasan Akkaya, Impairment Following Ovariectomy in Middle-Aged Nihat Kalay, Esma G. Kaya, Ali Dogan, Tugrul Inanc, Mustafa Cynomolgus Monkeys Dikilitas, Ibrahim Ozdogru, Erciyes University, Kayseri, Turkey Leanne Groban, Jewell Jessup, Thomas Register, Wake Forest Univ Learning Objective: This study shows that use of prophylactic School of Medicine, Winston-Salem, NC nebivolol have cardioprotective effects in patients with chemotherapy-induced cardiotoxicity Learning Objective: Describe the effects of estrogen replacement on left ventricular diastolic function in postmenopausal female cynomologous monkeys 1236 HEART FAILURE WITH PRESERVED EJECTION Cardiac Function and Heart Failure FRACTION AND DIASTOLIC FUNCTION 1236-84 Aldosterone Antagonism Increases Post-Exercise Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Recruitment of Systolic Myocardial Motion Over Left Ventricular Lateral Wall in Hypertensive Patients Georgia World Congress Center, Hall B5 with Diastolic Heart Failure Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Yi-Chih Wang, Chih-Chieh Yu, Fu-Chun Chiu, Chia-Ti Tsai, Ling-Ping Lai, Juey-Jen Hwang, Jiunn-Lee Lin, National Taiwan University 1236-78 Baseline Systolic Blood Pressure and Outcomes in Hospital, Taipei, Taiwan,ROC Patients with Heart Failure and Preserved Ejection Learning Objective: identify the effects of aldosterone antagonism Fraction - Results from the I-Preserve Trial on segmental myocardial motion in diastolic heart failure Inderjit S. Anand, Scott J. Hetzel, Alan B. Miller, Peter E. Carson, Severity and Acute Changes in Diastolic Function William H. Gaasch, Markus Haass, William C. Little, Jose Lopez- 1236-85 Sendon, Barry M. Massie, John J. McMurray, Agata Ptaszynska, with Vasoactive Therapy in Decompensated Systolic John R. Teerlink, Michel White, Michael R. Zile, VA Medical Center, Heart Failure Minneapolis, MN Carmel M. Halley, Allen G. Borowski, Kevin Shrestha, James D. Learning Objective: To understand the relation between blood Thomas, Wai Hong Wilson Tang, Heart and Vascular Institute, pressure and adverse outcomes in patients with heart failure and Cleveland Clinic Foundation, cleveland, OH preserved ejection fraction Learning Objective: Describe the changes with therapy in diastolic function in decompensated systolic heart failure 1236-79 Intravenous GP531, an Adenosine Regulating Agent, Improves Left Ventricular Diastolic Function in Dogs with Chronic Heart Failure

Hani N. Sabbah, Mengjun Wang, Itamar Ilsar, Ramesh C. Gupta, Alice Jiang, Michael S. Sabbah, Kaitlin Dye, Henry Ford Hospital, Detroit, MI Learning Objective: Evaluste the effects of GP531, an adenosine regulating agent, on LV distolic function in dogs with heart failure.

1236-80 Do Patients with Diastolic Heart Failure Progress to Systolic Heart Failure?

Sultan A. Mirzoyev, Theophilus E. Owan, Omar F. AbouEzzeddine, Barry A. Borlaug, David J. Huschka, William D. Edwards, Margaret M. Redfield, Mayo Clinic and Foundation, Rochester, MN, University of Utah, Salt Lake City, UT Learning Objective: Assess interval EF measurements from hospitalization for DHF to death among DHF patients who had autopsy. JACC March 9, 2010 ABSTRACTS: Congenital Cardiology Solutions A39

ORAL CONTRIBUTIONS

907 CATHETER AND SURGICAL INTERVENTIONS IN 11:00 Risk Factors for Long Term-Outomes in Balloon CONGENITAL HEART DISEASE: FROM FETUS TO Valvuloplasty for Aortic Stenosis ADULT Shiraz Maskatia, Frank F. Ing, Henri Justino, Matthew A. Crystal, Charles E. Mullins, Raphael J. Mattamal, E. O’Brian Smith, Monday, March 15, 2010, 10:30 a.m. - 12:00 p.m. Christopher J. Petit, Section Pediatric Cardiology, Department of Georgia World Congress Center, Room B401 Pediatrics, Baylor College of Medicine, Houston, TX CME/CE Hours: 1.5 Learning Objective: identify factors that predict long term outcome in balloon valvuloplasty for aortic stenosis 10:30 Current Status of Patients with a Biventricular Circulation Following Fetal Aortic Valvuloplasty for 11:15 Arrhythmia Recurrence in Adult Patients with Single Evolving Hypoplastic Left Heart Syndrome Ventricle Physiology Following Surgical Fontan Lindsay R. Freud, Doff B. McElhinney, Audrey C. Marshall, Gerald R. Conversion Marx, Pedro J. del Nido, Emile A. Bacha, Carol B. Benson, Louise E. Jamil A. Aboulhosn, Ryan J. Williams, Kalyanam Shivkumar, and (Pediatric Cardiology Adult Congenital Disease) Heart Wilkins-Haug, James E. Lock, Wayne Tworetzky, Children’s Hospital Congenital Solutions Cardiology Mark Plunkett, Rakhi Barkowski, Pamela Miner, Hillel Laks, Brian Boston, Boston, MA, Brigham and Women’s Hospital, Boston, MA Reemtsen, Kevin Shannon, John Child, University of California Los Learning Objective: Describe the current clinical and Angeles, Los Angeles, CA echocardiographic status of patients with a biventricular circulation Learning Objective: Evaluate the incidence of atrial tachy-arrhythmia following fetal aortic valvuloplasty for evolving hypoplastic left heart recurrence following conversion from RA-PA Fontans to total syndrome (HLHS). cavopulmonary connection in adults. Home Monitoring Program Reduces Interstage 10:45 Ventricular Function at the Time of Systemic Mortality Following the Modified Norwood Operation 11:30 Atrioventricular Valve Replacement in Congenitally Gail E. Wright, Jennifer Bond, Dannielle Toner, Jana Norris, Frank L. Corrected Transposition of the Great Arteries Hanley, V. Mohan Reddy, Lucile S. Packard Childrens’ Hospital at Predicts Long-Term Ventricular Function Stanford University, Palo Alto, CA François-Pierre Mongeon, Heidi M. Connolly, Joseph A. Dearani, Learning Objective: evaluate the efficacy of an interstage home Zhuo Li, Carole A. Warnes, Mayo Clinic, Rochester, MN monitoring program for reducing interstage mortality following the modified Norwood operation Learning Objective: Identify surgical indications for systemic atrioventricular valve replacement in adult patients with congenitally corrected transposition of the great arteries. A40 ABSTRACTS: Congenital Cardiology Solutions JACC March 9, 2010

POSTER CONTRIBUTIONS

1063 AORTIC ISSUES IN MARFAN SYNDROME AND 1063-397 Doppler Echocardiography after Bentall Procedure ADULT CONGENITAL HEART DISEASE Compared to an Isolated Aortic Valve Prostheses Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Paul Luijendijk, Michiel S. Evers, Berto J. Bouma, Renee BA van den Brink, Barbara JM Mulder, Academic Medical Centre, Amsterdam, Georgia World Congress Center, Hall B5 The Netherlands, Interuniversity Cardiology Institute (ICIN), Utrecht, Presentation Hour: 9:30 a.m. - 10:30 a.m. The Netherlands CME/CE Hours: 1 Learning Objective: interpret the importance of baseline echocardiographic examination in patients after a Bentall 1063-392 The Role of Imaging the Distal Aorta in Adults with procedure, because of significant higher transvalvular pressure Marfan Syndrome gradients compared to isolated AVR Angela T. Yetman, Melanie D. Everitt, Primary Children’s Medical Center, Salt Lake City, UT 1063-398 Absence of Abdominal Aneurysm in Adults with Coarctation and/or Bicuspid Aortic Valve - Is This Learning Objective: demonstrate the frequency of distal aortic Really An “Aortopathy”? disease in adults with Marfan Syndrome. Anurag Sahu, Vidu Garg, Bethany Boettner, Stephen Cook, The Ohio 1063-393 Aortic Distensibility is a Predictor for Aortic Events State University, Columbus, OH, Nationwide Children’s Hospital, in Patients with Marfan Syndrome: a 12 year- Columbus, OH survival analysis Learning Objective: Identify the unique aortopathy associated with Coarctation of the Aorta and Bicuspid Aortic Valve and its Piet De Witte, Teodora Radonic, Kim Laan, Aeilko H. Zwinderman, limited involvment of the thoracic aorta without involvement of the Barbara JM Mulder, Maarten Groenink, Academic Medical Center, abdominal aorta. Amsterdam, The Netherlands, Interuniversity Cardiology Institute, Utrecht, The Netherlands Learning Objective: identify high risk Marfan patients 1064 RIGHT VENTRICLES AND SINGLE VENTRICLES IN

Congenital Cardiology Solutions Congenital ADULT CONGENITAL HEART DISEASE (Pediatric Cardiology and Adult Congenital Heart Disease) Adult Congenital Cardiology(Pediatric and 1063-395 Are Guidelines Recommending Primary Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Echocardiography Adequate to Screen For Aortic Complications in Patients With Bicuspid Aortic Georgia World Congress Center, Hall B5 Valve? Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Shane Tsai, Mira Trivedi, Beth Boettner, Curt Daniels, The Ohio State University, Columbus, OH, Nationwide Children’s Hospital, Serial Changes in Systemic Ventricular Volume Long Columbus, OH 1064-401 After Fontan Operation: Insight Into Better Patient Learning Objective: Evaluate accuracy of echocardiography Care compared to cardiac MRI in detecting aortic complications in patients with bicuspid aortic valve Iki Adachi, Hajime Ichikawa, Koji Kagisaki, Takayoshi Ueno, Haruki Ide, Takaya Hoashi, Kazuhiko Ishimaru, Masaki Taira, Toru Kuratani, Junjiro Kobayashi, Toshikatsu Yagihara, Yoshiki Sawa, Osaka 1063-396 Assessment Of Endothelial Function, Numbers Of Circulating Endothelial Progenitor Cells, University Graduate School of Medicine, Osaka, Japan, National Cardiovascular Center, Osaka, Japan Soluble Adhesion Molecules And Serum Levels Of Inflammatory Markers Suggest The Absence Of Learning Objective: evaluate the long-term effect of chronic volume Relevant Endothelial Dysfunction In Contemporary unloading on a single ventricle sustaining the Fontan circulation Patients With Repaired Coarctation 1064-402 Prognostic Implications of Stress Testing in Adults Robert M. Radke, Gerhard-Paul Diller, Michaela Duck, Stefan Orwat, with Single Ventricle Congenital Heart Disease Aleksander Kempny, Thomas Thum, Helmut Baumgartner, Adult congenital and valvular heart disease center, University Hospital of Brenton Bauer, Jamil Aboulhosn, Ryan Williams, University of Muenster, Muenster, Germany, Hannover Medical School, Institute California Los Angeles, Los Angeles, CA for Molecular and Translational Therapeutic Strategies, Hannover, Learning Objective: Evaluate the usefulness of stress test Germany parameters in predicting the risk of adverse events in adults with Learning Objective: interpret the significance of endothelial single ventricle congenital heart disease. dysfunction in contemporary patients after surgical repair of aortic coarctation. 1064-403 Longitudinal Exercise Function of Patients with Repaired Tetralogy of Fallot

Alaina K. Kipps, David M. Harrild, Erik Lewis, Dionne A. Graham, Andrew J. Powell, Jonathan Rhodes, University of California, San Francisco, San Francisco, CA, Children’s Hospital Boston, Boston, MA Learning Objective: Describe the longitudinal exercise capacity in patients with repaired tetralogy of Fallot. JACC March 9, 2010 ABSTRACTS: Congenital Cardiology Solutions A41

1064-404 Atrial Baffle Complications Following the Mustard 1118-393 Mortality in Congenital Heart Disease; are Operation in Young Adults with D-Transposition of Governmental Registries Reliable for Cause of the Great Arteries Death?

Sheetal Patel, Disha Shah, Kavitha Chintala, Peter P. Karpawich, C. Zomer, Cuno S.P.M. Uiterwaal, Enno T. van der Velde, Jan G.P. Children’s Hospital of Michigan, Detroit, MI Tijssen, Edwin C.M. Mariman, Carianne L. Verheugt, Petronella G. Pieper, Folkert J. Meiboom, Diederick E. Grobbee, Barbara J.M. Learning Objective: learn incidence and catheter based treatment Mulder, Academic Medical Center, Amsterdam, The Netherlands, of atrial baffle complications following Mustard operation for University Medical Center, Utrecht, The Netherlands d-transposition of great arteries Learning Objective: At the conclusion of this presentation, 1064-405 Relationship of Right Ventricular Restrictive participants will be able to evaluate the use of governmental Physiology with Pulmonary Regurgitation and Age of registries for cause of death. Repair in Patients with Repaired Tetralogy of Fallot 1118-395 High Risk Cardiovascular Disease and Pregnancy: Jimmy C. Lu, Timothy B. Cotts, Prachi P. Agarwal, Anil K. Attili, Adam Can We Change the Risk of Maternal Mortality and L. Dorfman, University of Michigan, Ann Arbor, MI, University of

Complications? and (Pediatric Cardiology Adult Congenital Disease) Heart

Kentucky, Lexington, KY Congenital Solutions Cardiology Stephen R. Crumb, David F. Colombo, Stephen C. Cook, Patricia L. Learning Objective: Describe the relationship of right ventricular Woods, Curt J. Daniels, Nationwide Children’s Hospital, Columbus, restrictive physiology with right ventricular size and pulmonary OH, The Ohio State University, Columbus, OH insufficiency. Learning Objective: Describe the impact of multidisciplinary 1064-407 Accuracy of Right Ventricular Volume and Function collaboration on high risk pregnancy in women with cardiovascular Analysis in Patients with Systemic Right Ventricles disease Using Knowledge Based Reconstruction 1118-396 Circumstances of Death in Adult Congenital Heart David J. Sahn, Mary-Pierre Waiss, Philip Kilner, Wim Helbing, Harold Disease Litt, Karen Stout, Emanuela Valsangiacomo Buechel, Alan Shurman, Oregon Health & Science University, Portland, OR, VentriPoint, Inc., A. C. Zomer, Cuno S.P.M. Uiterwaal, Enno T. v.d. Velde, Lambert Seattle, WA F.M. van den Merkhof, L. H.B. Bauer, J. M. Ansink, L. Cozijnsen, Petronella G. Pieper, Folkert J. Meiboom, Diederick E. Grobbee, Learning Objective: appreciate complex RV geometry Barbara J.M. Mulder, Academic Medical Center, Amsterdam, The Netherlands, University Medical Center, Utrecht, The Netherlands 1064-408 Two-dimensional Echocardiography For Assessment Of Right Ventricular Volumes Revisited: An MRI Learning Objective: At the conclusion of this presentation, Comparison Study In Adults With Repaired participants will be able to describe circumstances of death in adult congenital heart disease Tetralogy Of Fallot Matthias Greutmann, May Ling Mah, Daniel Tobler, Patric Biaggi, 1118-397 Risk Factors for Death Following Adult Congenital Andrew Crean, Candice Silversides, Erwin Oechslin, Toronto General Heart Surgery in Pediatric Hospitals Hospital, Toronto, ON, Canada Yuli Y. Kim, Kimberlee Gauvreau, Emile Bacha, Michael J. Landzberg, Learning Objective: Estimate the importance of standardized two- Oscar J. Benavidez, Children’s Hospital Boston, Boston, MA dimensional echocardiographic measurements for assessment of right ventricular dimensions. Learning Objective: Identify risk factors for inpatient death in adults who undergo congenital heart surgery in pediatric hospitals

1118 MORBIDITY AND MORTALITY IN ADULTS WITH 1118-398 Intra-Atrial Reentry Tachycardia Ablation in Adults CONGENITAL HEART DISEASE With Congenital Disease - Curative or Just a Successful Procedure? Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Jeffrey P. Moak, Marco A. Mercader, Vicki Freedenberg, Mujeeb Presentation Hour: 3:30 p.m. - 4:30 p.m. Basit, Jonathan R. Kaltman, Karen S. Kuehl, Children’s National Medical Center, Washington, DC, George Washington University, CME/CE Hours: 1 Washington, DC

1118-392 Long Term Outcome of Implantable Cardioverter Learning Objective: Identify the likely outcome of arrhythmias after Defibrillators in Adults with Congenital Heart ablation of IART in adult patiens with congenital heart disease. Disease 1118-399 Clinical and Echocardiographic Follow-up after Zeliha Koyak, Bart A. Mulder, Isabelle C. van Gelder, Joris R. de Surgical Ventricular Septal Defect Closure in Adults Groot, Marcelle D. Smit, Pascal F.H.M. van Dessel, Alexander H. Maass, Arthur A.M Wilde, Petronella G. Pieper, Reinoud E. Knops, François-Pierre Mongeon, Harold M. Burkhart, Naser M. Ammash, Barbara J.M. Mulder, Academic Medical Center, Amsterdam, The Joseph A. Dearani, Zhuo Li, Carole A. Warnes, Heidi M. Connolly, Netherlands, University Medical Center Groningen, Groningen, The Mayo Clinic, Rochester, MN Netherlands Learning Objective: Describe the outcomes of surgical ventricular Learning Objective: demonstrate that implantable cardioverter septal defect closure in adults. defibrillators in adults with congenital heart disease is a safe and effective therapy A42 ABSTRACTS: Congenital Cardiology Solutions JACC March 9, 2010

1119 ADULT CONGENITAL HEART DISEASE 1119-407 Safety and Efficacy of Intravenous Ultrasound Contrast in Evaluating Surgically Corrected Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Congenital Heart Disease Patients with Difficult Georgia World Congress Center, Hall B5 Windows Presentation Hour: 3:30 p.m. - 4:30 p.m. Shelby Kutty, Christopher Danford, Scott E. Fletcher, Christopher C. CME/CE Hours: 1 Erickson, David A. Danford, John D. Kugler, Joan Olson, Thomas R. Porter, University of Nebraska Medical Center, Childrens Hospital 1119-401 Atherosclerosis Progression in Adult Post- and Medical Center, Omaha, NE Coarctectomy Patients Learning Objective: Understand the role of ultrasound contrast in Paul Luijendijk, Eric E. de Groot, Joris JW Vriend, Johan J. Gort, congenital heart disease Berto J. Bouma, Barbara JM Mulder, Academic Medical Centre - Department of Cardiology, Amsterdam, The Netherlands, 1119-408 Effect of Patent Foramen Ovale Closure Device on Interuniversity Cardiology Institute, Utrecht, The Netherlands Aortic and Tricuspid Valve Function

Learning Objective: demonstrate that CIMT increase over time is Patrick T. Siegrist, Nazmi Krasniqi, Christiane Gruner, Matthias similar in patients after coarctation repair compared to unaffected Greutmann, Thomas F. Luscher, Roberto Corti, University Hospital controls, despite an increased baseline CIMT compared to healthy Zurich, Zurich, Switzerland controls. Learning Objective: Identify possible complications of percoutanous 1119-402 Benefits of Exercise Prescriptions in Adults with closure of patent foramen ovale Congenital Heart Disease

Jennifer L. Smith, Anne M. Valente, Mark E. Alexander, Tracy J. Curran, 1173 CARDIAC FUNCTION AND CARDIOMYOPATHY IN Julieanne O’Neill, Kathleen M. Solly, Caitlyn O’Brien-Joyce, Michael J. PEDIATRIC PATIENTS Landzberg, Jonathan Rhodes, Children’s Hospital, Boston, MA Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Learning Objective: appreciate the potential benefits and limitations Georgia World Congress Center, Hall B5 of an exercise prescription program for adults with congenital heart disease. Presentation Hour: 9:30 a.m. - 10:30 a.m. Congenital Cardiology Solutions Congenital

(Pediatric Cardiology and Adult Congenital Heart Disease) Adult Congenital Cardiology(Pediatric and CME/CE Hours: 1 1119-403 Transfer Destinations and Risk Factors for No Follow-up and ‘No Appropriate Follow-up’ in Young 1173-392 Long-Term Outcomes of Dilated Cardiomyopathy Adults with Congenital Heart Disease after Leaving Presenting During Childhood: Results From a Pediatric Cardiology National Population-Based Study of Childhood Cardiomyopathy Eva Goossens, Ine Stephani, Deborah Hilderson, Marc Gewillig, Werner Budts, Kristien Van Deyk, Philip Moons, Center for Health Peta M. a. Alexander, Katherine Lee, Piers Daubeney, Christian Services and Nursing Research, Leuven, Belgium Turner, Terry Robertson, Alan Nugent, Andrew Davis, James Ramsay, Robert Justo, Tara Bharucha, Ingrid King, Robert G. Weintraub, Learning Objective: identify risk factors that are associated with National Australian Childhood Cardiomyopathy Study, Melbourne, ‘no follow-up’ and ‘no appropriate follow-up’ in young adults with Australia congenital heart disease after leaving pediatric cardiology. Learning Objective: Describe outcomes in a population-based study of childhood dilated cardiomyopathy. 1119-404 Clinical Study on Mortality and Morbidity of Patients with Eisenmenger Syndrome -Japanese Multicenter study 1173-393 Altered Cardiac Function and Cardiac Steatosis in Overweight Adolescents: Does Obesity Hisanori Sakazaki, Koichiro Niwa, Makoto Nakazawa, Tsutomu Saji, Cardiomyopathy Evolve in Pediatric Age? Toshio Nakanishi, Motoki Takamuro, Michihiko Ueno, Hitoshi Katou, Shinichi Takatsuki, Seiki Matsushima, Namiko Kojima, Fukiko Ichida, Gautam K. Singh, Bernadette Vitola, Mark Holland, Samuel Klein, Shigetoyo Kogaki, Sachiko Kido, Yoshio Aragaki, Kenji Waki, Teiji Washington University School of Medicine, St. Louis, MO Akagi, Kunitaka Jo, Atsushi Souuchi, Kenji Suda, Study committee Learning Objective: Describe cardiac dysfunction in adolescents of Japanese Society of Pediatric Cardiology and Cardiology Surgery, with obesity and its association with non alcoholic fatty liver Hyogo prefectural Amagasaki Hospital, Amagasaki, Japan disease and insulin resistance Learning Objective: demonstrate prognosis and risk factor 1173-395 Biventricular Pacing Leads To A Sustained 1119-405 Relationship of Orifice Geometry of Anomalous Increase In Cardiac Index In Infants With Electrical Coronary Arteries Arising from Opposing Coronary Dyssynchrony Following Surgery For Congenital Sinuses (ACAOS) to Functional Myocardial Ischemia Heart Disease and Clinical Outcomes: Evaluation by 64-Detector Mark Friedberg, Steven Schwartz, Hargen Zhang, Maria Ilina, Row Coronary Computed Tomographic Angiography Elizabeth A. Stephenson, The Hospital for Sick Children, Toronto, Kelly Axsom, Troy LaBounty, Jin-Ho Choi, James K. Min, Fay Y. Lin, ON, Canada Weill-Cornell Medical Center, New York City, NY Learning Objective: Describe the effect of Biventricular Pacing Learning Objective: describe the correlates and outcomes of as a therapy for low cardiac output in the setting of electrical anomalous coronary arteries as evaluated by cardiac computed dyssynchrony in infants after surgery for congenital heart disease tomographic angiography JACC March 9, 2010 ABSTRACTS: Congenital Cardiology Solutions A43

1173-396 Left Ventricular Noncompaction in a Pediatric 1174-402 Evaluation of Bacterial Cellulose as a New Patch Population: Predictors of Survival Material for Closure of Muscular Ventricular Septal Defects Warren Zuckerman, Marc E. Richmond, Rakesh K. Singh, Carroll J. Sheila, Thomas J. Starc, Linda J. Addonizio, New York Presbyterian Nora F. Lang, Matthias Sigler, Elena Merkel, Franziska Fuchs, Dieter Hospital/Columbia University Medical Center, New York, NY, New Schumann, Dieter Klemm, Friederike Kramer, Anja Meyer, Franz York Presbyterian/Cornell University Medical Center, New York, NY Freudenthal, Christian Schroeder, Susanne Mayer, Heinrich Netz, Rainer Kozlik-Feldmann, University Hospital Grosshadern, Munich, Learning Objective: determine the likely clinical outcome of a Germany pediatric patient with left ventricular noncompaction. Learning Objective: Evaluation of biocompatibility 1173-397 Long-Term Outcomes of Hypertrophic Cardiomyopathy Presenting During Childhood: 1174-403 Total Anomalous Pulmonary Venous Return--Impact Results from a National Population-Based Study of of Preoperative Obstruction and Early Elective Childhood Cardiomyopathy Repair on Outcome and Need for Prolonged Mechanical Ventilatory Support Peta M. a. Alexander, Katherine Lee, Alan Nugent, Christian Turner, (Pediatric Cardiology and (Pediatric Cardiology Adult Congenital Disease) Heart

Terry Robertson, Piers Daubeney, Andrew Davis, James Ramsay, Peter C. Frommelt, David Sheridan, Michele A. Frommelt, S. Bert Congenital Solutions Cardiology Robert Justo, Tara Bharucha, Ingrid King, Robert G. Weintraub, Litwin, James S. Tweddell, Medical College of Wisconsin, Milwaukee, National Australian Childhood Cardiomyopathy Study, Melbourne, WI, Children’s Hospital of Wisconsin, Milwaukee, WI Australia Learning Objective: identify risk factors for morbidity and mortality Learning Objective: Describe outcomes from a population-based after repair of total anomalous pulmonary venous return surgery. study of childhood hypertrophic cardiomyopathy. 1174-404 Parental Knowledge Regarding Life-Long Congenital 1173-398 Genetic and Viral Genome Analysis of Childhood Cardiac Care Cardiomyopathy: The PCMR/PCSR Experience Susan M. Fernandes, Amy Verstappen, Kathy Ackerman, Elizabeth Jeffrey A. Towbin, Lynn Sleeper, John L. Jefferies, Steven Colan, E. Adams, Cheryl Barton, Petar Breitinger, Stephen Crumb, Kirsten Steven A. Webber, Charles E. Canter, Daphne T. Hsu, Stephanie Dummer, Paul Khairy, Michael J. Landzberg, Rachel Linstead M. Ware, James D. Wilkinson, E. John Orav, Steven E. Lipshultz, Goldsmith, JoAnn Nieves, Arwa Saidi, Masato Takahashi, Sonja Cincinnati Children’s Medical Center, Cincinnati, OH, University of Ziniel, Roberta Williams, Children’s Hospital, Boston, MA Miami, Miami, FL Learning Objective: Understand that parents of children with Learning Objective: describe genetic variants and viral causes of moderate and complex congenital heart disease need education cardiomyopathy and myocarditis in children regarding life long cardiac care.

1173-399 NT- Pro BNP Versus BNP And Their Correlation With 1174-405 Mechanical Circulatory Support in the Treatment of Cardiac Function In Pediatric Transplant Or Heart Children with Acute Fulminant Myocarditis: A Single Failure Patients Center 14-Year Experience

Chesney Castleberry, Stanley Lo, Kathryn Tillman, Gail Stendahl, Ivan Wilmot, Mary C. McGarry, David L. Morales, John L. Jefferies, Kwang Woo Ahn, Stuart Berger, Steven Zangwill, Children’s Hospital Texas Children’s Hospital, Houston, TX of Wisconsin, Milwaukee, WI, Medical College of Wisconsin, Learning Objective: Participants will be able to identify mechanical Milwaukee, WI circulatory support as a successful therapy for acute myocarditis in Learning Objective: Determine correlation between BNP and pro children. BNP in pediatric heart failure or transplantation. 1174-407 Cardiac Magnetic Resonance Can Obviate The Need For Routine Cardiac Catheterization Prior to Fontan: 1174 PEDIATRIC CARDIOLOGY A Study of 3 Groups Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Mark A. Fogel, Thomas Pawlowski, Matthew Harris, Kevin Georgia World Congress Center, Hall B5 Whitehead, Marc Keller, Jack Rome, Childrens Hospital of Presentation Hour: 9:30 a.m. - 10:30 a.m. Philadelphia, Philadelphia, PA CME/CE Hours: 1 Learning Objective: Identify the issues surrounding routine cardiac cath prior to Fontan and how CMR alleviates it 1174-401 Route of Delivery Does Not Impact Perinatal Hemodynamics in Infants with Hypoplastic Left 1174-408 Histopathologic Evaluation of Patent Ductus Heart Syndrome Arteriosus Stents after Hybrid Palliation of Amy Peterson, Michael D. Quartermain, Anne Ades, Jack Rychik, The Hypoplastic Left Heart Syndrome Children’s Hospital of Philadelphia, Philadelphia, PA Matthew Egan, Aaron J. Trask, Peter B. Baker, Jonathan Lawrence, Learning Objective: Describe the impact mode of delivery has on Elena Ladich, Renu Virmani, Sharon L. Hill, Pamela A. Lucchesi, perinatal hemodynamics in infants with Hypoplastic Left Heart Mark Galantowicz, John P. Cheatham, John P. Kovalchin, Nationwide Syndrome. Children’s Hospital, Columbus, OH Learning Objective: Describe the histology of neointima formation in PDA stents A44 ABSTRACTS: Congenital Cardiology Solutions JACC March 9, 2010

1228 FETAL AND NEONATAL CARDIOLOGY 1228-399 Defining Normative Values and Dispersion in Outcome Measures after Cardiac Surgery in Infants Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Mark Scheurer, Kimberlee Gauvreau, Andrew M. Atz, Peter Laussen, John E. Mayer, Jr., Jane Newburger, Children’s Hospital Boston, Presentation Hour: 3:30 p.m. - 4:30 p.m. Boston, MA CME/CE Hours: 1 Learning Objective: Understand the national variation of outcome measures after infant cardiac surgery 1228-392 Insights into Ventricular Mechanics in the Unlooped Heart: Ventricular Twisting and Untwisting in a Right Atrial Isomerism Single Ventricle Fetal Mouse Model 1229 PRACTICAL ISSUES IN PEDIATRIC CARDIOLOGY David J. Sahn, Lowell H. Frank, Linda Leatherbury, Uyen T. Truong, Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Cecelia W. Lo, Qing Yu, Petra S. Niemann, Oregon Health & Science Georgia World Congress Center, Hall B5 University, Portland, OR, Children’s National Medical Center, Washington, DC Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 Learning Objective: understand fetal ventricular-ventricular interaction 1229-401 Patent Foramen Ovale in Children with Migraine Headache 1228-393 Right Atrial Dysfunction in Fetuses with Severe Tricuspid Valve Disease: Novel Experience with Rachel T. McCandless, Cammon B. Arrington, Douglas C. Nielsen, Velocity Vector Imaging James F. Bale, Jr., L. LuAnn Minich, Primary Children’s Medical Center, University of Utah, Salt Lake City, UT Lisa W. Howley, Nee Szce Khoo, Anita Moon-Grady, Fayeza Alrais, Jean Trines, Tiina Ojala, Lisa K. Hornberger, University of Alberta, Learning Objective: Decribe the association of patent foramen ovale Edmonton, AB, Canada, University of California, San Francisco, CA and pediatric migraine headache with aura. Learning Objective: Describe the differences in fetal right atrial and 1229-402 Oxygen Consumption Recovery Following a Maximal left ventricular function in tricuspid valve disease when compared to Bicycle Exercise Test in Children: A Potential Tool for

Congenital Cardiology Solutions Congenital right heart obstructive lesions and normals.

(Pediatric Cardiology and Adult Congenital Heart Disease) Adult Congenital Cardiology(Pediatric and Assessing Cardiac Performance in Children 1228-395 Fetal Cardiovascular Response to Increased Tajinder P. Singh, Mark Alexander, Tracy Curran, Yael H. Rhodes, Afterload with Ductal Constriction in the Third Jonathan Rhodes, Children’s Hospital Boston, Boston, MA Trimester: An Experimental Study in Sheep Learning Objective: To understand the predictors of oxygen David J. Sahn, Juha R. Rasanen, Leah S. Bernard, Roger Hohimer, consumption recovery following an exercise test in children Muhammad Ashraf, Minjuan Zheng, Petra S. Niemann, Xiaokui Li, Lowell E. Davis, Oregon Health & Science University, Portland, OR 1229-403 Outpatient Evaluation of Innocent Murmurs in Children: Utilization Benchmarking. Learning Objective: understand ultrasound evaluation of fetal cardiac mechanics Patrick A. Frias, Dara A. Rastegar, William T. Cole, William T. Mahle, Children’s Healthcare of Atlanta Sibley Heart Center, Atlanta, GA, 1228-396 Studies of Fetal Left Ventricular Mechanics by an Emory University School of Medicine, Atlanta, GA Advanced New 4D Dense Speckle Tracking Program Learning Objective: Define benchmarking data for echo utilization David J. Sahn, Xubo Song, Andrij Myronenko, Muhammad Ashraf, in the outpatient evaluation of innocent murmurs by pediatric Roger R. Hohimer, Juha R. Rasanen, Oregon Health & Science cardiologists. University, Portland, OR 1229-404 Adverse Events Associated with Oral Learning Objective: understand fetal 3D echo Anticoagulation of Patients with Congenital Heart Disease 1228-397 The Myocardium of Fetuses with Endocardial Fibroelastosis Contains a Paucity of B and T Cells Michael Colon, Andrea Benin, Veronika Northrup, Nancy Rollinson, Compared with Normal Controls Yale University, New Haven, CT

Nisha Fernandes, The Hospital for Sick Children, Toronto, ON, Learning Objective: Identify risk factors for adverse events related Canada to oral anticoagulation in congential heart disease patients Learning Objective: describe the differences in myocardial cellular 1229-405 The Prevalence of Atrial Level Shunts in Children immune activity in fetuses with EFE and DCM or structural heart with Migraine disease compared to normal controls Christa Miliaresis, John Fahey, Susan Levy, Francine Testa, Yale New 1228-398 Comparison of Norwood Shunt Types: Do the Haven Hospital, New Haven, CT, Bridgeport Hospital, Bridgeport, CT Outcomes Differ 5 Years Later? Learning Objective: identify the relationship between PFO and Eric Graham, Jacob W. Phillips, Sinai C. Zyblewski, Girish S. Shirali, children with migraine Scott M. Bradley, Geoffrey A. Forbus, Varsha M. Bandisode, Andrew M. Atz, Medical University of South Carolina, Charleston, SC Learning Objective: Identify how the shunt type at Norwood procedure effects outcomes 5 years later JACC March 9, 2010 ABSTRACTS: Congenital Cardiology Solutions A45

1229-407 Cost And Efficiency Analysis Of Thiopental Versus 1280-396 Bicuspid Aortic Valve in Children: Are We Chloral Hydrate For Sedating Children During Overestimating the Risk? Echocardiography William T. Mahle, Patricio A. Frias, Children’s Healthcare of Atlanta, Carol A. Stefaniak, John Kovalchin, Steve Cassidy, Bethany Atlanta, GA Hashiguchi, Karen Texter, Nationwide Children’s Hospital, Columbus, Learning Objective: To analyze the clinical significance of the dilated OH aorta in children with isolated bicuspid aortic valve Learning Objective: Identify the time saving benefits of sedating patients for pediatric echocardiography using thiopental vs. chloral 1280-397 Aortic Valve Reintervention after Balloon Aortic hydrate. Valvuloplasty for Congenital Aortic Stenosis: Intermediate and Late Follow-up 1229-408 Implementing Pulse Oximetry Screening for Critical Congenital Heart Disease in a Community Nursery David W. Brown, Amy E. Dipilato, Erin C. Chong, James E. Lock, Doff B. McElhinney, Children’s Hospital, Boston, MA Gerard R. Martin, Elizabeth A. Bradshaw, Jeffrey Becker, Sandra Learning Objective: Describe intermediate and long-term results of Cuzzi, Sharon Kiernan, Nancy Nagel, Children’s National Medical

balloon aortic valvuloplasty for congenital aortic stenosis. and (Pediatric Cardiology Adult Congenital Disease) Heart Center, Washington, DC, Holy Cross Hospital, Silver Spring, MD Congenital Solutions Cardiology

Learning Objective: Identify best practice for implementation of 1280-398 Early Cardiac Catheterization Following Congenital pulse oximetry screening for detection of critical congenital heart Heart Surgery Is Not Associated with Increased Risk disease in the newborn nursery. for Serious Adverse Events

Joshua W. Salvin, Lisa Bergersen, Peter C. Laussen, Sarah A. Teele, 1280 OUTCOMES IN PEDIATRIC CARDIOLOGY Audrey C. Marshall, John E. Mayer, Doff McElhinney, Children’s Hospital Boston, Boston, MA Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Learning Objective: Evaluate the safety and efficacy of early post Presentation Hour: 9:30 a.m. - 10:30 a.m. operative catheterization following congenital heart surgery CME/CE Hours: 1 1281 TRANSPLANTATION AND OTHER ADVANCED 1280-392 Outcome of the Left Ventricle in Children and Young CARDIAC THERAPIES IN CHILDREN Adults with Severe Combined Aortic and Mitral Valve Regurgitation Compared to Isolated Lesions Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Tom L. Gentles, Kirsten A. Finucane, Jonathan Mervis, Nigel J. Presentation Hour: 9:30 a.m. - 10:30 a.m. Wilson, Starship Children’s Hospital, Auckland, New Zealand CME/CE Hours: 1 Learning Objective: describe risk factors for left ventricualr dysfunction after surgery for severe aortic and mitral regurgitation 1281-401 Comparative Evaluation of two Surgical Techniques for Pediatric Heart Transplantation: Is the bicaval 1280-393 Establishment of a Dedicated Single Ventricle approach better? Program Reduces Interstage Mortality and Improves Weight Gain in Infants with Single Liwen Tang, Thomas J. L’Ecuyer, Sanjeev Aggarwal, children’s Ventricle hospital of michigan, detroit, MI

Christopher J. Petit, Connie Cephus, David Nelson, Raphael Learning Objective: evaluate the poutcome of type of transplant Mattamal, Elena O’Campo, Texas Children’s Hospital, Houston, TX surgery

Learning Objective: appreciate the benefits of a dedicated single 1281-402 Long Term Left Ventricular Systolic Alteration ventricle team as it pertains to interstage death and infant growth Persists After Repair Of Anomalous Left Coronary rates. Artery Arising From The Pulmonary Artery

1280-395 Long-Term Pulmonary Regurgitation Following Andreea Dragulescu, Beatrice Bonello, Pascal Amedro, Alain Fraisse, Balloon Valvuloplasty for Pulmonary Stenosis: Risk Timone Children’s Hospital, Marseille, France Factors and Relationship to Exercise Capacity and Learning Objective: describe long term sequellae after repair of Ventricular Volume and Function anomalous origin of the left coronary artery from the pulmonary artery David M. Harrild, Andrew J. Powell, Trang X. Trang, Tal Geva, James E. Lock, Jonathan Rhodes, Doff B. McElhinney, Children’s Hospital Boston, Boston, MA 1281-404 Platelet Reactivity And Endothelial Function In Children Of Patients With Premature Acute Learning Objective: Identify the impact of long-term pulmonary Myocardial Infarction regurgitation on exercise capacity Gaetano A. Lanza, Giancarla Scalone, Ilaria Coviello, Roberto Nerla, Irma Battipaglia, Lucy Barone, Alessia De Nisco, Angelica Delogu, Fabio Infusino, Filippo Crea, Università Cattolica del Sacro Cuore, Rome, Italy Learning Objective: To evaluate endothelial and platelet function in offsprings of premature acute myocardial infarction patients A46 ABSTRACTS: Congenital Cardiology Solutions JACC March 9, 2010

1281-405 The Successful Use of Oral Sildenafil in Right Ventricular Dysfunction and High Pulmonary Vascular Resistance After Pediatric Heart Transplantation

Rakesh Singh, Marc Richmond, Tara B. Giblin, Rose Rodriguez, Jonathan M. Chen, Linda J. Addonizio, Columbia University Medical Center, New York, NY Learning Objective: describe the use of oral sildenafil in right ventricular dysfunction and high pulmonary vascular resistance after pediatric heart transplantation.

1281-407 10 Year Experience with Surgical Unroofing of Anomalous Origin of a Coronary Artery from the Opposite Sinus with an Interarterial Course

Peter C. Frommelt, Stuart Berger, Michele A. Frommelt, Kathy A. Mussatto, James S. Tweddell, Medical College of Wisconsin, Milwaukee, WI, Children’s Hospital of Wisconsin, Milwaukee, WI Learning Objective: demonstrate an understanding of the anatomy and symptoms assocated with anomalous origin of a coronary artery with an interarterial course and surgical unroofing as a potential repair technique

1281-408 Validation of a Risk Prediction Model for In-hospital Mortality Following Pediatric Heart Transplantation

Christoher S. d. Almond, Kimberlee Gauvreau, Charles E. Canter,

Congenital Cardiology Solutions Congenital Gary E. Piercey, TP Singh, Children’s Hospital Boston, Boston, MA, (Pediatric Cardiology and Adult Congenital Heart Disease) Adult Congenital Cardiology(Pediatric and St. Louis Children’s Hospital, St. Louis, MO Learning Objective: Demonstrate the utility of a risk prediction model for post-heart transplant survival in children. JACC March 9, 2010 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids A47

ORAL CONTRIBUTIONS

904 WHAT’S NEW ABOUT HIGH-DENSITY 908 ANTIPLATELET AGENTS AND CORONARY ARTERY LIPOPROTEIN? DISEASE Monday, March 15, 2010, 8:00 a.m. - 9:30 a.m. Monday, March 15, 2010, 10:30 a.m. - 12:00 p.m. Georgia World Congress Center, Room B408 Georgia World Congress Center, Room B408 CME/CE Hours: 1.5 CME/CE Hours: 1.5

8:00 Effect of Dalcetrapib Plus Pravastatin on 10:30 Use of Nonsteroidal Anti-Inflammatory Drugs and Lipoprotein Metabolism in Dyslipidemic Patients: Risk of Acute Myocardial Infarction and All-Cause Results of a Phase 2b Dose-Ranging Study Mortality in the Australian Veteran Community

Christie M. Ballantyne, Michael Miller, Eric J. Niesor, Tracy Burgess, Arduino A. Mangoni, Richard J. Woodman, Paraskevi Gaganis, David Kallend, Evan A. Stein, Baylor College of Medicine, Houston, Andrew L. Gilbert, Kathleen M. Knights, Flinders University, TX, Hoffman-LaRoche Ltd, Basel, Switzerland Adelaide, Australia, University of South Australia, Adelaide, Australia Learning Objective: At the conclusion of this presentation, Learning Objective: evaluate the impact of NSAID use on the risk of participants will be able to describe the effects of dalcetrapib on acute myocardial infarction and all-cause mortality in elderly patients the lipoprotein profile in dyslipidemic patients. 10:45 Gastrointestinal Symptoms in Low-Dose Aspirin 8:15 Measures of High-Density Lipoprotein Quantity and Users in the Community: A Comparison Between Quality Predict Cardiovascular Outcome at all Levels Plain and Buffered Aspirin Of Myeloperoxidase Hypertension, Prevention and Lipids Jeroen Jaspers Focks, Marc A. Brouwer, Etiënne G. Cramer, Merel Stephen J. Nicholls, Wai Hong Wilson Tang, Danielle M. Brennan, M. Tielemans, Leo G. van Rossum, Ties Eikendal, Robert J. Laheij,

Stanley L. Hazen, The Cleveland Clinic Foundation, Cleveland, OH Jan B. Jansen, Martijn G. van Oijen, Radboud University Nijmegen General Cardiology: Medical Centre, Nijmegen, The Netherlands Learning Objective: demonstrate the cardiovascular risk prediction of myeloperoxidase with parameters reflecting quantity and quality Learning Objective: distinguish the effect of different forms of of HDL aspirin on dyspeptic symptoms.

8:30 Triple Therapy with Statin, Fibrate (Trilipix) and 11:00 The Antiplatelet Effect of Aspirin Is Reduced by Niacin Raises High-Density Lipoprotein Cholesterol Proton Pump Inhibitors in Patients with Coronary without Changing Apolipoprotein A-I Levels Artery Disease

Richard L. Dunbar, Ramprasad Gadi, Amanda Baer, Ashwani Gupta, Morten Würtz, Erik L. Grove, Steen D. Kristensen, Anne-Mette Hvas, Arshad Javed, Christine Lord, Daniel J. Rader, John Millar, University Aarhus University Hospital, Skejby, Aarhus, Denmark of Pennsylvania, Philadelphia, PA Learning Objective: The frequently used combination of aspirin and Learning Objective: evaluate the sequential effects of adding a proton pump inhibitors might reduce the cardiovascular protection novel fibrate and extended-release niacin to background statin by aspirin. therapy in terms of clinical lipids and apolipoprotein kinetics. 11:15 Upfront Clopidogrel Use and the Efficacy and Safety 8:45 Fenofibric and Nicotinic Acid Progressively of Early Eptifibatide Use in Patients with Acute Suppress Postprandial Triglyceridemia in Statin- Coronary Syndrome: An Analysis from the Early Treated Patients with Low High-Density Lipoprotein versus Delayed Provisional Eptifibatide in Acute Cholesterol Coronary Syndromes (EARLY ACS) Trial

Richard L. Dunbar, Ramprasad Gadi, Amanda Baer, Harsh Goel, Tracy Wang, Jennifer A. White, Robert P. Giugliano, Pierluigi Tricoci, Aurangzeb Baber, Mohammad Rehan, Daniel J. Rader, John Millar, Robert A. Harrington, Gilles Montalescot, Uwe Zeymer, Frans Van University of Pennsylvania, Philadelphia, PA de Werf, Paul W. Armstrong, Eugene Braunwald, Robert M. Califf, L. Kristin Newby, Duke Clinical Research Institute, Durham, NC Learning Objective: evaluate progressive effects of fenofibric acid and nicotinic acid on postprandial triglyceridemia in statin-treated Learning Objective: describe the efficacy and safety of early eptifibatide patients with low HDLc with upfront clopidogrel use in ACS patients undergoing angiography.

11:30 Impact of Low Dose Aspirin on Acetylcholine- Induced Coronary Artery Spasm and 12 Month Clinical Outcome

Ji Young Park, Seung Woon Rha, Kanhaiya L. Poddar, Sureshkumar Ramasamy, Lin Wang, Byoung Geol Choi, Ji Bak Kim, Seung Yong Shin, Un Jung Choi, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Korea University Guro Hospital, Seoul, South Korea Learning Objective: We evaluated the impact of low dose asprin on acetylcholine induced coronary artery spasm and 12 month clinical outcome A48 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids JACC March 9, 2010

POSTER CONTRIBUTIONS

1017 INFLAMMATION AND ATHEROSCLEROSIS 1017-90 Cross-Sectional Relationships of Urinary Albumin Excretion With Osteoprotegerin, C-reactive Protein Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. and Asymmetric Dimethylarginine in Essential Georgia World Congress Center, Hall B5 Hypertension Presentation Hour: 9:30 a.m. - 10:30 a.m. Kyriakos Dimitriadis, Konstantinos Tsioufis, Dimitris Tsiachris, CME/CE Hours: 1 Alexandros Kasiakogias, Eirini Andrikou, Antigoni Miliou, Elli Stefanadi, Andreas Michaelides, Christodoulos Stefanadis, First 1017-86 Association of Tendon Xanthomas with Carotid Cardiology Clinic, University of Athens, Hippokration Hospital, Atherosclerosis in Patients with Familial Athens, Greece Hypercholesterolemia Learning Objective: describe the relationships of urinary albumin Constantina Masoura, Christos Pitsavos, Konstantinos Aznaouridis, excretion with osteoprotegerin, asymmetric dimethylarginine and Skoumas Ioannis, Charalambos Vlachopoulos, Vassiliki Metaxa, C-reactive protein in hypertension. Themistoclis Psarros, Christodoulos Stefanadis, Athens Medical School, Hippokration Hospital, Athens, Greece 1018 DIABETES, METABOLIC SYNDROME AND Learning Objective: appreciate the presence of tendon xanthomas ATHEROSCLEROSIS as a marker of subclinical atherosclerosis in patients with familial hypercholesterolemia Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 1017-87 Disparities in Association of Various Lipid Ratios Presentation Hour: 9:30 a.m. - 10:30 a.m. on the Location and Severity of Atherosclerosis in CME/CE Hours: 1 Different Vascular Beds

Palaniappan Manickam, Ankit Rathod, Apurva Badheka, Pawan 1018-92 Atorvastatin Worsens Glucose Metabolism and Hari, Vikas Veeranna, Jyotiranjan Pradhan, Sony Jacob, Luis Afonso, Insulin Sensitivity in Hypercholesterolemic Patients Wayne State University, Detroit, MI Kwang K. Koh, Michael Quon, Seung H. Han, Kyounghoon Lee, Learning Objective: identify the strong association of LDL/HDL Gachon University, Incheon, South Korea, NIH, Bethesda, MD particle ratio with subclinical carotid and peripheral atherosclerosis Learning Objective: identify and to appreciate the lack of association of lipid ratios and coronary calcium score. 1018-93 Impact of Pioglitazone on Coronary Atherosclerosis General Cardiology: General in Patients with Non- and Early-Diabetes: A 1017-88 Relationship of Fetuin-A to lipid abnormalities associated with Metabolic Syndrome in Type 2 Prospective Randomized Study with Intravascular Ultrasound Hypertension, Prevention and Lipids Hypertension, Diabetes Mellitus (T2DM)

Luis H. Eraso, Naeema Ginwala, Atif N. Qasim, Nehal N. Mehta, Nobuyuki Komiyama, Toshihiko Kikutani, Tomomi Koizumi, Tohru Muredach P. Reilly, Unniversity of Pennsylvania, Cardiovascular Tamaki, Tetsuro Yamazaki, Atsushi Sakamato, Eiji Takagi, Shigeyuki Institute, Philadelphia, PA Nishimura, Saitama International Medical Center, Hidaka, Japan Learning Objective: Understand the role of fetuin-A, a novel Learning Objective: identify the effect of pioglitazone on coronary biomarker of cardiovascular mortality and heterogeneous forms of atherosclerosis vascular disease, has with the atherogenic dyslipidemia associated with metabolic syndrome 1018-94 Microalbuminuria in Non-Diabetic Patients with Metabolic Syndrome is strongly associated with 1017-89 Lipid and Lipoprotein Biomarkers and the Risk of Systemic Inflammation Ischemic Stroke in Postmenopausal Women Pawan K. Hari, Vikas Veeranna, Palaniappan Manickam, Rajeev Jeffrey S. Berger, Aileen McGinn, Barbara Howard, Lewis Kuller, Sudhakar, Mengistu Simegn, Sandeep Zalawadiya, Sony Jacob, Luis JoAnn Mason, Jim Otvos, David Curb, Charles Eaton, Robert Kaplan, Afonso, Wayne State University, Detroit, MI John Lynch, Daniel Rosenbaum, Sylvia Wassertheil-Smoller, New Learning Objective: Identify that microalbuminuria in non-diabetic York University School of Medicine, New York, NY, Albert Einstein patients with metabolic syndrome is strongly associated with College of Medicine, Bronx, NY systemic inflammation Learning Objective: identify which lipid or lipoprotein markers are independently associated with an increased risk of ischemic stroke 1018-95 Dose Dependant Effects of N-3 polyunsaturated Fatty Acids on Insulin Resistance and Inflammatory Marker in Metabolic Syndrome

Jang-Young Kim, Sang-Woo Han, Jungkyung Sung, NamSeok Lee, Jun-Won Lee, Young-Jin Youn, Byung-Su Yoo, Junghan Yoon, Seung- Hwan Lee, Kyung-Hoon Choe, Wonju College of Medicien, Yonsei Univeristy, Wonju, South Korea Learning Objective: In this study, N-3 PUFA clearly demonstrate the improvement of insulin resistance and anti-inflammatory effects in metabolic syndrome. JACC March 9, 2010 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids A49

1018-96 Insulin Sensitizing Therapy Compared to Insulin 1019-101 Long-Term Efficacy of Fenofibric Acid 135 mg in Providing Therapy for Type 2 Diabetes Mellitus: Combination with Rosuvastatin 20 mg in Patients Effects on Low Density Lipoprotein Particle with Mixed Dyslipidemia Characteristics by Nuclear Magnetic Resonance Peter H. Jones, Terry A. Jacobson, Carolyn M. Setze, Darryl J. Sleep, LipoProfile-III Maureen T. Kelly, Laura A. Williams, James C. Stolzenbach, Baylor Trevor J. Orchard, David Robertson, Marnie Bertolet, James Otvos, College of Medicine, Houston, TX, Abbott, Abbott Park, IL Tom Donner, Teik Ooi, Georgia Pambianco, Jamal Rana, Donald Learning Objective: Comprehend that the lipid efficacy of fenofibric Smith, Lynn Zoiopoulos, BARI 2D Study Group, University of acid + rosuvastatin was sustained for 2 years in patients with Pittsburgh, Pittsburgh, PA mixed dyslipidemia, without evidence of cumulative toxicity or late- Learning Objective: Understand the differential effects of insulin onset adverse events sensitizing and insulin providing therapies on NMR lipoproteins in type 2 diabetes 1020 HYPERTENSION EFFECTS ON THE LEFT VENTRICLE 1019 COMBINATION DRUG THERAPY IN THE Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. TREATMENT OF HYPERLIPIDEMIA Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. Georgia World Congress Center, Hall B5 CME/CE Hours: 1 Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1020-103 Adult Left Ventricular Mass Is Associated with

Long-term Blood Pressure Variability Beginning Hypertension, Prevention and Lipids 1019-98 Randomized Comparison of Rosuvastatin Plus in Childhood in Blacks, but not in Whites: The Ezetimibe Versus Simvastatin Plus Ezetimibe: Bogalusa Heart Study

Results of the GRAVITY Study General Cardiology: Wei Chen, Litao Ruan, Sathanur R. Srinivasan, Gerald S. Berenson, Christie M. Ballantyne, Rick Schiebinger, Valerie Cain, Baylor College Tulane University, New Orleans, LA of Medicine and Methodist DeBakey Heart and Vascular Center, Learning Objective: Evaluate the predictive value of blood pressure Houston, TX, AstraZeneca, Wilmington, DE variations from childhood for left ventricular hypertrophy in Learning Objective: evaluate the efficacy of combination therapies adulthood, independent of blood pressure levels, among black using either rosuvastatin with ezetimibe or simvastatin with individuals. ezetimibe for lipid lowering and LDL-C goal attainment. 1020-104 Distinct Mechanisms for Diastolic Dysfunction in 1019-99 Effect of Ezetimibe Plus Low-Dose Atorvastatin Diabetes Mellitus and Pressure-overload versus Double-Dose Atorvastatin on Insulin Ines Pires, Giuseppina Palladini, Nádia Gonçalves, Jolanda van der Resistance and Lipid Metabolism in Coronary Velden, Daniel Moreira-Gonçalves, Francesco Salinaro, Walter J. Artery Disease Patients with or without Metabolic Paulus, Hans WM Niessen, Stefano Perlini, Adelino F. Leite-Moreira, Syndrome Faculdade de medicina da Universidade do Porto, Porto, Portugal Keiko Goshima, Kazuki Fukui, Tomoaki Shimizu, Yukiko Morita, Learning Objective: Distinguish between cardiac structural and Atsushi Wada, Tomohiko Shigemasa, Yasuyuki Mochida, Reimin functional abnormalities induced by pressure overload and diabetes Sawada, Takei Takahiro, Noriaki Iwahashi, Satoshi Umemura, mellitus Kazuo Kimura, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan 1020-105 Differential Effects of Ambulatory Isolated Systolic Learning Objective: evaluate the effect of high-dose atrovastatin and and Isolated Diastolic Hypertension in Cardiac low-dose atrovastatin plus ezetimibe combination therapy on lipid Adaptations in the Early Stages of Hypertension metabolism and insulin resistance in the patients with and without METS. Efstathios Taxiarchou, Konstantinos Tsioufis, Dimitris Roussos, Dimitris Syrseloudis, Dimitris Chatzis, Anastasia Mazaraki, Eirini Andrikou, Ioannis Andrikou, Christodoulos Stefanadis, First Beyond LDL-Cholesterol Reduction: Effect of 1019-100 Cardiology Clinic, University of Athens, Hippokration Hospital, Ezetimibe in Combination with Atorvastatin on Athens, Greece Oxidized LDL-Cholesterol in Patients with Coronary Artery Disease or Coronary Artery Disease Learning Objective: evaluate the prognostic role of the components Equivalent of ambulatory blood pressure load in hypertension

Rabih R. Azar, Georges Badaoui, Antoine Sarkis, Mireille Azar, Hermine Aydanian, Serge Harb, Guy Achkouty, Roland Kassab, Hotel Dieu de France Hospital, Beirut, Lebanon Learning Objective: understand the effects of ezetimibe on oxidized LDL and on LDL subfractions A50 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids JACC March 9, 2010

1020-106 Chronic Kidney Disease and Left Ventricular 1021-112 Do Angiotensin Receptor Blockers Increase the Risk Hypertrophy as Prognosticators of Cardiovascular of Angioedema? Events in Hypertension Harikrishna J. Makani, Franz H. Messerli, Aleksander Korniyenko, Dimitris Tsiachris, Konstantinos Tsioufis, Costas Thomopoulos, Jorge Romero, Maria Elena De Benedetti Zunino, Jorge Silva Enciso, Dimitris Syrseloudis, Elena Vezali, Antonis Moulakakis, Dimitris St. Luke’s Roosevelt Hospital and Columbia University College of Tousoulis, Ioannis Kallikazaros, Christodoulos Stefanadis, First Physicians and Surgeons, New York, NY Cardiology Clinic, University of Athens, Hippokration Hospital, Learning Objective: describe the incidence of angioedema with Athens, Greece angiotensin receptor blockers and compare it with the incidence of Learning Objective: distinguish the comparative prognostic role of angioedema with ACE inhibitors and other drug classes. left ventricular hypertrophy and chronic kidney disease for major CV events 1021-113 Adverse Drug Events Resulting in Admissions to a Cardiac Care Unit Myocardial Injury in Hypertensive Heart 1020-107 Heather A. Wroblewski, James E. Tisdale, Brian R. Overhaolser, Erika Yamamoto, Yukihito Sato, Tadashi Miyamoto, Ryoji Taniguchi, Joanna R. Kingery, Richard J. Kovacs, Purdue University, West Masanao Toma, Rei Fukuhara, Kiyoto Nishi, Sayaka Saijo, Yohei Lafayette, IN Tanada, Naoki Takahashi, Taisuke Goto, Takuma Sawa, Takashi Learning Objective: Decribe common adverse drug events leading to Kiyonaka, Takako Fujiwara, Hisayoshi Fujiwara, Yoshiki Takatsu, hospital admission to cardiac care units Hyogo Prefectural Amagasaki Hospital, Hyogo, Japan Learning Objective: identify the relationship between NT-proBNP 1022 PHARMACOLOGY/HORMONES/LIPIDS—BASIC and heart-type fatty acid-binding protein (H-FABP) in hypertensive patients. Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 1021 NOVEL EFFECTS OF COMMON CARDIAC Presentation Hour: 9:30 a.m. - 10:30 a.m. MEDICATION CME/CE Hours: 1

Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. 1022-115 Hyperglycemia And Oxidation Impairs The Impact Georgia World Congress Center, Hall B5 Of High-density Lipoproteins On Endothelial Cell Presentation Hour: 9:30 a.m. - 10:30 a.m. Growth And Migration. CME/CE Hours: 1 Xing Chen, Ruliang Li, Woineshet Zenebe, MyNgan Duong, Stephen

General Cardiology: General J. Nicholls, The Cleveland Clinic, Cleveland, OH 1021-109 Acute Administration of Vardenafil Improves Arterial Stiffness and Wave Reflections Learning Objective: demonstrate the influence of HDL and its major apolipoproteins on endothelial cell growth and migration Hypertension, Prevention and Lipids Hypertension, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, Konstantinos Safflower Seed-derived Des-1,2-apoA1 1022-116 milano Rokkas, Athanasios Aggelis, Katerina Baou, Athanasios Askitis, Reduces Atherosclerosis in Hypercholesterolemic Christodoulos Stefanadis, 1st Department of Cardiology, Apolipoprotein E (-/-) Mice Hippokration Hospital, Athens Medical School, Athens, Greece Kuang-Yuh Chyu, Juliana Yano, Xiaojun Li, Jianchang Zhou, Wai Man Learning Objective: Describe the beneficial effects of vardenafil on Lio, Cheryl Chan, Paul C. Dimayuga, Bojan Cercek, Cory L. Nykiforuk, arterial function. Yin Shen, Maurice M. Moloney, Prediman K. Shah, Cedars-Sinai Heart Institute, Los Angeles, CA, SemBioSys Genetics Inc., Calgary, 1021-110 Pharmacodynamic Effects and Clinical Outcomes AB, Canada of Clopidogrel and Ticlopidine with or without a Learning Objective: Evaluate the therapeutic potential of Safflower Proton-pump Inhibitor seed-derived Des-1,2-apoA1milano in atherosclerotic disease. Shuichi Oshima, Katuso Noda, Hironobu Fukushima, Shinichi Nakamura, Izsumi Taniguchi, Fumihito Kugimiya, Kenichiro Higa, 1022-117 High Maintenance-dose Of Clopidogrel (150 mg/d) Tsunenori Nishijima, Shinsuke Hanatani, Division of Cardiology, Can Not Overcome the Loss-of-function Effect of the Kumamoto Central Hospital, Kumamoto, Japan Cytochrome 2C19 Polymorphism

Learning Objective: assess the association between the use of a Young-Hoon Jeong, In-Suk Kim, Yongwhi Park, Seok-Jae Hwang, PPI, measurements of platelet function, and clinical outcomes for Choong Hwan Kwak, Jin-Yong Hwang, Gyeongsang National patients treated with clopidogrel or ticlopidine. University Hospital, Jinju, South Korea Learning Objective: doubling dose of clopidogrel can not overcome Pedal Edema Associated with Calcium Antagonists - 1021-111 the loss-of-function effect of CYP2C19 polymorphism Incidence and Withdrawal Rate

Harikrishna J. Makani, Maria Elena De Benedetti Zunino, Christopher Di Giorgio, Jorge Romero, Gangadhara Kabbli, Jorge Silva Enciso, Franz H. Messerli, St. Luke’s Roosevelt Hospital and Columbia University College of Physicians and Surgeons, New York, NY Learning Objective: describe the incidence of pedal edema with calcium channel blockers and evaluate the withdrawal rate. JACC March 9, 2010 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids A51

1022-118 Atorvastatin Directly Reduces Vascular Superoxide 1072-88 Achieving Optimal Lipid Levels in Patients with Generation in Human Vein Grafts Ex Vivo, by Coronary Artery Disease in Clinical Practice Improving eNOS Coupling and Reducing NADPH- Raghunandan Dudda Subramanya, Scott E. Hessen, Longjan Oxidase Activity Liu, Mark F. Victor, Dean G. Karalis, Drexel University College of Constantinos Bakogiannis, Charalambos Antoniades, Dimitris Medicine, Philadelphia, PA, Cardiology Consultants of Philadelphia, Tousoulis, Michael Demosthenous, Alexios S. Antonopoulos, Philadelphia, PA Themistokles Psarros, George Ekonomopoulos, Nikolaos Sfyras, Learning Objective: evaluate whether pts with CAD achieve their Keith M. Channon, Christodoulos Stefanadis, 1st Cardiology recommended lipid goals in clinical practice. Department, Athens University Medical School, Athens, Greece, Department of Cardiovascular Medicine, University of Oxford, Impact of Adjunctive Cilostazol on Midterm Clinical Oxford, United Kingdom 1072-89 and Angiographic Outcomes in Patients Undergoing Learning Objective: This study demonstrates that atorvastatin Percutaneous Coronary Intervention with Drug exerts a direct effect on vascular redox both by improving eNOS Eluting Stent coupling and by reducing NADPH oxidase activity Kanhaiya L. Poddar, Seung Woon Rha, Sureshkumar Ramasamy, Ji 1022-119 Associations between High-sensitivity C-reactive Young Park, Lin Wang, Byoung Geol Choi, Cheol Ung Choi, Hong Euy Protein and the Risk of Developing Hypertension Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seo Seo, Dong Joo Oh, Korea University Guro Hospital, Seoul, South Korea Jang Hoon Lee, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Shung Chull Chae, Jae-Eun Jun, Wee-Hyun Park, Byung Yeol Chun, Learning Objective: Demonstrates equal efficacy of triple Sin Kam, Jung Gook Kim, In Kyu Lee, Bo Wan Kim, Daegu City antiplatelet therapy even in high risk PCI (with DES) group Hypertension-Diabetes Survey, Kyungpook National University Hospital, Daegu, South Korea 1072-90 Sustained Acting Atrial Natriuretic Peptide: A Hypertension, Prevention and Lipids Novel Therapeutic in a Canine Model of Acute Learning Objective: know baseline levels of hs-CRP are modestly Hypertension and Left Ventricular Dysfunction

associated with an increased risk of developing hypertension. General Cardiology: Induced by Angiotension II

Paul M. McKie, Alessandro Cataliotti, Guido Boerrigter, Fernando L. 1072 THE EFFECTS OF STATIN THERAPY ON Martin, S. Jeson Sangaralingham, John C. Burnett, Jr, Mayo Clinic, CORONARY DISEASE Rochester, MN Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Learning Objective: describe the blood pressure lowering and renal Georgia World Congress Center, Hall B5 enhancing properties of sustained acting atrial natriuretic peptide Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1073 ANTI-PLATELET AGENTS AND CORONARY ARTERY DISEASE 1072-86 What Are the Short and Long Term Benefits of Statin Therapy Initiated around the Time of Invasive Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Procedures?: A Meta-analysis of Randomized Georgia World Congress Center, Hall B5 Controlled Trials Presentation Hour: 3:30 p.m. - 4:30 p.m. David E. Winchester, Lola Xie, Anthony A. Bavry, University of Florida, CME/CE Hours: 1 Gainesville, FL 1073-92 Decreased Response To Clopidogrel Is A Risk Factor Learning Objective: Describe the short and long-term benefits of For Cardiovascular Events After Stent Implantation : statins started around the time of invasive procedures CROSS Verify Study 1072-87 Post-Hospital Discharge Treatment of Statin in Chi-hoon Kim, Kyung-Woo Park, Kihyun Jeon, Si-Hyck Kang, Kyung- Patients with Acute Myocardial Infarction: Is Statin Hee Kim, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Dae-Won Beneficial in Patient with LDL-cholesterol Lower Sohn, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim, Cardiovascular Than 70 mg/dL? center, Seoul National University Hospital, Seoul, South Korea

Hyun Kuk Kim, Myung Ho Jeong, Youngkeun Ahn, Jong Hyun Kim, Learning Objective: Understand characteristic PRU value related to Shung Chull Chae, Young Jo Kim, Seung Ho Hur, In Whan Seong, P2Y12 inhibition and non-responsiveness to clopidogrel in Asian Taek Jong Hong, Dong Hoon Choi, Myeong Chan Cho, Chong Jin (Korean) ethnicity. Kim, Ki Bae Seung, Wook Sung Chung, Yang Soo Jang, Seung Woon Rha, Jang Ho Bae, Jeong Gwan Cho, Seung Jung Park, The Heart 1073-93 Impact of Clopidogrel on Serum Anti-Xa Levels in Center of Chonnam National University Hospital, Gwangju, South Patients Receiving Enoxaparin Treatment Korea Solomon C. Yang, Shing Chiu Wong, Juey-Jen Hwang, National Learning Objective: identify the strategy of statin therapy Taiwan University Hospital, Taipei, Taiwan,ROC, New York Downtown Hospital, New York, NY Learning Objective: notice potential interaction between clopidogrel and enoxaparin A52 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids JACC March 9, 2010

1073-94 Effect of Ticagrelor versus Clopidogrel on High 1074-100 Relationship Between Lipoprotein(a), Homocysteine, Platelet Reactivity During Maintenance Therapy and C-Reactive Protein and Metabolic Syndrome in South Asian Patients Paul A. Gurbel, Kevin Bliden, Kathleen Butler, Cheryl Wei, Udaya S. Tantry, Sinai Center for Thrombosis Research, Baltimore, MD, Monica S. Divakaruni, Elena Flowers, Cesar Molina, Ashish Mathur, AstraZenacza LP, Wilmington, DE Megha Prasad, Leslie Abrams, Anita Sathe, Donna Malhotra, Ruby Basra, Gayatri Ratnam, Bradley E. Aouizerat, Mintu P. Turakhia, Learning Objective: To determine the The effect of Ticagrelor Stanford University, Department of Cardiovascular Medicine, compared to clopidogrel on high platelet reactivity during Stanford, CA, South Asian Heart Center, Mountian View, CA maintenance therapy Learning Objective: Describe the relationship between 1073-95 The Impact of Non-cytochrome 3a4 Metabolized Lipoprotein(a), homocysteine, and C-Reactive Protein and Metabolic Statin in Patients with High Post-clopidogrel Platelet Syndrome in South Asians Reactivity 1074-101 Renin-Angiotensin Blockade in the African-American Young-Hoon Jeong, In-Suk Kim, Yongwhi Park, Seok-Jae Hwang, Population Choong Hwan Kwak, Jin-Yong Hwang, Gyeongsang National University Hospital, Jinju, South Korea Eric M. Bader, Ronald Zolty, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, Montefiore Medical Center, Albert Learning Objective: enhance platelet inhibition and reduce the rate Einstein College of Medicine, Bronx, NY of HPPR through switch administration of non-CYP3A4 metabolized statin in HPPR patients receiving atorvastatin Learning Objective: understand the role of renin-angiotensin blockade in specific racial groups. 1073-96 Oxidative Stress is Associated with Reduced Glomerular Filtration Rate in a Population with 1074-102 Prognostic Implications of Atherogenic/Anti- Preserved Renal Function: the META-Health Study atherogenic Lipid Ratios in an Ethnically Diverse Population. Alanna Morris, Riyaz S. Patel, Liping Zhao, Yusuf Ahmed, Neli Stoyanova, Aurelian Bidulescu, Dorothy Coverson, Janice Lea, Viola Palaniappan Manickam, Ankit Rathod, Apurva Badheka, Vikas Vaccarino, Gary Gibbons, Dean P. Jones, Rebecca Din-Dzietham, Veeranna, Pawan Hari, Ashutosh Niraj, Sony Jacob, Luis Afonso, Arshed Quyyumi, Emory University School of Medicine, Atlanta, GA, Wayne State University, Detroit, MI Morehouse School of Medicine, Atlanta, GA Learning Objective: identify increased LDL-particle/HDL-particle Learning Objective: Oxidative Stress is Associated with Decreased concentration as a strong predictor of cardiovascular outcomes in eGFR in people with preserved renal function. asymptomatic healthy individuals. General Cardiology: General 1074 ETHNICITY AND ITS EFFECT ON LIPIDS 1075 SUB-CLASSES OF LIPOPROTEINS

Hypertension, Prevention and Lipids Hypertension, Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1

1074-98 Effect of Lipid Subclasses on the Risk of 1075-103 LDL Subfractions as Predictors of Angiographic Cardiovascular Outcomes in an Ethnically Diverse Coronary Artery Disease among those with Normal Asymptomatic Population and Abnormal LDL Levels

Ankit D. Rathod, Vikas Veeranna, Palaniappan Manickam, Apurva Heidi Thomas May, Krishnaji R. Kulkarni, Benjamin D. Horne, Jeffrey Badheka, Ashutosh Niraj, Jyotiranjan Pradhan, Sony Jacob, Luis L. Anderson, Tami L. Bair, Chrissa P. Mower, Joseph B. Muhlestein, Afonso, Wayne State Univeristy, Detroit, MI Intermountain Medical Center, Murray, UT, University of Utah, Salt Lake City, UT Learning Objective: Identify Lipid subclasses associated with adverse cardiovascular outcomes in asymptomatic patients. Learning Objective: Demonstrate that LDL subfractions may predict CAD risk, particularly among those with normal LDL levels. 1074-99 Clinical Outcomes Following Coronary Stenting in Japanese Patients with and without Proton Pump 1075-104 Lipoprotein (a) Levels Predict The Extent of Inhibitor Obstructive Disease and Longterm Cardiovascular Outcome in Patients Undergoing Coronary Hideki Shimomura, Seiji Hokimoto, Hisao Ogawa, The KICS Angiography with Suboptimal Lipid Contorol investigators, Fukuoka Tokusyukai Hospital, Kasuga, Japan, Kumamoto University, Kumamoto, Japan Stephen J. Nicholls, W.H.Wilson Tang, Danielle M. Brennan, Stanley L. Hazen, Cleveland Clinic, Cleveland, OH Learning Objective: describe the ability of Lp(a) as a predictor of cardiovascular event JACC March 9, 2010 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids A53

1075-105 Are Post-treatment Low Density Lipoprotein 1076-111 Diazoxide Choline Controlled Release in Subclass Pattern Analyses Potentially Misleading? Hypertriglyceridemic Subjects: Lipid and Other Metabolic Effects Harold E. Bays, Scott Conard, Lawrence A. Leiter, Steve Bird, Mary E. Hanson, Erin Jensen, Arvind Shah, Andrew M. Tershakovec, Merck Harold E. Bays, Eli M. Roth, Iain Dukes, Gloria Lin-Luo, Neil Cowen, & Co., Inc., North Wales, PA Yu Liu, Essentialis, Inc., Carlsbad, CA, Louisville Metabolic and Atherosclerosis Research Center Inc, Louisville, KY Learning Objective: Understand that there may be differences in and discuss the potential clinical implications of pre-treatment Learning Objective: descirbe DCCR effects on triglyceride lowering diagnostic vs post-treatment efficacy lipoprotein pattern analyses 1076-112 A Double Blind, Randomized, Multicenter, Parallel 1075-106 Associations between Lipoprotein Cholesterol Group, Placebo Control Trial to Evaluate the Effect Fractions and Measures of Platelet Aggregation in of Statin Therapy on Triglycerides Levels in Mexican Patients with Peripheral Arterial Disease Hypertriglyceridemic Patients

Salim S. Virani, Vijay Nambi, Husam Athamneh, Anirudh Kumar, Juan O. Talavera, Jose-Luis Cervantes, Javier A. Marin, Ignacio Angela L. Bergeron, Justin Saunders, Eric Yang, Carlos Bechara, Briones, Jose-Gerardo Gonzalez, Gustavo Martinez, Ana C. Polanco, Joel D. Morrisett, Changyi Chen, Peter H. Lin, Alan B. Lumsden, Hypertriglyceridemia Investigators Group, Instituto Mexicano del Jing-fei Dong, Christie M. Ballantyne, Baylor College of Medicine, Seguro Social, City, Mexico, Hospital Angeles del Pedregal, Houston, TX Mexico City, Mexico Learning Objective: Describe the associations between various lipid Learning Objective: To evaluate the efficacy of intensive statin parameters and measures of platelet reactivity to various agonists therapy in improving the lipid profile and associated cardiovascular in patients with peripheral arterial disease. risk factors Hypertension, Prevention and Lipids 1075-107 Discordance between Traditional Lipid parameters, 1076-113 Optimal Plasma Low-Density Lipoprotein Apolipoproteins and Lipoprotein particle number: Cholesterol but Abnormal Triglycerides: Is it Also a

Insights from the Atherosclerosis Risk In Risk Profile for Cardiovascular Mortality? General Cardiology: Communities (ARIC) Carotid MRI Study Elena V. Kuklina, Nora L. Keenan, William M. Callaghan, Yuling Salim S. Virani, Diane J. Catellier, Vijay Nambi, Ron C. Hoogeveen, Hong, CDC, Atlanta, GA Bruce A. Wasserman, Josef Coresh, Thomas H. Mosley, James D. Otvos, A. Richey Sharrett, Eric Boerwinkle, Christie M. Ballantyne, Learning Objective: To describe the associations between “optimal Baylor College of Medicine, Houston, TX low-density lipoprotein cholesterol / abnormal triglycerides” lipid profile and cardiovascular mortality in the large nationally Learning Objective: Describe the degree of discordance between representative study. traditional cholesterol measures and newer lipoprotein measures in an ethnically diverse epidemiologic cohort. 1077 MARKERS OF INFLAMMATION AND ATHEROSCLEROSIS 1076 TREATMENT OF HYPERTRIGLYCERIDEMIA Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1 1077-115 Inverse Relationship Between HDL-C Raising and 1076-109 Optimal Pharmacological Approach to hsCRP Reduction in Older Patients Treated with Hypertriglyceridemia Combined with Low HDL- Lipid-Lowering Therapy Cholesterol: Effects of Fenofibrate 160 mg vs Niacin 1500 mg on Apolipoprotein B/A1 Ratio, Lipid William V. Brown, JoAnne M. Foody, Franklin Zieve, Charlotte Jones- Profile, Glucose Metabolism, and Inflammation Burton, Qian Dong, Joanne E. Tomassini, Arvind Shah, Andrew M. Tershakovec, Merck & Co., Inc., North Wales, PA Jin Wi, Sang-Hak Lee, Young-Guk Ko, Seok-Min Kang, Donghoon Choi, Jong-Won Ha, Myeong-Ki Hong, Yangsoo Jang, Namsik Chung, Learning Objective: Describe the relationships between hsCRP, Won-Heum Shim, Seung-Yun Cho, Division of Cardiology, Yonsei LDL-C, non-HDL-C and ApoB in older patients with moderate/high University Severance Hospital, Seoul, South Korea cardiovascular disease risk following treatment with ezetimibe/ simvastatin and atorvastatin Learning Objective: make optimal pharmacological approach to hypertriglyceridemia combined with low HDL-cholesterol 1077-116 Efficacy of Rosuvastatin in Primary Prevention According to Baseline Levels of hsCRP in the 1076-110 Efficacy and Safety of Fenofibrate 160 mg in JUPITER Trial Combination with Pravastatin 40 mg in Type 2 Diabetic Patients with Combined Hyperlipidemia Paul M. Ridker, Robert J. Glynn, on behalf of the JUPITER and without Cardiovascular Disease Investigators, Brigham and Women’s Hospital, Boston, MA Learning Objective: understand the effectiveness of rosuvastaitn in Michel Farnier, Armin Steinmetz, Kjetil Retterstol, Miroslaw the JUPITER trial according to entry levels of both hsCRP and LDLC. Dluzniewski, Albert Csazar, Point Medical, Dijon, France Learning Objective: treat dyslipidemia of type 2 diabetic patients A54 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids JACC March 9, 2010

1077-117 Efficacy of Rosuvastatin Among Men and Women 1127-88 Extended-Release Niacin/Laropiprant Lowers with Chronic Kidney Disease and Elevated hsCRP: Serum Phosphorus Concentrations in Dyslipidemic The JUPITER Trial Patients

Paul M. Ridker, Robert J. Glynn, on behalf of the JUPITER Andrew G. Bostom, Darbie Maccubbin, Diane Tipping, Olga Investigators, Brigham and Women’s Hospital, Boston, MA Kuznetsova, William A. Hanlon, Rhode Island Hospital, Providence, RI, Merck & Co., Inc., Whitehouse Station, NJ Learning Objective: to understand the effectiveness of rosuvastatin in primary prevention among men and women with low LDLC, Learning Objective: Understand the phosphorus-lowering elevatd hsCRP, and concomitant evidence of chronic kidney disease. capability of extended release niacin and its potential relevance to cardiovascular disease prevention. 1077-118 Quinapril and Lipoic Acid Improve Endothelial Function and Reduce Markers of Inflammation: 1127-89 Effects of Nebivolol on Levels of Markers of Results of Quinapril and Lipoic Acid in the Inflammation and Obesity in Response to Exercise- Metabolic Syndrome (QUALITY) study induced Stress: Studies in Obese African-american Patients with Stage I Hypertension Bobby V. Khan, Syed T. Rahman, Tahir Haque, Nadya Merchant, Atlanta Vascular Research Foundation, Atlanta, GA, Emory University Nadya Merchant, Syed T. Rahman, Keith C. Ferdinand, Guillermo E. School of Medicine, Atlanta, GA Umpierrez, Bobby V. Khan, Emory University, Division of Cardiology, Atlanta, GA, Atlanta Vascular Research Foundation, Atlanta, GA Learning Objective: identify treatment of the metabolic syndrome Learning Objective: Understand that the effects of nebivolol are 1077-119 Omega-3 Index: Relationship with Classic and not limited to hypertension, but this beta-blocker is also beneficial Emerging Coronary Heart Disease Risk Factors with regards to inflammation and obesity, specifically in the obese African-American Mohammad Abuannadi, James H. O’Keefe, John A. Spertus, Kevin F. Kennedy, Krishnaji Kulkarni, William S. Harris, Mid America Heart 1127-90 Valproate Attenuates the Risk of Myocardial Institute/University of Missouri-Kansas City, Kansas City, MO, Infarction in Patients with Epilepsy: A Nationwide Cardiovascular Health Research Center, Sanford Research/USD and Cohort Study Sanford School of Medicine, Sioux Falls, SD Jonas B. Olesen, Peter R. Hansen, Steen Z. Abildstrøm, Charlotte Learning Objective: identify the relationship of omega-3 index with Andersson, Peter Weeke, Michelle Schmiegelow, Jesper Erdal, lipid and inflammatory risk markers Christian Torp-Pedersen, Gunnar H. Gislason, Gentofte University Hospital, Copenhagen, Denmark 1127 CLINICAL TRIALS AND INTERVENTIONAL

General Cardiology: General Learning Objective: consider the potential benefit of valproate on THERAPIES the risk of myocardial infarction in the treatment of epilepsy Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Hypertension, Prevention and Lipids Hypertension, Georgia World Congress Center, Hall B5 1128 EPIDEMIOLOGY Presentation Hour: 9:30 a.m. - 10:30 a.m. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. CME/CE Hours: 1 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. 1127-86 Impact of Cardiac Rehabilitation on Mortality and Cardiovascular Events after Percutaneous Coronary CME/CE Hours: 1 Intervention 1128-92 The American Association of Cardiovascular Kashish Goel, Ryan J. Lennon, R. T. Tilbury, Ray W. Squires, Randal and Pulmonary Rehabilitation (AACVPR) Risk J. Thomas, Mayo Clinic, Rochester, MN Classification Identifies Coronary Heart Disease Learning Objective: Identify the impact of cardiac rehabilitation on Patients Who Are at Increased Risk of Death outcomes after percutaneous coronary intervention Todd M. Brown, Bonnie K. Sanderson, Vera Bittner, University of Alabama at Birmingham, Birmingham, AL, Auburn University, 1127-87 Usefulness of Anticoagulant Therapy for Atrial Auburn, AL Fibrillation in Chronic Kidney Disease Patients after Percutaneous Coronary Intervention with Stenting Learning Objective: Evaluate the ability of the AACVPR Cardiac Rehabilitation Risk Classification to predict mortality in CAD Yusuke Iwasaki, Takahisa Yamada, Yuji Okuyama, Takashi Morita, patients. Yoshio Furukawa, Koji Tanaka, Taku Yasui, Hiromichi Ueda, Takeshi Okada, Masato Kawasaki, Yuki Kuramoto, Masatake Fukunami, 1128-93 Association of Renal-Related Biomarkers with All- Osaka General Medical Center, Osaka, Japan Cause and Cause-Specific Mortality in Subjects with Learning Objective: Anticoagulant therapy in CKD patients with AF Different Framingham Risks after PCI with stenting. Jou-Wei Lin, Cho-Kai Wu, Yu-Sheng Lin, Dept of Environmental and Occupational Health, Univ of North Texas Health, Fort Worth, TX Learning Objective: Cystatin C is predictive of CV mortality on top of Framingham risks. JACC March 9, 2010 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids A55

1128-94 Psoriasis is a Risk Factor for Atrial Fibrillation and 1129-100 Impact of Telemedicine System on CVD Risk Stroke: A Danish Nationwide Cohort Study Reduction and Adoption of Healthy Life Behaviors Ole Ahlehoff, Gunnar H. Gislason, Jesper Lindhardsen, Casper H. Jorgensen, Mette G. Charlot, Steen Z. Abildstrom, Lone Skov, Mohamad Alkhouli, Carol J Homko, Abdul Kashem, William P Christian Torp-Pedersen, Peter R. Hansen, Department of Cardiology, Santimore, Nabeel Memon, Jorge Gonzalez, Linda Zamora, Copenhagen University Hospital Gentofte, Hellerup, Denmark Timothy R McConnell, Alfed A Bove, Temple University Hospital, Philadelphia, PA Learning Objective: Identify psoriasis as a risk factor for atrial fibrillation and stroke Learning Objective: Recognize Telemedicine as an important tool in risk reduction in patient with CVD risk factors 1128-95 Hyperhomocysteinemia ; Another Risk Factor Associated With Contrast Media Induced 1129-101 The Comparable Effect of Lifestyle and Nephropathy Pharmacological Intervention to Prevent Coronary Atherosclerosis in Japanese Early-stage Diabetic Hyuck Yoon, Hong-won Shin, Ji-hyun Son, Hyoung-Seob Park, Yun- Patients - The DIAbetes and diffuse coronary Kyeong Cho, Chunduk Han, Hyungseop Kim, Chang-Wook Nam, Seung-Ho Hur, Yoon-Nyun Kim, Kwon-Bae Kim, Division of Cardiology, Narrowing (DIANA) study Keimyung University Dongsan Hospital, Daegu, South Korea Yu Kataoka, Satoshi Yasuda, Yoshihiro Miyamoto, Kazuhiro Sase, Learning Objective: identify Masami Kosuge, Kazuo Kimura, Yasunao Yoshimasa, Shunichi Miyazaki, National Cardiovascular Center, Osaka, Japan 1128-96 Apolipoprotein A1 Predicts Future Death and Myocardial Infarction in Patients Undergoing 1129-102 Whole Body Periodic Acceleration Improves Coronary Angiography Hypertension, Prevention and Lipids Coronary Microcirculation in Healthy Subjects and Heidi Thomas May, Krishnaji R. Kulkarni, Benjamin D. Horne, Jeffrey Patients with Coronary Artery Disease L. Anderson, Tami L. Bair, Chrissa P. Mower, John F. Carlquist, Kono Yasushi, Shota Fukuda, Kenei Shimada, Toshihiro Kawasaki, General Cardiology: Joseph B. Muhlestein, Intermountain Medical Center, Murray, UT, Satoshi Jissho, Haruyuki Taguchi, Kumiko Maeda, Minoru University of Utah, Salt Lake City, UT Yoshiyama, Masatoshi Fujita, Junichi Yoshikawa, Department of Learning Objective: Demonstrate that apolipoprotein A1 predicts Medicine, Osaka Ekisaikai Hospital, Osaka, Japan, Department of short and long-term risk, even among those with normal HDL levels. Internal Medicine and Cardiology, Osaka City University School of Medicine, Osaka, Japan 1129 LIFE STYLE MODIFICATIONS AND PHYSICAL ACTIVITY 1130 GENDER DIFFERENCES IN CARDIOVASCULAR Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. MEDICINE Georgia World Congress Center, Hall B5 Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. Georgia World Congress Center, Hall B5 CME/CE Hours: 1 Presentation Hour: 9:30 a.m. - 10:30 a.m. 1129-98 Consumption of Alcohol, Particularly Wine, is CME/CE Hours: 1 Negatively Associated With Carotid Intima Media Thickness, and is in Part due to Familial Factors 1130-103 Effect Of Oral Vs. Patch Contraception On Inflammatory Markers, Oxidative Stress, And Amit J. Shah, Emir Veledar, Jack Goldberg, Douglas Bremner, Viola Vascular Reactivity In Healthy Pre-Menopausal Vaccarino, Emory University, Atlanta, GA, University of Washington, Women Seattle, WA Pathmaja Paramsothy, Eric V. Kreiger, Elizabeth Chan, Eve Preus, Learning Objective: Evaluate the association between alcohol Irina Rusanu, Sarah Prager, Brian Fish, Robert H. Knopp, University consumption and carotid intima media thickness while controlling of Washington, Seattle, WA, Harborview Medical Center, Seattle, WA for familial and cardiovascular risk factors Learning Objective: Demonstrate the effects of oral vs. patch 1129-99 Behavioral Comparison Between Rural And Urban hormone contraception on markers of inflammation and oxidative Populations In Cardiovascular Disease Risk stress and on endothelial function as measured by brachial artery Reduction reactivity.

Mohamad Alkhouli, Carol F Homko, Memon Nabeel, abdul Kashem, 1130-104 Women Receive Smaller Aortic Valve Prosthes Than Alfred A Bove, Temple University Hospital, Philadelphia, PA Men - For Anatomical Reasons?

Learning Objective: Learn about differences between rural and Christina Fuchs, Elisabeth Pernicka, Gerald Maurer, Helmut urban indivisuals participation in CVD risk reduction Baumgartner, Julia Mascherbauer, Medical university of Vienna, Vienna, Austria Learning Objective: demonstrating gender specific differences in aortic valve replacement A56 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids JACC March 9, 2010

1130-105 Treatment Strategy and Long-term Mortality in 1131-111 Older Is Wiser: Low-Density Lipoprotein Cholesterol Female Patients with Non-ST-Elevation Acute Goal Attainment in a Multinational Survey Coronary Syndrome; a Substudy from the ICTUS of Dyslipidemic Patients: A Lipid Treatment Trial Assessment Project (L-TAP) 2 Substudy

Peter Damman, Fons Windhausen, Alexander Hirsch, Jan GP Tijssen, Raul D. Santos, David D. Waters, Jean Ferrieres, J-Wouter Jukema, Robbert J. de Winter, Academical Medical Center, Amsterdam, The Cheng-Wen Chiang, Michael Messig, Lisa Tarasenko, for the L-TAP Netherlands 2 Investigators, Lipid Clinic Heart Institute (InCor) University of Sao Paulo, Sao Paulo, Brazil, Division of Cardiology, San Francisco Learning Objective: Describe 5-year mortality in women with nSTE- General Hospital and University of California, San Francisco, CA ACS and elevated troponin T after early invasive versus selective invasive strategy Learning Objective: Compare differences in risk factors and lipid control between younger and older individuals enrolled in the 1130-106 Lack of Effect of Thiazide Diuretics on Bone Mineral multinational LTAP-2 study Density in Hypertensive Elderly African American Women 1131-112 Statin Therapy after Coronary Artery Bypass Graft Surgery Is Associated with Reduced All-cause Fahad Javed, Emad F. Aziz, Alexandre M. Benjo, Ramya Suryadevara, Mortality. Carlos Alviar, Jorge Romero, Iffat Shaheen, Eyal Herzog, Franz Messerli, St..Lukes-Roosevelt Hospital Center,Columbia College of Femi Philip, Cleveland Clinic Foundation, Cleveland, OH Physicians & Surgeons, New York, NY Learning Objective: Understand the value of statin therapy after Learning Objective: Evaluate the effects of thiazide diuretics on the coronary artery bypass graft surgery bone density of African American post menopausal women 1131-113 Low-Dose Acetylsalicylic Acid-Associated Peptic 1130-107 Prognostic Role of N-terminal pro-Brain Natriuretic Ulcers and Dyspeptic Symptoms are Reduced by Peptide in a Population at High Risk for Esomeprazole 20 mg and 40 mg Once Daily Cardiovascular Disease. James Scheiman, Johan Herlitz, Philip Devereaux, Emma Naucler, Irene Betti, Piercarlo Ballo, Alessandro Barchielli, Alfredo Zuppiroli, Lars-Erik Svedberg, University of Michigan Hospitals, Ann Arbor, MI Unità Operativa di Cardiologia, Ospedale S. Maria Annunziata, Learning Objective: evaluate the clinical benefit of esomeprazole Azienda Sanitaria di Firenze, Firenze, Italy treatment in patients who require low-dose ASA (75–100 mg) Learning Objective: Evaluate the predictive value of NT-pro BNP for cardiovascular risk management and are at risk of upper in a large cohort of subjects with hypertension and diabetes from gastrointestinal adverse events.

General Cardiology: General primary care

1132 METABOLIC SYNDROME, DIABETES AND 1131 PHARMACOLOGIC THERAPY

Hypertension, Prevention and Lipids Hypertension, LIFESTYLE Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1131-109 Role of Statin Therapy in Primary Prevention of 1132-115 Achievement of Dietetic and Exercise Therapy Heart Failure Evaluated by Self assessment Score Significantly Jorge E. Silva Enciso, Harikrishna Makani, Jorge Romero, Emad Improved Endothelial Dysfunction in Patients with Aziz, Marrick Kukin, Franz Messerli, St. Luke’s Roosevelt Hospital Metabolic Syndrome and Columbia University College of Physicians and Surgeons, New yasushi matsuzawa, Seigo Sugiyama, Kazuo Kimura, Hisao Ogawa, York, NY Department of Cardiovascular Medicine, Graduate School of Learning Objective: evaluate the benefits of statins in preventing or Medical Sciences, Kumamoto University, Kumamoto, Japan, Division treating heart failure. of Cardiology, Yokohama City University Medical Center, Yokohama, Japan 1131-110 Cardiovascular Event Rates in Stable Coronary Learning Objective: This study demonstrated the usefulness of the Patients With Chronic Kidney Disease, Increased By self assessment scoring system to evaluate efficacy of the life style the Presence of Obesity, are Reduced by Intensive intervention on achieving cardiovascular benefits. Lipid Lowering With Atorvastatin

Prakash C. Deedwania, James Shepherd, Daniel J. Wilson, on behalf of the TNT Investigators, VACCHCS/UCSF School of Medicine, Fresno, CA, University of Glasgow, Glasgow, United Kingdom Learning Objective: Describe the association of obesity with CKD and impact of lipid lowering therapy with atorvastatin JACC March 9, 2010 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids A57

1132-116 Changes in Plasma Glucagon-like Peptide-1 Levels 1182-87 Socioeconomic status and cardiovascular disease during Oral Glucose Tolerance Test Reflect Impaired mortality in Thailand: the Electricity Generating Glucose Tolerance in Non-diabetic Subjects Authority of Thailand Study

Fumiyuki Otsuka, Masami Kosuge, Kiyoshi Hibi, Naohiro Komura, Prin Vathesatogkit, Sukit Yamwong, Mark Woodward, David Batty, Nobuhiko Maejima, Tatsuya Nakachi, Katsutaka Hashiba, Naoki Federica Barzi, Sayan Cheepudomwit, Sarana Boonbaichaiyapruck, Nakayama, Masayoshi Kiyokuni, Noriaki Iwahashi, Jun Okuda, Supachai Tanomsup, Nongnuj Unkurapinun, Piyamitr Sritara, Mahidol Kengo Tsukahara, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura, University, Bangkok, Thailand, The George Institute for International Division of Cardiology, Yokohama City University Medical Center, Health, Sydney, Australia Yokohama, Japan Learning Objective: see the important of socioeconomic disparity, Learning Objective: demonstrate that incretin action as assessed this data is new in ASIAN population. by plasma glucagon-like peptide-1 level is reduced even in subjects with impaired glucose tolerance, the pre-stage of diabetes. 1182-88 Impact of Gender and Ethnicity on Adherence to Guideline Recommended Aspirin Therapy. 1132-117 Adherence to the Mediterranean Diet Is Associated with Renal Function among Healthy Adults: The Joji J. Varghese, Catherine McNeal, Juhee Song, Dean Kjar, Mazi Attica Study Mahjoobi, MaryAnn Morgan-Cox, John P. Erwin, Scott and White Hospital, Texas A&M University, Temple, TX Christina A. Chrysohoou, Demosthenes B. Panagiotakos, Christos Learning Objective: To identify the factors associated with non-use Pitsavos, John Skoumas, Akis Zeibekis, Christina Kastorini, of aspirin in the recommended population. Constantina Masoura, Efi Tsetsekou, Manolis Kambaxis, Nina Papaioannou, Vasiliki Metaxa, Christodoulos Stefanadis, 1st The Impact of Replacing Hard Cardiac Risk with Cardiology Clinic, Hippokratio, Athens, Greece, Harrokopio 1182-89 University, Athens, Greece Global Cardiovascular Risk Scores in the Older Hypertension, Prevention and Lipids Adults Learning Objective: Greater adherence to the Mediterranean diet Matthew Tattersall, Kunal N. Karmali, Jon G. Keevil, University of

is independently associated with reduced urea, creatinine and General Cardiology: increased Ccr rates among healthy men and women. Wisconsin School of Medicine and Public Health, Madison, WI Learning Objective: Interpret the National implications of utilizing 1132-118 Divergent Effects of Smoking Intensity on global cardiovascular risk assessment Inflammatory Markers in a Large Cohort of Active Smokers 1182-90 Association of Neighborhood Socioeconomic Status Asha Asthana, Heather M. Johnson, Megan E. Piper, Michael C. with C-reactive Protein and All-Cause Mortality: the Fiore, Timothy B. Baker, James H. Stein, University of Wisconsin REGARDS Study School of Medicine and Public Health, Madison, WI Mehdi H. Shishehbor, Suzanne Judd, David Litaker, Saima Karim, Learning Objective: Describe the relationships between hsCRP, WBC Dawn Kleindorfer, Michael Lauer, George Howard, Virginia Howard, count, and markers of smoking intensity. Mary Cushman, Cleveland Clinic, Cleveland, OH, University of Alabama, Birmingham, AL 1132-119 Combined Effect of Physical Inactivity and Learning Objective: Describe the association between neighborhood Depression as Predictors of Mortality: The of residence, hs-CRP, and all-cause mortality. Cardiovascular Health Study

Sithu Win, Kapil Parakh, Chete Eze-Nliam, Willem J. Kop, Roy C. 1183 INSULIN RESISTANCE, DIABETES AND Ziegelstein, Johns Hopkins Medical Institutions, Baltimore, MD, METABOLIC SYNDROME University of Maryland, Baltimore, MD Learning Objective: identify the prognostic importance of depression Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. and physical inactivity among individuals older than 65 years of age. Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1182 GENDER, AGE AND SOCIOECONOMIC STATUS Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. 1183-92 Association of Insulin Resistance with Preclinical Georgia World Congress Center, Hall B5 Cardiovascular Disease in Adolescents and Young Presentation Hour: 3:30 p.m. - 4:30 p.m. Adults: The Strong Heart Study. CME/CE Hours: 1 Marina De Marco, Giovanni de Simone, Mary J. Roman, Marcello Chinali, Marie Russell, Elisa T. Lee, Barbara V. Howard, Richard B. 1182-86 Gender and Ethnic Differences in Cardiovascular Devereux, Federico II University, Napoli Events and Mortality in Patients with Depressive Learning Objective: Identify factors associated to insulin resistance Symptoms in adolescents and young adults Pawan K. Hari, Vikas Veeranna, Rajeev Sudhakar, Palaniappan Manickam, Ashutosh Niraj, Ramanjit Kaur, Sony Jacob, Luis Afonso, Wayne State University, Detroit, MI Learning Objective: identify that depression is associated with incident cardiovascular events, stroke, and all cause mortality in healthy adult US females regardless of ethnic background A58 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids JACC March 9, 2010

1183-93 Absolute Glucose Changes With Lifestyle 1184-99 Prevalence, Diagnosis, and Treatment of Impaired Modification in Impaired Glucose Tolerance Fasting Glucose and Impaired Glucose Tolerance

Elisa Bradley, Leonelo Bautista, Patrick McBride, The University of Amrita M. Karve, Rodney Hayward, University of Michigan, Ann Wisconsin, Madison, WI Arbor, MI Learning Objective: identify expected glucose changes after lifestyle Learning Objective: Understand the rates of prevalence, diagnosis, modification in patients with impaired glucose tolerance. and treatment of prediabetes in the American adult population

1183-94 Metabolic Phenotypes And Cardiovascular 1184-100 High Prevalence of Obesity and Metabolic Abnormalities In Prediabetes Syndrome in Women and Association with Insurance Status Giovanni de Simone, Brunella Capaldo, Mary J. Roman, Olga Vaccaro, Michele Iaccarino, Elisa T. Lee, Hong Wang, Barbara V. Leonidas V. Athanasopoulos, Caitlin E. Johnson, Jennifer L. Jarvie, Howard, Richard B. Devereux, Federico II University, Naples, Italy, Farhan Aslam, Joanne M. Foody, Brigham & Women’s Hospital, Weill-Cornell Medical College, New York, NY Boston, MA Learning Objective: Evaluate potential CV risk associated with Learning Objective: To evaluate the prevalence of obesity and prediabetes status in relation to the type of abnormality of metabolic syndrome in women and their relationship to insurance glucose regulation status

1183-95 Improvement Of Metabolic Syndrome With Low 1184-101 Refined Carbohydrates, Relatively High Protein Diet Increased Cardiovascular Event Rate Observed in Stable Enriched With Mono-and Poly-unsaturated Fatty Coronary Patients with Metabolic Syndrome Complicated Acids by Chronic Kidney Disease Is Reduced by Intensive Lipid Lowering with Atorvastatin Francisco Lopez-Jimenez, Ling Xu, Kim L. Edens, Mayo Clinic, Rochester, MN Prakash C. Deedwania, James Shepherd, Daniel J. Wilson, on behalf Learning Objective: A low refined carbohydrates, relatively high of the TNT Investigators, VACCHCS/UCSF School of Medicine, protein diet enriched with mono- and poly-unsaturated fatty acids Fresno, CA, University of Glasgow, Glasgow, United Kingdom would improve metabolic syndrome. Learning Objective: Evaluate the effect of intensive lipid lowering 1183-96 Insulin Resistance is Associated with Metabolic on the increased cardiovascular risk observed in stable coronary Syndrome But Not With Angiographically patients with metabolic syndrome complicated by chronic kidney disease General Cardiology: General Determined Coronary Artery Disease

Alexander Vonbank, Philipp Rein, Christoph H. Saely, Stephan Beer, 1184-102 Comparison Of Anthropometric Indices In Predicting Johannes Breuss, Heinz Drexel, VIVIT Institut, Feldkirch, Austria Metabolic Syndrome Components In Children Hypertension, Prevention and Lipids Hypertension, Learning Objective: Insulin resistance is not significantly associated Mehmet A. Agirbasli, Nihat Bugra Agaoglu, Marmara University, with angiographically coronary artherosclerosis Istanbul, Turkey, Uskudar Municipality, Istanbul, Turkey Learning Objective: To understand the association of anthropometric 1184 INSULIN RESISTANCE, DIABETES AND indices with metabolic syndrome components in children METABOLIC SYNDROME Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. 1185 DIAGNOSTIC APPROACHES AND METHODS Georgia World Congress Center, Hall B5 Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 CME/CE Hours: 1 Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1184-98 Effects Of Low Fat Vs. Moderate Fat Diet On Insulin Resistance And Endothelial Function In Metabolic Detection of Subclinical Atherosclerosis by Office- Syndrome 1185-103 Based Carotid Ultrasound Increases Prescription of Pathmaja Paramsothy, Arthi Thirumalai, Alice Dowdy, Brian Fish, Preventive Therapies Robert H. Knopp, University of Washington, Seattle, WA, Harborview Medical Center, Seattle, WA Heather Johnson, Terry L. Turke, Mark Grossklaus, Tara Dall, Sanford Carimi, Laura M. Koenig, Susan E. Aeschlimann, Claudia E. Learning Objective: To identify the differences of a low fat vs. Korcarz, James H. Stein, University of Wisconsin School of Medicine moderate fat diet on insulin resistance and endothelial function in and Public Health, Madison, WI Metabolic Syndrome Learning Objective: Describe the use of carotid ultrasound screening by primary care providers to improve cardiovascular risk prediction and management JACC March 9, 2010 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids A59

1185-104 Effects of Office-Based Carotid Ultrasound on 1186-111 Supplementing Deficient Vitamin D Levels is Health-Related Behaviors and Perceptions of Associated with Reduced Cardiovascular Risk Cardiovascular Disease Risk in Patients Tami Bair, Joseph B. Muhlestein, Heidi T. May, Benjamin D. Heather Johnson, Terry L. Turke, Mark Grossklaus, Tara Dall, Horne, John F. Carlquist, Donald L. Lappé, Jeffrey L. Anderson, Sanford Carimi, Laura M. Koenig, Susan E. Aeschlimann, Claudia E. Intermountain Medical Center, Murray, UT Korcarz, James H. Stein, University of Wisconsin School of Medicine Learning Objective: Evaluate whether increasing Vitamin D levels and Public Health, Madison, WI will decrease cardiovascular risk. Learning Objective: Describe the effects of carotid ultrasound screening on patient health-related behaviors and perception of 1186-112 Vitamin D Deficiency Highly Prevalent among Post- cardiovascular risk MI Patients

John H. Lee, John A. Spertus, Paul Chan, Fengming Tang, James H. 1185-105 High Sensitivity Troponin T Levels in Obstructive Sleep Apnea O’Keefe, Mid America Heart Institute, University of Missouri-Kansas City, Kansas City, MO, Ochsner Clinic Foundation, New Orleans, LA Anna Randby, Silje K Namtvedt, Gunnar Einvik, Tor-Arne Hagve, Learning Objective: Realize the high prevalence of vitamin D Virend K Somers, Torbjorn Omland, Akershus University Hospital, deficieny in acute myocardial infarction patients. Lorenskog, Norway Learning Objective: interpret high sensitivity cardiac troponin T test results in patients with OSA. 1187 PHYSICAL ACTIVITY AND EXERCISE THERAPY Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. A Screening Glance to Abdominal Aorta and to 1185-106 Georgia World Congress Center, Hall B5

Carotids During Transthoracic Echocardiography : A Hypertension, Prevention and Lipids Presentation Hour: 3:30 p.m. - 4:30 p.m. Real World prospective monocentre observational Study CME/CE Hours: 1 General Cardiology: Stalder Nicolas, JAUSSI ANDRES, CHUV, Lausanne, Switzerland 1187-115 Physical Activity, Metabolic Syndrome and Coronary Learning Objective: distinguish Risk; The Epic-Norfolk Prospective Population Study Lysette N. Broekhuizen, Matthijs S. Boekholdt, Benoit J. Arsenault, 1185-107 Oxidative Stress and Inflammatory Biomarkers Jean-Pierre Despres, Erik S.G. Stroes, John J.P. Kastelein, Nicholas in Pre-hypertensive and Normotensive African J. Wareham, Kay-Tee Khaw, Department of Vascular Medicine, Americans Academic Medical Centre., Amsterdam, The Netherlands, Institute of Public Health and Primary Care, University of Cambridge, Keith M. Diaz, Deborah L. Feairheller, Kathleen M. Sturgeon, Sheara Cambridge, United Kingdom Williamson, Praveen Veerabhadrappa, Deborah Crabbe, Michael D. Brown, Temple University, Philadelphia, PA Learning Objective: describe that active participants with MS have a less severe form of MS and a lower risk for CHD than participants Learning Objective: describe the difference in oxidative stress who are inactive and inflammatory biomarkers between pre-hypertensive and normotensive African Americans 1187-116 Cardiopulmonary Fitness is Associated with Lower Cardiovascular Mortality in A Community-based 1186 PRIMARY PREVENTION, VITAMINS AND Cohort ANTIOXIDANTS Abhijeet Dhoble, Brian Lahr, Thomas G. Allison, Iftikhar Kullo, Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Francisco Lopez-Jimenez, Ray W. Squires, Gerald Gau, Randal J. Thomas, Stephen L. Kopecky, Mayo Clinic, Rochester, MN Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: Cardiopulmonary fitness reduces cardiovascular mortality by more than 50%, even in patients with traditional risk CME/CE Hours: 1 factors. Do Antioxidant Vitamins Ameliorate the Beneficial 1186-109 Relationship Between Changes in Heart Rate Effects of Exercise Training on Insulin Sensitivity? 1187-117 Recovery after Cardiac Rehabilitation on Carl J. Lavie, Jr., Jenna N. Milani, Ochsner Health System, New Cardiovascular Mortality in Patients with Myocardial Orleans, LA Infarction

Learning Objective: Describe the effects of exercise following Siu Han Jo Jo Hai, Pak-Hei Chan, Kelvin Chan, Simon Lam, Chung- cardiac rehabilitation on measures of insulin sensitivity Wah Siu, Hee-Hwa Ho, Sheung-Wai Li, Hon-Wah Chan, Stephen Lee, Hung-Fat Tse, Queen Mary Hospital, Pokfulam, Hong Kong Stratifying Cardiovascular Risk by Vitamin D Levels: 1186-110 Learning Objective: Identify that heart rate recovery improves with What Are the Optimal Cutoffs? exercise training and that modified heart rate recovery predicts Heidi Thomas May, Jeffrey L. Anderson, Donald L. Lappé, Benjamin cardiac death in patients with prior myocardial infarction D. Horne, Tami L. Bair, Joseph B. Muhlestein, Intermountain Medical Center, Murray, UT Learning Objective: Identify the risk associated with different Vitamin D levels. A60 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids JACC March 9, 2010

1187-118 Subjective Rather Than Physical Improvements 1237-89 Arterial and Venous Endothelial Dysfunction in Mediate the Reduction in Depression Associated Resistant Hypertensive Patients With Participation in a Cardiac Rehabilitation Juan Carlos Yugar-Toledo, Leoni A. Souza, Samira U. Girioli, Luiz Program in Women C. Martins, Leandro B. Martins, José F. Vilela-Martin, Cláudia Donna Chelle V. Morales, Beth Parker, Marie LaGasse, Edward M. Irigoyen, Heitor Moreno Jr., Pharmacology Department State Dostaler, Donna Polk, Hartford Hospital, Hartford, CT, University of University of Campinas, Campinas, Brazil Connecticut, Internal Medicine Residency, Farmington, CT Learning Objective: to evaluate endothelial-dependent and Learning Objective: Identify which factors affect reduction in -independent venous and arterial vasodilation in optimized RH depression with cardiac rehabilitation in women. patients compared to well-controlled hypertensive (CH) patients and normotensive individuals 1187-119 Exercise Training Relieves Palpitation And Premature Ventricular Depolarizations Through 1237-90 Coronary microcirculation Dysfunction is Decrease In Peri-infarct Zone Accompanied by an Impairment of Left Ventricular Diastolic Properties in Male Hypertensives Bai-Chin Lee, Ming-Fong Chen, Wen-Yih I. Tseng, Ssu-Yuan Chen, National Taiwan University Hospital, Taipei, Taiwan,ROC Dimitris Tsiachris, Konstantinos Tsioufis, Dimitris Roussos, Kyriakos Dimitriadis, Kostas Toutouzas, Eleftherios Tsiamis, Learning Objective: iidentify the role of periinfarct zone in postinfarct Dimitris Tousoulis, Christodoulos Stefanadis, First Cardiology Clinic, patients University of Athens, Hippokration Hospital, Athens, Greece Learning Objective: demonstrate the parallel abnormalities of coronary 1237 HYPERTENSION AND THE ARTERY WALL blood flow reserve and diastolic function in male hypertensives, as well as their relationship with increased pulsatile load Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. 1238 HYPERTENSION AND EFFECTS ON CIRCULATING CME/CE Hours: 1 FACTORS Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. The Adverse Effects of Nocturnal Hypertension on 1237-86 Georgia World Congress Center, Hall B5 Arterial Stiffness and Urinary Albumin Excretion in Presentation Hour: 9:30 a.m. - 10:30 a.m. Hypertension CME/CE Hours: 1 Dimitris Syrseloudis, Konstantinos Tsioufis, Eirini Andrikou, Ioannis General Cardiology: General Andrikou, Anastasia Mazaraki, Elli Stefanadi, Ioannis Kallikazaros, 1238-92 Serum soluble Fas and soluble Fas Ligand in Christodoulos Stefanadis, First Cardiology Clinic, University of Hypertension in Pregnancy Athens, Hippokration Hospital, Athens, Greece Hypertension, Prevention and Lipids Hypertension, Vellore J. Karthikeyan, Shahirose Jessani, Balu Balakrishnan, Learning Objective: identify the role of nocturnal hypertension in the Deirdre A. Lane, Sabah Baghdadi, D. Gareth Beevers, Gregory Y H development of target organ damage even in dipper hypertensives Lip, University Department of Medicine, City Hospital, Birmingham, United Kingdom 1237-87 The Detrimental Effect of Chronic Periodontal Disease and Systemic Inflammation on Endothelial Learning Objective: To demonstrate a variability in apoptotic factors Dysfunction in Untreated Hypertensive Patients in hypertension in pregnancy

C. THOMOPOULOS, K. TSIOUFIS, N. SOLDATOS, G. GIAMARELOS, 1238-93 Rho-kinase Activity Is Increased In Hypertensive C. DENDRINOS, M. SELIMA, A. KASIAKOGIAS, E. STEFANADI, D. Patients With Left Ventricular Hypertrophy. TOUSOULIS, C. STEFANADIS, First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, Greece Luigi Gabrielli, Jorge Jalil, Ivan Godoy, Paul McNab, Ivonne Padilla, Samuel Cordova, Paola Rigotti, Ulises Novoa, Italo Mora, Sergio Learning Objective: identify that early stages of periodontal disease Lavandero, Lorena Garcia, Maria P. Ocaranza, Pontificia Universidad may constitute a sub-clinical accelerator of widespread vascular Catolica de Chile, Santiago, Chile, Universidad de Chile, Santiago, Chile damage Learning Objective: To evaluate circulating levels of Rho kinase activity in hypertensive patients with or without left ventricular 1237-88 Pulsatile Versus Steady Components of Blood Pressure and Their Relations With Aortic Stiffness: hypertrophy A Bone to Pick? 1238-94 The Impact of Genetic Polymorphism T45G on Panagiotis Xaplanteris, Charalambos Vlachopoulos, Gregory Adiponectin Gene on the Expression of Adipokines Vyssoulis, Ioanna Dima, Katerina Baou, Konstantinos Aznaouridis, in Arterial Hypertension Dimitrios Terentes-Printzios, Aikaterini Siama, Christodoulos Stefanadis, 1st Cardiology Department, Athens Medical School, Alexis S. Antonopoulos, Dimitris Tousoulis, Charalambos Hippokration Hospital, Athens, Greece Antoniades, Antigoni Miliou, Nikolaos Koumallos, George Hatzis, Michael Dimosthenous, Constantinos Bakogiannis, Costas Tsioufis, Learning Objective: to distinguish between steady and pulsatile Kostas Toutouzas, Christodoulos Stefanadis, 1st Cardiology components of blood pressure as predictors of aortic stiffness. Department Hippokration Hospital, Athens, Greece Learning Objective: Understand how adiponectin affects the risk of hypertension development JACC March 9, 2010 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids A61

1238-95 Higher Chymase Dependent Angiotensin II-Forming 1239-100 Hormonal and Electrolyte Responses to the Activity in the Circulating Mononuclear Leukocyte Aldosterone Synthase Inhibitor LCI699 in Sodium is a Significant Contributing Factor for Atrial Depleted Healthy Subjects Fibrillation Joël Menard, Catherine Watson, Sam Rebello, Yiming M. Zhang, Keisuke Okamura, Yukiko Inoue, Yoshinari Uehara, Kenzo William P. Dole, Université Paris Descartes, Paris, France, Novartis Matsumoto, Seiyo Maruyama, Shunichiro Sumi, Yusuke Fukuda, Institutes of Biomedical Research, Cambridge, MA Shodai Furuyama, Sunao Kodama, Chie Andoh, Hideya Niimura, Learning Objective: Evaluate the pharmacokinetics and Kazumitsu Kubota, Hideaki Tohjoh, Kei Miyoshi, Shinichiro Miura, pharmacodynamics of LCI699, an aldosterone synthase inhibitor Yoshio Yamanouchi, Keijiro Saku, Hidenori Urata, Department of Cardiovascular Diseases,Fukuoka University Chikushi Hospital, Blood Pressure Reduction with the Novel Dual- Chikushino, Japan, Department of Cardiology, Fukuoka University, 1239-101 Fukuoka, Japan Acting Angiotensin Receptor Neprilysin Inhibitor LCZ696: A Randomized, Multicenter, Double-Blind, Learning Objective: learn that higher chymase dependent Placebo-Controlled, Active-Comparator Study angiotensin II-forming activity in the circulating mononuclear leukocyte is a significant contributing factor for atrial fibrillation Michael Böhm, Luis M. Ruilope, Yves Lacourciere, Andrej Dukat, Jim Gong, Martin Lefkowitz, Saarland University, Homburg/Saar, 1238-96 Early Increase in Circulating Autoantibodies Germany, Hospital 12 de Octubre, Madrid, Spain against Human Oxidized Low-density Lipoprotein in Learning Objective: appreciate that angiotensin receptor blockade Hypertensive Patients after Blood Pressure Control and neprilysin inhibition are complementary modes of action as shown by the greater BP lowering of LCZ696 compared with valsartan Maria Cristina Izar, Sergio A. Brandao, Simone C. Fischer, Rui M. Povoa, Carlos M. Monteiro, Andrea M. Monteiro, Magnus Gidlund, Antonio M. Figueiredo Neto, Antonio C. Carvalho, Francisco A. 1239-102 Effect of Renin Angiotensin System (RAS) Blockade Hypertension, Prevention and Lipids Fonseca, Federal University of Sao Paulo, Sao Paulo, Brazil, on Calcium Antagonist Associated Pedal Edema University of Sao Paulo, Sao Paulo, Brazil

Harikrishna J. Makani, Franz H. Messerli, Christopher Di Giorgio, General Cardiology: Learning Objective: Describe antibody behaviour after blood Jorge Romero, Maria Elena De Benedetti Zunino, Jorge Silva Enciso, pressure control St. Luke’s Roosevelt Hospital and Columbia University College of Physicians and Surgeons, New York, NY

1239 HYPERTENSION AND THE RENIN-ANGIOTENSIN- Learning Objective: appreciate that angiotensin receptor blockade and neprilysin inhibition are complementary modes of action ALDOSTERONE SYSTEMS as shown by the greater BP lowering of LCZ696 compared with Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. valsartan Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. 1240 CENTRAL BLOOD PRESSURE DRUGS AND GENES CME/CE Hours: 1 Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 1239-98 Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Pregnancy: an Presentation Hour: 9:30 a.m. - 10:30 a.m. Increasing Problem CME/CE Hours: 1

Vellore J. Karthikeyan, Robin E. Ferner, Sabah Baghdadi, Deirdre 1240-103 Responses to Aliskiren/HCTZ versus Amlodipine on A. Lane, Gregory Y H Lip, D. G. Beevers, University Department of Peripheral and Central Blood Pressure in African Medicine, Birmingham, United Kingdom American Patients with Stage 2 Hypertension Learning Objective: Demonstrate high incidence of adverse pregnancy outcomes in women on ACE-I or ARBs. Keith Ferdinand, James Pool, Richard Weitzman, Das Purkayastha, Raymond Townsend, Emory University, Decatur, GA 1239-99 Blockade of Aldosterone Production as a Learning Objective: understand the disparity of response of Novel Approach to the Management of High antihypertensive agents on central pressure vs peripheral pressure Blood Pressure: Efficacy and Tolerability of the and how that relates to treatment choices in hypertensive patients Aldosterone Synthase Inhibitor LCI699 in Patients with Stage 1-2 Hypertension 1240-104 The Effect of Calibration Error on the Transfer- function-derived Central Aortic Blood Pressure William B. White, David A. Calhoun, Henry Krum, Weinong Guo, Angelo J. Trapani, Martin Lefkowitz, Joel Menard, University of Hao-min Cheng, Yuan-Ta Shih, Kang-Ling Wang, Yi-Jung Sun, Ying- Connecticut School of Medicine, Farmington, CT, University of Hwa Chen, Shing-Jong Lin, Lung-Ching Chen, Lung-Ching Chen, Lung- Alabama at Birmingham, Birmingham, AL Ching Chen, Shih-Hsien Sung, Wen-Shin Lee, Wen-Chung Yu, Wei- Chih Hu, Chen-Huan Chen, Taipei Veterans General Hospital, Taipei, Learning Objective: understand the antihypertensive efficacy and Taiwan,ROC, National Yang-ming University, Taipei, Taiwan,ROC safety of aldosterone synthase inhibition Learning Objective: to understand the errors of central BP estimation could be resulted and predicted from the inaccuracy of cuff BP measurements A62 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids JACC March 9, 2010

1240-105 The p22phox -930A/G Polymorphism of NADPH 1241-111 Systolic Blood Pressure and Treatment Outcomes in Oxidase Adversely Affects Peripheral and Central Chronic Heart Failure Pressures in Healthy Normotensive Individuals Keun-Suh Kim, Venkataramana Reddy, DK Petersen, S. Westrom, Panagiotis Xaplanteris, Charalambos Vlachopoulos, Katerina Baou, Carmen Jun R. Chiong, Loma Linda University, Loma Linda, CA Vassiliadou, Ioanna Dima, Nikolaos Ioakeimidis, Nikolaos Alexopoulos, Learning Objective: Identify the importance of proper titration of Dimitrios Tousoulis, Christodoulos Stefanadis, 1st Cardiology Department, blood pressure medication in chronic heart failure patients and its Athens Medical School, Hippokration Hospital, Athens, Greece role in the outcome of such patients Learning Objective: identify the role of the p22phox -930A/G polymorphism of NADPH oxidase in the regulation of peripheral and 1241-112 Is Mid Ascending Aortic Diameter Smaller in central blood pressure Patients with Hypertension or Heart Failure with Preserved Ejection Fraction? 1240-106 Different Effects of Aliskiren/Hydrochlorotiazide and Atenolol/Hydrochlorotiazide Combinations on Selma F. Mohammed, Barry A. Borlaug, Alessandro Cataliotti, Central Pressure in Elderly Hypertensive Patients Margaret M. Redfield, Mayo Clinic, Rochester, MN Learning Objective: Define the factors affecting mid ascending Roberto Fogari, Amedeo Mugellini, Paola Preti, Maurizio Destro, aortic diameter. Compare mid ascending aortic diameter in normal, Luca Corradi, Giuseppe Derosa, Department of Internal Medicine, hypertensive and subjects with HFpEF. University of Pavia, Pavia, Italy Learning Objective: These results indicate that in elderly 1241-113 Prognostic Role of CA125 in a Population at High hypertensive patients AL/HCTZ combination reduces central aortic Risk for Cardiovascular Disease: Results From the pressure, augmentation pressure and plasma BNP more than AT/ PROBE-HF Study HCTZ combination, despite a similar Irene Betti, Piercarlo Ballo, Alessandro Barchielli, Alfredo Zuppiroli, 1240-107 Estimation of Central Blood Pressure by Carotid Unità Operativa di Cardiologia, Ospedale S. Maria Annunziata, tonometry, Radial tonometry, and Brachial Azienda Sanitaria di Firenze, Firenze, Italy Plethysmography: A Comparative study Learning Objective: Evaluate the prognostic value of CA 125 in a large cohort of subjects with hypertension and diabetes from primary care. Hao-min Cheng, Shih-Hsien Sung, Pai-Feng Hsu, Kang-Ling Wang, Wen-Shin Lee, Wen-Chung Yu, Yao-Ping Lin, Chen-Huan Chen, Taipei Veterans General Hospital, Taipei, Taiwan,ROC 1242 HYPERTENSION AND OBESITY Learning Objective: to understand the methods of estimation of Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. central blood pressure and know the differences among them and General Cardiology: General their relations with left ventricular mass Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Hypertension, Prevention and Lipids Hypertension, 1241 HYPERTENSION AND HEART FAILURE Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. 1242-115 Type 2 Diabetes Mellitus and the Intrarenal Renin System: Influence of Obesity Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. George V. Moukarbel, Naomi D.L. Fisher, Norman K. Hollenberg, CME/CE Hours: 1 Brigham and Women’s Hospital, Harvard Medical School, Boston, MA Learning Objective: understand the influence of obesity and 1241-109 Is Isolated Diastolic Hypotension a New Risk Factor abnormal glycemic control on renal hemodynamics. for Incident Heart Failure in Community-Dwelling Older Adults? 1242-116 Sensitivity of Modern Electrocardiographic Criteria for Left Ventricular Hypertrophy in Severely Obese Jason L. Guichard, Mustafa I. Ahmed, Marjan Mujib, Michel White, Wilbert S. Aronow, Prakash Deedwania, Ali Ahmed, University of Patients Alabama at Birmingham, Birmingham, AL Brigham Smith, Theophilus Owan, Nathan Smith, Genaro Fernandez, Learning Objective: Appreciate isolated diastolic hypotension (IDH) Sheldon E. Litwin, University of Utah, Salt Lake City, UT as a novel risk factor for new-onset heart failure in older adults. Learning Objective: Compare the utility of ECG with echo in diagnosis of left ventricular hypertrophy in severely obese patients. 1241-110 Cardiac Remodeling and Diastolic Dysfunction Precede non MI-Related Heart Failure in High-Risk 1242-117 Obesity as a Determinant of Left Atrial Size in the Hypertensive Patients: The LIFE Echo Substudy. Early Stages of Hypertension. The Crucial Role of Marcello Chinali, Gerard P. Aurigemma, Peter M. Okin, Eva Waist Circumference Gerdts, Kristian Wachtell, Sverre E. Kjeldsen, Stevo Julius, Björn Efstathios Taxiarchou, Konstantinos Tsioufis, Dimitris Roussos, Dahlöf, Giovanni de Simone, Richard B. Devereux, University of Dimitris Tsiachris, Dimitris Syrseloudis, Costas Thomopoulos, Massachusetts Medical School, Worcester, MA Dimitris Tousoulis, Ioannis Kallikazaros, Christodoulos Stefanadis, Learning Objective: Describe the serial changes in cardiac geometry First Cardiology Clinic, University of Athens, Hippokration Hospital, and function preceding an acute heart failure event in treated Athens, Greece hypertensives Learning Objective: identify the predictors of left atrial dilation in hypertensives JACC March 9, 2010 ABSTRACTS: General Cardiology: Hypertension, Prevention and Lipids A63

1242-118 Association Between Large and Small Artery Elasticity and NT-pro B-type Natriuretic Peptide: Results of the Multi-Ethnic Study for Atherosclerosis

Daniel A. Duprez, David Jacobs, Jr, David Bluemke, Joao Lima, Hossein Bahrami, Carmen Peralta, Michael Criqui, Lori Daniels, Alan Maisel, University of Minnesota, Minneapolis, MN Learning Objective: understand the association of large and small artery elasticity and NT-proB-type Natriuretic pepetide in subjects free of overt cardiovascular disease.

1242-119 Central Obesity Seems to Have the Highest Predictive Value among all Others Anthropometric Indices for the Five-Year Incidence of Hypertension in Apparently Healthy Individuals: The Attica Study christina A. chrysohoou, Demosthenes B. Panagiotakos, Christos Pitsavos, John Skoumas, Yannis Lentzas, Anastasia Katinioti, Constantina Masoura, Akis Zeibekis, Lambros Papadimitriou, Manolis Kambaxis, Vasiliki Metaxa, Christodoulos Stefanadis, 1st Cardiology Clinic, Hippokratio, Athens, Greece, Harrokopio University, Athens, Greece

Learning Objective: Evaluation of waist circumference as better Hypertension, Prevention and Lipids predictor of the 5-year incidence of hypertension than other anthropometric indices. General Cardiology: A64 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

ORAL CONTRIBUTIONS

905 CT CORONARY ANGIOGRAPHY: INSIGHTS INTO 9:00 Increased Vascular Stiffness Measured as Pulse PLAQUE IMAGING Wave Velocity Is Associated with the Presence and Severity of Coronary Artery Disease Sunday, March 14, 2010, 8:00 a.m. - 9:30 a.m. Naser Ahmadi, Vahid Nabavi, Braynce L. Oyang, Shahin Moshrefi, Georgia World Congress Center, Room B403 Sagar J. Pathak, Sourya Sourya-nejad, Hussain Isma’eel, Ramin CME/CE Hours: 1.5 Ebrahimi, Matthew Budoff, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 8:00 Usefulness of Plaque Assessment by 64-Slice Multi- Detector Computed Tomography for Predicting Learning Objective: Increased pulse wave velocity measured by computed tomography angiography strongly correlates with the Stenting-Related Periprocedural Myocardial presence and severity of coronary artery disease independent of Infarction conventional risk factors Tomoe Murakami, Yuichi Kawase, Shinsaku Shimamoto, Hiroshi Ueda, Hiroki Sakamoto, Japanese Red Cross Society Wakayama 909 ECHOCARDIOGRAPHY: NOVEL APPLICATIONS OF Medical Center, Wakayama, Japan THREE-DIMENSIONAL ECHOCARDIOGRAPHY IN Learning Objective: Utilize 64-slice MDCT to predict stenting-related VALVE DISEASE periprocedural myocardial infarction Monday, March 15, 2010, 10:30 a.m. - 12:00 p.m. 8:15 Noninvasive Assessment of Morphological Georgia World Congress Center, Room B403 Changes in Lipid-Rich Coronary Plaque after CME/CE Hours: 1.5 Statin Treatment Using Dual-Source Computed Tomography 10:30 Automated Quantitative Modeling of the Aortic Tsunenari Soeda, Shiro Uemura, Satoshi Okayama, Hitoshi Valve and Root in Aortic Regurgitation Using Nakagawa, Ayako Senoo, Taku Nishida, Ji Hee Sung, Yoshinobu Volume 3-D Transesophageal Echocardiography Morikawa, Satoshi Somekawa, Ken-ichi Ishigami, Hiroyuki Kawata, Anna Calleja, Ionasec Razvan, Helene Houle, Shizhen Liu, Jennifer Manabu Horii, Yoshihiko Saito, Nara Medical University, Kashihara, Dickerson, Paaladinesh Thavendiranathan, Chittoor Sai-Sudhakar, Japan Juan Crestanello, Thomas Ryan, Mani Vannan, Ohio State University, Learning Objective: demonstrate Columbus, OH, Siemens Healthcare, Ultrasound, Mountain View, CA Learning Objective: To demonstrate the feasibilty of obtaining 8:30 Automated 3-D Plaque Quantification from conventional and non conventional aortic valve and root parameters Coronary CT Angiography: Comparison with in patients with aortic regurgitation using 3D echocardiography Intravascular Ultrasound Catheter Based, Percutaneous Mitral Valve Clipping Damini Dey, Tiziano Schepis, Mohamed Marwan, Piotr J. Slomka, 10:45 Daniel S. Berman, Stephan Achenbach, Cedars-Sinai Medical - The Added Value of Real Time Transesophageal Center, Los Angeles, CA, University of Erlangen, Erlangen, Germany Echocardiography Learning Objective: Identify that automated threshold-based Robert J. Siegel, Gila Perk, Takahiro Shiota, Itzhak Kronzon, James quantification of plaque components from coronary CT angiography Slater, Saibal Kar, Asma Hussani, Simon Biner, Cedars-Sinai Medical

Imaging and Diagnostic Testing Imaging and Diagnostic allows accurate measurement compared with invasive intravascular Center, Los Angeles, CA, NYU Langone Medical Center, New York, NY ultrasound. Learning Objective: Role of 3D TEE in percutaneous mitral repair Coronary Computed Tomography Angiography with 8:45 11:00 Automated 3-D Characterization and Quantification a 3-D Highly Standardized Method Can Accurately of Proximal Isovelocity Surface Area and Vena Quantify Plaque Geometry and Compositional Contracta of Mitral Regurgitation by Real-Time Parameters Using Intravascular Ultrasound with Volume Color Doppler Imaging: Initial Clinical Radiofrequency Analysis as Reference Standard Experience

Sarah Rinehart, Gustavo Vazquez, Zhen Qian, Idean Marvasty, Shizhen Liu, Saurabh Datta, Adrien Ntinunu, Thomas Van Houten, Anna Kalynych, Dimitri Karmpaliotis, Charles Brown, Szilard Voros, Nathalie De Michelis, Joel Mancina, Mary Ellen Orsinelli, Helene Piedmont Heart Institute, Atlanta, GA Houle, Dawn Lombardo, Paaladinesh Thavendiranathan, David Learning Objective: Identify that with utilization of a highly Orsinelli, Peng Li, Thomas Ryan, Mani Vannan, The Ohio State standardized method, CTA can accurately quantify coronary plaque University, Columbus, OH, Siemens Medical Solutions USA Inc., compared to the gold standard VH-IVUS. Mountain View, CA Learning Objective: Measure 3-D PISA and VC in Mitral Regurgitation JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A65

11:15 Determination of Aortic Valve Annular Dimension 2:30 Microvascular Obstruction Assessed by 3-Tesla Prior to Percutaneous Aortic Valve Replacement Magnetic Resonance Imaging in Acute Myocardial with CoreValve: A Comparison of Multi-Modality Infarction: Correlation with Plasma Troponin I Levels Imaging Techniques Charles Daragon, Jerome Iehl, Nicolas Meneveau, Alexandre Comte, Siobhan M. Lockwood, Ian T. Meredith, Paul R. Antonis, Sujith Francois Schiele, Bruno Kastler, University Hospital Jean Minjoz, K. Seneviratne, Philip M. Mottram, Stuart Moir, MonashHeart, Besancon, France Melbourne, Australia, Monash Cardiovascular Research Centre, Learning Objective: describe the correlation between plasma Melboure, Australia Troponin levels and microvascular obstruction as assessed by MRI Learning Objective: Demonstrate techniques for evaluation of aortic in acute MI vavle annular dimension 2:45 Influence of Reperfusion Hemorrhage on Myocardial 11:30 Does 3D Transesophageal Imaging Add Value to Infarct Size and Left Ventricular Function as Transcatheter Aortic Valve Implantation? Experience Determined by Cardiovascular Magnetic Resonance in 150 Cases Imaging

Amit Bhan, Rafal Dworakowski, Lindsay A. Smith, Philip A. Adam Mather, Aleksandra Radjenovic, John P. Greenwood, Sven MacCarthy, Simon Redwood, Ahmed El-Gamel, Christopher Young, Plein, University of Leeds, Leeds, United Kingdom Vinayat Bapat, Jane Hancock, Olaf Wendler, Martyn R. Thomas, Learning Objective: identify patients with reperfusion hemorrhage Mark J. Monaghan, Kings Health Partners, London, United Kingdom following primary percutaneous coronary intervention which may be Learning Objective: Evaluate the use of 3D transesophageal useful in further risk stratification post acute myocardial infarction. echocardiography in transcatheter aortic valve implantation 3:00 Role of Myocardial Haemorrhage in Predicting Adverse Left Ventricular Remodeling after 911 MAGNETIC RESONANCE IMAGING: Reperfused Acute Myocardial Infarction. Can We CARDIOVASCULAR MAGNETIC RESONANCE IN Outperform Microvascular Obstruction? ACUTE CORONARY SYNDROMES Claudia Raineri, Annalisa Turco, Sergio Leonardi, Mara Bonardi, Monday, March 15, 2010, 2:00 p.m. - 3:30 p.m. Michela Cottini, Guido Tavazzi, Margherita Calcagnino, Gabriele Georgia World Congress Center, Room B403 Crimi, Maurizio Ferrario, Mario Previtali, Fondazione IRCCS

CME/CE Hours: 1.5 Policlinico S.Matteo, Pavia, Italy Imaging and Diagnostic Testing Learning Objective: Describe the relative ability of myocardial 2:00 Clinical Assessment of No-Reflow in Humans: hemorrhage and microvascular obstruction in identifying patients at Comparison between Cardiac Magnetic Resonance risk for adverse left ventricular remodeling after an acute myocardial and Angiography infarction.

Martina Perazzolo Marra, Luisa Cacciavillani, Francesco Corbetti, Giuseppe Tarantini, Cristina Basso, Armando Marzari, Manuel De 917 POSITRON EMISSION TOMOGRAPHY: ISCHEMIA Lazzari, Veronica Spadotto, Filippo Zilio, Sabino Iliceto, Division AND MICROVASCULAR FUNCTION of Cardiology, Departments of Cardiac, Thoracic, and Vascular Sciences, Padua, Italy Tuesday, March 16, 2010, 8:00 a.m. - 9:30 a.m. Learning Objective: identify microvascular injury from a Georgia World Congress Center, Room B403 comprehensive evaluation between magnetic resonance and CME/CE Hours: 1.5 angiography 8:00 Comparison of F-18 Labeled BMS747158 PET 2:15 Impact of Early versus Late Microvascular and Tc-99m Labeled SPECT Myocardial Perfusion Obstruction Assessed by Magnetic Resonance Imaging for Detection and Evaluation of Coronary Imaging on Long-Term Outcome after ST-Elevation Artery Disease Myocardial Infarction Jamshid Maddahi, Johannes Czernin, Alexander Ehlgen, Joel Suzanne De Waha, Steffen Desch, Ingo Eitel, Matthias Gutberlet, Lazewatsky, Qi Zhu, Michael Phelps, David Geffen School of Gerhard Schuler, Holger Thiele, University of Leipzig – Heart Center, Medicine at UCLA, Los Angeles, CA, Lantheus Medical Imaging, Department of Internal Medicine – Cardiology, Leipzig, Germany Billerica, MA Learning Objective: interpret the presence and extent of late MO Learning Objective: describe potential advantages of PET myocardial as strong independent predictors for the occurrence of death, perfusion imaging with the new tracer BMS747158 vs. SPECT reinfarction and congestive heart failure after STEMI in contrast to early MO. A66 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

8:15 A Pilot Study of Left Ventricular Ejection Fraction 923 TISSUE IMAGING: CLINICAL IMPACT OF NOVEL Reserve during Regadenoson Rubidium-82 IMAGING APPROACHES TO QUANTIFY CARDIAC Myocardial Perfusion Imaging and the Magnitude of FUNCTION Ischemia and CAD Tuesday, March 16, 2010, 2:00 p.m. - 3:30 p.m. Edward Hsiao, Bilal Ali, Ron Blankstein, Raymond Kwong, Marcelo Di Carli, Sharmila Dorbala, Brigham and Women’s Hospital, Boston, MA Georgia World Congress Center, Room B403 CME/CE Hours: 1.5 Learning Objective: to understand the relation between left ventricular ejection reserve and the extent of ischemic burden and Multiplane Speckle Tracking Imaging to Quantify angiographic CAD 2:00 Dyssynchrony and Predict Long-Term Outcome after Cardiac Resynchronization Therapy 8:30 Coronary Circulatory Dysfunction Is Associated with Diastolic Dysfunction in Individuals at Hidekazu Tanaka, Olusegun Oyenuga, Phillip Habib, Evan C. Cardiovascular Risk Adelstein, John Gorcsan, III, University of Pittsburgh, Pittsburgh, PA

Alessandra Quercioli, Maria Gabriella Vincenti, René Nkoulou, Learning Objective: demonstrate that a multiplane speckle-tracking Stephan Dewarrat, Yann Seimbille, Osman Ratib, François Mach, imaging approach successfully quantified dyssynchrony and Thomas H. Schindler, University Hospital of Geneva, Cardiovascular predicted long-term outcome to CRT. Center, Geneva, Switzerland Analysis of Left Ventricular Lead Position in Cardiac Learning Objective: Evaluate the effect of coronary circulatory 2:15 Resynchronization Therapy Using Different Imaging dysfunction on diastolic function in cardiovascular risk individuals without CAD by means of N-13 ammonia PET Modalities Michael Becker, Ertunc Altiok, Renate Hoffmann, Patrick Schauerte, 8:45 PET-Determined Longitudinal, Myocardial Flow Christian Koch, Rainer Hoffmann, Department of Cardiology, Gradient during Hyperemia in Cardiovascular Aachen, Germany Risk Individuals with or without Coronary Artery Learning Objective: identify optimal LV lead position Calcifications Thomas H. Schindler, Ines Valenta, Gabriella Vincenti, Alessandra 2:30 Characterization of Regional Heterogeneity in Left Quercioli, Rene Nkoulou, Stefan Dewarrat, Yann Seimbille, Osman Atrial Reservoir and Conduit Function by Speckle Ratib, Francois Mach, Thomas H. Schindler, Cardiovascular Center, Tracking Echocardiography University Hospital of Geneva, Geneva, Switzerland, Nuclear Medecine, University Hospitals of Geneva, Geneva, Switzerland Samir K. Saha, Paula L. Anderson, Giuseppe Caracciolo, Susan Wilansky, Anatoli Kiotsekoglou, James C. Moggridge, Satish C. Learning Objective: interpret myocardial flow heterogeneity as Govind, A. J. Camm, Lars-Ake Brodin, Partho P. Sengupta, Sundsvall functional precursor of CAD Regional Hospital, Sundsvall, Sweden, Mayo Clinic Arizona, Scottsdale, AZ Flow-Mediated Vasodilation Can Predict Silent 9:00 Learning Objective: To evaluate left atrial strain in atrial fibrillation Ischemia: Twins Study Ambar Kulshreshtha, Emir Veledar, Yan Zheng, Durreshahwar Khan, 2:45 Two-Dimensional Speckle Strain Imaging Identifies Arshed A. Quyyumi, Jun Dai, Irina Uphoff, Douglas J. Bremner, Jack Depressed Left Atrial Function in Hypertensive Goldberg, Viola Vaccarino, Emory University School of Medicine, Patients with Diastolic Dysfunction Imaging and Diagnostic Testing Imaging and Diagnostic Atlanta, GA Umar A. Khan, Marcello Chinali, Gerard P. Aurigemma, Jeffrey C. Hill, Learning Objective: Predict Silent Ischemia through Flow mediated Giovanni de Simone, Dennis A. Tighe, University of Massachusetts Vasodilation Medical School, Worcester, MA Learning Objective: Identify early predictors of Diastolic Dysfunction

3:00 Diastolic Strain Rate Imaging Using a Prototype Radiofrequency-Based Speckle Tracking Echocardiography System for Assessment of Diastolic Function

Theodore J. Kolias, Matthew O’Donnell, Nicole M. Kline, Lingling Zhang, James D. Hamilton, University of Michigan, Ann Arbor, MI Learning Objective: Evaluate a new method for assessing diastolic function using a prototype speckle tracking echocardiography system JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A67

POSTER CONTRIBUTIONS

1033 CT CORONARY ANGIOGRAPHY: RADIATION 1033-193 Effect of a Standardized Body Mass Index- and EXPOSURE AND SPECIAL USES Heart Rate-Based Protocol on Radiation Dose and Diagnostic Accuracy of Coronary Computed Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Tomographic Angiography: A Prospective Georgia World Congress Center, Hall B5 Multicenter Study Presentation Hour: 9:30 a.m. - 10:30 a.m. Troy LaBounty, Jonathon Leipsic, G.B. John Mancini, Brett Heilbron, CME/CE Hours: 1 Smita Patel, Ella A. Kazerooni, Fay Y. Lin, Adam Saltzman, Giora Weisz, Jonathan W. Weinsaft, Jin-Ho Choi, Nina Koduru, James K. 1033-188 Predictors of Various Artifacts in Coronary Arterial Min, Cornell Medical College, New York, NY, University of Britich Images in Subjects with Chronic Atrial Fibrillation Columbia, Vancouver, BC, Canada by 320 Slice Computed Tomography Considering Learning Objective: Identify the impact of a standardized protocol Reconstruction Method on the radiation dose and diagnostic accuracy of coronary CT Masae Uehara, Nobusada Funabashi, Issei Komuro, Department angiography. of Cardiovascular Science and Medicine, Chiba University, Chiba, Japan 1033-194 Emergency Department Discharge After a Single Troponin and Normal 320-Slice Coronary Computed Learning Objective: identify that in subjects with chronic atrial Tomographic Angiogram: A Unique Model for Chest fibrillation, various artifacts still occur in 320 slice CT, and sufficient heart rate control by administration of beta block may be Pain Evaluation recommended. Arthur Nasis, Ian T. Meredith, Nitesh Nerlekar, James D. Cameron, Paul R. Antonis, Philip M. Mottram, Sujith K. Seneviratne, Monash 1033-189 Reduction of Radiation Dose of 320-Row Coronary Cardiovascular Research Centre, MonashHEART, Melbourne, Computed Tomography Angiography Through Prior Australia, Monash University Department of Medicine (MMC), Coronary Calcium Scanning Melbourne, Australia

Marc Dewey, Elke Zimmermann, Ulrike Wollenberg, Matthias Rief, Learning Objective: describe the utility of a computed tomographhic Johannes Greupner, Bernd Hamm, Charité, Berlin, Germany guided approach to the investigation of acute chest pain. Learning Objective: At the conclusion of this presentation, Coronary Calcium Score And Clinical Risk Imaging and Diagnostic Testing participants will be able to determine the dose-saving 1033-195 Factors Fail To Predict The Burden Of Coronary characteristics of coronary artery calcium scanning prior to 320-row coronary CT angiography. Atherosclerosis In Asymptomatic Diabetic Patients: The Factor 64 Study

1033-191 Low-Dose CT Coronary Angiography with Khurram S. Zakaria, Christopher T. Sibley, Andrea L. Vavere, David A. Prospective ECG-Triggering Accurately Predicts Bluemke, Rukhsar Ahmed, Hiroyuki Niinuma, Joao AC Lima, Donald Events in Patients with Known or Suspected L. Lappe, Jeffrey L. Anderson, Joseph B. Muhlestein, Johns Hopkins Coronary Artery Disease University, Baltimore, MD, Intermountain Medical Center, Murray, UT

Ronny R. Buechel, Aju P. Pazhenkottil, Bernhard A. Herzog, René N. Learning Objective: Corelation of calcium scores with total Nkoulou, Irene A. Burger, Ines Valenta, Christophe A. Wyss, Lars atherosclerotic plaque burden Husmann, Philipp A. Kaufmann, University Hospital Zurich, Zurich, Switzerland 1034 RADIATION EXPOSURE WITH CT CORONARY Learning Objective: Recognize low-dose CT coronary angiography ANGIOGRAPHY as a tool that accurately predicts outcome while using very low radiation dose (less than 2mSv) Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 1033-192 80 kV Coronary CT Angiography for Low-body Presentation Hour: 9:30 a.m. - 10:30 a.m. Weight Patients CME/CE Hours: 1 Sei Komatsu, Teruaki Kamata, Atsuko Imai, Jyunichi Yoshida, Tomoki Ohara, Kazuaki Miyaji, Yoshinobu Shimizu, Kazuisa Kodama, 1034-197 Reduction in Estimated Lifetime Cancer Incidence Department of Cardiology, Amagasaki Central Hospital, Hyogo, and Mortality Using Cardiac Prospective ECG Japan, Department of Radiological Technology, Amagasaki Central Triggered CT Compared to Retrospective Gated CT Hospital, Hyogo, Japan Kelley R.H. Branch, Adam M. Alessio, Kalpana M. Kanal, William Learning Objective: learn minimum invasive CTCA P. Shuman, James H. Caldwell, James P. Earls, University of Washington, Seattle, WA, Fairfax Radiological Consultants PC, Fairfax, VA Learning Objective: To describe the lifetime attributable risks of cancer for cardiac CT overall and for prospective-triggered CT compared to retrspective-gated CT A68 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1034-198 0.3mSv Coronaries - Initial Experience With an Ultra 1035 CONTRAST ECHOCARDIOGRAPHY Low Dose Scan Protocol Using a 128-Slice Dual Source CT Scanner Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Kheng Thye Ho, Christoph Panknin, Kia Chong Chua, Tan Tock Seng Presentation Hour: 9:30 a.m. - 10:30 a.m. Hospital, Singapore, Singapore CME/CE Hours: 1 Learning Objective: Identify ultra low dose radiation techniques for CT angiography 1035-205 Angiogenic Effects of the HIF-1α With Triple-point Mutations Evaluated by Ultrasound Molecular 1034-199 First Experience With Single Heart Beat Coronary Ct Imaging Angiography In 2Nd Generation Dual-source Ct Jian_Ping Bin, Jia-jia Xie, Jue-fei Wu, Li Yang, Ming-yan Li, Guang- Bernhard Bischoff, Tanja Meyer, Bettina Gramer, Franziska Hein, quan Hu, Jing-jing Cai, Yun-bin Xiao, Ping-sheng Wu, Nanfang Martin Hadamitzky, Albert Schömig, MD, Stefan Martinoff, Jörg Hospital,Southern Medical University, , People’s Republic Hausleiter, Deutsches Herzzentrum Muenchen, Munich, Germany of China Learning Objective: understand radiation dose reduction techniques Learning Objective: Demonstrate an optimal angiogenic effect of the HIF-1α with triple-point mutations in vivo. Identify the usefulness 1034-200 Image Quality and Radiation Exposure of Low-dose of ultrasound molecular imaging in assessment of therapeutic Protocols for Coronary CT Angiography: Comparison angiogenesis. of Prospective Axial Scanning and High-pitch Spiral Acquisition 1035-206 In Vivo Ultrasound Molecular Imaging of Arterial Thrombus with Cyclic RGD-modified Microbubbles Stephan Achenbach, Martin Seltmann, Tobias Pflederer, Mohamed Marwan, Dieter Ropers, Michael Lell, Katharina Anders, Axel Jian_Ping Bin, Guang-quan Hu, Jue-fei Wu, Li Yang, Jian-guo Bin, Kuettner, Michael Uder, Werner G. Daniel, Department of Cardiology, Ying Liu, Dong-dong Chen, Yun-bin Xiao, Li-jing Ji, Nanfang Hospital, University of Erlangen, Erlangen, Germany, Department of Radiology, Southern Medical University, Guangzhou, People’s Republic of China University of Erlangen, Erlangen, Germany Learning Objective: Demonstrate the efficacy of cyclic RGD-modified Learning Objective: Identify advantages and disadvantages of microbubbles on ultrasound molecular imaging of arterial thrombus prospectively ECG-triggered axial versus high pitch spiral acquisition in vivo, and address its value in detection of thrombus. for coronary CT angiography 1035-208 Efficacy Of Novel Magnetic Microbubbles Targeted 1034-201 A Prospective Multicenter Study Evaluating the To Vcam-1 In The Assessment Of Inflammation In Diagnostic Accuracy of High-Definition Coronary Early Stage Of Atherosclerosis Computed Tomographic Angiography: An Intent-to- Diagnose Analysis Juefei Wu, Jianping Bin, Li Yang, Jingjing Cai, Jiajia Xie, Dongdong Chen, Yuegang Wang, Guangquan Hu, Yili Liu, Nanfang Hospital, Troy LaBounty, Jonathon Leipsic, G.B. John Mancini, Brett Heilbron, South Medical University, Guangzhou, People’s Republic of China Smita Patel, Ella Kazerooni, Fay Y. Lin, Giora Saltzman, Adam Learning Objective: Demonstrate the excellent efficacy of novel Saltzman, Jonathan W. Weinsaft, Jin-Ho Choi, Nina Koduru, James magnetic microbubbles targeted to VCAM-1 in high-shear flow. K. Min, Cornell Medical College, New York, NY, University of Britich Address the value of the microbubbles in detecting inflammation in Columbia, Vancouver, BC, Canada early stage atherosclerosis.

Imaging and Diagnostic Testing Imaging and Diagnostic Learning Objective: Describe the diagnostic accuracy of high- definition coronary CT angiography to detect significant coronary 1035-209 Jeopardized Myocardium Assessed by Myocardial artery disease. Contrast Echocardiography predicts Mortality in Heart Failure Patients 1034-203 Coronary CTA Below One Millisievert: Evaluation of Image Quality and Patient Dose, and Selection of Brijesh Anantharam, Rajesh Chelliah, Sajad Hayat, Michael Appropriate Scan Protocols in the First 200 Cardiac Hickman, Roxy Senior, Northwick Park Hospital, Harrow, United Patients on a 128-Slice Dual Source CT Scanner Kingdom Learning Objective: To demonstrate prognostic value of MCE in Kheng Thye Ho, Christoph Panknin, Kia Chong Chua, Tan Tock Seng heart failure patients Hospital, Singapore, Singapore

Learning Objective: describe low-dose imaging of coronary arteries 1035-210 Reduction in Ultimate Infarct Size Despite Persistent Epicardial Occlusion Using Three 1034-204 320-Multidetector Computed Tomography Dimensional Transthoracic Ultrasound and Angiography is Associated with Significant Intravenous Non-targeted Microbubbles Reduction in Radiation Exposure, Compared to 64-Multislice Technology Thomas Richard Porter, Jeroen Slikkerveer, Shunji Gao, Evan Unger, Terry Matsunaga, John Lof, Feng Xie, University of Nebraska Medical Ayesha F. Shaukat, II, Idean B. Marvasty, Lori Meyers, Allison Drew, Center, Omaha, NE Sarah Rinehart, Gustavo Vazquez, Zhen Qian, Parag Joshi, Eric Learning Objective: To Determine how Ultrasound and Microbubbles Krivitsky, Szilard Voros, Piedmont Heart Institute, Atlanta, GA restore Microvascular Flow Learning Objective: determine the significance of radiation dose difference JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A69

1035-211 Clinical Usefulness of Myocardial Contrast 1036-217 Prognostic Implications of Non-obstructive Coronary Echocardiography for detecting Stress induced Plaques in Patients with Non-ST-segment Elevation Cardiomyopathy in the Emergency Department Myocardial Infarction - A Multidetector Computed Tomography Study Geu-Ru Hong, Jong-Ho Nam, Kyu-Hwan Park, Chang-Woo Sohn, Jung- Hyeon Choi, Sang-Hee Lee, Jong-Sun Park, Dong-Gu Shin, Young-Jo Klaus F. Kofoed, Thomas S. Kristensen, Tobias Kühl, Walther B. Kim, Bong-Sup Shim, Yeungnam University, Daegu, South Korea, Nielsen, Michael B. Nielsen, Henning Kelbæk, Department of Dankook University, Cheonan, South Korea Cardiology, Rigshospitalet, Copenhagen, Denmark, Department of Radiology, Rigshospitalet, Copenhagen, Denmark Learning Objective: distinguish stress induced cardiomyopathy from acute anterior wall infarction by real time myocardial contrast Learning Objective: understand the potential prognostic implications echocardiography of MDCT coronary plaque imaging

1035-212 Six Year Predictive Value of Real Time 1036-218 Prognostic Value of Coronary Computed Perfusion Imaging During Dobutamine Stress Tomographic Angiography in Asymptomatic Patients Echocardiography Martin Hadamitzky, Tanja Meyer, Franziska Hein, Bernhard Bischoff, Kamran Akram, Saritha Dodla, Lynette Smith, Joan Olson, Feng Xie, Stefan Martinoff, Albert Schoemig, Joerg Hausleiter, Deutsches Thomas Porter, University of Nebraska Medical Center, Omaha, NE Herzzentrum, Munich, Germany Learning Objective: Prognostic value of real time perfusion Learning Objective: Describe the predictive value of coronary computed tomography angiography in asymptomatic patients.

PROGNOSTIC VALUE OF CCTA 1036 1036-220 Prognostic Value Of Cta In Smokers And Non- Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. smokers Georgia World Congress Center, Hall B5 Jaap M. Van Werkhoven, Joanne D. Schuijf, Aju Pazhenkottil, Presentation Hour: 9:30 a.m. - 10:30 a.m. Bernard A. Herzog, J Wouter Jukema, Eric Boersma, Ernst E. Van CME/CE Hours: 1 der Wall, Philipp Kaufman, Jeroen J. Bax, Leiden University Medical Center, Leiden, The Netherlands, University Hospital Zurich, Zurich, Switzerland 1036-214 Prognostic Value of Normal Cardiac CT Angiography: a Meta-Analysis Learning Objective: interpret the prognostic value of significant CAD

in smokers Imaging and Diagnostic Testing Edward A. Hulten, Salvatore Carbonaro, Sara Petrillo, Josh Mitchell, Todd C. Villines, Walter Reed Army Medical Center, Washington, DC, Impact of Cardiac Multidetector Computed Mid-Atlantic Permanente Medical Group, Rockville, MD 1036-221 Tomographic Angiography on Perioperative Learning Objective: Recognize the low risk prognosis of normal Outcomes and Cost in Reoperative Cardiac Surgery cardiac CT angiography Gabriel Maluenda, Matthew A. Goldstein, Shrinivas Hebsur, Sion 1036-215 Incremental Prognostic Value of Left Ventricular K. Roy, Gaby Weissman, Guy Weigold, Peter C. Hill, Paul J. Corso, Function Analysis over Coronary Angiography with Steven W. Boyce, Augusto D. Pichard, Ron Waksman, Allen J. Taylor, Multi-Detector Computed Tomography Washington Hospital Center, Washington, DC Learning Objective: To evaluate the potential benefit of cardiac CT Fleur Rianne de Graaf, Jacob van Werkhoven, Joanne Schuijf, Joëlla guidance for redo of cardiac surgery van Velzen, Lucia Kroft, Albert de Roos, Martin Schalij, J. Wouter Jukema, Ernst van der Wall, Jeroen Bax, Leiden University Medical Center, Leiden, The Netherlands 1037 CT CORONARY CALCIUM AND NONCORONARY CT Learning Objective: describe that LV function analysis provides APPLICATIONS incremental prognostic information beyond the assessment of coronary artery stenosis using CTA. Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 1036-216 Prognostic Values Of Multidetector Computed Presentation Hour: 9:30 a.m. - 10:30 a.m. Tomography In Patients With Known Or Suspected CME/CE Hours: 1 Coronary Artery Disease 1037-222 Elucidating the Association of Framingham So Yeon Kim, Kee-Sik Kim, Myeung Joon Seung, Jung Hyeun Kim, and Reynolds Risk Scores with Incidence and Jin Wook Jung, Seung Hee Moon, Young Soo Lee, Jin Bae Lee, Jae Progression of Coronary Artery Calcification in the Kean Ryu, Ji Young Choi, Sung-Gug Chang, Division of Cardiology, Daegu Catholic University, Daegu, South Korea Multi-Ethnic Study of Atherosclerosis Learning Objective: evaluate Andrew P. DeFilippis, Michael J. Blaha, Matthew J. Budoff, Donald M. Lloyd-Jones, Robyn L. McClelland, Chiadi Ndumele, Susan G. Lakoski, Mary Cushman, Nathan D. Wong, Roger S. Blumenthal, Khurram Nasir, Johns Hopkins University, Baltimore, MD Learning Objective: Describe the ability to predict incident and progression of coronary artery calcification, a surrogate for CHD, with the Framingham and Reynolds CHD risk prediction models. A70 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1037-223 Utility of Cardiac Computed Tomography 1038 CT CORONARY CALCIUM AND NONCORONARY CT Angiography to Exclude Clinically Significant APPLICATIONS Obstructive Disease in Patients After Myocardial Perfusion Imaging Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Nimish Patel, Raveen S. Pal, Ferdinand Flores, Matthew J. Budoff, Department of Cardiology, Los Angeles County- Harbor-UCLA Presentation Hour: 9:30 a.m. - 10:30 a.m. Medical Center, Torrance, CA, Los Angeles Biomedical Research CME/CE Hours: 1 Institute, Torrance, CA Normal Values of Left Ventricular Filling Indices by Learning Objective: Demonstrate that cardiac computed tomography 1038-228 Multi-detector Computed Tomography angiography after equivocal, mild or moderate abnormal MPI results in significant cost savings. Yalcin Hacioglu, Mohit Gupta, Yasmin Hamirani, Song S. Mao, Tae Young Choi, Matthew J. Budoff, Los Angeles Biomedical Research 1037-224 Measuring Coronary Artery Calcification in Institute at Harbor-UCLA, Medical Center, Torrance, CA Combination with High-Sensitive C-Reactive Protein Learning Objective: The current study presents a referance for Predicts Hard Coronary Events Beyond Framingham normal values of left ventricular filling indices by MDCT. Risk Score Categories - Data from the Heinz Nixdorf Recall Study 1038-229 Epicardial Adipose Tissue and Coronary Artery Stefan Möhlenkamp, Nils Lehmann, Susanne Moebus, Axel Plaque Characteristics Schmermund, Nico Dragano, Marcus Bauer, Hagen Kälsch, Hagen Nikolaos Alexopoulos, Dalton S. McLean, Matthew Janik, Chesnal Kälsch, Barbara Hoffmann, Andreas Stang, Martina Broecker- Arepalli, Arthur E. Stillman, Paolo Raggi, Emory University, Atlanta, GA Preuss, Klaus Mann, Johannes Siegrist, Karl-Heinz Jöckel, Raimund Erbel, University Clinic Duisburg-Essen, Essen, Germany Learning Objective: understand the association of epicardial adipose tissue volume with the type of coronary atherosclerotic Learning Objective: understand the predictive value of measuring plaque both subclinical coronary atherosclerosis and systemic inflammation 1038-230 Epicardial Adipose Tissue Volume and Coronary Artery Calcium to Predict Myocardial Ischemia 1037-225 Microalbuminuria in Non-Diabetic Patients on Positron Emission Tomography-Computed with Metabolic Syndrome is a Strong Predictor Tomography Studies of Subclinical Atherosclerosis: A Multi-Ethnic Perspective Matthew James Janik, Gregory Hartlage, Nikolaos Alexopoulos, Zaur Mirzoyev, Dalton S. McLean, Chesnal Arepalli, Arthur E. Stillman, Pawan K. Hari, Vikas Veeranna, Palaniappan Manickam, Rajeev Paolo Raggi, Emory University, Atlanta, GA Sudhakar, Jyotiranjan Pradhan, Ashutosh Niraj, Sony Jacob, Luis Afonso, Wayne State University, Detroit, MI Learning Objective: identify epicardial adipose tissue (EAT) volume on CT as an independent predictor of myocardial ischemia on PET. Learning Objective: Identify that microalbuminuria in non-diabetic patients with metabolic syndrome is an incremental predictor of Impact of Total Coronary Calcium Score on coronary artery calcification in a majority of ethnic subgroups 1038-231 Procedural and Long- Term Outcomes in Patients Who Underwent Percutaneous Coronary 1037-226 Utility of a Multiple Biomarker Index in Intervention with Drug Eluting Stents: Three Years Imaging and Diagnostic Testing Imaging and Diagnostic Asymptomatic Adults Depends on Atherosclerotic Burden Follow-up

Nathan D. Wong, Heidi Gransar, Jamal S. Rana, Johanna Kim, Hae Chang Jeong, Youngkeun Ahn, Doo Sun Sim, Hyun Ju Yoon, Romalisa Miranda-Peats, Leslee Shaw, Alan Rozanski, Sean Hayes, Nam Sik Yoon, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Louise Thomson, John Friedman, Daniel S. Berman, University Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Jung Chaee of California, Irvine, Irvine, CA, Cedars-Sinai Medical Center, Los Kang, Chonnam National University Hospital, Gwangju, South Korea Angeles, CA Learning Objective: High coronary calcium score was associated Learning Objective: Understand the possible role of atherosclerosis with poor prognosis assessment in the utility of cardiac biomarkers 1038-232 Correlation of Coronary Artery Calcium Progression with Progression of Coronary Artery Stenosis on Cardiac Computed Tomography

Irfan Zeb, Tigran Khachatryan, Yasmin S. Hamirani, Khurram Nasir, Kelcey N. Nishihara, Sameer Raina, Song S. Mao, Naser Ahmadi, Matthew J. Budoff, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA Learning Objective: Correlation of coronary artery calcium score progression with coronary artery stenosis progression JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A71

1039 CT CORONARY CALCIUM AND NONCORONARY CT 1039-238 The Comparable Utility of Computed Tomography APPLICATIONS and Echocardiography in the Detection of Early Stage Calcific Aortic Valve Disease: An AGES- Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Reykjavik Investigation. Georgia World Congress Center, Hall B5 David S. Owens, Jonathan F. Plehn, Sigurdur Sigurdsson, Jeffrey Presentation Hour: 9:30 a.m. - 10:30 a.m. L. Probstfield, Lenore J. Launer, Gudny Eiriksdottir, Vilmundur CME/CE Hours: 1 Gudnason, Tamara B. Harris, Kevin D. O’Brien, University of Washington, Seattle, WA, Icelandic Heart Association, Reykjavik, 1039-234 Incidental Detection of Malignancy and Other Iceland Non-Cardiovascular Abnormalities on Multislice Learning Objective: Compare the relative merits of echocardiography Computed Tomography in Patients With Severe and CT in the detection of early stage calcific aortic valve disease. Aortic Stenosis Evaluated for Transcatheter Aortic Valve Implantation 1040 CT CORONARY CALCIUM AND NONCORONARY CT Itsik Ben-Dor, Ron Waksman, Nicholas N. Hanna, Arnold Raizon, APPLICATIONS Lowell F. Satler, Rebecca Torguson, Gaby Weissman, Petros Okubagzi, Zhenyi Xue, Yanlin Li, Manuel A. Gonzalez, Michael A. Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Gaglia, Gabriel Maluenda, Kohei Wakabayashi, Cedric Delhaye, Georgia World Congress Center, Hall B5 Asmir I. Syed, Sara D. Collins, William O. Suddath, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard, Washington Hospital Center, Presentation Hour: 9:30 a.m. - 10:30 a.m. Washington DC, DC CME/CE Hours: 1

Learning Objective: To investigated the prevalence and the nature of Pericardial, Thoracic and Subcutaneous Fat significant and insignificant non-cardiovascular findings incidentally 1040-239 Measured by Non-enhanced Computed Tomography found by CT in patients evaluated for trans catheter aortic valve implatation is Associated with Coronary Artery Calcium Naser Ahmadi, Mustapha Lakis, Vahid Nabavi, Fereshteh 1039-235 Age and Gender-specific Pulmonary Artery Hajsadeghi, Ramin Ebrahimi, Matthew Budoff, Los Angeles Measurements by Multi-detector Computed Biomedical Research Institute at Harbor UCLA Medical Center, Tomography: Framingham Heart Study Torrance, CA

Quynh A. Truong, Joseph M. Massaro, Ian S. Rogers, Amir Learning Objective: Increased pericardial, thoracic and Imaging and Diagnostic Testing A. Mahabadi, Caroline S. Fox, Christopher J. O’ Donnell, Udo subcutaneous fat depot is associated with coronary atherosclerosis Hoffmann, Massachusetts General Hospital, Boston, MA, NIH/ measured by coronary artery calcium independent conventional NHLBI, Framingham, MA cardiovascular risk factors

Learning Objective: Determine the normal reference value for mPA The Potential of EBCT for Coronary Artery Calcium and ratio PA by CT. 1040-240 Screening to Evaluate Fatty Liver: Dallas Heart Study 1039-236 Association of Coronary Artery diameter on Non Contrast Cardiac Computed Tomography with Susan Matulevicius, Laura C. Huff, Colby R. Ayers, Roderick McColl, Coronary Artery Calcium Scores and traditional risk Lydia Sczcepaniak, Amit Khera, Ronald M. Peshock, University of factors. Texas Southwestern Medical Center, Dallas, TX

Yasmin S. Hamirani, Emil Avanes, Jigar Kadakia, Khurram Nasir, Learning Objective: evaluate the role of coronary artery calcium Amish Patel, Matthew J. Budoff, Los Angeles Biomedical Research screening electron beam computed tomography in detecting heaptic Institute at Harbor-UCLA, Torrance, CA steatosis. Learning Objective: define the clinical utility and predictive value of 1040-241 The Incremental Prognostic Value of Abdominal measurement of coronary artery diameter in addition to detection of Aortic Calcifications in Patients with Coronary CAC on non contrast CT scans. Artery Disease 1039-237 Geometric Deformity of the Mitral Valve Apparatus Steve Simpson, Bryan Zweig, Darshan Patel, Mouaz H. Al-Mallah, in Ischemic Mitral Regurgitation: Three-Dimensional Henry Ford Heart and Vascular Institute, Detroit, MI Analysis with Multislice Computed Tomography Learning Objective: identify patients at higher risk of mortality Yoshimori An, Shuichiro Kaji, Kitae Kim, Atsushi Yamamuro, Makoto based on abdmonial aortic calcium. Kinoshita, Natsuhiko Ehara, Atsushi Kobori, Takeshi Kitai, Tomoko Tani, Toru Kita, Yutaka Furukawa, Kobe City Medical Center General 1040-242 Heart Disease in Firefighters Linked to Thrombosis Hospital, Kobe, CA, Japan Risk Learning Objective: provide more insights into underlying H. Robert Superko, Laksmana Pendyala, Steve Frohwein, Kathryn mechanisms of ischemic mitral regurgitation Momary, Brenda Garrett, Cathy Skrifvars, Radika Gadesam, Steve Rolader, Celera, Ala, CA, Saint Joseph’s Hospital, Atlanta, GA Learning Objective: thrombogenic coronary heart disease risk in firefighters. A72 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1040-243 Coronary Artery Calcium Predicts Mortality in Low- 1041-249 Impact of Total Coronary Calcium Score on Risk Asymptomatic Men Procedural and Long-Term Outcomes in Patients Who Underwent Percutaneous Coronary Jamal S. Rana, Heidi Gransar, Nathan D. Wong, Prediman K. Intervention with Drug Eluting Stents: 3 Years Shah, Alan Rozanski, John D. Friedman, Sean W. Hayes, Louise E. Thomson, Leslee J. Shaw, Daniel S. Berman, Cedars-Sinai Medical Follow-up Center, Los Angeles, CA Youngkeun Ahn, Hae Chang Jeong, Jum Suk Ko, Min Goo Lee, Keun Learning Objective: Identify low risk asymptomatic men with Ho Park, Hyun Ju Yoon, Nam Sik Yoon, Hyung Wook Park, Kye Hun coronary calcium Kim, Young Joon Hong, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang, Department of Cardiology, Chonnam National University Hospital, Gwangju, South Korea, Heart Research 1041 CT CORONARY CALCIUM AND NONCORONARY CT Center of Chonnam National University Hospital, Gwangju, South APPLICATIONS Korea Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Learning Objective: to evaluate the correlation between the total coronary calcium score and long- term clinical outcomes in patients Georgia World Congress Center, Hall B5 who underwent PCI with drug eluting stents Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1042 CT CORONARY CALCIUM AND NONCORONARY CT 1041-245 Diabetes Mellitus, Coronary Artery Calcification and APPLICATIONS All-Cause Mortality among Asymptomatic Men and Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Women Georgia World Congress Center, Hall B5 Jamal S. Rana, Heidi Gransar, Leslee J. Shaw, Nathan D. Wong, Presentation Hour: 9:30 a.m. - 10:30 a.m. Paolo Raggi, James Min, Tracy Q. Callister, Mathew Budoff, Daniel S. CME/CE Hours: 1 Berman, Cedars-Sinai Medical Center, Los Angeles, CA Learning Objective: Identify that diabetics with CAC score of zero 1042-251 Assessment of plaque burden using Coronary CT are statistically not at an increased risk of all cause death. calcium scores in Police Officers and Firefighters in New York State 1041-246 Biomarkers versus Coronary Artery Calcium for Prediction of Incident Cardiovascular Events M. Zubair Jafar, Navdeep Bhatti, Danyaal Moin, Lisa Pedevillano, Lakshmi Munnangi, Asma Siddiqui, Daniel O’Dea, Larry Schek, Mike Jamal S. Rana, Heidi Gransar, Nathan D. Wong, Alan Rozanski, Sean Yen, Julie Ling, Larry Solomon, The Heart Center, Poughkeepsie, NY Hayes, Louise Thompson, John Friedman, Leslee J. Shaw, Daniel S. Learning Objective: Assess the value of Ct coronary calcium scores Berman, Cedars-Sinai Medical Center, Los Angeles, CA in high risk populations Learning Objective: Identify that addition of CAC but not multiple biomarkers,m substantially improves the risk stratification for CVD 1042-252 Do Gender Differences in Atherosclerotic plaque beyond that of established risk factors. Composition Persist with Aging? A Quantitative Non Invasive Assessment by Coronary CT Angiography 1041-247 Accuracy of Non-enhanced Cardiac Computed Tomography to detect myocardial infarcts. Ali Masud, Gudrun Feuchtner, Daniel Jodocy, Guy Friedrich, Roger S. Blumenthal, Matthew J J. Budoff, Khurram Nasir, Albert Einstein College Imaging and Diagnostic Testing Imaging and Diagnostic Mohit Gupta, Jigar Kadakia, Amish Patel, Naser Ahmadi, Taeyoung of Medicine, Bronx, NY, John Hopkins University, Baltimore, MD Choi, Gregg Yamada, Matthew Budoff, Los Angeles Biomedical Learning Objective: Evaluate for gender difference in plaque Research Institute at Harbor-UCLA, Torrance, CA

Learning Objective: identify the role of calcium scans to detect 1042-253 Influence of Viewing and Image Reconstruction myocardial infarcts as compared to myocardial perfusion imaging. Parameters on Diagnostic Accuracy, Image Quality, and Reader Confidence at Myocardial Stress 1041-248 Coronary Artery Calcification and Thoracic Aortic Computed tomography Perfusion Wall Calcification are Associated With Increasing Categories of Blood Pressure Brian B. Ghoshhajra, Tust Techasith, Nicola Drzezga, Ian S. Rogers, Hector Medina-Zuluaga, Ron Blankstein, Pal Maurovich-Horvat, Leif Heidi Gransar, Jamal S. Rana, Nathan D. Wong, Prediman K. Shah, C. Engel, Thomas J. Brady, Ricardo C. Cury, Massachusetts General Alan Rozanski, Sean Hayes, John Friedman, Louise Thomson, Daniel Hospital, Boston, MA, Baptist Cardiac and Vascular Institute, Miami, FL S. Berman, Cedars-Sinai Medical Center, Los Angeles, CA Learning Objective: describe the effects that different viewing and Learning Objective: demonstrate that advanced stages of image reconstruction parameters have on the diagnostic accuracy hypertension are associated with a higher likelihood of coronary and perceived image quality of stress CT perfusion. artery calcification, suggesting need for blood pressure control. JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A73

1042-254 Patient and Scan Variables Contributing to Diagnostic 1088-191 Near-term Post-test Treatment, Functional Status Accuracy of Coronary Computed Tomography and Resource Utilization In Intermediate Risk Angiography As Interpreted on an iPhone: Results Individuals With Stable Chest Pain Syndrome from the Multicenter ACCURACY Trial Undergoing 64-Detector Row Coronary Computed Tomographic Angiography Versus Myocardial Troy LaBounty, Robert J. Kim, Fay Y. Lin, Matthew J. Budoff, Jonathan Perfusion SPECT: A Prospective Multicenter W. Weinsaft, James K. Min, Cornell Medical College, New York, NY, Los Angeles Biomedical Research Institute and Harbor-UCLA, Randomized Trial Torrance, CA Fay Lin, Sunaina Koduru, Jason H. Cole, Jerome L. Hines, Troy M. Learning Objective: Indentify factors that impact the diagnostic Labounty, Jonathan W. Weinsaft, Tracy Q. Callister, Leslee J. Shaw, performance of coronary CT angiography on a handheld device. Daniel S. Berman, James K. Min, Weill-Cornell Medical Center, New York City, NY 1042-255 Combination of Coronary Artery Calcium and Learning Objective: describe downstream outcomes of initial Coronary CT Angiography for the Diagnosis of evaluation of chest pain by cardiac computed tomographic Obstructive Coronary Artery Disease angiography versus myocardial perfusion SPECT

Bradley S. Messenger, Yasmin Hamirani, Irfan Zeb, Matthew J. Defining Incremental Prognostic Value Of Exercise Budoff, Los Angeles Biomedical Research Institute at Harbor-UCLA 1088-192 Electrocardiography Combined With Multidetector Medical Center, Torrance, CA Coronary Computed Tomography In Patients With Learning Objective: Evaluate the diagnostic accuracy of combining Suspected Coronary Artery Disease coronary calcium scores with coronary computed tomographic angiography findings for coronary artery stenosis. Jaemin Shim, Hyuck-Jae Chang, Sung Woo Kwon, Dong-Won Kang, Mee-Eun Han, Young-Jin Kim, Byung-Wook Choi, Yangsoo Jang, Namsik Chung, Severance Hopsital, Seoul, South Korea 1088 CT CORONARY ANGIOGRAPHY AND POST Learning Objective: define incremental prognostic value of exercise RESOURCE UTILIZATION electrocardiography combined with multidetector coronary computed Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. tomography Georgia World Congress Center, Hall B5 Resource Utilization and Cardiac Risk Factor Presentation Hour: 3:30 p.m. - 4:30 p.m. 1088-193 Management One Year after Coronary Computed Imaging and Diagnostic Testing CME/CE Hours: 1 Tomography Angiography

Meagan K. Murphy, Khurram Nasir, Quynh Truong, Suhny Abbara, 1088-188 Impact of Coronary CT Angiography on the Behavior G. Scott Gazelle, Thomas J, Brady, Ron Blankstein, Massachusetts of Physicians and Patients in an Asymptomatic General Hospital, Boston, MA, Brigham and Women’s Hospital, Population Boston, MA

John W. McEvoy, Johns Hopkins Hospital, Baltimore, MD, Yonsei Learning Objective: Identify patients in whom coronary CTA will University Health System, Seoul, South Korea impact subsequent management

Learning Objective: Evaluate the impact on referral for secondary Rates of Invasive Coronary Angiography, tests, adverse cardiovascular events, and medication use of 1088-194 Revascularization and Patient Outcomes after incorporating coronary CT angiography (CCTA) into a cardiac screening program Computed Tomographic Coronary Angiography Benjamin J. W. Chow, Yeung Yam, George A. Wells, Terrence Ruddy, 1088-189 Temporal Change in Cardiovascular Risk in Patients University of Ottawa Heart Institute, Ottawa, ON, Canada with Non-Obstructive Plaque on CTA. Learning Objective: Understand the downstream implications of CTA Joanne D. Schuijf, Jacob M. van Werkhoven, Bernard A. Herzog, Aju Pazhenkottil, J Wouter Jukema, Eric Boersma, Ernst E. van der 1088-195 Spatial Clustering of Non-obstructive Plaque and Wall, Philipp A. Kaufmann, Jeroen J. Bax, Leiden University Medical All-cause mortality: A Prospective Multicenter Center, Leiden, The Netherlands, University Hospital Zurich, Zurich, Observational Cohort Study of 3,330 Symptomatic Switzerland Patients Undergoing 64-Detector Row Coronary Learning Objective: The current study demonstrates that Computed Tomographic Angiography cardiovascular risk of patients with non-obstructive plaque on CTA changes over time Fay Lin, Daniel S. Berman, Leslee J. Shaw, Sunaina Koduru, Israel Guerrero, Troy LaBounty, Jin-Ho Choi, Jonathan W. Weinsaft, Augustin J. Delago, Tracy Q. Callister, James K. Min, Weill-Cornell Medical Center, New York City, NY Learning Objective: Understand the interaction of coronary plaque burden and plaque distribution on mortality outcomes A74 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1089 CT CORONARY ANGIOGRAPHY: DIAGNOSTIC 1089-201 Combined Coronary Artery Calcium Scoring is ACCURACY II No more Beneficial than Current Standard of 64- row Multi-slice CT Angiography in Patients with Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Suspected Coronary Artery Disease Georgia World Congress Center, Hall B5 Sung Woo Kwon, Hyuk-Jae Chang, Jaemin Shim, Dong Won Kang, Mi Presentation Hour: 3:30 p.m. - 4:30 p.m. Eun Han, Young Jin Kim, Byoung Wook Choi, Yangsoo Jang, Namsik CME/CE Hours: 1 Chung, Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, South Korea

1089-197 Diagnostic Power of Multi-Detector Computed Learning Objective: Our study demonstrated that combined coronary Tomography for Detecting Patients with Obstructive artery calcium is no more beneficial than current standard of 64- Coronary Artery Disease Is Not Influenced by Severe row multislice CT angiography in patients with suspected coronary artery disease. Coronary Arterial Calcification - The CorE-64 Study Armin Arbab-Zadeh, Julie M. Miller, Carlos E. Rochitte, Marc Dewey, 1089-203 Validation of an Anatomic Measure Of Coronary Hiroyuki Niinuma, Ilan Gottlieb, Narinder Paul, Melvin E. Clouse, Stenosis With Computed Tomography Angiography Edward Shapiro, John Hoe, Albert C. Lardo, David E. Bush, Albert to Predict Hemodynamic Significance of Disease deRoos, Christopher Cox, Jeffrey Brinker, Joao A C Lima, Johns Defined by Flow Quantification Using Rubidium-82 Hopkins University, Baltimore, MD Positron Emission Tomography Learning Objective: To understand the diagnostic accuracy of MDCT Maria C. Ziadi, Paul Galiwango, Robert A. deKemp, Yeung Yam, to detect coronary artery disease in presence of severe coronary Terrence D. Ruddy, Rob SB Beanlands, Benjamin JW Chow, calcification University of Ottawa Heart Institute, Ottawa, ON, Canada

1089-198 Does An Abnormal Carotid Ultrasound Test Learning Objective: Distinguish coronary lesions with a functional Predict Coronary Atherosclerosis in Asymptomatic significance Subjects? 1089-204 Preoperative Coronary Angiography with Hooman Madyoon, Brittany E. Yee, Norman Lepor, Lili Sadri, Philip Multidetector CT is a Safe Alternative to Invasive Bretsky, Prediman K. Shah, Westside Medical Associates of Catheterization in Patients Undergoing Mitral Valve Los Angeles, Los Angeles, CA, Cedars-Sinai Medical Center, Los Repair Angeles, CA Javier G. Castillo, Gonzalo Pizarro, Leticia Fernandez-Friera, Valentin Learning Objective: To determine the accuracy with which carotid Fuster, David H. Adams, Mario J. Garcia, Javier Sanz, The Mount ultrasound findings predict the presence or absence of coronary Sinai Medical Center, New York City, NY atherosclerosis detected by non-invasive 64 slice CT angiography Learning Objective: Evaluate the effciacy, reliability of CT 1089-199 Value of Family History of Premature Coronary angiography in patients undergoing mitral valve repair Artery Disease as a Predictor of Obstructive Coronary Artery Disease on Coronary CT 1090 CT CORONARY ANGIOGRAPHY: INSIGHTS INTO Angiography, The ACIC Registry PLAQUE IMAGING Joao L. Cavalcante, Kavitha Chinnaiyan, Gilbert Raff, Mouaz H. Al-Mallah, The Advanced Cardiovascular Imaging Consortium Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Imaging and Diagnostic Testing Imaging and Diagnostic Investigators, Henry Ford Hospital - Heart & Vascular Institute, Georgia World Congress Center, Hall B5 Detroit, MI, William Beaumont Hospital, Royal Oak, MI Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: Demonstrates the significance of family history CME/CE Hours: 1 of premature CAD as an independent predictor for obstructive CAD 1090-205 Association of Aortic Valve Calcification and Mitral 1089-200 Diagnostic Accuracy of 64 slice Multidetector Annular Calcification to Noncalcified Coronary Coronary Computed Tomographic Angiography for Atherosclerotic Lesion Assessed by 64-multidetector Evaluation of Coronary Artery Stenosis in Persons Computed Tomography with Diabetes as Compared with Non- Diabetics Hiroto Utsunomiya, Hideya Yamamoto, Eiji Kunita, Norihiko Ohashi, Mohit Gupta, Yalcin Hacioglu, Naser Ahmadi, James Min, Faye Lin, Toshiharu Oka, Ryo Yamazato, Takenori Okada, Tomoki Shokawa, Matthew Budoff, Los Angeles Biomedical Research Institute at Yukiko Nakano, Hiroki Teragawa, Futoshi Tadehara, Takafumi Ishida, Harbor-UCLA, Torrance, CA Jun Horiguchi, Yasuki Kihara, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan Learning Objective: identify the role of coronary computed tomographic angiography for evaluation of coronary artery stenosis Learning Objective: identfy patients with advanced coronary in patients with diabetes atherosclerotic lesions by non-enhanced computed tomography JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A75

1090-206 Impact of Type 2 Diabetes on Coronary 1090-212 Evaluation of Plaque Morphology by 64-Slice Atherosclerosis Related to Vulnerable Plaque in Computed Tomographic Angiography Compared to Asymptomatic Patients Without Coronary Artery Intravascular Ultrasound in Non-Occlusive Segments Calcification Using Multislice Computed Tomography of Coronary Arteries

Kenji Harada, Akihiro Saito, Takanobu Okumura, Norihito Kageyama, Manoj Kesarwani, Taeyoung Choi, Lily Honoris, David M. Shavelle, Takashi Yamamoto, Hiroyuki Fujinaga, Tokushima Prefectural Central Matthew J. Budoff, Los Angeles Biomedical Research Center at Hospital, Tokushima, Japan Harbor-UCLA Medical Center, Torrance, CA Learning Objective: identify that complication of type 2 diabetic Learning Objective: Describe the statistical relationships associated relates to coronary atherosclerosis without coronary calcification, with the use of coronary computed tomographic angiography for and that not diabetes but hypertension influenced the presence of plaque characterization in non-occlusive coronary artery segments. vulnerable plaque

CT CORONARY ANGIOGRAPHY 1090-208 Association Between Cardiovascular Risk Factors 1091 and the Presence and Extent of Coronary Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Atherosclerotic Plaque Detected by Multislice Georgia World Congress Center, Hall B5 Computed Tomography Coronary Angiography Presentation Hour: 3:30 p.m. - 4:30 p.m. hikmet yorgun, Ergün B. Kaya, Tuncay Hazırolan, Ahmet H. AteƔ, CME/CE Hours: 1 Sercan Okutucu, UŒur Canpolat, Hamza Sunman, Hakan Aksoy, Kadri M. Gürses, Kudret Aytemir, Giray Kabakçı, Lale TokgözoŒlu, 1091-214 Cost-Effectiveness of Alternative Diagnostic Hilmi Özkutlu, Ali Oto, Hacettepe University, Ankara, Turkey Evaluation Pathways for Individuals with Stable Learning Objective: Patients with a low risk due to FRS or SCORE, Chest Pain Syndrome without Known Coronary had a significant percent of coronary artery plaque, which may Artery Disease necessiate cardiovascular risk reduction strategies on an individual James Min, Amanda Gilmore, Fay Y. Lin, Daniel S. Berman, MD, basis. Leslee J. Shaw, Erica M. Jones, Ken O’Day, Weill Cornell Medical College, New York, NY, Xcenda Corporation, Palm Harbor, FL 1090-209 Increased Epicardial Adipose Tissue as a Predictor of Coronary Low Density Plaque, Using Learning Objective: To understand cost-effectiveness of diagnostic 64-multidetector Computed Tomography strategies for coronary artery disease. Imaging and Diagnostic Testing Toshiharu Oka, Hideya Yamamoto, Eiji Kunita, Hiroto Utsunomiya, 1091-215 Coronary CT Angiography Based Predictors of Ryo Yamazato, Norihiko Ohashi, Toshiro Kitagawa, Takenori Okada, Myocardial Ischemia Detected by SPECT-MPI Tomoki Shokawa, Yukiko Nakano, Hiroki Teragawa, Futoshi Tadehara, Takafumi Ishida, Jun Horiguchi, Yasuki Kihara, Department of Balaji Tamarappoo, Ariel Gutstein, Victor Cheng, Ryo Nakazato, Heidi cardiovascular Medicine, Hiroshima University Graduate School of Gransar, Louise Thomson, Sean Hayes, John Friedman, Damini Dey, Biomedical Sciences, Hiroshima, Japan Piotr Slomka, Daniel Berman, Cedars Sinai Medical Center, Los Angeles, CA Learning Objective: demonstrate Learning Objective: describe the predictors of ischemia based on 1090-210 Frequency and Distribution of CT-based Vulnerable coronary CT angiographic findings Plaques 1091-216 Family history of Premature CAD and Traditional Makoto Kondo, Takeshi Kondo, Akitsugu Ohida, Hiroshi Fukazawa, Clinical Risk Factors In Predicting Obstructive Takahide Kodama, Tadaaki Orihara, Shinichi Takase, Jagat Narula, Coronary Atherosclerosis In Young Patients referred Takase Clinic, Takasaki, Japan for Coronary CT Angiography Learning Objective: identify frequency and distribution of CT-based vulnerable plaques. Aiden Abidov, Kavitha M. Chinnaiyan, James H. Wegner, Gilbert L. Raff, William Beaumont Hospital, Royal Oak, MI, Sarver Heart Center, Universtiy of Arizona, Tucson, AZ 1090-211 Outcomes of Patients Stratified Prospectively by Atherosclerotic Disease Burden Quantified by Learning Objective: Identify importance of the family history of Cardiac Computed Angiography premature CAD as a powerful predictor of significant CAD in young patients referred for coronary CTA Sanjay Gill, Marian F. Manankil, Tony Pallan, Claudius Mahr, Jerome L. Hines, Sorin C. Danciu, Advocate Illinois Masonic Medical Center, 1091-217 Practicability of Low-Dose CT Coronary Angiography Chicago, IL with Prospective ECG-Triggering Learning Objective: Demonstrate predictive value of CCTA Ronny R. Buechel, Aju P. Pazhenkottil, Bernhard A. Herzog, Lars Husmann, René N. Nkoulou, Irene A. Burger, Ines Valenta, Philipp A. Kaufmann, University Hospital Zurich, Zurich, Switzerland Learning Objective: Identify low-dose CT coronary angiography with prospective ECG-triggering as a practicable tool in daily clinical routine A76 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1091-218 Epicardial Adipose Tissue as a Predictor of 1092-224 Real-time Three-dimensional Echocardiography Coronary Atherosclerosis Without Calcification For A Comprehensive Pre-operative Assessment Using Multislice Computed Tomography in Elderly Of Heart Failure Patients With Left Ventricular Patients Aneurysm: Validation Study With Magnetic Resonance Imaging Kenji Harada, Akihiro Saito, Takanobu Okumura, Norihito Kageyama, Takashi Yamamoto, Hiroyuki Fujinaga, Tokushima Prefectural Central Nina Ajmone Marsan, Jos J M Westenberg, Stijntje D. Roes, Claudia Hospital, Tokushima, Japan Ypenburg, Rutger J. van Bommel, Victoria Delgado, Rob J. van der Geest, Robert J. Klautz, Johan C. Reiber, Martin J. Schalij, Jeroen J. Learning Objective: identify that measurements of epicardial Bax, Leiden Univeristy Medical Center, Leiden, The Netherlands fat volume is useful marker for the presence of CAD without calcification in elderly patients Learning Objective: to evaluate patients with LV aneursym with RT3DE in case MRI is not available 1091-220 The Potential of 64-slice Multidetector Computed Tomography Coronary Angiography to Replace 1092-225 Mitral Annular Area: Accuracy of Single and Biplane Invasive Coronary Angiography - the Ontario Linear Measurements Compared to 3D Planimetry Multidetector Computed Tomography Coronary Eiichi Hyodo, Rebecca T. Hahn, Shunichi Homma, Linda Gillam, Angiography Study (OMCAS) Columbia University, New York, NY Michael Richard Freeman, Ben Chow, James Bowen, Ron Goeree, Learning Objective: interpret OMCAS, University of Toronto, Toronto, Canada, Programs for Assessment of Technology in Health, Hamilton, Canada 1092-226 Real-time 3D Ultrasound to MR Image Fusion Can Learning Objective: Determine the patient population best suited for Guide Catheter-Based Cardiac Procedures MDCT coronary angiography Charles R. Hatt, III, Amish N. Raval, Ameet Jain, Vijay Parasarathy, Myocardial Bridging Does Not Increase Cardiac University of Wisconsin, Madison, WI, Philips Research, Briarcliff 1091-221 Manor, NY Risk in Patients with Chest Pain But no Obstructive Coronary Disease: A 64 Slice Coronary CT Learning Objective: evaluate a novel ultrasound-MRI based image Angiography Study fusion system and identify its potential applications.

Ronen Rubinshtein, Tamar Gaspar, Basil S. Lewis, Abhiram Prasad, Nathan Peled, David A. Halon, Lady Davis Carmel Medical Center, 1093 ECHOCARDIOGRAPHY: THREE-DIMENSIONAL Haifa, Israel, Mayo Clinic, Rochester, MN IMAGING OF THE RIGHT HEART Learning Objective: Evaluate the association between myocardial Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. bridging (on coronary CTA) and outcomes Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. 1092 CLINICAL APPLICATIONS OF THREE- CME/CE Hours: 1 DIMENSIONAL ECHOCARDIOGRAHPY 1093-228 Validation of 3-Dimensional Echocardiography in Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Quantification of Right Ventricular Volume: An In- Georgia World Congress Center, Hall B5 Vitro Study

Imaging and Diagnostic Testing Imaging and Diagnostic Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 David J. Sahn, Keith DesRochers, Zhiwen Zhou, Li Xiong, Muhammad Ashraf, Oregon Health & Science University, Portland, OR 1092-222 How Do the Linear Dimensions Contribute to Left Learning Objective: understand 3D quantification of the right Atrial Enlargement: A Real-Time Three-Dimensional ventricle Echocardiographic Study 1093-229 Accuracy of Right Ventricular Volumes and Function Gui Hua Yao, Leng Jiang, Baystate Medical Center, Tufts University Determined by 3-Dimensional Echocardiography in School of Medicine, Springfield, MA Comparison with Magnetic Resonance Imaging: A Learning Objective: identify that LA linear dimensions correlate Meta-Analysis Study logarithmically with LA volume and increase equally as LA enlarges, but their increases are significantly blunted when LA is severely enlarged. Yuichi J. Shimada, Takahiro Shiota, Beth Israel Medical Center, New York, NY, Cedars-Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 1092-223 The Added Value of Real-Time Three Dimensional Transesophageal Echocardiography in Catheter- Learning Objective: identify existence and extent of underestimation based, Percutaneous Left Atrial Appendage of right ventricular volumes and ejection fraction by 3-dimeisonal Obliteration by the Watchman device. echocardiography, the 10-year trend and factors affecting the systematic bias. Adam H. Skolnick, Simon Biner, Gila Perk, Robert J. Siegel, Roberto Lang, Lissa Sugeng, Bradley Knight, Larry Chinitz, Itzhak Kronzon, New York University, New York, NY, University of Chicago, Chicago, IL Learning Objective: Describe the utility of real-time 3D TEE in the evaluation of percutaneous left atrial appendage occlusion device placement JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A77

1093-230 Prediction Of Clinical Deterioration In Idiopathic 1094-235 Automated Contour Correction with Instantaneous Pulmonary Arterial Hypertension: Longitudinal Real-Time 3D-Volume Transthoracic Change In Right Ventricular Remodelling With Real Echocardiography Improves Accuracy of Left Time 3d Echocardiography And Cardiac Magnetic Ventricular Volume Measurements in Patients with Resonance. Systolic Dysfunction: Comparison to Cardiac MRI

IOULIA A. GRAPSA, David Dawson, Declan O’Regan, Giuliana Paaladinesh Thavendiranathan, Shizhen Liu, Bogdan Georgescu, Durighel, Petros Nihoyannopoulos, Hammersmith Hospital, London, Adrien Ntinunu, Anna Calleja, David Verhaert, Helene Houle, Thomas United Kingdom Van Houten, Joel Mancina, Nathalie De Michelis, David Orsinelli, Mary Ellen Orsinelli, Subha Raman, Thomas Ryan, Mani Vannan, Learning Objective: To describe the effect of right ventricular The Ohio State University, Columbus, OH, Siemens Healthcare, remodeling- as studied with 3D echocardiography and Cardiac Ultrasound, Mountain View, CA MRI - on clinical deterioration of idiopathic pulmonary arterial hypertensive patients. Learning Objective: To understand that automated virtual contour adjustment improves accuracy of LV volume measurements using 1093-231 Vortex Flow Formation in Patients after Tetralogy of real-time 3D-voulume transthoracic echocardiography in patients Fallot Repair with Pulmonary Regurgitation Utilizing with LV dysfunction 3-Dimensional Phase Encoded Velocity Mapping - A Clue To Power Loss, Poor Exercise Performance and 1094-236 Changes in Aortic-Mitral Coupling with Severe Aortic Better Surgery Stenosis

Mark A. Fogel, Kartik Sundareswaran, Matthew Harris, Elizabeth Wendy Tsang, Lissa Sugeng, Federico Veronesi, Valluvan Goldmuntz, Ajit Yoganathan, Childrens Hospital of Philadelphia, Jeevanandam, Jai Raman, Lynn Weinert, Roberto M. Lang, University Philadelphia, PA, Georgia Institute of Technology, Atlanta, GA of Chicago Medical Centre, Chicago, IL Learning Objective: Describe the flow disturbances in the RVOT in Learning Objective: Describe the changes to the aortic and mitral TOF pts and the clinical implications. valves with severe aortic stenosis.

Automated 3-D Quantification of Left Ventricular 1093-232 Real-Time 3D Echocardiographic Imaging of the 1094-237 Tricuspid Valve: Visualization Rates in Consecutive Volumes and Ejection Fraction in Atrial Fibrillation Patients by Transthoracic Real-Time Volume Imaging

Amit Pursnani, Patrick Coon, Lynn Weinert, Georgeanne Lammertin, Shizhen Liu, Bogdan Georgescu, Adrien Nitnunu, Thomas Van Imaging and Diagnostic Testing Heidi Pollard, Victor Mor-Avi, Roberto M. Lang, Lissa Sugeng, New Houten, Helene Houle, Nathalie De Michelis, Anna Calleja, Mary York University Medical Center, New York, NY, University of Chicago Ellen Orsinelli, Peng Li, Paaladinesh Thavendiranathan, Thomas Hospitals, Chicago, IL Ryan, Mani Vannan, The Ohio State University, Columbus, OH, Siemens Medical Solutions, Mountain View, CA Learning Objective: Undertstand the role of Real-Time 3D Echo in visualization of the tricuspid valve Learning Objective: Measure 3D LV systolic function in Afib

1094-238 Real-Time Three-Dimensional Quantitative 1094 ECHOCARDIOGRAPHY: THREE-DIMENSIONAL Echocardiography Assessment of Right and Left ECHOCARDIOGRAPHY IN LEFT VENTRICULAR Ventricular Mass in Healthy Human Fetuses FUNCTION David J. Sahn, Minjuan Zheng, Michael Schaal, Xiaokui Li, Weihui Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Shentu, Mary E. Joyce, Muhammad Ashraf, Oregon Health & Georgia World Congress Center, Hall B5 Science University, Portland, OR Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: understand development of the fetal heart CME/CE Hours: 1 1095 CT CORONARY CALCIUM AND NONCORONARY CT 1094-234 Accuracy of Left Ventricular Volumes and Function APPLICATIONS Determined by 3-Dimensional Echocardiography Validated by Magnetic Resonance Imaging: A Meta- Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Analysis and Investigation for the Source of Bias Georgia World Congress Center, Hall B5 Yuichi J. Shimada, Takahiro Shiota, Beth Israel Medical Center, New Presentation Hour: 3:30 p.m. - 4:30 p.m. York, NY, Cedars-Sinai Medical Center, Los Angeles, CA CME/CE Hours: 1 Learning Objective: identify existence, extent and factors of Coronary Calcium Progression Predicts All Cause underestimation in left ventricular volumes and ejection fraction 1095-239 measured by 3-dimensional echocardiography Mortality Matthew J. Budoff, John E. Hokanson, Khurram Nasir, Leslee J. Shaw, Gregory L. Kinney, David Chow, Daniel DeMoss, Vivek Nuguri, Vahid Nabavi, Raghu Ratakonda, Daniel S. Berman, Paolo Raggi, Los Angeles Biomedical Research Institute, Torrance, CA, Emory University, Atlanta, GA Learning Objective: To understand implications of coronary calcium progression A78 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1095-240 Absence of Abdominal Aortic Calcium Is Associated 1096-246 A Catenoid Configuration is Associated Strongly with Low Prevalence of Obstructive Coronary with Regional Strain Properties in Patients with Disease Hypertrophic Cardiomyopathy

Bryan Zweig, Steve Simpson, Darshan C. Patel, Mouaz H. Al-Mallah, kazuhisa nishimura, Hideki Okayama, Katsuji Inoue, Makoto Saito, Henry Ford Heart and Vascular Institute, Detrioit, MI Toyofumi Yoshii, Go Hiasa, Takumi Sumimoto, Takayuki Nagai, Jun Suzuki, Akiyoshi Ogimoto, Tomoaki Ohtsuka, Junichi Funada, Jitsuo Learning Objective: Improve methods of risk stratification for Higaki, Ehime University Graduate School of Medicine, Toon, Ehime, patients evaluted for coronary artery disease. Japan, Department of Cardiology, Kitaishikai Hospital, Ozu, Ehime, Japan 1095-241 Head-to-Head Comparison of Coronary Calcium Imaging, Computed Tomography Coronary Learning Objective: interpret an impact of septal catenoid Angiography and Exercise Testing in Real-World configuration in patients with HCM Patients with Stable Chest Pain 1096-247 Advanced Feature Tracking on 4D Echo Images Koen Nieman, Tjebbe Galema, Lisan Neefjes, Annick Weustink, Paul Defines Anterior, Septal and Apical Dysfunction Musters, Adriaan Moelker, Pim De Feyter, Erasmus MC, Rotterdam, in Open Chest Pigs Subjected to Intermittent LAD The Netherlands Occlusion Learning Objective: identify the need and means for further testing David J. Sahn, Muhammad Ashraf, Berkley Cameron, Bill Kenny, of symptomatic patients depending on the CT coronary calcium Oregon Health & Science University, Portland, OR, Toshiba America scan results. Medical Systems, Tustin, CA

1095-242 Relationships of Mitral Annular Calcification to Learning Objective: understand use of 3D echo Cardiovascular Risk Factors: The Multi-ethnic Study of Atherosclerosis (MESA) 1096-248 Three-Dimensional Radial, Circumferential and Longitudinal Speckle-Tracking Strain to Quantify Somsupha Kanjanauthai, Khurram Nasir, Ronit Katz, Juan J. Dyssynchrony Rivera, Junichiro Takasu, Roger S. Blumenthal, John Eng, Matthew J. Budoff, Medical College of Georgia, Augusta, GA, Los Angeles Hidekazu Tanaka, Olusegun Oyenuga, Phillip Habib, Samir Saba, Biomedical Research Institute at Harbor-UCLA Medical Center, John Gorcsan, III, University of Pittsburgh, Pittsburgh, PA Torrance, CA Learning Objective: demonstrate that 3-D speckle-tracking radial, Learning Objective: To evaluate relationships between MAC and circumferential and longitudinal strain can successfully quantify measured CVD risk factors in an ethnically diverse population dyssynchrony. without clinically apparent CVD 1096-249 Cardiac Twist by Two-Dimensional and Three- 1095-243 Prevalence and Severity of Atherosclerosis in Young Dimensional Echocardiography: An in Vitro Persons With Diabetes Comparison Study

Nikhil A. Daga, Khurram Nasir, Yasmin Hamirani, John Tayek, Philip David J. Sahn, Karen Li, Shiza Ashraf, Sarah Yang, Max Carlson, Bach, Matthew Budoff, Harbor UCLA Medical Center, Torrance, CA, Colleen Newey, Li Xiong, Zhiwen Zhou, Muhammad Ashraf, Oregon Los Angeles Biomedical Cardiovascular Computed Tomography Core Health & Science University, Portland, OR Laboratory, Torrance, CA Learning Objective: understand 3D methods of assessing heart

Imaging and Diagnostic Testing Imaging and Diagnostic Learning Objective: Identify that a major percentage of Diabetics < function 40 years 1. Have detectable coronary atherosclerosis. 2. Are at a 4-6 fold higher risk for presence of significant CAC. 3. May benefit from a statin. 1097 ECHOCARDIOGRAPHY OF THE LEFT ATRIUM Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. 1096 THREE-DIMENSIONAL/TWO- DIMENSIONAL Georgia World Congress Center, Hall B5 ECHOCARDIOGRPAHY IN MYOCARDIAL Presentation Hour: 3:30 p.m. - 4:30 p.m. FUNCTION CME/CE Hours: 1 Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. 1097-251 Role of Left Atrial Reservoir Dysfunction in Georgia World Congress Center, Hall B5 Pathophysiology of Diastolic Heart Failure Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 Hidemichi Kouzu, Satoshi Yuda, Junichi Nishida, Naohiro Funayama, Atsushi Mochizuki, Maki Ichimura, Takahiro Doi, Hitomi Yamamoto, Atsuko Muranaka, Nobuaki Kokubu, Noriyuki Fujii, Three-Dimensional Strain Assessment of Rotational 1096-245 Shinya Shimoshige, Mamoru Hase, Akiyoshi Hashimoto, Kazufumi Shear within an In Vitro Pulsatile Balloon Heart Tsuchihashi, Naoki Watanabe, Kazuaki Shimamoto, Sapporo Model with Two Layers of Rotation Medical University School of Medicine, Sapporo, Japan David J. Sahn, Thomas L. Tee, Uyen T. Truong, Keith DesRochers, Learning Objective: evaluate the risk of developing heart failure in Muhammad Ashraf, Oregon Health & Science University, Portland, OR patients with diastolic dysfunction. Learning Objective: understand deformation imaging JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A79

1097-252 Is Mitral Annulus Early Diastolic Velocity a Clinically 1143-191 Poor Blood Pressure Response to Exercise Predicts Relevant Index of left Ventricular Relaxation? Adverse Prognosis in Patients with Non-Ischemic but not Ischemic Cardiomyopathy Zoran Popovic, IV, Milind Y. Desai, Adisai Buakhamsri, Chirapa Puntawagkoon, Allen Borowski, Benjamin D. Levine, Wai Hong Yusuke Sata, Hiroshi Takaki, Rika Kawakami, Michio Nakanishi, Wilson Tang, James D. Thomas, Cleveland Clinic, Cleveland, OH, Michio Nakanishi, Teruo Noguchi, Yoichi Goto, Masaru Sugimachi, University of Texas Southwestern Medical Center Dallas, Dallas, TX National Cardiovascular Center, Suita, Japan, Department of Cardiovascular Dynamics, National Cardiovascular Center Research Learning Objective: understand the determinants of early diastolic Institute, Suita, Japan velocity of mitral annulus Learning Objective: prognostic impact of cardiopulmonary exercise 1097-253 Mitral Annular Motion Contributes Left Atrial Filling During Systole By Providing Interactive Relationship 1143-192 Overweight Is Associated with Dynamic Arterial Between Left Ventricular And Left Atrial Function Stiffening During Exercise in Non-diabetic Women: Implication on Exercise Intolerance Sung Hee Shin, Sang Don Park, Seong Il Woo, Dae Hyeok Kim, Keum Soo Park, Woo Hyung Lee, Jun Kwan, Inha University Hospital, Chi Young Shim, Sungha Park, Donghoon Choi, Woo-In Yang, In- Incheon, South Korea Jeong Cho, Namsik Chung, Jong-Won Ha, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, South Korea Learning Objective: evaluate the impact of the geometric change of the MA during systole on the left atrial filling Learning Objective: identify the dynamic arterial stiffening during exercise and it is associated with exercise intolerance in overweight 1097-254 Transesophageal Echocardiography and DC women. Cardioversion: 10 Years Experience in Over 2700 Patients 1143-193 Anemia and Abnormal Ventilatory Response to Exercise Predict Adverse Clinical Outcomes in Tristan B. Klosterman, Hirad Yarmohammadi, Kevin Shrestha, Chronic Heart Failure Brandon Varr, Bruce Lindsey, Andrew Zurich, Wai Hong W. Tang, Allan L. Klein, Cleveland Clinic, Cleveland, OH Takamasa Sato, Tomofumi Misaka, Akiomi Yoshihisa, Yasuchika Takeishi, Department of Cardiology and Hematology, Fukushima Learning Objective: Evaluate the continuing clinical application Medical University, Fukushima, Japan of transesophageal echocardiography prior to direct current cardioversion in patients with atrial fibrillation. Learning Objective: Demonstrate that combination of VE/VCO2 slope and hemoglobin concentration can identify high risk patients Imaging and Diagnostic Testing 1097-255 Transesophageal Echocardiography Confirms in chronic heart failure Validity of CHADS2 Score in Atrial Flutter 1143-194 Inability of Different Modalities of Stress Testing Milind Parikh, Zaid Aziz, Richard G. Trohman, Kousik Krishnan, Rush in Predicting Coronary Artery Disease in Obese University Medical Center, Chicago, IL Subjects Learning Objective: Evaluate the validity of the CHADS2 risk score in atrial flutter Anitha Rajamanickam, Samir Kapadia, Rubin Bahuva, Thadeo Catacutan, Alraies Chadi, Ali Usmani, Sam Butler, Stephen Ellis, James B. Young, Manuel Cerqueira, Cleveland Clinic, Cleveland, OH 1143 EXERCISE PHYSIOLOGY AND RISK FACTORS FOR Learning Objective: To identify the best modality of Stress testing in CARDIOVASCULAR DISEASE the obese patients Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Exaggerated Hypertensive Response to Exercise Georgia World Congress Center, Hall B5 1143-195 in the Early Stages of Hypertension: Relationships Presentation Hour: 9:30 a.m. - 10:30 a.m. with Indices of Arterial Stiffness CME/CE Hours: 1 Dimitris Tsiachris, Konstantinos Tsioufis, Dimitris Roussos, 1143-188 Additive Effect of Cardiorespiratory Fitness Level Anastasia Mazaraki, Eirini Andrikou, Ioannis Andrikou, Andreas and Adiposity on Mortality in Patients with Coronary Michaelides, Christodoulos Stefanadis, First Cardiology Clinic, Artery Disease University of Athens, Hippokration Hospital, Athens, Greece Learning Objective: demonstrate the association of exaggerated Kashish Goel, Randal J. Thomas, Ray W. Squires, Virend K. Somers, blood pressure response during exercise with adverse John M. Miles, Francisco Lopez-Jimenez, Mayo Clinic, Rochester, MN cardiovascular adaptations in the setting of uncomplicated Learning Objective: Recognize the joint impact of cardiorespiratory essential hypertension fitness and adiposity on mortality in coronary artery disease patients.

1143-189 Direct Association Between Serum Vitamin D Level and Cardiorespiratory Fitness in Healthy Adults.

Afrooz Ardestani, Beth Parker, Shishir Mathur, Priscilla Clarkson, Linda Pescatello, Donna Polk, Paul D. Thompson, Henry Low Heart Center, Hartford Hospital, Hartford, CT, University of Connecticut, School of Medicine, Farmington, CT Learning Objective: Determine the relationship between serum Vitamin D level and cardiorespiratory fitness in healthy adults. A80 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1144 RELATIONSHIP OR FUNCTIONAL CAPACITY TO 1144-203 Exercise Training Improves LV Mass, LV End MORPHOLOGY AND HEMODYAMICS Diastolic Volume and Stroke Volume and Reduces Upright Heart Rate in the Postural Orthostatic Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Tachycardia Syndrome Georgia World Congress Center, Hall B5 Paul S. Bhella, Tiffany B. VanGundy, Qi Fu, Benjamin D. Levine, The Presentation Hour: 9:30 a.m. - 10:30 a.m. Institute of Exercise and Environmental Medicine at Texas Health CME/CE Hours: 1 Resources, Dallas, TX, The University of Texas-Southwestern, Dallas, TX

Does Physical Functioning as Assessed by Short Learning Objective: The impact of exercise training on the disorder 1144-197 POTS (Postural Orthostatic Tachycardiac Syndrome) Form Health Survey Predict Peak Oxygen Uptake in Patients With Atrial Septal Defect Type Secundum? 1144-204 Aortic Root Dimensions in Elite Athletes Alexander Van De Bruaene, Roselien Buys, Luc Vanhees, Philip Antonello D’Andrea, Rosangela Cocchia, Lucia Riegler, Rodolfo Citro, Moons, Werner Budts, University Hospitals, Leuven, Belgium Olga Vriz, Pio Caso, Raffaele Calabrò, Eduardo Bossone, Second Learning Objective: evaluate perceived health status and its relation University of Naples - Ao Monaldi, Naples, Italy, Department of to peak oxygen consumption in ASD patients Cardiac Surgery, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San, Milan, Italy 1144-198 Does Exercise Always Cause Physiological Learning Objective: Our objective was to explore the full range of Hypertrophy? aortic root diameters in elite athletes. Maria Schoepe, Andrea Schrepper, Michael Schwarzer, Paulo Amorim, Friedrich W. Mohr, Torsten Doenst, University of Leipzig 1145 CT CORONARY ANGIOGRAPHY: DIAGNOSTIC Heart Center, Leipzig, Germany ACCURACY I Learning Objective: evaluate exercise induced hypertrophy with different intensity protocols associated with impairment in cardiac Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. function, reduced respiratory capacity and pathological alterations Georgia World Congress Center, Hall B5 in gene expression. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1144-199 Marathon Runners Have Increased Aortic Stiffness Despina Kardara, Charalambos Vlachopoulos, Aris Anastasakis, 1145-205 Patient Factors Predictive of Uninterpretable Katerina Baou, Dimitrios Terentes-Printzios, Ioanna Dima, Georgios Results in Cardiac Computed Tomographic Antoniou, Athanasios Gravos, Christodoulos Stefanadis, 1st Angiography Cardiology Department, Athens Medical School, Hippokration Thomas E. Vanhecke, Ryan D. Madder, Patricia A. Peyser, Kavitha Hospital, Athens, Greece Chinnaiyan, William Beaumont Hospital, Royal Oak, MI Learning Objective: evaluate cardiovascular risk in marathon Learning Objective: To predict factors predictive of uninterpretable runners focusing on the proper training volumes, frequency and results on coronary computed tomography angiography in duration symptomatic patients Impact of Physical Fitness on Echocardiographic 1144-200 Quantitative and Diagnostic Accuracy of 64-MDCTA Left Ventricular Mass in Healthy Young Black and 1145-206

Imaging and Diagnostic Testing Imaging and Diagnostic for Segmental Coronary Artery Stenosis Detection: White Adult Men and Women: The Coronary Artery Results from The CORE-64 Multicenter International Risk Development in Young Adults (CARDIA) Study Study Eveline Oestreicher, Elyse Foster, Celina M. Yong, Stephen Sidney, Julie M. Miller, Carlos E. Rochitte, Marc Dewey, Hiroyuki Niinuma, Kofo O. Ogunyankin, Kirsten Bibbins-Domingo, University of Armin Arbab-Zadeh, Ilan Gottlieb, Narinder Paul, Melvin E. Clouse, California, San Francisco, San Francisco, CA Edward Shapiro, John Hoe, David E. Bush, Albert Lardo, Albert de Learning Objective: recognize how physical fitness in early Roos, Christopher Cox, John Texter, Andrea Vavere, Joao A. Lima, adulthood may impact left ventricular mass Jeffery Brinker, Johns Hopkins University, Baltimore, MD, InCor Sao Paulo Heart Institute, Sao Paulo, Brazil Life-long Patterns of Physical Activity Determine 1144-201 Learning Objective: Interpret the segment based diagnostic Exercise Capacity and Cardiac Function accuracy of MDCTA, in comparison with the patient-based accuracy. Naoki Fujimoto, Paul S. Bhella, Shigeki Shibata, Jeff Hastings, Nicole Minniefield, Dean Palmer, Benjamin D. Levine, Institute for 1145-208 Quantitative Computed Tomography Coronary Exercise and Environmental Medicine, Texas Health Presbyterian Angiography is Highly Accurate in the Detection Hospital Dallas, Dallas, TX, The University of Texas Southwestern of Flow-Limiting Coronary Arterial Stenoses as Medical Center at Dallas, Dallas, TX Assessed by Fractional Flow Reserve

Learning Objective: identify that subjects with the highest amount Sarah Rinehart, Dimitri Karmpaliotis, Charlie Brown, Anna Kalynich, of lifelong endurance exercise training had the greatest exercise Zhen Qian, Gustavo Vazquez, Idean Marvasty, Szilard Voros, capacity due to a larger stroke volume and cardiac outut at peak Piedmont Heart Institute, Atlanta, GA exercise. Learning Objective: Understand CT parameters that accurately predict obstructive FFR JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A81

1145-209 Accuracy of Non-Invasive Multislice Computed 1146-215 Impact of Exercise Capacity Beyond Anaerobic Tomography Coronary Angiography; Detection Threshold of Significant Stenosis versus Detection of Mahoto Kato, Lynne W. Stevenson, Greg Flaker, L. Howard Hartley, Atherosclerosis Brigham and Women’s Hospital, Boston, MA Joella E. Velzen, Joanne D. Schuijf, Fleur R. de Graaf, Gabija Learning Objective: The ability to exercise beyond anaerobic Pundziute, Fabrizio Spano, Jacob M. van Werkhoven, Martin J. threshold may be an important additional point of interpretation of Schalij, Lucia J. Kroft, Albert de Roos, Johannes H. Reiber, J. Wouter metabolic exercise testing results. Jukema, Ernst E. van der Wall, Jeroen J. Bax, Leiden University Medical Centre, Leiden, The Netherlands 1146-216 Exercise Hyperventilation and Central Sleep Learning Objective: to understand that MSCT coronary angiography Apnea in Heart Failure Patients: Relationship to is superior in detection of the presence of atherosclerosis rather Neurohumoral activation than the detection of precise degree of stenosis Andrew D. Calvin, Virend K. Somers, Christelle van der Walt, Jennifer M. Fitz-Gibbon, Lyle J. Olson, Mayo Clinic, Rochester, MN 1145-210 Relationship of Coronary Artery Plaque Composition to Coronary Artery Stenosis Severity: Results from Learning Objective: describe the association between the Prospective Multicenter ACCURACY Trial norepinephrine, endothelin-1, central sleep apnea, and hyperventilation James Min, Michael Edwardes, Fay Y. Lin, Troy M. Labounty, Nina Koduru, Jonathan W. Weinsaft, Jin-Ho Choi, Augustin Delago, Leslee Reversal Of Respiratory Muscles Dysfunction And J. Shaw, Daniel S. Berman, Matthew J. Budoff, Weill Cornell Medical 1146-217 Exercise Capacity Improvement After Continuous- College, New York, NY, Harbor UCLA Medical Center, Los Angeles, CA flow Left Ventricular Assist Device Implantation Learning Objective: To understand the relationship between plaque composition and stenosis severity Stavros Dimopoulos, Georgios Tzanis, Athanasios Tasoulis, Anthi Mpouchla, Christos Manetos, Nikolaos Diakos, Eleni Tseliou, Iraklis Pozios, Lambros Katsaros, Serafim Nanas, 1st Critical Care 1145-211 Evaluation of Chronic Total Occlusion by Multi- Detector Computed Tomography: Comparison Medicine Dept, Cardiopulmonary Exercise Testing and Rehabilitation Laboratory,NKUA, Athens, Greece, 3rd Cardiology “Laiko” Hospital, with Intravascular Ultrasound Imaging after NKUA, Athens, Greece, Athens, Greece Recanalization Learning Objective: Demonstrate the reversal of respiratory muscles

Akiko Maehara, Michael Poon, Gary S. Mintz, Kazuhiro Ashida, dysfunction and exercise capacity improvement after continuous- Imaging and Diagnostic Testing Hisaya Sato, Masahiko Ochiai, Cardiovascular Research flow left ventricular assist device implantation Foundation/Columbia University Medical Center, New York, NY, Showa University Northern Yokohama Hospital, Yokohama, Japan 1146-218 A Novel Method for Measuring Exercise Oscillatory Learning Objective: evaluation of morphology of chronic total Ventilation Among Heart Failure Patients occlusion by multi-detector row computed tomography Andrew D. Calvin, Christopher G. Scott, Jennifer M. Fitz-Gibbon, Lyle J. Olson, Mayo Clinic, Rochester, MN 1145-212 Mechanism of Improvement in Mitral Regurgitation in the Acute Phase after Cardiac Resynchronization Learning Objective: describe exercise oscillatory ventilation Therapy 1146-220 Relation of Exercise Oscillatory Ventilation to Michio Imai, Katsuomi Iwakura, Atsunori Okamura, Yasushi Koyama, Cardiac Remodeling and Hemoglobin Level in Motoo Date, Yoshiharu Higuchi, Koichi Inoue, Ryusuke Kimura, Patients with Idiopathic Dilated Cardiomyopathy Hiroyuki Nagai, Yuko Toyoshima, Makito Ozawa, Norihisa Ito, Yukinori Okazaki, Masahiko Shibuya, Shigemiki Omiya, Takashi Takagi, Takahiro Okumura, Akihiro Hirashiki, Yuji Kono, Jun Kojima, Satoru Daisuke Morisawa, Kenshi Fujii, Cardiovascular Center,Sakurabashi- Ohshima, Kyosuke Takeshita, Xian Wu Cheng, Akiko Noda, Sumio Watanabe Hospital, Osaka, Japan Yamada, Toyoaki Murohara, Department of Cardiology, Nagoya Learning Objective: learn a mechanizm of improvement in severe MR. University Graduate School of Medicine, Nagoya, Japan Learning Objective: clarify the contribution of cardiac remodeling to exercise oscillatory ventilation in patients with idiopathic dilated 1146 EXERCISE PHYSIOLOGY AND VENTILATORY cardiomyopathy. FACTORS Obesity Paradox: Influence Of Age And Weight Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. 1146-221 Changes On All-cause Mortality Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Kusum Lata, Paul McAuley, Jonathan Myers, J. Pittsley, Victor CME/CE Hours: 1 Froelicher, Cardiology Division, Veterans Affairs Palo Alto Health Care System/Stanford University, Palo Alto, CA 1146-214 Determinants of Exercise Oscillatory Ventilation in Learning Objective: Demonstarte effect of age and weight changes Heart Failure to mortality

Ravi V. Shah, Ryan Murphy, Paul Pappagianopoulos, David Systrom, Marc Semigran, Gregory Lewis, Massachusetts General Hospital, Boston, MA Learning Objective: To describe critical relationships between central hemodynamics and exercise oscillatory ventilation in patients with chronic systolic heart failure A82 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1147 MRI: CMR - CLINICAL 1148 MRI: VASCULAR IMAGING Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1147-222 Incidence of New Valvular Dysfunction in Normal 1148-228 Impaired Coronary Vascular Reactivity in Cardiac Subjects Over Five Years: A Prospective Study Syndrome X Measured Non-Invasively by 3T MRI

Dipti Gupta, Jing Han, Nathaniel Reichek, St Francis Hospital, Tonia Yee, Alice Chang, Melanie Kotys, Elizabeth Holper, Ron Roslyn, NY, University of Iowa, Iowa City, IA Peshock, UT Southwestern, Dallas, TX Learning Objective: Identify the increased incidence of new Learning Objective: Understand the potential of 3T MRI for moderate valvular dysfunction in a healthy middle aged cohort as measuring impairment in coronary vascular reactivity in women at recognised by cardiac imaging modalities. risk for cardiovascular disease.

1147-223 Diagnostic Usefulness of Edema-infarct ratio to 1148-229 Impact of Disease Etiology on Aortic Stiffness Differentiate Acutely from Chronically Damaged Determined by Cardiovascular Magnetic Resonance: Myocardium Using Magnetic Resonance Imaging a Cohort Study of Patients with Aortic Pathology

Kiyoyasu Yamada, Isobe Satoshi, Kousuke Kinoshita, Susumu Andrew To, Ruvin S. Gabriel, Zoran B. Popovic, Rahul Renapurkar, Suzuki, Kazuhiko Yokouchi, Hirokazu Iwata, Ken Sawada, Makoto Michael Bolen, Scott D. Flamm, Brian P. Griffin, Milind Y. Desai, Hirai, Gifu Social Insurance Hospital, Kani, Japan, Nagoya University Cleveland Clinic Foundation, Cleveland, OH Graduate School of Medicine, Nagoya, Japan Learning Objective: identify the important determinants of pulse Learning Objective: The edema-infarct ratio of LV area is a useful wave velocity measured by cardiovascular magnetic resonance in index in detecting the stage of patients with acute myocardial various aortic pathologies infarction. 1148-230 Relationship between Coronary and Brachial Artery 1147-224 Prognostic Value of Right Ventricular Ejection Endothelial Function in Normal and Abnormal Fraction Determined by Cardiac Magnetic Subjects Resonance Hariharan Subramanian, Yi Wang, William Schapiro, Kathy McGrath, Ijaz Ahmad, Aziz Rehman, Joe Y. Lau, Betty Hua, Frida Ashurova, Simcha Pollack, Nathaniel Reichek, St.Francis Hospital, Roslyn, NY, Geetha Bhumireddy, Faisal Ali, Charles Vu, Joshua Fogel, Sorin Division of Cardiology, SUNY Stony Brook, Stony Brook, NY J. Brener, Terrence Sacchi, John F. Heitner, New York Methodist Learning Objective: Understand the relationship between Hospital, Brooklyn, NY endothelial function in coronary and peripheral vascular beds Learning Objective: Demonstrate the prognostic value of right and also demonstrate a direct non invasive method of evaluating ventricular ejection fraction coronary vasomotion

1147-225 Location Of Myocardial Fibrosis In Patients With 1148-231 Turner Syndrome Aortopathy Demonstrated by Hypertrophic Cardiomyopathy Detected By Cardiac Cardiac MRI-Determined Aortic Pulse Wave Velocity

Imaging and Diagnostic Testing Imaging and Diagnostic Magnetic Resonance Imaging Is Related To Various Sean Hagenbuch, Kan N. Hor, Wojciech Mazur, Robert J. Fleck, Electrocardiographic Changes Phillipe Backeljauw, D Woodrow Benson, William M. Gottliebson, Bong Gun Song, Ga Yeon Lee, Eun Kyung Kim, Hye Jin Han, Dong Janaka Wansapura, Cincinnati Children’s Hospital Medical Center, Ryeol Ryu, Sung-A Chang, Sung-Ji Park, Jin-Oh Choi, Sang-Chol Lee, Cincinnati, OH Seung Woo Park, Yeon Hyeon Choe, Jae K. Oh, samsung medical Learning Objective: Distinguish Turner syndrome aortopathy as a center, seoul, South Korea unique entity, and describe a novel technique for measuring MRI Learning Objective: We demonstrated the characteristics of LGE and derived aortic pulse wave velocity assessed relationships between ECG findings and LGE in patients with hypertrophic cardiomyopathy 1148-232 Hyperintense Coronary Plaque on Non-Contrast T1-Weighted Cardiac Magnetic Resonance Is 1147-226 Apical Hypokinesis is a Sensitive Marker of Associated with Carotid Artery Inflammation Early Right Ventricular Dysfunction in Pulmonary Evaluated by [18F]-Fluorodeoxyglucose Positron Hypertension. Emission Tomography

Leticia A. Fernandez-Friera, Ana Garcia-Alvarez, Ajith Nair, Gabriela Atsushi Tanaka, Tomohiro Kawasaki, Teruo Noguchi, Yoshihiro Guzman, Alaitz Romero, Juan Gaztanaga, Valentin Fuster, Mario Hiramatsu, Takaya Fukuyama, Nobuhiko Koga, Teruo Inoue, Koichi Garcia, Javier Sanz, Mount Sinai Hospital, New York, NY Node, koga Hospitai 21, Kurume, Japan Learning Objective: Identify apical right ventricle dysfunction in Learning Objective: identify not only high-risk coronary plaque, pulmonary hipertension patients before global right ventricular but also a severity carotid artery inflammation, by using cardiac systolic function is reduced, using cardiac magnetic resonance magnetic resonance imaging. JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A83

1149 MRI: APPLICATIONS IN ELECTROPHYSIOLOGY 1149-238 Impact of Extent of Myocardial Fibrosis on Occurrence of Ventricular Tachyarrhythmia in Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Hypertrophic Cardiomyopathy: Results from MRI Georgia World Congress Center, Hall B5 with Late Gadolinium Enhancement Study in Presentation Hour: 9:30 a.m. - 10:30 a.m. Genotyped Patients CME/CE Hours: 1 Junichiro Yokawa, Eiichi Masuta, Noboru Fujino, Kenshi Hayashi, Katsuharu Uchiyama, Akira Funada, Yuichiro Sakamoto, Toshinari 1149-234 Assessment of the Left Atrial Substrate in Lone Tsubokawa, Akihiko Muramoto, Hidekazu Ino, Masakazu Yamagishi, Atrial Fibrillation: Implications for Staging of Atrial Kanazawa University, Kanazawa, Japan Fibrillation Learning Objective: demonstrate that CMR-determined myocardial Nathan Burgon, Troy J. Badger, Nazem W. Akoum, Gaston Vergara, fibrosis could be indicative of VT. Lori McMullan, Yaw A. Adjei-Poku, Thomas S. Haslam, Jeremy Fotheringham, Eugene G. Kholmovski, Rob S. MacLeod, Nassir F. Marrouche, University of Utah Health Sciences Ctr, Salt Lake City, UT 1150 MRI: CARDIOMYOPATHIES - RISK STRATIFICATION & OUTCOMES Learning Objective: Distinguish the term ‘lone’ AF as not appropriately categorizing AF patients based on LA substrate Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. analysis & staging AF based on extent of substrate disease may be Georgia World Congress Center, Hall B5 a more accurate way to classify AF. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1149-235 Evaluation of the Left Atrial Substrate and Age in Atrial Fibrillation Patients using Delayed- ® Enhancement MRI 1150-239 Iron Chelation Therapy with Deferasirox (Exjade ) in Reducing Cardiac Siderosis in β-Thalassemia Thomas S. Haslam, Troy J. Badger, Nazem W. Akoum, Gaston Patients: 2-Year Results from the EPIC Cardiac Vergara, Lori McMullan, Yaw A. Adjei-Poku, Nathan S. Burgon, Kevin Substudy Tek, Eugene G. Kholmovski, Nassir F. Marrouche, University of Utah, Comprehensive Arrhythmia and Research Management Center, Salt Dudley J. Pennell, John Porter, Domenica Cappellini, Lee Lee Chan, Lake City, UT Amal El-Beshlawy, Yesim Aydinok, Hishamshah Ibrahim, Chi-Kong Li, Vip Viprakasit, Mohsen Elalfy, Antonis Kattamis, Gillian Smith, Dany Learning Objective: Describe that substrate analysis using DE-MRI

Habr, Gabor Domokos, Bernard Roubert, Ali Taher, Royal Brompton Imaging and Diagnostic Testing confirms that aging plays an integral component in LA remodeling in Hospital, London, United Kingdom AF patients. Learning Objective: UNderstand possible role of deferasirox for 1149-236 Cardiac Outcome after Cardiac Resynchronization treatment of cardiac siderosis Therapy Is Better Predicted by Late Gadolinium Enhancement Cardiac Magnetic Resonance than 1150-240 Can CMR be the ‘Crystal Ball’ for Patients with Left Ventricular Reverse Remodeling Dilated Cardiomyopathy? Risk Stratification for Cardiac Transplantation/LVAD Francisco Ridocci, Alfonso Valle, Jordi Estornell, Alesandro Pirola, Miguel Corbi, Javier Jimenez, Elena Lucas, Candela Rodriguez, Jose Vicente Venero, Srinivas Murali, Mark Doyle, Vikas K. Rathi, Juan J. Restrepo, Leandro Perez, Aurelio Quesada, Rafael Paya, Saundra B. Grant, June A. Yamrozik, Ronald B. Williams, Diane Consorcio Hospital General Universitari, Valencia, Spain A. Vido, Geetha Rayarao, Robert WW Biederman, The Center for CVMRI, The Gerald McGinnis Cardiovascular Institute at Allegheny Learning Objective: identify late gadolinium enhanced cardiac General Hospital, Pittsburgh, PA magnetic resonance as predictor of long term outcome after cardiac resynchronization therapy irrespective of left ventricular remodeling Learning Objective: To understand the potential for a single image via CMR to effectively and accurately risk-stratify dilated cardiomyopathy and to predict LVAD/transplant requirements 1149-237 Scar Morphology In Patients Presenting with Ventricular Arrhythmias: Implications for Risk Stratification in Patients with Chronic Ischemic 1150-241 Cardiac Sarcoidosis with Preserved Systolic Cardiomyopathy Function: Impact of Late Gadolinium Enhancement on Diastolic Function and Left Atrial Morphology Jaimie Manlucu, Lorne J. Gula, Mohammed Al-Admawi, Raymond Yee, Andrew Krahn, Allan Skanes, George Klein, Nowell Fine, Amit R. Patel, Michael R. Klein, Nadera J. Sweiss, Kirk T. Spencer, Terry Thompson, Maria Drangova, James A. White, London Health Jeanne M. DeCara, Roberto M. Lang, Lissa Sugeng, Stephen L. Sciences Corporation, London, ON, Canada, University of Western Archer, D. Kyle Hogarth, Martin C. Burke, Timothy B. Niewold, John F. Ontario, London, ON, Canada Beshai, University of Chicago, Chicago, IL Learning Objective: describe the emerging role of scar morphology, Learning Objective: Understand the relationship between cardiac as identified by LGE MRI, in the risk stratification of patients with sarcoidosis and diastolic function. chronic myocardial infarction A84 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1150-242 Late Gadolinium Enhancement by Cardiac Magnetic 1151-248 Echocardiographic Dyssynchrony Predicts Survival Resonance Can Predict the non-Responders to Following Cardiac Resynchronization Therapy β-blocker in Patients with Dilated Cardiomyopathy Phillip J. Habib, Olusegun Oyenuga, Hidekazu Tanaka, Stephanie Shiro Nakamori, Tairo Kurita, Takashi Tanigawa, Kei Sato, Hiroshi Haberman, Evan C. Adelstein, John Gorcsan, III, University of Nakajima, Yasutaka Ichikawa, Koji Matsuoka, Katsuya Onishi, Pittsburgh, Pittsburgh, PA Hajime Sakuma, Masaaki Ito, Matsusaka Central Hospital, Learning Objective: Demonstrate that the absence of echo Matsusaka, Japan, Mie University Hospital, Tsu, Japan dyssynchrony was predictive of a significantly less favorable Learning Objective: The CMR LGE predicts the non-responders event-free survival outcome following CRT than the presence of to optimal therapy including beta-blockers and may provide new dyssynchrony. risk stratification strategies (i.e.,determining the need for device therapy) in DCM patients. 1151-249 The Impact of Apical Imaging Level on Echocardiographic Measurement of Left Ventricular 1150-243 Degree of Mitral Regurgitation and Left Ventricular Torsion: The Need for Standardization Scarring Are Much Better Predictors of Long-term Outcomes Compared to Volumes and Sphericity: Rory B. Weiner, Michael H. Picard, Jonathan Kim, Ari D. Brettman, Arthur E. Weyman, Aaron L. Baggish, Massachusetts General A Multi-modality Imaging Study in Patients with Hospital, Boston, MA Severe Ischemic Cardiomyopathy Learning Objective: Describe the impact of standardized apical Deborah Kwon, Zoran B. Popovic, Venugopal Menon, Carmel M. imaging level on echocardiographic measurement of left ventricular Halley, Danielle M. Brennan, Randall C. Starling, Scott D. Flamm, torsion. Paul Schoenhagen, Bruce W. Lytle, Brian P. Griffin, Milind Y. Desai, Milind Y. Desai, Cleveland Clinic, Cleveland, OH 1152 MRI: NEW DEVELOPMENTS IN CMR Learning Objective: To demonstrate that left ventricular sphericity is not an independent predictor of mortality in ICM Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 1151 MRI: CORONARY ARTERY DISEASE - DIAGNOSIS Presentation Hour: 9:30 a.m. - 10:30 a.m. & PROGNOSIS CME/CE Hours: 1

Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. 1152-251 Reinfarction-Specific Magnetic Resonance Imaging Georgia World Congress Center, Hall B5 Contrast Agent Presentation Hour: 9:30 a.m. - 10:30 a.m. Robert Kirschner, Akos Varga-Szemes, Levente Toth, Tamas Simor, CME/CE Hours: 1 Pal Suranyi, Balazs Ruzsics, Pal Kiss, Attila Toth, Robert Baker, Brigitta C. Brott, Silvio Litovsky, Ada Elgavish, Gabriel A. Elgavish, 1151-245 The Prognostic Value Of Dobutamine Cardiovascular University of Alabama at Birmingham, Birmingham, AL, Elgavish Magnetic Resonance In Patients With Known Or Paramagnetics Inc., Hoover, AL Suspected Cad. Learning Objective: recognize the potential usefulness of the Sebastian Kelle, Christoph Klein, Amedeo Chiribiri, Juliane Vierecke, presented method in future clinical practice for differentiate Christina Egnell, Ingo Paetsch, Cosima Jahnke, Ernst Wellnhofer, between acute and older myocardial infarcts, and list the most Eckart Fleck, German Heart Institute Berlin, Berlin, Germany common clinical scenarios Imaging and Diagnostic Testing Imaging and Diagnostic Learning Objective: interpret dobutamine induced wall-motion- Gadonanotubes as Magnetic Nanolabels: A abnormalities at DCMR. 1152-252 Powerful and Safe Approach for Stem Cell Detection 1151-246 Feasibility and Early Prognostic Data on Treadmill Exercise Magnetic Resonance Imaging Stress Lesa A. Tran, Ramkumar Krishnamurty, Maria G. Cabreira-Hansen, Testing Raja Muthupillai, Lon J. Wilson, Guilherme Silva, James T. Willerson, Emerson P. Perin, Texas Heart Institute, Houston, TX, Rice University, Brandon C. Drafts, Pairoj Rerkpattanapipat, Timothy M. Morgan, Houston, TX Craig A. Hamilton, William Ntim, W. Gregory Hundley, Wake Forest University School of Medicine, Winston-Salem, NC Learning Objective: Evaluate gadonanotubes as a powerful and safe T1-weighted MRI contrast agent Learning Objective: Evaluate the feasibility and prognostic utility of treadmill exercise cardiac magnetic resonance imaging stress A Non-Invasive MR Speckle Tracking Study of testing. 1152-253 Myocardial Strain and Rotational Velocity in Patients with Congenital Heart Disease 1151-247 Detection of Myocardial Infarctions Early and Late After Heart Transplantation with Contrast-Enhanced David J. Sahn, Petra S. Niemann, Helene Houle, Craig S. Broberg, MRI Michael Silberbach, Zhiwen Zhou, Muhammad Ashraf, Oregon Health & Science University, Portland, OR, Siemens Medical Henning Steen, Grigorios Korosoglou, Nina Riedle, Stephanie Solutions, Mountain View, CA Lehrke, Evangelos Giannitsis, Hugo A. Katus, University of Heidelberg, Heidelberg, Germany Learning Objective: understand strain and twist in biventricular malformations Learning Objective: distinguish between infarct-atypical and -typical late enhancement JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A85

1152-254 Left Ventricular Remodeling In Response To 1198-192 Acute Effects of Passive Smoking on Systolic and Pressure Load: Changes In Myocardial Fiber Diastolic Function and Pulmonary Artery Stiffness Architecture As Assessed By Diffusion MRI in Healthy Volunteers

Kaitlyn M. Lam, Van Weeden, Jose-Luis Guerrero, Xin Zeng, Claudia Mehmet Kaya, Ibrahim Ozdogru, Ibrahim Gul, Ali Dogan, Tugrul Inanc, Chae, Judy Hung, Massachusetts General Hospital, Boston, MA Mikail Yarlioglues, Nihat Kalay, Mehtap Ozdogru, Ramazan Topsakal, Namik K. Eryol, Abdurrahman Oguzhan, Erciyes University, Kayseri, Turkey Learning Objective: identify architectural changes associated with LV remodeling in response to hypertension Learning Objective: Passive smoking has no effect on systolic function but has a subtle effect on diastolic function. However, 1152-255 Detection of Increased Left Ventricular Filling passive smoking has prominent effect on pulmonary stiffness. Pressure by Cardiovascular Magnetic Resonance 1198-193 Detection of Myocardial Amyloid Involvement Using Tariq M. Alhogbani, Oliver Strohm, Matthias Friedrich, Stephenson 2-Dimentional Speckle Tracking Echocardiography: cardiac MRI center, University of Calgary, Calgary, AB, Canada Utilization of Inner and Outer Myocardial Strain and Learning Objective: evaluate atrial contraction contribution to Strain Rate left ventricular filling and detect elevated LV filling pressure by cardiovascular magnetic resonance Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Noriko Tomita, Keisuke Endo, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi 1198 GENERAL ECHOCARDIOGRAPHY: EVALUATION OF Akaike, Masataka Sata, The University of Tokushima, Tokushima, Japan CARDIAC FUNCTION Learning Objective: We evaluated whether an amyloid involvement could be identified by 2-dimentional speckle tracking Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. echocardiography. Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. 1198-194 Acute Effect of Atrial Fibrillation on Left Ventricular CME/CE Hours: 1 Longitudinal Function: Serial Observation by Speckle Tracking Echocardiography 1198-188 Applicability, Limitations and Impact of Echocardiography Utilization Based on the 2007 Jun Koyama, Hirohiko Motoki, Kazunori Aizawa, Megumi Koshikawa, Appropriateness Use Criteria for Transthoracic and Hiroki Kasai, Atsushi Izawa, Takeshi Tomita, Yusuke Miyashita,

Setsuo Kumazaki, Uichi Ikeda, Shinshu University Graduate School Imaging and Diagnostic Testing Transesophageal Echocardiography at a Tertiary of Medicine, Matsumoto, Japan Care Medical Center Learning Objective: learn longitidinal left ventricular dysfunction Jayanth Koneru, Mohammad Al Qarqaz, Karthikeyan during atrial fibrillation. Ananthasubramaniam, Henry Ford Hospital, Detroit, MI Learning Objective: Evaluate Applicability of 2006 Appropriate Use 1198-195 Relation of Myocardial Strain with Left Ventricular Criteria In Real World Utilization of Echocardiography, Impact on Geometry after Acute Myocardial Infarction Patient Management and to Identify Limitations of AUC Maria Louisa Antoni, Victoria Delgado, Jael Z. Atary, Eduard R. Holman, Ernst E. Van der Wall, Martin J. Schalij, Jeroen J. Bax, Rapid Quantification of Left Ventricular Ejection 1198-189 Leiden University Medical Center, Leiden, The Netherlands Fraction Using Echocardiographic Speckle Tracking of the Mitral Annular Plane Learning Objective: evaluate the relation between myocardial deformation and alterations in left ventricular geometry after acute Wendy Tsang, Sonal Chandra, Amit Patel, Lissa Sugeng, Ivan S. myocardial infarction. Salgo, Lynn Weinert, Victor Mor-Avi, Roberto M. Lang, University of Chicago Medical Centre, Chicago, IL 1199 GENERAL ECHOCARDIOGRAPHY: RIGHT HEART Learning Objective: Evaulate left ventricular ejection fraction using echocardiographic speckle tracking of mitral annular displacement. FUNCTION EVALUATION BY STRAIN Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. 1198-191 Echocardiographic Assessment of Left Ventricular Georgia World Congress Center, Hall B5 Diastolic Filling Pressure Predicts Primary Presentation Hour: 3:30 p.m. - 4:30 p.m. Cardiovascular Events in Older Adults CME/CE Hours: 1 Gustavo G. Blume, Marion E. Barnes, Patricia A. Pellikka, Stephen S. Cha, Teresa S.M. Tsang, Department of Echocardiography Mayo 1199-197 Impact of Acute Moderate Right Ventricular Clinic, Rochester, MN Overload on Peak Apical Left Ventricular Diastolic Learning Objective: Evaluate if left ventricular filling pressure Rotation Rate predicts cardiovascular outcomes Panupong Jiamsripong, Anna M. Calleja, Eun Joo Cho, Mohsen S. Alharthi, Eileen M. McMahon, Marek Belohlavek, Mayo Clinic Arizona, Scottsdale, AZ Learning Objective: Demonstrate increasing in peak apical diastolic LV rotation rate leads to the increase LV untwisting and represents a marker of the compensatory response of the LV to moderate RV pressure overload A86 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1199-198 Assessment of Right Ventricular Function with 1200 EXERCISETESTING FOR CORONARY ARTERY Longitudinal Two Dimensional Strain: Comparison DISEASE AND BEYOND between Low and Intermediate Risk Pulmonary Embolism Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Vincent DESCOTES GENON, Romain Chopard, Mathilde Morel, Joanna Dutheil, Nicolas Meneveau, Marie-France Seronde, Francois Presentation Hour: 3:30 p.m. - 4:30 p.m. Schiele, Yvette Bernard, Service de Cardiologie, BESANCON, France CME/CE Hours: 1

Learning Objective: evaluate right ventricule maximal systolic 2D Exercise Stress Test Results In Patients With longitudinal strain 1200-205 Bare Metal Stents Or Drug Eluting Stents: Pathophysiological And Clinical Implications 1199-199 Right Ventricular Strain Patterns in Patients with Pulmonary Hypertension. Gaetano A. Lanza, Roberto Nerla, Antonio Di Monaco, Gaetano Pinnacchio, Roberto Mollo, Cristina Aurigemma, Gregory A. Sgueglia, Mangeet Chahal, Steven Bruhl, Samer Khouri, University of Toledo Alfonso Sestito, Filippo Crea, Università Cattolica del Sacro Cuore, Medical Center, Toledo, OH Roma, Italy Learning Objective: Identify early changes in right ventricular Learning Objective: To evaluate the prognostic role of exercise remodeling secondary to pulmonary hypertension stress test in patients with PCI and coronary stent implantation First Documentation of Cardiac Dysfunction 1199-200 1200-206 Exaggerated Blood Pressure Response Is Following Exposure to the World Trade Center Accompanied by a State of Pronounced Disaster Albuminuria, Hypoadiponectinemia, Increased Lori B. Croft, Maryann McLaughlin, Jeffrey Bander, Andrew Goldberg, Asymmetric Dimethylarginine and Osteoprotegerin Andrew Krasner, William L. Duvall, Martin E. Goldman, Jacqueline Levels in Hypertension Moline, Mount Sinai Medical Center, New York, NY Konstantinos P. Tsioufis, Kyriakos Dimitriadis, Anastasia Mazaraki, Learning Objective: To evaluate evidence of cardiac involvement in Eirini Andrikou, Ioannis Andrikou, Athanasios Aggelis, Antigoni subjects exposed to the World Trade Center disaster Miliou, Andreas Michaelides, Christodoulos Stefanadis, First Cardiology Clinic, University of Athens, Hippokration Hospital, 1199-201 Prognostic Value of Right Ventricular Function in Athens, Greece Patients After Acute Myocardial Infarction Treated Learning Objective: describe the relationships of exercise with Primary Percutaneous Coronary Intervention hypertensive response with asymmetric dimethylarginine, Maria Louisa Antoni, Roderick W. Scherptong, Jael Z. Atary, Eric adiponectin, osteoprotegerin and albuminuria in hypertension Boersma, Eduard R. Holman, Ernst E. Van der Wall, Martin J. Schalij, Jeroen J. Bax, Leiden University Medical Center, Leiden, The 1200-208 Paced Rhythm at Baseline is Associated With Lower Netherlands Exercise Capacity in Heart Failure Learning Objective: evaluate the prognostic importance of right Amaar Ujeyl, Lynne W. Stevenson, Patricia Campbell, Mahoto Kato, ventricular function in patients after acute myocardial infarction. Daniel E. Forman, Brigham and Women’s Hospital, Boston, MA Learning Objective: consider the importance of heart rate reserve 1199-203 The Combination of Inferior Vena Cava and E/e’ in heart failure patients with baseline pacing to optimize functional Imaging and Diagnostic Testing Imaging and Diagnostic Is a Powerful Index of the Deterioration of Renal capacity Function and the Prognosis after a First ST- Elevation Acute Myocardial Infarction 1200-209 The Prognostic Utility of Exercise ECG Testing in Noriaki Iwahashi, Masami Kosuge, Jun Okuda, Kengo Tsukahara, Patients over 75 Years of Age with Angina Yoshio Tahara, Kiyoshi Hibi, Toshiaki Ebina, Shinichi Sumita, Kazuaki Jun R. Chiong, Tricia Aguilar, Mark Ghamsary, Loma Linda University Uchino, Toshiyuki Ishikawa, Satoshi Umemura, kazuo Kimura, School of Medicine, Loma Linda, CA, Loma Linda University School Division of Cardiology, Yokohama City University Medical Center, of Public Health, Loma Linda, CA Yokohama, Japan Learning Objective: Exercise capacity is a better predictor of Learning Objective: describe how to use of IVC size in patients with outcomes compared to ECG changes among 75 years and above a first STEMI referred for angina workup.

Bedside Ultrasound Assessment Of Right Atrial 1199-204 1200-210 Longitudinal Two-Dimensional Speckle Tracking Pressure: Relationship To Venous Compliance Indices on Rest Echocardiographic Images Predicts John J. Pacella, Christopher Defrancesco, Dustin E. Kliner, James Significant Coronary Disease P. Lynch, John P. Girod, Madhurmeet Singh, Flordeliza S. Villanueva, Kofo O. Ogunyankin, David E. Montgomery, Jyothy J. Puthumana, Marc A. Simon, University of Pittsburgh, Pittsburgh, PA Daniel J. Schuster, Northwestern University Feinberg School of Learning Objective: Understand how venous compliance dictates Medicine, Division of Cardiology, Chicago, IL the venous pressure-area relation Learning Objective: Understand diagnostic value of deformational characteristics of the LV JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A87

1200-211 Selection of Stress Modality as a Strong Marker 1201-217 Two-Dimensional Echocardiographic Aortic Root of Prognosis in 12,770 Patients with Suspected Dimensions in Adolescents and Adults: Normal Coronary Artery Disease Limits in Relation to Age, Body Size and Gender

Ramdas G. Pai, Padmini Varadarajan, Terence Lin, Loma Linda Richard B. Devereux, Giovanni de Simone, Donna K. Arnett, Lyle G. University Medical Center, Loma Linda, CA Best, Eric Boerwinkle, Barbara V. Howard, Dalane Kitzman, Elisa T. Lee, Thomas H. Mosley, Jr, Alan Weder, Mary J. Roman, Weill Cornell Learning Objective: To know the effect of type of stress test on Medical College, New York, NY survival Learning Objective: identify and understand factors associated with 1200-212 Improving the Specificity of Exercise Testing in aortic root size Women by High-Frequency QRS Analysis 1201-218 Differences of Effect by Valvular Surgery on David Rosenman, Yaakov Mogilevski, Shimon Abboud, Dan Tzivoni, Left Ventricular Systolic Function Assessed by Shaare Zedek Medical Center, Jerusalem, Israel, Tel-Aviv University, 2-Dimensional Speckle-Tracking Echocardiography Tel-Aviv, Israel between Aortic Regurgitation and Aortic Stenosis Learning Objective: Recognize the added value of high-frequency QRS analysis in diagnosing ischemic heart disease in women Hisao Yoshikawa, Makoto Suzuki, Takako Tsuchida, Tsukasa Osaki, Takenori Otsuka, Takayoshi Matsuyama, Hiromasa Yamashita, Makoto Uchida, Norio Uchimura, Shigeyuki Ozaki, Kaoru Sugi, Toho 1201 GENERAL ECHOCARDIOGRAPHY: CARDIAC university ohashi medical center, Tokyo, Japan FUNCTION, MASS, AND RESISTANCE BY Learning Objective: demonstrate ECHOCARDIOGRAPHY Development and Validation of Corrected Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. 1201-220 Pulmonary Vascular Resistance for Assessment Georgia World Congress Center, Hall B5 of Patients with Pulmonary Hypertension with Presentation Hour: 3:30 p.m. - 4:30 p.m. Echocardiography. CME/CE Hours: 1 Arun Dahiya, David J Holland, Christine Jellis, David Prior, Thomas Marwick, University of Queensland, Brisbane, Australia, St Vincent’s 1201-214 Correlation of N-Terminal Pro B-Type Natriuretic Peptide and Speckle Tracking Derived Longitudinal Hospital, Melbourne, Australia Strain in Severe Asymptomatic Aortic Stenosis Learning Objective: Nonivasively identify and monitor patients with Imaging and Diagnostic Testing elevated pulmonary vascular resistance. Jutta Bergler-Klein, Raphael Rosenhek, Harald Gabriel, Georg Goliasch, Gerald Maurer, Thomas Binder, Med. Univ. of Vienna, Plasma Copeptin (Carboxy-terminal Pro- Dept. of Cardiology, Vienna, Austria 1201-221 Vasopressin) is Associated with Left Atrial Size and Learning Objective: Interpret BNP and strain as early markers of LV Left Ventricular Mass Index in African American dysfunction in asymptomatic severe aortic stenosis Adults with Hypertension.

1201-215 Relationship Between Aortic Stiffness and Left Umer Saleem, Thomas Mosley, Jr., Nils G. Morgenthaler, Andreas Ventricular Systolic Function in Patients With Bergmann, Joachim Struck, Iftikhar J. Kullo, Mayo Clinic, Rochester, Normal Ejection Fraction: a Study by Tissue Doppler MN, University of Mississippi Medical Center, Jackson, MS and Strain Imaging Learning Objective: Describe the association of plasma copeptin, a surrogate for circulating AVP, with left atrial size and left venticular Cesare Russo, Yasuyoshi Takei, Takuya Hasegawa, Shun Koshaka, mass indexed to height in African American adults with hypertension. Shunichi Homma, Mitchell S.V. Elkind, Ralph L. Sacco, Marco R. Di Tullio, Columbia University, New York, NY, University of Miami, Miami, FL Learning Objective: Describe the relationship between aortic 1202 SPECT: RISK STRATIFICATION AND NEW AGENTS stiffness and subclinical left ventricular systolic function reduction Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Risk Factor Burden in Diabetic Adults With Known 1201-216 Presentation Hour: 3:30 p.m. - 4:30 p.m. Cardiovascular Disease Is Associated With Left Ventricular Hypertrophy and Dysfunction: The Strong CME/CE Hours: 1 Heart Study 1202-222 Beneficial Effects of Early Statin Treatment on Richard B. Devereux, Giovanni de Simone, Mary J. Roman, Elisa T. Microvascular Dysfunction and Left Ventricular Lee, Lyle G. Best, Barbara V. Howard, Weill Cornell Medical College, Remodeling in Patients with Acute Myocardial New York, NY, University of Oklahoma, Oklahoma City, OK Infarction Learning Objective: demonstrate the impact of CV risk factors on prognosis and preclinical CVD in diabetics without recognized CVD Kentarou Ishida, Tohru Geshi, Akira Nakano, Hiyoyasu Uzui, Yasuhiko Mitsuke, Naoki Amaya, Jyunji Sakata, Katsuhiko Sarasawa, Takehiko Satoh, Tetsuji Morishita, Kiwamu Murakami, Jong-Dae Lee, University of Fukui Hospital, Fukui, Japan Learning Objective: Early Statin treatment may provide beneficial effects in terms of attenuating LV remodeling after MI, which may be associated with improved global microvascular dysfunction. A88 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1202-223 Location Location Location: Does it Matter with Stress 1203-229 Comparison of Ability Stress Tests to Accurately SPECT Myocardial Perfusion Imaging Outcomes? Predict Specific Areas of Ischemia

Sabeena Arora, Shishir Mathur, Vivian Teixeira, Abhijit Ghatak, Anitha Rajamanickam, Samir Kapadia, Thadeo Catacutan, Alraies Mahjabeen Rashid, Sanjeev U. Nair, Fawad Kazi, Alan W. Ahlberg, Chadi, Ankita Satra, Amit Maranganti, Marwan Nasif, Anuradha Gary V. Heller, Hartford Hospital, Hartford, CT, University of Ramaswamy, Sam Butler, Stephen Ellis, Manuel Cerqueira, James B. Connecticut, Farmington, CT Young, Cleveland Clinic, Cleveland, OH Learning Objective: Determine whether location of a perfusion defect Learning Objective: To identify the ability of stress tests to imparts prognostic information independent of summed stress score. accurately predict the area of ischemia in obese patients with and without prior CABG 1202-224 The Significance of Transient Ischemic Dilation in the Setting of Otherwise Normal SPECT 1203-230 Impact of Type of Stress on Reduction In Perfusion Radionuclide Myocardial Perfusion Images Defect Size by Ranolazine in Patients with Coronary Artery Disease Carolina Valdiviezo, Apurva Motivala, Rory Hachamovitch, Murthy Chamarthy, Pablo Navarro, Robert J. Ostfeld, Mimi Kim, Mark Rajesh Venkataraman, Luiz Belardinelli, Brent Blackburn, Jaekyeong I. Travin, Montefiore Medical Center/Albert Einstein College of Heo, Ami Iskandrian, University of Alabama at Birmingham, Medicine, Bronx, NY, The Johns Hopkins Hospital, Baltimore, MD Birmingham, AL, Gilead, Palo Alto, CA Learning Objective: interpret the significance of TID in patients with Learning Objective: Describe the impact of exercise stress as otherwise normal SPECT myocardial perfusion imaging opposed to vasodilator stress in improving perfusion pattern by ranolazine in patients with CAD and myocardial ischemia 1202-225 Can Stress Single Photon Emission Computed Tomography Myocardial Perfusion Imaging 1203-231 Revascularization improves myocardial perfusion Provide Effective Cardiac Risk Stratification in abnormalities to a greater extent than medical Octogenarians with No Known Coronary Artery therapy in patients with coronary artery disease: Disease? Insights from the Nuclear Cardiology Databank and Duke Databank for Cardiovascular Disease Sanjeev U. Nair, Shishir Mathur, Abhijit Ghatak, Vivian Texeira, Mahjabeen Rashid, Fawad Kazi, Alan Ahlberg, Anuj Shah, Roger Harry R. Phillips, Linda Shaw, Mona Fiuzat, Christopher O’Connor, Mennett, Deborah Katten, Gary Heller, ; Henry Low Heart Center, Eric Velazquez, Salvador Borges-Neto, Duke University Medical Hartford Hospital, Hartford, CT, University of Connecticut School of Center, Durham, NC, Duke Clinical Research Institute, Durham, NC Medicine, Farmington, CT Learning Objective: To compare revascularization vs. medical Learning Objective: Define the role of stress SPECT myocardial therapy on perfusion imaging in patients with severe coronary perfusion imaging in cardiac risk stratification of patients aged 80 disease years and above. 1203-232 Gender-related Differences in Short-term Referral 1202-226 LMI1195: A New 18F Benzylguanidine Analog for Rates To Catheterization After Non-invasive Cardiac PET Cardiac Sympathetic Neuronal Imaging Imaging in Patients Without Known CAD: Results From the Study of Myocardial Perfusion and Ming Yu, Mary Guaraldi, Jody Bozek, Melanie Lamoy, Paula Silva, Mikhail Kagan, David Onthank, Mahesh Mistry, Joel Lazewatsky, Coronary Anatomy Imaging Roles in CAD (SPARC) Matthias Broekema, Heike Radeke, Ajay Purohit, Michael Azure, Marcelo F. Di Carli, James R. Johnson, Leslee J. Shaw, Mark A. Imaging and Diagnostic Testing Imaging and Diagnostic Richard Cesati, David Casebier, Simon Robinson, Lantheus Medical Hlatky, Rob Beanlands, Benjamin Chow, Elizabeth Branscomb, Imaging, N Billerica, MA Michael L. Ridner, John Lesser, Panithaya Chareonthaitawee, Subha Learning Objective: appreciate the better imaging profile of Raman, Szilard Voros, Daniel S. Berman, Barbara H. Johnson, this novel PET agent with high selectivity to the norepinephrine Mariya Gaber, Julie Williams, Rory Hachamovitch, Brigham and transporter for evaluation of cardiac neuronal function and its use Women’s Hospital, Boston, MA in HF stratification Learning Objective: Describe gender-related changes in referral to catheterization after cardiac imaging 1203 ASSESSMENT OF ISCHEMIA AND RESPONSE TO THERAPY WITH SPECT Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1

1203-228 Adenosine Stress Myocardial Perfusion Imaging in Low Risk Emergency Department Acute Chest Pain patients

Faisal Nabi, Su Min Chang, Elizabeth Gigliotti, John Mahmarian, Methodist DeBakey Heart and Vascular Center, Houston, TX Learning Objective: evaluate JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A89

1204 ASSESSING DYSSYNCHRONY WITH NUCLEAR 1205 IMAGING INFLAMMATION, NEURONAL TECHNIQUES INNERVATION AND METABOLISM Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1

1204-234 Left Ventricular Dyssynchrony by Phase Analysis is a 1205-239 Demonstration of Increased Aortic Valve Inflammation Predictor of Mortality in End-Stage Renal Disease in Aortic Stenosis using 18F-Fluorodeoxyglucose Positron Emission Tomography Himanshu Aggarwal, Fadi G. Hage, Wael Aljaroudi, Rajesh Venkataraman, Jaekyeong Heo, Ami E. Iskandrian, Division of Gergana N. Marincheva-Savcheva, Sadia Qadir, Thomas J. Brady, Cardiovascular Disease, University of Alabama at Birmingham, Ahmed Tawakol, Massachusetts General hospital, Boston, MA Birmingham, AL, Division of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, AL Learning Objective: evaluate inflammation in Aortic Stenosis using FDG-PET imaging, which may have an important implication in the Learning Objective: Identify Left Ventricular Dyssynchrony as design of studies assessing the effect of therapeutic agents on AS. Predictor of Mortality in End-Stage Renal Disease 1205-240 Impact of Age on Myocardial Uptake of I123-mIBG 1204-235 Relation of Left Ventricular Dyssynchrony by in Subjects without Heart Disease: Observations Phase Analysis of Gated SPECT Images and from the ADMIRE-HF Trial Cardiovascular Events in Patients with Implantable Cardiac Defibrillators. Ji Chen, Liudmila Verdes, Russell D. Folks, Daya N. Manatunga, Arnold F. Jacobson, Ernest V. Garcia, Emory University, Atlanta, GA, Wael AlJaroudi, Fadi Hage, Daniel Hermann, Harrish Doppalapudi, GE Healthcare, Princeton, NJ Jaekyeong Heo, Ami E. Iskandrian, University of Alabama at Learning Objective: Relationship between age and cardiac Birmingham, Birmimgham, AL, Birmingham Veteran’s Administration sympathetic neuronal uptake of I123-mIBG Medical Center, Birmingham, AL

Learning Objective: Left ventricular dyssynchrony by phase analysis 1205-241 Prognostic Implications of Cardiac Sympathetic of gated SPECT MPI is predictive of cardiovascular events in Innervation Assessed by MIBG in Heart Failure Imaging and Diagnostic Testing patients with implantable cardiac defibrillators. Patients with Preserved Left Ventricular Ejection Fraction 1204-236 Impact of Scar Burden by SPECT Perfusion Imaging and Echocardiographic Dyssynchrony on Long-Term Takahiro Doi, Naohiro Funayama, Junichi Nishida, Atsushi Mchizuki, Outcome after Cardiac Resynchronization Therapy Hidemichi Kouzu, Noriyuki Fujii, Takeru Wakabayashi, Satoshi Yuda, in Patients with Ischemic Cardiomyopathy Mamoru Hase, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Kazuaki Shimamoto, Tomoaki Nakata, Second Department of Internal Hidekazu Tanaka, Evan C. Adelstein, Prem Soman, Glen Miske, Medicine, Sapporo Medical University School of Medicine, Sapporo, Stephanie C. Haberman, Samir Saba, John Gorcsan, III, University of Japan, Hokkaido Prefecture Esashi Hospital, Esashi, Japan Pittsburgh, Pittsburgh, PA Learning Objective: evaluate Learning Objective: demonstrate that ICM patients with a high scar burden had a low response to CRT and poor long-term outcome 1205-242 Men Are More Susceptible than Women to the regardless of the presence of dyssynchrony Effects of Obesity on Cardiac Glucose Metabolism

1204-237 Utility Of Intraprocedural Equilibrium Radionuclide Chun H. Lin, Pilar Herrero, Pablo Soto, Jasdeep Sidhu, Suraj Angiogram To Evaluate Left Ventricular Function And Kurup, Al Waggoner, Deborah L. Delano, Robert J. Gropler, Linda R. Synchrony During Cardiac Resynchronization Therapy Peterson, Washington University School of Medicine, St Louis, MO Learning Objective: Describe the effect of obesity on myocardial Nitish Badhwar, Deanna L. Green, William Graham, Nancy Wyatt, glucose metabolism, potential hemodynamic effects, and gender- Teresa DeMarco, J. W. O’Connell, Elias H. Botvinick, University of related differences. California, San Francisco, San Francisco, CA Learning Objective: identify role of radionuclide imaging based 1205-243 Vagal Heart Rate Modulation Relates Inversely to synchrony assessment of left ventricle in patients undergoing Myocardial Oxidative Metabolism in Heart Failure cardiac resynchronization therapy Patients Both with and without Obstructive Sleep Apnea 1204-238 Left Ventricular Systolic and Diastolic Interdependence Demonstrated by Left Ventricular Petsy Pui-Sze So, Albert Swedani, Maria C. Ziadi, Peter E. Picton, Emptying and Filling Rates by Gated SPECT MPI Judith A. Leech, Robert A. deKemp, Jennifer M. Renaud, Ann Guo, Haissam Haddad, Lisa M. Mielniczuk, Olga Walter, Jean N. DaSilva, William Lane Duvall, Lori B. Croft, Samantha Buckley, Eric Ginsberg, Keiichiro Yoshinaga, Ian G. Burwash, Linda Garrard, John S. Floras, Tapan Godiwala, Thomas M. Klein, Eric Stern, Milena J. Henzlova, Rob S. B. Beanlands, University of Ottawa Heart Institute, Ottawa, Martin E. Goldman, Mount Sinai Medical Center, New York, NY ON, Canada, University of Toronto, Toronto, ON, Canada Learning Objective: Identify the additional benefit of emptying and Learning Objective: understand the relationship between vagal heart filling rates in evaluating cardiac function rate modulation and cardiac oxidative metabolism in heart failure patients with and without obstructive sleep apnea. A90 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1206 SPECT: NEWER APPLICATIONS 1207 RISK ASSESSMENT WITH SPECT MPI Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1

1206-245 Safety of Regadenoson as a Pharmacologic Stress 1207-251 A Stress Induced Fall in Ejection Fraction Within The Agent for Myocardial Perfusion Imaging in Stage Normal Range Does Not Adversely Effect Long and 3, 4 and 5 Chronic Kidney Disease Patients Not on Short Term Survival Hemodialysis Michael Greenberg, B. K. Shamloo, Isaac Opoku-Asare, Jeannie Karthikeyan Ananthasubramaniam, Gurunanthan Palani, Zehra Yu, Jason Morrissette, Ali Nasur, Washington VA Medical Center, Husain, Aarthee Karthikeyan, Vanji Karthikeyan, Henry Ford Hospital, Washington, DC Detroit, MI Learning Objective: Describe the prognostic signfican e of a decline Learning Objective: To demonstrate safety of Regadenoson in EF with stress remaining within the normal range pharmacologic stress perfusion imaging in chronic kidney disease patients not on hemodialysis 1207-252 Isolated Transient Ischemic Dilatation And The Risk Of Adverse Cardiac Events In A Cohort Of High Risk 1206-246 The Nuclear Cardiology Report: Problems, Individuals Undergoing Myocardial Perfusion Spect Predictors and Improvement Imaging

Peter L. Tilkemeier, Eva R. Serber, Mary Beth Farrell, The Miriam Abdul Hakeem, Sabha Bhatti, Jeffrey R. Cook, Su Min Chang, Hospital, Providence, RI, Intersocietal Commission for the University of Cincinnati College of Medicine, Cincinnati, OH Accreditation of Nuclear Medicine Laboratories, Ellicott City, MD Learning Objective: understand the prognostic value of isolated TID Learning Objective: Demonstrate the important elements in high in patients with an otherwise normal myocardial perfusion SPECT quality nuclear cardiology reporting and the associated factors imaging leading to poor quality reporting and understand methods for improvement. 1207-253 Utility of Routine Screening for Myocardial Ischemia Using Technecium-99m Single Photon Emission 1206-247 Utility of a Low Dose Technetium Stress Protocol to Computed Tomography (Tc-99m SPECT) Imaging in Minimize Radiation Exposure in Patients with Low Non-selected Post-renal Transplant Patients to Intermediate Pre-test Likelihood of Obstructive CAD Wee Tiong Yeo, Eric Hong, Arvind Sinha, Raymond Wong, National University Heart Centre, Singapore, Singapore, Singapore Mehreen Qureshi, Amsale Robi, Ketan Bhatia, Sabahat Bokhari, Columbia University, New York, NY Learning Objective: Describe the utility of SPECT imaging in screening renal transplant patients for ischemia. Learning Objective: identify a way to reduce radiation exposure for nuclear stress testing 1207-254 Does the Obesity Paradox Exist in Diabetic Patients with no Known Coronary Artery Disease? Risk 1206-248 Reduced Isotope Dose and Rapid Imaging SPECT Stratification using Stress Single Photon Emission Imaging and Diagnostic Testing Imaging and Diagnostic MPI with Excellent Image Quality Computed Tomography Myocardial Perfusion William Lane Duvall, Lori B. Croft, Tapan Godiwala, Eric Ginsberg, Imaging Titus George, Milena J. Henzlova, Mount Sinai Medical Center, New Mahjabeen Rashid, Abhijit Ghatak, Vivian Teixeira, Sanjeev U. Nair, York, NY Fawad Kazi, Farooq Iqtidar, Alan Ahlberg, Mathur Shishir, Roger Learning Objective: Describe new SPECT camera technology’s ability Mennett, Deborah Katten, Gary Heller, Donna Polk, Henry Low to significantly reduce radiation exposure while also substantially Heart Center, Hartford Hospital Nuclear Laboratories, Hartford decreasing image acquisition time. Connecticut, Hartford, CT, University of Connecticut, Farmington, CT Learning Objective: Evaluate 1206-249 Application of Appropriateness Criteria to Stress Single-Photon Emission Computed Tomography 1207-255 Prevalence and Predictors of Abnormal Myocardial Sestamibi Studies: A Comparison of the 2009 Perfusion in Patients with Type 1 Diabetes Revised Appropriateness Criteria to the 2005 Original Criteria Roxana Djaberi, Joanne D. Schuijf, Cornelis J. Roos, Marcel P. Stokkel, Petra Dibbets-Schneider, Arthur J. Scholte, Jan W. Smit, Damita J. Carryer, J. Wells Askew, David O. Hodge, Todd D. Miller, Johannes A. Romijn, Alberto M. Pereira, Ernst E. van der Wall, J. Raymond J. Gibbons, Mayo Clinic, Rochester, MN Wouter Jukema, Jeroen J. Bax, Leiden University Medical Center, Leiden, The Netherlands Learning Objective: Describe the impact of the application of the 2009 ACCF/ASNC appropriateness criteria revisions for stress Learning Objective: Describe the Prevalence of Silent Myocardial SPECT MPI studies as compared to the application of the criteria Ischemia in Type 1 Diabetes and Identify the Risk Factors published in 2005. Associated with Severe Myocardial Ischemia JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A91

1207-256 Histogram Analysis Improves Diagnostic Value of 1253-192 2-D Ultrasound Speckle Tracking Strain Imaging of 2D Longitudinal Strain In Patients with Coronary the left atrium in the Estimation of Left Ventricular Artery Disease (CAD) Filling Pressures.

Sarah Shimoni, Xavier Filtz, Oded Ayzenberg, Gera Gendelman, Fabio Mitsuru Masaki, Yong-Mei Cha, Toshinori Yuasa, Gabriella Veress, Kuznietz, Orly Edri, Nachum Smirin, Peter Lysyansky, Avraham Caspi, Kan Dong, Ying-Xue Dong, Sunil V. Mankad, Jae K. Oh, Mayo clinic, Zvi Friedman, Kaplan Medical Canter, Rehovot, Israel, GE healthcare, Rochester, MN Haifa, Israel Learning Objective: Septal and lateral left atrial strain before atrial Learning Objective: Thi study describes a new method of contraction measured by STSI (S-LA Pre-A) appears to be a useful longitudinal strain assessment that can improve detection of adjunct measure for estimating mean LA pressure at various heart coronary artery disease at rest in patients hospitalized with angina rates.

1253-193 Left Atrial Reservoir Function Predicts Atrial 1253 GENERAL ECHOCARDIOGRAPHY: ATRIAL Fibrillation Recurrence After Catheter Ablation: A FUNCTION ASSESSMENT Two-dimensional Speckle Strain Study

Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Mahek Mirza, Giuseppe Caracciolo, Uzma Khan, Komandoor Georgia World Congress Center, Hall B5 Srivathsan, Gregory Altemose, Luis Scott, Partho Sengupta, Arshad Presentation Hour: 9:30 a.m. - 10:30 a.m. Jahangir, Mayo Clinic, Scottsdale, AZ CME/CE Hours: 1 Learning Objective: Identify left atrial reservoir function as a predictor for atrial fibrillation recurrence after catheter ablation 1253-188 Left Atrial Function Assessed by Velocity Vector Imaging Is a Novel and Useful Marker to Predict the 1253-194 Predictors of Increasing Left Atrial Volume Over Five Risk for the Development of Atrial Fibrillation Years in Coronary Artery Disease Patients: Results From the Heart and Soul Study Takeshi Hirose, Ryuhei Tanaka, Michio Arakawa, Koji Ono, Ritsuko Tanaka, Tomomi Endo, Humitaka Tokoro, Reiko Matsuoka, Shintaro Kabir J. Singh, Beth Cohen, Bee Ya Na, Mary A. Whooley, Nelson Abe, Yoshiyuki Goto, Tomoko Hirose, Takashi kato, Tai Kojima, B. Schiller, San Francisco VA Medical Center, San Francisco, CA, Makoto Iwama, Shunichiro Warita, Toshiyuki Noda, Sachiro University of California San Francisco, San Francisco, CA Watanabe, Takatomo Watanabe, Masanori Kawasaki, Sinya Minatoguchi, Gifu Prefectural General Medical Center, Gifu, Japan Learning Objective: Identify factors that predict left atrial enlargement over time. Imaging and Diagnostic Testing Learning Objective: Demonstrate that reduced left atrial function assessed by velocity vector imaging is a novel and useful marker to 1253-195 Determinants of Left Atrial Volume in Healthy predict the high risk patients for the development of atrial fibrillation Individuals and Athletes

1253-189 Preoperative Left Atrial Dysfunction and Risk of Stefano Nistri, Maurizio Galderisi, Leopoldo Pagliani, Iacopo Postoperative Atrial Fibrillation (POAF) Complicating Olivotto, Antonio Santoro, Barbara Papesso, Pasquale Innelli, Franco Thoracic Surgery Cecchi, CMSR Veneto Medica, Altavilla Vicentina, Italy

Tina Raman, Nancy Roistacher, Jennifer Liu, Hao Zhang, Weiji Shi, Learning Objective: identify the determinants of left atrial volume Howard Thaler, David Amar, Memorial Sloan-Kettering Cancer Center, index in healthy subjects New York, NY Learning Objective: To understand risk factors for atrial fibrillation 1254 GENERAL ECHOCARDIOGRAPHY: PROGNOSIS after thoracic surgery AND FILLING PRESSURE BY TDI AND STRAIN IMAGING 1253-191 Differentiation of Left Atrial Volume by Time (dV/ dt) Is a Novel and Useful Echo Index to Assess Left Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Atrial Global and Phasic Function Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Takeshi Hirose, Ryuhei Tanaka, Koji Ono, Satoshi Yamajima, Yaeko Furuta, Humitaka Tokoro, Reiko Matsuoka, Shintaro Abe, Yoshiaki CME/CE Hours: 1 Goto, Tomoko Hirose, Takashi Kato, Tai Kojima, Shunichiro Warita, Makoto Iwama, Toshiyuki Noda, Sachiro Watanabe, Takatomo 1254-197 Identification of Restrictive Transmitral Flow Watanabe, Masanori Kawasaki, Sinya Minatoguchi, Gifu Prefectural Velocity Pattern by the Change of its Pattern after General Medical Center, Gifu, Japan Nitroglycerin Spray Oral Administration

Learning Objective: Evaluate the usefulness of differentiation of Hirotsugu Yamada, Kusunose Kenya, Susumu Nishio, Noriko Tomita, left atrial volume by time as a new marker of left atrial function and Keisuke Endo, Toshiyuki Niki, Kunihiko Koshiba, Koji Yamaguchi, demonstrate that it will be a novel promising method to assess left Yoshio Taketani, Takahi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, atrial function Masashi Akaike, Masataka Sata, The University of Tokushima, Tokushima, Japan, Tokushima University Hospital, Tokushima, Japan Learning Objective: distinguish pseudonormal from normal mitral inflow pattern A92 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1254-198 Noninvasive Prediction of Complications with 1255 TISSUE IMAGING: ECHOCARDIOGRAPHIC ST-Elevation Myocardial Infarction by Global ASSESSMENT OF VENTRICULAR FUNCTION Longitudinal Strain Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Woo-Shik Kim, Jong Shin Woo, Sang Jin Ha, Seok Yeon Kim, Soo Georgia World Congress Center, Hall B5 Joong Kim, Weon Kim, Myeung Kon Kim, Jong-Hoa Bae, Kwon Sam Kim, Kyung Hee University Medical Center, Seoul, South Korea Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Learning Objective: We demonstrate that left ventricular global longitudinal strain is a noninvasive and simple method that enables Resting Global and Regional Left Ventricular the prediction of patient prognosis. 1255-205 Contractility in Patients with Heart Failure and Normal Ejection Fraction - Insights from Speckle- 1254-199 Prognostic Value of Left Ventricle Function by Tissue Doppler Strain Imaging in Patients with Severe Tracking Echocardiography Sepsis or Septic Shock Gabriel W.K. Yip, Qing Zhang, Jun-Min Xie, Yu-Jia Liang, Ying-Mei Liu, Bryan P. Yan, Yat-Yin Lam, Cheuk-Man Yu, The Chinese University of Mitsuru Masaki, Juan N. Pulido, Toshinori Yuasa, Sunil V. Mankad, Hong Kong, Hong Kong, Hong Kong, West China Hospital, Sichuan Jae K. Oh, Mayo clinic, Rochester, MN University, Chengdu, Sichuan, People’s Republic of China Learning Objective: Evaluation of the left ventricular (LV) longitudinal Learning Objective: gain better mechanistic insights of contraction by tissue Doppler strain imaging may serve as useful pathophysiology of heart failure with a normal ejection fraction. tool to predict survival in patient with severe sepsis or septic shock with preser 1255-206 Strain Imaging Using Dynamic 3D Echocardiography: An In Vitro Validation Study 1254-201 Left Atrial Volume Predicts Congestive Heart Failure in Patients with Atrial Fibrillation David J. Sahn, Li Xiong, Karen Li, Shiza Ashraf, Sarah Yang, Max Carlson, Colleen Newey, Zhiwen Zhou, Muhammad Ashraf, Oregon Satoshi Tsujimoto, Yoko Miyasaka, Kinuko Dote, Hiroshi Maeba, Health & Science University, Portland, OR Fumio Yuasa, Toshiji Iwasaka, Kansai Medical University, Hirakata, Japan Learning Objective: understand speckle tracking assessment of myocardial infarct Learning Objective: Determine the clinical importance of LA volume in the prediction of CHF in AF 1255-208 Assessment of Left Ventricular Function Using Speckle Tracking Echocardiography During 1254-203 Should Normal Cutoff Values for E/e’ and BNP Differ in the Presence of Obesity? Vasopressor-Induced Increases in Afterload in a Rabbit Model Aaron Matthew From, Carolyn S.P. Lam, Sridevi R. Pitta, Prasanna V. Kumar, Kais A. Balbissi, Jeffrey D. Booker, Guy S. Reeder, Inder M. David J. Sahn, Anneka Hooft, Jonathan Ho, Wei Zhou, Jennifer Singh, Paul Sorajja, Barry A. Borlaug, Mayo Clinic, Rochester, MN Corniea, Elizabeth Sanchez, Aman Mahajan, Muhammad Ashraf, Oregon Health & Science University, Portland, OR, University of Learning Objective: Describe how E/e’ and NT-BNP cufoff values California, Los Angeles, CA for the prediction of elevated wedge pressure change in obese and non-obese patients. Learning Objective: understand alteration of cardiac mechanics with adrenergic agents

Imaging and Diagnostic Testing Imaging and Diagnostic 1254-204 Do E/E’ or E/Vp Track Changes in Left-Sided Filling Pressure in Individual Patients with Heart Failure 1255-209 Left Ventricular Transmural Mechanics in ST- with Preserved Ejection Fraction? segment Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention Paul S. Bhella, Eric L. Pacini, Anand Prasad, Jeffery L. Hastings, Benjamin D. Levine, The University of Texas-Southwestern, Dallas, Giuseppe Caracciolo, Mackram Eleid, Nisha Bhatia, David F. Fortuin, TX, Dallas, TX, The Institute of Exercise and Environmental Medicine Susan Wilansky, Scipione Carerj, Jagat Narula, Bijoy Khandheria, at Texas Health Resources, Dallas, TX Partho P. Sengupta, Mayo Clinic Arizona, Scottsdale, AZ, Aurora Health Care, Milwaukee, WI Learning Objective: Identify the limitations of echocardiographic indices to track changes in left-sided filling pressures in patients Learning Objective: To understand the incremental value to speckle with heart failure with preserved ejection fraction. tracking imaging in ST-elevation myocardial infarction

1255-210 The Sum of Systolic and Diastolic Velocity of the Mitral Annulus Can Predict the Prognosis in Acute Myocardial Infarction

Yamato Fukuda, Nobuo Fukuda, Koichi Sakabe, Satofumi Morishita, Hisanori Shinohara, Yoshiyuki Tamura, Department of Cardiology and Clinical Research, National Hospital Organization Zentsuji Hospital, Kagawa, Japan Learning Objective: Evaluate that the sum of mitral annulus velocities may be useful index to predict the prognosis in patients with acute myocardial infarction JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A93

1255-211 Impact of Loading Condition on the Two- 1256-217 Strain-rate by Tissue Strain Imaging Is Powerful dimensional Speckle Tracking-derived Left Tool to Evaluate Ischemic Diastolic Stunning Course Ventricular Dyssynchrony Index in Non-ischemic after Reperfused ST-Elevation Acute Coronary Dilated Cardiomyopathy Syndrome

Hyung-Kwan Kim, Hyo-Eun Park, Sung-A Chang, Ji-Hyun Kim, Myung- Noriaki Iwahashi, Masami Kosuge, Jun Okuda, Kengo Tsukahara, Ki Seo, Yong-Jin Kim, Goo-Yeong Cho, Dae-Won Sohn, Byung-Hee Oh, Yoshio Tahara, Kiyoshi Hibi, Toshiaki Ebina, Shinichi Sumita, Kazuaki Young-Bae Park, Seoul National University Hospital, Seoul, South Uchino, Toshiyuki Ishikawa, Satoshi Umemura, Kazuo Kimura, Korea, Seoul Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan Learning Objective: Demonstrate relationship between LV dyssynchrony and loading status Learning Objective: understnad that strain-rate by tissue strain imaging might be useful to evaluate the time course of diastolic stunning in patients with reperfused ST elavation acute coronary 1256 TISSUE IMAGING: ADVANCES IN STRAIN syndrome. IMAGING Transmural Myocardial Strain Profile is a Useful Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. 1256-218 Method to Estimate the Regional Myocardial Georgia World Congress Center, Hall B5 Stunnning Course among Patients with a Presentation Hour: 9:30 a.m. - 10:30 a.m. Reperfused ST Elevation Acute Myocardial CME/CE Hours: 1 Infarction : A Comparison with Tc-99m Sestamibi Single Photon Emission Computed Tomography 1256-214 Final Transmural Extent of Myocardial Infarction at 4-Month Cardiac Magnetic Resonance Can Be Noriaki Iwahashi, Masami Kosuge, Jun Okuda, Kengo Tsukahara, Predicted by 2-Dimensional Speckle Tracking Strain Yoshio Tahara, Kiyoshi Hibi, Toshiaki Ebina, Shinichi Sumita, Kazuaki Imaging in the Acute Phase Uchino, Toshiyuki Ishikawa, Satoshi Umemura, Kazuo Kimura, Division of Cardiology, Yokohama City University Medical Center, Mario Previtali, Michela Cottini, Sergio Leonardi, Claudia Raineri, Yokohama, Japan Annalisa Turco, Margherita Calcagnino, Guido Tavazzi, Fiorenza Fava, Learning Objective: understand that tissue strain imaging might Erica Ferrara, Luigi Oltrona Visconrti, IRCCS Pol. S.Matteo-Univ. of be useful to estimate the regional myocardial stunning course in Pavia, Pavia, Italy reperfused STEMI.

Learning Objective: Evaluate the ability of 2-dimensional strain Imaging and Diagnostic Testing imaging performed in the acute phase of myocardial infarction to 1256-220 Echo-Derived Assessment of Pulsatility Diverges predict final transmural extent of infarction assessed by cardiac From Pump-Derived Assessment, and Defines magnetic resonance Serious Adverse Events Late After Continuous Flow Left Ventricular Assist Device Implantation 1256-215 Association of Decreased Left Atrial Strain and Strain Rate with Stroke in Chronic Atrial Fibrillation Jennifer Goerbig, Guha Ashrith, Wassef Karrowni, Frances L. Johnson, Robert M. Weiss, University of Iowa, Iowa City, IA Jhih-Yuan Shih, Wei-Chuan Tsai, Yao-Yi Huang, Yen-Wen Liu, Chih- Chan Lin, Liang-Miin Tsai, Li-Jen Lin, Tainan Hospital Sin-Hua Learning Objective: understand methods of assessment of VAD flow Branch, Tainan, Taiwan,ROC, Department of Internal Medicine, kinetics, and their application. National Cheng Kung University Medical Center, Tainan, Taiwan,ROC Learning Objective: describe that in chronic AF patients, those with 1257 NEW IMAGING APPROACHES TO ASSESS decreased left atrial strain and strain rate would have higher risk of MYOCARDIAL FUNCTION stroke. Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. 1256-216 Myocardial Steatosis and Left ventricular Strain Georgia World Congress Center, Hall B5 and Strain Rate Imaging in Patients with Type 2 Presentation Hour: 9:30 a.m. - 10:30 a.m. Diabetes Mellitus CME/CE Hours: 1 Arnold C. Ng, Victoria Delgado, Matteo Bertini, See Hooi Ewe, Myocardial Late Gadolinium Enhancement Does Rutger W. van der Meer, Luuk J. Rijzewijk, Hans-Marc Siebelink, 1257-222 Johannes WA Smit, Michaela Diamant, Johannes A. Romijn, Albert Occur in the Tako-tsubo Cardiomyopathy Syndrome de Roos, Dominic Y. Leung, Hildo J. Lamb, Jeroen J. Bax, Leiden - a Cardiac Magnetic Resonance Study University Medical Center, Leiden, The Netherlands Christian R. Hamilton-Craig, Tanya Wood, Wendy E. Strugnell, Learning Objective: Describe subtle changes in left and right Richard E. Slaughter, Centre for Cardiovascular Imaging, Prince ventricular myocardial functions in type 2 diabetic patients with Charles Hospital, Brisbane, Australia, University of Queensland, myocardial steatosis on magnetic resonance imaging Brisbane, Australia Learning Objective: Appreciate that diffuse late gadolinium enhancement does occur in the TakoTsubo cardiomyopathy if CMR is performed early. A94 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1257-224 Evaluation of Right Ventricular Dysfunction in 1258-230 What Is The Underlying Plaque Morphology Of Patients with Intestinal Carcinoid Disease -Added Coronary Thrombosis? An Angioscopic And Virtual Value by Myocardial Strain Echocardiography and Histology Intravascular Ultrasound Correlative Study Tricuspid Annular Plane Systolic Excursion Elias Sanidas, Akiko Maehara, Gary S. Mintz, Toshikazu Kashiyama, Kristina H. Haugaa, Laura G. Sahakyan, D. S. Bergestuen, Helge So-Yeon Choi, Jin Bae Lee, George Dangas, Martin Leon, Jeffrey Skulstad, Espen Thiis-Evensen, Thor Edvardsen, Oslo University Moses, Gregg W. Stone, Yasunori Ueda, Columbia University Medical Hospital, Rikshospitalet, Oslo, Norway Center and the Cardiovascular Research Foundation, New York, NY, Cardiovascular Division, Osaka Police Hospital, Osaka, Japan Learning Objective: evaluate right ventricular function in patients with intestinal carcinoid tumors Learning Objective: Identify the plaque morphology of coranary thrombosis 1257-225 Serial Changes Of Left Ventricular Long And Short Axis Function In Doxorubicin-treated Murine Heart 1258-231 Inhibition Of Interleukin-1 Activity Is Related with Reduced Apoptosis and Improved Speckle Yong H. Kim, Mi-Na Kim, Sun-Won Kim, Seong-Mi Park, Woo-Hyuk Tracking Myocardial Deformation in Patients with Song, Wan-Joo Shim, Korea University Anam Hospital, Seoul, South Rheumatoid Arthritis Korea Ignatios Ikonomidis, Stavros Tzortzis, Ioannis Paraskevaidis, John Learning Objective: understand the usefulness of 2-D speckle Lekakis, Ioanna Andreadou, Maria Nikolaou, Pelagia Katsibri, tracking echocardiography in early detection of progressive left Pinelopi Dasou, Dimitrios Th Kremastinos, 2nd Cardiology ventricular failure Department, University of Athens, Attikon Hospital, Athens, Greece 1257-226 Identification of Myocardial Edema in Acutely Learning Objective: Evaluate the relation of reduced apoptosis and Reperfused Infarction by Echocardiographic improvement in myocardial deformation in rheumatoid arthritis after Deformation Parameters inhibition of Il-1 receptors

Patricia Mahia, Río Aguilar, Víctor Pineda, Bruno Garcia, Martín 1258-232 Carotid Ultrasound Identifies High Risk Subclinical Thomas, Jose Rodriguez, Arturo Evangelista, David García-Dorado, Atherosclerosis in Adults with Low Framingham Hospital Vall d´Hebron, Barcelona, Spain Risk Scores Learning Objective: Identify stunned myocardium by means of Mackram Eleid, Steven Lester, Troy Wiedenbeck, Sharad Patel, echocardiographic deformation analysis Christopher Appleton, Matthew Nelson, Julie Humphries, R. Todd Hurst, Mayo Clinic, Scottsdale, AZ 1258 TISSUE IMAGING AND VASCULAR BIOLOGY Learning Objective: Demonstrate the ability of carotid ultrasound Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. to identify high risk subclinical atherosclerosis in young individuals with low Framingham Risk Score Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1259 ADVANCES IN IMAGING AND MYOCARDIAL FUNCTION Reproducibility of Near-Infrared Spectroscopy 1258-228 Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. for the Detection of Lipid Core Coronary Plaques Georgia World Congress Center, Hall B5

Imaging and Diagnostic Testing Imaging and Diagnostic and Observed Changes after Coronary Stent Implantation Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 Bobby A. Garcia, Frances Wood, Abdul-rahman Riyad Abdel-karim, Pratik A. Mehta, Daisha Cipher, Subhash Banerjee, Emmanouil 1259-234 Apical Rotation Plays a Significant Role in Brilakis, Veteran Affairs North Texas Healthcare System, Dallas, TX, Determining Left Ventricular Diastolic Function: University of Texas Southwestern Medical Center, Dallas, TX Observation During Apical Immobilization Using Learning Objective: to evaluate the reproducibility of intracoronary StarfishTM Positioner near-infrared spectroscopy and identify changes in lipid core plaque after stenting Mariko Iwasaki, Yumi Fukuta, Kasumi Masuda, Toshihiko Asanuma, Satoshi Nakatani, Osaka University Graduate School of Medicine, Suita, Japan 1258-229 Abnormal Collagen Turnover and MMP-9 Are the Common Link between Increased Arterial Stiffness, Learning Objective: evaluate the effect of apical rotation and twist Impaired Coronary Flow Reserve and LV Untwisting on cardiac function in Untreated Patients with Essential Hypertension 1259-235 3-Dimensional Speckle Tracking Imaging for Left Ignatios Ikonomidis, John Lekakis, Stavros Tzortzis, Costas Ventricular Rotation Measurement: An In Vitro Papadopoulos, Ioannis Paraskevaidis, Helen Triantafyllidi, Paraskevi Validation Study Trivilou, Dimitrios Th Kremastinos, 2nd Cardiology Department, Attikon Hospital, University of Athens, Athens, Greece David J. Sahn, Zhiwen Zhou, Li Xiong, Muhammad Ashraf, Da-Yi Learning Objective: evaluate the association of collagen turnover Hu, Xaio-Nan Dai, Ya-Wei Xu, Berkley Cameron, Bill Kenny, Oregon with vascular and LV deformation markers in hypertensives Health & Science University, Portland, OR, Toshiba America Medical Systems, Tustin, CA Learning Objective: understand quantification of LV rotation JACC March 9, 2010 ABSTRACTS: Imaging and Diagnostic Testing A95

1259-236 Planar Maps of Left Ventricular Vorticity Fields 1260-240 Pharmacologic Single Photon Emission Computed in Human Hearts: Novel Insights with the use of Tomography (SPECT) Imaging or Pharmacologic High Resolution Echo Contrast Particle Imaging Echocardiography? A Meta Analysis of Velocimetry Pharmacologic Testing for Diagnosis of High-Risk Coronary Artery Disease. Haruhiko Abe, Giuseppe Caracciolo, Marek Belohlavek, Bijoy Khandheria, A. Jamil Tajik, Jagat Narula, Krishnaswamy Nitin Mahajan, Amit Sagar, Vipin Khetarpal, Ashok Kondur, Sinan Chandrasekaran, Partho P. Sengupta, Mayo Clinic Arizona, Sarsam, Latha Polavaram, Hema Venkalaya, Yun Wang, Joel Agar, Scottsdale, AZ, University of California, Irvine, CA Luis Afonso, Wayne State University, Detroit, MI Learning Objective: Learn the features of left ventricular blood flow Learning Objective: In the absence of a head to head comparison vortex formation in human hearts of the 2 commonly used non invasive tests, pharmacologic ECHO has a higher sensitivity, and appears to be the screening method of 1259-237 Diastolic Circumferential Strain Rate during choice for high riak CAD. Isovolumic Relaxation: A Novel Measure of Diastolic Function Obtained Using a Prototype 1260-241 Prognostic Value of the Accelerated Dobutamine Radiofrequency-based Speckle Tracking Stress Echocardiography Protocol Echocardiography System Ricardo Sanz, Jose R. Ortega, Matias Pérez-Paredes, María J. Theodore J. Kolias, Matthew O’Donnell, Nicole M. Kline, Lingling Rollán, Marta Pinedo, Roman Arnold, Jose M. Novoa, Diego Jimenez, Zhang, James D. Hamilton, University of Michigan, Ann Arbor, MI Ana C. Muñoz, Francisco Fernández-Avilés, Jose A. San Román, Institute of Heart Sciences (ICICOR), Valladolid, Spain, Hospital Dr. Learning Objective: Describe a novel measure of diastolic function Negrin, Las Palmas de Gran Canaria, Spain obtained using a prototype speckle tracking echocardiography system Learning Objective: identify patients at high risk for future MACE (cardiac death, myocardial infarction and revascularization) from all patients referred to an stress echocardiography lab for diagnostic 1259-238 Clinical and Echocardiographic Characteristics of Heart Failure Patients with Wide QRS but without and prognosticat Mechanical Dyssynchrony and their Response to Role of Stress Echocardiography in Risk Resynchronization Therapy 1260-242 Stratification and Prognosis of Patients with HIV Hidekazu Tanaka, Olusegun Oyenuga, Phillip Habib, Stephanie

Haberman, Samir Saba, John Gorcsan, III, University of Pittsburgh, omar enrique wever pinzon, Jorge Silva Enciso, Emad Aziz, Jorge Imaging and Diagnostic Testing Pittsburgh, PA Romero, Deborah Cantales, Farooq A. Chaudhry, St. Luke’s Roosevelt Hospital Center, New York, NY Learning Objective: evaluate clinical and echocardiographic characteristics of HF patients with wide QRS but without mechanical Learning Objective: Evaluate the prognostic value of stress dyssynchrony and their response to CRT echocardiography in patients with HIV.

1260-243 Framingham Risk Score Should Not Be Used 1260 RISK ASSESSMENT AND STRESS to Predict Results of Stress Echocardiogram in ECHOCARDIOGRAPHY Patients with Intermediate or Higher Risk of CAD Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Michael Shea, Chandra Ojha, Gabriel Fischer, Nitendra Agarwal, Georgia World Congress Center, Hall B5 Steven A. Fein, Mikhail Torosoff, Albany Medical College, Albany, NY Presentation Hour: 9:30 a.m. - 10:30 a.m. Learning Objective: describe the utility of risk factor assessment in CME/CE Hours: 1 predicting the likelihood of an abnormal stress echocardiogram.

Application of the Appropriateness Criteria to Stress 1260-239 1261 ARTERIAL BIOLOGY AND STRESS Echocardiographic Studies in an Academic Center ECHOCARDIOGRAPHY Constantina Aggeli, Konstantinos Lampropoulos, Dimitra Koveou, John Felekos, Christina Kazazaki, Georgios Roussakis, Maria Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Salourou, Stavroula Lagoudakou, Christos Pitsavos, Christodoulos Georgia World Congress Center, Hall B5 Stefanadis, 1st Department of Cardiology, University of Athens Presentation Hour: 9:30 a.m. - 10:30 a.m. Medical School, Hippokration Hospital, Athens, Greece CME/CE Hours: 1 Learning Objective: This retrospective study demonstrates the need for the application of the appropriateness criteria in order to 1261-245 Does E/E’ Predict Left Ventricular Filling Pressures achieve quality improvement in the clinical use of this test During Dobutamine Stress Echocardiography?

Albert K. Chan, Marc L. Del Rosario, Youngju Pak, Kul Aggarwal, Kevin C. Dellsperger, Anand Chockalingham, University of Missouri- Columbia School of Medicine, Columbia, MO, Harry S Truman Memorial Veterans Hospital, Columbia, MO Learning Objective: Demonstrate the hemodynamic effects of dobutamine on E/E’ and left ventricular filling pressures A96 ABSTRACTS: Imaging and Diagnostic Testing JACC March 9, 2010

1261-246 Deceleration Time of the Left Ventricular Outflow 1262 STRESS ECHOCARDIOGRAPHY: NOVEL Tract Flow Velocity : A Useful Doppler Parameter for MEASURES AND SPECIAL POPULATIONS Dynamic Arterial Stiffness During Exercise Stress Echocardiography Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Chi Young Shim, Sungha Park, Donghoon Choi, Woo-In Yang, In- Jeong Cho, Sung-Ai Kim, Sun-Ha Moon, Jin-Mi Kim, Eui-Young Choi, Presentation Hour: 9:30 a.m. - 10:30 a.m. Namsik Chung, Jong-Won Ha, Yonsei Cardiovascular Center, Yonsei CME/CE Hours: 1 University College of Medicine, Seoul, South Korea Euglycemic Hyperinsulinemia Improves LV Learning Objective: demonstrate that a Doppler parameter of 1262-251 Performance More in Insulin Resistant Subjects left ventricular outflow tract flow is well correlated with central hemodynamics and arterial stiffness not only at rest but also at During Stress Echocardiography peak exercise. Patrick M. Heck, Stephen P. Hoole, Sadia N. Khan, Phillip A. Read, David P. Dutka, Department of Cardiovascular Medicine, Universtiy of 1261-247 Systolic Stress versus Diastolic Stress Cambridge, Cambridge, United Kingdom Echocardiography for Functional Imaging and Learning Objective: indentify that altering myocardial metabolism in Correlation with Fractional Flow Reserve in Patients subjects with insulin resistance can improve LV performance during with Stable Angina stress echo Motoyoshi Maenaka, Kansai Electric Power Hospital, Osaka, Japan, Koto Memorial Hospital, Higashioumi, Japan 1262-252 Euglycemic Hyperinsulinemia but not Hyperglycemic Hyperinsulinemia Improves LV Function During Learning Objective: Fractional flow reserve <0.83 could be optimal Stress Echo index for detection of the reversible myocardial ischemia by using diastolic stress echocardiography. Patrick M. Heck, Stephen P. Hoole, Sadia N. Khan, Phillip A. Read, David P. Dutka, Department of Cardiovascular Medicine, University of 1261-248 The Value of Systemic Endothelial Dysfunction Cambridge, Cambridge, United Kingdom and Increased Arterial Stiffness for Identifying Learning Objective: evaluate the effects of byperinsulinemia and Wall Motion Abnormalities During Stress acute hyperglycemia on LV function during stress echo Echocardiography Testing in Hypertensive Men with Vascular Erectile Dysfunction 1262-253 Feasibility of Real-Time 3D Stress Contrast Nikolaos Ioakeimidis, Charalambos Vlachopoulos, Constadina Echocardiography and Agreement with 2D Stress Aggeli, Dimitrios Terentes-Printzios, Athanasios Aggelis, George Contrast Echocardiography Roussakis, Konstantinos Rokkas, Konstantinos Aznaouridis, Alexios Constantina Aggeli, John Felekos, Konstantinos Lampropoulos, Samentzas, Christodoulos Stefanadis, Cardiovascular Diseases and Georgios Roussakis, Christina Kazazaki, Stavroula Lagoudakou, Sexual Health Unit, 1st Department of Cardiology, Athens Medical Emmanouil Poulidakis, Christos Pitsavos, Christodoulos Stefanadis, School, Athens, Greece 1st Department of Cardiology, University of Athens Medical School, Learning Objective: identify Hippokration Hospital, Athens, Greece Learning Objective: Contrast enhanced 3D dobutamine stress 1261-249 Inotropic Contractile Reserve can Risk Stratify and echocardiography is a feasible technique for both wall motion and Prognosticate Patients With HIV Cardiomyopathy: a perfusion evaluation

Imaging and Diagnostic Testing Imaging and Diagnostic Dobutamine Stress Echo Study

omar enrique wever pinzon, Jorge Silva Enciso, Jorge Romero, Emad 1262-254 Isovolumic but not Protodiastolic Left Ventricular Aziz, Daniel Pudpud, Farooq A. Chaudhry, St. Luke’s Roosevelt Untwisting Determines Diastolic Response to Hospital Center, New York, NY Dobutamine Stress Echocardiography Learning Objective: Evaluate the value of Inotropic Contractile Willis Lam, Thomas Marwick, University of Queensland, Brisbane, Reserve during DSE, in the risk stratification and prognosis of Australia patients with HIV cardiomyopathy Learning Objective: identify the association between LV torsion and filling pressure response during dobutamine stress echocardiography

1262-255 Global Longitudinal Strain Measured from Rest Echocardiography Images Has Comparable Diagnostic Accuracy as Stress Induced Wall Motion Score Index in Detecting Significant Coronary Artery Disease

Kofo O. Ogunyankin, Jyothy J. Puthumana, Shelley L. Sarson, Northwestern University, Feinberg School of Medicine. Division of Cardiology, Chicago, IL Learning Objective: Appraise the utility of global longitudinal strain in identifying the presence of coronary artery disease JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A97

ORAL CONTRIBUTIONS

912 NOVEL BIOMARKERS AND NEW APPLICATIONS 3:00 Multimarker Risk Model Containing Troponin, OF EXISTING TOOLS WITH PRACTICAL Interleukin-10, Myeloperoxidase and Placental Growth Factor Predicts Long-Term Cardiovascular IMPLICATIONS Risk after Non-ST-Segment Elevation Acute Monday, March 15, 2010, 2:00 p.m. - 3:30 p.m. Coronary Syndrome Georgia World Congress Center, Room B404 Rohit M. Oemrawsingh, Timo Lenderink, K. Martijn Akkerhuis, CME/CE Hours: 1.5 Christopher Heeschen, Stephan Baldus, Stephan Fichtlscherer, Christian W. Hamm, Maarten L. Simoons, Eric Boersma, 2:00 Diminished Paroxonase-1 Activity, A Marker of Thoraxcenter ErasmusMC, Rotterdam, The Netherlands, Dysfunctional High-Density Lipoprotein Cholesterol, Interuniversity Cardiology Institute Netherlands, Utrecht, The Reclassifies Stable Cardiac Patients at Higher Risk Netherlands for Developing Major Adverse Cardiac Events Learning Objective: evaluate the additional value of testing multiple Wai Hong Wilson Tang, Yuping Wu, Stephen J. Nicholls, Stanley L. biomarkers for long-term post-ACS risk prediction. Hazen, Cleveland Clinic, Cleveland, OH Learning Objective: To describe the independent prognostic value of 914 ACUTE MYOCARDIAL INFARCTION: COMPLETE serum arylesterase activity level in reclassifying patients at higher REVASCULARIZATION: CAN WE? SHOULD WE? IN risk of major adverse cardiac events WHOM?

2:15 Insulin-Like Growth Factor Binding Protein (IGFBP) Monday, March 15, 2010, 4:30 p.m. - 6:00 p.m. 2: A Novel Metabolic Biomarker Strongly Predictive Georgia World Congress Center, Room B404 of Future Cardiovascular Events CME/CE Hours: 1.5 Svati Hasmukh Shah, Jie-Lena Sun, Karen Pieper, Carol Haynes, Michael Muehlbauer, James R. Bain, Elizabeth R. Hauser, William E. 4:30 Complete versus Culprit Only Revascularization Is Kraus, Christopher B. Newgard, Christopher B. Granger, Robert M. Not Beneficial in Acute ST Elevation Myocardial Califf, L. Kristin Newby, Duke University, Durham, NC Infarction: A Meta-Analysis Learning Objective: Describe a novel biomarker for incident Ankur Sethi, Amol Bahekar, Rohit Bhuriya, Sarabjeet Singh, Aziz cardiovascular events. Ahmed, Sandeep Khosla, Rosalind Franklin University,Chicago Medical School, North Chicago, IL 2:30 New Universal Definition of Myocardial Infarction for Learning Objective: Evaluate current evidence demonstrating Risk Stratification and Revascularization Decision no benefit of complete revascularization over culprit only Making: Is it Enough? revascularization in ST elevation Myocardial infarction. Rita Calé, Jorge Ferreira, Carlos Aguiar, Nuno Santos, Pedro Carmo, João Figueira, Luis Raposo, Pedro Gonçalves, José A. Silva, 4:45 Is Multi-Vessel Primary PCI Advisable? Differences Cardiology Department, Hospital Santa Cruz, C.H.L.O., Lisbon, in Clinical Outcomes Among Medicare Beneficiaries Portugal, Clinical Laboratory Department, Hospital Santa Cruz, Undergoing Single versus Multi-Vessel PCI During a Myocardial Ischemia

C.H.L.O., Lisbon, Portugal Primary ST-Segment Elevated Myocardial Infarction and Infarction Hospitalization in Fiscal Year 2007 Learning Objective: Measurement of cardiac troponins is an important tool for diagnosis, risk assessment and therapeutic Aaron D. Kugelmass, Phillip P. Brown, Matthew R. Reynolds, Steven choices in patients with NSTE-ACS. Nevertheless, it should be D. Culler, April W. Simon, David J. Cohen, Baystate Medical Center, included in a global evaluation. Springfield, MA, Cardiac Data Solutions, Inc, Atlanta, GA

High Sensitivity Troponin Assays Predict Major Learning Objective: identify the increased risk of multivessel PCI for 2:45 STEMI patients Adverse Events at 2 Years and at Levels Below the 99th Percentile 5:00 Culprit and Non-Culprit PCI Compared to Culprit only Sally Aldous, Christopher Florkowski, Peter George, Martin Than, Ian PCI in Multi-Vessel Coronary Artery Disease Patients Crozier, Christchurch Hospital, Christchurch, New Zealand with Acute ST Elevation Myocardial Infarction Learning Objective: evaluate different troponin assays including high Treated by Primary Percutaneous Coronary sensitivity troponins for use in diagnosing myocardial infarction and Intervention: A Systematic Review prediction of long term adverse events Naji Alhulaimi, William Midodzi, Robert C. Welsh, UNIVERSITY OF ALBERTA, EDMONTON, AB, Canada Learning Objective: Understand available evidence regarding primary PCI in patients with multivessel CAD A98 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

5:15 Clinical and Angiographic Outcomes in Patients 11:00 Impact of Pretreatment Ischemia on Therapeutic with ST-Segment Elevation Myocardial Infarction Risk Reduction and Long-Term Prognosis in Undergoing Single Versus Multiple Vessel Patients with Stable Angina: Results from COURAGE Percutaneous Coronary Intervention Trial

Mohamed Rahman, Tonga Nfor, Suhail Allaqaband, Anjan Gupta, Leslee J. Shaw, Daniel S. Berman, David J. Maron, Rory Tanvir Bajwa, Aurora Cardiovasc Svcs, Aurora Sinai/St. Luke’s Med Hachamovitch, Pamela M. Hartigan, James K. Min, Steven P. Sedlis, Ctrs, Univ Wisconsin Sch Med & Public Health-MCC, Milwaukee, Marcin Dada, G. B. John Mancini, Robert A. O’Rourke, John A. WI, Center for Urban Population Health, University of Wisconsin- Spertus, Bernard R. Chaitman, Eric R. Bates, Koon K. Teo, William Milwaukee, Milwaukee, WI E. Boden, William S. Weintraub, Emory University, Atlanta, GA, Cedars-Sinai Medical Center, Los Angeles, CA Learning Objective: understand that multivessel intervention in acute STEMI in the setting of multivessel disease is as safe and Learning Objective: To understand the role of pre-treatment effective as single-vessel PCI during STEMI. ischemia on therapeutic outcomes.

5:30 Mortality And Morbidity Reduction By Primary 11:15 Resistance to Clopidogrel Assessed by VASP Percutaneous Coronary Intervention Is Consistent Phosphorylation Is a Negative Prognostic Factor Across Spectrum Of Age in Patients Undergoing Elective PCI for Stable Coronary Artery Disease: Analysis from Laboratory Sanneke P. De Boer, Cindy W. Westerhout, John Simes, Cindy L. Substudy of Prague 8 Trial Grines, Chris B. Granger, Felix Zijlstra, Eric Boersma, ErasmusMC, Rotterdam, The Netherlands Robert Petr, Zuzana Motovska, Iuri Marinov, Danuse Bilkova, Petr Learning Objective: We aimed to obtain a valid estimate of the Widimsky, Cardiocenter, 3rd faculty of medicine Charles University clinical effects of PPCI in relation to age Prague, University Hospital Kral. Vinohrady, Prague, Czech Republic, The Institute of Hematology and Blood Transfusion, Prague, Czech Republic 919 FACTORS ASSOCIATED WITH OUTCOME IN Learning Objective: identify ACUTE AND CHRONIC ISCHEMIA Tuesday, March 16, 2010, 10:30 a.m. - 12:00 p.m. 11:30 Long-Term Follow-Up to Evaluate the Safety of the Neovasc Reducer A Device-Based Therapy for Georgia World Congress Center, Room B403 Chronic Refractory Angina CME/CE Hours: 1.5 Shmuel Banai, Marc Schwartz, Horst Sievert, Ashok Seth, Gad Keren, Keyur H. Parikh, The Tel Aviv Medical Center, Tel Aviv, Israel 10:30 In Women with Symptoms of Cardiac Ischemia, Nonobstructive Coronary Arteries and Microvascular Learning Objective: Identify new therapeutic option for patients with Dysfunction, ACE Inhibition Is Associated with refractory angina who are not candidates for revascularization Improved Microvascular Function: A Double-Blind Randomized Ancillary Study from the NHLBI 924 CORONARY ARTERY BYPASS SURGERY: Women’s Ischemia Syndrome Evaluation (WISE) CONTEMPORARY ISSUES IN GRAFT SURVIVAL Daniel F. Pauly, B. Delia Johnson, R. David Anderson, Eileen M. AND PATIENT OUTCOMES Handberg, Karen M. Smith, Rhonda M. Cooper-DeHoff, Keith E. Muller, George Sopko, Barry M. Sharaf, Sheryl F. Kelsey, C. Tuesday, March 16, 2010, 2:00 p.m. - 3:30 p.m. Noel Bairey Merz, Carl J. Pepine, University of Florida College of Georgia World Congress Center, Room B404 Medicine, Division of Cardiovascular Medicine, Gainesville, FL CME/CE Hours: 1.5 Learning Objective: Evaluate the usefulness of angiotensin-

and Infarction converting enzyme inhibitors in women with microvascular 2:00 Coronary Artery Bypass Grafting with and without

Myocardial Ischemia dyfunction with signs and symptoms of ischemia who lack Concomitant Epicardial Cardiac Resynchronization obstructive coronary artery disease. Therapy in Patients with Ischemic Heart Failure: Long-Term Results 10:45 Relationship of Heart Rate and Cardiovascular Events in Patients after Acute Coronary Syndromes: Evgeny Pokushalov, Alexander Romanov, Darya Prohorova, Alexander An Analysis from the PROVE-IT TIMI 22 Trial Cherniavskiy, State Research Institute of Circulation Pathology, Novosibirsk, Russian Federation Sripal Bangalore, Jie Qin, Sabina Murphy, Christopher P. Cannon, Learning Objective: We revealed that epicardial implantation of the Brigham and Women’s Hospital, Boston, MA, TIMI Study Group, ˁRT system concomitantly with CABG improves clinical status, LV Boston, MA systolic function, decreases LV dyssynchrony signs Learning Objective: Evaluate the role of heart rate in the prognosis of patients post acute coronary syndromes 2:15 A Randomized Trial Radial Artery Versus Saphenous Vein Grafts in Coronary Artery Bypass Surgery: VA Cooperative Study

Steven Goldman, Gulshan Sethi, William Holman, Hoang Thai, Yvette Rodriguez, Kelvin Lee, CSP 474 Study Group, Southern Arizona VA Medical Center, Tucson, AZ Learning Objective: Data on comparative conduit patency with CABG JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A99

2:30 Vein Graft Failure Following Coronary Artery Bypass Surgery: Does it Matter?

Renato Lopes, John H. Alexander, Rajendra H. Mehta, Gail E. Hafley, Michael J. Mack, Keith B. Allen, Eric D. Peterson, Robert A. Harrington, C. Michael Gibson, Robert M. Califf, Nicholas T. Kouchoukos, T. Bruce Ferguson, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC Learning Objective: Evaluate the relationship between vein graft failure and long-term clinical outcomes in patients undergoing coronary artery bypass surgery

2:45 Combined Clopidogrel and Aspirin Treatment up to Surgery Increases the Risk of Postoperative Myocardial Infarction, Bleeding and Reoperation in Patients Undergoing Coronary Artery Bypass Grafting

Antonio Miceli, Paolo M. de Siena, Brenno Fiorani, Francesco Romeo, Gianni D. Angelini, Massimo Caputo, Bristol Heart Institute, Bristol, United Kingdom Learning Objective: evaluate the risk associated with clopidogrel in combination with aspirin in patients undergoing CABG

3:00 Modern Era Coronary Artery Bypass Graft Patency: Angiographic and Functional Outcomes in the Cascade Multicenter Randomized Controlled Trial

Alexander Kulik, Pierre Voisine, Patrick Mathieu, Roy G. Masters, Thierry G. Mesana, Michel Le May, Marc Ruel, University of Ottawa Heart Institute, Ottawa, ON, Canada, Hopital Laval, Quebec City, QC, Canada Learning Objective: Describe modern era CABG outcomes Myocardial Ischemia and Infarction A100 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

POSTER CONTRIBUTIONS

1043 ACUTE MYOCARDIAL INFARCTION--CELL BASED 1043-261 Effects Of Low Versus Moderate-dose Atorvastatin THERAPY AND CELLULAR MANIPULATIONS In 8-month Follow-up Coronary Flow Reserve And Stem Cell Mobilizations In Patients With Acute Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Myocardial Infarction Georgia World Congress Center, Hall B5 Jae Hyoung Park, Soon Jun Hong, Seung Cheol Choi, Je Sang Kim, Presentation Hour: 9:30 a.m. - 10:30 a.m. Chul-Min Ahn, Do-Sun Lim, Korea University Anam Hospital, Seoul, CME/CE Hours: 1 South Korea

Increase in Endothelial Progenitor Cells after Acute Learning Objective: learn about stem cell mobilization according to 1043-256 the statin therapy in patients with acute myocardial infarction Myocardial Infarction May Reduce Late Luminal Loss in the Stent Deployed in Infarc Related Intracoronary Stem Cell Therapy After Myocardial Coronary Artery 1043-262 Infarction - Twelve Months Follow-up Of A Motoo Date, Hiroshi Ito, Katsuomi Iwakura, Atsunori Okamura, Randomized, Rigorous Double-blind, Placebo Yasushi Koyama, Yoshiharu Higuchi, Koichi Inoue, Ryusuke Kimura, Controlled Trial Hiroyuki Nagai, Kenshi Fujii, Cardiovascular Center,Sakurabashi- Watanabe Hospital, Osaka, Japan Jochen Wöhrle, Nico Merkle, Volker Mailänder, Thorsten Nusser, Peter Schauwecker, Fabian von Scheidt, Klaus Schwarz, Martin Learning Objective: learn the effect of CD34 positive cells on Bommer, Markus Wiesneth, Hubert Schrezenmeier, Vinzenz restenosis in the bare-metal stent implanted in coronary artery. Hombach, Clinic of Internal Medicine II, University of Ulm, Ulm, Germany, Institute of Transfusion Medicine and Institute of Clinical 1043-257 First-in-Man Experience of Adipose-Derived Stem Transfusion Medicine and Immunogenetics, Ulm, Germany Cell Transplantation in the Treatment of Patients Learning Objective: interpret results of bone marrow cell therapy in with an Acute ST-Elevation Myocardial Infarction patients with acute myocardial infarction in the setting of a rigorous (APOLLO Trial) randomized placebo-controlled trial H. J. Duckers, Sr., Jaco Houtgraaf, RobertJan van Geuns, Francisco J. Fernandez-Aviles, Patrick W. Serruys, Thoraxcenter Rotterdam, 1043-263 The Calcitonin Gene-Related Peptide Receptor Erasmus University Medical Center Rotterdam, Rotterdam, The Antagonist Telcagepant Does Not Reduce Exercise Netherlands, Hospital General Universitario Gregorio Marañón, Tolerance in Patients with Exercise Induced Madrid, Spain Myocardial Ischemia

Learning Objective: Identify alternative treatment of patients Bernard R. Chaitman, Andrew P. Ho, Martin O. Behm, Janice F. admitted with an acute myocardial infarction Rowe, John S. Palcza, Tine Laethem, Ingeborg Heirman, Deborah L. Panebianco, Valentin S. Moiseev, Sergey Y. Martsevich, Almena 1043-259 N-terminal Pro-B-Type Natriuretic Peptide Levels L. Free, Neville Bittar, Steven G. Chrysant, Tony W. Ho, Jeffrey A. Is Associated with Endothelial Progenitor Cell Chodakewitz, M. Gail Murphy, Rebecca L. Blanchard, Saint Louis Mobilization after Percutaneous Coronary University School of Medicine, Division of Cardiology, St. Louis, MO, Intervention in Patients with Acute Myocardial Merck & Co., Inc., North Wales, PA Infarction Learning Objective: Evaluate Telcagepant (MK-0974), a novel investigational calcitonin gene-related peptide CGRP receptor Youngkeun Ahn, Seo Na Hong, Keun Ho Park, Nam Sik Yoon, Do Sun antagonist, being developed to treat migraines on exercise induced Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jeong Gwan myocardial ischemia threshold. Cho, Jong Chun Park, Jung Chaee Kang, Department of Cardiology, Chonnam National University Hospital, Gwangju, South Korea,

and Infarction Seonam University Hospital, Namwon, South Korea 1044 ACUTE MYOCARDIAL INFARCTION--OUTCOMES

Myocardial Ischemia Learning Objective: to evaluate the relation between the EPC Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. mobilization and improvement of left ventricular function and predictor for EPC mobilization Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. 1043-260 Red Ginseng Extracts Improved Coronary Flow CME/CE Hours: 1 Reserve and Increased Absolute Numbers of Various Circulating Angiogenic Cells in Patients with 1044-265 Predictors of In-hospital Mortality in a ST-elevation myocardial infarction Contemporary Acute Myocardial Infarction Population: Results from the ACTION Registry-Get Doosup Shin, Soon Jun Hong, Jae Hyoung Choi, Ju Hyeon Kim, with the Guidelines Program Je Sang Kim, Jae Hyoung Park, Chul-Min Ahn, Do-Sun Lim, Korea University Anam Hospital, Seoul, South Korea Matthew T. Roe, Anita Y. Chen, Elizabeth DeLong, Tracy Y. Wang, John S. Rumsfeld, Christopher P. Cannon, Gregg C. Fonarow, Eric D. Learning Objective: to learn about effect of Red Ginseng to coronary Peterson, Duke Clinical Research Institute, Durham, NC flow reserve in patients with ST-elevation myocardial infarction Learning Objective: use a risk model developed from the ACTION Registry-GWTG program to predict in-hospital mortality among patients with acute myocardial infarction (both NSTEMI and STEMI). JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A101

1044-266 The Influence of Previous Myocardial Infarction 1044-271 Major Bleeding Complications in Patients With on 12-month Clinical Outcomes in Patients with STEMI Account for a Doubling in Hospital Mortality Recurrent ST-segment Elevation Acute Myocardial in Clinical Practice: Lessons From the Euro Heart Infarction Undergoing Primary Percutaneous Survey ACS Registry Coronary Intervention Anselm K. Gitt, Frank Towae, Ralf Zahn, Huo Katus, Marek Seung Woon Rha, Lin Wang, Ji Young Park, Kanhaiya L. Poddar, Gierlotka, Wojtek Wojakowski, Michal Tendera, Francois Schiele, Sureshkumar Ramasamy, Byoung Geol Choi, Ji Bak Kim, Seung Jean-Pierre Bassand, Euro Heart Survey ACS Registry, Institut Yong Shin, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju f. Herzinfarktforschung Ludwigshafen, University of Heidelberg, Kim, Eung Ju Kim, Hong Seog Seo, Dong Joo Oh, Myung Ho Jeong, Ludwigshafen, Germany, Herzzentrum Ludwigshafen, Ludwigshafen, Cardiovascular Center, Korean University Guro Hospital, Seoul, Germany South Korea, Cardiovascular Center, Chon Nam National University Learning Objective: identify patients with high risk for bleeding Hospital, Gwangju, South Korea Learning Objective: The Influence of Previous Myocardial Infarction on 1044-272 Gender Outcomes in a Community Level 1 Program 12-month Clinical Outcomes in Patients with Recurrent ST-segment of Catheter-Based Rapid Reperfusion for Acute ST- Elevation Acute Myocardial Infarction Undergoing Primary PCI Segment Elevation Myocardial Infarction

1044-267 Trends in the Management and Outcomes of Elizabeth Grey, Catherine A. Pastorius, Timothy D. Henry, Sue Duval, Cardiogenic Shock Complicating Acute Myocardial Denise C. Windenburg, Robert G. Hauser, Minneapolis Heart Institute Infarction Foundation at Abbott Northwestern Hospital, Minneapolis, MN Learning Objective: Understand gender differences in STEMI Sen Matsumoto, Yasuhiko Sakata, Masahiko Shimizu, Shinichirou Suna, Masaya Usami, Tatsuya Sasaki, Masami Nishino, Issei Komuro, Hiroshi Sato, Osaka University Graduate School of 1045 ACUTE MYOCARDIAL INFARCTION--NOVEL Medicine, Suita, Japan PHARMACOLOGIC APPROACHES Learning Objective: Clinical outcomes in patients with cardiogenic shock complicating AMI became getting better, along with progress Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. of reperfusion therapy. Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. 1044-268 Predicting Major Adverse Cardiac Events and Infarct CME/CE Hours: 1 Size using ST-Segment Resolution as a Continuous Rather than a Dichotomous Variable in Patients 1045-273 Use of Ivabradine in the Management of Acute Achieving Thrombolysis in Myocardial Infarction Anterior Wall Myocardial Infarction Complicated by Flow Grade III after Primary Percutaneous Coronary Left ventricular Failure Intervention for ST-Segment Elevation Myocardial Rajagopal J, Srinivas Arun, Keshavamurthy B. Chakrabhavi, Infarction Guruprasad HP, Jayakumar P, Arjun Adnaik, Vikram Hospital and Wichert J. Kuijt, Andrzej S. Kosinski, Niels J. Verouden, Joost D. Heart Care, Mysore, Haeck, Matthew T. Roe, Cindy L. Green, Karel T. Koch, Ricardo Learning Objective: Evaluate the newer agent ivabradine in the Baeza, Dan Tzivoni, Robbert J. De Winter, Mitchell W. Krucoff, Duke management of acute heart failure Myocardial Ischemia

Clinical Research Institute, Durham, NC and Infarction Learning Objective: Demonstrate that STR is more predictive of clinical 1045-274 Bivalirudin Therapy is Associated with Improved outcome and infarct size when expressed as a continuous variable in Clinical and Economic Outcomes in STEMI Patients all patients and those achieving TIMI-3 flow after primary PCI Undergoing PCI: Results from an Observational Database 1044-269 Female Gender in STEMI: Influence on Mortality and Reperfusion: Results from the Belgian STEMI Duane S. Pinto, M.P.H., Augustina Ogbonnaya, Sharon-Lise Normand, Registry Beth Israel Deaconess Medical Center, Boston, MA, Harvard Medical School, Boston, MA Sofie Agnes Gevaert, Antoine De Meester, Patrick Evrard, Marc Learning Objective: Understand the advantages and disadvantages Renard, Christophe Beauloye, Patrick Coussement, Herbert De of using a large database for evaluation of costs and outcomes in Raedt, Marc Claeys, Ghent University Hospital, Gent, Belgium, STEMI. BIWAC, Belgium Learning Objective: to evaluate sex differences in treatment and 1045-276 Time Course Of Urinary Isoprostane Excretion And outcome of ST segment elevation myocardial infarction Effect Of Atrial Natriuretic Peptide Administration On Oxidative Stress During Acute Phase Of Myocardial Infarction

Ryosai Nakamura, Hideki Nagoshi, Tetsunori Ishikawa, Haruhito Kumagae, Kouji Kobayashi, Takahiro Sumi, Hironao Iwakiri, Shohei Koyama, Takuroh Imamura, Kazuo Kitamura, Miyakonojo Resional Medical Center, Miyakonojo, Japan Learning Objective: identify A102 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1045-277 Effect of Apixaban on Coagulation Acitvity 1046-283 Risk-Treatment-Paradox In STEMI With Impaired Biomarkers Following Acute Coronary Syndrome: Renal Function in Clinical Practice in Europe: Lessons from the APPRAISE Trial Lessons From the Euro Heart Survey ACS Registry

Richard C. Becker, John H. Alexander, YuChen Barrett, Honqqui Anselm K. Gitt, Frank Towae, Ralf Zahn, Hugo Katus, Alexander Yang, Jessie Wang, Lars Wallentin, Robert A. Harrington, Duke Pakhomenko, Francois Schiele, Jean-Pierre Bassand, Euro Heart University Medical Center, Durham, NC Survey ACS Registry, Institut f. Herzinfarktforschung Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany, Herzzentrum Learning Objective: Demonstrate the affect of Factor Xa inhibition Ludwigshafen, Ludwigshafen, Germany on biomarkers of coagulation activity Learning Objective: identify patients with STEMI at high risk 1045-278 Interleukin-1 Blockade Ameliorates Left Ventricular Remodeling Following St-segment Elevation Acute 1046-284 Impact of Chronic Kidney Disease and Anemia on Myocardial Infarction - The VCU-ART Pilot Study 5-Year Mortality after Acute Myocardial Infarction

Antonio Abbate, Michael C. Kontos, John Grizzard, Giuseppe GL Kazuoki Dai, Masaharu Ishihara, Ichiro Inoue, Takuji Kawagoe, Yuji Biondi-Zoccai, Benjamin W. Van Tassell, Roshanak Robati, Ross Shimatani, Satoshi Kurisu, Yasuharu Nakama, Eisuke Kagawa, Arena, Charlotte Roberts, Amit Varma, Christopher Gelwix, Fadi N. Takayuki Otani, Hiroki Ikenaga, Yoshimasa Morimoto, Kentaro Ejiri, Salloum, Andrea Hastillo, Charles A. Dinarello, George W. Vetrovec, Nozomu Oda, Hiroshima City Hospital, Hiroshima, Japan, Hiroshima, Virginia Commonwealth University, Pauley Heart Center, Richmond, VA Japan Learning Objective: To describe the beneficial effects of IL-1 Learning Objective: evaluate prognostic utility of combination blockade in STEMI of chronic kidney disease and anemia in patients with acute myocardial infarction. 1045-279 Cardiovascular Effects of Tumour Necrosis Factor Alpha Antagonism in Patients with Acute 1046-285 Safety and Efficacy of Adjusted-Dose Eptifibatide Myocardial Infarction in Patients with Acute Coronary Syndromes and Reduced Renal Function Gareth J. Padfield, Jehangir N. Din, Nicholas L. Mills, Elena Koushiappi, Simon D. Robinson, Andrew J. Lucking, Nicholas L. Chiara Melloni, Stefan K. James, Jennifer A. White, Robert P. Cruden, Stan Chia, Scott A. Harding, David E. Newby, University Of Giugliano, Robert A. Harrington, Kurt Huber, Paul W. Armstrong, Edinburgh, Edinburgh, United Kingdom Robert M. Califf, Frans Van de Werf, Gilles Montalescot, L. Kristin Newby, Duke Clinical Research Institute, Durham, NC Learning Objective: TNF-alpha antagonism in acute coronary syndromes does not improve vasomotor or fibrinolytic function and Learning Objective: describe the safety and efficacy of eptifibatide may be harmful dose adjustment in patients with reduced renal function.

1045-280 Feasibility of Continuous Intravenous Administration 1046-286 Prevention of Contrast-Induced Nephropathy of Landiolol for Acute Myocardial Infarction :first with Bolus Injection of Sodium Bicarbonate in clinical experience and its safe directions for use Patients with Chronic Kidney Disease Undergoing an Emergent Coronary Procedure: A Prospective haruhiko higuchi, Hitachi General Hospital,Department of Randomized Controlled Trial Cardiology, Hitachi, Japan Hiromichi Ueda, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Learning Objective: demonstrate that intravenous ultra short- Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Taku yasui, Takeshi acting beta-blockade reduce cardiac damage in patients with acute Okada, Masato Kawasaki, Yuki Kuramoto, Masatake Fukunami, myocardial infarction. Osaka General Medical Center, Osaka, Japan Learning Objective: demonstrate the effect of sodium bicarbonate 1046 ACUTE MYOCARDIAL INFARCTION--OPTIMIZING and Infarction bolus injection. THERAPY IN HIGH RISK SUBSETS: RENAL Myocardial Ischemia FAILURE 1046-288 Relationship Between Renal Function, Anticoagulation Levels and Clinical Outcome in Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. ST-elevation Myocardial Infarction Patients Treated Georgia World Congress Center, Hall B5 with Primary Percutaneous Coronary Intervention Presentation Hour: 9:30 a.m. - 10:30 a.m. and Unfractionated Heparin CME/CE Hours: 1 Wouter Kikkert, Bimmer EPM Claessen, Annemarie E. Engstrom, Marije Vis, Jan Baan, Jr., Martijn Meeuwissen, Robbert J. de Winter, 1046-282 Trends in the Prevalence of Acute Kidney Injury in Patients with Acute Myocardial Infarction Jan GP Tijssen, Jan J. Piek, Jose PS Henriques, Academic Medical Center Amsterdam, Amsterdam, The Netherlands Amit P. Amin, Kensey Riley, John A. Spertus, Lakshmi Venkitachalam, Learning Objective: Acknowkledge the influence of renal Joshua M. Stolker, Peter A. McCullough, Frederick A. Masoudi, insufficiency on anticoagulation levels and clinical outcome during Phillip G. Jones, Mikhail Kosiborod, Saint Luke’s Mid-America Heart treatment with unfractionated heparin in the setting of primary PCI. Institute, University of Missouri, Kansas City, MO Learning Objective: To identify the trends in the incidence of acute kidney injury over time in patients hospitalized with an acute myocardial infarction JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A103

1046-289 Impact of Renal Failure on Mortality, Stroke and 1047-293 Randomized Comparison of Prehospital Initiated Bleeding Complications in the Setting Of PCI for Facilitated PCI versus Primary PCI in Acute ACS or Stable Angina in Europe: Lessons From the Myocardial Infarction with < 3 h after Symptom Euro Heart Survey PCI Registry Onset

Anselm K. Gitt, Timm Bauer, Uwe Zeymer, Ralf Zahn, Franz Holger Thiele, Ingo Eitel, Claudia Meinberg, Gerd Plock, Wolfgang Weidinger, Matthias Hochadel, Christian Hamm, Euro Heart Strauß, Dietrich Pfeiffer, Andreas Hartmann, Gerhard Schuler, LIPSIA Survey PCI Registry, Institut f. Herzinfarktforschung Ludwigshafen, STEMI Group, University of Leipzig - Heart Center, Leipzig, Germany University of Heidelberg, Ludwigshafen, Germany, Herzzentrum Learning Objective: Demonstrate infarct size after different Ludwigshafen, Ludwigshafen, Germany reperfusion regimens Learning Objective: identify patients undergoing PCI at high risk 1047-294 Pre-Hospital Fibrinolysis Followed By Urgent Percutaneous Intervention within the First Two 1047 ACUTE MYOCARDIAL INFARCTION--CAN PRIMARY Hours of STEMI Are Associated With a Significant PCI BE FACILITATED? Reduction in Microvascular Obstruction and Infarct Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Size Georgia World Congress Center, Hall B5 Colin M. Barker, Lisa Torres, Daniel Maland, Eugene Stautberg, Presentation Hour: 9:30 a.m. - 10:30 a.m. John Ledoux, Catalin Loghin, Troy Weirick, Ali Denktas, H. Vernon CME/CE Hours: 1 Anderson, Stefano Sdringola, Richard W. Smalling, University of Texas Health Sciences Center at Houston, Houston, TX 1047-290 Upstream versus Deferred Administration of Small- Learning Objective: To identify the timing of a beneficial effect Molecule Glycoprotein IIb/IIIa Inhibitors in Primary of pre-hospital lytics and PCI as assessed by microvascular Percutaneous Coronary Intervention for ST-Segment obstruction. Elevation Myocardial Infarction: Insights from Randomized Clinical Trials 1048 ACUTE MYOCARDIAL INFARCTION--PRESERVING Lili Dong, Feng Zhang, Xianhong Shu, Institute of MICROVASCULAR FUNCTION AND PROMOTING Cardiovascular Diseases, Zhongshan Hospital, Fudan University, FAVORABLE REMODELLING Shanghai, People’s Republic of China Learning Objective: demonstrate that in STEMI patients scheduled Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. for primary PCI, upstream administration of smGPIs improves initial Georgia World Congress Center, Hall B5 epicardial patency before angioplasty, without an increase in major Presentation Hour: 9:30 a.m. - 10:30 a.m. bleeding risk. CME/CE Hours: 1

1047-291 Interaction Between Time to Treatment and Type of 1048-296 Intracoronary Nicorandil Can Improve Microvascular Reperfusion Therapy in STEMI: A Pooled Analysis of Dysfunction Following Primary Percutaneous One-Year Mortality in the Comparison of Angioplasty Coronary Intervention in Patients with ST-Segment & Prehospital Thrombolysis in Acute Myocardial

Elevation Myocardial Infarction: Its Superiority to Myocardial Ischemia Infarction (CAPTIM) and Which Early ST-elevation Intracoronary Nitroglycerin Myocardial Infarction Therapy (WEST) Trials and Infarction Noritoshi Ito, Shinsuke Nanto, Yasuji Doi, Hirotaka Sawano, Daisaku Cynthia M. Westerhout, Eric Bonnefoy, Robert C. Welsh, Florent Masuda, Shizuya Yamashita, Mai Hatano, Daisuke Tonomura, Yuma Boutitie, Philippe Gabriel Steg, Paul W. Armstrong, University of Kurozumi, Tomoaki Natsukawa, Yusuke Ito, Kazuyuki Oka, Jiro Ooba, Alberta, Edmonton, AB, Canada Taizo Hasegawa, Makoto Kobayashi, Hiroshi Ichiyanagi, Koji Akashi, Koichi Otsuya, Shoji kaibe, Ken-ichiro Okada, Yasuyuki Hayashi, Learning Objective: To identify optimal therapy, as it pertains to Tatsuro Kai, Toru Hayashi, Osaka Saiseikai Senri Hospital, Suita, the risk of long-term mortality, in ST-elevation myocardial infarction Japan, Osaka University Graduate School of Medicine, Suita, Japan patients according to their presentation delay. Learning Objective: identify the beneficial effect of intracoronary 1047-292 Optimal Timing of Percutaneous Coronary nicorandil, a hybrid K-ATP channel opener and nitric oxide donor, Intervention after Fibrinolysis in St-segment on microvascular dysfunction comparing with the efficacy of Elevation Myocardial Infarction: A Meta-analysis Nitroglycerin.

Steffen Desch, Ingo Eitel, Suzanne de Waha, Gerhard Schuler, 1048-297 Prognostic Value of Left Ventricular Sphericity after Holger Thiele, University of Leipzig Heart Center, Department of Acute Myocardial Infarction Internal Medicine/Cardiology, Leipzig, Germany Shinichi Okino, Shigeru Fukuzawa, Masayuki Inagaki, Juji Sugioka, Learning Objective: to determine the optimal timing of percutaneous Atsushi Ikeda, Jumpei Maekawa, Jumpei Maekawa, Soiciro Ichikawa, coronary intervention (PCI) in patients with ST-elevation myocardial Takashi Uchiyama, Norihiko Kamioka, Funabashi Municipal Medical infarction (STEMI) who have initially been treated with fibrinolysis. Center, Funabashi, Japan Learning Objective: find that left ventricular sphericity is a new and possibly important for the prognosis of acute myocardial infarction. A104 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1048-298 Effect of Nitroprusside on Reducing Infarct Size 1049-303 Impact of Admission Blood Glucose Level on After Primary Percutaneous Coronary Intervention Bleeding and Ischemic Complications in Patients for Acute Myocardial Infarction With Acute Myocardial Infarction: Analysis From the Harmonizing Outcomes With Revascularization and Hiroki Sakamoto, Shinsaku Shimamoto, Yuichi Kawase, Hiroshi Stents in Acute Myocardial Infarction Trial Ueda, Tomoe Murakami, Takashi Tamura, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan OLAYINKA AFOLABI-BROWN, Eugenia Nikolsky, Roxana Mehran, Learning Objective: Understand the effect of intracoronary LeRoy Rabbani, Martin Fahy, Selene Leon, Adriano Caixeta, Bruce nitroprusside injection during primary coronary intervention for R. Brodie, Dariusz Dudek, Martin Möckel, Andrzej Ochala, Gregg W. acute myocardial infarction. Stone, The Cardiovascular Research Foundation, New York, NY Learning Objective: identify the relationship between plasma 1048-299 Prognostic Value of Reverse Left Ventricular glucose on admission and outcomes of patients with ST-elevation Remodeling After Primary Percutaneous Coronary myocardial infarction treated with primary percutaneous coronary Intervention. intervention

Nazario Carrabba, Angela Migliorini, Renato Valenti, Guido Parodi, 1049-304 The Frequency, Etiology and Outcome of ST- Emilio V. Dovellini, David Antoniucci, Division of Cardiology, Careggi Elevation Myocardial Infarction Patients Requiring Hospital, Florence, Italy Urgent Coronary Artery Bypass Graft Learning Objective: interpret the clinical significance of reverse remodeling after primary PCI for STEMI Craig Tschautscher, David M. Larson, Timothy D. Henry, Jason T. Henry, Monique G. Ross, Robert S. Schwartz, Scott W. Sharkey, Thromboaspiration Before Primary PCI in STEMI Timothy J. Kroshus, Minneapolis Heart Institute Foundation at 1048-300 Abbott Northwestern Hosptial, Minneapolis, MN Patients Reduces Infarct Size, but Not Microvascular Obstruction: A Magnetic Resonance Imaging Study Learning Objective: Learn the incidence of emergency surgery in STEMI patients pretreated with Clopidogrel Nicolas F. Meneveau, Vincent Descotes-Genon, Romain Chopard, Joanna Dutheil, Marie-France Seronde, Florent Briand, Francois 1049-305 Effects of Oral Glucose-Lowering Drugs on Long Schiele, University Hospital Jean Minjoz, Besancon, France Term Outcomes in Patients With Diabetes Mellitus Learning Objective: describe the contribution of thromboaspiration and Non-ST Elevation Myocardial Infarction to outcome after PCI in STEMI and effect on microvascular obstruction Casper H. Jorgensen, Gunnar H. Gislason, Charlotte Andersson, Ole Ahlehoff, Mette G. Charlot, Steen Z. Abildstrom, Allan Vaag, Christian Torp-Pedersen, Peter R. Hansen, Department of Cardiology, 1049 ACUTE MYOCARDIAL INFARCTION--HIGH RISK Copenhagen University Hospital Gentofte, Hellerup, Denmark SUBSETS Learning Objective: Investigate the cardiovascular risk of individual glucose-lowering drugs in patients with Diabetes Mellitus and Non- Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. ST myocardial infarction Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. 1049-306 Which is Worst in Patients Undergoing Primary CME/CE Hours: 1 Angioplasty for Acute Myocardial Infarction? Hyperglycemia?, Diabetes Mellitus? or Both? 1049-302 Predictor, Impact, and Prognostic Factor of Angiographic No-reflow Phenomenon in Patients Mehmet Ergelen, Huseyin Uyarel, Gokhan Cicek, Turgay Isık, Treated with Drug-eluting Stent for Acute ST- Damirbek Osmonov, Zeki Y. Gunaydın, Mehmet Bozbay, Ayca Turer, Mehmet Gul, Gul B. Abanonu, Department of Cardiology, Siyami segment Elevation Myocardial Infarction Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey, and Infarction Youngkeun Ahn, Seo Na Hong, Nam Sik Yoon, Hae Chang Jeong, Department of Cardiology, Balıkesir University, School of Medicine, Myocardial Ischemia Doo Sun Sim, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Balıkesir, Turkey Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Learning Objective: We should focuse on NDH, and especially DH Kang, Chonnam National University Hospital, Gwangju, South Korea, patients. Global cardiometabolic risk control by intensive care Seonam University Hospital, Gwangju, South Korea should be a part of management in these patients. Learning Objective: investigate the predictor and prognostic factor for no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction treated with drug-eluting stent JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A105

1050 ACUTE MYOCARDIAL INFARCTION-- 1051 ACUTE MYOCARDIAL INFARCTION--PCI PERCUTANEOUS INTERVENTIONAL TECHNIQUES STRATEGIES Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1050-307 Radial Access during Primary Angioplasty in Acute 1051-313 Early PCI After Thrombolysis Versus Standard Myocardial Infarction. Experience of a Unique Therapy in STEMI Patients: a Cumulative Meta- Center in Southamerica analysis

Luis A. Pérez, Eduardo Lecannelier, Reinaldo Venegas, Jorge Federico Piscione, Warren J. Cantor, Francisco Fernandez-Aviles, Gajardo, Alvaro Saldaña, Jessica Parra, Virginia Segall, Isabel Sigrun Halvorsen, Michel Le-May, Paul W. Armstrong, Scheller Bruno, Robles, Guillemo Grant Benavente Hospital, Concepcion, Chile, Shaun G. Goodman, Konstantinos Dimopoulos, Francesco Borgia, School of Medicine, University of Concepcion, Concepcion, Chile Carlo Di Mario, Federico II University, Naples, Italy, Royal Brompton Hospital and The National Heart and Lung Institute, London, Italy Learning Objective: Know that transradial percutaneous coronary intervention during primary angioplasty for acute myocardial Learning Objective: demonstrate benefit of a routine invasive infarction is as safe and effective as femoral approach. strategy after lysis in STEMI patients

1050-308 Assessment Of The Safety And Performance Of The 1051-314 Short- and Long-term Outcomes of Systematic Stentys Self-expanding Coronary Stent System In Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction Patients who Develop Cardiogenic Shock after a ST- elevation Myocardial Infarction (STEMI) Christian Spaulding, Giovanni Amoroso, Stefan Verheye, Robert- Jan van Geuns, Karl Hauptmann, Martin Rothman, Shahrzad Bethany E. Durling, Michel R. Le May, Derek Y. So, Michael P. V. Sepehrkhouy, Hopital Cochin, Paris, France Fröeschl, Edward R. O’Brien, Marino Labinaz, Jean-François Marquis, Melissa Fong, George A. Wells, Chris A. Glover, University of Ottawa Learning Objective: Demonstrate continued vessel lumen increase Heart Institute, Ottawa, ON, Canada after implantation of a self-expanding stent for AMI treatment Learning Objective: Evaluate the mortality rates of patients who 1050-309 Long-term Efficacy And Safety Of Zotarolimus- developed cardiogenic shock after a STEMI in the setting of Primary Eluting Stent Versus Sirolimus-Eluting Stent In PCI Patients With ST-Elevation Myocardial Infarction Who Underwent Primary Percutaneous Coronary 1051-315 High-risk MI patients derive greatest absolute Intervention benefit from primary percutaneous coronary intervention: Results from the Primary Coronary Yoon Seok Koh, Ki-Bae Seung, Wook-sung Chung, Kiyuk Chang, Hun- Angioplasty Trialist Collaboration Jun Park, Eun-ho Choo, Jae-Sun Uhm, GeeHee Kim, Suk-Min Seo, Woo Baek Chung, Mahn Won Park, Min Seok Choi, Seung Jung Park, Sanneke P. De Boer, Liz Barnes, Cyntia W. Westerhout, John Simes, Myocardial Ischemia KAMIR invastigators, Seoul St. Mary’s Hospital, Seoul, South Korea Christopher B. Granger, Felix Zijlstra, Eric Boersma, ErasmusMC, Rotterdam, The Netherlands and Infarction Learning Objective: distinguish Learning Objective: We investigated which (categories of) MI 1050-310 Left versus Right Radial Access Provide Rapid and patients would benefit most of the strategy of PPCI, and thus have Equivalent Procedure Times for Primary PCI in lowest numbers needed to treat (NNTs). STEMI 1051-316 Time Distribution of Re-Infarction After Christopher T. Pyne, Peter Larsen, Cathy Jeon, Sergio Waxman, Thrombolysis: Relevance for Optimal Treatment Thomas Piemonte, Saumil Shah, Lahey Clinc Medical Center, Strategy in Acute Myocardial Infarction Burlington, MA Giovanna Giannotti, Paola Capozza, Silva Severi, Giovanni Micheli, Learning Objective: Demonstrate equivelence of radial access sites Marta Focardi, Mario Marzilli, Cardiac and Thoracic Department, in primary PCI for STEMI. University Hospital of Pisa, Pisa, Italy, Division of Cardiology, Misericordia Hospital, Grosseto, Italy 1050-311 In-Hospital and Long-Term Outcome of Primary Percutaneous Coronary Intervention for Acute Learning Objective: Identify the importance of a timely strategy to Myocardial Infarction due to Left Main Coronary combine benefit of PCI and thrombolysis in STEMI. Artery Occlusion

Takuya Izumikawa, Shingo Sakamoto, Satoshi Takeshita, Akihiko Takahashi, Shigeru Saito, Shonan Kamakura General Hospital, Kamakura, Japan, Sakurakai Takahashi Hospital, Kobe, Japan Learning Objective: Demonstrate In patients with AMI due to LMT- occlusion, successful reperfusion did not improve the survival when hemodynamic collapse existed upon arrival. A106 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1051-317 The Salvaged Area at Risk In Rescue Percutaneous 1052-323 Rosiglitazone Alters Characteristics of Ischemic Coronary Intervention: Quantification by Ventricular Fibrillation in Pigs Cardiovascular Magnetic Resonance Mohammad Sarraf, Li Lu, Ya Xu, Michael J. Reiter, Clifford Greyson, Jessica Sánchez-Quinones, Juan Miguel Ruiz-Nodar, Feliu Rey Gregory G. Schwartz, VA Medical Center and University of Colorado, Eloisa, Jose Valencia, Garcia-Carbonell Milagros, Patricio Perez- Denver, CO Berbel, Vicente Mainar Tello, Patricia Martin, Francisco Sogorb Garri, Learning Objective: describe the effects of anti-diabetic Hospital General Universitario de Alicante, Alicante, Spain thiazolidinedione drugs on characteristics of ischemic ventricular Learning Objective: To identify by means of Cardiovascular Magnetic fibrillation. Resonance (CMR) the salvaged area at risk in patients that underwent rescue PCI as well as to identify the variables in relation with the salvaged area. 1098 NOVEL BIOMARKERS FOR DIAGNOSIS AND RISK STRATIFICATION IN ACS

1052 NOVEL THERAPIES FOR CARDIOGENIC SHOCK Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 CME/CE Hours: 1 Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1098-256 Plasma Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels Measurement for 1052-319 Hemodynamic Assessment Of Impedance the Early Diagnosis of ST Elevation Myocardial Cardiography Compared With Clinical Evaluation Infarction: Comparative Study with Myocardial And B Type Natriuretic Peptide (BNP) In Patients Necroses Markers With Acute Heart Failure. Nobuaki Kobayashi, Noritake Hata, Yoshihiko Seino, Noriaki Kume, marcelo westerlund montera, Sabrina Pereira, Raphael Osugi, Yvana Takuro Shinada, Yasuhiro Takahashi, Kyoichi Mizuno, Chiba Hokusoh Pereira, Marcelo Diniz, Ana Luiza Silva, André Volschan, Evandro Hospital, Nippon Medical School, Chiba, Japan Mesquita, Procardiaco Hospital, Rio de Janeiro, Brazil Learning Objective: evalutate the usefulness of soluble lectin-like Learning Objective: Demonstrate that cardiography impedance oxidized low-density lipoprotein receptor-1 has an aditional value to clinic assessment through definition of hemodynamic condition in acute heart failure patients. 1098-257 Cytokine And Chemokine Expression Profile Within The Coronary Circulation Of Patients With Acute 1052-320 Acute Hemodynamic Changes Following Placement Coronary Syndromes. of TandemHeart Percutaneous Ventricular Assist Device for Refractory Cardiogenic Shock Paolo Golino, Raffaele De Palma, Elena D’Aiuto, Plinio Cirillo, Gianluca Petrillo, Paola Mariettta, Paolo Calabrò, Federico Piscione, Thomas M. Todoran, Sripal Bangalore, Alexandra Sims, Scott Kinlay, Massimo Chiariello, Second University of Naples, Naples, Italy, Andrew C. Eisenhauer, Piotr S. Sobieszczyk, Brigham and Women’s University of Naples “Federico II”, Naples, Italy Hospital, Boston, MA Learning Objective: Identify citokine production within the coronary Learning Objective: Demonstrate the acute hemodynamic changes circulation as an important pathophysiological mechanism in acute associated with insertion of TandemHeart percutaneous ventricular coronary syndromes assist device in patients with refractory cardiogenic shock. 1098-259 A Prognostic Proteomic Biomarker Algorithm for 1052-321 Incidence of Left Ventricular Systolic Dynamic Acute Myocardial Infarction: a Kaiser Permanente -

and Infarction Obstruction in Non-Cardiogenic Shock Treated with Orentreich Foundation Nested Case-Control study. Positive Ionotropic Agents. Myocardial Ischemia Carlos Iribarren, Charles P. Quesenberry, Evangelos Hytopoulos, Vikas Aggarwal, Elena Tessitore, Ujwal R. Neravetla, Jay S. Meisner, Bruce H. Phelps, Edward R. McCluskey, WuXiong Li, Huang Huang, Jacobi Medical Center, Bronx, NY Jeanne A. Darbinian, Norman Orentreich, Joseph Vogelman, Kaiser Learning Objective: Investigate whether treatment of non-cardiogenic Permanente Division of Research, Oakland, CA shock with vasopressors possessing positive ionotropic properties Learning Objective: Demonstrate the ability of a panel of can induce systolic dynamic obstruction of the left ventricle. inflammatory biomarkers to predict AMI

1052-322 Impact of Initial Recorded Rhythm on Cardiac 1098-260 Expansion of Th17 cells and IL-17 production are Arrest Patients Treated with Extracorporeal detectable in selected patients with Acute Coronary Cardiopulmonary Resuscitation Syndromes.

Eisuke Kagawa, Ichiro Inoue, Takuji Kawagoe, Masaharu Ishihara, Paolo Golino, Plinio Cirillo, Elena D’Aiuto, Danilo Rinaldi, Francesco Yuji Shimatani, Satoshi Kurisu, Yasuharu Nakama, Kazuoki Dai, Borriello, Gianfranco Abbate, Paolo Calabrò, Greta Luana D’Ascoli, Takayuki Otani, Hiroki Ikenaga, Yoshimasa Morimoto, Kentaro Ejiri, Raffaele Calabrò, Raffaele De Palma, Second University of Naples, Nozomu Oda, Hiroshima City Hospital, Hiroshima, Japan Naples, Italy, University of Naples “Federico II”, Naples, Italy Learning Objective: We demonstrated the neurological outcomes in Learning Objective: Identify Th17 cells as important contributor to the PEA-group and asystole-group patients were poor, but 2 patients plaque complication in the PEA-group achieved a favourable neurological outcome and returned to their forme JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A107

1098-261 Elevated Soluble Lectin-like Oxidized LDL 1099-266 Implications of Bundle Branch Block in Patients Receptor-1 (LOX-1) in Coronary Circulation of Undergoing Primary Angioplasty in the Stent Era: Patients with Acute Coronary Syndrome Short and Long-Term Prognosis

Hiroyuki Kunii, Yasuto Hoshino, Tomofumi Misaka, Hiroyuki David Vivas, Maria Jose Pérez-Vizcayno, Antonio Fernández-Ortiz, Mizukami, Nobuo Sakamoto, Koichi Sugimoto, Kazuhiko Nakazato, Camino Bañuelos, Javier Escaned, Pilar Jiménez-Quevedo, Ivan Yoshiko Fujita, Tetsuya Sawamura, Toshiyuki Ishibashi, Yasuchika Núñez-Gil, Juan Jose González-Ferrer, Rosana Hernández-Antolin, Takeishi, Department of Cardiology and Hematology, Fukushima Carlos Macaya, Fernando Alfonso, Cardiovascular Institute, San Medical University, Fukushima, Japan, Department of Vascular Carlos University Hospital, Madrid, Spain Physiology, National Cardiovascular Center Research Institute, Learning Objective: Identify higher risk patients with ST-segment Osaka, Japan elevation myocardial infarction Learning Objective: Demonstrate that soluble LOX-1 in coronary circulation is elevated in ACS 1099-267 New or Presumed New Left Bundle Branch Block in Patients with Acute Myocardial Infarction: Findings 1098-262 Identification of Salivary Biomarkers of Acute From ACTION Registry-GWTG Myocardial Infarction Using Classification and Regression Tree Analysis Khung Keong Yeo, Shuang Li, Tracy Y. Wang, Deepak L. Bhatt, Jorge Saucedo, Michael C. Kontos, Matthew T. Roe, William J. French, Joseph D. Foley, III, Charles L. Campbell, Craig S. Miller, J. Darrell University of California, Davis Medical Center, Sacramento, CA, Sneed, Alison L. Bailey, Dawn G. Dawson, Pierre N. Floriano, Harbor-UCLA Medical Center, Torrance, CA Nicolaos Christodoulides, Beate G. Rose, Jackie Singleton, Jeffrey Learning Objective: To describe the differences in clinical L. Ebersole, Steven Steinhubl, Denis F. Kinane, Richard J. Kryscio, presentation and outcomes in patients with acute myocardial M. John Novak, John T. McDevitt, Department of Internal Medicine, infarction presenting with left bundle branch block and ST-segment Cardiology Division, College of Medicine, University of Kentucky, elevation Lexington, KY

Learning Objective: To determine if salivary biomarkers could 1099-268 ST-resolution Following Primary Percutaneous help facilitate an earlier screening diagnosis of acute myocardial Coronary Intervention in Acute Myocardial Infarction infarction. is Associated With Early Recovery of Vagal Reflexes.

1098-263 The Impact Of Genetic Variability Of Fibrinogen Gaetano Maria De Ferrari, Antonio Sanzo, Grazia M. Castelli, A-Chain Gene Defines Fibrinogen Levels Between Annalisa Turco, Fabio Badilini, Peter J. Schwartz, Dept. of Cardiology Healthy Individuals And Patients With Documented - Fondazione IRCCS Policlinico San Matteo and University of Pavia, Atherosclerosis: Effects On Prothrombotic Profile Pavia, Italy, AMPS-llc, New York, NY Learning Objective: Acknowledge the possibility to measure vagal Nikos Papageorgiou, Dimitris Tousoulis, George Hatzis, Antigoni reflexes in acute myocardial infarction from spontaneous BP and Miliou, Charalambos Antoniades, Anastasios Giolis, Maria HR recordings. Assess the correlation between reperfusion and Kozanitou, Alexandros Briasoulis, Alexios Antonopoulos, Eirini recovery of vagal reflexes Bosinakou, Christodoulos Stefanadis, 1st Cardiology Unit Hippokration Hospital, Athens, Greece 1099-269 Patients with New or Presumably New Left Bundle Learning Objective: Evaluate the impact of the G58A polymorphism Branch Block Have a Low Rate of Acute Myocardial Myocardial Ischemia on fibrinogen levels and prothrombotic profile in patients with CAD Infarction and Infarction

Michael C. Kontos, Vinh Q. Chau, Charlotte S. Roberts, Joseph 1099 THE ELECTROCARDIOGRAM, CHEST PAIN P. Ornato, George W. Vetrovec, Virginia Commonwealth University, EVALUATION AND ACS OUTCOME Richmond, VA Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Learning Objective: Describe ECG criteria for diagnosing patients with LBBB and possible MI Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. 1099-271 Lateral ST-Segment Elevation Is a Strong Predictor CME/CE Hours: 1 of Impaired Myocardial Reperfusion in Patients with Inferior Acute Myocardial Infarction 1099-265 Association of Morphologic Variability with Ventricular Tachycardia and Ventricular Pause Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi, Satoshi Morita, in Patients Treated with Ranolazine or Placebo Kengo Tsukahara, Noriaki Iwahashi, Jyun Okuda, Kazuaki Uchino, Following Non-ST-Elevation Acute Coronary Toshiyuki Ishikawa, Satoshi Umemura, Kazuo Kimura, Yokohama Syndrome City University Medical Center, Yokohama, Japan Learning Objective: Evaluate the clinical significance of ST-segment Zeeshan Syed, Benjamin M. Scirica, David A. Morrow, Collin M. elevation in leads V5-6 in patients with recanalized inferior acute Stultz, John V. Guttag, University of Michigan, Ann Arbor, MI, TIMI myocardial infarction Study Group, Brigham and Women’s Hospital, Boston, MA Learning Objective: identify patients at increased risk of arrhythmia post-NSTEACS A108 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1099-272 ASia Pacific Evaluation of Chest pain Trial (ASPECT) 1100-277 One-Year Outcomes after Tirofiban Versus - New Zealand arm Abciximab Infusion in 745 Patients with St-segment Elevation Myocardial Infarction Undergoing Primary Sally Aldous, Martin Than, Mark Richards, Christchurch Hospital, Intervention: Insights from the Mltistrategy Trial Christchurch, New Zealand Learning Objective: identify low risk patients presenting to the Marco Valgimigli, Gianluca Campo, Matteo Tebaldi, Leonardo emergency department with symptoms suggestive of acute coronary Bolognese, Maurizio Anselmi, Salvatore Colangelo, Nicoletta De syndromes Cesare, Alfredo E. Rodriguez, Maurizio Ferrario, Raul Moreno, Cardiovascular Institute, University of Ferrara, Ferrara, Italy, Cardiovascular Research Centre, Salvatore Maugeri Foundation, 1100 ACUTE MYOCARDIAL INFARCTION--NEW IRCCS Gussago (BS), Gussago, Italy INSIGHTS INTO ANTIPLATELET THERAPY Learning Objective: evaluate long-term benefit of tirofiban treatment compared to abciximab in STEMI patients undergoing primary PCI Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 1100-278 Patients with Previous Definite Stent Thrombosis Presentation Hour: 3:30 p.m. - 4:30 p.m. Have a Larger Fraction of Immature Platelets and a CME/CE Hours: 1 Reduced Antiplatelet Effect of Aspirin

1100-273 Proton Pump Inhibitors are Associated with Morten Würtz, Erik L. Grove, Lise N. Wulff, Anne K. Kaltoft, Hans H. Cardiovascular Risk Independent of Clopidogrel Use Tilsted, Lisette O. Jensen, Anne-Mette Hvas, Steen D. Kristensen, in Patients with Myocardial Infarction: A Nationwide Aarhus University Hospital, Skejby, Aarhus, Denmark Propensity Score Matched Study Learning Objective: Patients with previous stent thrombosis have a reduced antiplatelet effect of aspirin compared to matched controls. Mette G. Charlot, Ole Ahlehoff, Casper H. Jorgensen, Steen Z. This might be caused by an increased platelet turnover. Abildstrom, Lars Køber, Peter R. Hansen, Christian Torp-Pedersen, Gunnar Gislason, Department of Cardiology,Gentofte Hospital, Comparison of Net Clinical Efficacy of Novel Copenhagen University Hospital, Hellerup, Denmark, The Heart 1100-279 Antiplatelet Agents for Acute Coronary Syndrome Centre, Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark Using Bayesian Analysis Learning Objective: Demonstrate that proton pump inhibitors are Christopher Lang, Rohit Arora, Chicago Medical School, Chicago, IL, associated with cardiovascular risk independent of clopidogrel use University of Rochester Medical Center, Rochester, NY in patients with myocardial infarction. Learning Objective: Interpret the net clinical efficancy using Bayesian analysis of novel antiplatelet agents 1100-274 The Incidence of Arrhythmias and Clinical Arrhythmic Events in Patients with Acute Coronary 1100-280 Aspirin Failure Is Associated with Worse Clinical Syndromes Treated with Ticagrelor or Clopidogrel in Outcome but Not with an Inadequate Platelet the PLATO Trial Response to Aspirin in Patients with Acute Benjamin M. Scirica, Christopher P. Cannon, Håkan Emanuelsson, Myocardial Infarction Robert A. Harrington, Steen Husted, Stefan K. James, Hugo Katus, Roy S. Beigel, Hanoch Hod, Boris Shenkman, Paul Fefer, Naphtali Eric L. Michelson, Pais Prem, Raev Dmitar, Jindrich Spinar, MD, Ph Savion, David Varon, Shlomi Matetzky, The Heart Institute, Sheba Gabriel Steg, Robert F. Storey, Lars Wallentin, TIMI Study Group, Medical Center, Tel Hashomer, Israel, Sackler School of Medicine, Brigham and Women’s Hospital, Boston, MA Tel Aviv University, Tel Aviv, Israel Learning Objective: To understand relationship between ticagrelor Learning Objective: To clarify the clinical significance and and bradycardic events pathogenesis of aspirin failure in patients with acute myocardial

and Infarction infarction. Ticagrelor Does Not Affect Pulmonary Function

Myocardial Ischemia 1100-276 Tests Compared to Clopidogrel in Acute Coronary Syndromes: Results of the Plato Pulmonary 1101 ACUTE MYOCARDIAL INFARCTION--TIMING Substudy ISSUES IN REPERFUSION THERAPY

Robert F. Storey, Richard C. Becker, Christopher P. Cannon, Frank Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Cools, Håkan Emanuelsson, Robert A. Harrington, Steen Husted, Georgia World Congress Center, Hall B5 Stefan James, Hugo Katus, Khurmi Nardev, Soo Teik Lim, Ph Gabriel Presentation Hour: 3:30 p.m. - 4:30 p.m. Steg, Lars Wallentin, University of Sheffield, Sheffield, United CME/CE Hours: 1 Kingdom, Uppsala Clinical Research Center, Uppsala, Sweden

Learning Objective: Understand the nature of dyspnea associated 1101-282 Does Weekend Effect of Myocardial Infarction Still with ticagrelor Exist - A Nationwide Analysis?

Nilay Kumar, Abhishek Deshmukh, Emily McGinley, Daniel Eastwood, Sergey Tarima, Gagan Kumar, Medical College of Wisconsin, Milwaukee, WI Learning Objective: Identify the discrepancies in the outcomes of myocardial infarction JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A109

1101-283 Ripple Effects of a Novel D2B Pathway 1102 VASCULAR BIOLOGY OF MYOCARDIAL ISCHEMIA/ Monica G. Sanchez-Ross, James M. Maher, Mike Kasper, Gerard INFARCTION Oghlakian, Brijesh Patel, Vivek N. Dhruva, Edo Kaluski, David Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Langley, William Dougan, Diane Alfano, Marc Klapholz, University of Medicine and Dentistry New Jersey, Newark, NJ Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: Identify a novel method for shortening D2B times CME/CE Hours: 1 Extent of Cholesterol Crystals in Coronary Artery 1101-284 Delays in Time to Reperfusion Therapy in Patients 1102-290 who develop ST-Elevation Myocardial Infarction Aspirates During Acute Myocardial Infarction During Hospitalization George S. Abela, Fadi Shamoun, Ameeth Vedre, Dorothy R. Pathak, Ibrahim Shah, Guarav Dhar, Dale Leffler, Michigan State University, Jeff Booker, Anthony Hilliard, Chris Bjerke, Heather Wiste, Ryan East Lansing, MI, Sparrow Hospital, Lansing, MI Lennon, Malcolm Bell, Charanjit Rihal, Bernard Gersh, David Holmes, Henry Ting, Mayo Clinic, Rochester, MN Learning Objective: This demonstrates the extent of cholesterol crystals in the aspirate obstructing the coronary artery. Learning Objective: identify the characteristics of patients developing STEMI while in-hospital and the challenges of providing timely reperfustion. 1102-291 ROCK2 Polymorphisms Are Not Associated With Vasospastic Angina

1101-285 Achieving First Door-to-Balloon Times of 90 Minutes Sang-Yong Yoo, Joung-Wook Kim, Sangsig Cheong, Dae-Hee Shin, for Transfer ST-Elevation Myocardial Infarction Jinkun Jang, Changkun Lee, Kyoung-Hee Kim, University of Ulsan College of Medicine Gangneung Asan Hospital, Gangneung, South B. Hadley Wilson, Angela D. Humphrey, Robert H. Haber, John Korea C. Cedarholm, Glen K. Kowalchuk, Michael J. Rinaldi, William E. Downey, Kevin M. Collier, Patricia M. Pye, Denise A. Miller, Jennifer Learning Objective: demonstrate that ROCK2 polymorphisms may L. Sarafin, Tom Blackwell, J. Lee Garvey, Carolinas Medical Center, not associated with the pathogenesis of vasospastic angina. Charlotte, NC Learning Objective: Identify components essential to improving 1102-292 Erythropoietin Enhances Arginase Ii Activity Against transfer STEMIs first door-to-balloon times Nitric Oxide Synthase Mediated Nitrosative Stress In Rat Post-ischemic Hearts

1101-286 False Positive Catheterization Laboratory Activation Yih-Sharng Chen, Ming-Chieh Ma, National Taiwan University Rates in the RACE Regional ST Elevation Myocardial Hospital, Taipei, Taiwan,ROC, Fu Jen Catholic University, Taipei, Infarction Program Taiwan,ROC James G. Jollis, J. Lee Garvey, Lisa Monk, Jonathan R. Studnek, Learning Objective: At the conclusion of this presentation, Mayme L. Roettig, Christopher B. Granger, Duke University, Durham, participants will be able to understand a novel mechanism of NC, Carolinas Medical Center, Charlotte, NC erythropoietin-mediated cardioprotection Learning Objective: Understand benchmark rates for cath. lab activation accuracy 1102-293 Correlation Between Microvascular Obstruction Myocardial Ischemia And Index Of Microcirculatory Resistance For and Infarction Assessment Of Microvascular dysfunction In 1101-288 The Importance Of Pre-hospital Infarct Diagnosis And Therapy On Initial Patency Of The Infarct Patients With Acute Myocardial Infarction Related Vessel Before PCI In Patients With Stemi Jong Hoon Koh, Duk Kyu Cho, Hee Woo Lee, Miyoung Kim, Sonja Postma, J.H.E. Dambrink, M.J. De Boer, A.T.M Gosselink, J.P. Kwandong University Mongji Hospital, Goyang, South Korea, Goyang, Ottervanger, J.C.A. Hoorntje, E. Kolkman, H. Suryapranata, A.W.J. South Korea Van ‘t Hof, Diagram B.V., Zwolle, The Netherlands Learning Objective: microvascular dysfunction Learning Objective: Demonstrate that pre-hospital infarct diagnosis with concomitant early initiation of aspirin and heparin is associated 1102-294 Association of Morphological Characteristics of with improved initial patency of the infarct related vessel before PCI. Culprit Atheromatic Plaques With the Outcome of Thrombolytic Therapy: New Implications of Optical 1101-289 Late Open for Infarct-Related Artery Still Work Coherence Tomography Better Than Not for Patients with Acute Myocardial Konstantinos Toutouzas, Elefterios Tsiamis, Antonis Karanasos, Infarction: A 15-year Survival Analysis Maria Drakopoulou, Andreas Synetos, Maria Riga, Costas Tsioufis, Ta-Chen Su, Ming-Fong Chen, Juey-Jen Hwang, Tsun-Den Tseng, Dimitrios Tousoulis, Elli Stefanadi, Christodoulos Stefanadis, 1st Hsian-Li Kao, Yuan-Teh Lee, Chiau-Suong Liau, Division of Department of Cardiology, Hippokration Hospital, Athens, Greece Cardiology, Department of Internal Medicine, National Taiwan Learning Objective: gain new insight about the impact of plaque University Hospital, Taipei, Taiwan,ROC, Cardiovascular Center, Tzu- morphology on the outcome of thrombolytic therapy. Chi Hospital, Hsin-Dian, Taipei, Taiwan,ROC Learning Objective: The better treatment strategies in patients with AMI A110 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1103 MYOCARDIAL ISCHEMIA/INFARCTION: CELL- 1104 MYOCARDIAL ENERGETICS AND PROTECTION BASED THERAPY Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1 1104-302 Abnormal Myocardial Energetics in Chronic 1103-296 Myocardial Perfusion After Intracoronary Infusion Hibernating Myocardium at High Cardiac Work Load of Mononuclear Cells of Bone Marrow or Peripheral Mohammad N. Jameel, Qiang Xiong, Qinglu Li, Abdul Mansoor, Jianyi Blood After Acute Myocardial Infarction Zhang, University of Minnesota, Minneapolis, MN Farshid Afsharzada, Robin Nijveldt, Alexander Hirsch, Pieter A Learning Objective: describe myocardial energetics in chronic van der Vleuten, Aernout M. Beek, Jan G.P. Tijssen, Jan J. Piek, hibernating myocardium. Felix Zijlstra, Albert C. van Rossum, VU University Medical Center, Amsterdam, The Netherlands, Interuniversity Cardiology Institute of 1104-303 Exercise Training Improves Cardiac FunctionThrough the Netherlands, Utrecht, The Netherlands Increase In Autophagosome Degradation And Fatty Learning Objective: evaluate the effects of intracoronary infusion Acid Uptake of mononuclear cells on the recovery of myocardial perfusion after reperfused acute myocardial infarction (AMI) Bai-Chin Lee, Ching-Yi Chen, Hsiu-Ching Hsu, Ming-Fong Chen, National Taiwan University Hospital, Taipei, Taiwan,ROC 1103-297 Transplantation Of Cardiogenic Cells Differentiated Learning Objective: identify the role of exercise on cardiac From Mesenchymal Stem Cells Improves Cardiac autophagosome degradation and fatty acid uptake Repair In Ischemic Hearts 1104-304 Cardioprotective Effects of α1-Antitrypsin in Ki-Chul Hwang, Byeong-Wook Song, Heesang Song, Min-Ji Cha, Experimental Acute Myocardial Infarction due to Eunju Choi, Onju Ham, Namsik Chung, Yangsoo Jang, Cardiovascular Transient Ischemia in the Mouse Research Institute, Division of Cardiology, Yonsei University College of Medicine, Seoul, South Korea Antonio Abbate, Benjamin W. Van Tassell, Ignacio M. Seropian, Learning Objective: demonstrate Stefano Toldo, Lisa Smithson, Charles A. Dinarello, Virginica Commonwealth University, Pauley Heart Center, Richmond, VA, University of Colorado, Arora, CO 1103-298 Endothelial Colony-Forming Cells are Associated With Infarct Size Reduction Through Reduction of Learning Objective: To learn that AAT is an endogenous anti- Microvascular Obstruction inflammatory protein able to protect the heart during ischemic injury

Nicolas F. Meneveau, Frederic Deschaseaux, Vincent Descotes- 1104-305 The Aging Heart is Susceptible to Cardiomyocyte Genon, Francois Schiele, Pierre Tiberghien, Jean-Pierre Bassand, Apoptosis and Resistant to Anti-Apoptotic Therapies Siamak Davani, University Hospital Jean Minjoz, Besancon, France, INSERM U645, Etablissement Français du Sang Bourgogne Franche- Joy I. Hwang, Henry H. Shih, Brian Lee, Yan Zhang, Jianqin Ye, Comté, Besancon, France Richard E. Sievers, Eddie Rame, William Grossman, Randall J. Lee, Learning Objective: describe the mechanism by which endothelial Yerem Yeghiazarians, Andrew J. Boyle, University of California, San progenitor cells improve left ventricular remodeling after MI Francisco, San Francisco, CA Learning Objective: identify the difference in apoptosis between 1103-299 Human Umbilical Cord Blood Stem Cells Secrete young and old mice, as well as understand the importance of Growth Factors and Anti-Inflammatory Cytokines creating a well-characterized aging mouse model. and Infarction that Protect Vascular Endothelial Cells and Cardiac Myocardial Ischemia Myocytes from Ischemia and Injury 1104-306 Cardioprotective Effects of PPARγ in the Developing Heart Robert J. Henning, Darrell Sawmiller, David Fleming, Lorynn Hunter, Jeffrey Aufman, Michael B. Morgan, James A. Haley Hospital, Tampa, Xiaoping Jin, Brian Crawford, Ming Shen, Ronald W. Joyner, Mary B. FL, University of South Florida College of Medicine, Tampa, FL Wagner, Guoliang Ding, Departemnt of Pediatrics, Emory University, Atlanta, GA, Children’s Healthcare of Atlanta, Atlanta, GA Learning Objective: identify that stem cells have paracrine effects that limit apoptosis and necrosis in myocardial infarction Learning Objective: Demonstrate

1103-300 Hypoxia Accelerates and Enhances Cardiomyogenesis in Mesenchymal Stem Cells: An Environmental Cue for a Cardiac Challenge

Arti A. Ramkisoensing, Daniel A. Pijnappels, Antoine A. de Vries, Arnoud van der Laarse, Martin J. Schalij, Douwe E. Atsma, Leiden University Medical Center, Leiden, The Netherlands Learning Objective: to identify the importance of local environmental cues on the regenerative potential of MSCs in cardiac cell therapy JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A111

1105 HYPOTHERMIC THERAPY FOR CARDIAC ARREST 1106 PRE-HOSPITAL EMERGENCY THERAPIES FOR CARDIAC ARREST Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 CME/CE Hours: 1 Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1105-307 Early Induction of Hypothermia Therapy Prior to Revascularization Therapy Improved Neurologic 1106-313 Increasing Trend of Pre-Transport Death of Heart Outcomes in Cardiac Arrest Caused by Acute Attack in the United States From 2000 to 2006 Coronary Syndrome: J-PULSE- Hypo Registry. Shifan Dai, Jing Fang, Nora L. Keenan, Robert K. Merritt, Centers for Shinichi Shirai, Kenji Ando, Yoshimitsu Soga, Kyohei Yamaji, Disease Control and Prevention, Atlanta, GA Tatsuki Doijiri, Masahiko Goya, Masashi Iwabuchi, Hiroyoshi Yokoi, Learning Objective: demonstrate that, in the most recent years, Hideyuki Nosaka, Masakiyo Nobuyoshi, Naohiro Yonemoto, Hiroyuki the proportion of heart attack deaths that occurred before patients Yokoyama, Hiroshi Nonogi, Ken Nagao, Kokura Memorial Hospital, were being transported to a hospital increased substantially in US. Kitakyushu, Japan

Learning Objective: interpret that early induction of hypothermia 1106-314 Regional Brain Oxygen Saturation as a Novel Index therapy prior to percutaneous intervention was effective to achieve of Neurological Outcomes in Patients With Out-of- favorable neurologic outcome Hospital Cardiogenic Cardiac Arrest

1105-308 Rapid Isolated Moderate Bilateral Cerebral Noritoshi Ito, Shinsuke Nanto, Yasuji Doi, Hirotaka Sawano, Daisaku Hypothermia Achieved With a Self Insulating Masuda, Shizuya Yamashita, Mai Hatano, Daisuke Tonomura, Yuma Catheter System Kurozumi, Tomoaki Natsukawa, Yusuke Ito, Kazuyuki Oka, Jiro Ooba, Taizo Hasegawa, Makoto kobayashi, Hiroshi Ichiyanagi, Koji Akashi, David Meerkin, Sarai Mckemie, Glen Lieber, Ronald J. Solar, Shaare Koichi Otsuya, Shoji Kaibe, Ken-ichiro Okada, Yasuyuki Hayashi, Zedek Medical Center, Jerusalem, Israel Tatsuro Kai, Toru Hayashi, Osaka Saiseikai Senri Hospital, Suita, Japan, Osaka University Graduate School of Medicine, Suita, Japan Learning Objective: Demonstrate the ability to achieve bilateral moderate cerebral hypothermia using a single carotid artery Learning Objective: identify that regional brain oxygen saturation catheter approach and evaluate the systemic temperature effects of (rSO2) can be used as a new useful index for estimating the this intervention neurological prognosis in patients with out-of-hospital cardiogenic cardiac arrest. 1105-309 Induced Hypothermia Improves Survival in Cardiac Arrest Patients 1106-315 Obtaining a Pre-hospital Electrocardiogram by Emergency Medical Personnel Shortens Total Michael C. Y. Chan, Carolyn Hoffman, William Hui, Demetrios J. Ischemic Time for ST Elevation Myocardial Kutsogiannis, Punkiat Topipat, Randy Williams, Royal Alexandra Infarction Patients Hospital, Edmonton, AB, Canada, University of Alberta, Edmonton, AB, Canada Mitul Patel, James Dunford, Steve Aguilar, Edward Castillo, Ehtisham Myocardial Ischemia Learning Objective: At the conclusion of this presentation, Mahmud, University of California San Diego, San Diego, CA, City of participants will be able to evaluate the usefulness of Induced San Diego EMS, San Diego, CA and Infarction Hypothermia for Cardiac Arrest patients, as well select appropriate Learning Objective: Appreciate the impact of pre-hospital patients for this treatment. electrocardiography in reducing total ischemic time for STEMI patients 1105-310 The Prevalence and Prognostic Value of Myoclonus and Status Epilepticus Prior to or Following 1106-316 The Earlier, the Better Therapuetic Hypothermia in Patients After Cardiac Arrest Tomoki Shokawa, Koichi Tanigawa, Ken Ishibashi, Takenori Okada, Kenji Nishioka, Yukiko Nakano, Hiroki Teragawa, Futoshi Tadehara, Michael Bryant Kelley, James A. Wantuck, Kathleen Burns, John A. Hideya Yamamoto, Tkafumi Ishida, Yasuki Kihara, Hiroshima McPherson, Vanderbilt Heart and Vascular Institute, Nashville, TN University, Hiroshika, Japan Learning Objective: describe the prevalence and prognostic impact of seizures in patients resuscitated from in-hospital and out of 1106-317 CPR Before Defibrillation for Out-of-Hospital Cardiac hospital cardiac arrest and treated with therapeutic hypothermia. Arrest: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials 1105-311 Faster, Cooler, Better? A Comparison of Two Methods for Instituting Mild Therapeutic Pascal Meier, Hitinder S. Gurm, Bettina Henzi, Ozlem Ozdemir, Hypothermia in Comatose Out of Hospital Cardiac Stanley Chetcuti, Paul M. Grossman, Guido Knapp, University of Arrest Patients Michigan Medical Center, Ann Arbor, MI Learning Objective: Our data demonstrate that current evidence Maximilian Mulder, Stephen W. Smith, Bradley A. Bart, Hennepin clearly advocates immediate defibrillation. County Medical Center, Minneapolis, MN Learning Objective: To determine which clinical approach to therapeutic hypothermia achieves target temperatures faster: surface or intravascular cooling? A112 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1107 PLATELETS AND INFLAMMATION IN MYOCARDIAL 1152 MRI: NEW DEVELOPMENTS IN CMR ISCHEMIA/INFARCTION Monday, March 15, 2010, 9:30 am - 12:30 pm Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. – 10:30 a.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1 1152-256 Cardiac Causes of One-Year Readmission Following 1107-319 Clopidogrel and Aspirin versus Aspirin Alone in Percutaneous Coronary Intervention (PCI) for High-Risk Patients with Established Vascular Ischemic Heart Disease: Retrospective Analysis of a Disease; A Meta-Analysis of Randomized Controlled Single-System Patient Cohort Trials Vipul Gupta, Anwar Tandar, Harpreet Bhutani, Dmitriy Kireyev, Clifford Swapna Kamireddy, Marc S. Sabatine, Deepak L. Bhatt, Steven R. Graves, William E. Boden, University at Buffalo, Buffalo, NY Steinhubl, William E. Boden, University at Buffalo, Buffalo, NY Learning Objective: Demonstrate high rate of cardiac cause of Learning Objective: To show the benefits and risks of early readmission after successful initial PCI within 1 year of follow up. clopidogrel and aspirin in high-risk patients with established vascular disease. 1152-257 Clinical Presentation and Plaque Morphology in Unstable Angina Pectoris: An Optical Coherence 1107-320 Perioperative Clopidogrel Cessation and Risk of Tomography Study Adverse Cardiovascular Events Masato Mizukoshi, Takashi Kubo, Atsushi Tanaka, Shigeho Beau Michael Hawkins, Michael Koehler, Pedro Lozano, University of Takarada, Hironori Kitabata, Takashi Tanimoto, Akio Kuroi, Hideyuki Oklahoma Health Sciences Center, Oklahoma City, OK Ikejima, Kenichi Komukai, Yasushi Ino, Kumiko Hirata, Hiroto Learning Objective: Understand the significant risk that Tsujioka, Keishi Okochi, Manabu Kashiwagi, Yuichi Ozaki, Aiko perioperative clopidogrel discontinuation poses to patients receiving Shimokado, Toshio Imanishi, Takashi Akasaka, Wakayama Medical noncardiac surgery University, Wakayama, Japan Learning Objective: interpret the association of the etiology and 1107-321 The Platelet Inhibition and Patient Outcomes Trial clinical presentation in primary unstable angina Is Representative of Patients With Acute Coronary Syndromes in a National Heart Registry 1153 OUTCOMES AFTER PERCUTANEOUS CORONARY Ulf Stenestrand, Saga Johansson, Magnus Janzon, Lars Wallentin, INTERVENTION Department of Cardiology, University Hospital, Linköping, Sweden Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Learning Objective: compare the patient population enrolled in Georgia World Congress Center, Hall B5 the PLATelet inhibition and patient Outcomes (PLATO) trial with an unselected ACS population seen in a national heart registry Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1107-322 Proteomic Analysis of Circulating Human Platelets Reveals Potential Biomarkers in non-ST Segment 1153-259 Coronary Angiogram Findings in Patients Who Elevation Acute Coronary Syndrome Abuse Amphetamines: a Retrospective Analysis

José Ramón González-Juanatey, Andrés F. Parguiña, Isaac Rosa, Christopher B. Seaman, Zhongmin Li, Garrett B. Wong, UC Davis Lilián Grigorian-Shamagián, Elvis Teijeira-Fernández, Jana Alonso, Medical Center, Sacramento, CA Rosa Agra, Ángel García, Universidade de Santiago de Compostela, Learning Objective: describe the effects of amphetamine use on and Infarction Santiago de Compostela, Spain, Complexo Hospitalario coronary artery disease.

Myocardial Ischemia Universitario de Santiago, Santiago de Compostela, Spain Learning Objective: understand how platelet proteomics can be 1153-260 Is Visual Interpretation of Coronary Epicardial used in cardiovascular research Flow Reliable in ST Elevation Myocardial Infarction Patients Undergoing Primary Angioplasty? Insights 1107-323 Increased Baseline Rho Kinase (ROCK) Activity is an from APEX-AMI Independent Predictor of 6 Month Cardiovascular Outcomes After Acute Coronary Syndrome (ACS) Osama Al-Hadramy, Cynthia M. Westerhout, Sorin J. Brener, Christopher B. Granger, Paul W. Armstrong, University of Alberta, Ming Dong, Mang Zhang, Rui-Jie Li, Qian-Huan Zhang, James K. Edmonton, AB, Canada Liao, Cheuk-Man Yu, The Chinese University of Hong Kong, Hong Learning Objective: To assess observer bias in estimation of TIMI Kong, Hong Kong, Brigham and Women’s Hospital and Harvard flows in STEMI pts undergoing primary PCI Medical School, Boston, MA Learning Objective: observe that baseline ROCK activity may be a potential independent predictor for the future cardiovascular outcomes JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A113

1153-261 Angiographic Characteristics of Coronary Stent 1154-268 Effect Of Cilostazol Adding Or Clopidogrel Doubling Thrombosis On Platelet Function With Diabetes Mellitus And Coronary Artery Disease On Dual Antiplatelet William Bennett, Khung Keong Yeo, Jason H. Rogers, Reginald I. Therapy Low, Etisham Mahmud, University of California San Diego, San Diego, CA, University of California Davis, Sacremento, CA Sang Jin Ha, Weon Kim, Jong Shin Woo, Tae-Kyung Yu, Soo Joong Learning Objective: Identify Agniographic characteristic of in stent Kim, Woo-Shik Kim, Myeong Kon Kim, Kwon Sam Kim, Kyunghee thrombosis. University Medical Center, seoul, South Korea Learning Objective: demonstrate that adjunctive treatment with 1153-262 Trends and Predictors of Length of Stay after cilostazol in T2DM patients on standard dual antiplatelet therapy Primary Percutaneous Coronary Intervention: A was strategy for overcoming clopidogrel resistance. Report from the National Cardiovascular Data Registry 1154-269 Impact of Prior Chronic Antiplatelet Therapy on Short- and Long-term Adverse Events in Patients Chee Tang Chin, Tracy Y. Wang, David Dai, Matthew T. Roe, Rajendra Presenting with an Acute Coronary Syndrome: H. Mehta, John S. Rumsfeld, H. Vernon Anderson, William S. Insights from the Acuity Trial Weintraub, John C. Messenger, Michael A. Kutcher, Ralph G. Brindis, Eric D. Peterson, Robert A. Harrington, Sunil V. Rao, Duke Clinical Giuseppe Ambrosio, Steven R. Steinhubl, Paolo Gresele, Isabella Research Institute, Durham, NC Tritto, Maurizio Bentivoglio, Cinzia Zuchi, David A. Cox, Brent T. Learning Objective: Identify temporal trends and predictors of length McLaurin, Jeffrey W. Moses, Harvey D. White, Frederick Feit, Philip E. of stay after primary percutaneous coronary intervention Aylward, Antonio Colombo, Harald Darius, Ramin Ebrahimi, Martial Hamon, Roxana Mehran, Gregg W. Stone, University of Perugia School of Medicine, Perugia, Italy 1154 PLATELET RESPONSIVENESS: ANTIPLATELET Learning Objective: appreciate the different, more severe risk profile THERAPY typical of chronic antiplatelet users who get hospitalized for an episode of Non-ST elevation acute coronary syndrome. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 1154-271 Effect of Proton Pump Inhibitors On Outcome Of Presentation Hour: 9:30 a.m. - 10:30 a.m. Patients Discharged On Dual Antiplatelet Therapy CME/CE Hours: 1 After Percutaneous Coronary Intervention And Stent Implantation 1154-265 Association of Platelet Responsiveness with Clopidogrel Metabolism: Role of Compliance in the Ioannis Tentzeris, Rudolf Jarai, Serdar Farhan, Ivan Brosovic, Peter Assessment of “Resistance” Smetana, Alexander Geppert, Jolanta Siller-Matula, Kurt Huber, 3rd Medical Department with Cardiology and Emergency Medicine, Victor Serebruany, Ganesh Cherala, Craig Williams, Wiktor Wilhelminen Hospital, Vienna, Austria, Department of Clinical Kuliczkowski, Dan Atar, Johns Hopkins University, Towson, MD Pharmacology, University of Medicine, Vienna, Austria Learning Objective: Define the frequency of clopidogrel non Learning Objective: identify the effect of proton pump inhibitors on compliance among patients with coronary artery disease and antiplatelet therapy ischemic stroke Myocardial Ischemia

1154-272 Comparison of High-Dose (600mg) vs. Moderate- and Infarction 1154-266 ABCB1 Genetic Variants, Pharmacodynamic Dose (300mg) Clopidogrel Loading in Patients Response, and Cardiovascular Outcomes Following Receiving Drug-Eluting Stents: A Subanalysis of a Treatment with Clopidogrel and Prasugrel Randomized Trial

Jessica L. Mega, Sandra L. Close, Stephen D. Wiviott, Lei Shen, O Sung Kwon, Seung-Jung Park, Asan medical center, Seoul, South Joseph R. Walker, Elliott M. Antman, Eugene Braunwald, Marc Korea S. Sabatine, TIMI Study Group, Brigham and Women’s Hospital, Boston, MA Learning Objective: Identify the role of genetic variants in ABCB1 on platelet inhibition and outcomes in the setting of treatment with clopidogrel.

1154-267 Cytochrome P450 2C19 Loss-of-function Polymorphism And Cardiovascular Events In Patients Treated With Drug-eluting Stent

Il-Young Oh, Chang-Hwan Yoon, Seung-Jung Park, Kyung-Woo Park, Hae-Young Lee, Hyun-Jai Cho, Hyun-Jai Kang, Hyo-Soo Kim, Seoul National University Hospital, Seoul, South Korea Learning Objective: This study demonstrated the strong correlation between CYP2C19 loss-of-function polymorphism and cardiovascular events in patients treated with drug-eluting stent. A114 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1155 NEW INSIGHTS IN TREATMENT OF ACUTE 1155-279 Single-center Evaluation of Epidemiology and CORONARY SYNDROMES Treatment of Patients With Acute Coronary Syndrome and Non Obstructive Coronary Artery Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Disease in the Real Life Georgia World Congress Center, Hall B5 Gaetano Maria De Ferrari, Sergio Leonardi, Lara Baduena, Presentation Hour: 9:30 a.m. - 10:30 a.m. Alessandra Repetto, Enrico Chieffo, Angela Lesce, Maddalena CME/CE Hours: 1 Lettino, Mario Previtali, Dept. of Cardiology - Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy, Dept. of 1155-273 Impact of Anticoagulation Regimen in Patients Cardiology University of Piemonte Orientale, Novara, Italy with Non-ST-Elevation Acute Coronary Syndromes Learning Objective: Acknowledge the existence of patients with Undergoing an Early Invasive Strategy Independent acute coronary syndrome and non obstructive coronary artery of Revascularization: The ACUITY Trial disease and estimate the prevalence of this condition. Tobias Geisler, Meinrad Gawaz, Steven R. Steinhubl, Michel E. Bertrand, A. Michael Lincoff, Angel R. Cequier, Walter Desmet, 1155-280 Threshold Level of Low-density Lipoprotein Lars H. Rasmussen, James Hoekstra, Roxana Mehran, Gregg Cholesterol for the Effect of Statin Therapy in the W. Stone, Royal Brompton Hospital / Imperial College, London, Acute Phase of Myocardial Infarction: An Analysis United Kingdom, Klinikum der Eberhard-Karls-Universität Tübingen, from the Korea Acute Myocardial Infarction Registry Tübingen, Germany Jang Hoon Lee, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Learning Objective: distinguish the benefits of initiating bivalirudin Shung Chull Chae, Jae-Eun Jun, Wee-Hyun Park, Young Jo Kim, Kee- monotherapy early in the NSTEMI ACS patient compared to heparin Sik Kim, Seung Ho Hur, Myung Ho Jeong, Korea Acute Myocardial + a GPI. Infarction Registry Investigators, Kyungpook National University Hospital, Daegu, South Korea Effects of Varespladib Methyl on Biomarkers and 1155-274 Learning Objective: evaluate the threshold level of LDL-C in which Major Cardiovascular Events in Acute Coronary statin therapy is no longer effective for reducing major adverse Syndrome Patients cardiac events in patients with myocardial infarction Robert S. Rosenson, Colin Hislop, SUNY Downstate, Brooklyn, NY, Anthera, Hayward, CA 1156 PREDICTING RISK OF ISCHEMIC EVENTS AND Learning Objective: Describe role of secretory phospholipase A2 BLEEDING IN ACS in lipoprotein remodeling, activation of inflammatory pathways and potential use in acute cardiovascular syndromes. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 1155-276 Increased Risk of Cardiac Ischemia and Arterial Presentation Hour: 9:30 a.m. - 10:30 a.m. Thromboembolic Events in Cancer Patients Treated CME/CE Hours: 1 with Bevacizumab: A Meta-Analysis

Vishal Ranpura, Jeff Chuang, Shenhong Wu, Stony Brook University 1156-282 Comparison Of The HEART, TIMI And GRACE Risk Hospital, Stony Brook, NY Scores For Chest Pain Patients At The Emergency Room Learning Objective: know the risk of Myocaridal infarction and other arterial thromboembolic events associated with use of Bevacizumab Barbra E. Backus, A. J. Six, J. C. Kelder, T. P. Mast, F. vanden Akker, H. W. de Beaufort, E. G. Mast, P. A. Doevendans, St Antonius 1155-277 Impact Of Combined Therapy Of Clopidogrel And Hospital, Nieuwegein, The Netherlands, University Medical Center, Atorvastatin With Perindopril And Valsartan On Utrecht, The Netherlands Inflammatory Markers And Prognosis In Patients and Infarction Learning Objective: identify low risk and high risk chest pain With Unstable Angina. patients with the use of the HEART score Myocardial Ischemia Anahit Gabrielyan, Rudolf Semyon RS. Gabrielyan, Ashot Vardan Differential Performance of the Global Registry of Davtyan, Institute Of Cardiology, Yerevan, Armenia 1156-283 Acute Coronary Events (GRACE) Risk Score Among Asian Ethnic Groups: A GRACE Model Discrimination 1155-278 Upstream versus Downstream Administration of and Calibration Study of 13,041 Asian Subjects Glycoprotein IIb/IIIa Inhibitors in Patients with Non- Mark Y. Chan, Bimal R. Shah, Fei Gao, Ling Ling Sim, Terrance Chua, ST-Elevation Acute Coronary Syndromes: A Meta- Huay Cheem Tan, Tiong Cheng Yeo, Hean Yee Ong, Keng Thye Ho, Analysis of Randomized Trials Ping Ping Goh, Soondal K. Surrun, Tian Hai Koh, Karen S. Pieper, E Shyong Tai, National University Heart Centre, Singapore, Singapore, Alessandro Sciahbasi, Giuseppe Biondi Zoccai, Enrico Romagnoli, National Heart Centre, Singapore, Singapore Ernesto Lioy, Policlinico Casilino - ASL RMB, Rome, Italy, University of Turin, Turin, Italy Learning Objective: Describe the performance of the GRACE model in Asian populations Learning Objective: compare the efficacy of the upstream or downstream use of glycoprotein IIb/IIIa in acute coronary syndromes JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A115

1156-284 Comparison of GRACE Risk Score Versus TIMI 1157 MECHANISMS OF ISCHEMIC INJURY AND Risk Score on Angiographic Findings in Patients PROTECTION With Non-ST-Segment Elevation Acute Coronary Syndrome Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Tatsuya Nakachi, Masami Kosuge, Kiyoshi Hibi, Toshiaki Ebina, Kengo Tsukahara, Jun Okuda, Satoshi Morita, Tetsuji Kaneko, Presentation Hour: 9:30 a.m. - 10:30 a.m. Satoshi Umemura, Kazuo Kimura, Yokohama City University Medical CME/CE Hours: 1 Center, Yokohama, Japan Non-invasive Imaging of the Localization and Learning Objective: evaluate the relation between GRACE and TIMI 1157-290 Time Course of Cell Death in a Canine Model of scores and angiographic findings in patients with non-ST-segment elevation acute coronary syndrome. Acute Myocardial Infarction and Reperfusion: Demonstration of Early and Late Phases of Reperfusion Cell Death 1156-285 Left Atrial Function Assessed by Tissue Doppler Imaging as a New Predictor of Cardiac Events After Patrick M. Burns, Patrick Kearns, Pedro Vargas-Pinto, Yoshinori Non-ST-Elevation Acute Coronary Syndrome Nishijima, Yu Ding, Mihaela Jekic, Tam Tran, Jiarui Lian, Kun Huang, Orlando P. Simonetti, Jay L. Zweier, The Ohio State University, Yong-Tai Liu, Rui-Jie Li, Qing Zhang, Gabriel WK Yip, Bryan P. Yan, Columbus, OH Yat-Yin Lam, Alex PW Lee, Cheuk-Man Yu, The Chinese University of Hong Kong, Hong Kong, Hong Kong, West China Hospital, Sichuan Learning Objective: appreciate the acute changes in myocardial University, Chengdu, Sichuan, People’s Republic of China morphology and function during a myocardial infarction. Learning Objective: observe the predictive value of atrial function assessed by tissue Doppler imaging. 1157-291 Mitochondrial Depolarization Is Not Responsible for Cardioprotection During Ischemic Preconditioning

1156-286 Determinants of Major Bleeding Complications Daniel S. Lee, Ricardo Quarrie, Gregory Steinbaugh, Douglas and its Impact on Hospital Outcome in NSTE-ACS Pfeiffer, Jay Zweier, Juan Crestanello, The Ohio State University in Clinical Practice: Lessons From The Euro Heart Medical Center, Columbus, OH Survey ACS Registry Learning Objective: understand that mito membrane depolarization Anselm K. Gitt, Frank Towae, Ralf Zahn, Marek Gierlotka, Hugo is not responsible for the cardioprotective effect IPC Katus, Wojtek Wojakowski, Michal Tendera, Jean-Pierre Bassand, Euro Heart Survey ACS Registry, Institut f. Herzinfarktforschung 1157-292 Mast cell Could Regulate the Survival of Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany, Cardiomyocytes in a Myocardial Infarction Rat Herzzentrum Ludwigshafen, Ludwigshafen, Germany Model

Learning Objective: identify patients with high risk for bleeding Youngkeun Ahn, Jin Sook Kwon, Yong Sook Kim, Ae Sin Cho, Mun Hwa Hong, Myung Ho Jeong, Seung Uk Lee, Jeong Gwan Cho, Jong 1156-288 Validation Of The Crusade Bleeding Risk Score In Chun Park, Jung Chaee Kang, Department of Cardiology, Chonnam Patients With Non-st Elevation Acute Myocardial National University Hospital, Gwangju, South Korea, Gwangju Infarction In Spain Christian Hospital, Gwangju, South Korea Myocardial Ischemia

Rafael Vidal-Perez, Sr., Emad Abu-Assi, Sr., José María Garcia- Learning Objective: to elucidate the effects of mast cell in a and Infarction Acuña, Sr., Carlos Peña-Gil, Sr., Jose Ramón Gonzalez-Juanatey, myocardial infarction rat model. Sr, Cardiologiy Department. Clinico Universitario de Santiago de Compostela, Santiago de Compostela, Spain 1157-293 Downregulation of Cardiac Myoglobin May Limit the Cardioprotective Effects of Nitrite Therapy Following Learning Objective: Evaluate the performance of the CRUSADE Bleeding risk score in an independent cohort different from the Exercise original study Chad K. Nicholson, Juan Pablo Aragon, David Bennett Grinsfelder, Marah Elston, David J. Lefer, John W. Calvert, Emory University 1156-289 Hemoglobin Levels at Admission Add Prognostic School of Medicine, Atlanta, GA Value to the GRACE Score in Non-ST Elevation Acute Learning Objective: identify myoglobin as an important nitrite Coronary Syndromes reductase Luis Correia, Jamile Leal, Maria C. Almeida, Alexandre C. Souza, Ana P. Bittencourt, Rafael Freitas, J Péricles Esteves, Medical School 1157-294 Hypoxia Limits the Cardiac Regenerative Potential of Bahia, Salvador, Brazil, Portuguese Hospital, Salvador, Brazil of Hypoxia-Inducible- Factor-1alpha Transduced Learning Objective: identify whether hemoglobin should be Cardiac-Derived Stem Cells evaluated as part of prognostic assessment in pacientes with non- Michail Bonios, John Terrovitis, Connie Chang, Aurelio Pinheiro, ST elevation ACS James Engles, Andreas Barth, Pei Dong, Veronica Lea Dimaano, Miguel Aon, Inhwa Tina Lee, Christina Melexopoulou, Richard Wahl, Brian O’ Rourke, Theodore Abraham, Roselle Abraham, Johns Hopkins University, Baltimore, MD Learning Objective: evaluate the role of hypoxia inducible factor in the regenerative capacity of cardiac derived stem cells A116 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1158 NOVEL STRATEGIES TO LIMIT ISCHEMIC LV 1159 LIMITATION OF INFARCT SIZE DYSFUNCTION Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1 1159-302 Exogenous Reconstituted High-density lipoprotein 1158-296 The Generation and Storage of Nitric Oxide (rHDL) Attenuates The Myocardial Ischemic- Metabolites During Exercise Training Contributes to reperfusion Injury Exercise-Mediated Cardioprotection Eun-Ji Kim, Dong-Ju Choi, Min-Jung Park, In-Ho Chae, Goo Yeong John W. Calvert, Marah Elston, Amy Sindler, Susheel Gundewar, Cho, Tae-Jin Youn, Yung-Seok Cho, Jung-Won Suh, Ki-Yong Kim, David Bennett Grinsfelder, Juan Pablo Aragon, Douglas R. Seals, Seoul National University, Bundang Hospital, Seoungnam, South David J. Lefer, Emory University School of Medicine, Atlanta, GA Korea, Protein research Lab, CRC, Green Cross Corp., Youngin, South Korea Learning Objective: identify a role of nitrite in exercise-mediated cardioprotection Learning Objective: investigate the protective effect of rHDL on Ischemia/reperfusion Injury 1158-297 Hydrogen Sulfide Confers Cardioprotection in the Setting of Diabetes 1159-303 Intraaortic Balloon Pump Counterpulsation Augments the Benefits of Reperfusion on Left John W. Calvert, Susheel Gundewar, John Elrod, David J. Lefer, Ventricular Mechanoergetics - Experimental Study Emory University School of Medicine, Atlanta, GA Konstantinos Malliaras, Nikolaos Diakos, Iraklis Pozios, Eleni Learning Objective: identifyf a role for hydrogen sulfide in the Tseliou, Dimitrios Koudoumas, Lampros Katsaros, Michalis Bonios, treatment of myocardial ischemia in the setting of diabetes Stella Vakrou, Emmanouil Konstantakis, John Terrovitis, John N. Nanas, University of Athens, 3rd Cardiology Dept, Athens, Greece Extracardiac Injection of Plasmid VEGF Improves 1158-298 165 Myocardial Function by Stimulating Myocytes to Learning Objective: understand the role of IABP support on Re-enter the Cell Cycle in Swine with Hibernating myocardial systolic and diastolic function, during both acute ischemia and reperfusion Myocardium Mohamad Bourji, Gen Suzuki, Techung Lee, John M. Canty, Jr., 1159-304 Infusion of Glucagon-Like Peptide-1 Protects University at Buffalo, Buffalo, NY Against Ischemic Left Ventricular Dysfunction Learning Objective: Skeletal muscle injection of plasmid VEGF165 During Dobutamine Stress Echocardiography in stimulates cardiac repair in large animal model with chronically Patients with Coronary Artery Disease ischemic myocardium Philip Read, Fakhar Z. Khan, David P. Dutka, University of Cambridge, Cambridge, United Kingdom 1158-299 Effect of AT2 Receptor Deficiency as well as Pharmacological AT2 Receptor Stimulation on Learning Objective: understand that glucagon-like peptide-1 protects Myocardial Infarction-Associated Morbidity and the heart against ischemia during dobutamine stress Mortality 1159-305 The Stable Hydrogen Sulfide Donor, Diallyl Trisulfide, Ralf A. Benndorf, Martha Kirstein, Daniel Biermann, Michael Protects against Acute Myocardial Infarction in Mice Didié, Wolfram H. Zimmermann, Rainer H. Böger, Institute of Pharmacology, Toxicology, and Clinical Pharmacy, Technical Benjamin L. Predmore, D. Bennett Grinsfelder, Juan Pablo Aragon, and Infarction University of Braunschweig, Braunschweig, Germany Marah Elston, John W. Calvert, David J. Lefer, Emory University,

Myocardial Ischemia Atlanta, GA Learning Objective: At the conclusion of this presentation, participants will be able to describe the impact of the AT2 receptor Learning Objective: evaluate the use of the stable hydrogen sulfide on myocardial infarction-associated morbidity and mortality donor, DATS, in the treatment of MI/R injury.

The β1 Blocker/β3 Agonist Nebivolol Protects 1158-300 Sildenafil In Conjunction With Angiotensin- 1159-306 Converting Enzyme Inhibitor Is Effective In Limiting Against Acute Myocardial Infarction in Mice Infarct Expansion In A Porcine Model Of Anterior Juan Pablo Aragon, Sandeep Patel, Marah Elston, John W. Calvert, Myocardial Infarction David Bennett Grinsfelder, David J. Lefer, Emory University School of Medicine, Atlanta, GA Doo Sun Sim, Myung Ho Jeong, Yun Hyeon Kim, Song Choi, Hyun Kuk Kim, Sung Soo Kim, Jum Suk Ko, Min Goo Lee, Keun Ho Park, Learning Objective: identify the potential of nebivolol as a Hyun Ju Yoon, Nam Sik Yoon, Young Joon Hong, Hyung Wook Park, cardioprotective agent Ju Han Kim, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang, Chonnam National University Hospital, Gwangju, South Korea Learning Objective: understand the benefits of sildenafil in patients with acute myocardial infarction, especially those with erectile dysfunction. JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A117

1160 OPTIMIZING STEM CELL THERAPY 1160-311 Enhanced Therapeutic Effects of Mesenchymal Stem Cells on Myocardial Infarction by Ischemic Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Postconditioning in Rats Georgia World Congress Center, Hall B5 Jun Fang, Lianglong Chen, Lin Fan, Liming Wu, Xiangqi Chen, Weiwei Presentation Hour: 9:30 a.m. - 10:30 a.m. Li, Yunlin Lin, Weiwei wang, Department of Cardiology, Union CME/CE Hours: 1 Hospital, Fujian Medical University, Fuzhou, People’s Republic of China 1160-307 Improvement of Biodistribution in Cardiac Stem Cell Therapy Using Fibrinogen Learning Objective: demonstrate that ischemic postconditioning can promote the survival of engrafted stem cells and enhance their Andreas Martens, Sebastian V. Rojas, Robert Zweigerdt, Christian benefits to myocardial infarction by endogenously modifying host Rathert, Ulrich Martin, Axel Haverich, Ingo Kutschka, Clinic for micro-environment Cardiac, Thoracic, Transplantation and Vascular Surgery; Hannover Medical School, Hannover, Germany, Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, 1161 MYOCARDIAL ISCHEMIA/INFARCTION: Hannover, Germany ANIMAL MODELS Learning Objective: demonstrate the advantage of using fibrinogen Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. as carrier for intracardiac stem cell delivery in terms of cell Georgia World Congress Center, Hall B5 retention. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1160-308 Oxytocin; A Priming Reagent to Commit UCB-MSCs for Cardiac Repair -Function study and Phase A Reliable Porcine Coronary Model Of Chronic Total Retardation Imaging Technique of Oxytocin-Treated 1161-313 Occlusion Using Copper Stents UCB-MSC Doo Sun Sim, Myung Ho Jeong, Young Joon Hong, Youngkeun Ahn, Youngkeun Ahn, Yong Sook Kim, Ae Shin Jo, Mun Hwa Hong, Jin Robert S. Schwartz, Jung Chaee Kang, Chonnam National University Sook Kwon, Sang Mo Shin, Myung Ho Jeong, Jeong Gwan Cho, Jong Hospital, Gwangju, South Korea Chun Park, Jung Chaee Kang, Department of Cardiology, Chonnam National University Hospital, Gwangju, South Korea, Heart Research Learning Objective: find this animal model of chronic total occlusion Center of Chonnam National University Hospital, Gwangju, South useful in developing new interventional devices Korea Learning Objective: to evaluate the effect of oxytocin on umbilical 1161-314 Trans-Iliac Rat Aorta Stenting Model: A Novel High cord blood derived mesenchymal stem cells Throughput Preclinical Stent Model for Restenosis and Thrombosis

1160-309 Endothelial Progenitor Cell Transplantation Shizu Oyamada, Xiaodong Ma, Tim Wu, Michael P. Robich, Cesario Decreases Lymphangiogenesis and Adverse Bianchi, Frank W. Sellke, Roger J. Laham, Beth Israel Deaconess Ventricular Remodeling In A Mouse Model Of Acute Medical Center, Boston, MA, VasoTech, Inc., Lowell, MA Myocardial Infarction Learning Objective: describe that human-sized stents can be Jae-Hyeong Park, Jung Yeon Yoon, Sun Mi Koh, Jun Hyung Kim, Jae- successfully implanted into the rat aorta via iliac artery insertion Myocardial Ischemia

Hwan Lee, Si Wan Choi, In-Whan Seong, Jin-Ok Jeong, Department with good survival and Infarction of internal medicine, Chungnam national university, Daejeon, South Korea 1161-315 Lack of Effect of the Stretch-Activated Channel Learning Objective: EPC transplantation demonstrated decreased Blocker GsMtx4 on Ventricular Arrhythmias lymphangiogenesis and favorable ventricular remodeling after MI Following Coronary Occlusion in Swine Jose A. Barrabes, Luis Agulló, Javier Inserte, M Ángeles García, 1160-310 Presence of Endothelial Colony-Forming Cells at David Garcia-Dorado, Hospital Universitari Vall d’Hebron, Barcelona, Admission is Associated With a Reduction in Infarct Spain Size at 6 Months Follow-up: A Magnetic Resonance Learning Objective: Interpret the effect of the SAC blocker GsMtx4 Imaging Study in Patients With Acute Myocardial on ischemic ventricular arrhythmias Infarction

Nicolas F. Meneveau, Frederic Deschaseaux, Marie-France Seronde, 1161-317 Percutaneous Induced Left Ventricle Myocardial Vincent Descotes-Genon, Francois Schiele, David Chalmers, Pierre Infarction with Re-open LAD in a Clinical Relevant Tiberghien, Jean-Pierre Bassand, Jean-Pierre Kantelip, Siamak Animal Model Davani, University Hospital Jean Minjoz, Besancon, France, INSERM U645, Etablissement Français du Sang Bourgogne Franche-Comté, Jin-Shen Li, Xinhua Yin, Nakamura Takamitsu, Pendyala K. Besancon, France Lakshmana, Irena Brants, Stephen Frohwein, Jack P. Chen, Nicolas Chronos, Robert Matheny, Dongming Hou, Saint Joseph’s Learning Objective: Describe the relationship between initial ECFC Translational Research Institute/Saint Joseph’s Hospital of Atlanta, colony levels and changes in infarct size at 6 months Atlanta, GA, CorMatrix Cardiovascular Inc., Atlanta, GA Learning Objective: demonstrate MI function in pig free LV A118 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1162 RISK PREDICTION IN MYOCARDIAL ISCHEMIA/ 1208 EVOLUTION OF TROPONIN TESTING IN ACUTE INFARCTION CORONARY SYNDROMES Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1

1162-319 Psoriasis is a Risk Factor for Myocardial Infarction 1208-256 Interpreting New High Sensitive Troponin I And T and Percutaneous Coronary Intervention: A Danish Assays In The Setting Of Chronic Kidney Disease Nationwide Cohort Study Christopher R. DeFilippi, Robert Christenson, Sue Henderson, Show- Ole Ahlehoff, Gunnar H. Gislason, Jesper Lindhardsen, Casper Hong Duh, James Januzzi, University of Maryland, Baltimore, MD, H. Jorgensen, Mette G. Charlot, Steen Z. Abildstrom, Lone Skov, Massachusetts General Hospital, Boston, MA Christian Torp-Pedersen, Peter R. Hansen, Department of Cardiology, Learning Objective: Evaluate potential confounders to intepretation Copenhagen University Hospital Gentofte, Hellerup, Denmark of new high senstive troponin assays in patients with chronic kidney Learning Objective: Identify psoriasis as a risk factor for disease cardiovascular disease 1208-257 High Sensitivity Troponin Assay for Early Diagnosis 1162-320 Uric Acid Level is a Predictor of Coronary Collateral of Acute Coronary Syndrome in a Real-World Development in Patients with Non ST Segment Situation: Comparison Between hs-TnT, LOCI hs-TnI, Elevation Acute Coronary Syndrome hs-TnI Roche and Conventional TnT.

MEHMET KAYA, AHMET KASAPKARA, BAHADIR SARLI, ALI DOGAN, Gina Biasillo, Luigi M. Biasucci, Roberta Della Bona, Ilaria Dato, TUGRUL INANC, MUSTAFA DURAN, ABDURRAHMAN OGUZHAN, Milena Leo, Massimo Gustapane, Maria T. Cardillo, Antonella RAMAZAN TOPSAKAL, ERCIYES UNIVERSITY, KAYSERI, Turkey Stefanelli, Pio Cialdella, Andrea Silenzi, Giulia Pignataro, Niccolò Gentiloni Silveri, Martina Zaninotto, Mario Plebani, Filippo Crea, Learning Objective: Coronary collateral development is poor in Catholic University of Sacred Heart, Rome, Italy, Hospital University, patients with high levels of uric acid. Uric acid level is an indicator Padua, Italy of coronary collateral development. Learning Objective: evaluate patients with chest pain 1162-321 Measurement of Circulating Pregnancy-Associated Plasma Protein A (cPAPP-A) Identifies Patients with 1208-259 High Sensitive Troponin T Rules Out Myocardial Acute Coronary Syndromes Infarction 2 Hours From Admission In Chest Pain Patients. Maha A. Al-Mohaissen, John Hill, Claire Heslop, Andrew Ignaszewski, Jiri Frohlich, University of British Columbia, Vancouver, BC, Canada, Dina Melki, Suzanne Lind, Stefan Agewall, Tomas Jernberg, St Paul’s Hospital, Vancouver, BC, Canada Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Aker University Hospital and Oslo University, Oslo, Norway Learning Objective: evaluate the diagnostic ability of cPAPP-A, which may be of help in the evaluation of unstable plaques and the Learning Objective: Demonstrate that New high sensitive troponin identification of patients preseting with acute coronary syndromes. assays will improve the early diagnostic assessment of chest pain patients 1162-322 Plasma and Tissue Metabolomic Profiling in a Porcine Ischemia-Reperfusion Model Reveals Novel 1208-260 Impact of Troponin Elevation on Outcomes of Early Markers of Myocardial Injury Patients with Acute Coronary Syndromes and Chronic Renal Insufficiency and Infarction Renato Lopes, E. Marc Jolicoeur, Svati H. Shah, Mark Y. Chan,

Myocardial Ischemia Tracy Y. Wang, Robert D. Stevens, Brett R. Wenner, Olga R. Ilkayeva, Subasit Acharji, Eugenia Nikolsky, Giora Weisz, George Dangas, James R. Bain, Jean-Francois Tanguay, Christopher B. Newgard, L. Fredrick Feit, Steven Manoukian, Alexandra J. Lansky, Roxana Kristin Newby, Duke Clinical Research Institute, Duke University Mehran, Gregg W. Stone, Cardiovascular Research Foundation, New Medical Center, Durham, NC York, NY, Columbia University Medical Center, New York, NY Learning Objective: Examine plasma and tissue metabolomic Learning Objective: Evaluate outcomes of troponin elevation in CRI profiles in an ischemic-reperfusion animal model patients presenting with ACS

1162-323 CK-MB Has Prognostic Value Independent of 1208-261 Characteristics of Chest Pain Patients Without Troponins in Non ST-Elevation ACS Population. Acute Coronary Syndromes Stratified by a “Hyper- sensitive” Troponin I Assay Nicholas Kalayeh, Ramil Goel, Madhavagopal Cherukuri, Akil I. Loli, Kenneth B. Desser, Banner Good Samaritan Medical Center, Christopher R. DeFilippi, Puneet Gandotra, Mary Lou Gantzer, Sue Phoenix, AZ, Phoenix VA Health Care System, Phoenix, AZ Henderson, Jill Heckendorf, Robert Christenson, University of Maryland, Baltimore, MD Learning Objective: Patients with elevated CK-MB had higher mortality regardless of troponin status. Learning Objective: Identify the signficance of an elevated hsTnI level in the absence of an acute corornary syndrome JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A119

1208-262 Comparison of the Prognostic Value of Peak CK-MB 1209-268 Increased Admission Glucose Relates with and Troponin Levels among Patients with Acute Increased 5-Year Mortality in Myocardial Infarction Myocardial Infarction Patients, Irrespective of the Initially Applied Reperfusion Strategy Chee Tang Chin, Tracy Y. Wang, Shuang Li, Eric D. Peterson, Stephen D. Wiviott, James A. deLemos, Michael C. Kontos, Matthew T. Roe, Maarten de Mulder, Jan Hein Cornel, Tjeerd van der Ploeg, Victor Duke Clinical Research Institute, Durham, NC A. Umans, Eric Boersma, Medical Center Alkmaar, Alkmaar, The Netherlands, Erasmus University Medical Center, Rotterdam, The Learning Objective: Compare prognostic implications of peak Netherlands biomarkers in acute myocardial infarction Learning Objective: recognize that elevated admission glucose remains a predictor of mortality in spite of advances that have been 1209 DIABETES, RENAL INSUFFICIENCY AND OTHER made in reperfusion with e.g. primary PCI HIGH-RISK CO-MORBIDITIES Differential Impact of Renal Dysfunction on Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. 1209-269 Mortality Following First Acute Myocardial Infarction Georgia World Congress Center, Hall B5 in Nonelderly and Elderly Patients Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 Masami Kosuge, Kazuo Kimura, Sunao Kojima, Hisao Ogawa, the Japanese Acute Coronary Syndrome Study (JACSS)Investigators, Yokohama City University Medical Center, Yokohama, Japan, 1209-265 Renal Insufficiency in Patients with a Total Occlusion of a Coronary Artery after Myocardial Kumamoto University, Kumamoto, Japan Infarction Learning Objective: Evaluate the association between renal dysfunction and in-hospital mortality following acute myocardial Judith S. Hochman, Ramin Hastings, Harmony R. Reynolds, Vladimir infarction in nonelderly and elderly patients Dzavik, Dimitris Mikas, Lampros K. Michalis, Francois Schiele, Sandra A. Forman, Gervasio A Lamas A. Lamas, New York University Additional Prognostic Value of Suspected School of Medicine, New York, NY 1209-271 Obstructive Sleep Apnea in Individuals with Non-ST Learning Objective: Describe outcomes and safety for subjects Elevation Acute Coronary Syndromes with renal insufficiency presenting with late total occlusion after MI randomized to PCI or medical therapy. Luis Correia, Alexandre C. Souza, Jamile Leal, Maria C. Almeida, Rafael Freitas, Ana P. Bittencourt, J Péricles Esteves, Medical School of Bahia, Salvador, Brazil, Portuguese Hospital, Salvador, Brazil 1209-266 Impact of Impaired Renal Function on Acute Treatment and Hospital Mortality of NSTE-ACS in Learning Objective: Know whether OSA should be assessed as a Clinical Practice in Europe: Lessons From the Euro potential prognostic factor during ACS Heart Survey ACS Registry 1209-272 Effect of Postprandial Hyperglycemia on Clinical Anselm K. Gitt, Ralf Zahn, Frank Towae, Hugo Katus, Alexander Outcomes in Nondiabetic Patients with Stable Pakhomenko, Francois Schiele, Jean-Pierre Bassand, Euro Heart Angina Survey ACS Registry, Institut f. Herzinfarktforschung Ludwigshafen,

University of Heidelberg, Ludwigshafen, Germany, Herzzentrum Shoichi Kuramitsu, Hiroyoshi Yokoi, Takenori Domei, Kyohei Yamaji, Myocardial Ischemia Ludwigshafen, Ludwigshafen, Germany

Yoshimitsu Soga, Takeshi Arita, Shinichi Shirai, Kenji Ando, Koyu and Infarction Learning Objective: identify patients with NSTE-ACS at high risk Sakai, Masashi Iwabuchi, Hideyuki Nosaka, Masakiyo Nobuyoshi, Kokura Memorial Hospital, Kitakyushu, Japan 1209-267 The Contribution of Renal Failure and Diabetes Learning Objective: interpret the postprandial hyperglycemia as an Mellitus to the Prognosis of Patients with Acute independent predictor of clinical outcomes in nondiabetic patients Myocardial Infarction Undergoing Percutaneous with stable angina. Coronary Intervention

Manuel A. Gonzalez, Sara D. Collins, Itsik Ben-Dor, Gabriel Maluenda, Asmir I. Syed, Michael A. Gaglia, Jr., Zhenyi Xue, Cedric Delhaye, Kohei Wakabayashi, Nicholas N. Hanna, Rebecca Torguson, William O. Suddath, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard, Lowell F. Satler, Ron Waksman, Washington Hospital Center, Washington, DC Learning Objective: recognize the worse prognosis of acute myocardial infarction patients having a combination of renal failure and diabetes A120 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1211 SEX DIFFERENCES IN EVALUATION, TREATMENT 1211-288 Sex Differences in Presentation without Chest Pain AND OUTCOMES IN PATIENTS WITH ACUTE for Confirmed Myocardial Infarction Are Attenuated with Advancing Age in the National Registry of CORONARY SYNDROMES Myocardial Infarction (NRMI) Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. John G. Canto, William J. Rogers, Robert J. Goldberg, Eric D. Georgia World Congress Center, Hall B5 Peterson, Nanette K. Wenger, Viola Vaccarino, Catarina I. Kiefe, Paul Presentation Hour: 3:30 p.m. - 4:30 p.m. Frederick, George Sopko, Z. J. Zheng, For the NRMI Investigators, CME/CE Hours: 1 Watson Clinic, Lakeland, FL, National Heart, Lung, and Blood Institute, Bethesda, MD 1211-282 Gender Differences in Adjunctive Treatment and Learning Objective: Understand relationship of age and sex on Hospital Outcome of NSTE-ACS Patients Undergoing symptom presentation after MI PCI In Clinical Practice In Europe: Lessons From The Euro Heart Survey PCI Registry 1211-289 Frequency of Coronary Angiography and Anselm K. Gitt, Timm Bauer, Uwe Zeymer, Ralf Zahn, Franz Revascularization among Men and Women with Weidinger, Ricardo Seabra-Gomes, Jean Marco, Euro Heart Survey Myocardial Infarction and their Relationship to PCI Registry, Institut f. Herzinfarktforschung Ludwigshafen, Mortality at One Year: An Analysis of the Geisinger University of Heidelberg, Ludwigshafen, Germany, Herzzentrum Myocardial Infarction Cohort Ludwigshafen, Ludwigshafen, Germany Kimberly A. Skelding, Peter B. Berger, James C. Blankenship, Vernon Learning Objective: evaluate the impact of female gender on H. Mascarenhas, Christopher W. Good, Thomas D. Scott, John M. treatment of NSTE-ACS Hodgson, Geisinger Medical Center, Danville, PA Learning Objective: Identify sex bias in the selection of strategies to Underutilization Influencing Factors of Evidence 1211-283 evaluate patients with myocardial infarction (MI), and if the choice Based Therapies in Women of strategy influenced survival. Raffaele Bugiardini, Andrew T. Yan, Raymond T. Yan, David Fitchett, Anatoly Langer, Shaun G. Goodman, Olivia Manfrini, on the behalf 1212 NOVEL EMERGING THERAPIES FOR CHRONIC of the Canadian Acute Coronary Syndrome Registry I and II Investigators, University of Bologna, Bologna, Italy, University of ISCHEMIC SYNDROME Toronto, Toronto, ON, Canada Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Learning Objective: interpret the reasons of gender related Georgia World Congress Center, Hall B5 treatment disparities Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1211-284 Gender-Associated Difference in Pre-Hospital Evaluation in Acute Coronary Syndromes 1212-290 Echo-Guided Extracorporeal Shock Wave Therapy Johanna P. Contreras, TUFTS MEDICAL CENTER, BOSTON, MA for Refractory Angina Improves Regional Myocardial Blood Flow as Assessed by PET Imaging Learning Objective: Demonstrated the presence of gender disparities in acute coronary syndrome Lothar Faber, Oliver Lindner, Christian Prinz, Eva Fricke, Detlef Hering, Wolfgang Burchert, Dieter Horstkotte, Department of 1211-285 Contemporary Outcomes of Primary Percutaneous Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr Coronary Intervention in Men and Women for Acute University Bochum, Bad Oeynhausen, Germany, Inst Radiol, Nucl ST-Segment Elevation Myocardial Infarction: Does Med, Mol Imag, Heart and Diabetes Center NRW, Ruhr University Gender Still Matter? Bochum, Bad Oeynhausen, Germany

and Infarction Learning Objective: identify patients who might benefit from M. Fuad Jan, Abdul-Moiz Hafiz, Naoyo Mori, Angela Schlemm, noninvasive therapies for refractory angina Myocardial Ischemia Anthony C. DeFranco, Anjan Gupta, Tanvir Bajwa, Suhail Allaqaband, Aurora Cardiovasc Srvs, Aurora Sinai/St. Luke’s Med Ctrs, Univ Wisconsin Sch Med & Public Health-MCC, Milwaukee, WI, Center 1212-291 Treatment with Whole Body Periodic Acceleration for Urban Population Health, University of Wisconsin-Milwaukee, with a Horizontal Motion Platform Reverses Left Milwaukee, WI Ventricular Remodeling in Angina Patients with Old Myocardial Infarction Learning Objective: identify the immediate outcomes of percutaneous intervention in men and women after acute STEMI Shoichi Miyamoto, Moriaki Inoko, Tetsuya Haruna, Muneo Oba, Yoshiaki Saji, Eisaku Nakane, Tomomi Abe, Ken-ichi Sasaki, Hidehiro 1211-286 Sex Differences in High-Risk Acute Coronary Itoh, Terunobu Fukuda, Junji Nakashima, Nozomi Tanaka, Koji Syndromes: Insights from EARLY-ACS Ueyama, Ryuji Nohara, Masatoshi Fujita, Cardiovascular Center, Kitano Hospital, Tadukekofukai Medical Research Institute, Osaka, Jean-François Tanguay, L Kristin Newby, Judith Hochman, Cynthia M. Japan, Human Health Sciences, Kyoto University Graduate School of Westerhout, Robert M. Califf, C Michael Gibson, Robert P. Giugliano, Medicine, Kyoto, Japan Robert A. Harrington, Frans Van de Werf, Paul W. Armstrong, Montreal Heart Institute, Montreal, QC, Canada Learning Objective: evaluate the improvement of exercise capacity, LV function and myocardial ischemia through central and peripheral Learning Objective: To understand the role of gender in ACS effects by using whole body periodic acceleration presentation and outcome. JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A121

1212-292 Physiologic Evaluation Of Myocardial Bridging-A 1213-299 Medical Management Of Stable Coronary Artery New Analysis For An Old Disease Disease Before And After Elective PCI

Kyungil Park, Kyung Woo Park, Hae-Young Lee, Hyun-Jae Kang, Bon- Amer Ardati, Mauro Moscucci, Dean Smith, Stanley Chetcuti, Kwon Koo, Hyo-Soo Kim, Byung-Hee Oh, Young-Bae Park, Division P. Michael Grossman, Hitinder Gurm, University of Michigan of Cardiology, Department of Internal Medicine, Seoul National Cardiovascular Center, Ann Arbor, MI University Hospital, Seoul, South Korea Learning Objective: Describe the use of medical therapy in patients Learning Objective: evaluate severity of myocardial bridging receiving PCI for stable CAD

1212-293 Long-term Clinical Course of Patients with Isolated 1213-300 Impact of Ranolazine on Revascularization and Myocardial Bridge Healthcare Costs Among Angina Patients

SungSoo Kim, Myung Ho Jeong, Hyun Kuk Kim, Min Chul Kim, Kyung Charles E. Phelps, Erin Buysman, Gabriel Gomez Rey, Matt Hun Cho, Min Goo Lee, Jeom Seok Ko, Keun Ho Park, Doo Sun Sim, Cheung, Noreen Henig, Francois Everhard, University of Rochester, Nam Sik Yoon, Hyun Ju Yoon, Hyun Yuk Park, Ju Han Kim, Young Rochester, NY Joon Hong, Young Keun Ahn, Jung Kwan Cho, Jong chun Park, Jung Learning Objective: Understand the impact of ranolazine, a novel Chaee Kang, Chonnam National University, Gwang Ju, South Korea antianginal treatment, on risk of revascularization and healthcare Learning Objective: identify that myocardial bridge is not benign and costs and recurrent hospitalization is common.

1214 STABLE ISCHEMIC SYNDROME--INTERVENTIONAL 1212-294 Trends of Enhanced External Counterpulsation Therapy in the US: Reimbursement Shapes the Use STRATEGIES but Not the Outcome Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. William E. Lawson, John CK Hui, Elizabeth D. Kennard, Gregory W. Georgia World Congress Center, Hall B5 Barsness, IEPR Investigators, Stony Brook University Hospital, Stony Presentation Hour: 3:30 p.m. - 4:30 p.m. Brook, NY, University of Pittsburgh, Pittsburgh, PA CME/CE Hours: 1 Learning Objective: Identify appropriate patients for treatment with EECP 1214-302 SPIRIT II Study: Evaluation of the XIENCE V Everolimus Eluting Coronary Stent in the Treatment of Patients with de novo Native Coronary Artery 1213 STABLE ISCHEMIC SYNDROME--MEDICAL Lesions COTHERAPIES FOR SECONDARY PREVENTION Yoshinobu Onuma, Patrick W. Serruys, the SPIRIT II Investigators, Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Thorax Center, Erasmus MC, Rotterdam, The Netherlands Georgia World Congress Center, Hall B5 Learning Objective: demonstrate long-term outcome after Presentation Hour: 3:30 p.m. - 4:30 p.m. everolimus-eluting stent implantation CME/CE Hours: 1 1214-303 Percutaneous Coronary Intervention versus Medical 1213-296 Statins Moderate Coronary Atheroma but not Therapy in Stable Coronary Artery Disease: A Meta- Myocardial Ischemia Coronary Calcification: Results from Meta-Analyses analysis and Infarction

Michael Henein, Andrew Owen, Public Health, Umea, Sweden Pawan Patel, Mukesh Singh, Dipal Patel, Janos Molnar, Rohit R. Learning Objective: distinguish between the response of atheroma Arora, Rosalind Franklin University of Medicine and Science/Chicago and calcification to statins therapy Medical School, North Chicago, IL Learning Objective: Evaluate role medical therapy and PCI in stable 1213-297 Long-Term Beta-Blocker Use Is Associated With coronary artery disease Increased Risk of Myocardial Infarction Among Cocaine Users 1214-304 Mechanism of Side Branch Jailing in Bifurcation Lesion: Plaque or Carina Shift? Avinash Singavarapu, Ronald Zolty, Montefiore Medical Center, Bronx, NY Ji-Hyun Kim, Bon-Kwon Koo, Myung-Ki Seo, Seung-Jung Park, Kyung Woo Park, Hye-Young Lee, Hyun-Jae Kang, Hyo-Soo Kim, Byung-Hee Learning Objective: Evaluate the interaction between beta-blockers Oh, Young-Bae Park, Chang-Wook Nam, Seung-Ho Hur, Donghoon and cocaine among users with heart disease Choi, Yangsoo Jang, Joo-Yong Hahn, Hyeon-Cheol Gwon, Myeong-Ho Yoon, Seung-Jea Tahk, Woo-Young Chung, Young-Seok Cho, Dong- Ivabradine Reduces Angina Pectoris in Patients 1213-298 Ju Choi, Sung Jin Oh, Yasuhiro Honda, Peter J. Fitzgerald, William After PCI: Results From the REDUCTION-Study F. Fearon, Seoul National University hospital, Seoul, South Korea, Ralf Koester, Jan Kaehler, Thomas Meinertz, for the REDUCTION Stanford University Medical center, Stanford, CA Study Investigators, University of Hamburg Heart Center, Hamburg, Learning Objective: understand and interpret the mechanism of side Germany branch luminal narrowing after main branch stent implantation. Learning Objective: Demonstrates that ivabradine offers additional benefit in patients with ongoing angina pectoris despite PCI A122 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1214-305 Clinical Outcomes Associated with Off-Label Use of 1215-310 The Outcome of Primary Percutaneous Coronary Sirolimus- versus Paclitaxel-Eluting Stents Intervention for Stent Thrombosis Causing ST Elevation Myocardial Infarction Myong Hwa Yamamoto, Masahiko Ochiai, Kazuhiro Ashida, Tadayuki Yakushiji, Kennosuke Yamashita, Shigeo Saito, Koichi Hoshimoto, Mehmet Ergelen, Sevket Gorgulu, Huseyin Uyarel, Tugrul Norgaz, Yuki Mikoshiba, Naoei Isomura, Hiroshi Araki, Chiaki Obara, Showa Huseyin Aksu, Erkan Ayhan, Zeki Y. Gunaydın, Turgay Isık, Gokhan University Northern Yokohama Hospital, Yokohama, Japan Cicek, Tuna Tezel, Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey, Learning Objective: interpret clinical outcomes associated with off- Department of Cardiology, Balıkesir University, School of Medicine, label use of sirolimus- versus paclitaxel-eluting stents. Balıkesir, Turkey 1214-306 The Risk Factors and Characters for Progressing Learning Objective: primary PCI for treatment of ST is less effective, New Lesions in the Patients Undergoing PCI and these patients are

Atsuko Nakayama, Hiroyuki Morita, Hiroshi Iwata, Yasushi Imai, 1215-311 Prognosis of Totally Occluded Infarct Related Artery Takahide Kohro, Jiro Andoh, Tsutomu Yamazaki, Ryozo Nagai, Can be Worse than Non-totally Occluded Infarct Department of cardiology, University of Tokyo, Tokyo, Japan Related Artery in Asian Patients with Acute Non-ST Learning Objective: evaluate the risk factors of new lesion formation Elevation Myocardial Infarction? after CAG Sureshkumar Ramasamy, Seung-Woon Rha, Kanhaiya L Poddar, Ji Young Park, Lin Wang, Byoung Geol Choi, Myung Ho Jeong, Ji Bak 1215 MYOCARDIAL ISCHEMIA/INFARCTION: Kim, Seung Yong Shin, Un-Jung Choi, Cheol Ung Choi, Hong Euy Lim, IMPLICATIONS OF STENTS Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, KAMIR Investigators, Korea University Guro Hospital, Seoul, Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. South Korea, Chonnam National University Research Institute of Georgia World Congress Center, Hall B5 Medical Science, Gwangju, South Korea Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: identify high risk cases in NSTEMI CME/CE Hours: 1

MYOCARDIAL ISCHEMIA/INFARCTION: 1215-307 In Vivo Biocompatibility Comparison Between 1216 Novel Biodegradable Polymer and Existing Non- BIOMARKER IMPLICATIONS Biodegradable Polymer Coated Stents Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Shizu Oyamada, Xiaodong Ma, Tim Wu, Michael P. Robich, Cesario Georgia World Congress Center, Hall B5 Bianchi, Frank W. Sellke, Roger J. Laham, Beth Israel Deaconess Presentation Hour: 3:30 p.m. - 4:30 p.m. Medical Center, Boston, MA, VasoTech, Inc., Lowell, MA CME/CE Hours: 1 Learning Objective: demonstrate a novel PLGA/ACP copolymer has better biocompatibility than an existing non-biodegradable polymer 1216-313 The Relationship Between Glomerular Filtration Rate, Plasma Asymmetric Dimethylarginine (ADMA) 1215-308 Is Stent Fracture Still a Problem in the Era of the Level and Development of Coronary Collateral Second-generation Drug-eluting Stent? Circulation

SukMin Seo, Kiyuk Chang, Mahnwon Park, Eunho Choo, Jihee kim, Murat Çelik, Atila Iyisoy, Turgay Celik, Mahmut Ilker Yilmaz, Halil Yoonseok Koh, Woobaek Chung, Minseok Choi, Sunggyu Yoon, Yaman, Ersoy Isik, Gulhane Military Medical Academy, School of Hunjun Park, Hunjun Park, Hunjun Park, Hunjun Park, Hunjun Park, Medicine, Department of Cardiology, Ankara, Turkey Hunjun Park, Wooksung Chung, Wooksung Chung, Kibae Seung, Seoul St. Mary’s hospital, Seoul, South Korea Learning Objective: To elucidate the pathophysiological patways

and Infarction which could cause poor coronary collateral development in patients

Myocardial Ischemia with renal failure. 1215-309 Drug-eluting versus Bare-metal Stents in Treatment of Diabetic Patients with Acute Coronary 1216-314 Extracorporeal CRP-Apheresis after Myocardial Syndromes: Analysis from the Randomized ACUITY Infarction decreases Infarction Size and Preserves Trial Left Ventricular Ejection Fraction in Pigs

Karthik K. Challa, Eugenia Nikolsky, Roxana Mehran, Alexandra J. Timo Jerichow, Birgit Vogt, Dörte Mans, Frank Gebauer, Hassan Lansky, George D. Dangas, Adriano Caixeta, Brent T. McLaurin, David Abdel-Aty, Anna Christine Slagman, Malte Schröder, Christopher A. Cox, Jeffrey W. Moses, Frederick Feit, Monica Embacher, Gregg W. Bock, Gunnar Janelt, Sascha Ott, Franziska Wohlgemuth, Gülcan Stone, Cardiovascular Research Foundation, Manhattan, NY Yapici, Astrid Puppe, Jeanette Schulz-Menger, Diethelm Modersohn, Ralf Schindler, Ahmed Sheriff, Martin Möckel, Department Learning Objective: identify the early and long-term outcomes of of Cardiology, Charité-Universitätsmedizin, Berlin, Germany, using bare-metal stents vs drug-eluting stents in treating diabetes Department of Nephrology and Intensive Care Medicine, Charité- mellitus patients presenting with acute coronary syndrome Universitätsmedizin, Berlin, Germany Learning Objective: Interpret the role of C-reactive protein (CRP) in the pathophysiology of reperfusion damage after myocardial infarction and identify a new way to reduce infarction size by extracorporeal CRP-apheresis JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A123

1216-315 Galectin-1, A Galactoside Binding Lectin With 1217-321 Atorvastatin Rapidly Modifies Vascular Redox and Immunomodulatory Effects, Is Upregulated In The Increases Nitric Oxide Bioavailability In Human Mouse Heart During Acute Myocardial Infarction Arteries

Ignacio M. Seropian, Stefano Toldo, Diego O. Croci, Antonio Abbate, Charalambos A. Antoniades, Andreas Paschalis, Dimitris Gabriel A. Rabinovich, Benjamin W. Van Tassell, VCU School of Tousoulis, Constantinos Bakogiannis, Michael Dimosthenous, Pharmacy and VCU Pauley Heart Center, Richmond, VA, Laboratorio Alexis S. Antonopoulos, Costas Psarros, Nikolaos Sfyras, Dimitris de Inmunopatología, Instituto de Biología y Medicina Experimental, Lymperiadis, Kyriakoula Marinou, Keith M. Channon, Christodoulos Buenos Aires, Argentina Stefanadis, 1st Cardiology Department Hippokration Hospital, Athens, Greece, University of Oxford, Oxford, United Kingdom Learning Objective: Describe cardiac Galectin-1 expression after AMI Learning Objective: Understand statins direct effects on vacular 1216-316 Candesartan Suppresses Increase in Secreted redox state in patients with coronary atherosclerosis Frizzled Related Protein 2 and Fibrosis During Healing after Reperfused Myocardial Infarction in 1217-322 Anti-ischemic Efficacy Of Ivabradine In Combination the Rat Model With Bisoprolol Versus Uptitration Of Bisoprolol

Bodh I. Jugdutt, Ariv Palaniyappan, Halliday Idikio, University of Ekaterina N. Amosova, E. Andrejev, I. Zadereij, National Medical Alberta, Edmonton, AB, Canada University, Kiev, Ukraine Learning Objective: Demonstrate the effect of an AT1 receptor on Learning Objective: Identify new strategy of the antianginal therapy sFRP2 during healing after reperfused myocardial infarction in rats 1217-323 Ivabradine for the Treatment of Stable Angina 1216-317 High HDL Cholesterol Levels and Markers of Pectoris in Octogenarian Patients Inflammation and Metabolic Health in Patients Ralf Koester, Jan Kaehler, Thomas Meinertz, for the REDUCTION Hospitalized With Acute Myocardial Infarction Study Investigators, University of Hamburg Heart Center, Hamburg, Mikhail Kosiborod, John A. Spertus, Phillip G. Jones, Paul A. Germany Heidenreich, Krishnaji R. Kulkarni, Sergio Fazio, Mid America Heart Learning Objective: Demonstrates efficacy and safety of ivabradine Institute of Saint-Luke’s Hospital, Kansas City, MO in the treatment of octogenarians without relevant symptomatic Learning Objective: Describe the relationship between HDL levels bradycardia and the markers of inflammation and glucose metabolism 1263 STABLE ISCHEMIC SYNDROMES--BIOMARKERS 1217 STABLE ISCHEMIC SYNDROME--MYOCARDIAL AND OUTCOMES PROTECTION Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1 1263-256 Neopterin Predicts Left Ventricular Remodeling Myocardial Ischemia 1217-319 Myocardial Protection by Intracoronary in Patients with ST-segment Elevation Myocardial and Infarction Administration of Short-acting Beta-Blocker, Infarction Undergoing Primary Percutaneous Landiolol, during Elective Percutaneous Coronary Coronary Intervention Intervention Alberto Dominguez-Rodriguez, Pedro Abreu-Gonzalez, Sima Samimi- Park Haengnam, Secondary department of internal medicine,Kansai Fard, Eduardo Arroyo-Ucar, Ruben Juarez-Prera, Antonio Lara-Padrón, medical University, Moriguchi, Japan Francisco Bosa-Ojeda, Pablo Avanzas, Juan C. Kaski, Hospital Universitario de Canarias, Tenerife, Spain, St George’s Hospital., Learning Objective: evaluate London, United Kingdom

Low-Dose Aspirin May Ameriorate Long-Term Learning Objective: see a correlation between markers of 1217-320 inflammation and LV function. Neopterin may represent a useful Clinical Outcome in Patients with Coronary Spastic biomarker of LV dysfunction. Angina

Hitoshi Takano, Eisei Yamamoto, Shuhei Tara, Koji Kato, Shigenobu 1263-257 Plasma Myeloperoxidase Level Aids in Predicting Inami, Gen Takagi, Satoshi Aoki, Kuniya Asai, Masahiro Yasutake, Long-term Outcome of Acute Myocardial Infarction Kyoichi Mizuon, Nippon Medical School, Tokyo, Japan Mehmet Kaya, Ridvan Yalcin, Kaan Okyay, Fatih Poyraz, Nilufer Learning Objective: demonstrate the beneficial effect of aspirin in Bayraktar, Hatice Pasaoglu, Bulent Boyaci, Atiye Cengel, ERCIYES patients with coronary spastic angina UNIVERSITY, KAYSERI, Turkey Learning Objective: High plasma MPO levels identify patients with a worse prognosis after acute STEMI at two-year follow up period. Evaluation of plasma MPO levels may be useful at high risk patients, who might benefit A124 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1263-259 Clinical Outcome and Sensitive Troponin I Assay in 1264 UNSTABLE ISCHEMIC SYNDROME/BLEEDING Patients With Suspected Acute Coronary Syndrome ISSUES & OUTCOME Nicholas L. Mills, Antonia MD Churchhouse, Atul Anand, David Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Gamble, Margaret MacLeod, Catriona Graham, Simon Walker, Martin Denvir, Keith AA Fox, David E. Newby, The University of Edinburgh, Georgia World Congress Center, Hall B5 Edinburgh, United Kingdom, The Royal Infirmary of Edinburgh, Presentation Hour: 9:30 a.m. - 10:30 a.m. Edinburgh, United Kingdom CME/CE Hours: 1 Learning Objective: Understand that use of a sensitive troponin assay markedly increases the incidence of myocardial infarction and 1264-265 Major Bleeding Is an Independent Predictor of One- identifies patients at high-risk of reinfarction and death Year Post-discharge Mortality in Patients with Non- ST-Segment Elevation Acute Coronary Syndromes

1263-260 Elevated Plasma Myeloperoxidase as Indicator Renato Lopes, Karen P. Alexander, Anita Y. Chen, Tracy Y. Wang, Sunil for Vulnerable Plaque in Stable Patients with V. Rao, E. Magnus Ohman, Matthew T. Roe, Eric D. Peterson, Duke Significant Atherosclerotic Burden Clinical Research Institute, Durham, NC Wai Hong Wilson Tang, Yuping Wu, Stephen J. Nicholls, Stanley L. Learning Objective: Describe the long-term impact of in-hospital Hazen, Cleveland Clinic, Cleveland, OH major bleeding in patients with non-ST-segment elevation myocardial infarction. Learning Objective: To describe the role of myeloperoxidase as marker of vulnerable plaque in predicting risk of major adverse cardiac events in stable cardiac patients with significant 1264-266 Ticagrelor Versus Clopidogrel in Patients with Acute atherosclerotic plaque burden Coronary Syndromes Undergoing Coronary Artery By-pass Surgery: Results from the PLATO Trial

1263-261 Relationship of Inflammatory Biomarkers to the Claes Held, Jean Pierre Bassand, Richard C. Becker, Christopher Presence of Ischemia in Pateints with Coronary P. Cannon, Marc J. Claeys, Robert A. Harrington, Jay Horrow, Steen Artery Disease Undergoing Cardiac Stress Testing Husted, Stefan K. James, Kenneth W. Mahaffey, José C. Nicolau, Sylvia Olofsson, Benjamin M. Scirica, Robert F. Storey, Marius Salman Ashfaq, Peter El Haddad, Dory Abou Jaoude, Saad Iqbal, Vintila, Joseph Ycas, Lars Wallentin, Uppsala Clinical Research Syed Raffi, Samer Antonios, W Craig Hopper, University of Kansas Center and Dept of Cardiology, Uppsala University Hospital, School of Medicine-Wichita, Wichita, KS Uppsala, Sweden Learning Objective: Demonstrate relationship of inflammatory Learning Objective: Evaluate efficay and safety of patients with biomarker levels in the blood to the presence of myocardial acute coronary syndromes undergoing CABG surgery treated with ischemia in patients with known coronary artery disease ticagrelor or clopidogrel Serum Osteoprotegerin Levels and Long-Term 1263-262 Transfusing Old Stored Blood after an Early Invasive Prognosis in Subjects with Stable Coronary Artery 1264-267 Strategy for ACS is Associated with Increased Long- Disease Term Mortality Shuji Otsuki, Shuichi Jono, Yasutomi Higashikuni, Atsushi Shioi, Thomas P. Carrigan, Farzad Azimpour, Ming Shao, Priscilla Figueroa, Katsuhito Mori, Kengo Tanabe, Hiroyoshi Nakajima, Kazuhiro Hara, Michael Lincoff, Cleveland Clinic, Cleveland, OH Yoshiki Nishizawa, Yuji Ikari, Mitsui Memorial Hospital, Tokyo, Japan Learning Objective: Describe the association between old Learning Objective: interpret the association between serum transfused blood and mortality in an ACS population. osteoprotegerin (OPG) level and long-term prognosis in patients with stable coronary artery disease 1264-268 Correlation of Thrombus Area with Angiographic and Clinical Outcomes in Patients with ST-segment and Infarction 1263-263 Association of Genome Wide Loci for CAD with Distribution of Coronary Disease Elevation Myocardial Infarction Undergoing Primary Myocardial Ischemia PCI: Analysis from the HORISONS-AMI Trial Atif Qasim, Lena Matthews, Liming Qu, Rajesh Movva, Kambiz Parcham-Azad, Stephanie DerOhannessian, Jane Ferguson, Mingyao Yong He, Eugenia Nikolsky, Alexandra J. Lansky, Roxana Mehran, Li, Daniel J. Rader, Muredach P. Reilly, Hospital of the University of Adriano Caixeta, George Dangas, LeRoy Rabbani, Gregg W. Stone, Pennsylvania, Philadelphia, PA Cardiovascular Research Foundation and Columbia University Medical Center, New York, NY Learning Objective: Understand the nature of the genomewide asocation loci and their possible future use in CAD risk assessment Learning Objective: learn the impact of thrombus burden assessed by thrombus area on clinical outcomes JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A125

1264-269 Stent Thrombosis, Bleeding, and Antiplatelet 1265-276 Effect of Preinfarction Angina on Microvascular Therapy in the e-Select Registry: OneYear Follow- Function and Long-Term Outcome after Primary up of 15000 Patients Treated with the Sirolimus- Angioplasty for First Anterior Wall Myocardial eluting Cypher-Select Stent Plus Infarction

Philip M. Urban, Alexander Abizaid, Adrian Banning, Antonio Takefumi Takahashi, Yoshikazu Hiasa, Shin-ichiro Miyazaki, Shinobu Bartorelli, Vladimir Dzavik, Stephen G. Ellis, Runlin Gao, David Hosokawa, Koichi Kishi, Ryuji Ohtani, Tokushima Red Cross Holmes, Muyng Ho Jeong, Victor Legrand, Franz-Jozef Neumann, Hospital, Komatsushima, Japan Maria Nyakern, Christian Spaulding, Hans-Peter Stoll, Stephen Learning Objective: evaluate the effect of preinfarction angina Worthley, La Tour Hospital, Geneva, Switzerland on microvascular function and long-term outcome after acute Learning Objective: demonstrate the necessary balance between myocardial infarction thrombosis and bleeding after DES implantation, and the need for a RCT of the duration of dual antiplatelet treatment 1265-277 QRS Score at Hospital Discharge is a Strong Prognostic Marker in Patients with ST-Segment 1264-271 Temporal Trends in Cardiovascular Risk Factors and Elevation Myocardial Infarction Undergoing Primary Outcomes in Patients with Premature Coronary Percutaneous Coronary Intervention Artery Disease Michael C. Tjandrawidjaja, Yuling Fu, Cynthia M. Westerhout, Galen Farhan Javed Khawaja, Ryan Lennon, MS, Abhiram Prasad, MD, S. Wagner, Christopher B. Granger, Paul W. Armstrong, University of Mayo Clinic, Rochester, MN Alberta, Edmonton, AB, Canada Learning Objective: Identify the increasing prevalence of Learning Objective: Understand the prognostic utility of QRS scoring Cardiovascular Risk Factors in Young Patients Treated with PCI in patients with STEMI undergoing primary PCI

1264-272 Impaired Outcome with Acute Coronary Occlusions 1265-278 Application of the TIMI Risk Score, a Simple in Non-ST-Elevation Myocardial Infarction Bedside Tool, for Timing of Discharge after Fibrinolysis or Primary Angioplasty for ST-elevation Bjørnar Grenne, Christian Eek, Benthe Sjøli, Thomas Dahlslett, Michael Uchto, Per K. Hol, Helge Skulstad, Otto A. Smiseth, Thor MI in the ExTRACT-TIMI 25 and TRITON-TIMI 38 Edvardsen, Harald Brunvand, Sørlandet Hospital, Arendal, Norway, Trials Rikshospitalet University Hospital, Oslo, Norway Sean R. Wilson, Stephen D. Wiviott, Elliott M. Antman, Robert P. Learning Objective: describe outcome in patients with non-ST- Giugliano, Sabina A. Murphy, Sarah Sloan, Eugene Braunwald, David elevation myocardial infarction with and without acute coronary A. Morrow, Brigham and Women’s Hospital, Boston, MA occlusions Learning Objective: Evaluate the application of the TIMI risk score, a simple bedside tool, for timing of discharge after fibrinolysis or 1265 UNSTABLE ISCHEMIC SYNDROME/OUTCOMES & primary angioplasty in patients with ST-elevation MI. NOVEL RISK MODIFIERS 1265-279 Mitral Regurgitation after Myocardial Infarction Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Predicts Increased Medical Costs and Decreased

Georgia World Congress Center, Hall B5 Quality of Life: Analysis of the VALIANT (VALsartan Myocardial Ischemia In Acute myocardial iNfarcTion) Trial

Presentation Hour: 9:30 a.m. - 10:30 a.m. and Infarction CME/CE Hours: 1 Daniel William Mudrick, Shelby D. Reed, Yanhong Li, John JV McMurray, Lars Kober, Robert M. Califf, Eldrin F. Lewis, Scott D. 1265-273 Living Alone and Outcomes after Hospitalization for Solomon, Eric J. Velazquez, Duke Clinical Research Institute, Acute Myocardial Infarction Durham, NC

Emily M. Bucholz, Saif S. Rathore, Kensey Riley, Amy Schoenfeld, Learning Objective: describe the association between mitral John A. Spertus, Harlan M. Krumholz, Yale University School of regurgitation and subsequent costs and quality of life after Medicine, New Haven, CT, Mid America Heart Institute, University of myocardial infarction. Missouri-Kansas City, Kansas City, MO Myocardial Infarction Symptom Presentation and Learning Objective: Characterize the association between living 1265-280 Hospital Mortality: Relationship to Age and Sex alone and long-term mortality, rehospitalization, and quality of life after myocardial infarction in the National Registry of Myocardial Infarction (NRMI)

1265-274 Association of Body Mass Index and Mortality after John G. Canto, William J. Rogers, Robert J. Goldberg, Eric D. Acute Myocardial Infarction Peterson, Nanette K. Wenger, Viola Vaccarino, Catarina I. Kiefe, Paul Frederick, George Sopko, Z. J. Zheng, Watson Clinic, Lakeland, FL, Emily M. Bucholz, Saif S. Rathore, Kimberly J. Reid, John A. Spertus, National Heart, Lung, and Blood Institute, Bethesda, MD Harlan M. Krumholz, Yale University School of Medicine, New Haven, CT, Mid America Heart Institute, University of Missouri-Kansas City, Learning Objective: Understand the relationship between symptom Kansas City, MO presentation, mortality by sex and age following MI. Learning Objective: Describe the relationship between body mass index (BMI) and long-term mortality after myocardial infarction A126 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1266 UNSTABLE ISCHEMIC SYNDROME/PCI & 1266-288 Impact of Hyperglycemia On Long-Term Clinical OUTCOMES Outcomes In Patients With Non-ST Elevation Acute Coronary Syndromes Treated With Percutaneous Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Coronary Intervention Georgia World Congress Center, Hall B5 Ryan J. Magnuson, Justin B. Lundbye, Francis J. Kiernan, Abdul Presentation Hour: 9:30 a.m. - 10:30 a.m. Alkeylani, Thomas Schultz, Daniel S. Stewart, Kevin Dougherty, CME/CE Hours: 1 Dadong Li, Jeffrey Mather, Deborah Murphy, Raymond G. McKay, Hartford Hospital, Hartford, CT Prospective Randomized Comparison Between 1266-282 Learning Objective: Demonstrate the negative impact of XienceV and Cypher Stents hyperglycemia at the time of percutaneous coronary intervention Ad J. Van Boven, Sjoerd H. Hofma, Michel Quere, Jan Brouwer, in patients presenting with non-ST elevation acute coronary Cees-Jan de Vries, Evalien Kolkman, Heart Centre Friesland, MCL, syndromes. Leeuwarden, The Netherlands, Diagram BV, Zwolle, The Netherlands High-dose Plasmid-mediated Vascular Endothelial Learning Objective: Learn that new generation stents should be 1266-289 Growth Factor Gene Transfer in Patients With compared by the best of the old generation, i.e. Cypher Severe Coronary Artery Disease (GENESIS-I). Six Months Results of the First Phase I Latin American 1266-283 Percutaneous Coronary Intervention In Native Vessels With Angiographically Visible Thrombus. Trial of Gene Therapy in Myocardial Ischemia Temporal Trends and the impact of drug eluting Liliana Ethel Favaloro, Mirta Diez, Oscar Mendiz, Leon Valdivieso, stents Andres Bercovich, Marcelo E. Criscuolo, Gustavo Vera Janavel, Alberto J. Crottogini, Favaloro University Hospital, Buenos Aires, manivannan srinivasan, Charanjit S. Rihal, Mandeep Singh, Ryan J. Argentina, Bio Sidus, Buenos Aires, Argentina Lennon, David R. Holmes, Abhiram Prasad, Mayo Clinic, Rochester, MN Learning Objective: demonstrate safety of high-dose plasmid- mediated gene therapy Learning Objective: get an idea about temporal trends in PCI for patients with angiographically visible thrombus and the safety and efficacy of DES in such lesions. 1267 STABLE ISCHEMIC SYNDROME--NOVEL RISK MARKERS FOR VASCULAR DISEASE AND Long-Term Outcome of Bare Metal Stent vs. Drug- 1266-284 SUCCESSFUL INTERVENTION Eluting Stent Implantation in Octogenarians Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Junya Matsumi, Shigeru Saito, Junko Honne, Satoshi Takeshita, Shinji Tanaka, Saeko Takahashi, Yutaka Tanaka, Hidetaka Suenaga, Georgia World Congress Center, Hall B5 Shingo Mizuno, Nobuhiro Okamura, Kazuya Sugitatsu, Takuya Presentation Hour: 9:30 a.m. - 10:30 a.m. Izumikawa, Kouki Shishido, Shonan Kamakura General Hospital, CME/CE Hours: 1 Kamakura, Japan Learning Objective: We demonstrated that decision-making for DES- 1267-302 Prognostic Significance of Serum Resistin Levels implantation in octogenarians will require careful assessment of the in Patients Undergoing Percutaneous Coronary risk of bleeding complication. Intervention Yukihiko Momiyama, Reiko Ohmori, Ryuichi Kato, Hiroaki Taniguchi, 1266-285 Does “The Obesity Paradox” exist for survival after a Haruo Nakamura, Fumitaka Ohsuzu, NHO Tokyo Medical Center, Percutaneous Intervention? Tokyo, Japan, National Defense Medical College, Saitama, Japan Anitha Rajamanickam, Samir Kapadia, Sam Butler, Stephen Ellis, Learning Objective: interpret prognostic significance of serum

and Infarction James B. Young, Cleveland Clinic, Cleveland, OH resistin levels in patients undergoing PCI

Myocardial Ischemia Learning Objective: Does obesity paradox exists in patients after a percutaneous catheterization? 1267-303 Granulocyte-Colony Stimulating Factor in Angina Patients with Ischaemic Heart Diesase to Stimulate 1266-286 Long-Term Safety Profile of XIENCE V Everolimus- Neovascularisation (GAIN II Trial) Eluting Compared to TAXUS Express Paclitaxel- Sharon S. Chih, Peter Macdonald, Jane A. McCrohon, David Ma, Eluting Stents Moore John, Matthew Law, Michael P. Feneley, Andrea Herbert, Jason C. Kovacic, Robert M. Graham, Victor Chang Cardiac Research Robert J. Applegate, Krishnankutty Sudhir, James B. Hermiller, Julie Institute, Sydney, Australia, St Vincent’s Hospital, Sydney, Australia Doostzadeh, Shui Yu, Kyoko Hattori, Alexandra J. Lansky, Donald E. Cutlip, Charles A. Simonton, Gregg W. Stone, Wake Forest University Learning Objective: Evaluate the use of granulocyte colony School of Medicine, Winston-Salem, NC stimulating factor to treat angina in patients with severe ischaemic heart disease Learning Objective: To distinguish rates of late adverse events after first and second generation drug-eluting stents. JACC March 9, 2010 ABSTRACTS: Myocardial Ischemia and Infarction A127

1267-304 Incremental Risk Stratification in Stable Patients 1268-309 The Utility of Adenosine Stress-Rest Cardiac Undergoing Elective Cardiac Catheterization with Magnetic Resonance Imaging in Evaluating Cardiac Cardiac Biomarker Score (CBS) Function and Perfusion in Women with Systemic Lupus Erythematosus Wai Hong Wilson Tang, Yuping Wu, Alan Pratt, Michael Pepoy, Shirley Mann, Stanley L. Hazen, Cleveland Clinic, Cleveland, OH Pavel Goykhman, Louise E.J. Thomson, Yuching Yang, Leslee J. Shaw, Daniel S. Berman, Edward Gill, Mariko L. Ishimori, Rebecca Learning Objective: To describe the incremental value of combining Martin, Daniel J. Wallace, Jay N. Schapira, Chrisandra L. Shufelt, muliple cardiac biomakers to predict future risk of major adverse Michael H. Weisman, C. Noel Bairey Merz, Women’s Heart Center, cardiac events in stable cardiac patients Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 1267-305 Usefulness of Soluble Fms-like Tyrosine Kinase Learning Objective: Describe the utility of CT and MRI for 1 as a Biomarker of Acute and Chronic Phase of identification of atherosclerotic plaque and ischemia in Systemic Coronary Artery Disease Lupus Erythematosus patients.

Shiro Uemura, Kenji Onoue, Ken-ichi Ishigami, Satoshi Somekawa, 1268-310 Impact of Myocardial Viability on Echocardiographic Tsuneari Soeda, Satoshi Okayama, Hiroyuki Kawata, Manabu Horii, Parameters of Cardiac Structure and Function in Yoshihiko Saito, Nara Medical University, Kashihara, Nara, Japan Patients with Ischemic Cardiomyopathy. A Report Learning Objective: demonstrate that plasma soluble Flt-1 is not from the STICH Trial only a biomarker for CAD, but also plays an important role in the development of CAD Federico M. Asch, Thomas A. Holly, Lilin She, Gerald Maurer, Jacek Myc, William A. Zoghbi, Anna Teresinska, Bozena Birkenfeld, Eric High Circulating Levels of Tenascin-c Were J. Velazquez, Patricia A. Pellikka, Christopher Adlbrecht, Robert O. 1267-306 Bonow, Julio A. Panza, Washington Hospital Center, Washington, DC, Associated with Coronary Arterial Calcification in Northwestern University Feinberg School of Medicine, Chicago, IL Patients with Stable Effort Angina Pectoris Learning Objective: describe the association of myocardial viability Sakamoto Nobuo, Kazuhiko Nakazato, Hiroyuki Kunii, Tomofumi with the severity of cardiac structure and hemodynamic compromise Misaka, Hiroyuki Mizukami, Koichi Sugimoto, Shu-ichi Saitoh, in patients with ischemic cardiomyopathy Toshiyuki Ishibashi, Yasuchika Takeishi, Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan 1268-311 Utility of Stress Echocardiography for Predicting Learning Objective: Circulating tenascin-C is related to the degree of Long Term Cardiac Outcomes Among Patients coronary calcification in the patients of stable angina. Tenascin-C is Undergoing Liver Transplant Surgery a novel biomaker of coronary calcification. Anas Safadi, Kathleen A. Lane, Stephen G. Sawada, Jo Mahenthiran, Krannert Institute of Cardiology, Indiana University, 1268 STABLE ISCHEMIC SYNDROME--NONINVASIVE Indianapolis, IN ASSESSMENT OF CAD AND PVD Learning Objective: Identify the utility of stress echocardiography for predicting long term cardiac outcomes in patients undergoing liver Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. transplant surgery. Georgia World Congress Center, Hall B5

Presentation Hour: 9:30 a.m. - 10:30 a.m. Myocardial Ischemia

CME/CE Hours: 1 1269 STABLE ISCHEMIC SYNDROME--CLINICAL and Infarction DRIVERS OF RISK AND OUTCOMES A Randomized Controlled Trial of Fractional Flow 1268-307 Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Reserve to Optimize Percutaneous Coronary Georgia World Congress Center, Hall B5 Intervention Presentation Hour: 9:30 a.m. - 10:30 a.m. Eric Durand, Martine Gilard, Alain Furber, Pierre Coste, Michel Slama, CME/CE Hours: 1 Jean Luc Dubois-Randé, Paul Barragan, Patrick Dupouy, Saliha Rahal, Antoine Lafont, University Paris Descartes, Paris, France 1269-313 Impact of Residual Myocardial Jeopardy Learning Objective: To evaluate the value of FFR for stent on Long-Term Outcome Following Coronary deployment optimization. Revascularization in Patients With Type 2 Diabetes Mellitus 1268-308 The Utility of CARDx Early Cardiac Diagnostic System for the Detection of Coronary and Leonard Schwartz, Marnie Barolet, Frederick Feit, Charles J. Davidson, Mehrdad S. Toosi, Edward Y. Sako, Spencer B. King, III, Peripheral Artery Disease BARI 2D Study Group, Toronto General Hospital, Toronto, Canada Asha P. Mansukhani, Ehtisham Mahmud, University of California San Learning Objective: to detrmine the impact of incomplete Diego, San Diego, CA revascularization in patients with diabetes mellitus Learning Objective: Evaluate a new diagnostic modality for detecting coronary artery disease and peripheral artery disease A128 ABSTRACTS: Myocardial Ischemia and Infarction JACC March 9, 2010

1269-314 Association of Coronary Risk Factors with Proximal 1270-320 Prognosis of Asymptomatic Coronary Artery and Distal Atherosclerosis Disease after Percutaneous Coronary Intervention

Atif Qasim, Lena Matthews, Rajesh Movva, Kambiz Parcham-Azad, Kohei Wakabayashi, Cedric Delhaye, Gabriel Maluenda, Itsik Ben- Daniel J. Rader, Muredach P. Reilly, Hospital of the University of Dor, Manuel A. Gonzalez, Sara D. Collins, Asmir I. Syed, Michael A. Pennsylvani, Philadelphia, PA Gaglia, Rebecca Torguson, Zhenyi Xue, William O. Suddath, Lowell F. Satler, Kenneth M. Kent, Augusto D. Pichard, Joseph Lindsay, Ron Learning Objective: Describe the differences between risk factors Waksman, Washington Hospital Center, Washington DC, DC and location of coronary atherosclerotic lesions Learning Objective: In patients undergoing elective PCI, the absence 1269-315 Long term Impact of Race/Ethnicity on Death, of symptom is associated with an increase in one-year mortality. Myocardial Infarction and Stroke among patients enrolled in the Bypass Angioplasty 1270-321 A Comparison of Clinical Outcomes in the Bypass Revascularization Investigation of Type 2 Diabetes Angioplasty Revascularization Investigation in Type- Trial (BARI 2D) 2 Diabetes Mellitus (BARI 2D) by Type of Stent Implantation Nirat Beohar, Veronica Sansing, V.S. Srinivas, Andrew Davis, Stephen Thomas, Tarek Helmy, Luis Lepe, Maria Brooks, BARI 2D Vankeepuram S. Srinivas, Jiang Lu, John J. Lopez, Jorge Escobedo, Study Group, Northwestern University, Chicago, IL, University of GS Das, Zoran S. Nedeljkovic, Vijay Misra, Eric Bates, on behalf of Pittsburgh, Pittsburgh, PA the BARI2D Investigators, Montefiore Medical Center, New York, NY, University of Pittsburgh, Pittsburgh, PA Learning Objective: Race/ethnic differences in patients with DM and CAD Learning Objective: Compare clinical outcomes in patients with Diabetes and Coronary Disease receiving percutaneous 1269-316 Relationship between Erectile Dysfuntion and revascularization with drug eluting stents or bare metal stents to Coronary Artery Calcification in a population of Medical therapy in the BARI2D clinica Middle Aged Men in the World Trade Center Medical Monitoring and Treatment Program. 1270-322 Prevalence of Angina after Successful PCI

Sima J. Patel, Mary Ann A. McLaughlin, Boback M. Berookhim, Rupa Alda Huqi, Doralisa Morrone, Eugenia Capati, Rossella Urselli, Mario L. Iyengar, Danielle R. Platt, Simonette T. Sawit, Jaqueline M. Moline, Marzilli, Cardiac and Thoracic Department, University of Pisa, Pisa, Natan Bar-Chama, Mount Sinai School of Medicine, New York, NY Italy, Department of Cardiology, University of Siena, Siena, Italy Learning Objective: evaluate the association of erectile dysfunction Learning Objective: Removal of coronary stenosis does not with cardiovascular disease based on coronary artery calcium scores. consistently cure angina. Clinical Characteristics and Outcomes of 1269-317 Does the SYNTAX Score Have a Relation with 1270-323 Myocardial Ischemia? Japanese Female Patients Undergoing Coronary Revascularization Therapy Hirokazu Tanaka, Taishiro Chikamori, Satoshi Hida, Yuko Igarashi, Yuka Ohtaki, Chie Shiba, Yasuhiro Usui, Tsuguhisa Hatano, Akira Shunsuke Funakoshi, Natsuhiko Ehara, Takeshi Kitai, Makoto Yamashina, Department of Cardiology, Tokyo Medical University, Kinoshita, Atsushi Kobori, Shuichirou Kaji, Atsushi Yamamuro, Toko, Japan Tomoko Tani, Michihiro Nasu, Yukikatsu Okada, Toru Kita, Yutaka Furukawa, Takeshi Morimoto, Takeshi Kimura, Kobe City Medical Learning Objective: evaluate the relation between SYNTAX score and Center General Hospital, Kobe, HI, Japan, Kyoto University Hospital, myocardial ischemia assessed by stress myocardial perfusion SPECT Kyoto, Japan Learning Objective: interpret gender differences in risk factor 1270 STABLE ISCHEMIC SYNDROME-- profiles and cardiovascular outcomes for patients with coronary artery disease. and Infarction REVASCULARIZATION IN SPECIAL POPULATIONS

Myocardial Ischemia Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1

1270-319 Lack of Sex-Based Differences in Outcomes in Patients with Type 2 Diabetes and Coronary Artery Disease Treated with Contemporary Medical Therapy with or without Prompt Revascularization: A Report from BARI 2D

Jacqueline E. Tamis-Holland, Jiang Lu, Mary Korytkowski, William J. Rogers, Neuza Lopes, Michelle Magee, Lisa Mighton, Alice K. Jacobs, BARI 2D Investigators, St Luke’s Hospital, New York, NY, University of Pittsburgh, Pittsburgh, PA Learning Objective: Understand that there are little differences in outcome among women and men, when they are equally aggressively treated for coronary artery disease. JACC March 9, 2010 ABSTRACTS: Quality of Care and Outcomes Assessment A129

ORAL CONTRIBUTIONS

918 COMPARATIVE EFFECTIVENESS AND OUTCOMES 920 OUTCOMES IN CHRONIC HEART FAILURE Tuesday, March 16, 2010, 8:00 a.m. - 9:30 a.m. Tuesday, March 16, 2010, 10:30 a.m. - 12:00 p.m. Georgia World Congress Center, Room B404 Georgia World Congress Center, Room B404 CME/CE Hours: 1.5 CME/CE Hours: 1.5

8:00 Outpatient Compliance with Performance Measures 10:30 Post Discharge Management Programs for Elderly for Atrial Fibrillation: A Report of the first 14,000+ Heart Failure Patients: A Systematic Review and Patients from the American College of Cardiology’s Meta-Analysis of Randomized Clinical Trials IC3 (Improving Continuous Cardiac Care) Program Sanjeev Suri, Adrian Hernandez, Ali Usmani, Anitha Rajamanickam, Paul Chan, Stuart Winston, Donna Buchanan, Fran F. Fiocchi, Cleveland Clinic, Cleveland, OH Fengming Tang, Kristi Mitchell, Tracie Breeding, William J. Oetgen, Learning Objective: describe the effectiveness of disease John S. Rumsfeld, Carole Decker, John A. Spertus, Mid America management programs in reducing readmissions and mortality for Heart Institute, Kansas City, MO, The American College of hospitalized elderly heart failure patients Cardiology, Washington DC, DC Learning Objective: Describe the quality of outpatient non-valvular 10:45 Health Related Quality of Life and Functional atrial fibrillation care in a large registry. Class Are Independently Related to Outcomes in Unselected Outpatients with Heart Failure: Insights 8:15 Early Physician Follow-Up and 30-Day Readmission from the Study of Anemia in a Heart Failure among Medicare Beneficiaries Hospitalized with Population (STAMINA-HFP) Registry Heart Failure: Data from OPTIMIZE-HF and GWTG-HF Jalal K. Ghali, Jun R. Chiong, Javed Butler, William G. Cotts, Adrian F. Hernandez, Melissa A. Greiner, Gregg C. Fonarow, Bradley Stephanie . H. Dunlap, J. Herbert Patterson, Ron M. Oren, Ileana L. G. Hammill, Paul A. Heidenreich, Clyde Yancy, Eric D. Peterson, Piña, Douglas D. Schocken, Todd A. Schwartz, Kirkwood F. F. Adams, Lesley H. Curtis, Duke Clinical Research Institute, Durham, NC, Jr, University of North Carolina, Chapel Hill, NC, Detroit Medical University of California-Los Angeles, Los Angeles, CA center, Detroit, MI Learning Objective: Evaluate the relationship of early follow-up and Learning Objective: Demonstrate an understanding of the readmission after a hospitalization for heart failure relationship of health related quality of life to prognosis in patients with heart failure. 8:30 The Relation Between Hospital Procedure Volume and Complications of Cardioverter-Defibrillator 11:00 Influence of Predictive Modeling in Implementing Implantation from the National Cardiovascular Data Optimal Heart Failure Therapy Registry Dwight D. Stapleton, Hari Prasad, Jaspinder Sra, Wayne C. Levy, MD, James V. Freeman, Yongfei Wang, Jeptha Curtis, Paul A. Heidenreich, GUTHRIE CLINIC, LTD, SAYRE, PA Mark Hlatky, Stanford University School of Medicine and Palo Alto Learning Objective: Describe the influence of using the Seattle Veterans Affairs Health Care System, Stanford, CA, Yale University Heart Failure Model in the intensification of both device and School of Medicine, New Haven, CT medical therapy in an ambulatory heart failure population. Learning Objective: At the conclusion of this presentation, participants will be able to identify the effect of hospital ICD implant 11:15 Which Adiposity Measure Is a Better Predictor of volume on procedural complications. Cardiovascular Morbidity Risk Factors and Mortality in Obese Patients with Heart Failure?

8:45 Methods of Evaluating Comparative Effectiveness in Outcomes Assessment Observational Studies: The Example of Drug-Eluting Nancy M. Albert, James F. Bena, Anne S. Tang, Jennifer Forney, Ellen Quality of Care and and Bare Metal Stents Slifcak, Cleveland Clinic, Cleveland, OH Learning Objective: Distinguish predictors of morbidity and mortality Robert W. Yeh, Malini Chandra, Alan S. Go, Massachusetts General in obese patients with heart failure based on adiposity measure Hospital, Boston, MA, Kaiser Division of Research, Oakland, CA studied. Learning Objective: describe alternative methods of evaluating comparative effectiveness from observational data. 11:30 Relationship between Cardiology Practice Teaching Status and Improvement in the Use of Evidence- 9:00 Introducing ASCERT: The American College of Based Therapy for Heart Failure: Findings from Cardiology-The Society of Thoracic Surgeons IMPROVE HF Collaboration on the Comparative Effectiveness of Revascularization Strategies Christopher M. O’Connor, Gregg C. Fonarow, Nancy M. Albert, Anne B. Curtis, Wendy Gattis Stough, Mihai Gheorghiade, J Thomas William S. Weintraub, Fred Edwards, Study Co-Investigators, Heywood, Mark L. McBride, Patches Johnson Inge, Mandeep R. American College of Cardiology Foundation, Washington, DC, The Mehra, Dwight Reynolds, Mary N. Walsh, Clyde W. Yancy, Medtronic, Society of Thoracic Surgeons, Chicago, IL Inc., Minneapolis, MN Learning Objective: Describe the comparative effectiveness Learning Objective: To evaluate the relationship between cardiology research being performed by ACCF and STS to compare PCI with practice teaching status and improvement in the use of evidence- CABG, funded by an NHLBI Grant. based therapy for heart failure A130 ABSTRACTS: Quality of Care and Outcomes Assessment JACC March 9, 2010

POSTER CONTRIBUTIONS

1027 GENETICS AND CARDIAC EVENTS 1028 PHARMACOGENOMICS Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1027-154 Regulation of Plasma ET-1 Levels by Chromosome 1028-160 Warfarin Dosing Algorithm Refinements after 4q25 SNP Associated With Atrial Fibrillation 7-9 Days of Therapy based on Pharmacogenetic, Pharmacokinetic, Clinical, and Laboratory Data Fadia Mayyas, Jonathan D. Smith, John Barnard, Mina K. Chung, David R. Van Wagoner, Cleveland Clinic, Cleveland, OH Benjamin D. Horne, Petra A. Lenzini, Mia Wadelius, Andrea L. Jorgensen, Stephen E. Kimmel, Niclas Eriksson, Jeffrey L. Anderson, Learning Objective: To describe the association between Munir Pirmohamed, Nita A. Limdi, James K. Burmester, Daniel rs2200733 genotype, a SNP associated with atrial fibrillation, and Kurnik, Charles M. Stein, Michael D. Caldwell, Charles S. Eby, plasma endothelin-1 levels Anders Rane, John D. Lindh, Jae-Gook Shin, Ho-Sook Kim, Pantep Angchaisuksiri, Jinbo Chen, John F. Carlquist, Gloria R. Grice, Meta-analysis of the Association Between a 1027-155 Kathryn E. Kronquist, Brian F. Gage, Intermountain Medical Center, Common Variant in the Beta-2 Adrenergic Receptor Murray, UT, University of Utah, Salt Lake City, UT and Sudden Cardiac Death Learning Objective: Demonstrate that a warfarin dose-refinement Michael C. Gavin, Christopher Newton-Cheh, Martin Van Denbergh, algorithm, which incorporates pharmacogenetic data, provides J Michael Gaziano, Nancy R. Cook, Christine M. Albert, Brigham and better prediction of therapeutic warfarin dose. Women’s Hospital, Boston, MA, Massachusetts General Hospital, Boston, MA 1028-161 Pravastatin Therapy Among All Ethnic Groups of Learning Objective: Demonstrate an understanding of the CARE Reduced Primary End Point Events in Carriers association between polymorphisms in the beta adrenergic of the KIF6 719Arg Allele, but not in Noncarriers receptors and sudden cardiac death Dov Shiffman, Marc S. Sabatine, Judy Z. Louie, Charles M. Rowland, Olga A. Iakoubova, Hannia Campos, Frank M. Sacks, James J. Trigger-Specific Risk Factors for Cardiac Events in 1027-156 Devlin, Celera, Alameda, CA Patients with the Congenital Long-QT Syndrome Type 2 Learning Objective: Evaluate the benefit of pravastatin therapy among carriers and noncarriers of the 719Arg allele of KIF6 James A. Kim, Arthur J. Moss, Coeli M. Lopes, Scott McNitt, Jennifer L. Robinson, Wojciech Zareba, Ilan Goldenberg, University 1028-162 The Influence of Cytochrome P450 2C19*2 and*17 of Rochester Medical Center, Rochester, NY Genotype, Diplotype and Metabolizer Status on Learning Objective: Identify trigger-specific clinical and genetic risk Platelet Reactivity in Patients on Maintenance factors in patients with the Type 2 Long-QT syndrome. Clopidogrel Therapy

Genetic Factors Associated with Non-fatal Paul A. Gurbel, Udaya S. Tantry, Mark J. Antonino, Kevin P. Bliden, 1027-157 Ruth E. Pakyz, Alan R. Shuldiner, Sinai Center for Thro,bosis Myocardial Infarction and Hospitalized Unstable Research, Baltimore, MD, University of Maryland School of Angina - A Marshfield Clinic Case-Cohort Study Medicine, Baltimore, MD Deanna S. Cross, Daniel Hoefner, Evangelos Hytopoulos, WuXiong Learning Objective: To determine whether CYP2C19*2 and*17 Li, Bruce H. Phelps, Michael Beggs, Douglas S. Harrington, Edward allele status influences platelet reactivity in response to clopidogrel R. McCluskey, Catherine A. McCarty, Marshfield Clinic Research therapy Foundation, Marshfield, WI, Aviir Inc., Palo Alto, CA Learning Objective: describe an approach to study the impact of 1028-163 Cytochrome 2C19 Polymorphism and Response to adding genetics to the detection of those at risk of a coronary Adjunctive Cilostazol versus High Maintenance-dose event. Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention 1027-158 Correlation of Mutation Location and Ion Channel

Quality of Care and Young-Hoon Jeong, Seok-Jae Hwang, Yongwhi Park, In-Suk Kim,

Outcomes Assessment Characteristics with Cardiac Event Triggers in Long Choong Hwan Kwak, Jin-Yong Hwang, Gyeongsang National QT Syndrome Type 1 University Hospital, Jinju, South Korea Princy Thottathil, Arthur J. Moss, Coeli M. Lopes, Scott McNitt, Learning Objective: Among patients with CYP2C19 mutant allele Wojciech Zareba, Jennifer L. Robinson, Ilan Goldenberg, The undergoing elective PCI, adjunctive cilostazol achieves intensified International Long QT Syndrome Investigative Group, University of platelet inhibition and reduces the rate of HPPR than high-MD Rochester Medical Center, Rochester, NY clopidogrel. Learning Objective: Evaluate trigger-specific clinical and genetic risk factors for cardiac events in the LQT1 population. JACC March 9, 2010 ABSTRACTS: Quality of Care and Outcomes Assessment A131

1028-164 Estimation of Incremental Cardiovascular 1030 COST OF CARE IN CARDIOVASCULAR DISEASE Healthcare Costs in Patients with Atrial Fibrillation in the United States Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Michael H. Kim, Stephen S. Johnston, Jay Lin, Kathy L. Schulman, Presentation Hour: 9:30 a.m. - 10:30 a.m. Northwestern University, Chicago, IL, Thomson Reuters, Cambridge, MA CME/CE Hours: 1 Learning Objective: appreciate that most of the cardiovascular healthcare costs incurred by patients with atrial fibrillation (AF) in the 1030-171 Medical Cost Burden and Outcomes after Acute US stem from management of CV comorbidities rather than AF per se. Myocardial Infarction

Sachin J. Shah, Saif S. Rathore, Aditya Mandawat, Kimberly J. Reid, 1029 GENOMICS AND MYOCARDIAL PHENOTYPES Oliver J. Wang, John A. Spertus, Harlan M. Krumholz, Yale University Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. School of Medicine, New Haven, CT, Mid America Heart Institute, Kansas City, MO Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Learning Objective: describe the association between the burden of medical costs and outcomes after acute myocardial infarction. CME/CE Hours: 1

1030-172 Statin Therapy is Cost-Effective for Vascular Event 1029-166 Prognostic Value of a Systematic Familial Screening Prevention in Adults with Elevated C-Reactive in Idiopathic Dilated Cardiomyopathy. The Protein: Implications of JUPITER Experience of Trieste Heart Muscle Disease Julia F. Slejko, Robert L. Page, II, Patrick W. Sullivan, University of Marco Merlo, Michele Moretti, Giulia Barbati, Dario Gregori, Andrea Colorado Denver School of Pharmacy, Aurora, CO, Regis University Di Lenarda, Luisa Mestroni, Gianfranco Sinagra, Ospedali Riuniti School of Pharmacy, Denver, CO and University, Trieste, Italy Learning Objective: evaluate the cost-effectiveness of statin therapy Learning Objective: Compare long-term prognosis of familial dilated for a population with low LDL cholesterol, but elevated hs-CRP. cardiomyopathy with respect to sporadic forms in order to assess the role of familial screening 1030-173 The Impact of Pharmacy Benefit Managers on Physician Practice Time, Cost, and Efficiency 1029-167 Nuclear Receptor Co-Activator-1 Modifies the Hypertrophic Cardiomyopathy Phenotype James A. Heinsimer, Danny A. Mammo, Phil Mendys, Kevin A. Schulman, Duke University, Durham, NC Nicole Orr, Amil M. Shah, Alyson Kelley-Hedgepeth, Daniel Kramer, Martin S. Maron, Gordon Huggins, Molecular Cardiology Research Learning Objective: understand how PBMs impact physician Institute, Boston, MA, Tufts Medical Center, Boston, MA practices Learning Objective: To identify and understand the role of potential genetic modifiers of the hypertrophic cardiomyopathy phenotype 1030-174 Total Healthcare Costs Among Atrial Fibrillation Patients in the United States in 2010

1029-168 Mutations in 6 Genes Identified in Patients With Michael H. Kim, Bong-Chul Chu, Jay Lin, Kathy L. Schulman, Peripartum Cardiomyopathy Northwestern University, Chicago, IL, Thomson Reuters, Cambridge, MA Ana Morales, Thomas Painter, Ran Li, Jill D Siegfried, Duanxiang Li, Nadine Norton, Miller School of Medicine, University of Miami, Miami, FL Learning Objective: appreciate the magnitude of the economic burden imposed by atrial fibrillation (AF) in the United States, Learning Objective: Describe evidence supporting the hypothesis and the substantial non-cardiovascular and cardiovascular cost that rare DCM variant mutations may contribute to PPCM/PACM. components of AF management Outcomes Assessment

Network Analysis of Epistatic Interactions among Quality of Care and 1029-169 Reappraisal of the Evaluation of Chest Pain in the Four Myocardial Fatty Acid Metabolism Candidate 1030-175 Emergency Room - A Modern Cost Analysis Just in Genes Modulating Hypertensive Heart Disease Time for Health Care Reform Lisa de las Fuentes, Jyh M. Juang, Sharlee Climer, Victor G. Davila- Fahd A. Chaudhry, Fatima Ilyas, Saira Rashid, Vincent Sorrell, Roman, Washington University, St. Louis, MO University of Arizona, Tucson, AZ Learning Objective: better understand the important role played by Learning Objective: Accurately estimate the cost of various stress epistasis with PPARGC1A in modulating HHD traits. tests, and identify factors adding to patient (and hospital) expense.

1029-170 Beta-1 Adrenergic Receptor Gene Polimorphism in Heart Failure: a Gender Specific Clinical and Prognostic Role?

Savina Nodari, Marco Triggiani, Anna Foresti, Giuseppe Milesi, Nicola Berlinghieri, Loredana Covolo, Livio Dei Cas, Department of Experimental and Applied Medicine-University of Brescia, Brescia, Italy Learning Objective: Beta-1 adrenergic receptor gene polimorphism may contribute to explain gender differences in clinical and functional profiles and outcomes in heart failure patients A132 ABSTRACTS: Quality of Care and Outcomes Assessment JACC March 9, 2010

1031 OUTCOMES RESEARCH: APPROPRIATENESS AND 1032 BIOMEDICAL COMPUTING/INFORMATION CLINICAL TRIALS REPORTING TECHNOLOGY Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1031-177 Adherence to the American College of Cardiology 1032-183 The Effect of Electronic Prescription Upon Foundation / American Society of Nuclear Attainment of Guideline-Based Cholesterol Goals Cardiology - 2009 Appropriate Use Criteria for Katherine C. Michelis, Bassel Hassouna, Mina Owlia, Yousef Bader, Cardiac Nuclear Imaging by Cardiologist and Non- Douglas V. Clarke, Jr., Lena Furmark, Shireen Khoury, Nina Kukar, Cardiologist in a Community Hospital Setting Rayan Alhazmi, Raman S. Dusaj, Vandana Toteja, Heather A. Young, Shanmugam Uthamalingam, Imad Ahmado, James Flynn, New Brian G. Choi, George Washington University, Washington, DC England Heart Institute at Catholic Medical Center, Manchester, NH, Learning Objective: identify the benefit of electronic prescription Division of Cardiology, Massachusetts General Hospital, Boston, MA upon National Cholesterol Education Program Adult Treatment Panel Learning Objective: to identify the importance of the application III (NCEP ATP III) guideline-based LDL goal attainment. of ACCF and ASNC recently published appropriateness criteria for cardiac nuclear imaging and incorporate them in their practice 1032-184 Trialresults-center: A Web-based Clinical Trial patterns. Results Database Providing Dynamic Systematic Reviews And Meta-analysis Of Clinical Trials In 1031-178 Predictors of Normal Single Photon Emission Cardiology Computed Tomography Myocardial Perfusion Michel Cucherat, TrialResults-center.org, Lyon, France Imaging Learning Objective: describe TrialResults-center approach Angela Koh, Jennifer Flores, Felix Keng, Terrance SJ Chua, National Heart Centre, Singapore, Singapore 1032-185 Clinical Validation of a Decision Support System for Learning Objective: Assessment of appropriateness for SPECT MPI Acute Coronary Syndromes

Trends in Appropriateness of Outpatient Robert F. DeBusk, Nancy Houston-Miller, Lynda Raby, Stanford 1031-179 University School of Medicine, Stanford, CA Transthoracic Echocardiography Learning Objective: Demonstrate familiarity with a computerized Ali Rahimi, Meghan York, Neil Gheewala, Thomas H. Hauser, Warren decision support system for patients with suspected acute coronary J. Manning, Beth Israel Deaconess Medical Center, Department of syndrome Medicine (Cardiovascular Division), Boston, MA Learning Objective: Identify Trends in Appropriateness of Outpatient 1032-186 A New Schema for Problem Lists: Towards Real- Echocardiography Time Decision Support

The Selection of Hard Clinical Endpoints versus Matthew McCormick, Thomas A. Windle, John R. Windle, University 1031-180 of Nebraska Medical Center, Omaha, NE Surrogate Endpoints as the Primary Outcome Measure in Major Cardiovascular Clinical Trials is Learning Objective: describe a more robust schema for problem list not Influenced by the Source of Funding management

Ashish Aneja, Ricardo Esquitin, Kshitij Shah, Louai Razzouk, 1032-187 A Computer Simulation Study of the Effectiveness Rupa Iyengar, Irfan Wali, Verghese Mathew, Michael E. Farkouh, of Left Ventricular Assist Device under Mitral MetroHealth Medical Center Campus of Case Western Reserve Regurgitation and Mitral Stenosis University, Cleveland, OH, Mount Sinai School of Medicine, New York, NY Salvatore Chiaramida, Michael L. Bernard, Adrian B. Van Bakel, Learning Objective: Recognize that the source of funding of major Joseph J. Thompson, John M. Toole, Ying Sun, Medical University cardiovascular clinical trials does not influence the choice of the of South Carolina, Charleston, SC, University of Rhode Island, primary outcome measure Kingston, RI

Quality of Care and Learning Objective: : Demonstrate the use of a computer model to Outcomes Assessment 1031-181 The Impact of Conflicts of Interest on Adjudication characterize the interaction between left ventricular assist devices and Outcomes in Cardiovascular Clinical Trials and the circulatory system under mitral valvular diseases.

Ricardo Esquitin, Ashish Aneja, Kshitij A. Shah, Louai Razzouk, Devin M. Mann, Joseph S. Ross, Rupa Iyengar, Irfan U. Wali, Verghese Mathew, Michael E. Farkouh, Mount Sinai School of Medicine, New York, NY, MetroHealth Medical Center Campus of Case Western Reserve University, Cleveland, OH Learning Objective: Indentify the impact of financial conflicts of interest on outcomes in cardiovascular trials. JACC March 9, 2010 ABSTRACTS: Quality of Care and Outcomes Assessment A133

1082 ECONOMIC OUTCOMES 1083 OUTCOMES ASSESSMENT METHODS Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1

1082-154 Government-Sponsored Health Insurance and Lack 1083-160 Red Cell Distribution Width Predicts Adverse of Insurance Are Associated with Adverse Cardiac Long Term Outcomes in Subjects with Suspected Events Coronary Disease

Michael Angelo Gaglia, Jr., Rebecca Torguson, Manuel A. Gonzalez, Riyaz S. Patel, Emir Veledar, Ronak Patel, Salman Sher, A Umair Zhenyi Xue, Itsik Ben-Dor, Sara D. Collins, Asimir I. Syed, Gabriel Janjua, Douglas C. Morris, John S. Douglas, Stephen D. Clements, S Maluenda, Cedric Delhaye, Kohei Wakabayashi, Nicholas N. Hanna, Tanveer Rab, Habib Samady, A Maziar Zafari, Viola Vaccarino, Arshed William O. Suddath, Kenneth M. Kent, Lowell F. Satler, Augusto D. A. Quyyumi, Emory University School of Medicine, Atlanta, GA Pichard, Ron Waksman, Washington Hospital Center, Washington, DC Learning Objective: Evaluate an existing and easily available test for Learning Objective: Describe the effect of different types of health prognostic utility in a cath lab population insurance upon 1-year outcomes after PCI. 1083-161 Would Observational Data have Predicted Results 1082-155 Money Left Over at the End of the Month and Found in Randomized Controlled Trials of Coronary Outcomes after Myocardial Infarction Revascularization?

Aditya Mandawat, Saif S. Rathore, Sachin J. Shah, Emily M. Bucholz, John B. Wong, Linda K. Shaw, Daniel B. Mark, Eric D. Peterson, Kimberly J. Reid, Oliver J. Wang, Joseph S. Ross, John A. Spertus, Peter K. Smith, Elizabeth R. DeLong, Tufts Medical Center, Boston, Harlan M. Krumholz, Yale University School of Medicine, New Haven, MA, Duke Clinical Research Institute, Durham, NC CT, Case Western Reserve University, Cleveland, OH Learning Objective: Understand the generalizability of patient Learning Objective: Characterize the relationship between self- populations enrolled in and the results observed in randomized reported patient financial stress and outcomes after acute controlled trials when compared with an observational dataset myocardial infarction 1083-162 Inclusion of Roll-in Patients in Pre-FDA Approval 1082-156 Cost-Effective Primary Prevention of Coronary Heart Cardiovascular Device Trials Disease in Intermediate Risk Patients: Universal Aspirin and Statins Is Superior to Prevention Guided Connie E. Chen, Sanket S. Dhruva, Lisa A. Bero, Rita F. Redberg, by Stress Testing University of California, San Francisco, San Francisco, CA Learning Objective: Define roll-in patient and characterize the use Benjamin Z. Galper, Andrew Moran, Mark J. Pletcher, Pamela and reporting of data from roll-in patients in recent cardiovascular Coxson, Lawrwence Lazar, Y. Claire Wang, Paul Heidenreich, Lee device studies Goldman, Columbia University Medical Center, New York City, NY, University of California San Francisco Medical Center, San Event Adjudication Changes Key Results in Open- Francisco, CA 1083-163 Label Trials: The AFFIRM Experience Learning Objective: Demonstrate the use of the CHD Policy Model to determine the Cost-Effectiveness of utilizing stress testing to Elaine M. Nasco, April Slee, Kent Koprowicz, Robert G. Hart, Axio improve the risk stratification of intermediate risk patients. Research, LLC, Seattle, WA Learning Objective: Interpret event rates using both adjudicated and 1082-157 Cost and Clinical Consequences of Stress/Single- unadjudicated events.

Photon Emission Computed Tomography Testing Outcomes Assessment Quality of Care and with Specific Medications 1083-164 Small Artery Elasticity, but neither Carotid Artery Elasticity nor Aorta Distensibility, Predicts Onur Baser, James Spalding, Smita Kothari, Maria Laura Monsalvo, STATinMED Research, Ann Arbor, MI, Astellas Pharma, Deerfield, IL Cardiovascular Events in an Asymptomatic - Results of the Multi-Ethnic Study of Atherosclerosis Learning Objective: Identify the cost of care and clinical events associated with dipyridamole vs. adenosine use in ST/SPECT Daniel A. Duprez, David R. Jacobs, Jr, Pamela L. Lutsey, David A. myocaridal perfusion testing using real-wordl data. Bluemke, David A. Bluemke, Lyndia C. Brumback, Jospeh Polak, Richard A. Kronmal, University of Minnesota, Minneapolis, MN 1082-158 Comparison of United States Hospitals’ Heart Learning Objective: interprete the predictive value of artial elasticity Failure Quality Care measures: A National Sample on CV events beyond blood pressure and CV risk factors. from 2005 - 2009

Jun R. Chiong, Celso Perez, Mark Ghamsary, Loma Linda University, Loma Linda, CA Learning Objective: to understand differences in performance measures For Profit Hospital (FP) and Not For Profit (NFP) hospital’s adherence to HF quality care measures. A134 ABSTRACTS: Quality of Care and Outcomes Assessment JACC March 9, 2010

1084 OUTCOMES OF REVASCULARIZATION 1085-171 Can the Syntax Score Be Used in Clinical Practice? Results of a Inter- and Intra-Observer Variability Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Study Georgia World Congress Center, Hall B5 Stéphane Zuily, Christophe Goetz, Julien Rosencher, Obay Oulmane, Presentation Hour: 3:30 p.m. - 4:30 p.m. Zoheir Mami, Stéphane Manzo-Silberman, Nicolas Marque, Philippe CME/CE Hours: 1 Allouch, Olivier Bical, Alain Pavie, Christian Spaulding, Olivier Varenne, Cardiology Department, Cochin Hospital, Paris, France 1084-166 What is the Right Definition of Contrast Induced Nephropathy Post Percutaneous Coronary Intervention? Learning Objective: Use the SYNTAX score in clinical practice

Refat Jabara, Radhika Gadesam, Lakshmana Pendyala, Nicolas Chronos, Jack Chen, Spencer King, Steven Manoukian, Hadassah- 1085 SCORING AND OUTCOMES Hebrew University Medical Center, Jerusalem, Israel, Saint Joseph’s Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Hospital, Atlanta, GA Georgia World Congress Center, Hall B5 Learning Objective: Learn about the practical impact of the Presentation Hour: 3:30 p.m. - 4:30 p.m. definition utilized on the rate of CIN post PCI CME/CE Hours: 1

1084-167 Impact of Chronic Obstructive Pulmonary Disease 1085-172 Preparticipation Screening of Athletes for Risk of on Cardiovascular Outcomes in Patients after PCI Sudden Death, a Solution to the Cost Factor Tomas Konecny, Marek Orban, Krishen Somers, Yuki Koshino, Paul Thomas DeBauche, Peter Razeghi, Connie Keasling, Phillip D. Scanlon, Charanjit S. Rihal, Mayo Clinic, Rochester, MN DeBauche, Andrew Collins, William Green, David Anthony, Cypress Learning Objective: identify worse prognosis for patients with COPD Cardiology PA, Cypress, TX undergoing PCI Learning Objective: Identify a low cost method of screening athletes for risk of SCD 1084-168 Quantification of Amplitude, Speed and Completeness of ST-segment Recovery after 1085-173 Improvement beyond the Framingham Risk Score Primary Percutaneous Coronary Intervention for for Prediction of Mortality by the Addition of the ST-segment Elevation Myocardial Infarction: What Is Intermountain Risk Score the “Best ST” Recovery to Predict Clinical Outcome? Benjamin D. Horne, Heidi T. May, Joseph B. Muhlestein, Donald L. Wichert J. Kuijt, Matthew T. Roe, Cindy L. Green, Niels J. Verouden, Lappé, Deborah Budge, Rami Alharethi, John F. Carlquist, Abdallah Joost D. Haeck, Dan Tzivoni, Karel T. Koch, Gregg W. Stone, G. Kfoury, Jeffrey L. Anderson, Intermountain Medical Center, Alexandra J. Lansky, Robbert J. De Winter, Mitchell W. Krucoff, Duke Murray, UT, University of Utah, Salt Lake City, UT Clinical Research Institute, Durham, NC Learning Objective: Examine the result of combining the Learning Objective: This study demonstrates that various measures Intermountain Risk Score with the Framingham Risk Score on risk of STR, representing duration and intensity of ischemia, are highly stratification. predictive of clinical outcome and are best captured by continuous 12-lead Holter 1085-174 Independent US validation of the British Columbia PCI Risk Score 1084-169 The Impact of Vascular Access Site Complications on One-Year Outcome in the Setting of PCI: A Reappraisal Rohit Khurana, Sharon-Lise T. Normand, Treacy Silbaugh, Karin H. Humphries, Min Gao, Lillian Ding, Ann Lovett, David J. Cohen, Erwin Schroeder, Dirck Faes, Jacques Jamart, Patrick Chenu, Vincent Jaap N. Hamburger, University of British Columbia, Vancouver, BC, Dangoisse, Patrick Evrard, Laurence Gabriel, Antoine Guedes, Canada Baudouin Marchandise, Emmanuel Morandini, Axel Muller, Jean- Louis Paquay, Godefroy Perot, Mont-Godinne University Hospital, Learning Objective: Identify with the international applicability of the YVOIR, Belgium British Columbia post PCI risk score to their practice Learning Objective: Identify a subgroup of bleeding events without Obstructive Ventilatory Disorder in Heart Failure: impact on survival 1085-175 Not Always COPD! 1084-170 Prognostic value of the Mayo Clinic Risk Score Susanne Brenner, Gülmisal Güder, Kilian Fröhlich, Götz Gelbrich, for coronary artery revascularization using the Roland Jahns, Berthold Jany, Georg Ertl, Christiane E. Angermann, Quality of Care and

Outcomes Assessment Australasian Society of Cardiac and Thoracic Surgeons Stefan Störk, University of Würzburg, Dept. of Internal Medicine, and the Melbourne Interventional Group Registries Würzburg, Germany

Bryan P. Yan, Cheng-Hon Yap, Nick Andrianopoulos, Thomas J. Learning Objective: In patients with HF, COPD is common but often Kiernan, Andrew E. Ajani, Julian A. Smith, David J. Clark, Stephen misdiagnosed (>70%). The correct diagnosis of COPD in patients J. Duffy, Gilbert C. Shardey, Angela L. Brennan, Diem T. Dinh, with heart failure may only be made in course of the disease. Christopher M. Reid, Bernard J. Gersh, Australasian Society of Cardiac and Thoracic Surgeons and Melbourne Interventional Group, Chinese University of Hong Kong, Hong Kong, Hong Kong, Monash University, Melbourne, Australia Learning Objective: Evaluate in-hospital mortality risk after coronary revascularization JACC March 9, 2010 ABSTRACTS: Quality of Care and Outcomes Assessment A135

1086 REVASCULARIZATION STRATEGIES 1087 IMAGINING AND OUTCOMES Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1

1086-177 Non-Invasive Assessment of Stent Fracture with the 1087-183 2D Echo Training for Cardiac Nurses: The Effects of Stent Boost Technique Intensive Repetition

Maria Papathanasiou, Evaggelia Zacharioglou, Periklis Davlouros, Michael J. Barrett, Garima Sharma, Kristy Schering, Alfred Bove, Lampros Papakosmas, Anastasia Damelou, Konstantinos Temple University, Philadelphia, PA Theodoropoulos, Vasileios Karantalis, Gerasimos Dimitropoulos, Learning Objective: Understand how to teach nurses to recognize Georgia Mitropoulou, Ioanna Xanthopoulou, Grigorios Tsigkas, normal echo images Dimitrios Alexopoulos, Patras University Hospital, Patras, Greece

Learning Objective: evaluate the incidence and clinical impact of 1087-184 Real Time Cellular Video-Phone Electrocardiogram stent fracture and the diagnostic utility of fluoroscopy in stent Transmission of Patients with ST-Segment Elevation fracture diagnosis Myocardial Infarction: A Novel Tele-Medicine Technology to Shorten Door-to-Balloon Time 1086-178 Fracture Potentials of Five Drug-Eluting-Stent Platforms in Proximal Right Coronary Artery Manuel A. Gonzalez, Sara D. Collins, Marie E. Rodrigo, Itsik Replica Under In-Vivo Simulated Cyclically-Bended Ben-Dor, Gabriel Maluenda, Asmir I. Syed, Michael A. Gaglia, Jr., Environment Cedric Delhaye, Kohei Wakabayashi, Rebecca Torguson, William O. Suddath, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard, Kiyotaka Iwasaki, Yutaro Hama, Tadashi Yamamoto, Yuichi Yagishita, Lowell F. Satler, Ron Waksman, Washington Hospital Center, Yusuke Noguchi, Syunsuke Tsubouchi, Ken Nakashita, Hiroshi Washington, DC Kasanuki, Mitsuo Umezu, Waseda University, Tokyo, Japan, Sapporo Learning Objective: familiarize themselves with new technology Orthopedic Cardiovascular Hospital, Sapporo, Japan using pre-hospital real time video cell phone ECG interpretation of Learning Objective: examine fracture potentials of five DES patients with STEMI platforms in proximal right coronary artery using a novel accelerated durability tester which can apply an in-vivo simulated cyclically- 1087-185 Virtual Electrophysiologic Testing In A Three- bended load dimensional Cardiac MRI Model Of Myocardial Infarction In Pigs 1086-179 Vascular Physiologic Responses Associated With Drug-Eluting Stents: Evaluation Of A Stent Eluting Jason Ng, Jason Jacobson, Justin Ng, David Gordon, Daniel Lee, Sirolimus From An Absorbable Salicylate Polymer Alan H. Kadish, James Carr, Jeffrey J. Goldberger, Northwestern Coating University, Chicago, IL Learning Objective: describe how electrophysiolic testing can be Refat Jabara, Lisa Goodwin, Nicolas Chronos, Traci Goodchild, performed using computer simulation Hadassah-Hebrew University Medical Center, Jerusalem, Israel, Saint Joseph’s Translational Research Institute, Atlanta, GA 1087-186 Free Software Improves Accuracy of Pediatric EKG Learning Objective: Flow Cytometry and Western Blot of New Decreasing Error by 45% Bioabsorbale Polymer Coating MARCOS SLEIMAN ,MOLINA, Alexandre Benjo, Alessandra Molina, Carlos A. Pastore, InCor - Heart Inst of Univ of Sao Paulo, Sao 1086-180 Do Appropriateness Criteria Adequately Assess the Usefulness of Repeat Echocardiograms Paulo, Brazil, Clinica Sao Paulo, Moji das Cruzes, Brazil Outcomes Assessment Quality of Care and Learning Objective: Validate the superiority of computer-aided Abhijit Ghatak, Raja C. Pullatt, David I. Silverman, Hartford hospital, evaluation of pediatric EKG Hartford, CT, University of Connecticut Health center, Farmington, CT Learning Objective: To evaluate Appropriateness criteria for repeat 1087-187 The utility Of a Novel Software in Lipid Clinic Transthoracic Echocardiogram. Demir Baykal, Medical Software,LLC, Duluth, GA Learning Objective: The utility of a novel software in lipid clinic A136 ABSTRACTS: Quality of Care and Outcomes Assessment JACC March 9, 2010

1137 DIABETES, LIPIDS, OBESITY 1138 OUTCOMES IN ACUTE CORONARY SYNDROMES Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1137-154 Influence Of Preoperative Diabetic Treatment Status 1138-160 Decline in Hospitalizations for Acute Myocardial On Long-term Cardiovascular Outcomes In Patients Infarction in a Metropolitan Population over Past With Type 2 Diabetes Mellitus Undergoing Coronary Decade Revascularization. Alan K. Berger, Lindsay G. Smith, David R. Jacobs, Jr, Russell V. Natsuhiko Ehara, Yutaka Furukawa, Takeshi Morimoto, Satoshi Luepker, University of Minnesota, Minneapolis, MN Shizuta, Makoto Kinoshita, Shuichiro Kaji, Atsushi Kobori, Atsushi Learning Objective: Identify the trends in acute myocardial infarction Yamamuro, Tomoko Tani, Takeshi Kitai, Satoshi Teramukai, Masanori in men and women in the Twin Cities over the past decade. Fukushima, Toru Kita, Takeshi Kimura, CREDO-Kyoto Investigators, Kobe City Medical Center General Hospital, Kobe, Japan, Kyoto Usual Source of Care and Outcomes after Acute University Hospital, Kyoto, Japan 1138-161 Myocardial Infarction: Data from the Prospective Learning Objective: evaluate the association between preoperative Registry Evaluating Myocardial Infarction: Event and diabetic treatment status and cardiovascular outcomes in patients Recovery (PREMIER) with type 2 diabetes mellitus after coronary revascularization. Erica S. Spatz, Mayur M. Desai, Kensey Riley, Joseph S. Ross, 1137-155 Adiposity Associated Mortality and Cardiovascular Sameer D. Sheth, John A. Spertus, Harlan M. Krumholz, Yale Events in Patients with Coronary Artery Disease University School of Medicine, New Haven, CT, Mid America Heart Institute of Saint Luke’s Hospital, Kansas City, MO YOEL KORENFELD, Felipe Albuquerque, Virend K. Somers, Rui Qin, Simona Boarin, Vijaykumar Jarsania, Abel Romero-Corral, Randall J. Learning Objective: Identify the strength of a relationship with Thomas, Francisco Lopez-Jimenez, Mayo Clinic, Rochester, MN a usual care provider, and describe the association between relationship strength with risk of mortality and readmission Learning Objective: Undesrtand the relationship of adiposity and following hospitalization for AMI cardiovascular outcomes in patients with coronary artery disease 1138-162 Temporal Trends Over 15 Years in Clinical Trials 1137-156 Loss of Early Gains in Low-Density Lipoprotein of Non-ST Elevation Acute Coronary Syndromes: Cholesterol Goal Attainment Among High Risk More Aggressive Treatment Yields Similar Mortality Patients Despite Higher-Risk Profiles

Joanne M. Foody, Shiva Sajjan, Henry Hu, Dena R. Ramey, David Mark Y. Chan, Jie-Lena Sun, L. Kristin Newby, Harvey D. White, David Neff, Andrew M. Tershakovec, Joanne E. Tomassini, Kaan Tunceli, J. Moliterno, Pierre Theroux, E. Magnus Ohman, Karen S. Pieper, Merck & Co., Inc., North Wales, PA Robert P. Giugliano, Paul W. Armstrong, Robert M. Califf, Frans Van Learning Objective: Describe the proportion of high risk patients de Werf, Robert A. Harrington, Duke Clinical Research Institute, treated and untreated with lipid lowering therapy with LDL-C levels Durham, NC ≥70mg/dL and the need for guideline based LDL-C lowering in Learning Objective: describe temporal patterns in baseline risk, these patients treatment, and outcomes of non-ST elevation acute coronary syndrome patients enrolled in randomized clinical trials over a 15- 1137-157 Effect of Intensive Blood-Glucose Control Compared year period. to Conventional Treatment on Cardiovascular Endpoints In Patients with Type 2 Diabetes 1138-163 Validation of the Global Registry of Acute Coronary Events (GRACE) risk score for 6-month Ganesh Athappan, Faisal M. Khan, Caritas St Elizabeth Medical postdischarge death in 1183 Spanish patients Center, Brighton, MA Learning Objective: identify the cardiovascular benefits of intensive emad abu assi, Jose Maria Garcia-Acuna, Carlos Pena-Gil, Rafael glucose control inpatients with type II diabetes. Carlos Vidal Perez, Jose Ramon Gonzalez-Juanatey, Hospital Clínico Universitario, Santiago de Compostela, Spain Learning Objective: To evaluate the performance of the GRACE risk Quality of Care and

Outcomes Assessment score for 6-month post-discharge death

1138-164 Matching National EMS System Data to the NCDR ACTION Registry to Identify First Medical Contact Time.

James G. Jollis, Seth W. Glickman, Christopher B. Granger, Greg D. Mears, Duke University, Durham, NC, EMS Performance Improvement Center, University of North Carolina, Chapel Hill, NC Learning Objective: Learn how to incorporate emergency medical system data into hospital information systems. JACC March 9, 2010 ABSTRACTS: Quality of Care and Outcomes Assessment A137

1139 EVALUATION OF RISK 1140 OUTCOMES IN THE ELDERLY Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1139-166 Characteristics of patients rehospitalized with Acute 1140-171 Acute Delirium Predicts Short-term Re- Decompensated Heart Failure (ADHF) within 30 hospitalization among Elderly patients Admitted days following discharge with Acutely Decompensated Heart Failure.

Sandip K. Zalawadiya, Hammam D. Zmily, Jareer O. Farah, Suleiman SHANMUGAM UTHAMALINGAM, Jagdesh Kandala, Marilyn Daley, Daifallah, Omaima A. Ali, Jalal K. Ghali, Wayne State University/ Robert Capodilupo, James L. Januzzi, New England Heart Institute Detroit Medical Center, Detroit, MI, John D.Dingell VA Medical at Catholic Medical Center, Manchester, NH, Division of Cardiology, Center, Detroit, MI Massachusetts General Hospital, Boston, MA Learning Objective: identify high risk ADHF patients at the time of Learning Objective: identify patients admitted with ADHF and acute admission the hospital for 30-day rehospitalization. delirium are at increased risk of new nursing home placement and to involve multidisciplinary team for effective discharge planning. 1139-167 Weighing the Evidence of Harm with PPI+ Clopidogrel verus Clopidogrel Alone for Secondary 1140-172 Post-MI Angina Status and Quality of Life in Older Prevention of CAD- Meta Analysis of Randomized vs. Younger Adults Trials and Observational Studies Comprising Over Ryan B. Longmore, John A. Spertus, Karen P. Alexander, Kimberly J. 50,000 Patients Reid, Phillip G. Jones, Harlan M. Krumholz, Frederick A. Masoudi, Abdul Hakeem, Sabha Bhatti, Kunal Karmali, Florence Rothenberg, Michael W. Rich, Mid-America Heart Institute, Kansas City, MO Robin H. Vandivier, University of Cincinnati College of Medicine, Learning Objective: Demonstrates the importance of angina Cincinnati, OH treatment after MI for both older and younger patients. Learning Objective: understand the clinical outcomes associated with Proton pump inhibitor use with clopidogrel 1140-173 Prevalence and Outcomes of Cognitive Impairment in Older Adult Survivors of Acute Myocardial 1139-168 Can Strain by Speckle Tracking Imaging Predict Infarction Mortality in Primary Amyloid Patients with Normal S. Michael Gharacholou, Kimberly J. Reid, Harlan M. Krumholz, Eric left Ventricle Ejection Fraction? D. Peterson, Karen P. Alexander, Mayo Clinic, Rochester, MN, Duke Haydar K. Saleh, Hector R. Villarraga, Diego Bellavia, Yang Yu, University, Durham, NC Yuki Koshino, Su-Feng Hsiao, Garvan C. Kane, Patricia A. Pellikka, Learning Objective: Demonstrate the prevalence of cognitive Fletcher A. Miller, Mayo Clinic, Rochester, MN impairment and its association with outcomes in older adult Learning Objective: Identify that in primary amyloid patients with survivors of acute myocardial infarction. normal LVEF, strain by speckle imaging is reduced and is a predictor of survival. 1140-174 Is Pre-diabetes Associated With Increased Mortality And Cardiovascular Morbidity In Community- 1139-169 Common Carotid Artery Intima Media Thickness dwelling Older Adults? Alone is Comparable to Carotid Intima Media Prakash C. Deedwania, Mustafa I. Ahmed, Marjan Mujib, Ali Thickness of all Carotid Artery Segments in Ahmed, V A Medical center, Birmingham, AL, University of Alabama, Improving Coronary Heart Disease Risk Prediction

Birmingham, AL Outcomes Assessment

in the Atherosclerosis Risk In Communities (ARIC) Quality of Care and Study Learning Objective: evaluate the prognostic impact of Pre diabetes on CV outcome in Older adults Vijay Nambi, Lloyd Chambless, Max He, Aaron R. Folsom, Tom Mosley, Eric Boerwinkle, Christie Ballantyne, Baylor College of Medicine, Houston, TX Learning Objective: understand how to use carotid intima media thickness in coronary heart disease risk prediction

1139-170 Relative Risk of Death from Cardiovascular Disease Robert J. Bryg, Tae Yang, David Bryg, Olive View-UCLA Medical Center, Sylmar, CA, UCLA, Los Angeles, CA Learning Objective: describe the difference in mortality in differerent cardiovascular disease states. A138 ABSTRACTS: Quality of Care and Outcomes Assessment JACC March 9, 2010

1141 QUALITY OF LIFE AND SOCIAL ISSUES 1142 GENDER AND OUTCOME Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1141-177 Leadership Qualities and Health Related Behaviors: 1142-183 Temporal Effect on Gender Differences in Patients Is There a Relationship? Undergoing Evaluation for Coronary Artery Disease

Elizabeth A. Jackson, Preeti Iyer, Jean E. DuRussel-Weston, Caren S. Monika Arora, Dina Sparano, Nils P. Johnson, Claire O’Connell, Goldberg, Bruce Rogers, LaVaughn Palma-Davis, Susan Aaronson, Thomas A. Holly, Martha Gulati, Northwestern Memorial Hospital, Catherine M. Fitzgerald, Marc Zimmerman, Lindsey R. Mitchell, Chicago, IL Roopa Gurm, Kim A. Eagle, University of Michigan Health Systems, Learning Objective: Assess temporal effect of gender on referral Ann Arbor, MI to angiography after abnormal myocardial perfusion imaging and Learning Objective: Describe the potential relationship between survival. leadership qualities and health related behaviors. 1142-184 Gender Differences in the Incidence of All Cause 1141-178 Coronary Atherosclerosis, Posttraumatic Stress Mortality Disorder and Mortality incidence Naser Ahmadi, Fereshteh Hajsadeghi, Hormoz B. Mirshkarlo, Naser Ahmadi, Hormoz B. Mirshkarlo, Fereshteh Hajsadeghi, Matthew Budoff, Ramin Ebrahimi, Los Angeles Biomedical Research Matthew Budoff, Ramin Ebrahimi, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA Institute at Harbor UCLA Medical Center, Torrance, CA Learning Objective: This study point to an increasing incidence Learning Objective: Post-traumatic Stress Disorder (PTSD) is of mortality in both men and women with increasing CAC scores. associated with increased subclinical atherosclerosis and In addition, for age and CAC adjusted groups, men had higher predicts poor cardiovascular outcome independent of conventional mortality rates than women cardiovascular risk factors 1142-185 Gender Difference in Novel Biomarkers for 1141-179 Feasibility of Routine Quality of Life Assessment in Predicting Future Cardiovascular and Coronary an Ambulatory Heart Failure Clinic and Impact of Events. Patient Perceptions on Health Status Vikas Veeranna, Ashutosh Niraj, Sandip Zalawadiya, Jyotiranjan Sabrina Badloe, Parakash Pratibhu, Lynne W. Stevenson, Akshay Pradhan, Luis Afonso, Wayne State University, Detroit, MI Desai, Michelle A. Young, Joanne R. Weintraub, Michael M. Givertz, Learning Objective: Gender specific use of novel cardiovascular risk Eldrin F. Lewis, Brigham and Women’s Hospital, Boston, MA factors in cardiovascular risk assessment. Learning Objective: To evaluate the role of quality of life assessment in heart failure management 1142-186 Sex Differences in Outpatient Performance Measures: A Report of the first 14,000+ Patients in 1141-180 Has the U.S. Stock Market Collapse Impacted the American College of Cardiology’s IC3 (Improving Cardiovascular Event Rates? Continuous Cardiac Care) Program

Mona Fiuzat, G. Michael Felker, Linda Shaw, Renato Lopes, Paul Chan, Donna Buchanan, Fran F. Fiocchi, Philip G. Jones, Kristi Christopher O’Connor, Duke University Medical Center, Durham, NC, Mitchell, Tracie Breeding, William J. Oetgen, John S. Rumsfeld, Duke Clinical Research Institute, Durham, NC John A. Spertus, Mid America Heart Institute, Kansas City, MO, The Learning Objective: To examine potential patterns between stressful American College of Cardiology, Washington DC events and CV event rates Learning Objective: Describe sex differences in rates of compliance with outpatient cardiovascular performance measures. 1141-181 Inappropriate Clopidogrel Adherence In Insured Minority Populations And Its Impact In Stent 1142-187 Impact of Anemia in Men and Women with ST- Related Outcomes. Segment Elevation Myocardial Infarction: The HORIZONS-AMI Trial Ana Palacio, Mark Gilbert, Leonardo Tamariz, Hua Li, Mauro

Quality of Care and Moscucci, Olveen Carrasquillo, University of Miami, Miami, FL Kenichi Tsujita, Eugenia Nikolsky, Alexandra J. Lansky, Louise Outcomes Assessment Learning Objective: Describe the effects of clopidogrel adherence by Gambone, Lynn Vandertie, Adriano Caixeta, George Dangas, Bruce ethnicity R. Brodie, Dariusz Dudek, Martin Möckel, Andrzej Ochala, Roxana Mehran, Gregg W. Stone, Columbia University Medical Center and the Cardiovascular Research Foundation, New York, NY Learning Objective: identify the difference of impact of anemia between men and women with STEMI JACC March 9, 2010 ABSTRACTS: Quality of Care and Outcomes Assessment A139

1192 SAFETY 1193 OUTCOMES ASSESSMENT IN HEART FAILURE I Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1

1192-154 Risk of Upper Gastrointestinal Bleeding among Users 1193-160 Changes in Incidence and Mortality Rates of of Clopidogrel and Low-dose Acetylsalicylic Acid Ischemic and Non-Ischemic Heart Failure. A 10-Year Study Luis Alberto Garcia Rodriguez, Saga Johansson, Spanish Centre for Pharmacoepidemiological Research (CEIFE), Madrid, Spain, Yingzi Deng, Abel E. Moreyra, William J. Kostis, John Pantazopoulos, AstraZeneca R&D, Mölndal, Sweden Nora M. Cosgrove, Alan C. Wilson, John B. Kostis, for the MIDAS group, UMDNJ-Robert Wood Johnson Medical School, New Learning Objective: quantify the risk of upper gastrointestinal Brunswick, NJ bleeding associated with low-dose acetylsalicylic acid and concomitant clopidogrel, and understand how use of proton pump Learning Objective: To study recent trends in incidence and inhibitors can reduce this risk outcomes of heart failure due to ischemic and non-ischemic etiologies. 1192-155 In-Hospital Hemodialysis and Mortality Rates in Individuals Undergoing Invasive Cardiac 1193-161 Gain in Life Expectancy in Patients with Left Catheterization Procedures with Low Osmolar Ventricular Systolic Dysfunction Treated Early with Contrast Agents: A Multicenter Study of 207,826 Enalapril: A 23-Year Follow-Up of SOLVD Cohort in Patients Belgium

James Min, Amy Ryan, Fay Y. Lin, Teresa David, Weill Cornell Medical Michel F. Rousseau, Philip Jong, Sylvie A. Ahn, University of Louvain, College, New York, NY, Premier, Inc., Charlotte, NC Brussels, Belgium, University of Toronto, Toronto, ON, Canada Learning Objective: To understand adverse events following low Learning Objective: to demonstrate gain in life expectancy in osmolar contrast media exposure in inpatients undergoing cardiac patients with left ventricular systolic dysfunction treated early with catheterization procedures enalapril

1192-156 Cumulative Exposure to Ionizing Radiation from 1193-162 Predictive Model For Six-month Risk Of Death Or Cardiac Imaging Procedures Hospitalization In Ambulatory Heart Failure Patients

Jersey Chen, Harlan M. Krumholz, Yongfei Wang, Joseph Ross, Reza Scott Hummel, Todd M. Koelling, University of Michigan, Ann Arbor, MI Fazel, Henry Ting, Nilay Shah, James Brink, Khurram Nasir, Andrew Learning Objective: Risk-stratify ambulatory heart failure patients for J. Einstein, Brahmajee K. Nallamouthu, Yale University School of death and/or hospitalization Medicine, New Haven, CT, University of Michigan, Ann Arbor, MI

Learning Objective: Understand cumulative radiation dose from 1193-163 Trends in Incident Hospitalizations, Management, cardiac imaging procedures and Outcomes of Heart Failure in Ontario, Canada: 1995 to 2007 1192-157 The American College of Cardiology’s IC3 (Improving Continuous Cardiac Care) Program and Darwin F. Yeung, Nicole K. Boom, Douglas S. Lee, Jack V. Tu, Heart Failure Performance Measures: A Report of Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, the first 14,000+ Patients University of Toronto, Toronto, ON, Canada Learning Objective: To identify trends in incident hospitalization,

Paul Chan, Donna Buchanan, Fran F. Fiocchi, Fengming Tang, Kristi Outcomes Assessment

management, and outcomes of heart failure in Ontario, Canada. Quality of Care and Mitchell, Duane Thrutchley, William J. Oetgen, John S. Rumsfeld, John A. Spertus, Mid America Heart Institute, Kansas City, MO, The Can Serial Measurement of B-type Natriuretic American College of Cardiology, Washington DC, DC 1193-164 Peptide Levels Provide Incremental Prognostic Learning Objective: Describe insights into outpatient heart failure Information in Ambulatory Patients with Chronic quality of care. Heart Failure?

1192-158 Congestive Heart Failure Performance Measures: Leonardo P. j. Oliveira, Esteban Walker, W.H. Wilson Tang, Cleveland Does Adherence Impact Early Unplanned Hospital Clinic Foundation, Cleveland, OH, OH Readmissions? Learning Objective: Identify that serial BNP measurements has prognostic value in chronic heart failure patients. Sula Mazimba, Nakash Grant, Diklar Makola, Jessica Tan, Lata Parvathaneni, Trupti Patel, Vikas Kalra, Radha Kothapalli, Christina Redko, Harvey Hahn, Kettering Medical Center, Kettering, OH, Wright State University Boonshoft School of Medicine, Dayton, OH Learning Objective: Identify factors responsible for unplanned early readmssions for Congestive Heart failure A140 ABSTRACTS: Quality of Care and Outcomes Assessment JACC March 9, 2010

1194 OUTCOMES, HYPERTENSION AND KIDNEY 1195 COMPARATIVE EFFECTIVENESS STUDIES DISEASE Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1 1195-172 Net Clinical Benefit of Combination Anticoagulant 1194-166 Serum Cystatin C Levels and Long-Term Mortality and Antiplatelet Therapy versus Anticoagulation among Subjects with Normal Creatinine-Based alone in Atrial Fibrillation patients: Results from the Estimated Glomerular Filtration Rates AMADEUS trial

Jou-Wei Lin, Cho-Kai Wu, Yu-Sheng Lin, Dept of Environmental and Deirdre Lane, Pieter Kamphuisen, Pascal Minini, Olaf R. De Peuter, Occupational Health, Univ of North Texas Health, Fort Worth, TX, Harry R. Buller, Gregory Y H Lip, University of Birmingham Centre National Taiwan University Hospital Yun-Lin Branch, Dou-Liou City, for Cardiovascular Sciences, City Hospital, Birmingham, United Yun-Lin County, Taiwan,ROC Kingdom, Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands Learning Objective: Cystatin C is prognostic of long-term outcome. Learning Objective: Combination antithrombotic therapy increases 1194-167 Sudden Cardiac Death in Relation to Changing the risk of clinically relevant bleeding in AF patients and does not Heart Rate During Treatment of Hypertension: The reduce the risk of stroke. LIFE Study 1195-173 Aspirin Therapy for Primary versus Secondary Peter M. Okin, Darcy A. Hille, Sverre E. Kjeldsen, Stevo Julius, Björn Prevention of Cardiovascular Disease: An Updated Dahlöf, Richard B. Devereux, Weill Cornell Medical College, New York, NY Meta-Analysis.

Learning Objective: Describe the relationship of sudden cardiac Jayanta Robert Das, Shervin Eshaghian, George A. Diamond, P.K. death to heart rate Shah, Sanjay Kaul, Cedars Sinai Medical Center, Los Angeles, CA

1194-168 Left Ventricular Mass Index Predicts Renal Learning Objective: Evaluate the benefit-risk balance for aspirin in Outcomes in High Vascular Risk men: a 3-year primary versus secondary prevention of cardiovascular disease. Follow-up Study 1195-174 Comparison of Everolimus-Eluting and Paclitaxel- Konstantinos P. Tsioufis, C. Thomopoulos, P. Kokkinos, C. Faselis, M. Eluting Coronary Stents in Patients Undergoing Doumas, D. Papadopoulos, N. Kukar, R. Amdur, V. Papademetriou, Multi-Vessel Stenting: Pooled Analysis from the Veterans Administration and Georgetown University Medical SPIRIT III and SPIRIT IV Randomized Trials Centers, Washington DC, WA, Greece Dean J. Kereiakes, Krishnankutty Sudhir, James B. Hermiller, Learning Objective: identify the predictive value of LVMI on Alexandra J. Lansky, Julie Doostzadeh, Wesley Pierson, Xiaolu kidney dysfunction plus incident dialysis despite optimal ongoing Su, Paul C. Gordon, Gregg W. Stone, The Christ Hospital Heart & vasoactive treatment accompanied by significant BP lowering within Vascular Ctr/The Lindner Research Ctr, Cincinnati, OH non-hypertensive levels Learning Objective: Evaluate the performance of XIENCE V 1194-169 Impact of Dialysis-Dependent End Stage Renal everolimus-eluting stents in patients undergoing multi-vessel Disease and Advanced Chronic Kidney Disease stenting in a large pooled analysis of the SPIRIT III and IV trials on In-Hospital Outcomes in Patients Undergoing Percutaneous Coronary Intervention 1195-175 Performance Measures for In-Hospital Management of Acute Coronary Syndromes in Europe Puja Parikh, Luis Gruberg, Allen Jeremias, Srihari S. Naidu, Richard A. Shlofmitz, Sorin J. Brenner, Thomas Pappas, Kevin P. Marzo, David francois schiele, Matthias Hochadel, Marco Tubaro, Keith L. Brown, Stony Brook University Medical Center, Stony Brook, NY, A.A. Fox, Jean-Pierre Bassand, Anselm Gitt, Nicolas Danchin, Winthrop University Hospital, Mineola, NY University Hospital Jean Minjoz, Besancon, France, Institut für Herzinfarktforschung, Ludwigshafen, Germany Learning Objective: determine if dialysis-dependent end stage renal disease and advanced chronic kidney disease are predictive Learning Objective: describe the use of performance measures in of adverse cardiac events in patients undergoing percutaneous the management of ACS in Europe coronary intervention Quality of Care and Outcomes Assessment 1194-170 Does the Presence of Microalbuminuria Portend a Worse Outcome in Non-Diabetic Patients with Metabolic Syndrome?

Pawan K. Hari, Vikas Veeranna, Rajeev Sudhakar, Palaniappan Manickam, Ramanjit Kaur, Jyotiranjan Pradhan, Sony Jacob, Luis Afonso, Wayne State University, Detroit, MI Learning Objective: Identify that Microalbuminuria in non-diabetic patients with metabolic syndrome predicts higher cardiovascular morbidity and all cause mortality compared to metabolic syndrome alone JACC March 9, 2010 ABSTRACTS: Quality of Care and Outcomes Assessment A141

1196 OUTCOMES ASSESSMENT IN HEART FAILURE II 1197 OBESITY AND DIET Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1

1196-177 Association of Heart Failure Beliefs and Self-Care 1197-183 Waist Hip Ratio, not Body Mass Index Predicted Adherence in Patients Treated in an Emergency Cardiovascular Risk in a Multi Ethnic Cohort of Department for Acute Decompensated Heart Healthy Adults. Failure Sandip K. Zalawadiya, Jyotiranjan Pradhan, Ashutosh Niraj, Vikas Nancy M. Albert, Phillip Levy, Elizabeth Langlois, Benjamin Nutter, Veerana, Palaniappan Manickam, Pavan Hari, Jacob Sony, Luis Dongsheng Yang, Vijaya Arun Kumar, Patrick Medado, Elizabeth Afonso, Wayne State University/Detroit Medical Center, Detroit, MI Nykun, Cleveland Clinic, Cleveland, OH, Wayne State University, Learning Objective: utilize waist-hip ratio for prediction of future Detroit, MI cardivascular events accross different ethinic strata. Learning Objective: Evaluate the association between heart failure illness beliefs and self-care in acutely decompensated patients 1197-184 Cardiac Outcomes after Screening for treated in an emergency care setting Asymptomatic Coronary Artery Disease in Patients with Metabolic Syndrome: Post-Hoc Analysis of the 1196-178 Coexistence of Multiple Cardiovascular Disease DIAD Trial is a Independent Predictor of 30-day Mortality in Hospitalized Patients with Congestive Heart Failure: Shanti Bansal, Frans J. Th. Wackers, Silvio Inzucchi, Lawrence H. Young, A Study in Beijing M.D., Deborah A. Chyun, Yale-New Haven Hospital, New Haven, CT Learning Objective: Utility of screening myocardial perfusion imaging Yusheng Zhao, Qiao Xue, Xingli Wu, Lei Gao, Jiayue Li, Ping He, Mei in metabolic syndrome patients Zhu, Shiwen Wang, Chinese PLA General Hospital, Beijing, People’s Republic of China 1197-185 Effects on Mortality and Morbidity in Overweight/ Learning Objective: to identify the risk stratification in the patient Obese Subjects: The Sibutramine Cardiovascular with congestive heart failure Outcomes (SCOUT) Trial

1196-179 Heart Failure with Preserved Ejection Fraction: Philip James, Ian Caterson, Walmir Coutinho, Nick Finer, Luc Van Mortality Risk Post First Hospitalization - Data from Gaal, Aldo Maggioni, Arya M. Sharma, Christian Torp-Pedersen, The I-PRESERVE SCOUT Team, Abbott Laboratories, Abbott Park, IL Learning Objective: To assess whether weight management with Peter E. Carson, Michael Zile, John McMurray, Robert McKelvie, sibutramine together with standard care for weight management will Michel Komajda, Scott Hetzel, David DeMets, Christoph Staiger, reduce cardiovascular morbidity and mortality in high-risk subjects Agata Ptaszynska, Barry Massie, Department of Veterans Affairs to a greater extent than Medical Center, Washington, DC, DC, Georgetown University, Washington, DC 1197-186 Association between Vitamin D Deficiency and Learning Objective: assess mortality risk in HF-PEF Prevalence of Cardiovascular Disease

Tami Bair, Nathaniel L. Hall, Heidi T. May, Jeffrey L. Anderson, 1196-180 The Impact of a Mental Health Related Diagnosis on Readmission Rates for Congestive Heart Failure Benjamin D. Horne, John F. Carlquist, Donald L. Lappé, Joseph B. Muhlestein, Intermountain Medical Center, Murray, UT

Ronald S. Freudenberger, Carol A. Foltz, Lou Lukas, Donna F. Outcomes Assessment

Learning Objective: Examine the relationship between Vitamin D Quality of Care and Petruccelli, Hannah Paxton, Victoria Sabella, Lehigh Valley Health and the risk of cardiovascular disease. Network, Allentown, PA Learning Objective: Identify the impact of mental illness on readmission rates for patietns with heart failure 1247 QUALITY OF CARE - DISPARITIES Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Predictive Value of Ejection Fraction and Renal 1196-181 Georgia World Congress Center, Hall B5 Function in High Risk Acute Coronary Syndrome Presentation Hour: 9:30 a.m. - 10:30 a.m. Patients: Results from the SYNERGY Trial CME/CE Hours: 1 Melvin R. Echols, Micheal C. Kontos, Kristi Prather, Douglas D. Schocken, Stuart D. Russell, Judith S. Hochman, Luigi Biasucci, 1247-154 Prevalence of Vaccination in Systolic Heart Failure: John French, Kenneth Mahaffey, Duke Clinical Research Institute, A Prospective Study of 549 Patients by Race/ Durham, NC, Duke University Health System, Durham, NC Ethnicity and Gender. Learning Objective: Understand the effect of renal function and George R. Marzouka, Elyse Julian, Frank B. Cortazar, Andre Dias, heart failure in older patients with ACS Leonardo Tamariz, Kathy Hebert, University of Miami, Miami, FL, Jackson Memorial Hospital, Miami, FL Learning Objective: Identify factors that influence vaccination in heart failure patients A142 ABSTRACTS: Quality of Care and Outcomes Assessment JACC March 9, 2010

1247-155 Does Obesity Account for Gender and Race 1248-161 The Changing Definition Of Contrast Induced Disparity for Subsequent Cardiac Catheterization in Nephropathy And Its Clinical Implications: Insights Patients Having Undergone Stress Testing? From The Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) Wael ElMallah, Douglas Einstadter, Robert S. Finkelhor, Case Western Reserve University / MetroHealth Medical Center, Nicklaus Slocum, Mauro Moscucci, Dean Smith, Herb Aronow, Cleveland, OH Simon Dixon, David Share, Hitinder S. Gurm, University of Michigan Medical Center, Ann Arbor, MI Learning Objective: Describe the characteristics of patient referral to cardiac catheterization Learning Objective: Describe differences in CIN definitions and its clinical implications 1247-156 Equitable Improvement for Women and Men in the Use of Guideline-Recommended Therapies for Heart 1248-162 Patient and Cardiologists’ Perceptions of the Failure: Findings from IMPROVE HF Benefits of PCI for Stable Coronary Disease

Mary Norine Walsh, Gregg C. Fonarow, Nancy M. Albert, Anne Senthil Sivalingam, Michael Rothberg, Javed Asharf, Paul Visintainer, B. Curtis, Wendy Gattis Stough, Mihai Gheorghiade, J Thomas John Joelson, Reva Kleppel, Neelima Vallurupalli, Marc Schweiger, Heywood, Mark L. McBride, Christopher M. O’Connor, Patches Baystate Medical Center, Springfield, MA Johnson Inge, Mandeep R. Mehra, Dwight Reynolds, Clyde W. Yancy, Learning Objective: Recognize the difference in expectation between Medtronic, Inc., Minneapolis, MN patient and cardiologist before elective PCI for stable angina Learning Objective: To identify differences and similarities between the sexes in use of guideline-recommended therapies for HF in 1248-163 Diminishing Racial Disparities in the Utilization of the outpatient setting following a practiced-based performance Drug-Eluting Stents Among Medicare Beneficaries: improvement intervention. 2003-2004

1247-157 Potential Impact of Poor Patient Education Jerome Federspiel, Sally C. Stearns, Laura P. D’Arcy, Kristin L. Reiter, Materials on Cardiovascular Outcomes Brett C. Sheridan, Joseph S. Rossi, UNC School of Public Health, Chapel Hill, NC, UNC School of Medicine, Chapel Hill, NC Clare Murphy, Madeline Keyes, Kimberli Taylor-Clarke, Andre L. Churchwell, Alfred S. Callahan, Henry Okafor, Russell Rothman, Learning Objective: Describe how the the impact of patient race on Douglas Sawyer, Uchechukwu K. Sampson, Vanderbilt University the decision to use DES changed as DES became more common. Medical Center, Nashville, TN 1248-164 Trends In Cardiac Rehabilitation Referral Rates Learning Objective: Importance of attention to patient literacy levels For Patients Undergoing Percutaneous Coronary in health care delivery Intervention: Insights From The BMC2 Registry

1247-158 Racial Differences in the Attainment of Krishna G. Aragam, Mauro Moscucci, David Share, Dean E. Smith, Cardiovascular Risk Factor Goals Among Insured Hitinder S. Gurm, University of Michigan Medical Center, Ann Arbor, MI Adults with Diabetes Mellitus Learning Objective: Evaluate the prevalence and predictors of Abhinav Goyal, Tracy N. Thomas, Joshua Barzilay, Robert L. Davis, Cardiac Rehab referrals for patients undergoing PCI Viola Vaccarino, Peter W. F. Wilson, Emory University Schools of Public Health and Medicine, Atlanta, GA, The Center for Health 1249 QUALITY OF CARE - PERFORMANCE MEASURES Research, Kaiser Permanente Georgia, Atlanta, GA Learning Objective: To describe how rates of achieving Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. recommended cardiovascular risk factor goals differ between Georgia World Congress Center, Hall B5 medically insured African-American and Caucasian adults with Presentation Hour: 9:30 a.m. - 10:30 a.m. diabetes mellitus. CME/CE Hours: 1

Comparison of Hospital Performance of Acute 1248 QUALITY OF CARE - PCI 1249-166 Myocardial Infarction and Heart Failure Quality Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Measures: Findings from the Get With The Georgia World Congress Center, Hall B5 Guidelines Registry Presentation Hour: 9:30 a.m. - 10:30 a.m. Tracy Wang, David Dai, Adrian Hernandez, Deepak Bhatt, Paul CME/CE Hours: 1 Quality of Care and Heidenreich, Gregg Fonarow, Eric Peterson, Duke Clinical Research Outcomes Assessment Institute, Durham, NC Comparison of Radiation Dose in Femoral and 1248-160 Learning Objective: Describe the correlation between hospital Radial Arterial Access Coronary Procedures; the performance of AMI and HF quality measures Effect of Operator Experience.

Johanne Neill, Hannah Douglas, Niall Herity, Belfast City Hospital, Belfast, United Kingdom Learning Objective: appreciate that whilst radial access coronary procedures are associated with fewer acces site complications, there is greater radiation dose than with femoral access. JACC March 9, 2010 ABSTRACTS: Quality of Care and Outcomes Assessment A143

1249-167 Temporal Trends In The Management Of Severe 1250-173 Missed Opportunities in the Management of ST Hyperglycemia Among Patients Hospitalized With Segment Elevation Myocardial Infarction in the Arab Acute Myocardial Infarction Middle East: Patients and Physicians Impediments

Lakshmi VENKITACHALAM, Kensey Riley, Kasia Lipska, Silvio E. Mouaz H. Al-Mallah, Alawi A. Alsheikh-Ali, Wael Almahmeed, Kadhim Inzucchi, Abhinav Goyal, John A. Spertus, Frederick A. Masoudi, Sulaiman, Jassim Al Suwaidi, Mustafa Ridha, Ahmed Al-Motarreb, Philip G. Jones, Mikhail Kosiborod, Saint Luke’s Mid America Heart Fahad Alenezi, Mohammad Zubaid, Henry Ford Hospital, Detroit, MI Institute, Kansas City, MO Learning Objective: to undertsand the indpendent predictor of lack Learning Objective: Understand the temporal trends in managment of reperfusion therpay in the arab middle east. of severe sustained hyperglyemia in acute myocardial infarction patients 1250-174 Time Trends in PCI and CABG Rates in Acute Myocardial Infarction Patients with Cardiogenic In-Hospital Hemoglobin A Testing and Its Relation 1249-168 1c Shock to Initiation of Glucose Lowering Therapy in Hyperglycemic Patients with Acute Myocardial Khung Keong Yeo, Beate Danielsen, Patrick Romano, Richard White, Infarction Ezra A. Amsterdam, Zhongmin Li, University of California, Davis Medical Center, Sacramento, CA Joshua Stolker, John A. Spertus, Darren K. McGuire, Silvio E. Learning Objective: To describe the time trends in CABG and PCI Inzucchi, Saif S. Rathore, Thomas M. Maddox, Frederick A. Masoudi, procedures performed in California from 1997 to 2008 in patients Fengming Tang, Philip G. Jones, Mikhail Kosiborod, St Luke’s Mid wth AMI and cardiogenic shock America Heart Institute, Kansas City, MO Learning Objective: Evaluate the relationship between in-hospital 1250-175 Patterns and Predictors of Fast Food Consumption A1C measurement and new antihyperglycemic therapy. after Acute Myocardial Infarction

Adam C. Salisbury, Paul S. Chan, Kensey L. Riley, Donna M. 1249-169 Improving Perioperative Cardiac Risk Assessment and Beta-Blocker Use for Non-Cardiac Surgery Buchanan, Alpesh Amin, John A. Spertus, Mid-America Heart Institute/University of Missouri-Kansas City, Kansas City, MO (INCREASE): The INCREASE Quality Improvement Project Learning Objective: Describe the prevalence and correlates of frequent fast food intake after acute myocardial infarction. Anitha Rajamanickam, Ali Usmani, Eric Hixson, Prabhakaran Anbazhagan, Anuradha Ramaswamy, Mike Pecic, Amir Jaffer, Brian Harte, Cleveland Clinic, Cleveland, OH 1251 QUALITY OF CARE - READMISSIONS Learning Objective: To determine whether referral to a standardized Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. preoperative evaluation clinic increased the likelihood of Georgia World Congress Center, Hall B5 administration of PBB Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1250 QUALITY OF CARE - ACUTE MYOCARDIAL INFARCTION 1251-177 Prevalence, Correlates and Inter-hospital Variation of Early Outpatient Follow-up after Acute Myocardial Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Infarction Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Adam C. Salisbury, Kevin F. Kennedy, John A. Spertus, Stacie L. Daugherty, Frederick A. Masoudi, Joseph S. Ross, Karen P. CME/CE Hours: 1 Alexander, Harlan M. Krumholz, Mid-America Heart Institute/ University of Missouri-Kansas City, Kansas City, MO, Yale University,

1250-171 System Delay as a Predictor of Mortality in Acute New Haven, CT Outcomes Assessment Myocardial Infarction - A DANAMI-2 Substudy Quality of Care and Learning Objective: Describe the prevalence, correlates, and Michael Maeng, Peter H. Nielsen, Christian J. Terkelsen, Henning R. inter-hospital variation of early outpatient follow-up after acute Andersen, Aarhus University Hospital, Skejby, Aarhus, Denmark myocardial infarction. Learning Objective: describe the impact of system delay on mortality after acute myocardial infarction 1251-178 Which Hospitals Have Higher Readmission Rates for Patients with Heart Failure?

1250-172 Early Invasive vs. Conservative Treatment in Non-ST- Karen Joynt, Ashish K. Jha, Brigham and Women’s Hospital, Boston, Segment Myocardial Infarction: Evidence for a Risk MA, Harvard School of Public Health, Boston, MA Treatment Paradox? Learning Objective: describe characteristics of hospitals that have Kim Smolderen, Paul S. Chan, Kensey Riley, Phil G. Jones, Donna M. higher than average 30day readmission rates for HF, and describe Buchanan, Johan Denollet, Saket Girotra, Harlan M. Krumholz, John the policy implications of these findings. A. Spertus, Tilburg University, Tilburg, The Netherlands, Mid America Heart Institute, Kansas City, MO Learning Objective: To understand that AMI patients with the highest disease burden, are less likely to be referred for early invasive treatment than patients with an excellent quality of life. A144 ABSTRACTS: Quality of Care and Outcomes Assessment JACC March 9, 2010

1251-179 Factors Leading to 30 Day Readmission Following 1252-185 Racial Differences in Outpatient Performance Hospitalization for Heart Failure Measures: A Report of the first 10,000+ Patients in the American College of Cardiology’s IC3 (Improving Jalal K. Ghali, Hammam D. Zmily, Ibrahim Shaik, Jareer O. Farah, Continuous Cardiac Care) Program Suleiman Daifallah, Ramanjit Kaur, Omaima A. Ali, Husam Al Samarah, Phillip Levy, S. William Tam, Michelle Schreiber, Detroit Paul Chan, Donna Buchanan, Fran F. Fiocchi, Philip G. Jones, Kristi Medical Center/Wayne State University, Detroit, MI, John D. Dingell Mitchell, Duane Thrutchley, William J. Oetgen, John S. Rumsfeld, VA Medical Center, Detroit, MI John A. Spertus, Mid America Heart Institute, Kansas City, MO, The Learning Objective: Understand the factors that lead to early American College of Cardiology, Washington DC, DC readmission for patients with HF in order to avoid or decrease early Learning Objective: Describe racial differences in rates of readmission and allow for a smooth transition from in-patient to compliance to outpatient cardiovascular performance measures. outpatient follow up. 1252-186 Racial and Ethnic Minorities in California Are More 1251-180 Bridging the Gap Between Discharge and Follow-up: Likely to be Treated by Cardiac Surgeons with Initial Report on a Cardiology Bridge Clinic Higher Operative Mortality Rates

Eva Kline-Rogers, Adam Leidal, Susan Housholder-Hughes, Lynette Luis Castellanos, Zhongmin Li, Khung K. Yeo, J. Nilas Young, Mollo, Cheryl Bord, Julie Merz, Janice Norville, Danielle Stahlbaum, Ezra Amsterdam, University of California, Davis Medical Center, Elise Woznicki, Jeannette Figurel, Kim A. Eagle, Elizabeth A. Sacramento, CA Jackson, Melvyn Rubenfire, University of Michigan, Ann Arbor, MI Learning Objective: Identify racial and ethnic disparties in access to Learning Objective: Identify one way to improve timely follow-up care high performing cardiac surgeons for patients recently discharged from the hospital 1252-187 The New Jersey Study of the “Hispanic Paradox” 1251-181 Quality of Care for Comorbid Conditions in Heart Failure with Normal Ejection Fraction Jacob M. Mathew, Abel E. Moreyra, Yingzi Deng, Nora M. Cosgrove, Alan C. Wilson, John Pantazopoulos, John B. Kostis, The MIDAS Scott Hummel, Amar Kommuri, Todd M. Koelling, University of Study Group, UMDNJ- Robert Wood Johnson Medical School, New Michigan, Ann Arbor, MI, Sinai Grace Hospital/Detroit Medical Brunswick, NJ Center, Detroit, MI Learning Objective: realize racial disparities in health care which Learning Objective: describe quality of care for comorbid conditions can be minimized by better decisions by policy makers in HF-NEF

1252 QUALITY OF CARE - DISPARITIES Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1

1252-183 Low Acculturation Predicts Rehospitalization among Underserved Patients with Heart Failure

Pamela N. Peterson, Elizabeth Campagna, L. Miriam Dickinson, Moises Maravi, Larry A. Allen, Frederick A. Masoudi, Denver Health Medical Center, Denver, CO, University of Colorado, Denver, Aurora, CO Learning Objective: Evaluate the association between acculturation and rehospitalization among underserved patients with heart failure

1252-184 Financial Barriers to Care and Outcomes after Acute Myocardial Infarction: Does age matter?

Joseph S. Ross, Erica Spatz, Kimberly Reid, Paul Chan, Susannah Quality of Care and Bernheim, Judith Lichtman, John Spertus, Harlan Krumholz, Mount Outcomes Assessment Sinai School of Medicine, New York, NY Learning Objective: Describe Age Variation in Outcomes After AMI Among Adults With Financial Barriers to Care JACC March 9, 2010 ABSTRACTS: Valvular Heart Disease A145 Valvular Disease Heart ORAL CONTRIBUTIONS

901 HOT TOPICS: AORTIC VALVE 902 HOT TOPICS: MITRAL VALVE Sunday, March 14, 2010, 2:00 p.m. - 3:30 p.m. Sunday, March 14, 2010, 4:30 p.m. - 6:00 p.m. Georgia World Congress Center, Room B408 Georgia World Congress Center, Room B408 CME/CE Hours: 1.5 CME/CE Hours: 1.5

2:00 Survival and Predictors of Mortality in Elderly 4:30 Analysis of 1000 Consecutive Cases of Mitral Valve Unoperated Patients with Severe Aortic Stenosis Repair Cases with Dynamic Annular Sizing and No Leaflet Resection M. Fuad Jan, Satish Velagapudi, Naoyo Mori, Brian Janosik, Kiran Sagar, Aurora Cardiovasc Svcs, Aurora Sinai/St. Luke’s Med Gerald M. Lawrie, Elizabeth Earle, Nan Earle, The Methodist Ctrs, Univ Wisconsin Sch Med & Public Health-MCC, Milwaukee, DeBakey Heart Institute, Houston, TX WI, Center for Urban Population Health, University of Wisconsin- Milwaukee, Milwaukee, WI Learning Objective: evaluate the early and late results of a non- resectional dynamic mitral valve repair technique. Learning Objective: better identify predictors of mortality in the elderly population with symptomatic severe aortic stenosis. 5:00 Late Survival, Clinical and Echocardiographic Outcomes after Mitral Valve Repair in Patients with 2:15 Factors Affecting Management Decisions in Severe Impaired Ventricular Function Aortic Stenosis Patients with Class I Indications for Aortic Valve Replacement Eugene A. Grossi, Leora B. Balsam, Gregory H. Crooke, Charles Schwartz, David G. Greenhouse, Patricia A. Ursommano, Margaret Aman Dua, Patricia Dang, Rimon Shaker, Padmini Varadarajan, Ramdas Mirabella, Alfred T. Culliford, M.D., Greg H. Ribakove, Aubrey C. G. Pai, Loma Linda University Medical Center, Loma Linda, CA Galloway, New York University Medical Center, New York, NY Learning Objective: Learn that patients with severe AS are not Learning Objective: Describe the predictors of late survival following referred for AVR despite class 1 indications mitral valve repair in patients with decreased ventricular function.

2:30 Early Hemodynamic and Neurohormonal Response 5:15 Is There Benefit in Performing Mitral Valve Repair in after Percutaneous Versus Surgical Aortic Valve Patients with Severe Left Ventricular Dysfunction? Replacement Vaughn A. Starnes, Mark J. Cunningham, Joshua Chan, Becky M. Mohammad A. Sherif, Mohamed Abdel-Wahab, Volker Geist, Joerg Lopez, University of Southern California Keck School of Medicine, Kynast, Reinhard Semmler, Ralph Tölg, Gert Richardt, Segeberger Los Angeles, CA Kliniken GmbH, Bad Segeberg, Germany Learning Objective: Distinguish which patients are appropriate as Learning Objective: describe the hemodynamic and neurohormonal surgical candidates who suffer from left ventricular dysfunction and response after percutaneous and surgical aortic valve reolacement MR.

2:45 Transcatheter Aortic Valve Implantation: Single 5:30 Early and Midterm Outcomes of Mitral Repair Are Centre Outcomes from the First 250 High-Risk Superior to Mitral Replacement in Octogenarians Patients Joanna Chikwe, Jurgen Passage, Anelechi Anyanwu, Andrew B. Ronen Gurvitch, Fabian Nietlispach, Anson Cheung, Jian Ye, David A. Goldstone, Javier G. Castillo, Federico Milla, Jurgen Seeburger, Wood, Namal Wijesinghe, Edgar L. Tay, Chris R. Thompson, Samuel Friedrich Mohr, David H. Adams, Mount Sinai Medical Center, New Lichtenstein, John G. Webb, St. Paul’s hospital, Vancouver, BC, York, NY, Leipzig Heart Center, Leipzig, Germany Canada Learning Objective: Describe the outcomes of mitral valve repair Learning Objective: appreciate the learning curve associated with compard to replacement in octogenarian patients transcatheter aortic valve implantation 5:45 Outcomes of the Randomized Evaluation of a 3:00 Midterm Benefits of Perioperative Statin Therapy Surgical Treatment for Off-Pump Repair of the in Patients Undergoing Isolated Valvular Heart Mitral Valve (RESTOR-MV) Trial Surgery: Five-Year Surgical Experience Eugene A. Grossi, Nirav Patel, Y Joseph Woo, Judith Goldberg, Muthiah Vaduganathan, Neil J. Stone, Satvik Ramakrishna, Eli I. Charles Schwartz, Valavanur A. Subramanian, Ted Feldman, Lev, Richard Lee, Edwin C. McGee, Jr., S. C. Malaisrie, Robert A. Robert C. Bourge, Norman Baumgartner, Christopher Genco, Scott Silverberg, Patrick M. McCarthy, Bluhm Cardiovascular Institute, Goldman, Marco A. Zenati, J Alan Wolfe, Yugal K. Mishra, Naresh Northwestern University Feinberg School of Medicine, Chicago, IL Trehan, Sanjay Mittal, Shulian Shang, New York University Medical Center, New York, NY Learning Objective: Describe the short- and mid-term effects of perioperative statin therapy in patients undergoing isolated valvular Learning Objective: Evaluate the outcomes of the RESTOR-MV trial. heart surgery. A146 ABSTRACTS: Valvular Heart Disease JACC March 9, 2010

POSTER CONTRIBUTIONS

1060 MITRAL VALVE RINGS AND THINGS 1061 AORTIC STENOSIS Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Valvular Heart Disease Valvular Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1

1060-375 Mitral Annular Cinching Eliminates Remnant Mitral 1061-381 Veterans Administration Risk Score Accurately Regurgitation after Edge-to-Edge Repair to Correct Predicts Peri-Operative Mortality and Outperforms Posterior Leaflet Prolapse the Euroscore in Aortic Valve Replacement for Aortic Stenosis Muralidhar Padala, Vinod H. Thourani, David H. Adams, Ajit P. Yoganathan, Georgia Institute of Technology, Atlanta, GA Jagroop Basraon, Adheesh Agnihotri, Selcuk Adabag, Marc Pritzker, Elizabeth Ziemba, Rosemary Kelly, Herb Ward, YS Chandrashekhar, Learning Objective: Demonstrate the need for concomitant VA Medical Center, Minneapolis, MN, University of Minnesota, annuloplasty with edge to edge repair Minneapolis, MN 1060-376 The Influence of Annuloplasty Ring Shape on Learning Objective: Understand the relevance of VA Risk Score and Leaflet Curvature in Human Ischemic Mitral EUROSCORE for AVR risk stratification Regurgitation 1061-383 Improvement of Severe Anemia in Patients with mathieu vergnat, Feroze Mahmood, Albert T. Cheung, Kamal Aortic Stenosis Complicated with Gastrointestinal Khabbaz, Stuart J. Weiss, Mickael A. Acker, Robert C. Gorman, Bleeding from Angiodysplasia ( Heyde’s syndrome ) Joseph H. Gorman III, University of Pennsylvania, Philadelphia, PA After Aortic Valve Repair Learning Objective: demonstrates effect of annular shape on human mitral leafet curvature Tomohisa Tada, Toshihiro Tamura, Junichi Tazaki, Toshikazu Jinnai, Neiko Ozasa, Satoshi Shizu, Ko Ono, Hisanori Horiuchi, Takeshi Kimura Kimu, Kyoto University Hospital, Kyoto, Japan 1060-377 Does Mitral Flail in Myxomatous Disease Result of Individual Geometric Predisposition? Learning Objective: describe about acquired von Willebrand syndrome(VWS-2A) caused by aortic stenosis. mathieu vergnat, Xu Chun, Liam P. Ryan, Benjamin M. Jackson, Stuart J. Weiss, Albert T. Cheung, Joseph H. Gorman III, Robert C. Transcatheter Aortic Valve Implantation for Gorman, University of Pennsylvania, Philadelphia, PA 1061-384 Severe Aortic Stenosis - a new paradigm for Learning Objective: describe normal mitral stress pattern multidisciplinary intervention.

Rafal Dworakowski, Philip MacCarthy, Mark Monaghan, Simon 1060-378 Geometric Differences of Mitral Apparatus between Inferior and Anterior Myocardial Infarction with Redwood, Ahmed El-Gamel, Christopher Young, Vinayat Bapat, Jane Hancock, Karen Wilson, Beth Brickham, Kailasam Rajagopal, Emma Significant Ischemic Mitral Regurgitation: Three- Alcock, Olaf Wendler, Martyn R. Thomas, Kings Health Partners, Dimensional Analysis with Multislice Computed London, United Kingdom Tomography Learning Objective: Identify Yoshimori An, Shuichiro Kaji, Kitae Kim, Atsushi Yamamuro, Makoto Kinoshita, Natsuhiko Ehara, Atsushi Kobori, Atsushi Kobori, Takeshi Kitai, Tomoko Tani, Toru Kita, Yutaka Furukawa, Kobe City Medical 1062 CLINICAL PARAMETERS IN DIAGNOSING AND Center General Hospital, Kobe, CA, Japan TREATING VALVULAR DISEASE- THE NEW Learning Objective: understand he precise three-dimensional (3D) FRONTIER geometry of the mitral apparatus in patients with ischemic mitral Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. regurgitation (IMR) accompanied by myocardial infarction Georgia World Congress Center, Hall B5 1060-379 Outcomes of Early Mitral Valve Repair for Severe Presentation Hour: 9:30 a.m. - 10:30 a.m. Degenerative Mitral Regurgitation in Patients CME/CE Hours: 1 with no or Mild Symptoms: Impact of Comorbid Conditions 1062-387 Determinants of Rapid Progression of Aortic Valve Stenosis in Hemodialysis Patients Takeshi Kitai, Tomoko Tani, Shunsuke Funakoshi, Yoshimori An, Kitae Kim, Shuichiro Kaji, Natsuhiko Ehara, Atsushi Yamamuro, Mizuho Hoshina, Hiroshi Wada, Kennichi Sakakura, Nahoko Yukikatsu Okada, Yutaka Furukawa, Kobe City Medical Center Ikeda, Yoshitaka Sugawara, Norifumi Kubo, Junya Ako, Shin-ichi General Hospital, Kobe, FL, Japan Momomura, Cardiovascular Division, Saitama Medical Center, Jichi Medical University, Saitama, Japan Learning Objective: Reconsider optimal timing of mitral valve repair for asymptomatic severe MR with preserved LV function Learning Objective: evaluate determinants of rapid progression of AS in patients on hemodialysis. JACC March 9, 2010 ABSTRACTS: Valvular Heart Disease A147 Valvular Disease Heart

1062-388 Impact of Early Surgery on Long-term Prognosis in 1115-376 Prognostic Significance of Diastolic Dysfunction in Active Left-Sided Infective Endocarditis Unoperated Severe Aortic Stenosis

Shunsuke Funakoshi, Shuichiro Kaji, Noriyuki Kimura, Yoshimori An, Jesse Naghi, Ryan Morrissey, Pavel Goykhman, Asim Rafique, Simon Kite Kim, Takeshi Kitai, Natsuhiko Ehara, Makoto Kinoshita, Atsushi Biner, Robert J. Siegel, Heart Institute, Cedars Sinai Medical Center, Kobori, Atsushi Yamamuro, Tomoko Tani, Michihiro Nasu, Yukikatsu Los Angeles, CA Okada, Yutaka Furukawa, Kobe City Medical Center General Learning Objective: risk stratify patients with severe aortic stenosis Hospital, Kobe, HI, Japan who are not surgical candidates based on echocardiographic Learning Objective: determine whether early valve surgery is diastolic parameter E/E’>15. associated with long-term survival in patients with left-sided infective endocarditis. 1115-377 Edge-to-Edge Tricuspid Valve Repair Is Effective Strategy for the Management of Functional and 1062-389 The Prevalence and Significance of Coronary Organic Tricuspid Regurgitation Disease among High-Risk Patients with Severe Symptomatic Aortic Stenosis Manatomo Toyono, Jose L. Navia, Yoshiki Matsumura, Tetsuhiro Yamano, Takahiro Shiota, Cleveland Clinic, Cleveland, OH, Cedars- Itsik Ben-Dor, Augusto D. Pichard, Lowell F. Satler, Kohei Sinai Medical Center and David Geffen School of Medicine at UCLA, Wakabayashi, Yanlin Li, Asmir I. Syed, Gabriel Maluenda, Manuel Los Angeles, CA A. Gonzalez, Sara D. Collins, Cedric Delhaye, Michael A. Gaglia, Learning Objective: identify the effectiveness of edge-to-edge Rebecca Torguson, Petros Okubagzi, Zhenyi Xue, William O. Suddath, tricuspid valve repair for patients with severe tricuspid regurgitation. Kenneth M. Kent, Joseph Lindsay, Ron Waksman, Washington Hospital Center, Washington DC 1115-379 Procalcitonin is a Marker of Infection After Surgery Learning Objective: To identify the prevalence, and clinical for Valvular Heart Disease in a Predominantly significance of coronary disese and its relation to the severity of the Rheumatic Population calcification or the degree of the stenosis of the aortic valve Antonio C. Bacelar, Flavio Tarasoutchi, Guilherme Spina, Antonio 1062-390 Relationships Between Left Ventricular Mass and A. Lopes, Roney Sampaio, Tarso Accorsi, Ricardo S. Casalino, Aortic Valve Calcification: The Multi-Ethnic Study of Fernando V. Reiche, Max Grinberg, Heart Institute (InCor), University Atherosclerosis of São Paulo Medical Scho, Sao Paulo, Brazil Learning Objective: Demontrate that Procalcitonin is a good marker Sammy Elmariah, Kevin D. O’Brien, Matthew J. Budoff, David A. of infection after surgery for heart valve disease Bluemke, Joseph A. Delaney, Valentin Fuster, Richard A. Kronmal, Jonathan L. Halperin, Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, New York, NY, 1116 PERCUTANEOS AORTIC VALVE THERAPIES IN University of Washington, Seattle, WA 2010 Learning Objective: identify increased left ventricular mass as a risk factor for aortic valve calcification prevalence, severity, and Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. incidence. Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. 1062-391 Preoperative Anemia Increases Mortality and CME/CE Hours: 1 Postoperative Morbidity After Cardiac Surgery Paieon’s C-THV System - A Novel Real-Time Image Antonio Miceli, Paolo M. de Siena, Brenno Fiorani, Francesco 1116-381 Romeo, Gianni D. Angelini, Massimo Caputo, Bristol Heart Institute, Processor to Facilitate Transcatheter Aortic Valve Bristol, United Kingdom Implantation (TAVI). Learning Objective: Demonstrate preoperative anemia is a risk Namal Wijesinghe, Jean-Bernard Masson, Fabian Nietlispach, Edgar factor in cardiac surgery Tay, Ronen Gurvitch, Amir Blumenfeld, Rafi Brada, David A. Wood, John G. Webb, St Paul’s Hospital, Vancouver, BC, Canada, Paieon Medical Ltd, Rosh Haaiyn, Israel 1115 SURGICAL OUTCOMES IN VALVULAR DISEASE Learning Objective: identify new application to facilitate Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. transcatheter aortic valve implantation Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. 1116-382 Transcatheter Valve in Valve Implantation for Failed Bioprosthetic Heart Valves CME/CE Hours: 1 David Alexander Wood, Ronen Gurvitch, Anson Cheung, Jian Ye, 1115-375 Predictors of Outcome in Asymptomatic Patients Jonathon Leipsic, Eric Horlick, Josep Rodés-Cabau, Eric Dumont, with Severe Rheumatic Mitral Regurgitation Mark Osten, Olaf Wender, Jean Bernard Masson, Namal Wijesinghe, Edgar Tay, Fabian Nietlispach, Mark Johnson, Brad Munt, Rob Moss, Duk-Hyun Kang, Dae-Hee Kim, Byung Joo Sun, Jin Oh Na, Jong Christopher R. Thompson, Samuel V. Lichtenstein, John G. Webb, Seon Park, Jong-Min Song, Hyun Song, Joo Hee Zo, Jae-Kwan Song, St. Paul’s Hospital, Vancouver, BC, Canada, University of British Jae-Won Lee, Asan Medical Center, Seoul, South Korea, Catholic Columbia, Vancouver, BC, Canada University Hospital, Seoul, South Korea Learning Objective: Understand that transcatheter valve in valve Learning Objective: demonstrate that the conventional treatment implantation is a reproducible approach for the management of strategy showed satisfactory long-term outcomes in severe, failed bioprosthetic valves regardless of valve position. asymptomatic rheumatic mitral regurgitation. A148 ABSTRACTS: Valvular Heart Disease JACC March 9, 2010

1116-383 Transcatheter Aortic Valve Implantation (TAVI) in 1117-388 Myocardial Fibrosis in Aortic Stenosis: Molecular Bicuspid Aortic Stenosis Mechanisms and an Approach to its Non-Invasive Assesment. Namal Wijesinghe, Fabian Nietlispach, Ronen Gurvitch, Edgar Tay, David A. Wood, Josep Rodés-Cabau, James L. Velianou, Madhu K. Felix M. Valencia-Serrano, Begoña Lopez Salazar, Juan Jose Gomez Natarajan, Jian Ye, Eric Dumont, Anson Cheung, John G. Webb, St Doblas, Javier Diez Martinez, Eduardo de Teresa Galvan, Hospital Valvular Heart Disease Valvular Paul’s Hospital, Vancouver, BC, Canada, Quebec Heart and Lung Universitario Virgen de la Victoria, Malaga, Spain, Centre for Applied Institute, Quebec City, QC, Canada Medical Research, Pamplona, Spain Learning Objective: evaluate the success of transcatheter aortic Learning Objective: Understand the pathophysiological relevance valve implntation for bicuspid aortic stenosis. of myocardial fibrosis in aortic stenosis patients, its molecular mechanisms and an approach to its non invasive assesment. 1116-384 Factors Associated With Cardiac Conduction Disorders and Permanent Pacemaker Implantation 1117-389 Gender Based Differences In Left And Right After Percutaneous Aortic Valve Implantation Ventricular Size And Function In Patients Undergoing Mitral Valve Surgery. Ze Yie Yong, Jan Baan, Jr., Karel T. Koch, José P.S. Henriques, Berto J. Bouma, Marije M. Vis, Riccardo Cocchieri, Jan J. Piek, Bas A.J.M. Karolina M. Zareba, Robert O. Bonow, Asim Ansari, Jyothy de Mol, Academic Medical Center, Amsterdam, The Netherlands Puthumana, Venkatesh Y. Anjan, Brittany R. Lapin, Nausheen Akhter, Patrick M. McCarthy, Vera H. Rigolin, Northwestern University Learning Objective: to be informed about the high incidence of Feinberg School of Medicine, Chicago, IL cardiac conduction disorders after percutaneous aortic valve implantation with the CoreValve device and the factors predicting its Learning Objective: Identify the gender differences in left and right occurrence ventricular volumes and function of patients undergoing mitral valve surgery. 1116-385 Short Term Results of Transcatheter Aortic Valve Implantation: Global and Regional Systolic Left 1117-390 Gender Differences in Operative Rates for Patients and Right Ventricular Function Evaluated by with Severe Aortic Stenosis Echocardiography Extended With Tissue Doppler Maryanne Hartzell, Rajeev Malhotra, Kibar Yared, Malissa J. Wood, Imaging Division of Cardiology, Massachusetts General Hospital, Boston, MA Lena M. Helin, Éva Tamás, Farkas Vánky, Niels Erik Nielsen, Learning Objective: describe the influence of gender on operative Jan Engvall, Eva Nylander, Department of Clinical Physiology, rates for severe aortic stenosis. Department of Medical and Health Sciences University Hospital, Linköping, Sweden, Department of Cardiothoracic Surgery, Heart Thrombocytopenia After Aortic Valve Replacement Centre in Östergötland, University Hospital, Linköping, Sweden 1117-391 With the Freedom Solo Stentless Bioprosthesis: a Learning Objective: evaluate left and right systolic ventricular Propensity-Matched Study function after transcatheter aortic valve implantation by echocardiography and tissue Doppler imaging Dan Rusinaru, Alessandro Piccardo, Benoit Petitprez, Paul Marticho, Ioana Vaida, Christophe Tribouilloy, Thierry Caus, University Hospital Amiens, Amiens, France 1117 NOVEL APPROACHES TO MEASURING Learning Objective: Identify adverse effects associated with OUTCOMES IN VALVULAR DISEASE implantation of stentless bioprostheses Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 1170 BENCH TO BEDSIDE- CELLULAR MECHANISMS Presentation Hour: 3:30 p.m. - 4:30 p.m. OF VALVULAR HEART DISEASE CME/CE Hours: 1 Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. 1117-387 Preoperative Exercise Capacity Best Predicts Georgia World Congress Center, Hall B5 Survival after Surgery for Chronic Nonischemic Presentation Hour: 9:30 a.m. - 10:30 a.m. Mitral Regurgitation CME/CE Hours: 1

Phyllis Supino, Jeffrey S. Borer, Jacek J. Preibisz, Edmund M. Myocardial mRNA Concentrations for Secreted Herrold, Monica M. Diaz, State University of New York (SUNY) 1170-375 Biomarkers in Aortic Regurgitation vs Aortic Downstate Medical Center, Brooklyn, NY Stenosis: Correlations with Plasma Protein Learning Objective: identify the prognostic significance of poor Concentrations and Left Ventricular Dimensions exercise capacity on survival and persistence of symptoms after mitral valve surgery. Daniel Catanzaro, Christopher Stuart, Ji-Sun Hong, Ada Ene, John Carter, Edmund Herrold, Phyllis G. Supino, Jason Lazar, Lou Salciccioli, Wilson Ko, Arash Salemi, Leonard Girardi, Karl H. Krieger, O. Wayne Isom, Jeffrey S. Borer, SUNY Downstate, Brooklyn, NY, Weill Cornell Medical College, New York, NY Learning Objective: understand the basis for the identification of a secreted biomarker that may be relevant to the pathobiology of valvular heart disease JACC March 9, 2010 ABSTRACTS: Valvular Heart Disease A149 Valvular Disease Heart

1170-376 Interaction Between Rosuvastatin And High 1171-383 Prevalence of Silent Cerebral Microembolism after Sensitivity C-reactive Protein On Progression Of Cardiac Catheterization of Patients with High-grade Aortic Stenosis Aortic Stenosis

Kwan-Leung Chan, Andy Ni, James Tam, Randall Sochowski, Jean G. Dieter Ropers, Martin Arnold, Daniel Mundkowski, Josef Ludwig, Dumesnil, John P. Giannoccaro, John Jue, A. Shekhar Pandey, Cam Stephan Achenbach, Werner G. Daniel, Arndt Dörfler, Susanne Joyner, Koon Teo, University of Ottawa Heart Institute, Ottawa, ON, Schulz-Heise, University of Erlangen, Department of Cardiology, Canada Erlangen, Germany Learning Objective: evaluate the effect of rosuvastatin on CRP Learning Objective: to estimate the risk for brain injury of cardiac levels and AS progression. catherization with retrograde passage of the aortic valve in patients with severe aortic valve stenosis 1170-377 The Potential Role of Cholesterol Crystals in the Mechanical Injury of Heart Valves 1171-384 An Analysis of Echocardiographic Variables Associated with Surgical Outcome in Patients with Umesh Tamhane, Ameeth Vedre, Ruiping Huang, Keerthy Narisetty, Severe Aortic Reguritation Due to Behcet Disease Joyce DeJong, George S. Abela, Michigan State University, Lansing, MI Mi-Jeong Kim, Jong-Min Song, Duk-Hyun Kang, Jae-Won Lee, Jae- Learning Objective: Demonstrate the role of cholesterol crystals as Kwan Song, Catholic Univ Incheon St Mary`s Hospital, Incheon, a mechanical cause of valvular injury South Korea, Asan Medical Center, Seoul, South Korea 1170-378 Concurrence Of Neoangiogenesis And Inflammatory Learning Objective: To identify the characteristic morphology in Activation In Leaflets Of Patients With Aortic Valve patients with AR due to Behcet disease Stenosis: An In Vivo Study. 1171-385 Clinical and Echocardiographic Predictors of Long- Maria I. Drakopoulou, Konstantinos Toutouzas, Eleftherios Tsiamis, term Outcome in Asymptomatic Patients with Dimitrios Iliopoulos, Andreas Synetos, Dimitrios Tousoulis, George Significant Aortic Stenosis Agrogiannis, Efstratios Patsouris, Christodoulos Stefanadis, Hippokration Hospital, Athens, Greece, Medical Center, Athens, Duk-Hyun Kang, Jeong-Sook Seo, Byung Joo Sun, Jung Min Ahn, Greece Dae-Hee Kim, Jong-Min Song, Jae-Kwan Song, Hyun Song, Joo Hee Zo, Asan Medical Center, Seoul, South Korea, Boramae Hospital, Learning Objective: Interpret the possible pathophysiologic Seoul, South Korea mechanisms of aortic valve stenosis Learning Objective: identify predictors of outcome in asymptomatic 1170-379 Bisphosphonates Prevent Oxidized Low-Density significant aortic stenosis. Lipoprotein-Induced Expression of Osteogenic Markers in Aortic Valve Myofibroblasts 1172 PROGNOSTIC CLINICAL PARAMETERS IN Sammy Elmariah, Giovanni Cimmino, Valentin Fuster, Juan J. VALVULAR HEART DISEASE Badimon, Zena and Michael A. Wiener Cardiovascular Institute, The Mount Sinai School of Medicine, New York, NY, NY Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Learning Objective: identify bisphosphonates as a potential pharmacologic intervention for aortic stenosis Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1

1171 LONG TERM OUTCOMES IN VALVULAR DISEASE- 1172-387 Preliminary Mechanistic Observations of Decrease NOVEL CLINICAL MARKERS Mitral Regurgitation Severity After Aortic Valve Replacement in Patients with Severe Isolated Aortic Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Stenosis and Functional Mitral Regurgitation Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Visali Kodali, Florentina Petillo, Simcha Pollack, Nathaniel Reichek, CME/CE Hours: 1 Eddy Barasch, St. Francis Hospital/SUNY at Stony Brook, Roslyn, NY Learning Objective: To determine the role of mitral valve geometrical 1171-381 Risk of Silent and Apparent Cerebral Ischemia after changes in the genesis of functional mitral regurgitation in severe Transfemoral Aortic Valve Implantation aortic stenosis.

Philipp Kahlert, Stephan C. Knipp, Marc Schlamann, Matthias The Echocardiographic, Hemodynamic and Left Thielmann, Fadi Al-Rashid, Marcel Weber, Uwe Johansson, Daniel 1172-388 Ventricular Afterload Characteristics of Patients Wendt, Heinz Jakob, Michael Forsting, Stefan Sack, Raimund Erbel, Holger Eggebrecht, West German Heart Center Essen, Department with Severe Isolated Aortic Stenosis, Normal Left of Cardiology, Essen, Germany, West German Heart Center Essen, Ventricular Ejection Fraction and Absence of Left Department of Thoracic and Cardiovascular Surgery, Essen, Ventricular Hypertrophy Germany Visali Kodali, Florentina Petillo, Simcha Pollack, Nathaniel Reichek, Learning Objective: understand that transfemoral aortic valve Eddy Barasch, St. Francis Hospital/SUNY at Stony Brook, Roslyn, NY implantation is associated with a high number of lesions on Learning Objective: To identify by echocardiography the possible cerebral diffusion-weighted magnetic resonance imaging which are mechanisms related to the absence of LVH in severe isolated AS clinically silent. and normal LVEF. A150 ABSTRACTS: Valvular Heart Disease JACC March 9, 2010

1172-389 Relationship between Progression of Aortic 1225-377 Role of Percutaneous Balloon Aortic Valvuloplasty Stenosis and Inflammatory Change in Aortic Valve for Calcific Aortic Stenosis: Updated Technique, in Hemodialysis Patients Indications and Immediate Haemodynamic Results in a Highly Experienced Center Yoshiki Matsumura, Kenichi Sugioka, Takahiko Naruko, Takashi Omura, Tomoyuki Yamakawa, Yoshihiro Ikura, Yasuyuki Kato, Akira Furuta, Karim Bejar, Helene Eltchaninoff, Christophe Tron, Valvular Heart Disease Valvular Toshihiko Shibata, Shigefumi Suehiro, Akira Itoh, Takeshi Hozumi, Brahim Baala, Matthieu Godin, Carlos Sanchez Giron, Bogdan Borz, Minoru Yoshiyama, Makiko Ueda, Department of Internal Medicine Alain Cribier, Hôpital Charles-Nicolle, CHU de Rouen, Rouen, France and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan, Department of Pathology, Osaka City University Learning Objective: evaluate the in-hospital outcome of Balloon Graduate School of Medicine, Osaka, Japan Aortic Valvuloplasty.

Learning Objective: demonstrate that an active inflammatory 1225-378 Percutaneous Pulmonary Valve Replacement: process in the lesion of aortic valve may be one of the mechanisms Autologous Tissue Engineered Valved Stent of rapid progression of AS in hemodialysis patients. Implantation

1172-390 Causes of Death in Asymptomatic Aortic Stenosis in Anja Metzner, Ulrich A. Stock, Gunther Fischer, Wiebke de Buhr, Japan Jessica Boldt, Jochen Cremer, Georg Lutter, Department of Cardiovascular Surgery University Hospital Schleswig-Holstein, Satoko Wada, Takashi Murou, Hiroki Oe, Yoshiki Matsumura, Kenichi Campus Kiel, Kiel, Germany, Department of Thoracic, Cardiac Sugioka, Ryo Ohtsuka, Yasuhiko Takemoto, Takeshi Hozumi, Minoru and Vascular Surgery, University Hospital Tuebingen, Tuebingen, Yoshiyama, Department of Internal Medicine and Cardiology,Osaka Germany City University Medical School, Osaka-shi, Japan Learning Objective: This study demonstrate the combination of Learning Objective: clarify percutaneous valved stent implantation and tissue engineering of autologous heart valves 1172-391 Risk and Outcome of Acute Renal Failure after Transcatheter Aortic Valve Implantation 1225-379 Longitudinal 2D Strain is Superior to EF in Detecting Myocardial Impairment and Postinterventional Philipp Kahlert, Fadi Al-Rashid, Matthias Thielmann, Daniel Wendt, Heinz Jakob, Raimund Erbel, Holger Eggebrecht, West German Improvement in Cardiac Function in Patients with Heart Center Essen, Department of Cardiology, Essen, Germany, Severe Aortic Stenosis Undergoing Transcatheter West German Heart Center Essen, Department of Thoracic and Aortic Valve Implantation Cardiovascular Surgery, Essen, Germany Aleksander Kempny, Gerhard-Paul Diller, Gerrit Kaleschke, Learning Objective: interpret the importance of acute renal failure Gregor Kerckhoff, Stefan Orwat, Monika Anna Stenzel, Julia as an important predictor of patient outcome after TAVI and may Mascherbauer, Holger Reinecke, Helmut Baumgartner, Adult recognize the need for preventive strategies. congenital and valvular heart disease center, University Hospital of Muenster, Muenster, Germany

1225 PERCUTANEOUS VALVE THERAPIES- THE Learning Objective: To understand the role of longitudinal strain in assessing early myocardial damage in patients undergoing CUTTING EDGE transcatheter aortic valve implantation Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 1226 CLINICAL DECISION MAKING IN VALVULAR Presentation Hour: 3:30 p.m. - 4:30 p.m. DISEASE CME/CE Hours: 1 Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. 1225-375 Aortic Regurgitation after Transcatheter Aortic Valve Georgia World Congress Center, Hall B5 Implantation: Insights from Multi-detector Row Presentation Hour: 3:30 p.m. - 4:30 p.m. Computed Tomography CME/CE Hours: 1 Victoria Delgado, CT Arnold Ng, Nico RL van de Veire, Frank van der Kley, Joanne D. Schuijf, Rutger J. van Bommel, Arend de Weger, 1226-381 Pre-Operative Geometry of the Mitral Valve Impacts Giuseppe Tavilla, Miriam Shanks, Louisa M. Antoni, Matteo Bertini, the Outcomes of Mitral Annuloplasty in Ischemic Ernst E. van der Wall, Martin J. Schalij, Jeroen J. Bax, Leiden Mitral Regurgitation University Medical Center, Leiden, The Netherlands Muralidhar Padala, Vinod H. Thourani, David H. Adams, Ajit P. Learning Objective: Demonstrate Yoganathan, Georgia Institute of Technology, Atlanta, GA Learning Objective: Investigate the mechanisms for failure of mitral 1225-376 Percutaneous Paravalvular Leak Closure II - Clinical annuloplasty Data and Short Term Results

Claudia Martinez, Itzhak Kronzon, Vladimir Jelnin, Gila Perk, Howard Cohen, Carlos E. Ruiz, lenox Hill Heart and Vascular Institute, New York, NY, NYU School Of Medicine, New York, NY Learning Objective: evaluate the short term results of percutaneous paravalvular leak repair JACC March 9, 2010 ABSTRACTS: Valvular Heart Disease A151 Valvular Disease Heart

1226-382 Anatomical Classification of Mitral Valve Prolapse 1227-388 Respiratory Variation of Tricuspid Regurgitation: Using Volumetric Analysis of Real-Time Three- Novel Physiologic Insights on the Plasticity of Right- Dimensional Echocardiographic Images Sided Cardiac Cavities.

Sonal Chandra, Ivan S. Salgo, Lissa Sugeng, Wendy Tsang, Lynn Yan Topilsky, Maurice Enriquez-Sarano, Mayo clinic, Rochester, MN Weinert, Victor Mor-Avi, Roberto M. Lang, University of Chicago Learning Objective: Describe respiratory variation of tricuspid Medical Center, Chicago, IL, Philips Healthcare, Andover, MA regurgitation Learning Objective: Classify and distinguish volumetrically the disease process responsible for the prolpase and the cmplexit y of 1227-389 Predictors of Significant Paravalvular Regurgitation MV prolapse specific to each disease process. after Transcatheter Aortic Valve Implantation: Results from the Prospective Multicenter German 1226-383 Prevalence Of Rheumatic Fever/ Rheumatic Heart Aortic Valve Registry Disease In India: Lessons From Active Surveillance And A Passive Registry Mohammad A. Sherif, Mohamed Abdel-Wahab, Volker Geist, Ralph Toelg, Jochen Senges, Steffen Schneider, Gert Richardt, Anil Bharani, M.G.M. Medical College and M.Y. Hospital, Indore, India The German aortic valve registry, Segeberger Kliniken GmbH, Bad Segeberg, Germany Learning Objective: Learn about changing epidemiology and current prevalance and clinical characteristics of RF/RHD in India Learning Objective: identify the predictors of significant AR after PAVR trying to minimize paravalvular AR, and implement the 1226-384 Decision Changes And Its Consequences In Patients appropriate measures with careful screening of patients before With Severe Aortic Stenosis Who Initially Refused intervention Aortic Valve Replacement 1227-390 Long Term Durability Of Edwards Balloon Yoshiki Matsuo, Takashi Kubo, Aiko Shimokado, Kenji Nakamura, Expandable Transcatheter Aortic Valve Implantation Yasushi Okumoto, Hideharu Akagi, Tadao Yamamoto, Takashi Akasaka, Social Insurance Kinan Hospital, Tanabe, Japan, Ronen Gurvitch, Edgar Tay, Anson Cheung, Fabian Nietlispach, Jian Wakayama Medical University, Wakayama, Japan Ye, David A. Wood, Chris Thompson, Namal Wijesinghe, Jonathon Leipsic, Samuel V. Lichtenstein, John G. Webb, St. Paul’s Hospital, Learning Objective: evaluate the prognotic value of therapeutic Vancouver, BC, Canada decisions for patients with sever aortic stenosis Learning Objective: demonstrate long-term durability of 1226-385 Comparison Of The Hemoynamic Performance transcatheter aortic valve replacement And Left Ventricular Remodeling Of Percutaneous Vs Surgical Bioprostheses In Treatment Of Severe 1227-391 Outcomes and Cost of Cardiac Surgery in Aortic Stenosis Octogenarians is Related to Type of Operation: A Multi-Institutional Analysis Cristina Giannini, Marco De Carlo, Fabio Guarracino, Enrica Talini, Maria Grazia Delle Donne, Carmela Nardi, Frank Llojd Dini, Uberto Castigliano M. Bhamidipati, Damien J. LaPar, Edwin Fonner, Jr., John Bortolotti, Gaetano Minzioni, Anna Sonia Petronio, Vitantonio Di A. Kern, Irving L. Kron, Gorav Ailawadi, University of Virginia School Bello, Cardiac Thoracic and Vascular Dept, Pisa, Italy of Medicine, Charlottesville, VA Learning Objective: to demonstrate that the percutaneous Learning Objective: Identify complication risk and related costs to thecnique is better than the surgical approach on the hemodynamic octogenarian patients evaluated for a proposed cardiac operation performance for the treatment of severe aortic stenosis 1278 CELLULAR MECHANISMS IN VALVULAR DISEASE 1227 OUTCOME ANALYSIS IN VALVULAR DISEASE Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 CME/CE Hours: 1 1278-375 Lower Total Arterial Elastance Augments 1227-387 Neurohormonal Prolife And Prognosis In Chronic Regurgitant Volume in Aortic Regurgitation Severe Aortic Regurgitation Of Rheumatic Etiology - Kiyomi Niki, Motoaki Sugawara, Itaru Takamisawa, Hiroyuki A 8 Year Prospective Study Watanabe, Tetsuya Sumiyoshi, Saichi Hosoda, Shuichiro Takanashi, Ricardo S. Casalino, Sr., Guilherme Spina, Antonio C. Bacelar, Roney Tokyo City University, Tokyo, Japan O. Sampaio, Flavio Tarasoutchi, Tarso Accorsi, Max Grinberg, 1Heart Learning Objective: identify the effect of Windkessel function of the Institute (InCor), University of São Paulo Medical School, Sao Paulo, arterial system on aortic regurgitation. Brazil Learning Objective: Identify patients with severe aortic regurgitation at higher risk to become symptomatic A152 ABSTRACTS: Valvular Heart Disease JACC March 9, 2010

1278-376 Anticardiac Antibodies in Acute Rheumatic Fever 1279-382 Plasma Biomarkers of Collagen and Fibronectin and Chronic Rheumatic Heart Disease - Analysis Biosynthesis are Unrelated to Tissue from Indian and Russian Patients Imunohistochemical Protein Quantification or mRNA Determined by Myocardial Biospy Microarray Bernhard Maisch, Daniela Tontsch, Thorsten G. Loof, Gursharan S. in Aortic Valve Disease Chhatwal, Anil Grover, Volker Ruppert, Sabine Pankuweit, Philipps Valvular Heart Disease Valvular University, Department of Cardiology, Marburg, Germany Daniel Catanzaro, Christopher Stuart, Ji-Sun Hong, Ada Ene, John Learning Objective: Identify relevant anticardiac autoreactivity in Carter, Edmund Herrold, Phyllis Supino, Jason Lazar, Lou Salciccioli, rheumatic heart disease Wilson Ko, Arash Salemi, Leonard Girardi, Karl Krieger, O. Wayne Isom, Jeffrey Borer, SUNY Downstate, Brooklyn, NY, Weill Cornell Medical College, New York, NY 1278-377 Elevated Serotonin Levels results in Accelerated Valve Fibrosis in Stretch-Overloaded Aortic Valve Learning Objective: understand the relationship between secreted biomarkers or extracellular matrix protein syntheis and degradation Kartik Balachandran, Adrian Chester, Ajit Yoganathan, Georgia and the myocardial expression of their corresponding genes Institute of Technology, Atlanta, GA Learning Objective: Understand the effects of serotonin and stretch- 1279-383 Cardiopulmonary Responses to Exercise in Patients overload on valve mechanics with Aortic Stenosis: A Descriptive Study of 367 Patients 1278-378 Recombinant Apolipoprotein A-I Milano Decreases Leaflet Inflammation and Calcification in Abhijeet Dhoble, Courtney Hayes, Ray W. Squires, Gerald Gau, Stephen L. Kopecky, Thomas G. Allison, Mayo Clinic, Rochester, MN Experimental Models of Aortic Stenosis Learning Objective: recognize abnormalities in cardiopulmonary Giovanni Cimmino, Walter S. Speidl, Sammy Elmariah, Borja responses to exercise in patients with aortic stenosis Ibanez, Randolph Hutter, Valentin Fuster, Juan Jose Badimon, Atherothrombosis Reserach Unit, Cardiovascular Institute, Mount Tricuspid Regurgitation In Patients With Severe Sinai Hospital, New York, NY 1279-384 Aortic Stenosis: Frequency, Risk Factors and Learning Objective: identify Prognostic Implications In A Cohort of 740 Patients

Padmini Varadarajan, Ramdas G. Pai, Loma Linda University Medical 1278-379 The Association between Arterial Hypertension and Severe Isolated Aortic Stenosis with Preserved Left Center, Loma Linda, CA Ventricular Ejection Fraction; Echocardiographic and Learning Objective: To know the imporatnce of TR in patients with Prognostic Insights severe aortic stenosis

Visali Kodali, Florentina Petillo, Simcha Pollack, Nathaniel Reichek, 1279-385 Early Detection of Improvement of Left Ventricular Eddy Barasch, St. Francis Hospital/SUNY at Stony Brook, Roslyn, NY Function After Undersized Mitral Annuloplasty for Learning Objective: To identify possible mechanisms and the Functional Mitral Regurgitation: Two-Dimensional prognosis of pts with severe AS, normal EF and history of Speckle Tracking Echocardiography hypertension. Yasuhiro Shudo, Satoshi Nakatani, Taichi Sakaguchi, Shigeru Miyagawa, Yasushi Yoshikawa, Takashi Yamauchi, Koji Takeda, 1279 EARLY DETECTION OF VALVULAR DISEASE Shunsuke Saito, Yoshiki Sawa, Osaka University Graduate School of Medicine, Suita, Osaka, Japan Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Learning Objective: Strain in functional MR Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1

1279-381 Measurement Of Cardiac Function Using Pressure- volume Conductance Catheter Technique In A New Rat Model Of Chronic Mitral Regurgitation

Kyong-Hee Kim, Yong-Jin Kim, Hyung-Kwan Kim, Dae-Won Sohn, Byung-Hee Oh, Young-Bae Park, Seoul national university hospital, Seoul, South Korea Learning Objective: We demonstrate a new rat model of mitral regurgitation and evaluate cardiac function using pressure–volume conductance catheter. JACC March 9, 2010 ABSTRACTS: Vascular Disease A153

ORAL CONTRIBUTIONS

915 MODULATORS OF ENDOTHELIAL DYSFUNCTION 921 ANGIOGENESIS: PATHOPHYSIOLOGY -- CLINICAL Monday, March 15, 2010, 4:30 p.m. - 6:00 p.m. Tuesday, March 16, 2010, 10:30 a.m. - 12:00 p.m.

Georgia World Congress Center, Room B403 Georgia World Congress Center, Room B408 Vascular Disease CME/CE Hours: 1.5 CME/CE Hours: 1.5

4:30 Constriction of the Brachial Artery During Brachial 10:30 Angiogenesis and the Progression of Subclinical Artery Reactivity Testing Predicts Major Adverse Atherosclerosis: A 24-Month Follow-Up Study Clinical Outcomes in Women with Suspected Sanghoon Shin, Sang-Hak Lee, Young-Guk Ko, Seok-Min Kang, Myocardial Ischemia: The NHLBI-Sponsored Donghoon Choi, Jong-Won Ha, Namsik Chung, Won-Heum Shim, Women’s Ischemia Syndrome Evaluation (WISE) Seung-Yun Cho, Yangsoo Jang, Yonsei University College of Study Medicine, Seoul, South Korea\ B. Delia Johnson, Steven E. Reis, Sheryl F. Kelsey, Carl J. Pepine, Learning Objective: interpret that the elevation of sFlt-1 is Vera Bittner, William J. Rogers, Eileen Handberg, Wafia Eteiba, potentially related to the progression of atherosclerosis. George Sopko, Barry L. Sharaf, C. Noel Bairey Merz, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA 10:45 The Relationship of Serum Erythropoietin Level with Learning Objective: identify a novel and important non-invasive Coronary Collateral Development tool for estimating risk for major clinical events in women with Asife Sahinarslan, Ridvan Yalcin, Sinan Kocaman, Salih Topal, Ugur suspected myocardial ischemia Ercin, Ali C. Tanalp, Neslihan Bukan, Bulent Boyaci, Atiye Cengel, Gazi University Department of Cardiology, Ankara, Turkey, Ankara, 4:45 Effect of Serum Concentration of Bilirubin in the Turkey Obese Patients: The Action for Coronary Endothelial Function and Inflammatory Stress Learning Objective: Demonstrate the relation between serum erythropoietin level and coronary collateral vessel development Satoshi Yoshino, Shuichi Hamasaki, Sanemasa Ishida, Tetsuro Kataoka, Akiko Yoshikawa, Naoya Oketani, Keishi Saihara, Takuro 11:00 The Relation between Serum Monocyte Takumi, Chuwa Tei, Department of Cardiovascular, Respiratory and Chemoattractant Protein-1 and Coronary Collateral Metabolic Medicine, Kagoshima University, Kagoshima, Japan Development Learning Objective: descrive the effect of serum concentration of Asife Sahinarslan, Sinan Kocaman, Salih Topal, Ugur Ercin, Neslihan bilirubin in the obese patients Bukan, Ridvan Yalcin, Atiye Cengel, Gazi University Department of Cardiology, Ankara, Turkey 5:00 Effects of Smoking and Smoking Cessation on Endothelial Function: One-Year Outcomes from a Learning Objective: These findings demonstrate that higher serum Randomized Clinical Trial MCP-1 level is related with better coronary collateral development.

Linda K. Gossett, Megan E. Piper, Heather M. Johnson, Susan E. 11:15 The Relationship between Plasma Asymmetrical Aeschlimann, Claudia E. Korcarz, Timothy B. Baker, Michael C. Fiore, Dimethylarginine Level and Coronary Collateral James H. Stein, University of Wisconsin School of Medicine and Development Public Health, Madison, WI Asife Sahinarslan, Ridvan Yalcin, Sinan Kocaman, Salih Topal, Ugur Learning Objective: Describe the effects of smoking cessation on Ercin, Neslihan Bukan, Bulent Boyaci, Atiye Cengel, Gazi University endothelial function Department of Cardiology, Ankara, Turkey

5:15 Coronary Microvascular Dysfunction in Primary Learning Objective: These findings demonstrate that asymmetrical Hyperparathyroidism Patients: A Hint for Their dimethylarginine may contribute to the difference in the coronary Increased Cardiovascular Risk collateral development among the patients with similar degree of coronary artery stenosis Elena Osto, Maria R Pellizzo, Francesco Fallo, Anna Maddalozzo, Nadia Sorgato, Roberta Montisci, Sabino Iliceto, Francesco Tona, 11:30 Targeted Delivery of Vascular Endothelial Growth Cardiology,University of Padua, Padua, Italy Factor Favorably Alters Cardiac Remodeling and Learning Objective: identify new determinants of the Function after a Large Myocardial Infarction pathophysiology of coronary microvascular dysfunction in the setting Jenna M. Rosano, Zhanna Ivanov, Robert C. Scott, Bin Wang, of primary hyperparathyroidism Parkson Lee-Gau Chong, Mohammad Kiani, Deborah Crabbe, Temple University, Philadelphia, PA 5:30 Systemic Inflammation and Arterial Endothelial Dysfunction as Possible Mechanisms of Renal Learning Objective: Describe the effects of targeted VEGF therapy Injury in Young Patients with Type 1 Diabetes on left ventricular remodeling and function after a myocardial infarction. Petru Liuba, Peter Holmquist, Pediatric Cardiology, Lund University Hospital, Lund, Sweden Learning Objective: to better understand the mechanisms of diabetes-related vascular complications in young patients with type 1 diabetes A154 ABSTRACTS: Vascular Disease JACC March 9, 2010

925 PULMONARY HYPERTENSION: PREDICTORS OF PROGNOSIS Tuesday, March 16, 2010, 2:00 p.m. - 3:30 p.m. Georgia World Congress Center, Room A408 CME/CE Hours: 1.5

2:00 Prognostic Value of Heart Rate and Systemic Blood Pressure in Pulmonary Arterial Hypertension

Malcolm M. Bersohn, Shelley Shapiro, Michelle P. Turner, Glenna

Vascular Disease Vascular Traiger, Adaani E. Frost, VA Greater Los Angeles Healthcare System, Los Angeles, CA, David Geffen School of Medicine at UCLA, Los Angeles, CA Learning Objective: identify vital sign characteristics that predict a poor outcome in patients with pulmonary arterial hypertension.

2:15 Association of Hyponatremia and Outcomes in Pulmonary Hypertension and Right Ventricular Failure

Asaf Rabinovitz, Ronald Zolty, Montefiore Medical Center, Bronx, NY Learning Objective: appreciate the prognostic significance of hyponatremia in patients with pulmonary hypertension and right ventricular failure

2:30 Clinical and Echocardiographic Predictors of Pulmonary Hypertension in Young Adults: Results from CARDIA

Swathy Kolli, Ren Chen, Maya Guglin, University of South Florida, Tampa, FL Learning Objective: Identify the clinical and echocardiographic predictors of pulmonary hypertension in young adults, from a population based study.

2:45 Pulmonary Artery Stiffness Is Independently Associated with the Degree of Right Ventricular Dysfunction in Pulmonary Hypertension

Gerin Rachel Stevens, Ana Garcia-Alvarez, Sean Pinney, Mario J. Garcia, Valentin Fuster, Javier Sanz, Mount Sinai School of Medicine, New York, NY, Montefiore Medical Center, Bronx, NY Learning Objective: To describe the independent assocations of pulmonary artery stiffness to right ventricular dysfunction in pulmonary hypertension

3:00 Vasodilator Response Predicts Long-Term Survival in Pulmonary Hypertension Regardless of Etiology

Ganesh Devendra, Stephen A. Hart, Shikhar Agarwal, Thomas M. Bashore, Richard A. Krasuski, The Cleveland Clinic, Cleveland, OH, Duke University Medical Center, Durham, NC Learning Objective: Identify the prognostic utility of vasodilator testing in patients with pulmonary hypertension of various etiologies. JACC March 9, 2010 ABSTRACTS: Vascular Disease A155

POSTER CONTRIBUTIONS

1053 PERIPHERAL ARTERIAL/CAROTID DISEASE/ 1053-329 Association between Non-Invasive Arterial Pulse AORTIC DISEASE Volume Recordings and Extent of Coronary Artery Disease

Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Vascular Disease Ashish Parikh, Shailja V. Parikh, Sandeep Das, Tayo Addo, Shoaib Georgia World Congress Center, Hall B5 Saya, Sondra Rolator, Tamra Cooper, Elizabeth Holper, University of Presentation Hour: 9:30 a.m. - 10:30 a.m. Texas - Southwestern, Dallas, TX, University of Missouri - Kansas CME/CE Hours: 1 City School of Medicine, Kansas City, MO Learning Objective: identify whether there is an association between The Effect of Insulin Resistance on the Risk of 1053-324 PVR and CAD Stroke among National Health and Nutrition Examination Survey III Participants Aged 20 Years 1053-330 Predictors Of Subclinical Peri-procedural Blood and Older Loss Associated With Percutaneous Coronary And Jongoh Kim, Bhaskar Purushottam, Aman Amanullah, Albert Einstein Peripheral Intervention. Medical Center, Philadelphia, PA Zehra Jaffery, Arthur G. Grant, Christopher J. White, Ochsner Learning Objective: Recognize increased risk of stroke among those Medical Institution, New Orleans, LA with insulin resistance Learning Objective: Identify predictors of sub-clinical blood loss for coronary and peripheral interventions 1053-325 The Role of Renal Function on the Five-Year Incidence of Cardiovascular Disease in Apparent 1053-331 The 9p21 Genetic Variant Is Additive to Carotid Healthy Individuals; The Attica Study Intima Media Thickness and Plaque in Improving Christina A. Chrysohoou, Christos Pitsavos, Demosthenes B. Coronary Heart Disease Risk Prediction in Panagiotakos, John Skoumas, Yannis Lentzas, Constantina White Participants of the Atherosclerosis Risk in Masoura, Marina Toutouza, Manolis Kambaxis, Lambros Communities (ARIC) Study Papadimitriou, Vasiliki Metaxa, Christodoulos Stefanadis, 1st Cardiology Clinic, Hippokratio, Athens, Greece, Harrokopio Vijay Nambi, Eic Boerwinkle, Kim Lawson, Ariel Brautbar, Lloyd University, Athens, Greece Chambless, Nora Franchescini, Kari North, Salim Virani, Aaron R. Folsom, Christie Ballantyne, Baylor College of Medicine, Houston, TX Learning Objective: Creatinine clearance levels are inversely related with unhealthy lifestyle behaviors and increased inflammatory Learning Objective: understand how to use information about 9p21 markers; while limited creatinine clearance rate increases mutation and carotid initima media thicnkess in coronary heart cardiovascular risk disease risk prediction

1053-327 Chromosome 9p21 Locus Is Associated with 1054 PERIPHERAL ARTERIAL/CAROTID DISEASE/ Vascular Stiffness and CDKN2A Expression in AORTIC DISEASE Human Arteries from Patients Undergoing Coronary Artery Surgery Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Charalambos A. Antoniades, Tim Van-Assche, Colin Cunnington, Dimitris Tousoulis, Cheerag Shirodaria, Christodoulos Stefanadis, Presentation Hour: 9:30 a.m. - 10:30 a.m. Aroon Hingorani, John Deanfield, Keith M. Channon, Stefan CME/CE Hours: 1 Neubauer, Hugh Watkins, Paul Leeson, University of Oxford, Department of Cardiovascular Medicine, Oxford, United Kingdom, 1054-333 The Effect of Gravity on Foot Circulation in Patients University of Athens, Athens, Greece with Critical Limb Ischemia

Learning Objective: Identify the mechanisms by which chromosome Osami Kawarada, Yoshiaki Yokoi, Nobuyuki Morioka, Akihiro 9 locus affects cardiovascular risk Higashimori, Kishiwada Tokushukai Hospital, Kishiwada, Osaka, Japan 1053-328 Monocyte Chemoattractant Protein 1 Predicts First Coronary Events But Not Recurrent Strokes: Results Learning Objective: identiy the effect of gravity on foot circulation from the SPARCL Study 1054-334 Twelve Month Persistence of Poor Response to Peter Ganz, Pierre Amarenco, Larry Goldstein, Henrik Sillesen, Aspirin in Patients with Peripheral Arterial Disease Weihang Bao, Gregory M. Preston, K. Michael Welch, San Francisco Enrolled in the Effect of Lipid Modification on General Hospital, San Francisco, CA Peripheral Arterial Disease after Endovascular Learning Objective: Evaluate the ability of MCP-1 to predict future Intervention Trial (ELIMIT) coronary events and strokes Justin T. Saunders, Vijay Nambi, Salim Virani, Eric Yang, Angela Bergeron, Husam Athamneh, Anirudh Kumar, Joel D. Morrisett, Alan Lumsden, Changyi Chen, Peter Lin, Carlos Bechara, Christie M. Ballantyne, Jing-Fei Dong, Baylor College Of Medicine, Houston, TX Learning Objective: describe the prevalence of clinically poor antiplatelet response to ASA therapy in a group of patients with PAD A156 ABSTRACTS: Vascular Disease JACC March 9, 2010

1054-335 Changes in Thigh Muscle Volume Over a One 1055 PERIPHERAL ARTERIAL/CAROTID DISEASE/ Year Period in Patients With Peripheral Arterial AORTIC DISEASE Disease (PAD): A Magnetic Resonance Imaging (MRI) Analysis from the Effect of Lipid Modification Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. on Peripheral Arterial Disease after Endovascular Georgia World Congress Center, Hall B5 Intervention Trial (ELIMIT) Presentation Hour: 9:30 a.m. - 10:30 a.m. Gerd Brunner, Joel D. Morrisett, Eric Yang, Anirudh Kumar, Salim S. CME/CE Hours: 1 Virani, Panagiotis Kougias, Alan Lumsden, Christie M. Ballantyne, Vijay Nambi, Baylor College of Medicine, Houston, TX 1055-341 Peripheral Arterial Disease Progression in the Bypass Angioplasty Revascularization Investigation Learning Objective: describe the changes in thigh muscle volume 2 Diabetes Trial Vascular Disease Vascular in patients with peripheral arterial disease and the use of MRI in tracking these changes. J. Dawn Abbott, Manuel Lombardero, Jean-Claude Tardif, Ivan Pena- Sing, Luisa Buitron, Prem Singh, Gail Woodhead, Greg Barsness, 1054-336 The Long-term Quality of Life in Patients with Sherry Kelsey, BARI 2D Investigators, Brown University, Providence, Peripheral Arterial Disease After Peripheral Bypass RI, University of Pittsburgh, Pittsburgh, PA Surgery Learning Objective: Describe the annual incidence of a new low Eline S. Van Hattum, Marco J. Tangelder, James A. Lawson, Frans ankle brachial index in medically treated patients with diabetes L. Moll, Ale Algra, University Medical Center Utrecht, Utrecht, The mellitus. Netherlands 1055-342 Increased Angiotensin Converting Enzyme is Learning Objective: describe the health related quality of life about Associated with Increased Inflammation and 10 years after peripheral bypass surgery in patients with peripheral Neovascularization in Peripheral Vascular Disease: arterial disease. Mechanistic Role of Angiotensin II type I Receptor, Interleukin-6, and Tumor Necrosis Factor Alpha in Impairment of Vasomotor Function of Conduit but 1054-337 Diabetic Atherosclerosis not Resistance Arteries after Long-term Femoral Artery Occlusion Purushothaman K-Raman, Prakash Krishnan, Fernando Ruiz, Meerarani Purushothaman, Jose Wiley, Yelena Zubatov, Annapoorna Jin-Shen Li, Lakshmana K. Pendyala, Xinhua Yin, Jianing Yue, Jack P. S. Kini, Samin K. Sharma, John T. Fallon, Valentin Fuster, Pedro R. Chen, Nicolas Chronos, Dongming Hou, Saint Joseph’s Translational Moreno, Mount Sinai Medical Center, New York, NY Research Institute/Saint Joseph’s Hospital of Atlanta, Atlanta, GA Learning Objective: Interpret the role of Angiotensin Converting Learning Objective: evaluate SFA endotehlial function Enzyme-2 in the mediation of inflammation and neovascularization in Peripheral vascular Disease 1054-339 Increasing Carotid Calcifications Are Significantly Associated with Obstructive Carotid Artery Disease 1055-344 Peripheral Arterial Disease Status and John S. Ho, Ben Willis, Dale A. Reinhardt, Mike A. Cornett, Wendy A. Cardiovascular Outcomes in the Bypass Angioplasty Wade, Carolyn Barlow, John J. Cannaday, Cooper Clinic, Dallas, TX, Revascularization Investigation 2 Diabetes Trial The Cooper Institute, Dallas, TX J. Dawn Abbott, Manuel Lombardero, Greg Barsness, Ivan Pena- Learning Objective: Identify the relation between increasing carotid Sing, Luisa Buitron, Prem Singh, Gail Woodhead, Jean-Claude Tardif, artery calcium and obstructive carotid vascular disease. Sherry Kelsey, BARI 2D Investigators, Brown University, Providence, RI, University of Pittsburgh, Pittsburgh, PA 1054-340 Carotid Artery Intima-Media Thickness (CIMT) Learning Objective: Identify that patients with diabetes and an Accretion Rate and Risk of Atherogenesis in a abnormally low or non-compressible ankle brachial index are at an Primary Prevention Population increased risk of mortality. Uchechukwu K.A. Sampson, Fazio Sergio, John W. Patton, Anne- Sophie Sillesen, Amanda K. Wake, Andre L. Churchwell, Alfred 1055-345 Vascular Stiffness as a Predictor of Abnormal S. Callahan, Vanderbilt University Medical Center, Nashville, TN, Myocardial Perfusion in Asymptomatic Patients with Meharry Medical College, Nashville, TN Diabetes Mellitus Learning Objective: The need to incorporate routine CIMT Cornelis J. Roos, Roxana Djaberi, Joanne Schuijf, Eelco J. de determination in risk stratifcation algorithms Koning, Ton J. Rabelink, Jan W. Smit, Alberto M. Pereira, Marcel P. Stokkel, Arthur J. Scholte, Ernst E. van der Wall, J. Wouter Jukema, Jeroen J. Bax, Leiden University Medical Center, Leiden, The Netherlands Learning Objective: identify asymptomatic diabetic patients with an increased risk for coronary artery disease non-invasively, based on arterial stiffnes. JACC March 9, 2010 ABSTRACTS: Vascular Disease A157

1055-346 High Ferritin Levels Confer Lower Cardiovascular 1056-352 Waon Therapy Up-regulates the HSP90 and Leads Risk in Type 2 Diabetes to Angiogenesis Through Akt-eNOS Pathway in a Mouse Model of Hindlimb Ischemia Michel F. Rousseau, Sylvie A. Ahn, Michel P. Hermans, University of Louvain, Brussels, Belgium Takahiro Miyauchi, Masaaki Miyata, Yoshiyuki Ikeda, Yuichi Akasaki,

Narisato Hamada, Takahiro Shirasawa, Hideyuki Eto, Furusho Vascular Disease Learning Objective: To introduce an emerging cardiovascular risk Yuko, Shuichi Hamasaki, Chuwa Tei, Department of Cardiovascular, factor in T2DM Respiratory and Metabolic Medicine, kagoshima, Japan 1055-347 Effect of the Dual Peroxisome Proliferator-Activated Learning Objective: demonstrate that Waon therapy induces Receptor Alpha/Gamma Agonist, Muraglitazar, on angiogenesis Cardiac Structure and Function in Type 2 Diabetic Patients 1056-353 Body Mass Index, Calf Muscle Characteristics and Functional Decline in Peripheral Arterial Disease Vijay U. Rao, Dean Alokozai, Polina Voloshko, Nelson B. Schiller, University of California, San Francisco, San Francisco, CA, Zankhana Raval, Mary M. McDermott, Northwestern University’s Cardiocore, South San Francisco, CA Feinberg School of Medicine, Chicago, IL Learning Objective: describe the effect of the dual peroxisome Learning Objective: describe associations of higher BMI with proliferator-activated receptor agonist, muraglitazar, on cardiac adverse calf muscle characteristics in men and women with lower structure and function in type 2 diabetic patients extremity peripheral arterial disease.

1055-348 Use of Mobile Phone Technology to Improve 1056-354 Favorable Effects of L-arginine on Arterial Function, Outcomes in Patients with Critical Limb Ischemia Inflammatory and Fibrinolytic Process in Smokers and Diabetes Gerasimos Siasos, Dimitris Tousoulis, Charalampos Vlachopoulos, Jenny E. Freeman, Thomas L. Rosser, Matthew Brown, Thomas MJ Elias Gialafos, Evaggelos Oikonomou, Aris Plastiras, Marina Rosser, James F. Toy, IV, JEF Core, Inc., WESTON, MA Zaromitidou, Konstantinos Zisimos, Charalampos Antoniades, Georgia Siasou, Dimitra Papaspiridi, Georgios Marinos, Athanasios Learning Objective: Describe the advantages of cell-phone based G. Papavassiliou, Christodoulos Stefanadis, Hippocration General monitoring of patients with wounds and diabetes and the potential Hospital of Athens, Athens Univercity Medical School, Athens, vallue of applying this technology to the care of patients with critical Greece limb ischemia Learning Objective: evaluate the role of oral l-arginine administration in endothelial function, arterial stiffness, inflammatory and 1056 PERIPHERAL ARTERIAL/CAROTID DISEASE/ fibrinolytic process in healthy smokers AORTIC DISEASE 1056-356 Ethnicity-Specific Associations of Novel Markers of Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. L-arginine Metabolism with the Ankle-Brachial Index Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Faisal F. Syed, Rainer H. Boger, Thomas Mosley Jr, Edzard Schwedhelm, Nicole Lüneburg, Iftikhar J. Kullo, Mayo Clinic, CME/CE Hours: 1 Rochester, MN

1056-350 Comparison Of Various Diagnostic Modalities Learning Objective: Evaluate the associations of markers in the To Evaluate The Efficacy Of Cell-based Vascular L-arginine metabolic pathway with the ankle-brachial index Regeneration Therapy In Patients With Critical Limb Ischemia. 1056-357 Higher Prevalence of Carotid Atherosclerosis in Men with Low HDL-Cholesterol Is Not Related to Makoto Kinoshita, Atsuhiko Kawamoto, Rie Baba, Yutaka Furukawa, Cardiorespiratory Fitness or Inflammation Takayuki Asahara, Institute of Biomedical Research and Innovation, Kobe, Japan, Kobe City Medical Center General Hospital, Kobe, Kevin Heffernan, Richard H. Karas, Jeffrey T. Kuvin, Moon-Kyu Lee, Japan Yoon-Ho Choi, Sae Young Jae, Tufts Medical Center, Boston, MA, Samsung Medical Center, Seoul, South Korea Learning Objective: evaluate the efficacy of vascular regeneration therapy in patients with critical limb ischemia Learning Objective: understand the athero-protective role of HDL-cholesterol as it relates to cardiorespiratory fitness and inflammation. 1056-351 Serum N-terminal pro-B-type Natriuretic Peptide Levels are Associated with Walking Capacity in Patients with Peripheral Arterial Disease

Jin Fan, Hayan Jouni, Kent R. Bailey, Guanghui Liu, Iftikhar J. Kullo, Mayo Clinic, Rochester, MN Learning Objective: Identify a good marker for evaluation dynamic stress in PAD patients. A158 ABSTRACTS: Vascular Disease JACC March 9, 2010

1057 PERIPHERAL ARTERIAL/CAROTID DISEASE/ 1058 ENDOVASCULAR THERAPY AORTIC DISEASE Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 CME/CE Hours: 1 1058-364 Thoracic Endovascular Aortic Repair Versus Medical 1057-358 Clinical Efficacy of Cilostazol after endovascular Treatment For Type B Aortic Dissections. treatment in Patients with Critical Limb Ischemia. A Comparative Retrospective Volumetric Analysis

Vascular Disease Vascular Yoshimitsu Soga, Osamu Iida, Keisuke Hirano, Hiroyoshi Yokoi, MINH HOANG TRAN, Kim-Diep DANG-TRAN, MD, Omar El Aassar, Masaaki Uematsu, Toshiya Muramatsu, Seiki Nagata, Shinsuke Ramiro Moreno, Adil Baali, Benjamin HONTON, Julien Auriol, Nanto, Masakiyo Nobuyoshi, Kokura Memorial Hospital, Kitakyushu, Bertrand Marcheix, Hervé Rousseau, Radiology dep. , CHU-Rangueil, Japan toulouse, France Learning Objective: to evaluate the influence of cilostazol on clinical Learning Objective: understand the rational and superiority of TEVAR outcomes after endovascular treatment in patients with critical limb over medical treatment for aortic dissections type B ischemia 1058-365 Effect Of Renal Impairment In Patients Undergoing 1057-359 Relating Carotid Plaque Volume Reduction Percutaneous Coronary Intervention With Sirolimus- Assessed by 3T MRI with Inflammatory Cytokine eluting Stents Versus Paclitaxel-eluting Stents. Change Following 6 Month Statin Treatment KENNOSUKE YAMASHITA, Masahiko Ochiai, Kazuhiro Ashida, Raymond Q. Migrino, Leanne Harmann, Robert Prost, Mark Bowers, Tadayuki Yakushiji, Myong Hwa Yamamoto, Shigeo Saito, Koichi Medical College of Wisconsin, Milwaukee, WI Hoshimoto, Yuki Mikoshiba, Naoei Isomura, Hiroshi Araki, Chiaki Obara, Showa University Northern Yokohama Hospital, yokohama, Learning Objective: To assess the relationship between plaque Japan component change and cytokines in carotid atherosclerosis. Learning Objective: evaluate the effect of drug-eluting stents for 1057-360 Recombinant Human Interleukin-11 Treatment chronic kidney disease patients Improves Reperfusion And Augments Collateral Vessel Growth In Mouse Model Of Severe Hindlimb 1058-366 Long-term Safety And Efficacy Of A Biodegradable Ischemia Polymer Based Sirolimus Eluting Stents In Treating Diabetic Patients: Subgroup Analysis Of The Create Julius Aitsebaomo, Siddharth Srivastava, Hua Zhang, James E. Study Faber, Cam Patterson, University of North Carolina, Chapel Hill, NC Yaling Han, Quanmin Jing, Yi Li, Gaoliang Yan, Shouli Wang, Yingyan Learning Objective: Identify novel use of recombinant human Ma, Bo Luan, Geng Wang, Shenyang Northern Hospital, Shenyang, interleukin-11 on the treatment of peripheral vascular disease People’s Republic of China

1057-361 Treadmill and Ergometer Exercise Once a Week Learning Objective: evaluate Equally Improve Not only Exercise-tolerance but also Cardio-Renal Function In Peripheral Arterial 1058-367 A Registry of Biodegradable Versus Durable Disease (PAD) Patients with Claudication Polymer Paclitaxel - Eluting Stents.

Masanari Kuwabara, the Department of Genetic Medicine and Peter P. Buszman, Bartlomiej Orlik, Michal Kozlowski, Marek Krol, Regenerative, Tottori University, Tottori, Japan, Hitoshi Anzai, Yutaro Marek Kondys, Janusz Drzewiecki, Michal Tendera, R. Stefan Kiesz, Nishi, Noriaki Hayashida, Ichiro Hisatome, St Luke’s International Pawel E. Buszman, Upper Silesian Heart Center, Katowice, Poland, Hospital, Tokyo, Japan, the Department of Genetic Medicine and Ameican Heart Of Poland, Katowice, Poland Regenerative Therapeutics, Tottori University, Tottori, Japan Learning Objective: Determine whether biodegradable polymer Learning Objective: interpret the importance of exercise coated stents paclitaxel eluting stents are superior to durable rehabilitation in PAD patients with claudication even if the exercise polymer paclitaxel eluting stents is low frequent. 1058-368 Increased Mortality Associated With Impaired 1057-362 Long Term Endothelin Receptor Antagonist Left Ventricular Function Occurs Early After Improves Coronary Endothelial Function in Patients Percutaneous Coronary Intervention with Early Atherosclerosis Ian G. Webb, Kalpa DeSilva, Pierre Sicard, Tim Lockie, Simon Reriani Kaiga Martin, Eugenia Raichlin, Abhiram Prasad, Verghese Redwood, Divaka Perera, St Thomas’ Hospital, King’s Health Mathew, Ryan Lennon, Charanjit Rihal, Lilach Lerman, Amir Lerman, Partners, London, United Kingdom Mayo Clinic, Rochester, MN Learning Objective: To understand the early mortality post PCI in Learning Objective: To demonstrate that endothelin plays a role in patients with impaired LV function inspite of contemporary practice early coronary atherosclerosis JACC March 9, 2010 ABSTRACTS: Vascular Disease A159

1059 ENDOVASCULAR THERAPY 1108 PERIPHERAL ARTERIAL/CAROTID DISEASE/ AORTIC DISEASE Sunday, March 14, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. Georgia World Congress Center, Hall B5 CME/CE Hours: 1 Presentation Hour: 3:30 p.m. - 4:30 p.m. Vascular Disease CME/CE Hours: 1 1059-370 Frequency of Repeat Revascularization after Femoropopliteal Stenting. 1108-324 Assesment Of Elastic Properties Of Aorta To Determine Cardiovascular Risk In Non-obese Atushi Tosaka, Kokura Memorial Hospital, Kitakyushu, Japan Polycystic Ovarian Syndrome Patients Learning Objective: learn Frequency of Repeat Revascularization after Femoropopliteal Stenting. Mehmet Kaya, Ozgur Gunebakmaz, Cemil Zencir, Ayse Yilmazsoy, Mukaddes Karadag, Ramazan Topsakal, Ali Ergin, Fahrettin Kelestemur, Erciyes University, Kayseri, Turkey 1059-371 Six-Month Clinical Outcomes after Below-the-Knee Angioplasty for Critical Limb Ischemia in Patients Learning Objective: Hyperandrogenemia may play a role in the on Hemodialysis prevention of atherosclerosis in non-obese PCOS patients.

Nakano Masatsugu, Toshiya Muramatsu, Reiko Tsukahara, Keisuke Aortic Stiffness in Systemic Lupus Erythematosus Hirano, Yoshiaki Itou, Hiroshi Ishimori, Masahiro Yamawaki, 1108-325 by Transesophageal Echocardiography Motoharu Araki, Yasunari Sakamoto, Shinya Sasaki, Ittuki Komatsu, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan Joseph Joson, Carlos Roldan, Janeen Sharrar, Qualls Clifford, Learning Objective: identify Wilmer Sibbitt, University of New Mexico School of Medicine, Albuquerque, NM 1059-372 A Crossover Balloon Occlusion Technique for Learning Objective: understand the association between systemic Percutaneous Closure After Trans-Femoral Aortic lupus erythematosus and aortic stiffness Valve Implantation 1108-327 Gender Differences in Clinical and Angiographic Philippe Genereux, Mathew Williams, Susheel Kodali, Yanai Ben-Gal, Findings among Korean Patients with Takayasu Craig Smith, Jeffrey W. Moses, Martin B. Leon, Columbia University Arteritis Medical Center, New York, NY Learning Objective: Describe a new, safe and successful adjunctive Ga Yeon Lee, Eunkyung Kim, Mi-rae Lee, Kyoung-Min Byun, Min Ho technique to percutaneous closure device used post transcatheter Kang, Hyejin Han, Seung-Hyuk Choi, Yeon Hyeon Choe, Duk-Kyung aortic valve implantation. Kim, Samsung Medical Center, Seoul, South Korea Learning Objective: identify gender differences in clinical and 1059-373 Feasibility and Durability of Percutaneous Aortic angiographic findings among Korean patients with Takayasu arteritis Valve Replacement: 30-Day and One-Year Outcomes Relationships between Glaucoma, Arterial Stiffness Robert M. Maier, Ronald M. Hoedl, Gergana Stoschitzky, Martin 1108-328 and Inflammatory Process Grabenwoeger, Johann Pollak, Stephan Blazek, Dieter Paetzold, Norbert Watzinger, Burkert M. Pieske, Olev Luha, Medical University Georgia Siasou, Dimitris Tousoulis, Marilita Moschos, Gerasimos Graz, Graz, Austria, Hospital Hietzing, Vienna, Austria Siasos, Elias Gialafos, Evaggelos Oikonomou, Aris Plastiras, Learning Objective: evaluate acute procedural success and mid- Marina Zaromitidou, Konstantinos Zisimos, Aleksios Verveniotis, term outcome of percutaneous aortic valve replacement Charalampos Antoniades, Georgios Marinos, Athanasios G. Papavassiliou, Christodoulos Stefanadis, Hippocration General Comparing the Efficacy and Outcomes of Various Hospital of Athens, Athens Univercity Medical School, Athens, 1059-374 Greece Stents Used in Iliac Artery Revascularization-A Meta-analysis Learning Objective: evaluate the association between arterial stiffness, inflammatory process andsoluble intercellular cells Ankur Sethi, Amol Bahekar, Janos Molnar, Rohit Arora, Rosalind adhesion molecule in primary open-angle glaucoma patients. Franklin University,Chicago Medical School, North Chicago, IL Learning Objective: To interpret difference between various stent 1108-329 Microcirculatory Dysfunction in HIV Infected used in iliac artery revascularization on various end points Patients Ignatios Ikonomidis, John Lekakis, Sotirios Tsiodras, John Palios, Garyfalia Poulakou, Periklis Panagopoulos, Periklis Panagopoulos, Antonios Papadopoulos, Anastasia Antoniadou, Helen Giamarellou, Dimitrios Kremastinos, Attikon University Hospital, Athens, Greece Learning Objective: Identify vascular microcirculation dysfunction in HIV infected patients A160 ABSTRACTS: Vascular Disease JACC March 9, 2010

1108-330 Aortic Elastic Properties Are Altered in Patients 1109-336 Percutaneous Transluminal Angiopmasty and after Kawasaki Disease even without Coronary Stenting of Extracranial Vertebral Artery Stenosis Artery Aneurysm Michel Henry, Isabelle Henry, Antonios Polydorou, Michele Hugel, Dr Jun Oyamada, Manatomo Toyono, Shunsuke Shimada, Mieko Aoki- Henry Michel, Nancy, France Okazaki, Masamichi Tamura, Tsutomu Takahashi, Akita University, Learning Objective: PTA Stenting is the first treatment of the Akita, Japan symptomatic vertebral artery stenosis. The role of DES and embolic Learning Objective: be considered to prevent progression of the protection devices will be discussed. impaired arterial elastic properties with some medical intervention, if necessary. 1109-337 Percutaneous Transluminal Angioplasty of the Subclavian Arteries. Long-Term Follow up

Vascular Disease Vascular 1108-331 Increased NT-pro-BNP Levels in Patients with Peripheral Arterial Disease and “Stiff” Vessels Michel Henry, Isabelle Henry, Antonios Polydorou, Michele Hugel, Dr Henry Michel, Nancy, France Hayan Jouni, Jin Fan, Allison A. Ellington, Kent R. Bailey, Iftikhar Learning Objective: PTA Stenting is the treatment of choice for subclavian J. Kullo, Division of Cardiovascular Diseases, Mayo Clinic, artery lesions with few complications and excellent long-term results. Rochester, MN Learning Objective: Describe the association of NT-pro-BNP levels 1109-339 Factors of Success and Patency after Subintimal with peripheral arterial disease, particularly in the subset with Angioplasty in Patients with TASC C and D Lower “stiff” vessels. Extremity Disease

Weon Kim, Seung-Ju Kim, Won-Yu Kang, Sun-Ho Hwang, Wan Kim, 1109 PERIPHERAL ARTERIAL/CAROTID DISEASE/ Sang-Jin Ha, Kyung Hee University Medical Center, Seoul, South AORTIC DISEASE Korea, Gwangju Veterans Hospital, Gwangju, South Korea Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Learning Objective: demonstrate that lengths of occlusion, distal SFA involving lesion, and post-procedural run-off vessels were strong Georgia World Congress Center, Hall B5 independent predictors for reocclusion in TASC C and D disease Presentation Hour: 3:30 p.m. - 4:30 p.m. that underwent SI-PTA CME/CE Hours: 1 1109-340 Efficacy of Stent-supported Subintimal Angioplasty 1109-333 Renal Angioplasty and Stenting under Protection. in Iliac Artery Occlusive Disease. Limitations. First Human Study with a 3D filter: The Sanghoon Shin, Young-Guk Ko, Jung-Sun Kim, Donghoon Choi, Fibernet TM Myeong-Ki Hong, Yangsoo Jang, Won-Heum Shim, Seung-Yun Cho, Michel Henry, Dr HENRY Michel, NANCY, France Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University, Seoul, South Korea Learning Objective: Current embolic protection devices used in renal angioplasty and stenting have limitations which may be addressed Learning Objective: interpret that stent-supported subintimal by the new Fibernet filter. angioplasty in occlusive iliac lesion is high efficant method.

1109-334 Elevated Intraluminal Velocities After Successful 1110 PERIPHERAL ARTERIAL/CAROTID DISEASE/ Renal Artery Stent Insertion: Is it Time for New Duplex Velocity Criteria Post-stenting? AORTIC DISEASE

Johannes K. Steiner, James T. DeVries, Dartmouth-Hitchcock Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Medical Center, Lebanon, NH Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: interpret increased intraluminal renal artery velocities after stent insertion. CME/CE Hours: 1

A Percutaneous Device for Cerebral Embolic 1109-335 The Utilization of PTFE Covered Stents for the 1110-341 Treatment of Renal Artery In-Stent Restenosis Protection During High Risk Cardiovascular Intervention Nicholas J. Ruggiero, II, Joseph Garasic, Michael R. Jaff, Andrew B. McCann, Thomas J. Kiernan, Brian G. Hynes, Douglas E. Drachman, Jeffrey P. Carpenter, Judith T. Carpenter, Armando Tellez, Juan F. Robert Schainfeld, Kenneth Rosenfield, Gary M. Ansel, Massachusetts Granada, Robert Wood Johnson Medical School, Camden, NJ, Jack General Hospital, Boston, MA, Cardiology Research Foundation, A H. Skirball Center for Cardiovascular Research of the Cardiovascular Division of OhioHealth Research Institute, Columbus, OH Research Foundation, Orangeburg, NY Learning Objective: Evaluate the use of PTFE covered stents for the Learning Objective: describe aortic embolic protection management of renal artery in-stent restenosis JACC March 9, 2010 ABSTRACTS: Vascular Disease A161

1110-342 A Novel Method of Identifying Unstable Plaque by 1110-348 Influence of Participation in Clinical Trials on Simultaneous Carotid Ultrasound and Trans-Cranial Outcomes after Carotid Artery Stenting - Results Doppler from the Carotid Artery Revascularization and Endarterectomy (CARE) Registry George S. Abela, Fadi Shamoun, Muhammad U. Farooq, Kevin

Berger, Dorothy Pathak, Mounzer Kassab, Michigan State University, Robert W. Yeh, Sahil A. Parikh, Kevin F. Kennedy, Rahul Sakhuja, Vascular Disease East Lansing, MI, Sparrow Hospital, Lansing, MI John A. House, Kenneth Rosenfield, Massachusetts General Hospital, Boston, MA, Mid America Heart Institute, Kansas City, MO Learning Objective: To identify plaques at increased risk for stroke Learning Objective: Describe differences in patient characteristics 1110-344 Carotid Revascularization Immediately Prior and outcomes in clinial trial and non-clinical trial patients To Urgent Cardiac Surgery: Clinical Outcomes undergoing carotid artery stenting. Associated With The Choice Of Carotid Artery Stenting (CAS) Or Endarterectomy (CEA) From The 1111 PERIPHERAL ARTERIAL/CAROTID DISEASE/ NCDR-CARE Registry AORTIC DISEASE Creighton W. Don, John House, Kevin Kennedy, Christopher White, Al Woodward, Mary Weideman, Kenneth Rosenfield, University Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. of Washington, Seattle, WA, Massachusetts General Hospital, Georgia World Congress Center, Hall B5 Boston, MA Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: Evaluate the 30 day outcomes of patients CME/CE Hours: 1 undergoing carotid stenting and carotid endarterectomy prior to urgent cardiac surgery 1111-350 The spectrum of Aortic Disease in Loeys-Dietz Syndrome Carotid Angioplasty and Stenting in Octogenarians 1110-345 Chetana Reddy, Angela Sharkey, Alan C. Braverman, Washington Is as Safe as Surgery University School of Medicine, Saint Louis, MO Michel Henry, Isabelle Henry, Antonios Polydorou, Michele Hugel, Dr Learning Objective: Identify the cardiovascular features of Loeys- HENRY Michel, NANCY, France, NANCY, France Dietz syndrome Learning Objective: Carotid angioplasty ans stenting is as safe as surgery in octogenarians and should be the treatment of choice 1111-351 Incidence of Neurologic Deficits in Acute Aortic with experienced operators. Dissection and its Impact on Clinical Outcomes. Insights from the International Registry of Acute 1110-346 Carotid Revascularization Immediately Prior Aortic Dissection (IRAD) to Urgent Cardiac Surgery: Practice Patterns David C. Corteville, Vijay S. Ramanath, Christoph A. Nienaber, Kim Associated with the Choice Of Carotid Artery A. Eagle, James B. Froehlich, Jeanna V. Cooper, Reed E. Pyeritz, Stenting (CAS) Or Endarterectomy (CEA) from The Anna M. Booher, Marek Ehrlich, Truls Myrmel, Patrick O’Gara, Linda NCDR-CARE Registry Pape, Joshua A. Beckman, Santi Trimarchi, Eric M. Isselbacher, Eduardo Bossone, on behalf of the International Registry of Acute Creighton W. Don, John House, Christopher White, Al Woodward, Aortic Dissection (IRAD) investigators, University of Michigan, Ann Kevin Kennedy, Thomas Kiernan, Mary Weideman, Nicholas Arbor, MI Ruggiero, Andrew McCann, Kenneth Rosenfield, University of Washington, Seattle, WA, Massachusetts General Hospital, Learning Objective: To determine the incidence of neurological Boston, MA deficits in type A acute aortic dissection and its impact on clinical outcomes Learning Objective: Identify patient characteristics associated with the use of carotid artery stenting and carotid endarterectomy in patients undergoing urgent cardiac surgery 1111-352 Characteristics Of Aortic Dissection In Patients With Bicuspid Aortic Valve: Insights From the 1110-347 Time Window of Xenon Administration for International Registry of Acute Aortic Dissection Neuroprotective Effects During Transient Middle (IRAD) Cerebral Artery Occlusion Rossella Fattori, Eric M. Isselbacher, Christoph A. Nienaber, James George L. Britton, Jr., Hyunggun Kim, David D. McPherson, Shaoling B. Froehlich, Arturo Evangelista, James L. Januzzi, Craig Strauss, Huang, University of Texas Health Science Center, Houston, TX Guillaume Jondeau, Jeanna V. Cooper, Daniel G. Montgomery, Elise M. Woznicki, Kristian Bartnes, Toru Suzuki, Alan C. Braverman, Kim Learning Objective: At the conlusion of this presentation, attendants A. Eagle, on behalf of the International Registry of Acute Aortic will be able to understand xenon’s role in neuroprotectant following Dissection (IRAD) investigators, University Hospital S. Orsola, an ischemic injury. Bologna, Italy, University of Michigan, Ann Arbor, MI Learning Objective: Describe Characteristics Of Aortic Dissection In Patients With Bicuspid Aortic Valve A162 ABSTRACTS: Vascular Disease JACC March 9, 2010

1111-353 Increased Incidence of Renal Simple Cysts in 1112 ATHEROSCLEROTIC PLAQUE-- Patients with Aortic Dissection and intramural PATHOPHYSIOLOGY—CLINICAL hematoma Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Eunkyung Kim, E Ryoung Choi, Mi-rae Lee, Min Ho Kang, Hyjin Georgia World Congress Center, Hall B5 Han, Ji Hyun Yang, Jeong Rang Park, Bong Gun Song, Yeon Hyun Choe, Young-Soo Do, Wook Sung Kim, Kiick Sung, Pyo-Won Park, Presentation Hour: 3:30 p.m. - 4:30 p.m. Duk-Kyung Kim, Seung-Hyuk Choi, Samsung Medical Center, Seoul, CME/CE Hours: 1 South Korea In Asymptomatic Firefighters the Burden of Learning Objective: demonstrate possible common correlation of 1112-358 renal simple cysts with aortic dissection and intramural hematoma Subclinical Atherosclerosis as Measured by both Coronary Artery Calcification and Carotid Intimal Vascular Disease Vascular Medial Thickening is associated with Metabolic 1111-354 Prevalence and Correlates of Aortic Dilatation in Adolescents and Young Adults: The Strong Heart Abnormalities and but Not with Standard Traditional Study. Serological Risk Factors

Marina De Marco, Mary J. Roman, Giovanni de Simone, Marcello Lakshmana K. Pendyala, Stephen Frohwein, Catherine Skrifvars, Chinali, Lyle G. Best, Elisa T. Lee, Damon Dixon, Barbara V. Howard, Brenda Garrett, Radhika R. Gadesam, Kathryn Momary, H Robert Richard B. Devereux, Federico II University, Napoli, Italy, Cornell Superko, Saint Joseph’s Translational Research Institute, Atlanta, GA Medical College, New York, NY Learning Objective: To identify predictive risk factors fo subclinical Learning Objective: Evaluate prevalence and correlates of aortic atherosclerosis in asymptomatic firefighters dilatation in a population based simple of adolescents and young adults. 1112-359 Factors Influencing The Natural History Of Coronary Atheroma Calcification: Insights From Serial 1111-356 Impact of Imaging Methodology on Measurements Intravascular Ultrasound of Aortic Size in Patients with Thoracic Aortic Andrea Lavoie, Julie Thornton, Kathy Wolski, Kiyoko Uno, Ozgur Aneurysms - Results from the GenTAC Imaging Bayturan, Paul Schoenhagen, Samir Kapadia, E. Murat Tuzcu, Database Steven E. Nissen, Stephen J. Nicholls, The Cleveland Clinic Jonathan W. Weinsaft, Joseph Daoko, Jamie C. Fong, Sonia Sethi, Foundation, Cleveland, OH Dorinna D. Mendoza, Richard B. Devereux, Craig T. Basson, Kathryn Learning Objective: describe the natural progression of coronary Holmes, Poyee P. Tung, Dianna M. Milewicz, Reed Pyeritz, Cheryl calcification and its relationship to atheroma burden Maslen, Barbara Kroner, Donald Brambilla, H. E. Tolunay, Patrice Desvigne-Nickens, Kim Eagle, on behalf of the GenTAC study 1112-360 Aggressive Use of Anti-Atherosclerotic Therapies investigators, Weill Cornell Medical College, New York, NY Slows Progression of Coronary Atheroma in Patients Learning Objective: Evaluate the impact of imaging methodology on with a History of Coronary Revascularization aortic quantification among patients with with genetically triggered aortic aneurysms. Kiyoko Uno, Stephen J. Nicholls, Julie Thornton, Craig Balog, Ozgur Bayturan, Andrea J. Lavoie, Ajai Shreevatsa, Paul Schoenhagen, Samir Kapadia, E. Murat Tuzcu, Steven E. Nissen, Cleveland Clinic, Increased Number of Circulating Endothelial 1111-357 Cleveland, OH Progenitors Cells Are Associated with a Higher Degree of Collateral Circulation in Patients with Learning Objective: evaluate coronary atheroma burden according to CAD with or without prior revascularization

Marcos Ibarra, Victor Ocana, Luis Villela, Erasmo De La Pena- 1112-361 The First in Human Clinical Use of a Combined Near Almaguer, Jesus Siller, Enrique Ponce de Leon, Oscar Fajardo, Infrared Spectroscopy and Intravascular Ultrasound Yolanda Ramos, Jose Borbolla, Guillermo Torre-Amione, Instituto de Catheter to Identify and Characterise Intracoronary Cardiologia y Medicina Vascular Tec de Mty, Monterrey, Mexico, The Plaque (SAVOIR study) Methodist Hospital, Houston, TX Learning Objective: To demonstrate that increased progenitor cells Evelyn Regar, Scot Garg, Martin van der Ent, Carl Schultz, Frits related are related to a higher degree of collateral circulation Mastik, Gijs van Soest, Jolanda J. Wentzel, Patrick W. Serruys, Mark A. Wilder, James E. Muller, Antonius FW van der Steen, Erasmus Medical Center, Rotterdam, The Netherlands Learning Objective: undertsand the potential of invasive imaging for in vivo plaque characterization JACC March 9, 2010 ABSTRACTS: Vascular Disease A163

1112-362 High-density Lipoprotein Cholesterol And C-reactive 1113-368 Relationship of Epicardial Adipose Tissue to Plaque Protein Are Associated with Tissue Composition Vulnerability; the Study Combined Echocardiography of Coronary Atherosclerotic Plaque. - In Vivo and Virtual Histology Intravascular Ultrasound Tissue Characterization by Integrated Backscatter- Jin-Sun Park, So-Yeon Choi, Mingri Zheng, Yun-Suk Park, Eun-Ah Intravascular Ultrasound

Choi, Hyoung-Hwa Han, Hong-Seok Lim, Byoung-Joo Choi, Myeong- Vascular Disease Naoki Nakayama, Kiyoshi Hibi, Masayoshi Kiyokuni, Naohiro Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk, Joon-Han Shin, Ajou Komura, Kazutoshi Minami, Katsutaka Hashiba, Fumiyuki Otsuka, University School of Medicine, Suwon, South Korea Tatsuya Nakachi, Nobuhiko Maejima, Noriaki Iwahashi, Jun Okuda, Learning Objective: To demonstrate the plaque vulnerability and the Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Satoshi unstable clinical presentation of the patients having thick epicardial Umemura, Kazuo Kimura, Yokohama-City University Medical Center, adipose tissue by echocardiography Yokohama, Japan Learning Objective: find the relationship between the tissue components of coronary plaques of culprit lesions and serum 1114 ARTERIAL WALL CHARACTERISTICS -- biomarkers such as high density lipoprotein cholesterol and PATHOPHYSIOLOGY—CLINICAL C-reactive protein. Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 1113 VASCULAR WALL CHARACTERISTICS 2 -- Presentation Hour: 3:30 p.m. - 4:30 p.m. PATHOPHYSIOLOGY—CLINICAL CME/CE Hours: 1 Sunday, March 14, 2010, 1:30 p.m. - 4:30 p.m. 1114-370 Arterial Wall Characteristics Are Associated with Georgia World Congress Center, Hall B5 Incident Cardiovascular Disease: An Analysis from Presentation Hour: 3:30 p.m. - 4:30 p.m. the Atherosclerosis Risk In Communities (ARIC) CME/CE Hours: 1 Study

1113-364 The Different Central Hemodynamics in Patients Eric Y. Yang, Lloyd Chambless, A. Richey Sharrett, Salim S. Virani, with Bicuspid Aortic Valve and its Association with Zhengzheng Teng, Eric Boerwinkle, Christie M. Ballantyne, Vijay Ascending Aorta Dilatation Nambi, Baylor College of Medicine, Houston, TX Learning Objective: Changes in arterial wall stiffness/properties In Jeong Cho, Chi Young Shim, Jeonggeun Moon, Sungha Park, Jong- on carotid ultrasound provide an additional method to evaluate CV Won Ha, Yangsoo Jang, Namsik Chung, Yonsei University College of health of an individual Medicine, Seoul, South Korea Learning Objective: evaluate the risk for subsequent aortic dilation 1114-371 Increased thickness of Aortic and Coronary Wall, in patients with bicuspid aortic valves. and Carotid Intima Media is Associated with Impaired Aortic Distensibility in Subjects without 1113-365 High Pulse Pressure Variation Predicts Mortality Coronary Artery Calcium (from the Multi-Ethnic After Acute Myocardial Infarction Study of Atherosclerosis [MESA])

Petra Barthel, Alexander Müller, Kurt Ulm, Axel Bauer, Marek Malik, Naser Ahmadi, Cuilian Miao, Songshou Mao, Junichiro Takasu, Georg Schmidt, 1. Medizinische Klinik, Klinikum rechts der Isar, Khurram Nasir, W. Craig Johnson, Joseph F. Polak, David Bluemke, Technische Universität München, Munich, Germany Gregory Hundley, Joao A. Lima, Matthew Budoff, Los Angeles Learning Objective: identifiy post-infarction patients at increased Biomedical Research Institute at Harbor UCLA Medical Center, mortality risk by means of a novel hemodynamic parameter Torrance, CA Learning Objective: Increased aortic wall thickness, carotid intima 1113-366 Increased Aortic Augmentation Index in Tako-Tsubo media thickness and coronary wall thickness are association with Cardiomyopathy impaired aortic distensibility across all multi-ethnic groups without coronary calcium Stefan Buchholz, Ravinay Bhindi, Michael R. Ward, Gemma A. Figtree, Royal North Shore Hospital, Sydney, Australia, North Shore Is There A Correlation Between Stiffness Vascular Heart Research Group, Sydney, Australia 1114-372 Parameters And Auto-antibodies Against Nuclear Learning Objective: evaluate the aortic augmentation index Protein Scl-70 In Patients With Systemic Sclerosis?

Concetta Zito, Scipione Carerj, Gianluca Di Bella, Maurizio 1113-367 Asymptomatic Firefighters with Metabolic Syndrome have a High Incidence of both Coronary Cusmà Piccione, Caterina Longordo, Girolamo Gioffrè, Raffaella Iudicello, Maria Rosaria Giuffrè, Roberta Nava, Gianfilippo Bagnato and Carotid Premature Atherosclerosis-associated J, Gianfilippo Bagnato, University of Messina, Department of with Increased Thrombotic and Inflammatory Cardiology, Messina, Italy Markers Learning Objective: Identify early involvement of vascular system in Lakshmana K. Pendyala, CATHERINE SKRIFVARS, BRENDA GARRETT, patients with systemic sclerosis and increased serum levels of Scl- RADHIKA R. GADESAM, KATHRYN MOMARY, H ROBERT SUPERKO, 70 autoantibodies University of Louisville, Louisville, KY Learning Objective: Evaluate the specific risk factors for increased risk for incidence and mortality from CAD in fire fighters A164 ABSTRACTS: Vascular Disease JACC March 9, 2010

1114-373 Effect of Acute Intense Exercise on Arterial Stiffness 1163-327 Significant Differences in Changes of Plaque Composition and Vessel Remodeling between Despina Kardara, Charalambos Vlachopoulos, Aris Anastasakis, Progression and Regression of Coronary Katerina Baou, Ioanna Dima, Dimitrios Terentes-Printzios, Georgios Antoniou, Athanasios Gravos, Grigorios Aggelidis, Christodoulos Atherosclerosis during Statins Therapy: Sub- Stefanadis, 1st Cardiology Department, Athens Medical School, Analysis of TRUTH Study Hippokration Hospital, Athens, Greece Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Shigeo Learning Objective: demonstrate that marathon race results in an Umezawa, Tomoyuki Kunishima, Akira Sato, Shogo Miyake, Youichi acute decrease of wave reflections,indicating reduced afterload and Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, improved left ventricular performance Kiyoshi Hibi, Takashi Sozu, Mitsuyasu Terashima, Ichiro Michishita, Kanagawa PTCA Conference Study Group, Yokohama Sakae Kyosai Increased Pulse Wave Velocity is Associated Hospital, Yokohama, Japan Vascular Disease Vascular 1114-374 with Coronary Artery Calcium in Asymptomatic Learning Objective: learn how coronary artery plaque composition Individuals and vessel remodeling change during progression or regression with statins therapy Souraya Sourayanezhad, Naser Ahmadi, Vahid Nabavi, Braynce L. Oyang, Shahin Moshrefi, Sagar J. Pathak, Hussain sma’eel, Pentraxin 3 Is Involved in Pathogenesis of Unstable Ramin Ebrahimi, Tae Young Choi, Anila Saeed, Matthew Budoff, Los 1163-328 Angeles Biomedical Research Institute at Harbor UCLA Medical Plaque Associated with Intraplaque Hemorrhage Center, Torrance, CA Yunosuke Matsuura, Takuroh Imamura, Kinta Hatakeyama, Yoshisato Learning Objective: Aortic stiffness is associated with the presence Shibata, Tatsuhiko Kodama, Kazuo Kitamura, Yujiro Asada, Miyazaki and severity of coronary artery calcium in asymptomatic individual University, Miyazaki, Japan, Tokyo University, Tokyo, Japan independent of cardiovascular risk factors Learning Objective: To demonstrate what type and characteristic of plaque is associated with PTX3 accumulation in plaque 1163 VASCULAR BIOLOGY/ATHEROSCLEROSIS/ Impact of Lipid-Lowering Therapy on Coronary THROMBOSIS/ENDOTHELIUM 1163-329 Plaque Composition in Patients with Stable Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. and Unstable Angina Evaluated by Intravascular Georgia World Congress Center, Hall B5 Ultrasound with Virtual Histology; Findings from the Presentation Hour: 9:30 a.m. - 10:30 a.m. Subanalyses of the TRUTH Study CME/CE Hours: 1 Hiroyuki Ozaki, Kazuki Fukui, Yasuo Okusu, Tomoyori Nakatogawa, Takeshi Nakagawa, Kiyoshi Hibi, Takashi Sozu, Terashima 1163-324 Interleukin-33 is Expressed in Human Mitsuyasu, Tsuyoshi Nozue, Ichiro Michishita, Kanagawa PTCA Atherosclerotic Tissue and Increases Pro- Conference Study Group, Department of Cardiology, Kanagawa inflammatory Mediators in Human Endothelial Cells Cardiovascular and Respiratory Center, Yokohama, Japan but not in Smooth Muscle and Cardiac Cells. Learning Objective: evaluate the effects of statins on coronary Svitlana Demyanets, Christoph Kaun, Stefan Pfaffenberger, Kathrin plaques in patients with unstable angina Rychli, Igor Huk, Gerald Maurer, Kurt Huber, Johann Wojta, Medical University of Vienna, Vienna, Austria, Wilhelminenhospital, Vienna, 1163-330 Effect of LXR-623, Alone or in Combination with Austria Simvastatin, on Regression and Stabilization of Atherosclerotic Plaques: an MRI Study in a Model of Learning Objective: know that Interleukin-33, a novel member of Advanced Atherosclerosis the IL-1 family of cytokines, induces IL-6, IL-8 and MCP-1 production selectively in human endothelial cells, but not in human cardiac or Chiara Giannarelli, Giovanni Cimmino, Thomas M. Connolly, Borja smooth muscle cell Ibanez, Josè M. Garcia Ruiz, Giora Feuerstein, Matilde Alique, Valentin Fuster, Juan Badimon, AtheroThrombosis Research Lab, 1163-325 Plaque Location in the Left Anterior Descending Cardiovascular Institute, Mount Sinai School of Medicine, New York, Coronary Artery and Tissue Characteristics in NY, Weyth Research, Collegeville, PA Angina Pectoris: An Integrated Backscatter Learning Objective: describe the anti-atherosclerotic effect of Intravascular Ultrasound Study LXR-623, a novel oral LXR agonist, which alone reduces plaque Komura Naohiro, Hibi Kiyoshi, Nakayama Naoki, Kiyokuni progression and combined with statins significantly regress Masayoshi, Minami Kazutoshi, Hashiba Katsutaka, Saka Kenichiro, atherosclerotic lesions. Otsuka Fumiyuki, Nakachi Tatsuya, Maejima Nobuhiko, Iwahashi Noriaki, Okuda Jun, Tsukahara Kenngo, Kosuge Masami, Ebina 1163-331 Wall Shear Stress as a Determinate for Coronary Toshiaki, Umemura Satoshi, Kimura Kazuo, Division of Cardiology, Atherosclerotic Plaque Distribution, Composition Yokohama City University Medical Center, Yokohama, Japan and Remodeling as Assessed by Intravascular Ultrasound and Radiofrequency Tissue Learning Objective: distinguish the tissue characteristics of plaques between proximal and distal left descending coronary artery. Characterization in humans in vivo Holger Hetterich, Ahmad Ibrahim, Moritz Gehring, Tobias Potzger, Thomas Redel, Volker Klauss, Johannes Rieber, University of Munich, Medizinische Poliklinik, Department of Cardiology, Munich, Germany Learning Objective: Understand the correlation of endothelial wall shear stress and coronary atherosclerosis JACC March 9, 2010 ABSTRACTS: Vascular Disease A165

1164 VASCULAR BIOLOGY/ATHEROSCLEROSIS/ 1164-339 The Effect of High Dose Statin Therapy THROMBOSIS/ENDOTHELIUM on Lipoprotein-Associated and Secretory Phospholipase A Mass and Activity and Ischemic 2 Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Events in Patients with Acute Coronary Syndromes Georgia World Congress Center, Hall B5

Sung Kee Ryu, Ziad Mallat, Gregory G. Schwartz, Joelle Benessiano, Vascular Disease Presentation Hour: 9:30 a.m. - 10:30 a.m. Alain Tedgui, Anders G. Olsson, Sotirios Tsimikas, Division Of CME/CE Hours: 1 Cardiovascular Diseases, University Of California San Diego, La Jolla, Ca

RVX-208 Given Orally to Humans Raises Plasma Learning Objective: Demonstrate that high dose atorvastatin 1164-333 therapy reduce Lp-PLA2 and sPLA2 effectively and it is related to ApoA-I and HDL in a Phase 1b/2a Clinical Trial. beneficial clinical outcome Norman C. Wong, Allan Gordon, Jan Johansson, Gregory Wagner, Fabrizio S. Chiacchia, Kevin McLure, Ravi Jahagirdar, Resverlogix 1164-340 The Time to Peak Vasodilatation is Significant Corporation, Calgary, AB, Canada Determinant of Brachial Artery Flow-mediated Learning Objective: A new compound given orally raises apoA-I and Vasodilatation in Hypertension: Analysis Using a HDL. Novel Semi-automatic Vessel Chasing System of UNEXEF18G

1164-334 Simvastatin Improves Endothelium-Dependent Bonpei Takase, Akimi Uehata, Yoshihiro Tanaka, Masayuki Ishihara, Dilation, but Reduces Adiponectin Levels and National Defense Medical College, Tokorozawa, Japan Insulin Sensitivity in Hypercholesterolemic Patients Learning Objective: understand the new parameter and equipment Kwang K. Koh, Michael Quon, Seung H. Han, Kyounghoon Lee, of FMD in Hypertensive patients Gachon University, Incheon, South Korea, NIH, Bethesda, MD

Learning Objective: identify 1165 VASCULAR BIOLOGY/ATHEROSCLEROSIS I

Lipoprotein-Associated Phospholipase A Prediction Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. 1164-335 2 of Coronary Artery Disease Diagnosis Among Georgia World Congress Center, Hall B5 Patients with Differing Numbers of Risk Factors Presentation Hour: 9:30 a.m. - 10:30 a.m. Farangis Lavasani, Heidi T. May, Benjamin D. Horne, Jeffrey CME/CE Hours: 1 L. Anderson, John F. Carlquist, Robert L. Wolfert, Joseph B. Muhlestein, Intermountain Medical Center, Murray, UT 1165-341 Eosinophil Cationic Protein: a new biomarker of Coronary Atherosclerosis. Learning Objective: Evaluate the predictive ability of Lp-PLA2 among those with varying number of risk factors for coronary artery Giampaolo Niccoli, Giuseppe Ferrante, Nicola Cosentino, Micaela disease. Conte, Andrea Silenzi, Flavia Belloni, Marcello Marino, Vito Sabato, Domenico Schiavino, Giampiero Patriarca, Luigi Marzio Biasucci, 1164-336 Extended Release Niacin Improves Lipid Profile but Filippo Crea, Institute of Cardiology, Catholic University of Sacred Not Endothelial Function in Patients with Coronary Heart, Rome, Italy Artery Disease on High Dose Statins Learning Objective: Demonstrates a new marker for coronary atherosclerosis Jaroslav Hubacek, Andrew C. Philpott, Yichun C. Sun, Vincent Lee, Darlene Hilland, Todd J. Anderson, University of Calgary, Calgary, AB, Canada 1165-342 Microalbuminuria in Non-Diabetic Patients with Metabolic Syndrome is a Strong Predictor of Carotid Learning Objective: Evaluate effect of Niacin ER on endothelial Artery Distensibility and Thickness function in CAD patients on optimal statin therapy Pawan K. Hari, Vikas Veeranna, Palaniappan Manickam, Sandeep 1164-337 Resveratrol Counters Atherogenic Effects of Zalawadiya, Simegn Mengistu, Jyotiranjan Pradhan, Sony Jacob, Luis Interferon-gamma on Cholesterol Efflux in THP-1 Afonso, Wayne State University, Detroit, MI Human Monocytes/Macrophages Learning Objective: Identify that microalbuminuria in non-diabetic patients with metabolic syndrome is an incremental predictor of Ofek Y. Hai, Kamran Anwar, Peter A. Wirkowski, Iryna Voloshyna, subclinical atherosclerosis Steven E. Carsons, Allison B. Reiss, Winthrop University Hospital Center, Mineola, NY 1165-344 Circulating Adiponectin as a Predictor of Learning Objective: To demonstrate anti-atherogenic potency of the Vascular Superoxide Generation and Nitric Oxide polyphenol reseveratrol which, through a novel mechanism involving Bioavailability in Human Arteries and Veins enhancement of cholesterol efflux, can counter the atheroma- promoting effect of IFN-g Charalambos A. Antoniades, Cheerag Shirodaria, Paul Leeson, Constantinos Bakogiannis, Michael Dimosthenous, Alexis S. Antonopoulos, Dimitris Tousoulis, Nikolaos Sfyras, Christodoulos Stefanadis, Keith M. Channon, University of Oxford, Department of Cardiovascular Medicine, Oxford, United Kingdom, University of Athens, 1st Department of Cardiology, Athens, Greece Learning Objective: Interpret the role of adiponectin in the regulation of vascular function A166 ABSTRACTS: Vascular Disease JACC March 9, 2010

1165-345 Plasma Osteopontin Levels Were More Elevated 1166-351 Subendothelial Matrix Composition Influences IFN- In Coronary Artery Than In Systemic Circulation In Gamma induced MHCII-Expression by Endothelial Patients With Acute Coronary Syndrome Cells

Yoshinori Yasuoka, Motohiro Kosugi, Ryo Araki, Takahiro Imanaka, Heiko Methe, Jong-Oh Kim, Department of Cardiology, University Ryo Matsutera, Susumu Hattori, Yoshiki Noda, Hidenori Adachi, Hospital Grosshadern, Munich, Germany Hiroaki Irino, Tatsuya Sasaki, Osaka Minami Medical Center, Osaka, Learning Objective: appreciate that contact of endothelial cells with Japan their underlying basement membrane influences endothelial cell Learning Objective: interpret OPN in coronary artery as direct behavior in health and disease. inflammatory biomarker in ACS 1166-352 The Therapeutic Angiogenesis and Systemic

Vascular Disease Vascular 1165-346 The Association of Cox-2 Inhibitors and Non- Endothelial Tone selective Nonsteroidal Antiinflammatory Medications with D-dimer in the Multi-Ethnic Study Gen Takagi, Masaaki Miyamoto, Ikuyo Takagi, Shuhei Tara, Yasuhiko Tabata, Kyoichi Mizuno, Nippon Medical School, Tokyo, Japan of Atherosclerosis (MESA) Learning Objective: Identify the relation between endothelial Stewart G. Allen, Mary Cushman, David Sane, Craig Johnson, David function and therapeutic angiogenesis Herrington, Wake Forest University School of Medicine, Winston- Salem, NC 1166-353 Torcetrapib Induces Endothelial Dysfunction in Learning Objective: Describe the association between the use of Spontaneously Hypertensive Rats COX-2 inhibitors and Non-selective Nonsteroidal Antiinlfammatory Medications and D-dimer levels. Branko Simic, Matthias Hermann, Sidney Shaw, Thomas F. Luescher, Frank Ruschitzka, Cardiovascular Research, Department for Effect Of Bariatric Surgery On Flow Mediated Physiology, University of Zurich-Irchel, Zurich, Switzerland, University 1165-347 Hospital Zurich, Division of Cardiology, Zurich, Switzerland Dilation And Coronary Microvascular Function Learning Objective: understand potential mechanisms about Gaetano A. Lanza, Pierpaolo Tarzia, Roberto Nerla, Antonio Di cardiovascular risk observed for torceptrapib. Monaco, Daniele Matera, Francesco Greco, Roberto M. Tacchino, Alfonso Sestito, Filippo Crea, Università Cattolica del Sacro Cuore, mir-155 and mir-221/222 Attenuate Angiotension Rome, Italy 1166-354 II Induced Endothelial Inflammation by Targeting Learning Objective: To evaluate the effect of bariatric surgery on ETS-1 peripheral and coronary endothelial function Ni Zhu, Yongwen Qin, Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of 1165-348 Plasma Heme oxygenase-1 Level Is Associated with the Presence of Coronary Artery Disease and China Unstable Clinical Presentation Learning Objective: demosnstrate endothelial highly expressed miRNA may regulate endothelial inflammatory response William Chan, Swati Mukherjee, Bronwyn A. Kingwell, Anthony J. White, James A. Shaw, Alaina Natoli, Beth Johnson, Anthony S. Simvastatin and Aspirin Decrease Angiogenesis by Walton, Anthony M. Dart, Stephen J. Duffy, The Alfred Hospital, 1166-356 Enhancing VE-cadherin Expression Melbourne, Australia Learning Objective: appreciate that plasma heme oxygenase-1 level Magomed Khaidakov, Jacob Szwedo, Sona Mitra, Jawahar L. Mehta, is associated with the presence of coronary artery disease and UAMS, Little Rock, AR unstable clinical presentation Learning Objective: To identify mechanisms responsible for angiostatic effects of statins and aspirin 1166 VASCULAR BIOLOGY/ATHEROSCLEROSIS/BASIC 1166-357 Upregulation of Ca 1.2 Expression in Atherosclerosis SCIENCE V Wenze Wang, Sung W. Rhee, Chien Chen, Philip Palade, Jawahar L. Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. Mehta, University of Arkansas for Medical Sciences, Little Rock, AR Georgia World Congress Center, Hall B5 Learning Objective: Evaluate involvement of CaV1.2 channels in Presentation Hour: 9:30 a.m. - 10:30 a.m. atherosclerosis CME/CE Hours: 1

1166-350 Effect of Ramiprilat-Coated Stent in a Porcine Coronary Restenosis Model

Young Joon Hong, Myung Ho Jeong, Jung Ha Kim, Kyung Seob Lim, Jum Suk Ko, Min Goo Lee, Doo Sun Sim, Keun Ho Park, Nam Sik Yoon, Hyun Ju Youn, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang, Heart Center of Chonnam National University Hospital, Gwangju, South Korea Learning Objective: to examine the anti-proliferative and anti- inflammatory effects and arterial healing of ramiprilat-coated stent in a porcine coronary overstretch restenosis model. JACC March 9, 2010 ABSTRACTS: Vascular Disease A167

1167 VASCULAR PHYSIOLOGY-- PATHOPHYSIOLOGY— 1167-362 Arterial Wall Remodeling in Association with CLINICAL Abdominal Obesity, Adipocytokines and Progression of Coronary Atherosclerosis: Insights from The Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. STRADIVARIUS Study Georgia World Congress Center, Hall B5

Kiyoko Uno, Stephen J. Nicholls, Jean-Pierre Després, Mingyuan Vascular Disease Presentation Hour: 9:30 a.m. - 10:30 a.m. Shao, Tingfei Hu, Paul Schoenhagen, Ozgur Bayturan, Andrea J. CME/CE Hours: 1 Lavoie, Ajai Shreevatsa, Samir Kapadia, Venu Menon, Christophe Gaudin, Bernard Job, E. Murat Tuzcu, Steven E. Nissen, Laval Hospital 1167-358 Heart Vessel Coupling in Subject with Risk Factors: Research Center, Sanofi-Aventis, Cleveland Clinic, Cleveland, OH A Longitudinal Left Ventricular Function and Arterial Learning Objective: characterize arterial wall remodeling associated Stiffness Study with weight loss and atherosclerosis Concetta Zito, Maurizio Cusmà Piccione, Gianluca Di Bella, Raffaella Iudicello, Caterina Longordo, Carmelo Nipote, Maria Rosaria Giuffrè, 1168 ATHEROSCLEROTIC RISK FACTORS 2 -- Roberta Nava, Girolamo Gioffrè, Scipione Carerj, University of Messina, Department of Cardiology, Messina, Italy PATHOPHYSIOLOGY—CLINICAL Learning Objective: Evaluate the relationship between LV Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. longitudinal systolic function and arterial stiffness parameters in Georgia World Congress Center, Hall B5 subjects with traditional risk factors Presentation Hour: 9:30 a.m. - 10:30 a.m. CME/CE Hours: 1 1167-359 Association of N-Terminal-Pro-B-type Natriuretic Peptide and Acetylcholine-induced Coronary Artery 1168-364 Drivers of Progression of Coronary Atherosclerosis Spasm and 12 Month Clinical Outcome in Patients with Chronic Kidney Disease

Ji Young Park, Seung Woon Rha, Kanhaiya L. Poddar, Sureshkumar Amar Krishnaswamy, Amy Hsu, Samir R. Kapadia, Paul Ramasamy, Lin Wang, Byoung Geol Choi, Ji Bak Kim, Seung Yong Schoenhagen, E. Murat Tuzcu, Steven E. Nissen, Stephen J. Shin, Un Jung Choi, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Nicholls, Cleveland Clinic, Cleveland, OH Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Korea University Guro Hospital, Seoul, South Korea Learning Objective: evaluate the impact of traditional risk factors for CAD in patients with CKD Learning Objective: we evaluated the impact of NT-pro BNP on the acterylcholin induced coronary artery spasm and 12 month clinical Hypertension in Offspring of Pregnancies outcome 1168-365 Complicated by Pre-eclampsia: Underlying Vascular Mechanisms? 1167-360 Psoriasis Early Impairs Coronary Flow Reserve: new Insights Into Inflammation and Coronary MERZAKA LAZDAM, Alex Pitcher, Arancha de la Horra, Ilias Microvascular Dysfunction Kylintireas, Zola Mannie, Jonathan Diesch, Corinne Trevitt, Atul Singhal, Alan Lucas, Stefan Neubauer, Nicholas Alp, Brenda Kelly, Elena Osto, Stefano Piaserico, Anna Maddalozzo, Giulia Forchetti, Paul Leeson, University of Oxford, Oxford, United Kingdom Roberta Montisci, Andrea Peserico, Sabino Iliceto, Francesco Tona, Cardiology,University of Padua, Padua, Italy Learning Objective: Demonstrate that the pathology underlying the development of hypertension differs between premature offspring Learning Objective: consider new determinants of the born following preeclampsia or normotensive pregnancy pathophysiology of coronary microvascular dysfunction in the setting of psoriasis 1168-366 Vascular Superoxide As A Signaling Molecule Triggering Adiponectin Biosynthesis In Perivascular Brachial-Ankle Pulse Wave Velocity Correlated 1167-361 Adipose Tissue, In Human Atherosclerosis with an Endothelium-Independent Vasodilation in Conduit Coronary Artery Constantinos Bakogiannis, Charalambos A. Antoniades, Alexis S. Antonopoulos, Dimitris Tousoulis, Antigoni Miliou, Costas Takuro Kubozono, Masaaki Miyata, Sanemasa Ishida, Tetsuro Triantafyllou, Nikolaos Sfyras, Costas Psarros, Keith M. Channon, Kataoka, Akiko Yoshikawa, Naoya Oketani, Hideki Okui, Takuro Christodoulos Stefanadis, 1st Cardiology Department Hippokration Shinsato, So Kuwahata, Hitoshi Ichiki, Shoji Fujita, Satoshi Yoshino, Hospital, Athens, Greece, University of Oxford, Oxford, Greece Daisuke Kanda, Osamu Fukumoto, Shuichi Hamasaki, Chuwa Tei, Department of Cardiovascular, Respiratory and Metabolic Medicine, Learning Objective: Identify the mechanisms regulating adiponectin Kagoshima University, Kagoshima, Japan synthesis in perivascular adipose tissue in human atherosclerosis Learning Objective: We elucidated the association between baPWV Vitamin D Levels Do Not Predict Cardiovascular and coronary artery function. 1168-367 Events in Statin-Treated Patients with Stable Coronary Disease

Vera Bittner, Nanette K. Wenger, David D. Waters, David A. DeMicco, Michael Messig, John C. LaRosa, University of Alabama at Birmingham, Birmingham, AL, Emory University, Atlanta, GA Learning Objective: Determine the effect of serum vitamin D levels on CV morbidity and death in a population of statin-treated patients with stable CHD A168 ABSTRACTS: Vascular Disease JACC March 9, 2010

1168-368 Young Patients Infected with Human 1169-374 Enhanced External Counterpulsation Immunodeficiency Virus Have Elevated Reduces Vascular Inflammation Promoted by Concentrations of Asymmetric Dimethylarginine Hypercholesterolemia and Coronary Artery Calcification William E. Lawson, Yan Zhang, Xiaohong He, Donghong Liu, Guifu James J. Jang, Ashok Krishnaswami, Sarah Berkheimer, Kaiser Wu, Yan Zhang, Xiaolin Chen, Hong Ma, Zhimin Du, Yugang Dong, Permanente, San Jose Medical Center, San Jose, CA Yafei Jin, Wen He, Kuijian Wang, John CK Hui, Zhensheng Zheng, The Key Laboratory on Assisted Circulation, Guangzhou, People’s Learning Objective: Identify that young HIV-infected patients have an Republic of China, First Affiliated Hospital, Sun Yat-Sen University, increased risk for cardiovascular disease. Guangzhou, People’s Republic of China Learning Objective: Evaluate potential role of increased shear 1169 VASCULAR THERAPY-- PATHOPHYSIOLOGY— Vascular Disease Vascular stress in attenuating vascular inflammation and injury CLINICAL Monday, March 15, 2010, 9:30 a.m. - 12:30 p.m. 1218 INFLAMMATION AND ENDOTHELIAL FUNCTION Georgia World Congress Center, Hall B5 Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. Georgia World Congress Center, Hall B5 CME/CE Hours: 1 Presentation Hour: 3:30 p.m. - 4:30 p.m. CME/CE Hours: 1 1169-370 Atorvastatin Worsens Glucose Metabolism and Insulin Sensitivity in Patients with Metabolic Inflammation is Associated with Endothelial Syndrome/type 2 Diabetes 1218-324 Dysfunction Among Individuals with Treated and Kwang K. Koh, Michael Quon, Seung H. Han, Kyounghoon Lee, Suppressed HIV Infection Gachon University, Incheon, South Korea, NIH, Bethesda, MD Priscilla Y. Hsue, Peter W. Hunt, Amanda Schnell, Jennifer Ho, Yuaner Wu, Rebecca Hoh, Jeffrey N. Martin, Steven G. Deeks, Peter 1169-371 Use of Non-Steroidal Anti-Inflammatory Drugs and Ganz, University of California, San Francisco, San Francisco, CA Type-Specific Risk of Acute Coronary Syndrome Learning Objective: understand the mechanism underlying accelerated atherosclerosis in HIV infected individuals Hector Bueno, Alfredo Bardají, Paola Patrignani, Elisa Martín-Merino, A. García-Rodríguez, on behalf of the Spanish Case-Control Study to assess NSAID-associated ACS risk, Hospital General Universitario 1218-325 CD28 null T Lymphocytes are expanded in Young Gregorio Maranon, Madrid, Spain, CEIFE, Madrid, Spain Women with Polycystic Ovary Syndrome Learning Objective: know what kind of coronary risk is associated Giampaolo Niccoli, Rosanna Apa, Giovanna Liuzzo, Cristina Spaziani, with the use of NSAIDs Francesca Sagnella, Andrea Silenzi, Rocco A. Montone, Giuseppe Ferrante, Antonio Lanzone, Filippo Crea, Institute of Cardiology, 1169-372 Brief Low-workload Myocardial Ischemia Induces Catholic University of Sacred Heart, Rome, Italy Protection Against Increased Exercise-related Learning Objective: demonstrates the presence of an abnormal Platelet Reactivity In Patients With Coronary Artery expansion of CD4+CD28null T lymphocytes in young women with Disease polycystic ovary syndrome, providing a potential mechanism of increased cardiovascular risk. Gaetano A. Lanza, Giancarla Scalone, Ilaria Coviello, Gaetano Pinnacchio, Lucy Barone, Chiara Pisanello, Roberto Mollo, Priscilla First Demonstration by Immuno-Electron Lamendola, Fabio Infusino, Filippo Crea, Università Cattolica del 1218-327 Microscopy that Both Hepatic and Intestinal Sacro Cuore, Rome, Italy Lipoproteins Contribute to Human Atherosclerosis Learning Objective: To describe the effect of a preconditioning-like model of ischaemia on platelet function Jesus Gustavo Vazquez Figueroa, Sarah Rinehart, Laura Murrieta, Patrick Battey, Tamio Teramoto, Teruhiko Matsushima, Zhen Qian, Idean B Marvasty, Szilard Voros, Piedmont Heart Institute, Atlanta, GA 1169-373 The Effects of Pioglitazone in Reducing Atherosclerosis Progression and Neointima in Learning Objective: Demonstrate by Immunohistochemistry Dabetic Patients: Prospective Randomized Study and Immunofluorescence the presence of ApoB48 in human with IVUS volumetry atherosclerotic plaques.

Jae Hyoung Choi, Sung Hye You, Bum-Suk Kim, Soon Jun Hong, 1218-328 Oxidative Stress In Response To High Glucose Levels Chul-Min Ahn, Je Sang Kim, Jae Hyoung Park, Do-Sun Lim, Korea In Endothelial Cells And In Endothelial Progenitor University Anam Hospital, Seoul, South Korea Cells. Evidence For Differential Responses Learning Objective: learn about PPAR agent on coronary atherosclerosis and neointimal hyperplasia Alberto Balbarini, Francesca Felice, Maria Chiara Barsotti, Laura Pucci, Daniela Lucchesi, Giuseppe Penno, Stefano Del Prato, Rossella Di Stefano, Cardiac, Vascular and Thoracic Department , University of Pisa, Pisa, Italy, Department of Endocrinology and Metabolism, Section of Metabolic Diseases and Diabetes, University o, Pisa, Italy Learning Objective: identify the differential responses of the endothelial progenitor cells to oxidative stress JACC March 9, 2010 ABSTRACTS: Vascular Disease A169

1218-329 Nebivolol Stimulates Endothelial Nitric Oxide 1219-334 Arterial Stiffness is Associated With Left Ventricular Release in White and Black Americans Through Systolic and Diastolic Function in Never-treated an ATP Autocrine Pathway and Beta3-Receptor Hypertensives Activation Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Athanasios

Richard Preston Mason, Ruslan Kubant, Adam M. Jacoby, Robert Bratsas, Konstantinos Aznaouridis, Nikolaos Alexopoulos, Katerina Vascular Disease F. Jacob, Yoshiko Mizuno, Tadeusz Malinski, Brigham and Women’s Baou, Nikolaos Ioakeimidis, Aikaterini Siama, Panagiota Pietri, Hospital, Harvard Medical School, Boston, MA Christodoulos Stefanadis, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece Learning Objective: understand the pharmacologic basis for endothelial-dependent nitric oxide release with nebivolol Learning Objective: Identify the connection between arterial stiffness and left ventricular function. 1218-330 Establishing the Links Between the Soluble Receptor for Advanced Glycation End Products, 1219-335 Prenatal Stress Alters Atherosclerotic Lesion Asymmetric Dimethylarginine and Low-Grade Vulnerability in Adult Offspring Inflammation in Essential Hypertension Nima Aghili, Amir Najafi, XinZhi Peng, Ken Abe, Zofia Zukowska, Konstantinos P. Tsioufis, Kyriakos Dimitriadis, Costas Thomopoulos, Stephen E. Epstein, Mary Susan Burnett, Medstar Research Dimitris Syrseloudis, Antigoni Miliou, Kostas Toutouzas, Elli Institute, Washington, DC, Georgetown University, Washington, DC Stefanadi, Dimitris Tousoulis, Christodoulos Stefanadis, First Learning Objective: To demonstrate the effect of prenatal stress on Cardiology Clinic, University of Athens, Hippokration Hospital, atherosclerotic lesion vulnerability Athens, Greece Learning Objective: describe the relationships of the soluble 1219-336 Is there a gender disparity in risk Association of receptor for advanced glycation end products with C-reactive protein Inflammatory Biomarkers with New Onset Diabetes and asymmetric dimethylarginine in hypertension in Healthy Adult Population?

Genetic Polymorphism on Adiponectin Gene Sandip K. Zalawadiya, Ashutosh Niraj, Vikas Veerana, Jyotiranjan 1218-331 Pradahan, Sidakpal Panaich, Jacob Sony, Luis Afonso, Wayne State Regulates Arterial Superoxide Generation, by University/Detroit Medical Center, Detroit, MI Affecting Adiponectin Biosynthesis in Adipose Tissue from Patients with Atherosclerosis Learning Objective: hypothesize possible pathophysiological mechanisms behind gender differences in NOD risk prediction for Alexis S. Antonopoulos, Charalambos Antoniades, Dimitris these bimarkers and thereby, possibly insulin resistance and related Tousoulis, Constantinos Bakogiannis, Antigoni Miliou, Nikolaos cardiovascular outcomes. Sfyras, Michael Dimosthenous, Costas Psarros, Kyriakoula Marinou, George Ekonomopoulos, Christodoulos Stefanadis, Hippokration 1219-337 Preventive Effect Of Exenatide To Endothelial Hospital, Athens, Greece Dysfunction Induced By Ischemia-reperfusion Injury Learning Objective: Evaluate the effects of adiponectin gene Via Adp K Channels variability on adiponectin synthesis in human adipose tissue and vascular redox state Sang Jin Ha, Weon Kim, Jong Shin Woo, Tae-kyung Yu, Soo Joong Kim, Woo-Shik Kim, Myeong Kon Kim, Kwon Sam Kim, Kyunghee University Medical Center, Seoul, South Korea 1219 VASCULAR FUNCTION AND Learning Objective: demonstrate that subcutaneous exenatide PROATHEROSCLEROTIC FACTORS induces potent protection against IR-induced endothelial dysfunction through of KATP channel. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 1219-339 Association of Plasma Matrix Metalloproteinase-9 Presentation Hour: Levels with Subclinical Atherosclerosis and Vascular CME/CE Hours: 1 Stiffness in Healthy Subjects

Jonathan R. Murrow, Ibhar Al Mheid, Nino Kavtaradze, Sarfraz 1219-333 Clustering of Metabolic Syndrome Components Attenuates Coronary Plaque Regression with Ali, Konstantinos Aznaouridis, Muhiddin Ozkor, Jesse Jorgensen, Saurabh Dhawan, Hamid Syed, Riyaz Patel, W. Craig Hooper, Intensive Statin Therapy in Acute Coronary Christine DeStareck, R. Wayne Alexander, Arshed Quyyumi, Emory Syndrome: Serial Intravascular Ultrasound Analysis University, Atlanta, GA, Centers for Disease Control, Atlanta, GA from the JAPAN-ACS Study Learning Objective: To describe the relationship between MMP-9 Hiroaki Takashima, Yukio Ozaki, Kenji Asai, Yoshinori Wakita, and vascular health. Yasuo Kuroda, Takashi Kousaka, Yasushi Kuhara, Tomofumi Mizuno, Akiyoshi Kurita, Kazuyuki Maeda, Yasushi Wakida, Takayuki Ito, Takeshi Kimura, Takeshi Morimoto, Takafumi Hiro, Katsumi Miyauchi, Yoshihisa Nakagawa, Masakazu Yamagishi, Kazuo Kimura, Satoshi Saito, Tetsu Yamaguchi, Hiroyuki Daida, Masunori Matsuzaki, Department of Cardiology, Aichi Medical University, Nagakute, Japan A170 ABSTRACTS: Vascular Disease JACC March 9, 2010

1219-340 Effects of an Intensive Glycemic Control with Insulin 1220-346 Flow Mediated Dilation Causes A Transient on Platelet Aggregation Profile in Patients with Impairment Of Endothelial Function Which Is Acute Coronary Syndrome: the CHIPS (Control de Abolished By L-arginine la Hiperglucemia y Función Plaquetaria en los Gaetano A. Lanza, Roberto Nerla, Antonio Di Monaco, Pierpaolo Síndromes Coronarios Agudos) Study Tarzia, Giulia Careri, Alfonso Sestito, Filippo Crea, Università David Vivas, Esther Bernardo, Juan Carlos Garcia-Rubira, Dominick Cattolica del Sacro Cuore, Rome, Italy J. Angiolillo, Patricia Martin Rojas-Marco, Alfonso Calle, Carlos Learning Objective: To describe the reduction of NO bioavailability Macaya, Antonio Fernandez-Ortiz, Cardiovascular Institute, San observed early after FMD assessment Carlos University Hospital, Madrid, Spain, University of Florida College of Medicine-Jacksonville, Jacksonville, FL 1220-347 The Contribution of Nitric Oxide and Endothelium-

Vascular Disease Vascular Learning Objective: Evaluate how an intensive glycemic control Derived Hyperpolarizing Factor to Resting and results in a reduction of platelet aggregation profile Stimulated Vasodilator Tone in African American and Whites

1220 VASCULAR BIOLOGY/ATHEROSCLEROSIS/ Muhiddin A. Ozkor, Jonathan R. Murrow, Ayaz Rahman, Nino THROMBOSIS/ENDOTHELIUM Kavtaradze, Shawn Arshad, Hamid Syed, Ji Lin, Amita Manatunga, Arshed A. Quyyumi, Emory University, Atlanta, GA Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Learning Objective: Demonstrate the differential contribution of Georgia World Congress Center, Hall B5 endothelial-derived vasodilators in the healthy vasculature of Presentation Hour: 3:30 p.m. - 4:30 p.m. different races. CME/CE Hours: 1 1220-348 Association between Advanced Endothelial 1220-341 Usefulness of an Abnormal Aortic/penile Index to Dysfunction and Vulnerable Coronary Plaques in Predict the Presence of Coronary Artery Disease in High Risk Patients with Suspected Coronary Artery Erectile Dysfunction Patients Disease

Nikolaos Ioakeimidis, Charalambos Vlachopoulos, Athanasios Yasushi Matsuzawa, Seigo Sugiyama, Kazuo Kimura, Hisao Ogawa, Aggelis, Nikolaos Alexopoulos, Dimitrios Terentes-Printzios, Department of Cardiovascular Medicine, Graduate School of Athanasios Bratsas, Panagiotis Xaplanteris, Katerina Baou, Medical Sciences, Kumamoto University, Kumamoto, Japan, Division Konstantinos Rokkas, Christodoulos Stefanadis, Cardiovascular of Cardiology, Yokohama City University Medical Center, Yokohama, Diseases and Sexual Health Unit, 1st Department of Cardiology, Japan Athens Medical School, Athens, Greece Learning Objective: This study demonstrates the utility of endothelial dysfunction assessed by RH-PAT to identify vulnerable 1220-342 Gap Junction Modulation Prevents Endothelial patients with vulnerable plaques requiring aggressive and intensive Dysfunction Induced by Ischemia-Reperfusion Injury treatment. in Man

Christian M. Pedersen, Ninian Lang, Gareth D. Barnes, Michael R. 1221 VASCULAR BIOLOGY/ATHEROSCLEROSIS/ Schmidt, Hans Erik Botker, Rajesh K. Kharbanda, Nick L. Cruden, THROMBOSIS/ENDOTHELIUM David E. Newby, University of Edinburgh, Centre for Cardiovascular Science, Edinburgh, United Kingdom, Aarhus University Hospital Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Skejby, Aarhus, Denmark Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: demonstrate that enhanced gap junction communication afford protection against ischemia- reperfusion CME/CE Hours: 1 injury induced endothelial dysfunction. 1221-350 Local Intracoronary Rosiglitazone Treatment 1220-344 Progression Of Atherosclerosis In An Asymptomatic Induces a Vasoprotective Gene Expression Profile Population - Effect Of Lipid Subclass and Complete Reendothelialization in A Porcine In Stent-restenosis Model Ankit D. Rathod, Apurva Badheka, Palaniappan Manickam, Vikas Veeranna, Rajeev Sudhakar, Tamam Mohamad, Sony Jacob, Luis Stefanie I. Utchil, Chantip Dang-Heine, Jens Klinowski, Diana Bösel, Afonso, Wayne State Univeristy, Detroit, MI Carolin Deiner, Heinz-Peter Schultheiss, Klaus Pels, Department of Cardiology and Pneumology, Charité – Campus Benjamin Franklin, Learning Objective: Identify Lipid subclasses associated with Berlin, Germany progression of atherosclerosis in asymptomatic patients. Learning Objective: evaluate the effects of local rosiglitazone 1220-345 Glitazones and the Endothelium (GATE) Study: treatment on different gene expression Effect of Rosiglitazone on Endothelial Function in Type 2 Diabetes Mellitus

Jaroslav Hubacek, Subodh Verma, S. J. Ross, A. Edwards, Lana Shewchuk, Todd J. Anderson, University of Calgary, Calgary, AB, Canada Learning Objective: describe the effect of rosiglitazone on endothelial function in DM2 patients with sub-optimal glycemic control JACC March 9, 2010 ABSTRACTS: Vascular Disease A171

1221-351 Platelet Reactivity after Thienopyridine Treatment: 1222 ACUTE AND CHRONIC PULMONARY EMBOLISM Assessment with Screen Filtration Pressure Method and Drug-Eluting Stent Thrombosis Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Georgia World Congress Center, Hall B5 Shuichi Oshima, Katuso Noda, Hironobu Fukushima, Shinichi Presentation Hour: 3:30 p.m. - 4:30 p.m.

Nakamura, Izumi Taniguchi, Fumihito Kugimiya, Kenichiro Higa, Vascular Disease Tsunenori Nishijima, Shinsuke Hanatani, Division of Cardiorogy, CME/CE Hours: 1 Kumamoto Central Hospital, Kumamoto City, Japan 1222-358 Heightened Platelet Reactivity defines Chronic Learning Objective: evaluate whether thienopyridine low Thromboembolic Pulmonary Hypertension from responsiveness can predict adverse clinical events after drug- other Subtypes of Pulmonary Hypertension eluting stent implantation. Ronan J. Margey, Sean Gaine, Aaron Peace, Tony Tedesco, Dermot 1221-352 The Effect of St. John’s Wort on the Kenny, Mater Misericordiae University Hospital, Dublin, Ireland, Pharmacodynamic Efficacy of Clopidogrel in University College Dublin, Dublin, Ireland Hyporesponsive Volunteers and Patients Learning Objective: Identify a new potential explanation for disease Wei C. Lau, Terrence D. Welch, Theresa A. Shields, Melvyn progression in patients with thromboembolic related pulmonary Rubenfire, Paul A. Gurbel, University of Michigan, Ann Arbor, MI hypertension Learning Objective: understand the pharmacodynamic mechanism 1222-359 Association of Alleles From Inflammatory, Vaso- of how St. John’s wort enhances clopidogrel in clopidogrel architecture, and Coagulation Pathways With hyporesponsive volunteers and patients. Clinical Characteristics of a Deep Vein Thrombosis 1221-353 Assessment of Dual Antiplatelet Responsiveness Deanna S. Cross, Mark Craven, Steven Yale, Marshfield Clinic with the Point-Of-Care Device VerifyNow after Research Foundation, Marshfield, WI, University of Wisconsin- Percutaneous Coronary Intervention in Elderly Madison School of Medicine and Public Health, Madison, WI Patients (≥75 years) Learning Objective: Evaluate the utility of utilizing multiple A M Tidjane, R. Ghenim, V. Bongard, N. Boudou, N. Dumonteil, N. alleles from a number of pathways for determining the clinical Hammami, A. Ziani, J. Roncalli, Th Lhermusier, P. Sié, D. Carrié, characteristics of DVT. Cardiovascular and Metabolic Pole, Toulouse, France, Hematology Laboratory, Toulouse, France 1222-360 Regional Right Ventricular Strain Pattern in Patients with Pulmonary Embolism

In-stent Restenosis is Associated With Neointimal Elke Platz, Amira Hassanein, Samuel Z. Goldhaber, Frank Rybicki, 1221-354 Scott D. Solomon, Brigham and Women’s Hospital, Boston, MA Angiogenesis and Macrophage Infiltrates Learning Objective: Understand the role of strain imaging in Nathaniel B. Cresswell, Wei-Sing Chu, Erik Mont, Allen Burke, Armed pulmonary embolism Forces Institute of Pathology, Washington, DC, Nova Scotia Medical Examiners Office, Halifax, NS, Canada 1222-361 Preoperative Partitioning Of Pulmonary Vascular Learning Objective: To identify the role of angiogenesis in in-stent Impedance: A Novel Hemodynamic Index For restenosis Operable And Inoperable Chronic Thromboembolic Pulmonary Hypertension 1221-356 Clinical and Genetic Determinants of Clopidogrel Non-responsiveness in Koreans Maria J. Ruiz-Cano, Juan C. Grignola, Pilar Escribano, José Cortina, Teresa Velázquez, Miguel A. Gómez Sánchez, Juan F. Delgado, Jin Joo Park, Kyung-Woo Park, Ki-Hyun Joen, Si-Hyuck Kang, Hae- Carlos Sáenz de la Calzada, Unidad de HTPulmonar y Tx Cardíaco, Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Byung-Hee Oh, Young- Servicio de Cardiología, Hospital Universitario “12 de Octubre”, Bae Park, Hyo-Soo Kim, Department of Internal Medicine and Madrid, Spain, Depto Fisiopatología, Hospital de Clínicas, Facultad Cardiovascular Center, Seoul National University Hospital, Seoul, de Medicina, Universidad de la República, Montevideo, Uruguay South Korea Learning Objective: consider a novel hemodynamic index to evaluate Learning Objective: The participants wll learn that clopidogrel non- proximal vs distal disease in chronic thromboembolic pulmonary responsiveness is a multifactorial phenomenon contributed by hypertension. genetic and and clinical factors. 1222-362 The Efficacy and Therapeutic Role of Balloon 1221-357 Downstream Coronary Effects of Drug Eluting Pulmonary Angioplasty in Patients with Chronic Stents: Unintended Therapeutic Target? Thromboembolic Pulmonary Hypertension

George Cater, Ganesh P. Devendra, Mehdi Shishehbor, Steven E. Hiroki Mizoguchi, Hiromi Matsubara, Mitsuru Munemasa, National Nissen, Stephen G. Ellis, Richard A. Krasuski, The Cleveland Clinic, Hospital Organization, Okayama Medical center, Okayama, Japan Cleveland, OH Learning Objective: Interpret the downstream effects of drug-eluting stents on de-novo atheroma development. A172 ABSTRACTS: Vascular Disease JACC March 9, 2010

1223 VENOUS THROMBOSIS/PULMONARY 1223-368 How Treatment Changes Sleep Apnea Syndrome In EMBOLISM/PULMONARY HYPERTENSION Patients With Pulmonary Arterial Hypertension Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Seiichi Taniai, Toru Satoh, Masaharu Kataoka, Takashi Kawakami, Yuichi Tamura, Takanori Ikeda, Konomi Sakata, Hideaki Yoshino, Georgia World Congress Center, Hall B5 Kyorin University School of Medicine, Mitaka, Japan, Keio University Presentation Hour: 3:30 p.m. - 4:30 p.m. School of Medicine, Tokyo, Japan CME/CE Hours: 1 Learning Objective: identify a change of sleep apnea after drug treatment of pulmonary arterial hypertensionof 1223-364 Long Term Effect Of Bosentan Therapy On Cardiac Function And Symptomatic Benefits In Patients With Eisenmenger Syndrome 1224 VENOUS THROMBOSIS-PROPHYLAXIS Vascular Disease Vascular Mehmet Kaya, Yat Yin Lam, Betul Erer, Selim Ayhan, Mehmet A. Monday, March 15, 2010, 1:30 p.m. - 4:30 p.m. Vatankulu, Zekeriya Nurkalem, Mehmet Eren, Namik K. Eryol, Georgia World Congress Center, Hall B5 ERCIYES UNIVERSITY, KAYSERI, Turkey Presentation Hour: 3:30 p.m. - 4:30 p.m. Learning Objective: Bosentan therapy results in long term CME/CE Hours: 1 improvement of pulmonary hypertension and RV function in ES patients. These hemodynamic improvements should provide 1224-370 Three-Month Cumulative Incidence of insights on the symptomatic benefits gained in Thromboembolism and Bleeding After Periprocedural Anticoagulation Management of 1223-365 Oxidative Stress And Its Relation With Peripheral Patients with Venous Thromboembolism Endothelial Function And Pulmonary Vascular Response To Vasodilators In Pulmonary Artery Robert D. McBane, II, Waldemar E. Wysokinski, Paul R. Daniels, Hypertension Scott Litin, Joshua Slusser, David Hodge, John A. Heit, Mayo Clinic, Rochester, MN Luigi Gabrielli, Pablo F. Castro, Douglas Greig, Ivan Godoy, Hugo Learning Objective: Define the incidence of thromboembolism (TE) Verdejo, Mario Chiong, Pablo Sepulveda, Lorena Garcia, Sergio and bleeding related to peri-procedural anticoagulation management Lavandero, Robert C. Bourge, Pontificia Universidad Catolica, in patients with venous thromboembolism. Santiago, Chile, Universidad de Chile, Chile

Learning Objective: To evaluate the role of oxidative stress and its 1224-371 Does Rivaroxaban Provide a Clinically Relevant relation with peripheral endothelial function and pulmonary vascular Favorable Benefit-Risk Profile Compared with response to vasodilators. Enoxaparin After Hip or Knee Arthroplasty?

1223-366 Echocardiographic Predictors of Declining Exercise Sanjay Kaul, George A. Diamond, Cedars-Sinai Medical Center, Los Performance in Children with Sickle Cell Disease Angeles, CA

Niti Dham, Gregory Ensing, Mehdi Nouraie, Lori Luchtman-Jones, Learning Objective: Critically evaluate the benefit-risk assessment Andrew D. Campbell, Manuel Arteta, Sohail R. Rana, Caterina of Rivaroxaban compared to enoxaparin in preventing venous Minniti, Gregory J. Kato, Mark Gladwin, Oswaldo L. Castro, Victor thromboembolism after hip or knee arthroplasty R. Gordeuk, Craig A. Sable, Children’s National Medical Center, Washington, DC, Howard University, Washington, DC 1224-372 Pharmacologic Prophylaxis for Venous Thromboembolism: The Most Frequent Reason for Learning Objective: Identify the association of tricuspid regurgitation Omitting Ordered Doses Is Patient Refusal and left ventricular size with a 6-minute walk test in children with sickle cell disease John Fanikos, Leslie-Ann Stevens, Gregory Piazza, Mathew Labreche, Elaine Catapane, Lena Novack, Samuel Z. Goldhaber, Brigham and 1223-367 Local Pulmonary Artery Stiffness Indexes Are Women’s Hospital, Boston, MA Correlated With Steady And Pulsatile Components Learning Objective: Identify barriers to VTE prophylaxis. Of Right Ventricular Afterload In Pulmonary Arterial Hypertension 1224-373 Subcutaneous FIXa Inhibitor Provides Prolonged Juan C. Grignola, Enric Domingo, Carlos Bravo, Rio Aguilar, Manuel Anticoagulation: The First Successful Subcutaneous Lopez-Messeguer, Manuel Vazquez, Antonio Roman, Area del Cor Application of an Aptamer and Servei de Pneumologia i CIBERES, Hospital Universitari Vall Christopher P. Rusconi, Doug Kornbrust, Steven L. Zelenkofske, Hebron, Barcelona, Spain, Dept Physiology, Universitat Autonoma Regado Biosciences, Inc, Durham, NC Barcelona, Barcelona, Spain Learning Objective: Describe the PK/PD properties of anticoagulant Learning Objective: understand the importance of local pulmonary aptamers following subcutaneous administration and the ability artery stiffness indexes in pulmonary arterial hypertension and its to control their anticoagulant effects using IV administered active relationship with steady and pulsatile afterload control agents. JACC March 9, 2010 ABSTRACTS: Vascular Disease A173

1224-374 A Novel Three-Screen Computer Alert to Increase 1271-330 Does Longterm Endurance Running Enhance the Rate of Venous Thromboembolism Prophylaxis or Inhibit Coronary Artery Plaque Formation? A Prospective Multidetector CTA Study of Men Karen Fiumara, Chiara Piovella, Shelley Hurwitz, Gregory Piazza, Completing Marathons for least 25 Consecutive Clyde Niles, John Fanikos, Marilyn Paterno, Matthew Labreche, Leslie-Ann Stevens, Steven Baroletti, Samuel Z. Goldhaber, Brigham Years Vascular Disease and Women’s Hospital, Boston, MA, Boston, MA Jonathan G. Schwartz, Stacia Merkel-Kraus, Sue Duval, Kevin Learning Objective: Identify barriers to VTE prophylaxis Harris, Gretchen Peichel, John R. Lesser, Thomas Knickelbine, Bjorn Flygenring, Terry R. Longe, Catherine Pastorius, William R. Roberts, Stephen C. Oesterle, Robert S. Schwartz, University of Colorado, 1271 EXERCISE AND VASCULAR MODULATION Denver, CO, Minneapolis Heart Institute Foundation, Minneapolis, MN Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Learning Objective: Understand the role of chronic exercise on Georgia World Congress Center, Hall B5 coronary artery plaque formation Presentation Hour: 9:30 a.m. - 10:30 a.m. 1271-331 Galectin-2 Expression Is Dependent on the CME/CE Hours: 1 3279C>T Polymorphism and Is Associated with Arteriogenesis in Patients with Coronary Artery Atrial Fibrillation Is Not Associated With Increased 1271-324 Disease Progression of Coronary Atherosclerosis: Insights From Intravascular Ultrasound Atherosclerosis Trials Anja M. Van Der Laan, Stephan Schirmer, Oscar Volger, Margreet de Vries, Jasper de Koning, Joost Fledderus, Josefien Baggen, Reina Ozgur Bayturan, E Murat Tuzcu, Mingyuan Shao, Andrea J. Lavoei, Mebius, Tineke van der Pouw-Kraan, Paul Quax, Jan Piek, Anton Kiyoko Uno, Kathy Wolski, Paul Schoenhagen, Samir R. Kapadia, Horrevoets, Niels van Royen, Academic Medical Center, University Steven E. Nissen, Stephen J. Nicholls, Cleveland Clinic, Cleveland, of Amsterdam, Amsterdam, The Netherlands, VU University Medical OH Center, Amsterdam, The Netherlands Learning Objective: To describe the relationship of atrial fibrillation Learning Objective: identify the relation between Galectin-2 and atheroma burden in coronary artery patients expression in monocytes and the arteriogenic response in patients with coronary artery disease. 1271-325 Aerobic Fitness Strongly Associated With Thrombotic Risk Markers Than Fatness In Firefighters 1272 BIOMARKERS AND VASCULAR DISEASE 3

RADHIKA R. GADESAM, Catherine Skrifvars, Brenda Garrett, Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Lakshmana Pendyala, Andrew Huang, Kathryn Momary, Stephen Georgia World Congress Center, Hall B5 C. Frohwein, Melissa Clay, David Dusik, Bill Myers, Steve Rolader, Presentation Hour: 9:30 a.m. - 10:30 a.m. Robert H. Superko, Saint Joseph Hospital, Atlanta, GA, Gwinnett CME/CE Hours: 1 County Fire and Emergency Services, Lawrenceville, GA Learning Objective: Improving aerobic fitness in firefighters may be 1272-333 Microparticles Shedding after Percutaneous more effective in decreasing thrombotic risk than weight loss Coronary Intervention in Unstable Angina Is modulated by Myocardial Necrosis and Systemic 1271-328 The Impact of Early Compared to Late Morning Inflammation Hours on Brachial Endothelial Function and Long- Term Cardiovascular Events in Healthy Subjects Luigi M. Biasucci, Luca Di Vito, Italo Porto, Giovanni L. De Maria, With no Apparent Coronary Heart Disease Giuliana Di Rocco, Alessandra Tritarelli, Alessandra Paglia, Margherita Marcantoni, Maurizio C. Capogrossi, Filippo Crea, Michael Shechter, Liran Hirsh, Nira Koren-Morag, Micha S. Feinberg, Catholic University, rome, Italy, IDI, Rome Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Israel, Learning Objective: descibe mechnism of endothelial damage Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Learning Objective: To find out the impact of early morning hours 1272-334 Relationship Between Coronary Artery Plaque on brachial flow-mediated dilation and long-term cardiovascular Composition And Brachial-ankle Pulse Wave outcome. Velocity In Patients With Coronary Artery Disease: A Virtual Histology Intravascular Ultrasound Analysis 1271-329 Effect of Candesartan with Pioglitazone on Coronary Endothelial Function and Vascular Inflammation in Sang-Wook Kim, Jee-Eun Kwon, Gary S. Mintz, Min-Suk Oh, Wang- Porcine Coronary Arteries Implanted with Sirolimus- Soo Lee, Kwang-Je Lee, Tae-Ho Kim, Chee-Jeong Kim, Neil J. eluting Stents Weissman, Wang-Seong Ryu, Chung-Ang University Hospital, Seoul, South Korea, Cardiovascular Research Foundation, New York, NY Tomotaka Dohi, Katsumi Miyauchi, Ryo Tsuruta, Naozumi Kubota, Learning Objective: interpretate that high baPWV indicates more Takatoshi Kasai, Takhumi Iesaki, Hiroyuki Daida, Juntendo severe CAD (smaller MLA) and greater atherosclerosis disease University, Department of Cardiology, Tokyo, Japan complexity (more calcified coronary plaque). Learning Objective: demonstrate that candesartan and pioglitazone protected against endothelial dysfunction and vascular inflammation following sirolimus-eluting stent implantation. A174 ABSTRACTS: Vascular Disease JACC March 9, 2010

1272-335 Prediction of Cardiovascular Events in Statin- 1273 BIOMARKERS AND VASCULAR DISEASE Treated Stable Coronary Patients by C-Reactive Protein Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Georgia World Congress Center, Hall B5 John Kastelein, on behalf of the TNT Steering Committee, Academic Presentation Hour: 9:30 a.m. - 10:30 a.m. Medical Center, Amsterdam, The Netherlands CME/CE Hours: 1 Learning Objective: Evaluate the ability of CRP to predict major CV events in statin-treated coronary patients, and the effect of 1273-341 Protective Effect of Ischemic Preconditioning on intensive lipid lowering therapy on this relationship Ischemia/Reperfusion Induced Microvascular Obstruction Determined by On-line Measurements Angiotensinogen M235T Gene Variants Affect 1272-336 of Coronary Pressure and Blood Flow in Pigs

Vascular Disease Vascular Endothelial Function And Arterial Stiffness In Patients With Essential Hypertension Mariann Gyongyosi, Aniko Posa, Rayyan Hemetsberger, Zsolt Petrasi, Ors Petnehazy, Kurt Huber, Dietmar Glogar, Medical University of Emmanouil Androulakis, Dimitris Tousoulis, Evaggelos Vienna, Vienna, Austria, University of Kaposvar, Kaposvar, Hungary Chatzistamatiou, Nikolaos Papageorgiou, George Moustakas, Antigoni Miliou, Evaggelos Oikonomou, Gerasimos Siasos, Learning Objective: identify microvascular obstruction after Anastasios Giolis, Ioannis Kallikazaros, Christodoulos Stefanadis, reopening of the infarct-related artery 1st Cardiology Unit, Hippokration Hospital, Athens, Greece Carriers of LCAT Gene Mutations Exhibit Increased Learning Objective: Investigate the impact of this polymorphism 1273-342 Atherosclerosis: A 3.0 Tesla MRI Study on the prevalence of essential hypertension (EH) and on vascular properties, such as arterial stiffness and endothelial function. Raphael Duivenvoorden, Adriaan G. Holleboom, Bas van den Bogaard, Eric de Groot, Aart J. Nederveen, Johan S. Lameris, John 1272-337 Effect of Phosphodiesterase Type 5 (PDE-5) JP Kastelein, Jan A. Kuivenhoven, Erik SG Stroes, Academic Medical Inhibition on Coronary Microvascular Dysfunction Center, Amsterdam, The Netherlands in Women: An Ancillary Study From the NHLBI- Learning Objective: recognize that LCAT is a key regulator of HDL Sponsored Women’s Ischemia Syndrome Evaluation metabolism and this enzyme plays a crucial role in protecting the (WISE) human vasculature from atherogenesis. Scott J. Denardo, Sheron Wen, Eileen M. Handberg, Anthony A. Bavry, R. David Anderson, Karen M. Smith, C. Noel Bairey-Merz, 1273-344 WITHDRAWN George Sopko, Rhonda M. Cooper-DeHoff, Carl J. Pepine, University 1273-345 Viral Anti-inflammatory Proteins Reduce of Florida, Gainesville, FL Accelerated Atherosclerosis in ApoEnull mice with Learning Objective: have an understanding of the potential effect of Periodontal Bacterial Infection and Angioplasty Sildenafil on microvascular dysfunction in women. Injury

Prediction of Cardiovascular Events in Statin-treated Alexandra R. Lucas, Raj K. Verma, Liying Liu, Erbin Dai, Ganesh 1272-339 Munuswamy-Ramanujam, Jennifer Kim, Sheela Pola, Sheela Pola, Stable Coronary Patients with Metabolic Syndrome Lakshmyya Kesavalu, University of Florida, Gainesville, FL by 18 Novel Biomarkers: The Treating to New Targets (TNT) Trial Learning Objective: evaluate a potential role for periodonatl infection in atherosclerotic plaque growth Prakash C. Deedwania, on behalf of the TNT Investigators, VACCHCS/UCSF School of Medicine, Fresno, CA 1273-346 Effects of Telmisartan and Resveratrol on Monocyte Learning Objective: Evaluate the ability of 18 novel biomarkers to Adhesion to the Endothelium Exposed to Disturbed predict the risk of major cardiovascular events among stable CHD Flow and Inflammation patients with metabolic syndrome Christoph D. Garlichs, Katharina Urschel, Werner Daniel, Iwona Cicha, University Hospital Erlangen, Department of Cardiology and Genome-wide association of Coronary Artery 1272-340 Angiology, Erlangen, Germany Disease Learning Objective: Describe that telmisartan and resveratrol David Seo, Pascal J. Goldschmidt-Clermont, Kara Hamilton, decrease the inflammation-induced recruitment of monocytic cells Margaret Pericak-Vance, Gary Beecham, University of Miami School and the endothelial expression of adhesion molecules in regions of of Medicine, Miami, FL non-uniform shear stress Learning Objective: identify gene variants associated with coronary artery disease JACC March 9, 2010 ABSTRACTS: Vascular Disease A175

1273-347 Immune-modulation by Polyclonal IgM Treatment 1274-353 The Levels and Cellular Origins of Procoagulant Reduced Atherosclerosis in Hypercholesterolemic Microparticles within the Culprit Coronary Artery of Apolipoprotein E-/- Mice Patients with Acute Myocardial Infarction

Paul C. Dimayuga, Fernando HY Cesena, Juliana Yano, Jonathan Pil-Ki Min, Sung-Yu Hong, Hee-Sun Mun, Sung-Joo Lee, Jong Kwan

Kirzner, Xiaoning Zhao, Xiaojun Li, Portia Trinidad, Bojan Cercek, Park, Jong-Youn Kim, Byoung Kwon Lee, Bum-Kee Hong, Se- Vascular Disease Prediman K. Shah, Kuang-Yuh Chyu, Cedars-Sinai Heart Institute, Joong Rim, Kwang-Hoe Chung, Hyuck Moon Kwon, Hyun Seung Los Angeles, CA Kim, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea Learning Objective: identify immune parameters in atherosclerotic disease that are modulated by polyclonal IgM treatment Learning Objective: evaluate the levels and cellular origins of microparticles within the culprit coronary artery of patients with 1273-348 Dipeptidyl Peptidase-4 Inhibitor, Saxagliptin, Enhances acute myocardial infarction Nitric Oxide Bioavailability in Aortic and Renal Endothelium From Obese, Insulin-Resistant Rats 1274-354 Increased Cysteine level is associated with Recurrent Atherothrombotic Events after Acute Richard Preston Mason, Ruslan Kubant, Adam M. Jacoby, Robert F. Coronary Syndromes Jacob, Aouatef Bellamine, Yoshiko Mizuno, Tadeusz Malinski, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA Jeroen Jaspers Focks, Nick Clappers, Marc A. Brouwer, Etiënne G. Cramer, Eveline G. van Dijk, Martijn G. van Oijen, Jan B. Jansen, Learning Objective: understand the effect of DPP4 inhibition with Wilbert HM Peters, Freek W. Verheugt, Radboud University Nijmegen saxagliptin on reversing endothelial dysfunction in animals with Medical Centre, Nijmegen, The Netherlands diabetes Learning Objective: Describe the predictive effect of cysteine on recurrent atherothrombotic events. 1274 BIOMAKERS AND VASCULAR DISEASE 2 Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. 1274-356 Behavior of Biomarkers Linking Inflammation and Thrombosis in the Infarct-related Coronary Georgia World Congress Center, Hall B5 Artery and Systemic Circulation after Primary Presentation Hour: 9:30 a.m. - 10:30 a.m. Percutaneous Coronary Intervention for the CME/CE Hours: 1 Treatment of ST-segment Elevation Myocardial Infarction 1274-350 Decreased Plasma Adiponectine Levels in Asymptomatic Diabetic Patients with Obstructive Tomomi Koizumi, Tetsuo Yamasaki, Shinichiro Iida, Toshihiko Coronary Disease Kikutani, Shigeyuki Nishimura, Nobuyuki Komiyama, Saitama International Medical Center, Saitama, Japan Roxana Djaberi, Joanne D. Schuijf, Cornelis J. Roos, Alberto M. Pereira, Jan W. Smit, Arthur J. Scholte, Johannes A. Romijn, Ernst Learning Objective: identify time course of biomarkers of thrombus E. van der Wall, Jeroen J. Bax, J. Wouter Jukema, Leiden University and inflammation after acute myocardial infarction Medical Center, Leiden, The Netherlands 1274-357 The LDL To HDL Cholesterol Ratio As A Valuable Learning Objective: Interpret the the Value of Plasma Adiponectine Parameter To Evaluate The Development Of CKD in Predisposing Coronary Artery Disease in Asymptomatic Patients with Type 2 Diabetes Takaaki Sakai, Keijiro Saku, Koichi Ide, College of Healthcare Management, Miyama, Japan, St.Mary’s Hospital, Kurume, Japan 1274-351 Nitric Oxide Donation From The Cinod Naproxcinod Counteracts Cyclooxygenase Inhibition-dependent Contraction In Human Mammary Arteries 1275 ANGIOGENEIS Manlio Bolla, Alessandra Poggi, Barbara Vergani, Guido Gelpi, Julio Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Padron, Daniela Miglietta, NicOx Research, Milan, Italy, NicOx SA, Sophia Antipolis, France Georgia World Congress Center, Hall B5 Presentation Hour: 9:30 a.m. - 10:30 a.m. Learning Objective: Understand the role of NO donation from CME/CE Hours: 1 naproxcinod in the control of vascular tone in arteries with endothelial dysfunction 1275-358 Intravenous Endothelial-like Cells Differentiated From Mesenchymal Stem Cells Accelerate Re- 1274-352 Association of Serum Concentration of Bilirubin with Coronary Endothelial Function; the endothelization In Balloon-injured Rat Relationship between Bilirubin and Oxidative Ki-Chul Hwang, Min-Ji Cha, Heesang Song, Byeong-Wook Song, Stress, Inflammatory Mediator and Lipid/Glucose Eunju Choi, Onji Ham, Namsik Chung, Yangsoo Jang, Ki-Chul Hwang, Metabolism Cardiovascular Research Institute, Division of Cardiology, Yonsei University College of Medicine, Seoul, South Korea Satoshi Yoshino, Shuichi Hamasaki, Sanemasa Ishida, Tetsuro Kataoka, Akiko Yoshikawa, Naoya Oketani, Keishi Saihara, Takuro Takumi, Chuwa Tei, Department of Cardiovascular, Respiratory and Metabolic Medicine, Kagoshima University, Kagoshima, Japan Learning Objective: describe the association of serum concentration of bilirubin with coronary endothelial function A176 ABSTRACTS: Vascular Disease JACC March 9, 2010

1275-359 CD271 Identifies Human Bone Marrow Stem/ 1276-365 Self Assembling Peptide Amphiphile Nanofibers As Progenitor Cells with a Proangiogenic Potential and A Scaffold For Endothelial Progenitor Cells Circulating Progenitor Cells Mobilized after Acute Alberto Balbarini, Angela Magera, Maria Chiara Barsotti, Hossein Myocardial Infarction Hosseinkhani, Federica Chiellini, Roberto Solaro, Rossella Di Yoshitaka Iso, Jeffrey L. Spees, Takatoshi Sato, Shinji Koba, Youichi Stefano, Cardiac, Vascular and Thoracic Department, University of Kobayashi, Yoichi Takeyama, Hiroshi Suzuki, Division of Cardiology, Pisa, Pisa, Italy, Department of Chemistry and Industrial Chemistry, Showa University Fujigaoaka Hospital, Yokohama, Japan University of Pisa, Pisa, Italy Learning Objective: identify that CD271(+) MSCs are recruited into Learning Objective: identify new possibilities in ischemic tissue peripheral blood after acute MI in response to myocardial damage regeneration and are one of the promising cell sources in angiogenic cell

Vascular Disease Vascular therapies. 1276-366 Potential Role of Pentraxin 3 (PTX3) in Advanced Coronary Atherosclerosis: Coronary Rotational 1275-360 Differential Expression of the Hypoxia Target Atherectomy Study Genes in Porcine Marrow Stromal Cells After Hironobu Akao, Michihiko Kitayama, Yasuyuki Kawai, Ryoko Sato, Transplantation into Ischemic Myocardium Atsushi Motoyama, Minoru Wakasa, Hirofumi Aoki, Ryuhei Saito, Yifu Zhou, Suna Wang, Caleb N. Seavey, Robert F. Hoyt, Jr, Timothy Kosuke Fujibayashi, Kouji Kajinami, Kanazawa Medical University, Hunt, Keith A. Horvath, National Institutes of Health, Bethesda, MD Uchinada, Japan Learning Objective: The roles of ischemic target genes in the Learning Objective: atherosclerosis myocardial ischemic tissues after stem cell treatment 1276-367 Dual CT and MRI In vivo Tracking of Stem Cell 1275-361 Determinants of Collateral Circulation in Patients Therapy in Peripheral Artery Disease with Documented Coronary Occlusion: The Case for Yibin Xie, Yingli Fu, Ronald Ouwerkerk, Steven M. Shea, Tina Gender and Smoking Ehtiati, Dorota Kedziorek, Gary Huang, Wesley D. Gilson, Meiyappan Eric Van Belle, Sophie Susen, François J. Cuilleret, Frédéric Solaiyappan, Robert Krieg, Dara L. Kraitchman, Johns Hopkins Mouquet, Pierre V. Ennezat, Thierry Letourneau, Pieter A. University, Baltimore, MD Doevendans, Jean Dallongeville, Michel E. Bertrand, Brigitte Jude, Learning Objective: demonstrate that APA microcapsules containing CHRU, Lille, France, UMC, Utrecht, The Netherlands PFOB provide a reliable method for tracking therapeutic stem cells Learning Objective: identidy that in patients with coronary occlusion, in vivo by both CT and MRI collateral circulation is impaired in women and in smokers 1276-368 Significant Down-regulation of the Anti- 1275-362 Overexpressing Cellular repressor of E1A-stimulated inflammatory Cytokine Interleukin-10 is Genotype genes Protects Mesenchymal Stem Cells Against Dependent in Atherosclerotic Plaques with Intra- Hypoxia- and Serum Deprivation-Induced Apoptosis plaque Hemorrhage by Activation of PI3K/Akt Pedro R. Moreno, K-Raman Purushothaman, Meerarani Yaling Han, Jie Deng, Chenhui Yan, Xiaoxiang Tian, Jie Tao, Jian Purushothaman, Prakash Krishnan, Patrick A. Lento, John T. Fallon, Kang, Shaohua Li, Shenyang Northern Hospital, Shenyang, People’s Annapoorna S. Kini, Samin K. Sharma, Andrew P. Levy, Valentin Republic of China Fuster, Mount Sinai Medical Center, New York, NY, New York, NY Learning Objective: Demonstrate Learning Objective: Identify the anti-inflammatory cytokine IL10 significance in Haptoglobin Genotypes.

1276 VASCULAR--PATHOPHYSIOLOGY AND BIOLOGY 1277 ATHEROSCLEROTIC RISK FACTORS -- Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. PATHOPHYSIOLOGY—CLINICAL Georgia World Congress Center, Hall B5 Tuesday, March 16, 2010, 9:30 a.m. - 12:30 p.m. Presentation Hour: 9:30 a.m. - 10:30 a.m. Georgia World Congress Center, Hall B5 CME/CE Hours: 1 Presentation Hour: 9:30 a.m. - 10:30 a.m. 1276-364 Difference In Neuregulin Levels And The Severity Of CME/CE Hours: 1 Coronary Artery Disease 1277-370 Posttraumatic Stress Disorder is Associated with Carrie Anna Geisberg, Brian Veerkamp, Guisong Wang, Radwan Higher C-Reactive Protein Levels Safa, Holly Smith, Yenya Hu, David Zhao, Douglas Sawyer, Vanderbilt Medical University, Nashville, TN, Peking University Third Hospital, Viola Vaccarino, J. Douglas Bremner, Nadeem Afzal, Emir Veledar, Beijing, People’s Republic of China Jack Goldberg, Emory University, Atlanta, GA Learning Objective: Interpret the relationship between neuregulin Learning Objective: Demonstrate understanding that the link and severity of coronary artery disease between posttraumatic stress disorder and CVD may occur through inflammatiory processes. JACC March 9, 2010 ABSTRACTS: Vascular Disease A177

1277-371 Biomarkers of coronary atherosclerosis versus peripheral arterial disease in type 2 Diabetes Mellitus

Luis H. Eraso, Naeema Ginwala, Atif N. Qasim, Nehal N. Mehta,

Muredach P. Reilly, Unniversity of Pennsylvania, Cardiovascular Vascular Disease Institute, Philadelphia, PA Learning Objective: Understand risk factor differences between coronary artery disease and peripheral arterial disease in diabetes type-2

1277-372 Heavy Metals And Cardiovascular Disease: Results From Nhanes 1999-2006

Shikhar Agarwal, E. Murat Tuzcu, Samir R. Kapadia, Cleveland Clinic, Cleveland, OH Learning Objective: Evaluate association between heavy metal exposure and cardiovascular and cerebrovascular disease

1277-373 Vitamin D Levels Are Not Related to Myalgias in Statin-Treated Patients with Stable Coronary Disease

Vera Bittner, Nanette K. Wenger, David D. Waters, David A. DeMicco, Michael Messig, John C. LaRosa, University of Alabama at Birmingham, Birmingham, AL, Emory University, Atlanta, GA Learning Objective: Evaluate the effect of serum vitamin D levels on myalgia incidence in statin-treated patients with stable coronary heart disease

1277-374 Cardiovascular Risk in Type 2 Diabetes Mellitus: The Role of an Unusual T-Cell Population simona giubilato, Salvatore Brugaletta, Costantino Smaldone, Vincenzo Pazzano, Dario Pitocco, Giovanni Ghirlanda, Luigi M. Biasucci, Giovanna Liuzzo, Filippo Crea, Catholic University of the Sacred Heart, Rome, Italy Learning Objective: evaluate the correlation between CD4CD28null T cells and cardiovascular risk in patients with type 2 diabetes mellitus A178 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

ORAL CONTRIBUTIONS

2901 VALVULAR INTERVENTIONS 9:00 Percutaneous Mitral Valvuloplasty During Pregnancy Sunday, March 14, 2010, 8:00 a.m. - 9:30 a.m. Hung Manh Pham, Oanh T.N. Pham, Heart Insitute, Hanoi, Viet Nam, Ducgiang Hospital, Hanoi, Viet Nam Georgia World Congress Center, Room B308 CME/CE Hours: 1.5 Learning Objective: Describes the experience in pregnant mitral stenosis patients undergoing valvuloplasty using the Inoue balloon with echo online 8:00 MSCT Derived Preprocedural Parameters to Predict Clinical Outcome of Percutaneous Aortic Valve Replacement 2902 IMAGING AND VULNERABLE PLAQUE Alexander Leber, Markus Kasel, Diethmar Antoni, Ellen Hoffmann, Sunday, March 14, 2010, 8:00 a.m. - 9:30 a.m. Thomas Ischinger, Heart Center Munich Bogenhausen, aff. with Georgia World Congress Center, Room B310 University of Munich, Munich, Germany CME/CE Hours: 1.5 Learning Objective: learn about percutaneous valve implantation and Cardiac Ct 8:00 Relationship Between Coronary Calcium Score i2 Summit by Cardiac Computed Tomography Angiography 8:12 Pulmonary Hypertension in Patients with Severe and Plaque Components by Virtual Histology- Aortic Stenosis: Clinical Profile, Prognostic Intravascular Ultrasound (Interventional Cardiology) Implication and Response to Transcatheter Aortic Implantation Young Joon Hong, Yun Ha Choi, Myung Ho Jeong, Eun Hye Ma, Keun Ho Park, Doo Sun Sim, Jum Suk Ko, Min Goo Lee, Ju Han Itsik Ben-Dor, Steven A. Goldstein, Augusto D. Pichard, Lowell F. Satler, Kim, Youngkeun Ahn, Jung Chaee Kang, Heart Center of Chonnam Rebecca Torguson, Petros Okubagzi, Zhenyi Xue, Yanlin Li, Asmir I. National University Hospital, Gwangju, South Korea Syed, Zuyue Wang, Manuel A. Gonzalez, Michael A. Gaglia, Gabriel Learning Objective: to evaluate the relationship between coronary Maluenda, Kohei Wakabayashi, Cedric Delhaye, Nicholas N. Hanna, calcium score and plaque components Sara D. Collins, William O. Suddath, Kenneth M. Kent, Joseph Lindsay, Ron Waksman, Washington Hospital Center, Washington, DC, DC 8:12 Lesion-Specific Measurements on Non-Contrast- Learning Objective: To investigate incidence, predictors and Enhanced Coronary CT Strongly Correlate with prognostic implication and the impact of Trans catheter aortic valve Plaque Burden and Luminal Size by Intravascular implantation on pulmonary hypertension in patients with severe Ultrasound aortic stenosis Jesus Gustavo Vazquez Figueroa, Parag H. Joshi, Eric Krivitsky, 8:24 Mechanisms of Early Improvement of Secondary Sarah Rinehart, Zhen Quian, Ayesha Shaukat, Idean B. Marvasty, Mitral Regurgitation After Transcatheter Aortic Valve Szilard Voros, Piedmont Heart Institute, Atlanta, GA Replacement Learning Objective: Demonstrate the correlation between lesion specific calcium score and geometrical parameters by intravascular Claudiu Stoicescu, Mariuca Vasa Nicotera, Derek Chin, Dragos ultrasound. Vinereanu, Jan Kovac, University Of Medicine and Pharmacy Carol Davila, Bucharest, Romania, University Hospitals of Leicester, Leicester, United Kingdom 8:24 Are Vulnerable Plaques Widely Disseminated or Focal? A Baseline 3-Vessel IVUS Analysis from the Learning Objective: evaluate effects of transcatheter aortic PROSPECT Trial replacement on functional mitral regurgitation associated with aortic stenosis John A. McPherson, Akiko Maehara, Gary S. Mintz, Alexandra J. Lansky, Ecaterina Cristea, Barry Templin, Roxana Mehran, George 8:36 Transcatheter Aortic Valve Implantation Preserves Dangas, Zhen Zhang, Bertil Wennerblom, Andres Iniguez, Jean Mitral Valve 3D Geometry Better than Standard AVR Fajadet, Michael Foster, Bernard de Bruyne, Patrick W. Serruys, Gregg W. Stone, Vanderbilt Heart and Vascular Institute, Nashville, Mathieu Vergnat, Joseph Bavaria, Benjamin M. Jackson, Albert T. TN, Columbia University Medical Center and the Cardiovascular Cheung, Stuart J. Weiss, Joseph H. Gorman III, Robert C. Gorman, Research Foundation, New York, NY University of Pennsylvania, Philadelphia, PA Learning Objective: Describe the prevalence and distribution of Learning Objective: demonstrates effect of aortic procedure on vulnerable plaques identified by intravascular ultrasound in patients mitral annulus geometry presenting with acute coronary syndromes.

8:48 Complications and Outcomes of Balloon Aortic 8:36 Micro-channel Structure Identified by Optical Valvuloplasty in High-Risk or Inoperable Patients Coherence Tomography Is Related to Plaque Itsik Ben-Dor, Augusto D. Pichard, Lowell F. Satler, Yanlin Li, Asmir I. Syed, Vulnerability in Patients with Coronary Artery Disease Gabriel Maluenda, Manuel A. Gonzalez, Sara D. Collins, Cedric Delhaye, Hironori Kitabata, Kohei Ishibashi, Kenichi Komukai, Takashi Michael A. Gaglia, Kohei Wakabayashi, Nicholas N. Hanna, Rebecca Tanimoto, Yasushi Ino, Shigeho Takarada, Takashi Kubo, Keizo Torguson, Okubagzi Petros, Zhenyi Xue, William O. Suddath, Kenneth M. kimura, Masato Mizukoshi, Toshio Imanishi, Takashi Akasaka, Kent, Ron Waksman, Washington Hospital Center, Washington DC, DC Wakayama medical university, Wakayama, Japan Learning Objective: To determine the success, complication and Learning Objective: identify the imaging marker of plaque survival of patients after balloon aortic valvuloplasty vulnerability to improve patient risk stratification. JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A179

8:48 Vulnerability of Left Main Plaques by Virtual 2:36 Impact of Chronic Kidney Disease on Platelet Histology Intravascular Ultrasound Function Profiles in Diabetes Mellitus Patients with Coronary Artery Disease on Dual Antiplatelet Steven P. Marso, Tabitha G. Moe, John A. House, William J. Dolla, Therapy Lindsey Seifert, Jason B. Lindsey, Kevin F. Kennedy, Michel Pieper, Mid America Heart Institute, Kansas City, MO, AKH / Vienna General Davide Capodanno, Esther Bernardo, David Vivas, Jose’ Luis Hospital, Vienna, Austria Ferreiro, Manel Sabate’, Pilar-Jimenez Quevedo, Masafumi Ueno, Learning Objective: Describe differences in plaque burden and Kodlipet Dharmashankar, Fernando Alfonso, Theodore Bass, Carlos composition between the left main and proximal coronary arteries Macaya, Antonio Fernandez-Ortiz, Dominick J. Angiolillo, University of Florida College of Medicine, Jacksonville, FL

9:00 Association of Large Lipid Core Plaque Detected by Learning Objective: Demonstrate the impact of renal function on Cardiology) (Interventional Near Infrared Spectroscopy with Post Percutaneous platelet function Coronary Intervention Myocardial Infarction

2:48 Safety and Outcomes of Bivalirudin in Dialysis i2 Summit Brijeshwar Maini, Emmanouil S. Brilakis, Michael Kim, Michael J. Patients Undergoing Percutaneous Coronary Hendricks, Stephen T. Sum, Sean P. Madden, James E. Muller, David Intervention Rizik, Simon R. Dixon, Moffitt Heart & Vascular Group, Harrisburg, PA, Dallas VARC, Dallas, TX Cedric Delhaye, Gabriel Maluenda, Kohei Wakabayashi, Itsik Ben- Learning Objective: identify patients with a lipid core plaque who Dor, Sara D. Collins, Asmir I. Syed, Manuel A. Gonzalez, Michael A. may be at risk for a post-PCI AMI. Gaglia, Rebecca Torguson, Zhenyi Xue, William O. Suddath, Lowell F. Satler, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard, Ron Waksman, Washington, DC 2903 INTERVENTIONAL PHARMACOLOGY Learning Objective: A dose adjusted BIV anticoagulation regimen in Sunday, March 14, 2010, 2:00 p.m. - 3:30 p.m. CDP undergoing PCI seems to be as safe and as effective as UFH use alone. Georgia World Congress Center, Room B315 CME/CE Hours: 1.5 3:00 Impact of Antithrombotic Regimen and Troponin Status on Outcomes of Percutaneous Coronary Impact of Platelet Reactivity on Clinical Outcomes: 2:00 Intervention in Acute Coronary Syndromes: The A Patient Level Meta-Analysis Acuity Trial Somjot Brar, Giuseppe Patti, Matthew J. Price, Rossella Marcucci, So-Yeon Choi, Eugenia Nikolsky, Alexandra J. Lansky, Roxana Thomas Cuisset, George Dangas, Kaiser Permanente, Los Angeles, Mehran, Akiko Maehara, Brent T. McLaurin, David A. Cox, Frederick CA, Columbia University Medical Center, New York, NY Feit, Gregg W. Stone, Columbia University Medical Center and the Learning Objective: Demonstrate the impact of platelet reactivity on Cardiovascular Research Foundation, New York, NY clinical outcomes Learning Objective: evaluate

2:12 Impact of Clopidogrel Pretreatment on Ischemic Complications of PCI Among Bivalirudin-Treated 2904 NEW TECHNOLOGIES Patients: Results from the EVENT Registry Sunday, March 14, 2010, 4:30 p.m. - 6:00 p.m. Amit P. Amin, Kevin Kennedy, Michael Pencina, Peter Berger, Robert Georgia World Congress Center, Room B315 N. Piana, John Lopez, Neil Kleiman, David J. Cohen, St. Luke’s Mid- CME/CE Hours: 1.5 America Heart Institute, University of Missouri, Kansas City, MO Learning Objective: To recognize the impact of clopidogrel 4:30 Very Long-term Results (> 2 Year) of the Vestasync pretreatment on ischemic complications of PCI among bivalirudin- I Trial with a Novel, Third-generation, Hydroxyapatite treated elective PCI patients Polymer-free Sirolimus-eluting Stent

2:24 Six-Month Outcomes with or without Proton-Pump Jose de Ribamar Costa, Jr., Alexandre Abizaid, Ricardo Costa, Inhibitors after Successful PCI: Insights from the Fausto Feres, Andrea Abizaid, Luiz Fernando Tanajura, Dimytri Guthrie PCI Registry Siqueira, Rodolfo Staico, Galo Maldonado, Amanda Sousa, J Eduardo Sousa, Instituto Dante Pazzanese de Cardiologia, São Kishore J. Harjai, Chetan Shenoy, Pam Orshaw, Judy Boura, Guy Paulo, Brazil Rogers, Guthrie Health System, Sayre, PA Learning Objective: Demonstrate the very long term results of the Learning Objective: Describe impact of use of PPI on outcomes after PCI first-in-man evaluation of the novel non-polymeric MIV-sirolimus- eluting stent A180 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

4:42 Final Results of the INSPIRE trial with the Novel 2905 ENDOVASCULAR INTERVENTIONS MGuard Stent System Containing a Protection Net to Prevent Distal Embolization Monday, March 15, 2010, 8:00 a.m. - 9:30 a.m. Georgia World Congress Center, Room B315 Jose de Ribamar Costa, Jr., Alexandre Abizaid, Ricardo Costa, CME/CE Hours: 1.5 Felipe Maia, Fausto Feres, Rodolfo Staico, Dimytri Siqueira, Galo Maldonado, Luiz Fernando Tanajura, Renata Viana, Juliana Castro, Amanda Sousa, J Eduardo Sousa, Instituto Dante Pazzanese de 8:00 Influence of Lesions Characteristics on Thirty-day Cardiologia, São Paulo, Brazil, Cardiovascular Research Center, São Outcomes after Carotid Artery Stenting from the Paulo, Brazil SAPPHIRE Worldwide Registry Learning Objective: Demonstrate the feasibility of a novel net- Christopher Metzger, Farrell Mendelsohn, Maurice Solis, Donald containing BMS stent dedicated to the treatment of thrombus Heck, William Bachinsky, Greg Schultz, Holston Valley Medical containing lesions Center, Kingsport, TN, Baptist Medical Center, Birmingham, AL Learning Objective: identify lesion characteristics associated with a 4:54 Mitral Annular Reduction with Subablative High higher degree of adverse events after carotid stenting Intensity Focused Ultrasound: Safety, Efficacy and Dose Response in an Animal Model 8:15 Percutaneous Endovenous Intervention Reduces i2 Summit Hasan Jilaihawi, Renu Virmani, Hiroshi Nakagawa, Anique Post Thrombotic Syndrome and Recurrent Venous Ducharme, Yan Fen Shi, Yong Zou, Atsushi Ikeda, Anita Asgar, Raoul Thromboembolic Disease in Acute Deep Venous Bonan, Montreal Heart Institute, Montreal, Canada Thrombosis (Interventional Cardiology) Learning Objective: Describe the novel technique of HIFU mitral Mohsen Sharifi, Mahshid Mehdipour, Adam Berkovits, Gary Smith, annular reduction and interpret its effects from animal model data. Arizona Cardiovascular Consultants, Mesa, AZ, A.T.Still University, Mesa, AZ Prevalence and Clinical Impact of Coronary 5:06 Learning Objective: Recognize that early percutaneous endovenous Artery Aneurysm after Sirolimus-eluting Stent intervention significantly reduces the incidence of post-thrombotic Implantation: Long-term Clinical and Angiographic syndrome Follow-up

Masao Imai, Kazushige Kadota, Suguru Otsuru, Yoji Okamoto, 8:30 Renal Artery Plaque Composition Is Associated with Hiroshi Tasaka, Daiji Hasegawa, Seiji Habara, Hiroyuki Tanaka, Change In Renal Perfusion Following Renal Artery Takeshi Maruo, Akitoshi Hirono, Yoshiharu Nishibori, Shingo Hosogi, Stenting Yasushi Fuku, Naoki Oka, Harumi Katoh, Hiroyuki Yamamoto, Satoki Anand Prasad, Patrick Hu, Nayab M. Zafar, Anita N. Majabo, Kelly Fujii, Tsuyoshi Goto, Katsumi Inoue, Kazuaki Mitsudo, Kurashiki A. Enright, Vachaspathi Palakodeti, Sotirios Tsimikas, Ehtisham Central Hospital, Kurashiki, Japan Mahmud, University of California San Diego, San Diego, CA Learning Objective: Coronary artery aneurysm after sirolimus-eluting Learning Objective: Describe the relationship between renal artery stent tend to increase the size plaque compostion and its relationship to renal perfusion following renal artery stenting. 5:18 Long-Term Clinical Outcome of a Real World Experience in Patients Treated with a GenousTM EPC 8:45 Stent Fracture, TASC II CD Lesion as Restenosis Capturing Stent Factors, and Cilostazol as a Negative-restenosis Margo Klomp, Marcel A. Beijk, Karel T. Koch, Jose P. Henriques, Factor within a Year Following Nitinol Stent Jan Baan, Marije M. Vis, Jan G. Tijssen, Jan J. Piek, Robbert J. Implantation in the Superficial Femoral Artery de Winter, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands Osamu Iida, Msaaki Uematsu, Seiki Nagata, Yoshimitsu Soga, Hiroyoshi Yokoi, Masakiyo Nobuyoshi, Keisuke Hirano, Toshiya Learning Objective: interpret the value of the EPC capturing stent in Muramatsu, Shinsuke Nanto, Kansai Rosai Hospital, Amagasaki, an unselected patient population Japan Learning Objective: demonstrate the factors associated with Impact of Tandem Heart Percutaneous Left 5:30 restenosis occurring within a year following nitinol stent Ventricular Assist Device on Invasive Hemodynamics implantation in the superficial femoral artery. Inder M. Singh, David R. Holmes, Jr., Charanjit S. Rihal, Mayo Clinic (Cardiac Catheterization Laboratory), Rochester, MN 9:00 Does Location Matter? Improvement in Quality of Life for Patients Undergoing Percutaneous Vascular Learning Objective: Evaluate the impact of Tandem Heart Interventions, Insights from the Blue Cross Blue percutaneous left ventricular assist device on invasive hemodynamics in inoperable patients undergoing high risk PCI. Shield of Michigan Cardiovascular Consortium Paul Michael Grossman, Samuel R. Kaufman, David Share, Herbert D. Aronow, Stanley J. Chetcuti, Paul Bove, Timothy J. Nypaver, James M. Fox, M. Ashraf Mansour, Hitinder S. Gurm, University of Michigan Hospitals and Health Center, Ann Arbor, MI Learning Objective: describe the singnificant impairment in quality of life of patients with severe lower extremity PAD, and understand the sustained improvement after percutaneous intervention. JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A181

2906 LEFT MAIN DISEASE 3:00 Feasiblity and Safety of Hybrid Revascularization for Left Main Coronary Artery Stenosis Monday, March 15, 2010, 2:00 p.m. - 3:30 p.m. Georgia World Congress Center, Room B315 S. Tanveer Rab, John S. Douglas,Jr., Ellen Lyons, Thomas A. Vassiliades, Jr., Emory University School of Medicine, Atlanta, GA CME/CE Hours: 1.5 Learning Objective: Learn a new approach in treating Left Main 2:00 Drug-Eluting Stents for the Treatment of Left Main Coronary artery stenosis. Coronary Artery Disease with Sirolimus, Paclitaxel, Zotarolimus, BiolimusA9, EPC Capture and 2907 STRUCTURAL HEART DISEASE INTERVENTIONS Everolimus-Eluting Stent: Multicenter Registry in Asia Monday, March 15, 2010, 4:30 p.m. - 6:00 p.m. Cardiology) (Interventional Sunao Nakamura, Shotaro Nakamura, Hisao Ogawa, Jang-Ho Bae, Georgia World Congress Center, Room B308 Yeo Hans Cahyadi, Wasan Udayachalerm, Damras Tresukosol, CME/CE Hours: 1.5 Sudaratana Tansuphaswadikul, New Tokyo Hospital, Chiba, Japan i2 Summit Learning Objective: Describe the clinical efficacy of SES, PES, ZES, 4:30 A Novel Method for Septal Ablation: Glue BES, ECS and EES implantation in patients with left main trunk (Cyanoacrylate) Septal Ablation disease which is safe, low restenosis rate and low incidence of complication. Ali Oto, Kudret Aytemir, Sercan Okutucu, Ergün B. Kaya, Barbaros Çil, Bora PeynircioŒlu, Ali Deniz, Hikmet Yorgun, Onur S. Deveci, 2:12 Ten-Year Outcomes after Stent Implantation versus Hakan Aksoy, Lale TokgözoŒlu, Giray Kabakçı, Nasıh Nazlı, Hilmi Coronary-Artery Bypass Grafting for Unprotected Özkutlu, Hacettepe University, Ankara, Turkey Left Main Coronary Artery Disease Learning Objective: We describe a successful technique for septal ablation with cyanoacrylate in hypertrophic obstructive Duk Woo Park, Jung-Min Ahn, Won-Jang Kim, Jong-Young Lee, cardiomyopathy which decrease the complications related to alcohol Sung-Cheol Yun, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, instillation Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park, Asan Medical Center, Seoul, South Korea 4:42 Sustained Long-term Migraine Reduction after PFO Learning Objective: identify the left main coronary artery stenosis Closure

2:24 Pathology of Drug Eluting Stents and Bare Metal Daniela Trabattoni, Franco Fabbiocchi, Stefano Galli, Piero Montorsi, Stents in the Left Main Coronary Artery Giovanni Teruzzi, Alessandro Lualdi, Paolo Ravagnani, Pamela Gatto, Antonio L. Bartorelli, Centro Cardiologico Monzino, IRCCS, Milan, IL, Marc M. Vorpahl, Masataka Nakano, Gaku Nakazawa, Robert Kutys, Italy Elena Ladich, CV Path Institute, Gaithersburg, MD Learning Objective: Interpret migraine score; evaluate beneficial Learning Objective: to understand pathological differences of DES effects of PFO closure in patients with a previous TIA and and BMS in left main coronary stenting symptomatics for headache

2:36 Long-Term Clinical Outcomes of Unprotected Left Main 4:54 PROTECT AF Trial - Intermediate-Term Outcome Stenting with Sirolimus Eluting Stents: Correlation Between the SYNTAX Score and Clinical Outcomes David R. Holmes, Jr., Mayo Clinic, Rochester, MN Learning Objective: To compare the outcome of left atrial Hiroki Shiomi, Toshihiro Tamura, Yoshihiro Kato, Tomohisa Tada, appendage occlusion versus Warfarin in patients with nonvalvular Junichi Tazaki, Toshikazu Jinnai, Koh Ono, Takeshi Kimura, atrial fibrillation (PROTECT AF) at 1200 patient years versus the Department of cardiology, Kyoto university, Kyoto, Japan initial 600 patient year data. Learning Objective: interpret the efficacy of unprotected left main stenting with sirolimus eluting stents and evaluate correlation 5:06 Maximum Diameter of Atrial Septal Defect between the SYNTAX score and clinical outcomes in unprotected Measured by Live 3 Dimensional Transesophageal left main stenting Echocardiography Contributes for Appropriate Device Selection in Patients with Large Defect: 2:48 Five-Year Outcomes after Drug-Eluting Stents versus Balloon Sizing Technique Should be Avoided in Coronary-Artery Bypass Grafting in Unprotected Left Patients with Large ASD Main Coronary Artery Disease Teiji Akagi, Manabu Taniguchi, Koji Nakagawa, Yasufumi Kijima, Duk Woo Park, Jong-Young Lee, Won-Jang Kim, Junhyok Oh, Jung- Hiroshi Ito, Shunji Sano, Okayama University, Okayama, Japan Min Ahn, Haegeun Song, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park, Asan Learning Objective: Adult patients with ASD and significant TR are Medical Center, Seoul, South Korea not rare, and the majority of these patients suffered from significant congestive heart failure. Learning Objective: to identify long-term ouctomes of left main coronary artery disdease A182 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

5:18 Trans-Catheter Closure of Multi-Fenestrated Atrial 5:06 Impact of Uncovered Stent Struts on Optical Septal Defects: Comparison study of Helex vs Coherence Tomography (OCT) Detected Thrombus Cribriform Devices Formation at 10-Month Follow-up of Sirolimus- Eluting Stents (SES) Mohammed T. Numan, Muhammad Dilawar, Howaida Elsaeed, Amal ElSisi, University of Texas, Houston, TX, Hamad Hospital, Doha, Qatar Yukio Ozaki, Masanori Okumura, Tevfik F. Ismail, Kousuke Hattori, Hiroyuki Naruse, Shino C. Kan, Makoto Ishikawa, Tomoko Kawai, Learning Objective: Evaluate the difference between the Helex(Gore) Junichi Ishii, Hitoshi Hishida, Fujita Health University Hospital, and Cribriform(AGA) devices in closing Multi Fenestrated Atrial Toyoake, Japan, Charing Cross Hospital, London, United Kingdom Septal Defects. Learning Objective: This study indicated that uncovered struts could 5:30 Long Term Follow-up of Intravascular Stent play a role in the thrombus formation, furthermore, fibrin deposit Placement for Atrial Baffle Stenosis after Mustard over the strut and incomplete stent apposition would also relate to Repair for Transposition of the Great Arteries LST/VLST.

Sheetal Patel, Daniel Turner, Thomas Forbes, Peter P. Karpawich, 5:18 Prospective Application of Predefined Intravascular Children’s Hospital of Michigan, Detroit, MI Ultrasound Criteria for Revascularization of Learning Objective: know the immidiet and long term success of Intermediate Left Main Coronary Artery Lesions: i2 Summit catheter based treatment of Mustard baffle obstruction Results from the Multicentered LITRO Study

Jose M. de la Torre Hernandez, Felipe Hernandez, Fernando Alfonso,

(Interventional Cardiology) 2908 IMAGING AND STENTS Ramon Lopez Palop, Jose R. Rumoroso, Iñigo Lozano, Juan M. Ruiz Nodar, Jose A. Baz, Fina Mauri, Federico Gimeno, Jose Moreu, Monday, March 15, 2010, 4:30 p.m. - 6:00 p.m. Antonio Dominguez, Jose G. Galache, Vicki Martin, Ramon Calviño, Georgia World Congress Center, Room B310 Francisco Bosa, Armando Perez de Prado, Luis Martinez Elbal, Javier CME/CE Hours: 1.5 Botas, Jesus Jimenez Mazuecos, Cristobal Urbano, Javier Goicolea, Grupo de Trabajo Español de Diagnostico Intracoronario, Spain, Spain 4:30 Late and Very Late Drug-Eluting Stent Malapposition: A Serial Two Year Quantitative IVUS Learning Objective: Demonstrate the definite value of intracoronary Analysis ultrasound evaluation of intermediate left main coronary artery stenosis in decision of revascularization Kang Soo-Jin, Gary S. Mintz, Duk-Woo Park, Seung-Whan Lee, Young- Hak Kim, Cheol Whan Lee, Ki-Hoon Han, Jae-Joong Kim, Seong-Wook Temporal Changes of Neointimal Coverage Park, Seung-Jung Park, Asan medical center, Seoul, South Korea 5:30 and Thrombogenicity after Drug-Eluting Stent Learning Objective: malapposition Implantation; Angioscopic Comparison Between Sirolimus-eluting and Paclitaxel-eluting Stent 4:42 IVUS Predictors of Early Stent Thrombosis after Primary Percutaneous Intervention in Acute Masahiko Hara, Masami Nishino, Takeshi Masaki, Naoki Mori, Myocardial Infarction: A HORIZONS-AMI Substudy Takahiro Yoshimura, Yasuharu Lee, Daisuke Nakamura, Shinpei Nakatani, Masayuki Taniike, Nobuhiko Makino, Hiroyasu Kato, So-Yeon Choi, Bernhard Witzenbichler, Akiko Maehara, Gary S. Yasuyuki Egami, Ryu Shutta, Hitoshi Yamaguchi, Jun Tanouchi, Mintz, Alexandra J. Lansky, Giulio Guagliumi, Bruce Brodie, Mirle Yoshio Yamada, Osaka Rosai Hospital, Sakai, Japan A. Kellett, Jr, Helen Parise, Roxana Mehran, George D. Dangas, Learning Objective: understand that the temporal changes of Gregg W. Stone, Cardiovascular Research Foundation / Columbia neointimal coverage and thrombogenicity are different between University Medical Center, New York, NY sirolimus- and paclitaxel-eluting stent. Learning Objective: evaluate 2909 ACUTE MYOCARDIAL INFARCTION 4:54 Serial Changes of Tiny Stent Malapposition Not Detected by Intravascular Ultrasound: Follow-up Monday, March 15, 2010, 4:30 p.m. - 6:00 p.m. Optical Coherence Tomography Study Georgia World Congress Center, Room B315 Won Ho Kim, Myeong-Ki Hong, Jaemin Shim, Jung-Sun Kim, Young- CME/CE Hours: 1.5 Guk Ko, Donghoon Choi, Yangsoo Jang, Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, 4:30 Impact of Paclitaxel-Eluting Stents in Diabetic Seoul, SC, South Korea Patients with Acute Myocardial Infarction Learning Objective: This study demonstrates that tiny stent Undergoing Primary Angioplasty: Analysis from the malapposition which is not detectable by IVUS may disappear or HORIZONS AMI trial decrease in follow up OCT evaluation. It may be stable and likely Bernhard Witzenbichler, Jochen Woehrle, Giulio Guagliumi, Jan represent a benign phenomenon. Peruga, Bruce Brodie, Dariusz Dudek, Ran Kornowski, Franz Hartmann, Helen Parise, Alexandra Lansky, Eugenia Nikolsky, Roxana Mehran, Gregg Stone, Charite - Campus Benjamin Franklin, Berlin, Germany Learning Objective: describe the impact of paclitaxel-eluting stents on outcome in the treatment of STEMI patients JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A183

4:42 Four Year Survival after Percutaneous Coronary 2910 DES Intervention with Drug Eluting Stents and Bare Metal Stents in Patients with Acute Myocardial Tuesday, March 16, 2010, 8:00 a.m. - 9:30 a.m. Infarction. A New Jersey Statewide Database Study. Georgia World Congress Center, Room B315 CME/CE Hours: 1.5 Tudor Dumitru Vagaonescu, Abel E. Moreyra, Alan C. Wilson, Nora M. Cosgove, John B. Kostis, UMDNJ Robert Wood Johnson Med Two-Year Graft Occlusion and Stent Thrombosis Sch, New Brunswick, NJ 8:00 in Patients with De Novo Left Main and/or Three Learning Objective: Use of DES versus BMS in the setting of AMI PCI Vessel Disease: Analysis from the SYNTAX Trial

4:54 Safety and Efficacy of Transradial versus Ted Feldman, Michael J. Mack, Antonio Colombo, Friedrich W. Mohr, Cardiology) (Interventional Transfemoral Coronary Intervention in Acute Patrick W. Serruys, A. Pieter Kappetein, Thomas McGarry, Scott Myocardial Infarction: A Meta-Analysis of K. Lucas, Andrea D’Armini, Ezio Bramucci, Katrin Leadley, Keith D.

Dawkins, Evanston Northwestern Healthcare, Evanston, IL, Boston i2 Summit Randomized Trials Scientific Corporation, Natick, MA Param P. Singh, Updesh S. Bedi, Mukesh Singh, Sasikanth Learning Objective: explain the incidence of very late stent Adigopula, Vamsi Kodumuri, Amol Bahekar, Ankur Sethi, Janos thrombosis or graft occlusion through 2 years in a high-risk Molnar, Rohit Arora, Sandeep Khosla, Chicago Medical School/ population of patients with LM and/or 3VD disease who were RFUMS, North Chicago, IL revascularized with either PCI or CABG Learning Objective: Demonstrate safety and efficacy of transradial coronary intervention in acute myocardial infarction. 8:12 Long-term Outcomes of Drug-Eluting Stents for Off- label Indications: A Report from the NHLBI Dynamic 5:06 Impact of Paclitaxel-Eluting Stents in Patients with Registry Anterior Myocardial Infarction Undergoing Primary Oscar C. Marroquin, Faith Selzer, Suresh R. Mulukutla, Joon S. Lee, Angioplasty Compared with Bare Metal Stents: Conrad Smith, William D. Anderson, Catalin Toma, David O. Williams, Analysis from the HORIZONS AMI trial Sheryl F. Kelsey, Kevin E. Kip, University of Pittsburgh, Pittsburgh, PA Jochen Wöhrle, Bernhard Witzenbichler, Giulio Gualiumi, Bruce R. Learning Objective: Describe the long-term outcomes of off-label Brodie, Dariusz Dudek, Ran Kornowski, Franz Hartmann, Helen use of DES Paris, Alexandra J. Lansky, Carol Moore, Roxana Mehran, Gregg W. Stone, Clinic of Internal Medicine II, University of Ulm, Ulm, 8:24 The PERSEUS Workhorse Randomized Trial of Germany, Cardiovascular Research Foundation and Columbia the Novel Platinum-Chromium Thin-Strut TAXUS University Medical Center, New York, NY Element Paclitaxel-Eluting Stent versus the TAXUS Learning Objective: describe the results of paclitaxel eluting stents Express Stent in de novo Coronary Stenoses for primary PCI in patients with anterior myocardial infarction compared ot bare-metal stents. Louis A. Cannon, Dean J. Kereiakes, Ira M. Dauber, Michael W. Ball, Ameer Kabour, Manu Sondhi, Keith D. Dawkins, Cardiac and Vascular Research Center of Northern Michigan, Northern Michigan 5:18 ST Elevation Myocardial Infarction Due to Left Main Culprit Lesions: Percutaneous Coronary Intervention Regional Hospital, Petoskey, MI, Boston Scientific Corporation, Natick, MA Outcomes Learning Objective: Describe the clinical and angiographic outcomes Gilbert J. Zoghbi, Vijay K. Misra, Brigitta C. Brott, Silvio E. of the PERSEUS WH trial, and evaluate the safety, efficacy, and Papapietro, David Dai, Fang-Shu Ou, Tracy Y. Wang, Lloyd W. technical performance of the TAXUS Element stent relative to the Klein, John C. Messenger, William B. Hillegass, on behalf of the TAXUS Express stent. ACC NCDR Cath PCI Registry Participating Centers, University of Alabama at Birmingham, Brimingham, AL, Duke University Medical Everolimus-Eluting (Xience V) Stents versus Center, Durham, NC 8:36 Sirolimus-Eluting (Cypher) Stents in Patients Learning Objective: Describe well powered multicenter outcomes of with Coronary Artery Disease: Results from a left main STEMI PCI. Randomized Controlled Trial

5:30 Drug-Eluting Stents Are Associated with Decreased Robert A. Byrne, Julinda Mehilli, Klaus Tiroch, Stefanie Schulz, Mortality Among Medicare Beneficiaries Admitted Jürgen Pache, Heidrun Holle, Steffen Massberg, Melchior Seyfarth, with Acute Coronary Syndromes. Katrin A. Birkmeier, Karl-Ludwig Laugwitz, Albert Schömig, Adnan Kastrati, Deutsches Herzzentrum, Technische Universität, Joseph Rossi, Laura P. D’Arcy, Jerome J. Federspeil, Timothy S. Munich, Germany, 1. Medizinische Klinik, Klinikum rechts der Isar, Carey, Sally C. Stearns, Brett C. Sheridan, University of North Technische Universität, Munich, Germany Carolina, Chapel Hill, NC Learning Objective: Evaluate the comparative efficacy of Xience V Learning Objective: Interpret the results of a comparative and Cypher stents effectiveness analysis of DES and BMS using observational data from Medicare beneficiaries. A184 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

8:48 Post-Discharge Bleeding is Associated with Early 10:54 Prevalence and Impact of Renal Failure in Myocardial Infarction and Death after Drug- Octogenarians Undergoing Percutaneous Coronary Eluting Stent Implantation: Insights from the HMO Intervention Research Network- Stent Registry (HMORN-Stent) Jean-Pierre Dery, Helena Tizon-Marcos, Pierre-Louis Bernard, Thomas Tehsin Tsai, P. Michael Ho, Thomas M. Maddox, Nikki M. Julie Plaisance, Cindy Boulanger-Gobeil, Josep Rodés-Cabau, Carroll, Susan M. Shetterly, Stanley Xu, J. David Powers, Karen Gerald Barbeau, Eric Larose, Stephane Rinfret, Can M. Nguyen, Margolis, John S. Rumsfeld, Alan S. Go, David J. Magid, MD, MPH, Onil Gleeton, Guy Proulx, Bernard Noël, Louis Roy, Robert Denver VA Medical Center, Denver, CO, Kaiser Permanente of Delarochellière, Olivier F. Bertrand, Institut universitaire de Colorado, Denver, CO cardiologie et de pneumologie de Quebec, Quebec City, QC, Canada Learning Objective: Identify the risk of early events after post- Learning Objective: determine the prevalence and impact of renal discharge bleeding in patients s/p DES implantation failure in octogenarians undergoing PCi

9:00 Randomized Trial of a Polymer-Free Dual Drug- 11:06 Impact of Diabetes Mellitus on Clinical and Eluting Stent versus Polymer-Based Drug-Eluting Angiographic Outcomes after Treatment of Stents - Two-year Clinical and Angiographic Bifurcation Lesion Using by Single Drug-Eluting Outcomes Stent with Final Kissing Inflation: A Subgroup i2 Summit Analysis of the SINGLE KISS Trial Robert A. Byrne, Adnan Kastrati, Klaus Tiroch, Stefanie Schulz, Jürgen Pache, Susanne Pinieck, Steffen Massberg, Melchior Kenya Nasu, Yuji Oikawa, Tadanori Aizawa, Takahiko Suzuki, Single

(Interventional Cardiology) Seyfarth, Katrin A. Birkmeier, Karl-Ludwig Laugwitz, Albert Schömig, Kiss Trial Investigators, Toyohashi Heart Center, Toyohashi, AL, Julinda Mehilli, Deutsches Herzzentrum, Technische Universität, Japan, The Cardiovascular Hospital, Tokyo, AL, Japan Munich, Germany, 1. Medizinische Klinik, Klinikum rechts der Isar, Learning Objective: understand efficacy of SES and PES for Technische Universität, Munich, Germany bifurcation lesions in patients with diabetes mellitus Learning Objective: To evaluate whether a polymer-free Dual-DES is associated with safety advantages and more durable angiographic 11:18 The Impact of Renal Insufficiency on 2-Year antirestenotic efficacy compared with permanent-polymer DES at Outcomes Following PCI or CABG in the SYNTAX 2 years. Trial

David R. Holmes, Jr., Friedrich W. Mohr, Patrick W. Serruys, Michael 2911 COMPLEX PATIENTS J. Mack, Paul Vermeersch, Philip Van Cauwelaert, Kari Virtanen, Ari Lasse Harjula, Katrin Leadley, Keith D. Dawkins, Mayo Clinic, Tuesday, March 16, 2010, 10:30 a.m. - 12:00 p.m. Rochester, MN, Boston Scientific Corporation, Natick, MA Georgia World Congress Center, Room B315 CME/CE Hours: 1.5 Learning Objective: describe the effect of baseline renal insufficiency on 2-year outcomes in patients with de novo 3VD and/ or LM disease who were revascularized with either CABG or PCI. 10:30 Long-term Clinical Outcome after Implantation of Sirolimus-Eluting and Paclitaxel-Eluting Stents in Infarct Size and Left Ventricular Function in The Patients with and without Diabetes Mellitus - A 11:30 PRoximal Embolic Protection in Acute Myocardial Predefined SORT OUT II Substudy Infarction and Resolution of ST-segment Elevation Michael Maeng, Niels Bligaard, Lisette O. Jensen, Henning Kelbaek, (PREPARE) Trial: Ancillary Cardiovascular Magnetic Jens F. Lassen, Peter R. Hansen, Per Thayssen, Leif Thuesen, Jan Resonance Study S. Jensen, Steen Z. Abildstrøm, Anders M. Galloe, The SORT OUT II Investigators, Aarhus University Hospital, Skejby, Aarhus, Denmark Joost D. Haeck, Wichert J. Kuijt, Karel T. Koch, Luc Bilodeau, José P. Henriques, Wim J. Rohling, Jan Baan, Jr., Marije M. Vis, Robin Learning Objective: evalutate the impact of diabetes on the long- Nijveldt, Nan Van Geloven, Maarten Groenink, Jan J. Piek, Jan G. term outcome after sirolimus-eluting and paclitaxel-eluting stent Tijssen, Mitchell W. Krucoff, Robbert J. De Winter, Academic Medical implantation Center – University of Amsterdam, Amsterdam, The Netherlands

Multivessel Coronary Revascularization in Patients Learning Objective: This study evaluate the effect of combined 10:42 proximal embolic protection and thrombus aspiration on final with and without Diabetes Mellitus 5-Year Follow- infarct size and left ventricular function at 4-6 months after index Up of the ARTS-II trial (Arterial Revascularization procedure. Therapies Study-Part II)

Yoshinobu Onuma, Joanna Wykrzykowska, Pascal Vranckx, Patrick W. Serruys, the ARTS-II Investigators, Thorax Center, Erasmus MC, Rotterdam, The Netherlands Learning Objective: demonstrate a comparative long-term outcome of coronary intervention with Sirolimus-eluting stents with coronary artery bypass in patients who have multivessel disease with and without diabetes JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A185

POSTER CONTRIBUTIONS

2501 DES I AND ACUTE CORONARY SYNDROMES 2501-422 Pre-hospital Reduced-dose Fibrinolytic Therapy Followed by Emergent Percutaneous Intervention Sunday, March 14, 2010, 9:30 a.m. - 10:30 a.m. Reduces Infarct Size and Limits Microvascular Georgia World Congress Center, Hall B5 Obstruction in Patients Treated Within Six Hours of Presentation Hour: 9:30 a.m. - 10:30 a.m. STEMI Onset Without a Bleeding Penalty CME/CE Hours: 1 Troy Weirick, Colin Barker, John LeDoux, Daniel Maland, Eugene Stautberg, Ali Denktas, Stephano Sdringola, Vernon Anderson, 2501-418 Contemporary Clinical Characteristics, Treatment, Catalin Loghin, Jamie McCarthy, David Persse, Mary Vooletich, (Interventional Cardiology) (Interventional and Outcomes of Coronary Stent Thrombosis Richard Smalling, University of Texas at Houston Health Science Center, Houston, TX Khung Keong Yeo, William E. Bennett, Ehtisham Mahmud, Reginald

I. Low, Jason H. Rogers, University of California, Davis Medical Learning Objective: Describe infarct size and microvascular i2 Summit Center, Sacramento, CA, University of California, San Diego Medical obstruction in pre-hospital fibrinolytic treated STEMI patients. Center, San Diego, CA Learning Objective: Describe the clinical and procedural 2501-429 The Incidence And Predictors Of In-hospital Death characteristics, and outcomes of patients who present with stent In Patients With ST-segment Elevation Myocardial thrombosis in the United States Infarct Who Underwent Primary Percutaneous Coronary Intervention Impact of Pre-Operative Clopidogrel Use in Patients 2501-419 Young Jin Youn, Seung Hwan Lee, Sang Woo Han, Jun Won Lee, With Non-ST Segment Elevation Acute Coronary Joong Kyung Sung, Nam Seok Lee, Jang-Young Kim, Junghan Yoon, Syndrome Requiring Coronary Artery Bypass Kyung-Hoon Choe, Wonju Christian Hospital, Wonju, South Korea Grafting: A Meta-Analysis Learning Objective: identify the patient with high risk who undergo Rohit Bhuriya, Pawan Patel, Dhara Chaudhari, Amol Bahekar, Ankur PPCI due to STEMI Sethi, Bassel Artin, Janos Molnar, Sandeep Khosla, The Chicago Medical School, North Chicago, IL 2501-430 In-Hospital Mortality For Paramedic Identified ST Learning Objective: Identify the impact of clopidogrel in the setting Elevation Myocardial Infarction Patients With Pre- of non-ST elevation acute coronary syndrome requiring coronary Hospital Cath Lab Activation Compares Favorably artery bypass grafting. With Emergency Department Activations And With The ACTION Registry 2501-420 Compliance with Dual Antiplatelet Therapy and Subsequent Adverse Events in Patients with STEMI Paul S. Rostykus, Brian W. Gross, Kent W. Dauterman, Stephen J. Schnugg, Todd S. Kotler, Mark G. Moran, Karen A. Bales, Mary E. Undergoing Stent Implantation: Analysis from the Barnum, Rogue Valley Medical Center, Medford, OR, Jackson County HORIZONS-AMI Trial EMS, Medford, OR Roxana Mehran, Eugenia Nikolsky, Bernhard Witzenbichler, Giulio Learning Objective: Describe how pre-hospital paramedic identified Guagliumi, Jan Z. Peruga, Bruce R. Brodie, Dariusz Dudek, Ran STEMI patients have mortality results at least as good those Kornowski, Franz Hartmann, Adriano Caixeta, Nicole Haratani, patients identified in the ED. George D. Dangas, Alexandra J. Lansky, and Gregg W. Stone, Columbia University Medical Center and The Cardiovascular 2501-431 A Novel Strategy To Reduce “ Off-Hours “ Door to Research Foundation, New York, NY Balloon Time in ST Elevation Myocardial Infarction Learning Objective: To defined the rates of and reasons for Syed Tanveer Rab, John S. Douglas, Jr., Leeann Bauch, Jane Wilson, premature cessation of aspirin and/or thienopyridine therapy in pts Samuel Shartar, Matthew Keadey, Leslie Stigaard, M. Rizwan Khalid, with ST-elevation myocardial infarction underwent to PCI Douglas C. Morris, Emory University School of Medicine, Atlanta, GA 2501-421 Impact of Intravenous Heparin Administered Prior Learning Objective: Identify methods to reduce Door to Balloon to Primary Percutaneous Coronary Intervention: time. Analysis from the HORIZONS-AMI Trial 2501-432 Multivessel Versus Culprit-Only Primary Eugenia Nikolsky, Roxana Mehran, George D. Dangas, Alexandra Percutaneous Coronary Intervention in Patients with Lansky, LeRoy Rabbani, Giulio Guagliumi, Ran Kornowski, Franz Multivessel Disease and ST-Elevation Myocardial Hartmann, Martin Fahy, Bernard Witzenbichler, Jan Z. Peruga, Louise Infarction Complicated with Cardiogenic Shock Gambone, Helen Parise, Gregg W. Stone, Cardiovascular Research Foundation, New York, NY Bimmer Claessen, Marije M. Vis, Karel T. Koch, Jan Baan, Jr, Martijn Learning Objective: To assess impact of early administration of Meuwissen, Rob J. de Winter, Jan G. Tijssen, Jan J. Piek, Jose P. heparin in patients with STEMI treated with primary PCI Henriques, Academic Medical Center - University of Amsterdam, Amsterdam, FL, The Netherlands Learning Objective: Evaluate the value of multivessel primary pci in the setting of primary PCI for cardiogenic shock A186 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2501-433 Transradial vs. Transfemoral Approach for Primary 2501-439 Impact of Left Ventricular Function on Mortality Angioplasty in Acute Myocardial Infarction: Analysis in Patients with Acute Coronary Syndromes: from the HORIZONS-AMI Trial. Analysis of the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) Trial Adriano M. Caixeta, Philippe Généreux, Eugenia Nikolsky, Roxana Mehran, Alexandra J. Lansky, Bernhard Witzenbichler, Giulio Alexandra J. Lansky, Vivian Ng, Kenji Goto, Martin Fahy, Roxana Guagliumi, Jan Z. Peruga, Bruce R. Brodie, Dariusz Dudek, Ran Mehran, Ramin Ebrahimian, Marial Hamond, E Magnus Ohman, Kornowski, Franz Hartmann, LeRoy Rabbani, Ecaterina Cristea, Fred Feit, Steven Manoukian, Michael Lincoff, Gregg W. Stone, Shing-Chiu Wong, George D. Dangas, Martin Fahy, and Gregg W. Cardiovascular Research Foundation, New York, NY Stone, Columbia University Medical Center and The Cardiovascular Research Foundation, New York, NY Learning Objective: The impact of LVEF on outcomes in ACS pts

Learning Objective: Toassess outcomes of pts who underwent PCI 2501-443 The Impact of Left Ventricular Function on Mortality for STEMI using radial vs. femoral access in Patients with ST-segment Elevation Acute Myocardial Infarction: Analysis of the Harmonizing 2501-435 Gender differences in Cardiac Pain Perception Outcomes with Revascularization and Stents in during Myocardial Ischemia Acute Myocardial Infarction (HORIZONS-AMI) Study i2 Summit Harald Rittger, Johannes Rieber, Martin Schmidt, Anil-Martin Sinha, Alexandra J. Lansky, Vivian Ng, Bernhard Witzenbichler, Giulio Ole-Alexander Breithardt, Manfred Duecker, Axel Jakob, Johannes Guagliumi, Jan Z. Peruga, Kenji Goto, Helen Parise, Roxana Mehran, Brachmann, Med. Klin. II, Klinikum Coburg, Coburg, Germany, Gregg W. Stone, Cardiovascular Research Foundation, New York, NY Universitätsklinik Muenchen, Campus Innenstadt, Muenchen, (Interventional Cardiology) Germany Learning Objective: To assess the impact of LVEF on outdcomes in STEMI pts undergoing PCI. Learning Objective: To know about different pain cardiac pain perception between men and women 2501-444 Effect of Body Mass Index on Long-Term Mortality After Primary Percutaneous Coronary Intervention ST-Elevation Myocardial Infarction in the Modern 2501-436 in Patients With Acute ST-Segment Elevation Era: Have We Reduced the Gender Disparity? Myocardial Infarction Sara DeReath Collins, Itsik Ben-Dor, Gabriel Maluenda, Manuel Gonzalez, Michael A. Gaglia, Jr, Asmir I. Syed, Kohei Wakabayashi, M. Fuad Jan, Abdul-Moiz Hafiz, Naoyo Mori, Angela Schlemm, Anjan Rebecca Torguson, Zhenyi Xue, Adrian D. Margulies, Nicholas Gupta, Tanvir Bajwa, Anthony C. DeFranco, Suhail Allaqaband, Hanna, Cedric Delhaye, Kenneth M. Kent, Nelson Bernardo, Augusto Aurora Cardiovasc Svcs, Aurora Sinai/St. Luke’s Med Ctrs, Univ D. Pichard, William O. Suddath, Lowell F. Satler, Ron Waksman, Wisconsin Sch Med & Public Health-MCC, Milwaukee, WI, Center Washington Hospital Center, Washington, DC for Urban Population Health, University of Wisconsin-Milwaukee, Milwaukee, WI Learning Objective: Identify causes for gender disparities in outcomes after Primary PCI for treatment of STEMI Learning Objective: demonstrate that body mass index significantly impacts the long-term mortality rate of STEMI patients undergoing primary percutaneous coronary intervention. 2501-437 Impact of Gender on the Extent of Coronary Atherosclerosis and Plaque Characterization in Impact of Smoking and Alternative Antithrombotic Acute Coronary Syndromes: Insights from the 2501-445 Strategies on Outcomes of Patients with ST- PROSPECT Trial Segment Elevation Myocardial Infarction: Alexandra J. Lansky, Akiko Maehara, Gary Mintz, Vivian Ng, Susan Analysis from the Harmonizing Outcomes with Veldhof, Bernard de Bruyne, John McPherson, Ecaterina Cristea, Revascularization and Stents in Acute Myocardial Barry Templin, Helen Parise, Martin Fahy, Patrick W. Serruys, Gregg Infarction (HORIZONS-AMI) Trial W. Stone, Cardiovascular Research Foundation, New York, NY Kenji Goto, Eugenia Nikolsky, Alexandra J. Lansky, Adriano Caixeta, Learning Objective: To characterize sex differences in plaque Martin Fahy, George D. Dangas, Bernhard Witzenbichler, Giulio vulnerability and composition in acute coronary syndromes Guagliumi, Roxana Mehran, Gregg W. Stone, Cardiovascular Research Foundation, New York, NY 2501-438 Myocardial Perfusion Imaging Performance In The Predict Multi-center Trial; Gender Specific Learning Objective: demonstrate impact of smoking on outcomes of patients with STEMI treated with primary PCI using alternative Analysis And Comparison With The Corus Cad Gene antithrombotic strategies. Expression Score

Alexandra J. Lansky, Michael R. Elashoff, Amy J. Sehnert, Hsiao 2501-446 Characteristics And Long-term Outcomes Of D. Lieu, James A. Wingrove, Susan E. Daniels, Steven Rosenberg, Elderly Patients With Acute Myocardial Infarction Szilard Voros, Robert S. Schwartz, William E. Kraus, Eric J. Topol, Complicated By Cardiogenic Shock Undergoing Cardiovascular Research Foundation, New York, NY Percutaneous Coronary Interventions.

Learning Objective: To understand that positive myocardial perfusion Francesco Tomassini, Andrea Gagnor, Emanuele Tizzani, Maria imaging results were not predictive of obstructive CAD in women Cristina Marocco, Vincenzo Infantino, Maria Rosa Conte, Ferdinando and that the Corus CAD gene expression score added diagnostic Varbella, Rivoli, Italy value on a gender basis Learning Objective: to demonstrate the importance of revascularization in acute myocardial infarction complicated by cardiogenic shock JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A187

2501-447 Age and One-Year Mortality After ST Elevation 2501-453 Sustained Ventricular Arrhythmias add Prognostic Myocardial Infarction Treated With Primary value Independent of Underlying Risk in STEMI Percutaneous Intervention Patients Undergoing Primary Percutaneous Coronary Intervention Bimmer Claessen, Wouter J. Kikkert, Karel T. Koch, Marije M. Vis, Jan Baan, Jr., Martijn Meuwissen, Robbert J. de Winter, Jan GP Rajendra H. Mehta, Aijing Z. Starr, Renato D. Lopes, Jonathan P. Tijssen, Jan J. Piek, José PS Henriques, Academic Medical Center, Piccini, Paul W. Armstrong, Christopher B. Granger, Duke Clinical Amsterdam, The Netherlands Research Institute and Duke University Medical Center, Durham, NC, University of Alberta, Alberta, Canada Learning Objective: Identify the importance of older age as a predictor for one-year mortality after primary PCI Learning Objective: To Demonstrate that the Association of

Ventricular Arrhythmias with Outcomes in Patients Undergoing Cardiology) (Interventional 2501-449 Patients Admitted with ST-segment Elevation Primary PCI is Independent of Their Underlying Risk Myocardial Infarction and a Normal or Near Normal

Coronary Angiogram Have a Favorable Prognosis: 2501-455 Increased Levels Of Circulating Endothelial i2 Summit Analysis from Horizons-AMI trial Progenitor Cells In Intracoronary Blood Of ST- Elevation Myocardial Infarction Patients Correlate Alf-Ing Larsen, Dennis WT Nilsen, Eugenia Nikolsky, Alexandra With Microvascular Damage. J. Lansky, Adriano Caixeta, Helen Parise, Martin Fahy, Ecaterina Criatea, Bernhard Witzenbichler, Giulio Guagliumi, Jan Z. Peruga, Italo Porto, Luigi M Biasucci, Giovanni Luigi De Maria, Luca Di Vito, Bruce R. Brodie, Dariusz Dudek, Roxana Mehran, Gregg W. Stone, Antonio M Leone, Giampaolo Niccoli, Alessandra Tritarelli, Giuliana Stavanger University Hospital and The University of Bergen, Bergen, Di Rocco, Maurizio Capogrossi, Filippo Crea, Catholic University of Norway the Sacred Heart, Rome, Italy Learning Objective: To assess outcomes of patients with non- Learning Objective: demonstrate the immediate recruitment obstructive CAD admitted for STEMI of of endothelial progenitor cells in the culprit coronary artery, proportional to the amount of damaged microvasculature 2501-450 Diagnostic Uncertainty of 12-lead ECG for Diagnosing Posterior Wall Myocardial Infarction 2501-456 Mobilization of Endothelial Progenitor Cells and Neointima Formation after Implantation of EPC- SungSoo Kim, Myung Ho Jeong, Young Keun Ahn, Jeong Gwan Cho, Capture Stents in NSTE-ACS (JACK-EPC randomized Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Seung Ho Hur, In Whan Seong, Taek Jong Hong, Dong Hoon Choi, Myeong Chan trial) Cho, Chong Jin Kim, Ki Bae Seung, Wook Sung Chung, Yang Soo Wojciech Wojakowski, Andrzej Pyrlik, Marek Krol, Maciej Kazmierski, Jang, Seung Woon Rha, Jang Ho Bae, Seung Jung Park, Chonnam Andrzej Ochala, Pawel Buszman, Damian Kawecki, Andrzej Rudnik, National University Hospital, Gwang Ju, South Korea Grzegorz Smolka, Krzysztof Milewski, Aleksander Zurakowski, Learning Objective: 12 lead ECG was not suitable for evaluate Wieslaw Cybulski, Marek Kondys, Iwona Mroz, Michal Tendera, posterior wall myocardial infarction associated with left circumflex Medical University of Silesia, Katowice, Poland, American Heart of artery territory Poland, Ustron, Poland Learning Objective: identify the mobilization of endothelial 2501-451 Mitral Regurgitation Predicts Long-Term Mortality progenitor cells as one of the factors that influence the neointima Risk After Primary Percutaneous Coronary formation Intervention for Acute ST-Elevation Myocardial Infarction 2501-457 Predictors Of Lipoprotein-associated Phospholipase A2 Mass And Activity Levels Among Patients With Ahmed M. Uddin, Timothy D. Henry, James S. Hodges, Wesley R. Stable And Acute Coronary Syndromes: A CREDO Pedersen, Kevin M. Harris, Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN Biomarker Substudy Learning Objective: Understand importance of mitral regurgitation in Herbert D. Aronow, W. H. Wilson Tang, Steven Steinhubl, Danielle acute myocardial infarction 2501-452 Brennan, Robert Wilensky, Steven Marso, Peter Berger, Michael Impact of Peri-procedural Atrial Fibrillation on Short-term Clinical Wegner, Eric Topol, Michigan Heart & Vascular Institute, Ann Outcomes Following Percutaneous Coronary Intervention Arbor, MI Learning Objective: Describe predictors of Lp-PLA2 mass and 2501-452 Impact of Peri-procedural Atrial Fibrillation activity levels among patients undergoing PCI. on Short-term Clinical Outcomes Following Percutaneous Coronary Intervention” above author 2501-458 The Effect Of Platelet Reactivity On Infarct Related block Artery Patency In Patients With ST-elevation Myocardial Infarction William Chan, Andrew E. Ajani, David J. Clark, Nick Andrianopoulos, Angela L. Brennan, Christopher M. Reid, Gishel New, Peter M. Nicoline J. Breet, Carina ACM Pittens, Heleen J. Bouman, Jochem W. Kistler, Anthony M. Dart, Stephen J. Duffy, The Alfred Hospital, van Werkum, Jurrien M. ten Berg, Christian M. Hackeng, St.Antonius Melbourne, Australia Ziekenhuis, Nieuwegein, The Netherlands, St.Antonius Center for Learning Objective: evaluate the impact of peri-procedural atrial Platelet Function Research, Nieuwegein, The Netherlands fibrillation on short-term clinical outcomes following percutaneous Learning Objective: desrcibe the relationship between infarct-related coronary intervention artery patency and platelet reactivity A188 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2501-459 Platelet-Derived Microparticles And C-Reactive 2501-464 Procedural Myocardial Protection by Short-term Protein In Intracoronary And Peripheral Blood Of Atorvastatin Load is Related to Lower Levels of ST-Elevation Myocardial Infarction Patients. Adhesion Molecules After Percutaneous Coronary Intervention in Patients With Acute Coronary Italo Porto, Luigi M Biasucci, Giovanni Luigi De Maria, Luca Di Vito, Syndromes. Results From the ARMYDA-ACS CAMs Francesco Burzotta, Antonio M Leone, Alessandra Tritarelli, Giuliana Di Rocco, Maurizio Capogrossi, Filippo Crea, Catholic University of (Atorvastatin for Reduction of MYocardial Damage the Sacred Heart, Rome, Italy During Angioplasty-Cell Adhesion Molecules) Substudy Learning Objective: evaluate the role of microparticles in the intracoronary thrombus formation Laura Gatto, Giuseppe Patti, Massimo Chello, Elisabetta Ricottini, Diego Colonna, Elvio Covino, Marco Miglionico, Fabio Mangiacapra, 2501-460 The Use Of Bare-Metals Stents In Primary Annunziata Nusca, Germano Di Sciascio, Campus Bio-Medico Percutaneous Coronary Intervention For Acute University, Rome, Italy, Second University of Naples, Naples, Italy Myocardial Infarction: Is There A Difference In Learning Objective: to demonstrate that short-term atorvastatin Clinical Outcome Between Cobalt Chromium Versus load is associated with attenuation of endothelial inflammatory Stainless Steel Stents? response in patients with ACS undergoing PCI i2 Summit Angela Koh, Lok Man Choi, Lay Wai Khin, Ling Ling Sim, Terrance Five-year Prognostic Value of No-reflow SJ Chua, Tian Hai Koh, Jack WC Tan, Stanley Chia, National Heart 2501-489 Phenomenon After Percutaneous Coronary Centre, Singapore, Singapore Intervention in Patients with Acute Myocardial (Interventional Cardiology) Learning Objective: Evaluate differences in clinical outcome Infarction between cobalt chromium versus stainless steel bare metal stents after PCI for Acute STEMI Katrin A. Birkmeier, Gjin Ndrepepa, Klaus Tiroch, Julinda Mehilli, Melanie Nordmann, Patricia Alger, Isabell Bernlochner, Rene 2501-461 Everolimus-eluting Stent Shows Equivalency To Vollenbroich, Julia Goedel, Julia Ellert, Adnan Kastrati, Albert First And Second Generation Drug-eluting Stents Schömig, Deutsches Herzzentrum, Technische Universität, In Terms Of Major Cardiac Adverse Events At Munich, Germany, 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität, Munich, Germany Short-term Follow-up After Primary Percutaneous Coronary Intervention In St-elevation Myocardial Learning Objective: interpret the impact of no-reflow phenomenon Infarction on five-year mortality in patients with STEMI

kyounghoon Lee, Tae Hoon Ahn, Woong Chol Kang, Seung Hwan 2501-490 Distal Protection Can Preserve Index of Han, In Suck Choi, Eak Kyun Shin, Gil Hospital, Gachon University, Microcirculatory Resistance in Patients With Incheon, South Korea, Gil Hospital, Gachon University, Incheon, ST-Segment Elevation Anterior Wall Myocardial South Korea Infarction Learning Objective: evaluate Noritoshi Ito, Shinsuke Nanto, Yasuji Doi, Hirotaka Sawano, Daisaku Everolimus-Eluting Stents Suppress In Vivo Plaque Masuda, Shizuya Yamashita, Mai Hatano, Daisuke Tonomura, Yuma 2501-462 Kurozumi, Tomoaki Natsukawa, Yusuke Ito, Kazuyuki Oka, Jiro Ooba, Inflammatory Protease Activity As Detected By Taizo Hasegawa, Makoto Kobayashi, Hiroshi Ichiyanagi, Koji Akashi, Intravascular Fluorescence Molecular Imaging Koichi Otsuya, Shoji Kaibe, Ken-ichiro Okada, Yasuyuki Hayashi, Marcella A. Calfon, Georgios Mallas, Amir Rosenthal, Alexander Tatsuro Kai, Toru Hayashi, Osaka Saiseikai Senri Hospital, Suita, J. Sheehy, Igor Polyakov, R. Nika Razansky, Luis Guerrero, Adam Japan, Osaka University Graduate School of Medicine, Suita, Japan Mauskapf, Frank Kolodgie, Renu Virmani, Ntziachristos Vasilis, Learning Objective: identify that distal protection can preserve index Farouc Jaffer, Massachusetts General Hospital, Boston, MA of microcirculatory resistance (IMR) after primary PCI in patients Learning Objective: To evaluate, using a novel in vivo intravascular with anterior STEMI. catheter and NIRF molecular imaging, the anti-inflammatory effects of everolimus-eluting versus bare metal stents in rabbit atheromata. 2501-491 Impact Of Thrombectomy With Export Catheter In Infarct Related Artery During Primary Pci On 2501-463 Microvascular Dysfunction Assessed by Coronary Procedural Outcome In Patients With Ami (EXPIRA Flow Velocity Pattern as a Predictor of Left Trial).The Importance Of Thrombectomy On Des Ventricular Remodeling and Thrombus Formation in Implantation Clinical Outcome Substudy. Patients with Anterior Acute Myocardial Infarction Gennaro Sardella, Massimo Mancone, Emanuele Canali, Luigi Yoshimori An, Atsushi Yamamuro, Shuichiro Kaji, Makoto Kinoshita, Lucisano, Rocco Stio, Giulia Benedetti, Angelo Di Roma, Luciano Natsuhiko Ehara, Atsushi Kobori, Takeshi Kitai, Kitae Kim, Tomoko Agati, Francesco Fedele, Dept.Cardiovascular Sciences,Policlinico Tani, Toru Kita, Yutaka Furukawa, Kobe City Medical Center General Umberto I, Rome, MD, Italy Hospital, Kobe, CA, Japan Learning Objective: To show the manual thrombectomy impact on Learning Objective: demonstrate the efficacy of coronary flow primary PCI procedural and long term outcome in particular after velocity DES implantation. JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A189

2501-492 Percutaneous Intervention of Acutely Occluded 2501-497 Spatial Coronary Arterial Distribution of Non-Culprit Saphenous Vein Grafts: Contemporary Techniques Lesion Atherosclerotic Events: Analysis from the and Outcomes PROSPECT Trial.

Abdul_rahman R. Abdel-karim, Subhash Banerjee, Emmanouil S. Adriano M. Caixeta, Alexandra J. Lansky, Ecaterina Cristea, Bernard Brilakis, Veteran Affairs North Texas Healthcare System, Dallas, TX, de Bruyne, John McPherson, Akiko Maehara, Gary S. Mintz, Roxana University of Texas Southwestern Medical Center, Dallas, TX Mehran, Eugenia Nikolsky, Barry Templin, Patrick W. Serruys, and Gregg W. Stone, Columbia University Medical Center and the Learning Objective: Describe outcomes in patients with acutely Cardiovascular Research Foundation, New York, NY occluded saphenous vein grafts undergoing percutanuous interventions Learning Objective: To assess the incidence and angiographic

location of major adverse cardiovascular events in a natural history Cardiology) (Interventional 2501-493 Clinical Benefits of Thrombus Aspiration During study of atherosclerosis Primary Percutaneous Coronary Intervention for

Acute Myocardial Infarction 2501-498 In Vivo Assessment of Vulnerable Plaque by i2 Summit Multislice Computed Tomography Comparison With Ju Han Kim, Doo Sun Sim, Myeong Chan Cho, Hyo Soo Kim, Optical Coherence Tomography Dong Ju Choi, Tae Jin Youn, Myung Ho Jeong, Chonnam National University Hospital, Gwangju, South Korea Ito Tsuyoshi, Mitsuyasu Terashima, Mariko Ehara, Hitoshi Matsuo, Masashi Kimura, Kenya Nasu, Nobuyoshi Tanaka, Maoto Habara, Learning Objective: appreciate the need to revisit the effect of Etsuo Tsuchikane, Yoshihisa Kinoshita, Yasushi Asakura, Osamu thrombus aspiration in patients with acute myocardial infarction Kato, Takahiko Suzuki, Toyohashi Heart Center, Toyohashi, AL, Japan undergoing primary percutaneous coronary intervention Learning Objective: interpret 2501-494 Association of Admission Hyperglycemia with Impaired Coronary Flow Velocity Pattern and Left 2501-500 Coronary Plaque Characteristics According to the Ventricular Remodeling in Patients with Acute Renal Function in Patients with Acute Myocardial Anterior Myocardial Infarction Infarction: An Intravascular Ultrasound Analysis

Yoshimori An, Atsushi Yamamuro, Shuichiro Kaji, Makoto Kinoshita, Young Joon Hong, Gary S. Mintz, Myung Ho Jeong, Jum Suk Ko, Natsuhiko Ehara, Atsushi Kobori, Takeshi Kitai, Kitae Kim, Tomoko Min Goo Lee, Keun Ho Park, Doo Sun Sim, Ju Han Kim, Youngkeun Tani, Toru Kita, Yutaka Furukawa, Kobe City Medical Center General Ahn, Jeong Gwan Cho, Jong Chun Park, Neil J. Weissman, Jung Hospital, Kobe, CA, Japan Chaee Kang, Heart Center of Chonnam National University Hospital, Gwangju, South Korea, Cardiovascular Research Institute/Medstar Learning Objective: To demonstrate the association between Research Institute, Washington Hospital Center, Washington, DC admission hyperglycemia and microvascular dysfunction Learning Objective: to assess plaque characteristics in acute 2501-495 Which Virtual Histology Intravascular Ultrasound myocardial infarction patients with varying degrees of renal Properties Discriminate Better Between Stable dysfunction. Angina Pectoris and Troponin Positive Acute Coronary Syndrome - Assessment of Plaques or 2501-501 In Vivo Morphologic Analysis of Plaque Rupture in Analysis of the Whole Coronary Artery Vasculature? Culprit Lesions of Patients With Acute Coronary Syndromes. An Optical Coherence Tomography Patrick A. Calvert, Daniel Obaid, Nick E. West, Leonard M. Shapiro, Study Duncan McNab, Cameron G. Densem, Peter M. Schofield, Denise Braganza, Sarah C. Clarke, Michael O’Sullivan, Kausik K. Ray, Antonios Karanasos, Konstantinos Toutouzas, Andreas Synetos, Martin R. Bennett, Division of Cardiovascular Medicine, University of Elefterios Tsiamis, Maria Drakopoulou, John Karambelas, Costas Cambridge, Cambridge, United Kingdom, Papworth NHS Foundation Tsioufis, Dimitrios Tousoulis, Elli Stefanadi, Christodoulos Trust Hospital, Cambridge, United Kingdom Stefanadis, 1st Department of Cardiology, Hippokration Hospital, Athens, Greece Learning Objective: Describe the virtual histology intravascular ultrasound appears of coronary artery plaques that distinguish Learning Objective: distinguish the in vivo morphology of ruptured stable from vulnerable plaques which result in myocardial infarction plaque

2501-496 Virtual Histology Intravascular Ultrasound 2501-502 Thinner Fibrous Cap and Greater Incidence of Demonstrates Not Only Vessel Size But Also Plaque Rupture Characterize Culprit Lesions Dense Calcium Component Is Associated With in Proximal Segments of Coronary Arteries as Underexpansion Of Drug Eluting Stents In Patients Assessed by Optical Coherence Tomography With Acute Myocardial Infarction Maria Riga, Konstantinos Toutouzas, Maria Drakopoulou, John Wang-Soo Lee, Sang-Wook Kim, Hak-Jin Kim, Jung-Eun Kim, Eun- Karampelas, Antonis Karanasos, Eleftherios Tsiamis, Dimitrios Jeong Cho, Kwang-Je Lee, Tae-Ho Kim, Chee-Jeong Kim, Wang-Seong Tousoulis, Elli Stefanadi, Christodoulos Stefanadis, Hippokration Ryu, Chung-Ang University Hospital, Seoul, South Korea Hospital, Athens, Greece Learning Objective: This demonstrates an impact of plaque Learning Objective: Interpret the higher frequency of acute coronary composition on underexpansion, possible cause of stent syndromes in the proximal segments of coronary arteries thrombosis, coronary stenting in patients with acute myocardial infarction treated with drug eluting stent. A190 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2501-503 In Vivo Comparison of Morphological Characteristics 2501-509 Safety And Efficacy Of Drug Eluting Stents And of Culprit Lesions Between Patients With ST Bare Metal Stents For Saphenous Vein Graft Elevation Myocardial Infarction and Non ST Interventions- Comprehensive Meta-analysis Of Elevation Acute Coronary Syndrome. An Optical Randomized Trials And Observational Studies Coherence Tomography Study. Comprising 7994 Patients

Maria Riga, Konstantinos Toutouzas, Antonis Karanasos, Maria Abdul Hakeem, Siddharth Munsif, Sabha Bhatti, Mohamed Effat, Drakopoulou, John Karampelas, Eleftherios Tsiamis, Archontoula Massoud Leesar, Tarek Helmy, Imran Arif, University of Cincinnati, Michelongona, Costas Tsioufis, Christodoulos Stefanadis, College of Medicine, Cincinnati, OH Hippokration Hospital, Athens, Greece Learning Objective: understand the safety and efficacy of drug Learning Objective: Understand a part of the pathophysiological sluting stent for saphenous vein graft lesions mechanisms responsible for the clinical onset of acute coronary syndromes, which are related to the morphological characteristics 2501-510 Risk Factor for Coronary Artery Aneurysm of vulnerable plaques. Formation as a Complication of Drug-Eluting Stent Implantation: The results of 3 year serial 2501-504 Incomplete Three-vessel Intravascular Imaging in angiographic follow-up the PROSPECT Trial: Implications for Pre-emptive i2 Summit Vulnerable Plaque Detection Ung Kim, Dong-Kie Kim, Sang-Hoon Seol, Tae-Hyun Yang, Dae- Kyeong Kim, Doo-Il Kim, Dong-Soo Kim, Inje University Busan Paik Akiko Maehara, Gary S. Mintz, Alexandra J. Lansky, Ecaterina Hospital, Busan, South Korea

(Interventional Cardiology) Cristea, Roxana Mehran, George Dangas, Barry Templin, John McPherson, Bernard de Bruyne, Naim Farhat, Bertil Wennerblom, Learning Objective: This study identify risk factors for coronary Andrés Iñiguez, Steven Marso, Patrick W. Serruys, Gregg W. Stone, artery aneurysm as a complication of drug-eluting stent Cardiovascular Research Foundation and Columbia University Medical Center, New York City, NY 2501-511 What Is The Optimal Rate Of Drug-eluting Stent Use? Insights From Temporal Analysis Of The Learning Objective: To understand the limitations of intravascular Multicenter Event Registry imaging in VP detection Lakshmi VENKITACHALAM, Yang Lei, Joshua M. Stolker, Amit P. Amin, 2501-506 Safety And Efficacy of Early Versus Delayed Jason B. Lindsey, Kevin F. Kennedy, Michael Pencina, John J. Lopez, Intervention in Acute Coronary Syndromes Neil S. Kleiman, David J. Cohen, Saint Luke’s Mid America Heart Without ST-Segment Elevation: A Meta-Analysis of Institute, Kansas City, MO Randomized Trials Learning Objective: Understand the temporal trend in prevalence of DES use and its impact on clinical outcomes at one year after PCI Param P. Singh, Rohit Bhuriya, Updesh S. Bedi, Janos Molnar, Rohit Arora, Chicago Medical School/RFUMS, North Chicago, IL 2501-512 Cost-Effectiveness of “Off-Label” Drug Eluting Stent Learning Objective: Demonstrate safety and efficacy of early versus Bare Metal Stent Use percutaneous coronary intervention in patients with acute coronary syndromes without ST-segment elevation Pascha Schafer, Matthew Sacrinty, Michael A. Kutcher, Renato Santos, Sanjay K. Gandhi, William C. Little, Robert J. Applegate, 2501-507 Outcomes Of Patients With Acute Coronary Wake Forest University School of Medicine, Winston-Salem, NC Syndromes And Prior Coronary Artery Bypass Learning Objective: To understand cost effectiveness analysis with Grafting: Analysis From The Acuity Trial the use of drug eluting stent and bare metal stent. Eugenia Nikolsky, Roxana Mehran, E. Magnus Ohman, Michel E. Angiographic Features Related to Incomplete Stent Bertrand, A. Michael Lincoff, Jeffrey W. Moses, Ecaterina Cristea, 2501-514 Harvey D. White, Martin Fahy, Alexandra J. Lansky, Gregg W. Stone, Apposition in SPIRIT III Trial. A Quantitative Analysis Cardiovascular Research Foundation, New York, NY of Vessel Curvature Learning Objective: To assess outcomes of patients with ACS and Moyses Oliveira Lima-Filho, Alexandra J. Lansky, Masao Yamasaki, prior CABG and impact of different antithrombotic therapies on Junya Ako, Andreas Wahle, Ping Yu, Takao Shimohama, Katsuhisa prognosis in this high-risk population Waseda, Bon-Kwon Koo, Daysaku Nakatami, Hiromasa Otake, Yasuhiro Honda, Krishnankutty Sudhir, Gregg W. Stone, Peter 2501-508 Pathology of Drug-Eluting Stents in Saphenous Vein J. Fitzgerald, Center for Cardiovascular Technology - Stanford Graft Lesions University, Stanford, CA, Columbia University Medical Center, New York, NY Saami K. Yazdani, Fank D. Kolodgie, Renu Virmani, CVPath Institute, Learning Objective: Evaluate the importance of coronary anatomy Gaithersburg, MD on the ocurrence of incomplete stent apposition Learning Objective: Demonstrate the pathologic response of saphenous vein grafts to drug eluting stents and bare metal stents. JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A191

2501-515 Angiographic Patterns of Late Restenosis after 2501-521 Drug-Eluting Stent Use Continues to Decline, Sirolimus-Eluting Stent Implantation: Serial Especially in Acute Myocardial Infarction, Despite (8-month and 2-year) Angiographic Follow-up Resolution of the Controversy over Late Thrombosis

Nehiro Kuriyama, Yoshio Kobayashi, Tatsuya Nakama, Daigo Leo Marcoff, Claudine T. Jurkovitz, Daniel Murphy, Paul Kolm, James Mine, Mitsuhiro Shimomura, Kensaku Nishihira, Katsumasa R. Bowen, William S. Weintraub, Ehsanur Rahman, Christiana Care Nomura, Keiichi Ashikaga, Akihiko Matsuyama, Yoshisato Shibata, Health System, Newark, DE Department of Cardiology, Miyazaki Medical Association Hospital, Learning Objective: Describe temporal trends in the use of drug- Miyazaki, Japan, Department of Cardiovascular Science and eluting stents Medicine, Chiba University Graduate School of Medicine, Chiba, Japan 2501-522 Incidence and Predictors of Stent Thrombosis Up Cardiology) (Interventional Learning Objective: describe angiographic pattern of late restenosis to 7 Years Follow-up Following Drug-Eluting Stent after sirolimus-eluting stent implantation. Implantation in Unselected Patients with Complex Coronary Lesions Treated in the Real-World Clinical i2 Summit 2501-516 Higher Baseline Inflammatory Burden is Associated Practice - A Subanalysis from the Drug-Eluting Stent with Worse Prognosis in Patients with Stable In the REal World “DESIRE” Registry Coronary Artery Disease Undergoing Coronary Stenting Ricardo A. Costa, Amanda Sousa, Adriana Moreira, J. Ribamar Costa, Jr, Galo Maldonado, Manuel Cano, Fausto Feres, Luiz A. Nima Ghasemzadeh, Zohreh Forghani, Konstantinos Aznaouridis, Mattos, Rodolfo Staico, Alexandre Abizaid, Cantídio Campos, Paddi K. Reddy, Christine DeStareck, Craig Hooper, Arshed A. Mariana T. Carballo, Otávio Berwanger, J. Eduardo Sousa, Hospital Quyyumi, Kreton Mavromatis, Emory University, Atlanta, GA, Atlanta do Coração - Associação do Sanatório Sírio, Sao Paulo, NY, Brazil VA Medical Center, Decatur, GA Learning Objective: Demonstrate the late incidence and Learning Objective: Demonstrates predictors of prognosis in independent predictors of stent thrombosis following drug-eluting patients with stable coronary artery disease undergoing coronary stent implantation in the real-world clinical practice stenting 2501-523 Evaluation of Thienopyridine Compliance and Stent 2501-517 Long-term Survival Following Multivessel Versus Thrombosis Rates after Everolimus-Eluting and Single-Vessel Percutaneous Coronary Interventions Paclitaxel-Eluting Stent Implantation: 3-Year Results in the Contemporary Drug-Eluting Stent Era from the SPIRIT III Analysis

Joseph M. Lee, S. Chiu Wong, Robert M. Minutello, Geoffrey David Alan Cox, Krishnankutty Sudhir, James B. Hermiller, Robert Bergman, Issam Moussa, Dmitriy N. Feldman, New York J. Applegate, Paul C. Gordon, Julie Doostzadeh, Lalitha K. Presbyterian Hospital - Weill Cornell Medical College, New York, NY Jonnavithula, Kai Koo, Thomas H. Maloney, Alexandra J. Lansky, Learning Objective: evaluate long-term outcomes in patients Charles A. Simonton, Gregg W. Stone, Lehigh Valley Hospital, undergoing multivessel versus single-vessel PCI Allentown, PA Learning Objective: Evaluate differences in DES stent thrombosis 2501-518 Value Of The Syntax Score (SX) For Risk rates in the SPIRIT-III Trial Assessment In The “All-comers” Population Of The Randomized Multicenter Leaders Trial. 2501-524 Impact of Bleeding on the Long-term Outcomes after Drug -Eluting Stent Implantation in the Real- Joanna J. Wykrzykowska, Scot Garg, Chrystafios Girasis, Ton de Vries, Marie-angele Morel, Marie-angele Morel, Gerrit-Anne World Practice van Es, Pawel Buszman, Axel Linke, Thomas Ischinger, Volker Young-Hak Kim, Jong-Young Lee, Won-Jang Kim, Sung-Cheol Yun, Klauss, Roberto Corti, Franz Eberli, William Wijns, Marie-Claude Jung-Min Ahn, Junhyok Oh, Haegeun Song, Duk-Woo Park, Soo-Jin Morice, Carlo di Mario, Robert Jan van Geuns, Peter Juni, Stephan Kang, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung- Windecker, Patrick W. Serruys, Thoraxcenter, Erasmus MC, Jung Park, Asan Medical Center, Seoul, South Korea Rotterdam, The Netherlands Learning Objective: identify clinical impact of bleeding Learning Objective: Appreciate the need for new risk assessment tools in patients undergoing PCI. 2501-531 Six Years Optical Coherence Tomography, Intravascular Ultrasound, and Quantitative Coronary Differences in Coronary Intravascular Ultrasound 2501-520 Angiography Follow-up of Patients with Coronary Findings in Early, Late, and Very Late Stent Lesions Treated with the Biolimus A9-Eluting Stents Thrombosis After Sirolimus-eluting Stent with a Bioabsorbable Polymer Implantation. Ricardo A. Costa, Alexandre Abizaid, J. Ribamar Costa, Rodolfo Masashi Kimura, Soichiro Ebisawa, Nobuyoshi Tanaka, Kenya Nasu, Staico, Fausto Feres, Marinella Centermero, Vinicius Esteves, Mariko Ehara, Tatsuya Ito, Yoshihisa Kinoshita, Etsuo Tsuchikae, Dimytri Siqueira, Daniel Chamié, Luiz A. Mattos, Amanda Sousa, Mitsuyasu Terashima, Yasushi Asaskura, Osamu Katoh, Takahiko J. Eduardo Sousa, Eberhard Grube, Instituto Dante Pazzanese de Suzuki, Toyohashi Heart Center, Toyohashi, NY, Japan Cardiologia, Sao Paulo, NY, Brazil Learning Objective: evaluate acute and long-term intravascular Learning Objective: Demonstrate the the very late (6 years) stent ultrasound (IVUS) findings in pts with ST. coverage pattern by OCT and angiograhpic and IVUS results in the biolimus A9-coated stent with a biodegradable polymer compared to bare metal stents A192 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2501-532 Are Second-Generation Drug-Eluting Stents 2502 DES II, RESTENOSIS, LEFT MAIN AND OUTCOMES Associated with Reduction of Periprocedural Myocardial Infarction Post-Percutaneous Coronary Sunday, March 14, 2010, 3:30 p.m. - 4:30 p.m. Intervention? Georgia World Congress Center, Hall B5 Presentation Hour: 3:30 p.m. - 4:30 p.m. Kohei Wakabayashi, Loic Belle, Itsik Ben-Dor, Cedric Delhaye, Sara D. Collins, Nicholas N. Hanna, Manuel A. Gonzalez, Gabriel Maluenda, CME/CE Hours: 1 Rebecca Torguson, Zhenyi Xue, William O. Suddath, Lowell F. Satler, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard, Ron Waksman, 2502-418 Comparison Of Vascular Inflammation And Washington Hospital Center, Washington, DC Endothelial Function In Response To A New Nobori And Cypher Drug Eluting Stents In Pig Coronary Learning Objective: Xience V stent protected CPK-MB increase post Arteries PCI compared with the other DES. Xience V stent might reduce MI after PCI because of superior stent design. Jin-Shen Li, Lakshmana K. Pendyala, Daisuke Matsumoto, Sarah Geva, Toshiro Shinke, Dongming Hou, Jack P. Chen, Jaipal Singh, 2501-533 Performance of XIENCE V Everolimus-Eluting vs. Nicolas Chronos, Saint Joseph’s Translational Research Institute/ TAXUS Express Paclitaxel-Eluting Coronary Stents in Saint Joseph’s Hospital of Atlanta, Atlanta, GA Small Vessels: Pooled Results of the SPIRIT III and Learning Objective: evaluate endothelial function in DESs i2 Summit SPIRIT IV Clinical Trials

James Bernard Hermiller, Jr., Robert Applegate, Julie Dootzadeh, 2502-419 Is There A Difference In Vascular Response Between Biodegradable Polymer-based Versus Nonpolymer- (Interventional Cardiology) Wesley Pierson, Aakar Shah, John Peterson, Krishnankutty Sudhir, Gregg Stone, St Vincent Heart Center of Indiana, Indianapolis, IN based Biolimus-eluting Stent? Short-term Intravascular Ultrasound Results From STEALTH And Learning Objective: Identify the relative merits of EES vs PES Drug- Eluting Stents in small vessel coronary artery disease BioFreedom Trial Byoung-Keuk Kim, Hiromasa Otake, Katsuhisa Waseda, Daisaku 2501-534 Five-Year Clinical Outcomes of Sirolimus-Eluting Nakatani, Kenji Sakata, Yoshihisa Shimada, Tomomi Koizumi, Versus Paclitaxel-Eluting Stents in High Risk Patient Yasuhiro Honda, Eberhard Grube, Peter J. Fitzgerald, Stanford Subsets: A Pooled Analysis of 3 Randomized Trials university, Stanford, CA, Helios Heart Center, Siegburg, Germany

Katrin A. Birkmeier, Adnan Kastrati, Robert A. Byrne, Klaus Tiroch, Learning Objective: The aim of this study was to evaluate potential Heidrun Holle, Stefanie Schulz, Sebastian Kufner, Steffen Massberg, impact of the different carrier systems such as nonpolymer or Karl-Ludwig Laugwitz, Albert Schömig, Julinda Mehilli, Deutsches biodegradable polymer on vascular response to the Biolimus A9- Herzzentrum, Technische Universität, Munich, Germany, 1. eluting stents. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität, Munich, Germany 2502-420 A Randomized Comparison Of Nobori Biolimus A9 Eluting Stent With Cypher Sirolimus Eluting Learning Objective: evaluate the long-term efficacy and safety of sirolimus- and paclitaxel-eluting stents Stent For Coronary Revascularization In Japanese Population

2501-535 Comparison of Clinical Outcomes Between Toshiya Muramatsu, Masashi Iwabuchi, Shigeru Saito, Yasuhiko Zotarolimus- and Sirolimus- Eluting Stents Hayashi, Yuji Ikari, Kenshi Fujii, Shinsuke Nanto, Naoto Inoue, in Patients with ST-segment Elevation Acute Takeshi Kimura, Atsuo Namiki, Haruo Hirayama, Osamu Doi, Mitsuo Myocardial Infarction Kashida, Junji Yajima, Kazuaki Mitsudo, Saiseikai Yokohama-city Eastern Hospital, Yokohama, Japan Hyun Kuk Kim, Myung Ho Jeong, Youngkeun Ahn, Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Seung Ho Hur, In Whan Seong, Learning Objective: This is the world first RCT report of Nobori Taek Jong Hong, Dong Hoon Choi, Myeong Chan Cho, Chong Jin Biolimus Eluting stent compared to SES (Cypher) to know the level Kim, Ki Bae Seung, Yang Soo Jang, Seung Woon Rha, Jang Ho Bae, of efficacy and safety in a Japanese population. Jeong Gwan Cho, Seung Jung Park, The Heart Center of Chonnam National University Hospital, Gwangju, South Korea 2502-421 Preliminary Angiographic Results of the Novel Polymer-Free Biolimus-A9 Coated Stents for the Learning Objective: identify clinical outcomes of DES in real-world STEMI Treatment of Coronary Artery Lesions - Four- Month Angiographic Follow-Up of the Prospective, Randomized, Multicenter BIOFREEDOM Trial

Ricardo A. Costa, Alexandre Abizaid, Roxana Mehran, Alexandra J. Lansky, Marco A. Magalhaes, Louise Gambone, Helen Parise, Gerhard Schuler, Karl E. Hauptmann, Joachim Schofer, Eberhard Grube, Cardiovascular Research Center / Cardiovascular Research Foundation, Sao Paulo, NY, Brazil, Helios Heart Center, Siegburg, Germany Learning Objective: Demonstrate the efficacy of a novel (third generation) polymer-free DES for inhibiting neointimal proliferation in non-complex de novo coronary lesions JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A193

2502-422 Comparative Antirestenotic Efficacy Of 2502-433 Prediction of 5-year Clinical Outcomes Using the Biodegradable Polymer And Permanent Polymer SYNTAX Score in Patients Undergoing Percutaneous Drug-eluting Stents: The Angiographic Follow-up Coronary Intervention from the SIRolimus-Eluting Results Of The ISAR-TEST-4 Randomized Trial Stent Compared with PacliTAXel-Eluting Stent for Coronary Revascularization (SIRTAX) Trial Sebastian F. Kufner, Robert A. Byrne, Stefanie Schulz, Katrin A. Birkmeier, Klaus Tiroch, Susanne Pinieck, Silvia Hurt, Jürgen Pache, Chrysafios Girasis, Scot Garg, Lorenz Räber, Giovanna Sarno, Marie- Julinda Mehilli, Deutsches Herzzentrum, Technische Universität, angèle Morel, Hector Garcia-Garcia, Patrick W. Serruys, Stephan Munich, Germany, 1. Medizinische Klinik, Klinikum rechts der Isar, Windecker, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Technische Universität, Munich, Germany Netherlands, Department of Cardiology, University Hospital Bern,

Bern, Switzerland Cardiology) (Interventional Learning Objective: evaluate the antirestenotic efficacy of biodegradable polymer stents and permanent polymer stents Learning Objective: evaluate the potential of the SYNTAX score to risk stratify patients with the wide range of coronary artery disease

2502-429 Predictors of Late Restenosis Following Sirolimus- seen in daily clinical practice i2 Summit Eluting Stent Implantation: Serial (8-month and 2-year) Angiographic Follow-up 2502-435 Persistent Benefit From Paclitaxel-Eluting Stent Implantation in Saphenous Vein Grafts: Long-Term Nehiro Kuriyama, Yoshio Kobayashi, Tatsuya Nakama, Daigo Results of the Stenting Of Saphenous Vein Grafts Mine, Mitsuhiro Shimomura, Kensaku Nishihira, Katsumasa (SOS) Trial Nomura, Keiichi Ashikaga, Akihiko Matsuyama, Yoshisato Shibata, Department of Cardiology, Miyazaki Medical Association Hospital, Christopher Lichtenwalter, James A. de Lemos, Owen Obel, Abdul- Miyazaki, Japan, Department of Cardiovascular Science and rahman Riyad Abdel-karim, Michele Roesle, Donald Haagen, Bilal Medicine, Chiba University Graduate School of Medicine, Chiba, Saeed, Joseph K. Bissett, Rajesh Sachdeva, Vassilios V. Voudris, Japan Panagiotis Karyofillis, Biswajit Kar, James Rossen, Panayotis Learning Objective: describe the incidence and predictors of late Fasseas, Peter Berger, Subhash Banerjee, Emmanouil S. Brilakis, restenosis after sirolimus-eluting stent implantation. Veterans Affairs North Texas Healthcare System, Dallas, TX, University of Texas Southwestern Medical Center, Dallas, TX 2502-430 Five-Year Clinical Outcome after Implantation of Learning Objective: Demonstrate that major cardiac adverse events Sirolimus-Eluting Stents versus Paclitaxel-Eluting are frequent after SVG stenting and paclitaxol-eluting stents are Stents in Unselected Patients with Coronary artery associated with better long-term clinical outcomes than BMS in SVG Disease: KOMATE DES Registry lesions.

Young-Guk Ko, Jung-Sun Kim, Donghoon Choi, Myeong-Ki Hong, 2502-436 Plaque Sealing with Paclitaxel-Eluting Stents for the Yangsoo Jnag, Pil Ki Min, Young Won Yoon, Bum-Kee Hong, Byoung Treatment of Moderate Non-Significant Saphenous Kwon Lee, Hyuck Moon Kwon, Severance Cardiovascular Hospital, Vein Graft Lesions. Three-Year Follow-Up of the Seoul, South Korea, Gangnam Severance Hospital, Seoul, South VELETI (Moderate Vein Graft Lesion Stenting with Korea the Taxus Stent and Intravascular Ultrasound) Trial Learning Objective: demonstrate long-term outcomes of first generation DES Josep Rodés-Cabau, Olivier F. Bertrand, Eric Larose, Jean-Pierre Déry, Stéphane Rinfret, Rodrigo Bagur, Guy Proulx, Can M. Nguyen, Mélanie Côté, Marie-Claude Landcop, Jean-Rock Boudreault, 2502-431 Late-term Safety and Efficacy Outcomes Following Treatment with Zotarolimus-Eluting Stents: 5-year Jacques Rouleau, Louis Roy, Onil Gleeton, Gérald Barbeau, Bernard Noël, Javier Courtis, Gilles R. Dagenais, Jean-Pierre Després, Robert Results of the Pooled Endeavor Trials Program DeLarochellière, Quebec Heart and Lung Institute, Laval University, David E. Kandzari, Martin B. Leon, William Wijns, Ian T. Meredith, Quebec, QC, Canada Jean Fajadet, Donald E. Cutlip, Laura Mauri, Scripps Clinic, La Learning Objective: Evaluate the role of plaque sealing in Jolla, CA saphenous vein grafts. Learning Objective: Evaluate 5-year efficacy and safety outcomes from the Endeavor Pooled Clinical Trials program. 2502-437 Comparison of a Paclitaxel Eluting Stent with Biodegradable Polymer and Glycolix Coating versus 2502-432 Five Year Clinical Results from ENDEAVOR III: A Bare Metal Stent Design: First Presentation of 9 Randomized Comparison of the Zotarolimus-Eluting Months Clinical and Angiographic Outcome of the versus Sirolimus-Eluting Stents in De Novo Native Randomized, Multicenter and Controlled EUCATAX Coronary Lesions Trial(NCT00825279).

David E. Kandzari, Laura Mauri, Jeffrey Popma, Mark A. Turco, Alfredo E. Rodriguez, Federico C. Vigo, Alejandro Delacasa, Victor Charles O’Shaunessy, Paul A. Gurbel, Peter J. Fitzgerald, Martin B. Bernardi, Marcelo Bettinotti, Omar Santaera, Valeria Curotto, Carlos Leon, Scripps Clinic, La Jolla, CA Fernandez-Pereira, Bibiana Rubilar, Juan Mieres, David Antoniucci, Igor F. Palacios, Otamendi Hospital, Buenos Aires, MA, Argentina, Learning Objective: Evaluate if disparity in early angiographic Massachusetts General Hospital, Boston, MA measures translates to clinically relevant differences over late-term (5 year) follow-up. Learning Objective: Biodegradable polymers and glicolix coating are both associated with low complications. The purpose was to compare this novel DES technology with BMS in a real world population. A194 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2502-438 Vascular Responses to a Newly Developed Coronary 2502-447 Impact of Total Sirolimus-Eluting Stent Length Stent (Nobori) Coated with the Bioabsorbable on Three-Year Clinical Outcomes in the j-Cypher Polymer, Polylactic Acid and Biolimus A9 Registry

Hitomi Hagiwara, Masashige Sasaki, Yoshiaki Hiraishi, Hisako Terao, Shinichi Shirai, Takeshi Kimura, Masakiyo Nobuyoshi, Takeshi Junji Kimura, Katsumi Inoue, TERUMO Corporation, Kanagawa, Morimoto, Kenji Ando, Yoshimitsu Soga, Kyohei Yamaji, Katsuhiro Japan, Kurashiki Central Hospital, Japan Kondo, Koyu Sakai, Takeshi Arita, Masahiko Goya, Masashi Iwabuchi, Hiroyoshi Yokoi, Hideyuki Nosaka, Kazuaki Mitsudo, Learning Objective: evaluate long-term safety and efficacy of the j-Cypher registry investigators, Kokura Memorial Hospital, newly developed DES (Nobori) in porcine coronary arteries. Kiktayushu, NY, Japan

2502-439 NOBORI Female Study- Clinical Outcomes at 12 Learning Objective: interpret that full lesion cover stent implantation Months was not the risk for stent thrombosis, but multiple stent implant for multiple lesion was the risk for stent thrombosis. Gian Battista Danzi, Sr., Marie Claude Maurice, Fina Mauri, Marcus Wiemer, Dragan Sagic, Farzin Fath-Ordoubadi, Antonio Serra, David 2502-449 Influence of Non-Uniform Stent Expansion on Hildick-Smith, René Konig, Didier Carrie, Javier Goicolea Ruigomez, Neointimal Hyperplasia after Bare-Metal and Miodrag Ostojic, Marcus Hennersdorf, Stefan Hoffmann, Ospedale Zotarolimus-Eluting Stents Implantation

i2 Summit Maggiore Policlinico, Milan, Italy Daisaku Nakatani, Katsuhisa Waseda, Hiromasa Otake, Junya Learning Objective: Assess the specificity in PCI in female patients Ako, Paul G. Yock, Peter J. Fitzgerald, Yasuhiro Honda, Stanford and evaluate the new stents with biodegradable polymer. University Medical Center, Palo Alto, CA (Interventional Cardiology) 2502-443 Endothelial Dysfunction After Sirolimus-Eluting Learning Objective: We demonstrated that stent expnasion might Stent Implantation Is Not Persistent affect neointimal hyperplasia

Hideki Kitahara, Yoshio Kobayashi, Nakabumi Kuroda, Issei Komuro, 2502-450 Neointimal Coverage on the Drug-Eluting Stent Chiba University Graduate School of Medicine, Chiba, Japan Struts Crossing the Side-Branch Vessels : An Optical Learning Objective: demonstrate that endothelial dysfunction after Coherence Tomography Study sirolimus-eluting stent implantation is not persistent. Ae-Young Her, Myeong-Ki Hong, Jae-Min Shim, Jung-Sun Kim, Young- Stent Fracture and Angiographic Peri-Stent Guk Ko, Donghoon Choi, Yangsoo Jang, Yonsei Cardiovascular 2502-444 Center and Cardiovascular Research Institute, Seoul, YT, South Abnormal Finding After Sirolimus-eluting Stent Korea Implantation Learning Objective: The present OCT study showed the presence of Kazushige Kadota, Kazuaki Mitsudo, Tsuyoshi Goto, Satoki Fujii, neointimal coverage on the stent struts crossing the side-branch Hiroyuki Yamamoto, Harumi Katoh, Naoki Oka, Yasushi Fuku, Shingo vessels and different pattern of neointimal coverage according to Hosogi, Yoshiharu Nishibori, Akitoshi Hirono, Takeshi Maruo, Hiroyuki different DES types. Tanaka, Seiji Habara, Yoshikazu Shigemoto, Daiji Hasegawa, Ippei Kosedo, Hiroshi Tasaka, Masao Imai, Mana Kusunose, Yoji Okamoto, 2502-451 The Impact of Hinge Motion on In-Stent Restenosis Suguru Otsuru, Naoki Saito, Kentaro Shibayama, Yuki Tsujimoto, after Sirolimus-Eluting Stent implantation Kurashiki Central Hospital, Kurashiki, Japan Yasushi Ino, Hironori Kitabata, Atsushi Tanaka, Takashi Kubo, Learning Objective: demonstrate the prevalence of stent fracture and Shigeho Takarada, Takashi Tanimoto, Kennichi Komukai, Kouhei angiographic peri-stent abnormal findinds and their clinical impact Ishibashi, Keishi Ookouchi, Akio Kuroi, Aiko Shimokado, Kumiko Hirata, Masato MIzukoshi, Toshio Imanishi, Takashi Akasaka, High Pressure Post-Dilatation Procedure May Induce 2502-445 Wakayama Medical University, Wakayama, Japan Neointimal Coverage After Silolims-Eluting Stent Implantation Learning Objective: Measuring angle in the target lesion was performed easily and quickly before PCI. Selection of DES types Masayuki Taniike, Masami Nishino, Takeshi Masaki, Naoki Mori, based on angle before PCI may be effective on more reduction of Daisuke Nakamura, Takahiro Yoshimura, Yasuharu Lee, Shimpei ISR after DES implantation. Nakatani, Masahiko Hara, Nobuhiko Makino, Yasuyuki Egami, Hiroyasu Kato, Ryu Shutta, Hitoshi Yamaguchi, Jun Tanouchi, Yoshio 2502-452 Two Years Clinical Outcomes after Large Coronary Yamada, Division of Cardiology, Osaka Rosai Hospital, Osaka, Japan Stent (4.0mm) Placement: Comparision of Bare- Learning Objective: demonstrate the useful procedure of stent Metal Stent versus Drug-Eluting Stent implantaion without late stent thrombosis. Chang-Wook Nam, Yun-Kyeong Cho, Seung-Ho Hur, Kwon-Bae Kim, Hyun-Tae Kim, Young-Jo Kim, Jong-Seon Park, Sang-Hee Lee, Geu-Ru Difference in Speed of Neointimal Proliferation 2502-446 Hong, Ung Kim, Sang-Hoon Seol, Tae-Hyun Yang, Doo-Il Kim, William Following Sirolimus-Eluting Stent Implantation F Fearon, Keimyung University Dongsan Hospital, Daegu, South According to Clinical and Lesion Characteristics Korea, Stanford University Medical Center, Palo Alto, CA Hideo Amano, Kenji Wagatsuma, Mikihito Toda, Hideo Nii, Yasuto Uchida, Learning Objective: This study was aimed to identify the real value Jyunichi Yamazaki, Division of interventional Cardiology, Cardiovascular of DES in large vessel coroanry disease, compared to BMS Center, Toho University Omori Medical Center, Tokyo, Japan Learning Objective: Neointimal proliferation was prone to occur early after SES implantation in calcification of the coronary artery,thoracic aorta, and late was prone to occur in stent fracture. JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A195

2502-453 Impact of Optimal Stent Expansion on Outcomes of 2502-459 Lack of Value of Traditional Predictors for Restenosis Drug-eluting Stent Implantation for Small Coronary After a Recurrent Drug-Eluting Stent Failure Vessels(≤2.75mm) as Assessed with Intracoronary Gabriel Maluenda, Manuel A. Gonzalez, Cedric Delhaye, Itsik Ben-Dor, Ultrasound Michael A. Gaglia, Nicholas N. Hanna, Kohei Wakabayashi, Asmir I. Hiroshi Yamaguchi, Nobuhiko Atsuchi, Junichiro Takaoka, Akihiro Syed, Rebecca Torguson, Zhenyi Xue, William O. Suddath, Kenneth Miyamura, Takahiro Shirasawa, Ryuma Nakao, Junko Yoshinaga, M. Kent, Lowell F. Satler, Joseph Lindsay, Augusto D. Pichard, Ron Yoshihiko Atsuchi, Tenyoukai Central Hospital, Kagoshima, Japan Waksman, Washington Hospital Center, Washington, DC Learning Objective: demonstrate that optimal DES stenting using Learning Objective: Recognize the lack of predictors for recurrent IVUS for small coronary artery diseases might result in favorable DES restenosis and the complexity of treating this population long-term outcomes. Cardiology) (Interventional 2502-460 Reintervention for Drug Eluting Stent Restenosis: Is 2502-455 Gender Differences In Long-Term Clinical Outcome There a Preferred Strategy? After Percutaneous Revascularisation Of Multivessel i2 Summit Maria Alexandra Rodriguez, Aaron Giltner, Michael P. Savage, Paul Coronary Artery Disease: Insights From Autax Walinsky, David Ogilby, Babu R. Jasti, David L. Fischman, Thomas Registry Jefferson University Hospital, Philadelphia, PA Mariann Gyongyosi, Rosa Badr-Eslam, Susanne Winkler, Noemi Learning Objective: Identify the optimal management for patients Nyolczas, Irene Lang, Günter Christ, Gerhard Kreiner, Dietmar who present with a drug-eluting stent (DES) restenosis. Compare the Glogar, Medical University of Vienna, Vienna, Austria outcomes of patients treated with the same vs. an alternate DES. Learning Objective: distinguish the gender differences in long- term outcome of implantation of drug-eluting stents in multivessel 2502-461 Thin Versus Thick Strut Stent For Percutaneous diseases Coronary Intervention Using Bare Metal Stents: Insights from the NHLBI PCI Dynamic Registry Low-Density Lipoprotein Cholesterol Levels 2502-456 Sripal Bangalore, Faith Selzer, Vankeepuram S. Srinivas, David O. Affect Peristent Plaque Tissue Characteristics in Williams, David P. Faxon, Brigham and Women’s Hospital, Boston, MA Patients Treated with Drug-Eluting Stents: A Serial Volumetric Analysis Using Quantitative Integrated Learning Objective: Evaluate the efficacy and safety of thin versus Backscatter Intravascular Ultrasound (IB-IVUS) thick strut bare metal stents

Mitsuaki Endo, Kiyoshi Hibi, Noriaki Iwahashi, Naoki Nozawa, Jun 2502-462 Stainless Steel Versus Non-Stainless Steel Stents For Okuda, Kengo Tsukahara, Masami Kosuge, Toshiaki Ebina, Tsutomu Percutaneous Coronary Intervention Using Bare Metal Endo, Satoshi Umemura, Kazuo Kimura, Saiseikai Yokohama-City Stents: Findings from the NHLBI PCI Dynamic Registry Southern Hospital, Yokohama, Japan, Yokohama City University Medical Center, Yokohama, Japan Sripal Bangalore, Faith Selzer, David O. Williams, David P. Faxon, Brigham and Women’s Hospital, Boston, MA Learning Objective: characterize peristent plaque tissue changes and investigate the relationship between lipid profiles and peristent Learning Objective: Evaluate the role of stent material on the risk of plaque compositions using quantitative integrated backscatter clinical outcomes in patients treated with a bare metal stent intravascular ultrasoun 2502-463 Impact of Myocardial Bridge on Clinical Outcome: 2502-457 Impact of High Density Lipoprotein Levels on In Cases of Sirolimus-eluting-stent implantation on Clinical Outcomes in Patients With Drug-eluting Left Anterior Descending Coronary Artery Stents Daiji Hasegawa, Kazushige Kadota, Yuki Tsujimoto, Kentaro Inder M. Singh, Ryan J. Lennon, Thomas G. Allison, Abhiram Shibayama, Naoki Saito, Suguru Otsuru, Yoji Okamoto, Mana Prasad, Mandeep Singh, David R. Holmes, Jr., Amir Lerman, Kusunose, Masao Imai, Hiroshi Tasaka, Ippei Kosedo, Yoshikazu Charanjit S. Rihal, Mayo Clinic (Division of Cardiovascular Shigemoto, Seiji Habara, Hiroyuki Tanaka, Tekeshi Maruo, Akitoshi Diseases), Rochester, MN Hirono, Yoshiharu Nishibori, Shingo Hosogi, Yasushi Fuku, Naoki Oka, Harumi Katoh, Hiroyuki Yamamoto, Satoki Fujii, Tsuyoshi Goto, Learning Objective: Evaluate the impact of high-density lipoprotein Kazuaki Mitsudo, Kurashiki Central Hospital, Kurashiki, Japan levels on clinical outcomes in patients with drug-eluting stents Learning Objective: demonstrate the prevalence of myocardial 2502-458 Both Hypoglycemia and Hyperglycemia are bridging before and after implantation sirolimus-eluting-stent on left Associated With Increased Incidence of in-Stent anterior descending coronary and the late outcome of lesions Restenosis in Patients Undergoing Elective Coronary Angioplasty 2502-464 Clinical Presentation Of In-stent Restenosis And Angiographic Confirmed Stent Thrombosis In Annunziata Nusca, Giuseppe Patti, Francesco Marino, Fabio Patients Treated With Bare Metal Or Drug-eluting Mangiacapra, Laura Gatto, Marco Miglionico, Rosetta Melfi, Andrea Stents. From Western Denmark Heart Registry D’Ambrosio, Germano Di Sciascio, Campus Bio-Medico University, Rome, Italy Per Thayssen, Lisette Okkels Jensen, Anne Kaltoft, Hans Henrik Tilsted, Michael Maeng, Evald Hoej Christiansen, Knud N. Hansen, Learning Objective: to demonstrate that hypoglycemia and Jan Ravkilde, Jan Ravkilde, Lars Krusell, Jens F. Lassen, Leif hyperglycemia are associated with increased incidence of in-stent Thuesen, Odense University Hospital, Odense, Denmark restenosis Learning Objective: Target lesion revascularization and clinical presentation A196 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2502-489 Impact of Target Lesion Revascularization on Death, 2502-494 In-Segment Angiographic Measurement at Follow- Myocardial Infarction and Stroke in Patients With up after Sirolimus-Eluting Stent Implantation is Sirolimus-eluting stent Implantation : Insights From Strongly Associated with Late Restenosis, Not with j-CYPHER Registry Stent Thrombosis

Kazuhiro Nakao, Mitsuru Abe, Takuya Taniguchi, Takafumi Yamane, Shinichiro Miyazaki, Yoshikazu Hiasa, Koichi Kishi, Takefumi Yukiko Oe, Futoshi Yamanaka, Nobuhito Yagi, Nobuaki Kokubu, Takahashi, Yudai Yano, Hirotoshi Chen, Keitaro Mahara, Riyo Ogura, Yoichiro Kasahara, Yu Kataoka, Yoritaka Otsuka, Takeshi Morimoto, Shinobu Hosokawa, Ryuji Ohtani, Tokushima Red Cross Hospital, Kazuaki Mitsudo, Takeshi Kimura, Hiroshi Nonogi, National Komatsushima, Japan Cardiovasculer Center, Osaka, Japan Learning Objective: distinguish that the moderate progression in the in- Learning Objective: We evaluate the significance of target lesion segment area at 9-month follow-up angiography was strongly associated revascularization after sirolimus-eluting stents implantation for with late restenosis, but not with stent thrombosis after 1-year. adverse outcome. SES restenosis was also relatively benign event in DES era. 2502-495 Optical Coherence Tomography in Unprotected Left Main Coronary Artery Stenting 2502-490 Impact of Cilostazol on Restenosis After Cobalt- Chromium Alloy Stent Implantation in High-Risk Guido Parodi, Akiko Maehara, MD, Gabriele Giuliani, MD, Takashi i2 Summit Patients Kubo, MD, Gary Mintz, MD, Ruben Vergara, MD, Angela Migliorini, MD, Renato Valenti, MD, Nazario Carrabba, MD, David Antoniucci, Hiroshi Ueda, Hiroki Sakamoto, Yuichi Kawase, Shinsaku MD, Careggi Hospital, Florence, Italy, Cardiovascular Research Foundation, New York, NY

(Interventional Cardiology) Shimamoto, Tomoe Murakami, Takashi Tamura, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan Learning Objective: Evaluate Learning Objective: describe the different effects of cilostazol on restenosis after cobalt-chromium alloy stent implantation in high- 2502-496 Left Main Culprit Lesion Myocardial Infarction risk compared to low-risk patients in Patients with Prior Coronary Bypass Grafting: Percutaneous Coronary Intervention Outcomes. 2502-491 Coronary Plaque Components Assessed by Virtual Histology-Intravascular Ultrasound Are Not William B. Hillegass, Jr., Vijay K. Misra, Brigitta C. Brott, John C. Associated With Neointimal Hyperplasia in Patients Messenger, LLoyd W. Klein, Tracy Y. Wang, Silvio E. Papapietro, David Dai, Fang-Shu Ou, Gilbert J. Zoghbi, ACC-NCDR CathPCI Who Underwent Drug-Eluting Stent Implantation Registry Participating Centers, University of Alabama at Birmingham, Young Joon Hong, Myung Ho Jeong, Yun Ha Choi, Eun Hye Ma, Birmingham, AL, Duke University Medical Center, Durham, NC Jum Suk Ko, Min Goo Lee, Keun Ho Park, Doo Sun Sim, Nam Sik Learning Objective: Describe how prior CABG modifies the risk of Yoon, Hyun Ju Youn, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, PCI in left main culprit lesion myocardial infarction. Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang, Heart Center of Chonnam National University Hospital, Real World Application of Stenting of Unprotected Gwangju, South Korea 2502-497 Left Main Coronary Stenosis: A Single-Center Learning Objective: to evaluate the relation between neointimal Experience hyperplasia and plaque components after DES implantation Calvin Leung, Timothy C. Ball, Jeremiah R. Brown, Mandeep S. Sidhu, James T. Devries, John F. Robb, Aaron V. Kaplan, David J. 2502-492 Prognostic Impact of Preprocedural Levels of C-Reative Protein, Lipoprotein (a) and Homocysteine Malenka, Craig A. Thompson, Dartmouth-Hitchcock Medical Center, Lebanon, NH on the Long-Term Clinical Outcomes in Patients with Drug-Eluting Stents Implantation Learning Objective: Identify that percutaneous coronary intervention stenting of left main coronary artery is a viable option to coronary Won-Jang KIM, Duk-Woo Park, Jong-Sun Park, Jun-Hyuk Oh, Hye-Gun artery bypass grafting Song, Jeong-Min Ahn, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Jae-Joong Kim, Seong-Wook Park, Seung-Jung 2502-498 Comparison of Single Versus Two Stent Techniques Park, Asan Medical Center, Seoul, South Korea in Treatment of Unprotected Left Main Coronary Learning Objective: To evaluate the prognotic impact of Artery Stenosis preprocedural levels of C-reative protein, lipoprotein (a), and homocystein on long-term clinical outcomes after successfu Won-Jang KIM, Young-Hak Kim, Duk-Woo Park, Soo-Jin Kang, Seung- implantation of drug-eluting stent Whan Lee, Cheol Whan Lee, Jae-Joong Kim, Seong-Wook Park, Seung-Jung Park, Asan Medical Center, Seoul, South Korea 2502-493 Optical Coherence Tomography Findings of Lesion Learning Objective: To compare single- versus two-stent technique with Very Late Restenosis after Bare Metal Stent in patients with unprotected left main coroanry artery disease who Implantation received drug-eluting stent

Maoto Habara, Mitsuyasu Terashima, Yoshihiro Ko, Tsuyoshi Ito, 2502-500 Multicentric Prospective Spanish Registry Of Left Soichiro Ebisawa, Tairo Kurita, Nobuyoshi Tanaka, Kenya Nasu, Main Treatment: Renacimiento Registry Masashi Kimura, Tatsuya Ito, Yoshihisa Kinoshita, Mariko Ehara, Etsuo Tsuchikane, Yasushi Asakura, Osamu Kato, Takahiko Suzuki, Jose Antonio Baz, Sr., Agustin Albarrán, Josepa Mauri, Eduardo Toyohashi Heart Center, Toyohashi, AL, Japan Pinar, Renacimiento Investigators, Seccion de Hemodinamica y Learning Objective: distinguish the difference of the mechanism cardiología intervencionista, Madrid, Spain between eraly restenosis and very late restenosis of bare-metal stent Learning Objective: describe JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A197

2502-501 What is the Best PCI Strategy with Sirolimus-Eluting 2502-508 A Novel Approach to Screening for Sudden Cardiac Stent in Unprotected Left Main Coronary Arteries? Death in Young Adults Utilizing a Stratified Method With ECG and Echo Kensuke Takagi, Ken Kujiraoka, Jun Tanno, Yusuke Fujino, Miwako Tsukiji, Naoyuki Kurita, Jin Yokoyama, Sunao Nakamura, New Tokyo Joseph C. Marek, Sarah A. Marek, Kathleen A. Marek, Frank Hospital, Chiba, Japan Zimmerman, Johneen Davis, Midwest Heart Foundation, Lombard, IL Learning Objective: Describe the best strategy of Sirolimus-eluting Learning Objective: evaluate young adults at risk for sudden cardiac stent in patients with left main coronary artery disease death more efficiently with lower false positive ECGs

2502-502 Comparison of Efficacy and Four-Year Durability 2502-509 Quality performance over time in Acute Coronary between Sirolimus-Eluting Stent and Paclitaxel- Syndrome patients admitted to a University Hospital Cardiology) (Interventional Eluting Stent in Unprotected Left Main Coronary Arteries: Multicenter Registry in Asia Irfan Hameed, Nandu Gourineni, Sharon Van Riper, Eva-Kline Rogers,

Jim Froehlich, Elizabeth Jackson, Kim Eagle, University of Michigan, i2 Summit Sunao Nakamura, Hisao Ogawa, Jang-Ho Bae, Yeo Hans Ann Arbor, MI Cahyadi, Wasan Udayachalerm, Damras Tresukosol, Sudaratana Learning Objective: To evaluate the trends in ACS care & outcomes. Tansuphaswadikul, New Tokyo Hospital, Chiba, Japan At the conclusion of this presentations, participants will be able to Learning Objective: Describe the clinical efficacy and durability of understand theimportance of long term care. SES and PES implantation in patients with unprotected left main coronary arteries. 2502-510 Development of Two Registry-based Measures Suitable for Characterizing Hospital Performance on 2502-503 In-Hospital And One Year Survival Of Patients 30-day All-Cause Mortality Rates Among Patients Undergoing Unprotected Left Main Coronary Artery Undergoing Percutaneous Coronary Intervention Stenting Who Are Not Candidates For Coronary Artery Bypass Surgery Jeptha P. Curtis, Lori Geary, Yongfei Wang, Jersey Chen, Elizabeth E. Drye, Laura M. Grosso, Geoffrey Schreiner, John A. Spertus, John William Ng, Robert Lundstrom, Edward McNulty, Kaiser-San Rumsfeld, William S. Weintraub, Sharon-Lise T. Normand, Harlan M. Francisco Medical Center, San Francisco, CA Krumholz, Yale University School of Medicine, New Haven, CT Learning Objective: demonstrate feasibilty of unprotected left main Learning Objective: Understand the attributes and performance stenting in nonsurgical candidate of two registry-based models of PCI mortality that are suitable for characterizing hospital performance 2502-504 Five-Year Durability of Sirolimus-Eluting Stent in Patients with Unprotected Left Main Coronary 2502-514 A Novel Risk Score for Percutaneous Coronary Arteries Compared with Bare Metal Stents: Intervention Outcome Assessment: Weighing the Multicenter Registry in Asia Importance of Complications After Procedure

Sunao Nakamura, Hisao Ogawa, Jang-Ho Bae, Yeo Hans Gabriel Maluenda, Cedric Delhaye, Michael A. Gaglia, Manuel A. Cahyadi, Wasan Udayachalerm, Damras Tresukosol, Sudaratana Gonzalez, Itsik Ben-Dor, Nicholas N. Hanna, Kohei Wakabayashi, Tansuphaswadikul, New Tokyo Hospital, Chiba, Japan Rebecca Torguson, Zehnyi Xue, William O. Suddath, Lowell F. Satler, Kenneth M. Kent, Joseph M. Lindsay, Augusto D. Pichard, Ron Learning Objective: Describe the clinical efficacy and durability of Waksman, Washington Hospital Center, Washington, DC SES implantation in patients with unprotected left main coronary arteries. Learning Objective: To identify the significance of post-procedural complications in the long term outcomes 2502-506 Assessing PCI Outcomes at 30 Days: Are We Moving Too Fast? A Report from the NHLBI 2502-515 Is it Safe to Discharge Patients on the Same Day Dynamic Registry after Elective Percutaneous Coronary Intervention?

Mark J. Ricciardi, Warren K. Laskey, Faith Selzer, Oscar Marroquin, Andra M. Popescu, Leo Marcoff, Gilbert A. Leidig, Dan Murphy, Elizabeth Holper, Lakshmi Venkitachalam, Sheryl Kelsey, University William S. Weintraub, Ehsanur Rahman, ChristianaCare Health of New Mexico, Albuquerque, NM, University of Pittsburgh, Systems, Newark, DE Pittsburgh, PA Learning Objective: To identify potential candidates for early Learning Objective: Distinguish important difference between in- discharge after elective PCI. hospital and 30 day outcomes after PCI 2502-516 The Changing Profile of Medicare Patients 2502-507 The Canary in the Coal Mine: Percutaneous Receiving Drug-Eluting Stents after Myocardial Coronary Intervention Rates Mirror Decline in CABG Infarction Volume. Trends in Coronary Revascularization in the Jerome Federspiel, Sally C. Stearns, Laura P. D’Arcy, Kristin L. Reiter, U.S. From 2001-2008 Brett C. Sheridan, Joseph S. Rossi, UNC School of Public Health, Robert F. Riley, Creighton W. Don, Wayne Powell, Larry S. Dean, Chapel Hill, NC, UNC School of Medicine, Chapel Hill, NC University of Washington Medical Center, Seattle, WA, Society for Learning Objective: Identify how interventionalists have changed the Cardiovascular Angiography and Interventions, Washington, DC profile of patients receiving DES. Learning Objective: describe trends in PCI within the U.S. from 2001-2008 A198 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2502-517 Do Patients Undergoing Elective Percutaneous 2502-523 The Impact of Body Mass Index on the One year Coronary Intervention Understand Their Risk for Outcome of Patients treated by PCI with Biolimus- Future Myocardial Infarction? and Sirolimus- eluting stents from the LEADERS Trial. Alexis Ann D’Elia, Abdul Moiz Hafiz, Srihari S. Naidu, Thomas Chengot, Kevin P. Marzo, Winthrop University Hospital, Mineola, NY Giovanna Sarno, Scot Garg, Yoshinobu Onuma, Pawel Buszman, Axel Linke, Thomas Ischinger, Volker Klauss, Franz Eberli, Roberto Learning Objective: Determine if patients understand the risk Corti, William Wijns, Marie-Claude Morice, Carlo Di Mario, Pedro for future myocardial infarctions after percutaneous coronary Eerdmans, Hector M. Garcia-Garcia, Gerrit-Anne van Es, Dick intervention Goedhart, Ton de Vries, Peter Jüni, Bernhard Meier, Stephan Windecker, Patrick Serruys, Thoraxcenter Erasmus MC, Rotterdam, Primary Percutaneous Coronary Intervention In 2502-518 The Netherlands a Real Life Population: Comparison With Trial Findings Learning Objective: appreciate that BMI has an impact on the cardiac events post-PCI Lars Jakobsen, Troels Niemann, Torsten Toftegaard Nielsen, Niels Thorsgaard Pedersen, Søren Paaske Johnsen, Department 2502-524 Percutaneous Coronary Intervention In Patients of Clinical epidemiology, Aarhus University Hospital, Aarhus, PE, Post Surgical Revascularisation

i2 Summit Denmark, Department of Internal Medicine & Cardiology, Herning Hospital, Herning, Denmark Scot Garg, Giovanna Sarno, Juan Luis Gutiérrez-Chico, Joanna Wykrzykowska, Chrysafios Girasis, Peter de Jaegere, Arie-Peter Learning Objective: describe differences in patients characteristics, Kappetein, Ron van Domburg, Patrick Serruys, Erasmus Medical (Interventional Cardiology) care and patient outcomes between patients receiving primary PCI Center, Rotterdam, The Netherlands in routine clinical setting and patients participating in the DANAMI-2 trial Learning Objective: appreciate that despite PCI, patients having secondary revascularisation are at high risk of mortality,reinforcing 2502-520 Twenty-Four-Hour In-Hospital Interventional the importance of maintaining secondary prevention post primary Cardiology Team and Impact on Door-to-Balloon revascularisation Times: Surpassing the American College of Cardiology Door-to-Balloon Alliance Benchmark 2502-531 Short- and Long-term Prognostic Impacts of Metabolic Syndrome and Chronic Kidney Disease in M. Fuad Jan, Anthony C. DeFranco, Naoyo Mori, Angela Schlemm, Patients after Acute Myocardial Infarction Anjan Gupta, Suhail Allaqaband, Tanvir Bajwa, Aurora Cardiovasc Svcs, Aurora Sinai/St. Luke’s Med Ctrs, Univ Wisconsin Sch Med Nobuaki Kokubu, Yoritaka Otsuka, Yukiko Oe, Takafumi Yamane, & Public Health-MCC, Milwaukee, WI, Center for Urban Population Futoshi Yamanaka, Nobuhito Yagi, Yoichiro Kasahara, Yu Kataoka, Health, University of Wisconsin-Milwaukee, Milwaukee, WI Yoichi Goto, Hiroshi Nonogi, Sapporo Medical University, Sapporo, Japan, National Cardiovascular Center, Suita, Japan Learning Objective: demonstrate that a 24x7 in-hospital interventional cardiology program can effectively shorten the Learning Objective: understand short- and long-term prognostic door-to-balloon time and reperfuse a greater percentage of STEMI impacts of metabolic syndrome and chronic kidney disease in patients than the current ACC goal. patients after acute myocardial infarction

2502-521 Randomized Comparison of Transradial Coronary 2502-532 Use of Drug-Eluting Stents Varies According to Type Angiography via Right or Left Radial Artery of Health Insurance Approaches Michael Angelo Gaglia, Jr., Rebecca Torguson, Manuel A. Gonzalez, Yumiko Kanei, Navin C. Nakra, Michael C. Liou, Hugo Rosero, Zhenyi Xue, Itsik Ben-Dor, Sara D. Collins, Asimir I. Syed, Gabriel Ramesh Gowda, Tak W. Kwan, John T. Fox, Beth Israel Medical Maluenda, Cedric Delhaye, Kohei Wakabayashi, Nicholas Hanna, Center, New York, NY William O. Suddath, Kenneth M. Kent, Lowell F. Satler, Augusto D. Pichard, Ron Waksman, Washington Hospital Center, Washington, DC Learning Objective: describe the difference of right radial approach and left radial approach in coronary angiogram. Learning Objective: Describe the impact of health insurance type upon the likelihood of receiving a drug-eluting stent. 2502-522 A New Tool For The Risk Stratification Of Patients With Complex Coronary Artery Disease: The Clinical 2502-533 Long-term Bleeding in Patients on Prolonged Dual Syntax Score Oral Antiplatelet Therapy after DES Implantation: Prevalence, Predictors, and Prognostic Implications Scot Garg, Giovanna Sarno, Chrysafios Girasis, Hector M. Garcia- Garcia, Joanna Wykrzykowska, Keith D. Dawkins, Patrick W. Serruys, Roberta Rossini, Giuseppe Musumeci, Corrado Lettieri, Giuseppe Thoraxcenter, ErasmusMC, Rotterdam, The Netherlands Biondi Zoccai, Tamar Nijaradze, Nicola Cicorella, Nikoloz Lortkipanidze, Michele Romano, Giuseppe Tarantini, Antonello Learning Objective: Appreciate the need for new risk scores Gavazzi, Dominick J. Angiolillo, Ospedali Riuniti di Bergamo, including both angiographic and clinical variables for patients Bergamo, Italy, University of Florida-Shands Jacksonville, undergoing PCI. Jacksonville, FL Learning Objective: Identify the predictors and the prognostic implications of bleeding in patients on prolonged dual antiplatelet therapy JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A199

2502-534 Impact of Cardiac Tamponade During PCI on Short 2503-422 A Randomized Comparison of Sirolimus- Versus and Long Term Survival Paclitaxel-Eluting Stent for Treatment of Bifurcation Lesions by Single Stent and Kissing Ballooning: Ioannis A. Stathopoulos, Gary Roubin, Georgia Panagopoulos, Results of SINGLE KISS trial Konstandinos Kossidas, Marcelo Jimenez, Ej Kwak, Monica Losquadro, Howard Cohen, Kirk Garratt, New York University, Ny, Ny, Kenya Nasu, Yuji Oikawa, Tadanori Aizawa, Takahiko Suzuki, Single Lenox Hill Hospital, Ny, Ny Kiss Trial Investigators, Toyohashi Heart Center, Toyohashi, AL, Learning Objective: understand incidence, management, short and Japan, The Cardiovascular Hospital, Minato-ku, AL, Japan long term outcome after tamponade complicating PCI Learning Objective: understand the efficacy of single stent strategy for coronary bifurcation lesions (Interventional Cardiology) (Interventional 2503 INTRAVASCULAR DIAGNOSTICS AND COMPLEX 2503-429 Three-year Clinical and Angiographic Outcomes LESIONS after implantation of Sirolimus-Eluting Stent with Monday, March 15, 2010, 9:30 a.m. - 10:30 a.m. T-stenting Technique in Coronary Bifurcation Lesions i2 Summit Georgia World Congress Center, Hall B5 from j-Cypher Registry. Presentation Hour: 9:30 a.m. - 10:30 a.m. Toshihiro Tamura, Takeshi Kimura, Kazuaki Mitsudo, Takeshi CME/CE Hours: 1 Morimoto, Kazushige Kadota, Yasuhiko Hayashi, Masakiyo Nobuyoshi, on behalf of the j-Cypher Registry investigators, Kyoto 2503-418 Systemic Double Stenting versus Simple Provisional University Hospital, Kyoto, Japan T-stenting for True Bifurcation Lesions of Left Main Learning Objective: to clarify the safety and efficacy of T-stenting Coronary Artery Disease Using Drug-Eluting Stents: technique in bifurcation lesions Multicenter Registry in Asia First-In-Man IVUS Findings Using the Medtronic Sunao Nakamura, Hisao Ogawa, Jang-Ho Bae, Yeo Hans 2503-430 Cahyadi, Wasan Udayachalerm, Damras Tresukosol, Sudaratana Bifurcation Stent in Patients with Coronary Tansuphaswadikul, New Tokyo Hospital, Chiba, Japan Bifurcation Lesions Learning Objective: Suggest provisional T-stenting of the side Kenji Sakata, Bon-Kwon Koo, Daisaku Nakatani, Katsuhisa Waseda, branch is a feasible strategy associated with low MACE and low TLR Junya Ako, Paul G. Yock, Yasuhiro Honda, Robert Whitbourn, in patients with left main trunk disease. Stephen Worthley, Ian Meredith, Peter J. Fitzgerald, BRANCH study investigators, Stanford University Medical Center, Stanford, CA 2503-419 Higher Restenosis At The Main And Side Branch Learning Objective: demonstrate Medtronic Bifurcation Stent Ostium Was Explained By Both Inadequate Stent appears to be feasible yielding adequate stent coverage and Expansion And Increased Neointimal Proliferation expansion at carina and side branch ostium After Coronary Bifurcation Stenting: Serial Intravascular Ultrasound Study 2503-431 Single Sirolimus Versus Paclitaxel eluting Stent Implantation With Kissing Balloon Technique In The Hyeon-Cheol Gwon, Young Bin song, Joo Yong Hahn, Jin Ho Choi, Treatment Of Non-left Main Bifurcation. Seung Hyuk Choi, Sang Hoon Lee, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Masahiro Yamawaki, Toshiya Muramatsu, Reiko Tsukahara, Yoshiaki Learning Objective: Indentify the mechanism of restenosis after Ito, Tsuyoshi Sakai, Hiroshi Ishimori, Keisuke Hirano, Masatsugu coronary bifurcation mechanism, based on the IVUS image analysis Nakano, Shinya Sasaki, Motoharu Araki, Akiyoshi Moriyama, Hideyuki Takimura, Yasunari Sakamoto, Ikki Komatsu, Saiseikai Yokohama city eastern hospital, Yokohama, Japan 2503-420 Predictors and Mechanism of Lesion Progression at the Side Branch Ostium after Main Vessel Stenting: Learning Objective: identify clinical outcome of single stent strategy Serial Intravascular Ultrasound Analysis with final kissing balloon technique using Paclitaxel- and Sirolimus- eluting stent, and predictor of angiographic restenosis at side Hahn Joo-Yong, Young Bin Song, Jin-Ho Choi, Seung-Hyuk Choi, branch ostium Sang Hoon Lee, Hyeon-Cheol Gwon, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea 2503-432 Bifurcation Angle and T-Stenting and Small Learning Objective: To identify predictors and mechanism of lesion Protrusion (TAP) Bifurcation Percutaneous Coronary progression at the side branch ostium after 1-stent technique Intervention Technique

Long Term Results For The Diverge Trial: 1 And 2 Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Seung-Hyuk Choi, Sang 2503-421 Hoon Lee, Hyeon-Cheol Gwon, Samsung Medical Center, Seoul, Year Clinical Outcomes For The Axxess Bioliums A9 South Korea Eluting Self Expanding Stent For The Treatment Of De Novo Bifurcation Lesions Learning Objective: know low-bifurcation angle was not associated with increased incidence of MACE and TLR in patients undergoing Alexandra J. Lansky, Stefan Verheye, John Ormiston, Christophe bifurcation PCI using TAP technique. Dubois, Ecaterina Cristea, Roxana Mehran, Brett Trauthen, Rachel Johnson, Cardiovascular Research Foundation, New York, CA, Devax, Irvine, CA Learning Objective: To underdstand outcomes and performance of a self expandinding stent in a bifurcation A200 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2503-433 NOBORI Bifurcation Study 2503-439 Long Term Safety and Prognosis of Ultra Long Sirolimus-Eluting Stent Implantation Gian Battista Danzi, Sr., Fina Mauri Ferre, Petr Kala, Marcus Wiemer, Farzin Fath-Ordoubadi, Rene Koning, Didier Carrie, William Wijns, Ren Kawaguchi, Hakuken Kan, Eiji Yamashita, Takuji Toyama, Hiroshi Javier Goicolea Ruigomez, Nick West, Antonio Serra, Zoran Perisic, Hoshizaki, Shigeru Oshima, Gunma Prefectural Cardiovascular Nikola Jagic, Vladimir Miloradovic, Ospedale Maggiore Policlinico, Center, Maebashi, Japan Milan, Italy Learning Objective: evaluate the long term safety and efficacy of Learning Objective: assess biodegradable polymer and Biolimus A9 sirolilus-eluting stent implantation for the ultra long lesion which is as a possible treatment option for bifurcation stenting one of the concerned issues because of that might has frequent stent thrombosis 2503-435 6-months outcomes of the Placlitaxel Eluting Balloon for the treatment of In-stent Restenosis and 2503-443 Drug-Eluting Stents for the Treatment of Chronic Small Vessel Disease: Insights from the Spanish Total Occlusion: A Comparison with Sirolimus, Multicenter Registry Paclitaxel, Zotarolimus, BiolimusA9, EPC Capture and Everolimus-Eluting Stent: Multicenter Registry beatriz vaquerizo, Antonio Serra, Faustino Miranda, Vanesa in Asia Martinez, Jose Antonio Gómez-Hospital, Angel Cequier, Andrés

i2 Summit Iñiguez, José Antonio Baz, Guillermo Bastos, Eduardo Fernández, Sunao Nakamura, Shotaro Nakamura, Hisao Ogawa, Jang-Ho Bae, Oriol Rodríguez, Josepa Mauri, Mario Sádaba, José Ramón Yeo Hans Cahyadi, Wasan Udayachalerm, Damras Tresukosol, Rumoroso, Asier Subinas, Rafael Gracía-Borbolla, Antonio Gómez, Sudaratana Tansuphaswadikul, New Tokyo Hospital, Chiba, Japan Jesús Oneto, Antonio Martínez, Francisco Bossa, Sara Rodríguez, (Interventional Cardiology) Raul Moreno, Alejandro Saez, Del Mar Hospital, Barcelone, Spain Learning Objective: Describe the clinical efficacy of SES, PES, ZES, BES, ECS and EES implantation in patients with chronic total occlusion Learning Objective: “describe” In some situations the use of BMS which is safe, low restenosis rate and low incidence of complication. or DES may be considered inappropriate or harmful because its association with a high risk of restenosis and/or stent thrombosis 2503-444 Four-Year Durability of Sirolimus-Eluting Stent in the use of this new paclit Patients with Chronic Total Occlusions Compared with Bare Metal Stent: Multicenter Registry in Asia 2503-436 Frequency and Predictors of Drug-Eluting Stent Use in Saphenous Vein Bypass Graft Sunao Nakamura, Hisao Ogawa, Jang-Ho Bae, Yeo Hans Percutaneous Coronary Interventions: A Report Cahyadi, Wasan Udayachalerm, Damras Tresukosol, Sudaratana from the American College of Cardiology - National Tansuphaswadikul, New Tokyo Hospital, Chiba, Japan Cardiovascular Data Registry Learning Objective: Describe the clinical efficacy and durability of SES implantation in patients with chronic total occlusion which Emmanouil S. Brilakis, Tracy Y. Wang, Sunil V. Rao, Subhash is safe, low restenosis rate and low incidence of complication Banerjee, David Dai, Chee T. Chin, Tina M. Harding, Matthew T. Roe, compared with BMS. VA North Texas Healthcare System and UT Southwestern Medical Center, Dallas, TX, Duke Clinical Reseach Institute, Durham, NC 2503-445 Recanalization Pattern of Porcine Coronary Chronic Learning Objective: identify factors associated with use of drug- Total Occlusions. eluting stents in saphenous vein graft lesions Paul Fefer, III, Beiping Qiang, Nigel Munce, Normand Robert, Kevan 2503-437 Drug-eluting Stents Versus Bare Metal Stents In J. Anderson, Xui Ling Qiang, Max Weisbrod, Graham A. Wright, Saphenous Vein Graft Lesions: A Meta-analysis Of Bradley H. Strauss, Sunnybrook Health Sciences Centre, Toronto, 22 Clinical Comparative Trials ON, Canada Learning Objective: Identify patterns of neovascularization in CTOs Feng Zhang, Lili Dong, Junbo Ge, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Serial Angiographic Follow-Up after Successful Shanghai, People’s Republic of China 2503-446 Implantation of Sirolimus-Eluting Stent and Learning Objective: show that DES is superior to BMS in Paclitaxel-Eluting Stent for Chronic Total Occlusions: reducing the incidences of all-cause death, TVR and MACE, with Multicenter Registry in Asia nonsignificant differences in terms of non-fatal myocardial infarction and stent thrombosis. Sunao Nakamura, Hisao Ogawa, Jang-Ho Bae, Yeo Hans Cahyadi, Wasan Udayachalerm, Damras Tresukosol, Sudaratana 2503-438 Long Term (5 Years) Outcomes in Patients with Tansuphaswadikul, New Tokyo Hosipital, Chiba, Japan Unprotected Left Main Coronary Artery Stenosis Learning Objective: Describe a different timing of late catch up Treated with Drug-Eluting Stent Implantation: a phenomenon after successful implantation of SES and PES in Single Center Experience. patients with chronic total occlusion. Valeria Magni, Alaide Chieffo, Alfonso Ielasi, Matteo Montorfano, Long-term Clinical Outcomes of Patients With Azeem Latib, Cosmo Godino, Mauro Carlino, Iassen Michev, Antonio 2503-447 Colombo, San Raffaele Hospital, Milan, Italy, EMO GVM Centro Sirolimus-Eluting Stent Fracture Cuore Columbus, Milan, Italy Ung Kim, Dong-Kie Kim, Sang-Hoon Seol, Tae-Hyun Yang, Dae- Learning Objective: long term follow up after percutaneous Kyeong Kim, Doo-Il Kim, Dong-Soo Kim, Inje University Busan Paik treatment of left main coronary artery lesions Hospital, Busan, South Korea Learning Objective: This study demonstrates long-term outcomes of patients with sirolimus-eluting stent fracture JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A201

2503-449 The Effects Of Combination Of Felodipine And 2503-456 Pediatric 64-channel Ct Angiography: Technical Ramipril On Regression And Compositional And Clinical Applications In 1548 Consecutive Changes Of Plaque In Patients With Hypertension Examinations And Angina With Mild To Moderate Degree Of Jeffrey Hellinger, Michael Poon, Monica Epelman, Stony Brook Coronary Stenosis University, Stony Brook, NY, The Childrens Hospital of Philadelphia, Young Joon Hong, Myung Ho Jeong, Yun Ha Choi, Eun Hye Ma, Philadelphia, PA Jum Suk Ko, Min Goo Lee, Keun Ho Park, Doo Sun Sim, Nam Sik Learning Objective: Understand Pediatric CTA technique and Yoon, Hyun Ju Youn, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, applications Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee

Kang, Heart Center of Chonnam National University Hospital, Clinical Efficacy and Long Term Outcomes of CT Cardiology) (Interventional Gwangju, South Korea 2503-457 Guided Percutaneus Coronary Intervention Learning Objective: to assess the efficacy of combination therapy of felodipine and ramipril Michael C.L. Lim, Catherine G. de Larrazabal, Levinia M. Devaraj, i2 Summit June Yang, Singapore Medical Specialists Centre, Singapore, Singapore 2503-450 Radiation Induced Lens Opacities In The Eyes Of Cath Lab Staff Learning Objective: understand the benefits of CT guided percutaneous coronary intervention Kui-Hian Sim, Madan Rehani, Norman Kleiman, Olivera Ciraj-Bjelac, Eliseo Vano, International Atomic Energy Agency, Vienna, Austria, Coronary Plaque Burden by Quantitative Coronary Sarawak General Hospital, Kuching, Malaysia 2503-458 Angiography Correlates with Plaque Burden by CT Learning Objective: Radiation Protection for Cardiologists Coronary Angiography and Intravascular Ultrasound

Anna M. Kalynych, Gustavo Vazquez, Dimitri Karmpaliotis, Zhen 2503-451 Clinical Determinants of Radiation Skin Dose in Adult Percutaneous Coronary Intervention Qian, Eric Krivitsky, Idean B. Marvasty, Sarah Rinehart, Szilard Voros, Piedmont Heart Institute, Atlanta, GA Kenneth A. Fetterly, Ryan J. Lennon, Malcolm R. Bell, David R. Learning Objective: Coorelation of 3D-CTA and IVUS is stronger than Holmes, Jr., Charanjit S. Rihal, Mayo Clinic, Rochester, MN QCA and IVUS Learning Objective: Identify the clinical determinants of radiation skin dose for adult percutaneous coronary intervention. 2503-459 Composition of Coronary Atherosclerotic Plaques in Diabetic and Non-diabetic Patients determined 2503-452 Role of ECHO Doppler in Detection of Radial by 64-row Multidetector Computed Tomographic Artery Anomalies Prior to Transradial Access for Angiography Interventions Jae-Sik Jang, Yong-Seop Kwon, Chang-Won Lee, June-Hyung Kim, Anand Gnanaraj, Suma M. Victor, Vijayakumar Subban, Rajendra Inje University Haeundae Paik Hospital, Busan, South Korea, Busan Deshmukh, Thomas George, Ezhilan Janakiraman, Ulhas St. Mary’s Hospital, Busan, South Korea Pandurangi, Latchumanadhas kalidoss, Mullasari Ajit sankaradoss, Learning Objective: identify high risk coronary atherosclerotic Institute of Cardiovascular diseases, Madras Medical Mission, plaques in high risk diabetic patients Chennai, India

Learning Objective: Identify the importance of preprocedural 2503-460 The Coronary Wall by OCT in Patients with Coronary verification of radial artery anomalies. Spasm

2503-453 Assessment of Common Femoral Angiograms Olivia Manfrini, Edoardo Verna, Jorge A. Salerno Uriarte, Antonio during Cardiac Procedures in the Morbidly Obese Bartorelli, Cesare Fiorentini, Raffaele Bugiardini, Univerity of Bologna, Bologna, Italy Douglas B. Bogart, Dan Sun, Mohammed Al-Amoodi, Lori Wayne, Learning Objective: understand that OCT does not recognize any Martha Bogart, University of Missouri-Kansas City, Kansas City, MO, typical structural feature for coronary segments having spasm Truman Medical Center, Kansas City, MO

Learning Objective: Utilize the common femoral angiogram to guide 2503-461 Long-term (>2 Years) Follow-up Results Of femoral artery access the the morbidly obese patient Sirolimus- And Paclitaxel-eluting Stent In Optical Coherence Tomography: Comparison To 9-months 2503-455 Characterization of Coronary Atherosclerotic Follow-up Results Plaques by Multislice Computed Tomography. Comparison With Optical Coherence Tomography Tae Hoon Kim, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Won Heum Shim, Seung Yun Cho, Ito Tsuyoshi, Mitsuyasu Terashima, Mariko Ehara, Hitoshi Matsuo, Severance Cardiovascular Hospital, Seoul, South Korea Masashi Kimura, Kenya Nasu, Maoto Habara, Nobuyoshi Tanaka, Yasushi Asakura, Yoshihisa Kinoshita, Etsuo Tsuchikane, Osamu Learning Objective: Our OCT data demonstrated that neointimal Kato, Takahiko Suzuki, Toyohashi Heart Center, Toyohashi, AL, Japan coverage 2 years after SES stent implantation is not sufficient. Learning Objective: evaluate A202 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2503-462 Differences Of Optical Coherence Tomographic 2503-491 New Index of Microvascular Resistance Reserve for Findings Between Excimer Laser And Cutting Evaluating Microvascular Dysfunction in Patients Balloon Angioplasty For In-Stent Restenosis Lesion With Diabetes Mellitus

Masami Nishino, Takeshi Masaki, Naoki Mori, Takahiro Yoshimura, Koichi Tamita, Atsuhi Yamamuro, Syuichiro Kaji, Minako Katayama, Daisuke Nakamura, Yasuharu Lee, Masahiko Hara, Shinpei Yutaka Furukawa, Nishinomiya Watanabe Cardiovascular Center, Nakatani, Masayuki Taniike, Nobuhiko Makino, Hiroyasu Kato, Nishinomiya, Japan, Kobe City Medical Center General Hospital, Yasuyuki Egami, Ryu Shutta, Hitoshi Yamaguchi, Jun Tanouchi, Kobe, Japan Yoshio Yamada, Division of Cardiology, Osaka Rosai Hospital, Sakai, Learning Objective: To evaluate microvascular dysfunction in Osaka, Japan patients with diabetes mellitus using by intracoronary Doppler and Learning Objective: learn detailed findings of neointimal condition pressure guide wire after excimer laser using optical coherence tomography. 2503-492 Coronary Artery Remodeling and Plaque 2503-463 A novel classification of neointimal characteristics Composition in Non Infarct Related Coronary after Drug Eluting-Stent Implantation: Optical Arteries in Patients Presenting with ST Segment Coherence Tomographic Analysis Elevation Myocardial Infarction: Where is the Necrotic Core? i2 Summit Nobuyoshi Tanaka, Mitsuyasu Terashima, Sudhir Rathore, Kenya Nasu, Masashi Kimura, Tatsuya Ito, Yoshihisa Kinoshita, Mariko Rasmus Egede, Lisette O. Jensen, Gary S. Mintz, Knud N. Hansen, Ehara, Etsuo Tsuchikane, Keiko Asakura, Yasushi Asakura, Osamu Knud E. Pedersen, Anders Junker, Henrik S. Hansen, Per Thayssen, Kato, Takahiko Suzuki, Toyohashi Heart Center, Toyohashi, Japan (Interventional Cardiology) Department of Cardiology, Odense University Hospital, Odense, Learning Objective: demonstrate a novel classification of neointimal Denmark, Cardiovascular Research Foundation, New York, NY characteristics after drug eluting-stent implantation Learning Objective: describe the minimum lumen area site and the maximum necrotic core sites in regard to the definition and 2503-464 Analysis of In-stent Restenosis Pattern by Optical location. Coherence Tomography: Inpact of Difference in Stent Type and Follow-up Period 2503-493 Does The Second Generation OCT Improve Safety And Feasibility In Clinical Practice? A Single Center Ippei Kosedo, Shingo Hosogi, Yuki Tsujimoto, Kentaro Shibayama, Experience Naoki Saito, Suguru Otsuru, Yoji Okamoto, Mana Kusunose, Masao Imai, Hiroshi Tasaka, Daiji Hasegawa, Yoshikazu Shigemoto, Seiji Takayuki Okamura, Nieves Gonzalo, Juan Luis Gutierrez Chico, Habara, Hiroyuki Tanaka, Takeshi Maruo, Akitoshi Hirono, Yoshiharu Patrick W. Serruys, Robert J. van Geuns, Willem J. van der Giessen, Nishibori, Yasushi Fuku, Naoki Oka, Harumi Katoh, Hiroyuki Jurgen M. Ligthart, Gijs van Soest, Guillermo J. Tearney, Brett E. Yamamoto, Satoki Fujii, Tsuyoshi Goto, Kazushige Kadota, Kazuaki Bouma, Evelyn Regar, Thoraxcenter, Erasmus MC, Rotterdam, The Mitsudo, Kurashiki Central Hospital, Kurashiki, Japan Netherlands, Massachusetts General Hospital, Boston, MA Learning Objective: identify the characteristics of ISR pattern by Learning Objective: appreciate the safety and feasibility of using the OCT new generation optical coherence tomography.

2503-489 The Axial Distribution Of Plaque Ruptures And A 2503-494 Reproducibility of In-vivo Coronary Fourier Domain Thin-cap Fibroatheroma Within The Culprit Lesion Optical Coherence Tomography In Acute Coronary Syndrome Patients: An Optical Coherence Tomography Study Takayuki Okamura, Nieves Gonzalo, Juan Luis Gutierrez Chico, Patrick W. Serruys, Nico Bruining, Robert J. van Geuns, Jurgen M. Hyoung-Mo Yang, So-Yeon Choi, Seung-Jea Tahk, Hong-Seok Lim, Ligthart, Gijs van Soest, Evelyn Regar, Thoraxcenter, Erasmus MC, Byoung-Joo Choi, Myeong-Ho Yoon, Jae-Hyun Moon, Jin-Sun Park, Rotterdam, The Netherlands Gyo-Seung Hwang, Joon-Han Shin, Ajou University Medical Center, Learning Objective: appreciate that optical coherence tomography Suwon, South Korea is a reliable tool for the in-vivo measurement of stent and lumen Learning Objective: to demonstrate the distribution of vulnerable dimensions. plaques in the culprit lesion of ACS patients in vivo. 2503-495 Evaluation of Side Branch Opening Using Three 2503-490 Favorable Neointimal Coverage in Everolimus- Dimensional Visualization of New Generation Eluting Stent at 9 Month after Stent Implantation: Optical Coherence Tomography after Bioabsorbable Comparison with Sirolimus-Eluting stent using Everolimus Eluting Stent Implantation Optical Coherence Tomography Takayuki Okamura, Yoshinobu Onuma, Juan Luis Gutierrez Chico, Hyun-Hee Choi, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Evelyn Regar, Patrick W. Serruys, Thoraxcenter, Erasmus MC, Myeong-Ki Hong, Yangsoo Jang, Won-Heum Sim, Seung-Yun Cho, Rotterdam, The Netherlands Severance Cardiovascular Hospital, Seoul, South Korea Learning Objective: evaluate side-branch jailed by BVS struts with Learning Objective: evaluate the pattern of neointimal coverage in 3-D FD-OCT reconstruction everolimus-eluting stent JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A203

2503-496 The Relationship between the Plaque Morphology 2503-502 A New Set of Intravascular Ultrasound-Derived of Culprit Lesions and Clinical Presentations of ACS Anatomical Criteria for Defining Functionally Patients: an Optical Coherence Tomography Study Significant Stenoses in Small Coronary Arteries Results from Intravascular ultrasound Diagnostic Yasushi Ino, Hironori Kitabata, Takashi Kubo, Atsushi Tanaka, Evaluation of Atherosclerosis in Singapore (IDEAS) Kenichi Komukai, Takashi Tanimoto, Kouhei Ishibashi, Tomizou Masuno, Shigeho Takarada, Aiko Shimokado, Akio Kuroi, Kumiko study. Hirata, Keizou Kimura, Masato Mizukoshi, Toshio Imanishi, Takashi Chi Hang Lee, Bee-Choo Tai, Chao-Yang Soon, Adrian F. Low, Kian- Akasaka, Wakayama Medical University, Wakayama, Japan Keong Poh, Tiong-Cheng Yeo, Gek-Hsiang Lim, James Yip, Abdul Learning Objective: The plaque morphology of culprit lesions may Omar Razakjr, Swee-Guan Teo, Huay-Cheem Tan, National University affect obstructive thrombus formationin ACS. We investigated the Heart Centre, Singapore, AL, Singapore, Alexandra Hospital, Cardiology) (Interventional relationship between the plaque morphology by OCT and clinical Singapore, AL, Singapore presentations. Learning Objective: Identify a new set of intravascular ultrasound-

derived anatomical criteria for defining functionally significant i2 Summit 2503-497 High-Risk Morphological Characteristics in Optical stenoses in small coronary arteries Coherence Tomography Study Are Correlated With Complex Angiographic Morphology 2503-503 Renal Dysfunction and Coronary Plaque Morphology by Intravascular Ultrasound: A Report from the Andreas Synetos, Konstantinos Toutouzas, Antonis Karanasos, Elefterios Tsiamis, Maria Drakopoulou, Maria Riga, John Diabetes Genome Project Karambelas, Costas Tsioufis, Christodoulos Stefanadis, 1st Joshua Stolker, Ahmad Tuffaha, Jason B. Lindsey, John A. House, Department of Cardiology, Hippokration Hospital, Athens, Greece Lindsey Seifert, Steven P. Marso, St Luke’s Mid America Heart Learning Objective: associate the angiographic lesion appearance Institute, Kansas City, MO with plaque morphology Learning Objective: Evaluate the relationship between renal function and morphologic atherosclerotic changes in the coronary arteries by 2503-498 Homogeneous Arterial Healing Between Culprit intravascular ultrasound and Non-Culprit Segments after Deployment of Zotarolimus-Eluting Stent in Patients with ST- 2503-504 Mechanism of Edge Restenosis of Sirolimus-Eluting elevation Myocardial Infarction: Sub-analysis Of The Stents: Serial Intravascular Ultrasound Analysis OCTAMI Trial. Eiji Ichimoto, Yoshio Kobayashi, Nakabumi Kuroda, Issei Komuro, Satoko Tahara, Hiram G. Bezerra, Giulio Guagliumi, Hiroyuki Kyono, Department of Cardiovascular Science and Medicine, Chiba Vasile Sirbu, Orazio Valsecchi, Alessandro Aprile, Motaz Baibars, University Graduate School of Medicine, Chiba, Japan Giuseppe Musumeci, Marco A. Costa, University Hospitals Case Learning Objective: evaluate that sirolimus-eluting stent edge Medical Center, Cleveland, OH, Division of Cardiology, Ospedali restenosis occurs due to the combination of negative vessel Riunti di Bergamo, Bergamo, Italy remodeling and progression of plaque in the segment closest to the Learning Objective: Evaluate vascular healing by OCT stent edge.

2503-500 Is Spotty Calcification Revealed By Gray Scale 2503-506 Relationship Among Serial Coronary Arterial Intravascular Ultrasound Really Vulnerable? A Remodeling, Stenosis Progression, and Plaque Virtual Histology Intravascular Ultrasound Study Composition: A VH-IVUS Tissue Characterization Analysis Hideo Amano, Kenji Wagatsuma, Mikihito Toda, Hideo Nii, Yasuto Uchida, Jyunichi Yamazaki, Division of interventional Cardiology, So-Yeon Choi, Akiko Maehara, Gary S. Mintz, Takashi Kubo, M. Cardiovascular Center, Toho University Omori Medical Center, Tokyo, Pauliina Margolis, Gregg W. Stone, Martin B. Leon, Columbia Japan University Medical Center and the Cardiovascular Research Foundation, New York, NY Learning Objective: Spotty calcification in gray scale IVUS has a higher NC/DC ratio in VH-IVUS compared to intermediate and Learning Objective: evaluate extensive calcification, and is believed to have a higher degree of vulnerability. 2503-507 Plaque Composition Change in Coronary Bifurcation Atherosclerosis after 1 year: a study with 2503-501 Intravascular Ultrasound Volumetric Analysis of intravascular ultrasound Virtual Histology Coronary Bifurcation Lesions: Changes in the Area and Volume of the Main Vessel Stent Following Eun Seok Shin, Hector M. Garcia-Garcia, Patrick W. Serruys, Ulsan Side-Branch and Final Kissing Balloon Inflations University Hospital, Ulsan, South Korea, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands Massoud A. Leesar, Mehmet Cilingiroglu, Imran Arif, Mohamed Effat, Learning Objective: Evaluate the change of plaque composition in Shahid Rahman, Tarek Helmy, University of Cincinnati, Cincinnati, bifurcation lesion after 1 year MI, Afghanistan Learning Objective: To evaluate impact of IVUS on the expansion of stent in the coronary bifurcation lesions A204 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2503-508 Target Lesion Thin-cap Fibroatheroma Detected By 2503-516 Evaluation Of Instent Neointimal Tissue Component Virtual Histology Intravascular Ultrasound And Long- Using Integrated Backscatter Intravascular term Prognosis In Patients With Angina Pectoris Ultrasound - Comparison Of Drug-eluting Stents And Bare-metal Stents - Hiroyuki Okura, Takahiro Kawamoto, Ryotaro Yamada, Yoshinori Miyamoto, Tetsuo Tsuchiya, Akihiro Hayashida, Yoji Neishi, Shinjo Sonoda, Yoshitaka Muraoka, Yuki Tsuda, Seiya Tanaka, Tomoichiro Kubo, Nobuya Matsushita, Takeshi Ozaki, Hiroyuki Masahiro Okazaki, Yutaka Otsuji, University of Occupational & Yamagishi, Iku Toda, Kiyoshi Yoshida, Kawasaki Medical School, Environmental Health, Kitakyushu, Japan Kurashiki, Japan, Bell Land General Hospital, Sakai, Japan Learning Objective: identify neointimal tissue characteristics of Learning Objective: demonstrate prognostic impact of target lesion drug-eluting stents TCFA 2503-517 Quantitative and Compositional Differences in 2503-509 The Utility of Routine Intra-vascular Ultrasound Coronary Atheroma in Patients With vs. Without during Percutaneous Coronary Intervention of Diabetes Mellitus (DM), Detected In Vivo Via Saphenous Vein Grafts. Intravascular Ultrasound-Virtual Histology (IVUS-VH) Asmir I. Syed, Gabriel Maluenda, Itsik Ben-Dor, Manuel A. Gonzalez, Prior to Percutaneous Coronary Intervention (PCI) i2 Summit Michael A. Gaglia, Cedric Delhaye, Loic Belle, Kohei Wakabayashi, Sandeep Nathan, Linda Lee, Falak Shah, Sandra A. Weiss, Nicholas Hanna, Sara D. Collins, Rebecca Torguson, Zhenyi Xue, Shashank Sinha, Adam Goldberg, John J. Lopez, University of Nelson Bernardo, William O. Suddath, Kenneth M. Kent, Lowell Chicago Medical Center, Chicago, IL, Loyola University Medical F. Satler, Augusto D. Pichard, Joseph Lindsay, Ron Waksman, (Interventional Cardiology) Center, Maywood, IL Washington Hospital Center, Washington, DC Learning Objective: Understand qualitative and quantitative Learning Objective: IVUS is not recommended in SVG PCI differences between diabetic and non-diabetic coronary artery disease 2503-510 Even After Percutaneous Coronary Intervention of Angiographically Significant Lesions, IVUS-defined 2503-518 The Impact of Pravastatin Pretreatment on High-Grade Stenoses Are Common. A Baseline IVUS Periprocedural Microcirculatory Damage in Patients Analysis from the PROSPECT Trial Undergoing Percutaneous Coronary Intervention

Akiko Maehara, Gary S. Mintz, Ecaterina Cristea, Alexandra J. Masashi Fukunaga, Kenichi Fujii, Daizo Kawasaki, Hirokuni Lansky, Roxana Mehran, George Dangas, Barry Templin, Wai-Fung Akahori, Katsumi Oka, Motomaru Masutani, Takeshi Tsujino, Cheong, John McPherson, Bernard de Bruyne, Naim Farhat, Steven Mitsumasa Ohyanagi, Tohru Masuyama, Hyogo College of Medicine, Marso, Jean Fajadet, Michael Foster, Patrick W. Serruys, Gregg W. Nishinomiya, Japan Stone, Cardiovascular Research Foundation and Columbia University Medical Center, New York City, NY Learning Objective: interpret the efficacy of statin administration before percutaneous coronary intervention Learning Objective: To undertstand the frequency secondary significant non-culprit lesions in patients undergoind primary PCI 2503-520 A Normal Relative Coronary Flow Reserve is Associated with a Lower Mortality in Patients With 2503-514 Target Lesion Thin-cap Fibroatheroma Detected By Stable Coronary Artery Disease. Virtual Histology Intravascular Ultrasound Affects Microvascular Injury During Percutaneous Coronary Martijn Meuwissen, Steven AJ Chamuleau, Karel T. Koch, Robbert Intervention In Patients With Angina Pectoris J. de Winter, Marije M. Vis, Jan Baan, Jr, Jan GP Tijssen, Jose PS Henriques, Jan J. Piek, Acadeic Medical Center, Amsterdam, The Ryotaro Yamada, Hiroyuki Okura, Teruyoshi Kume, Yoji Neishi, Netherlands Takahiro Kawamoto, Akihiro Hayashida, Tetsuo Tsuchiya, Ken Saito, Koichiro Imai, Kiyoshi Yoshida, Kawasaki Medical School, Kurashiki, Learning Objective: identify patients at risk Japan 2503-521 Coronary Blood Flow Assessment After Successful Learning Objective: investigate the relationship between TCFA Reperfusion for Acute Myocardial Infarction Predicts detected by VH-IVUS and change of IMR during PCI in patients with the Risk of In-Hospital and Long-Term Malignant angina pectoris. Arrhythmia 2503-515 Necrotic Core Distribution at the Coronary Kitae Kim, Atsushi Yamamuro, Satoshi Honda, Tomohiro Nishino, Bifurcation, and the Association Between Side Shunsuke Funakoshi, Noriyuki Kimura, Yoshimori An, Takeshi Kitai, Branch Bifurcation Angle and Vulnerability: A Virtual Atsushi Kobori, Natsuhiko Ehara, Makoto Kinoshita, Shuichiro Kaji, Histology Intravascular Ultrasound Study Tomoko Tani, Shigefumi Morioka, Toru Kita, Yutaka Furukawa, Kobe City Medical Center General Hospital, Kobe, AL, Japan Hideo Amano, Kenji Wagatsuma, Mikihito Toda, Hideo Nii, Yasuto Uchida, Jyunichi Yamazaki, Division of interventional Cardiology, Learning Objective: interpret the importance of microvascular Cardiovascular Center, Toho University Omori Medical Center, Tokyo, dysfunction assessed by the coronary flow velocity pattern Japan Learning Objective: Bifurcations showed high vulnerability, and large distribution of NC was revealed on the side branch side. The vulnerability of the main vessel increases with an decreasing angle of the side branch. JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A205

2503-522 Recanalization Within 90 Minutes of Symptom 2504-420 Comparison of Bivalirudin versus Heparin Onset Critically Determines Coronary Microvascular Plus Glycoprotein IIb/IIIa Inhibitors in Patients Integrity in Patients with Acute Myocardial Undergoing An Invasive Strategy: A Meta-Analysis of Infarction Achieving TIMI Grade 3 Flow Randomized Clinical Trials

Atsushi Yamamuro, Shuichiro Kaji, Koichi Tamita, Kite Kim, Jashdeep S. Dhoot, Michael S. Lee, Hsini Liao, Tae Yang, Jonathan Yoshimori An, Syunsuke Funakoshi, Noriyuki Kimura, Tomohiro Tobis, Gregg Fonarow, Ehtisham Mahmud, David Geffen School Nishino, Satoshi Honda, Takeshi Kitai, Natsuhiko Ehara, Atsushi of Medicine at University of California, Los Angeles (Division of Kobori, Makoto Kinoshita, Tomoko Tani, Shigefumi Morioka, Toru Cardiology), Los Angeles, CA Kita, Yutaka Furukawa, Kobe City Medical Center General Hospital, Learning Objective: Evaluate the efficacy and safety of bivalirudin Kobe, Japan, Nishinomiya Watanabe Cardiovascular Center, compared with heparin plus glycoprotein (GP) IIb/IIIa inhibitors in Cardiology) (Interventional Nishinomiya, Japan patients undergoing percutaneous coronary intervention. Learning Objective: Early recanalization within 90 mnutes critically determines coronary microvascular integrity in patients with AMI 2504-421 Bivalirudin vs. Unfractionated Heparin in Patients i2 Summit achieving TIMI grade 3 flow. Undergoing Stenting of Saphenous Vein Grafts. An Analysis From the EVENT Registry 2503-523 The Reduction In Microvascular Resistance Following PCI In The Adjacent Vessel Territory Is Not Radwane Kesserwane, Neal Kleiman, Michelle Keyes, Michael Related To Collateral Flow Index. Pencina, Ali Sonel, Faisal Latif, Mazen Abu-Fadel, David Cohen, Jorge F. Saucedo, Oklahoma University Health Science Center, Oklahoma Billal Patel, Linda Smith, George Hart, Michael Fisher, Royal City, OK Liverpool University Hospital, Liverpool, United Kingdom, Liverpool Learning Objective: The abstract will shed the light of the safety and Chest and Heart Hospital, Liverpool, United Kingdom effectiveness of bivalirudin in saphenous vein graft interventions. Learning Objective: Identify the role of collateral circulation on microvascular function in response to PCI. 2504-422 Bivalirudin versus Heparin plus Glycoprotein IIb/ IIIa Inhibitors in Patients Undergoing PCI for Acute Coronary Syndrome: a Meta-analysis 2504 PHARMACOTHERAPIES AND COMPLEX PATIENTS Luke Kim, S. Chiu Wong, Hasan Ahmad, Edward Wingfield, Robert Monday, March 15, 2010, 3:30 p.m. - 4:30 p.m. M. Minutello, Geoffrey Bergman, Issam Moussa, Dmitriy N. Feldman, Georgia World Congress Center, Hall B5 New York Presbyterian Hospital - Weill Cornell Medical College, New Presentation Hour: 3:30 p.m. - 4:30 p.m. York, NY CME/CE Hours: 1 Learning Objective: evaluate the efficacy of bivalirudin versus heparin plus GP IIb/IIIa inhibition in patients undergoing PCI for ACS 2504-418 Impact of Bivalirudin Use on Body Mass Index and Peri-Procedural Bleeding After Percutaneous 2504-429 Clinical Benefits Of Glycoprotein IIb/IIa Inhibitors Coronary Intervention In Patients With Acute ST-Elevation Myocardial Cedric Delhaye, Loic Belle, Kohei Wakabayashi, Gabriel Maluenda, Infarction Pretreated With Clopidogrel Before Itsik Ben-Dor, Manuel A. Gonzalez, Michael A. Gaglia, Nicholas N. Primary Percutaneous Coronary Intervention Hanna, Sara D. Collins, Asmir I. Syed, Rebecca Torguson, Zhenyi Doo Sun Sim, Youngkeun Ahn, Myung Ho Jeong, Young Jo Kim, Xue, William O. Suddath, Lowell F. Satler, Kenneth M. Kent, Joseph Sung Chull Chae, Taek Jong Hong, In Whan Seong, Jei Keon Chae, Lindsay, Augusto D. Pichard, Ron Waksman, Washington, DC Chong Jin Kim, Myeong Chan Cho, Ki Bae Seung, Seung Jung Park, Learning Objective: The risk of PCI-related bleeding has a similar Chonnam National University Hospital, Gwangju, South Korea relationship to BMI in pts treated with bivalirudin to those receiving Learning Objective: learn that the efficacy of glycoprotein IIb/IIIa heparin. inhibitors should be revisited in the era of high-dose clopdiogrel loading before primay percutaneous coronary intervention. 2504-419 Bivalirudin versus Heparin plus Glycoprotein IIb/ IIIa Inhibitors in Patients Without “Adequate” 2504-430 Risk Factors for Bleeding Complications in Patients Clopidogrel Pretreatment: a Meta-analysis with PCI with Adjunctive Therapy with Bivalirudin Luke Kim, S. Chiu Wong, Edward Wingfield, Hasan Ahmad, Robert in Clinical Practice. Results from the IMPROVER- M. Minutello, Geoffrey Bergman, Issam Moussa, Dmitriy N. Feldman, Registry. New York Presbyterian Hospital - Weill Cornell Medical College, New York, NY Uwe Zeymer, Steffen Schneider, Harald Darius, Dietrich Gulba, Herzzentrum Ludwigshafen, Ludwigshafen, Germany Learning Objective: to evaluate the efficacy of bivalirudin versus heparin plus glycoprotein IIb/IIIa inhibitors in patients without Learning Objective: The identify predictors for bleeding “adequate” clopidogrel pretreatment complications after PCI with bivalirudin A206 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2504-431 Sex and ACT Following Heparin Bolus During 2504-437 Effect of Proton Pump Inhibitors on Clinical Percutaneous Coronary Intervention Outcome in Patients treated with Clopidogrel: a Systematic Review and Meta-Analysis Claudia C. Serrano, Yoon K. Yan, Hyunseok Kang, Christopher Cianci, Brittany LeMonda, Mun K. Hong, David Coven, Angela Jolanta M. Siller-Matula, Bernd Jilma, Karsten Schrör, Guenter Palazzo, Robert Leber, Claude Simon, Amy Chorzempa, Jacqueline Christ, Kurt Huber, Medical University of Vienna, Vienna, Austria Tamis-Holland, St Luke’s Roosevelt Hospital, New York, NY, Mount Sinai Medical Center, New York, NY Learning Objective: identify whether concomitant use of proton pump inhibitors and clopidogrel has a negative impact on patients Learning Objective: determine whether there are sex related outcome. differences in response to a weight adjusted Heparin bolus given during PCI. 2504-438 The Utility of Clopidogrel Re-loading for Patients Presenting with Acute Coronary Syndrome Who Are 2504-432 Comparative Effectiveness of Bleeding Avoidance On Chronic Clopidogrel Therapy and Undergoing Therapies in PCI Patients: Analysis from the Percutaneous Coronary Intervention. National Cardiovascular Data Registry® Asmir I. Syed, Itsik Ben-Dor, Rebecca Torguson, Zhenyi Xue, Manuel Steven P. Marso, Amit Amin, John A. House, Kevin F. Kennedy, John A. Gonzalez, Gabriel Maluenda, Kohei Wakabayashi, Loic Belle,

i2 Summit A. Spertus, Sunil V. Rao, David J. Cohen, John C. Messenger, John Cedric Delhaye, Michael A. Gaglia, Sara D. Collins, Nicholas Hanna, S. Rumsfeld, Mid America Heart Institute, Kansas City, MO, Duke Nelson Bernardo, Kenneth M. Kent, William O. Suddath, Lowell Clinical Research Institute, Durham, NC F. Satler, Augusto D. Pichard, Joseph Lindsay, Ron Waksman,

(Interventional Cardiology) Learning Objective: Describe use of bivalirudin and vascular closure Washington Hospital Center, Washington, DC devices by risk of bleeding Learning Objective: Clopidogrel reloading does not improve in- hospital outcomes 2504-433 Factor IXa Inhibition with REG1 Provides Rapid Onset, Stable and Actively Controlled 2504-439 The Effect Of Clopidogrel Low-responsiveness Anticoagulation during PCI Assessed By Verifynow P2y12 Assay On Thrombotic Events After Implantation Of Drug-eluting Stent Mauricio G. Cohen, Drew A. Purdy, Joseph S. Rossi, Liliana R. Grinfeld, Shelley K. Myles, Laura H. Aberle, Adam B. Greenbaum, Joong Kyung Sung, Young Jin Yoon, Nam Seok Lee, Jun Won Lee, Edward Fry, Mark Y. Chan, Steven Zelenkofske, John H. Alexander, Jang-Young Kim, Seung Hwan Lee, Junghan Yoon, Kyung-Hoon Choe, Robert A. Harrington, Christopher P. Rusconi, Richard C. Becker, Wonju Christian Hospital, Wonju, South Korea University of Miami Miller School of Medicine, Miami, FL, Duke Clinical Research Institute, Durham, NC Learning Objective: Identify the relationship between stent thrombosis and clopidogrel resistance Learning Objective: Understand the role of aptamers as anticoagulants 2504-443 Correlation Between the VerifyNow P2Y12 Assay and Light Transmittance Aggregometry To Measure 2504-435 High-Dose Clopidogrel Loading Is Safe And Effective Platelet P2Y12 Receptor Inhibition in Patients on In Patients With ST-Elevation Myocardial Infarction Clopidogrel Therapy Undergoing Primary Percutaneous Coronary Intervention Masafumi Ueno, Jose Luis Ferreiro, Kodlipet Dharmashankar, Piera Capranzano, Davide Capodanno, Andrew Darlington, Desai Bhaloo, Doo Sun Sim, Myung Ho Jeong, Youngkeun Ahn, Young Jo Kim, Ronald Charlton, Lyndon Box, Martin Zenni, Luis Guzman, Theodore Sung Chull Chae, Taek Jong Hong, In Whan Seong, Jei Keon Chae, Bass, Dominick J. Angiolillo, University of Florida college of Medicine Chong Jin Kim, Myeong Chan Cho, Ki Bae Seung, Seung Jung Park, Jacksonville, Jacksonville, FL Chonnam National University Hospital, Gwangju, South Korea Learning Objective: There is a strong correlation between VerifyNow Learning Objective: feel the need to revisit the efficacy and safety of P2Y12 and LTA parameters, which is best with aggregation values high-dose clopidogrel loading even in patients with acute myocardial obtained following addition of PGE1 to ADP stimuli. infarction undergoing primary percutaneous coronary intervention. 2504-444 Platelet Reactivity Testing Following Coronary 2504-436 Can Clopidogrel Loading (600mg) Be Administered Percutaneous Intervention Is Independent Of The <2 Hours Pre-PCI in Patients Presenting with Acute Initial Clinical Presentation Coronary Syndromes? Firas Zahr, Rosalyn Rapsinski, Roy Semaan, Oscar C. Marroquin, Dmitriy N. Feldman, Luke K. Kim, Robert M. Minutello, Geoffrey Suresh Mulukulta, Conrad Smith, Ashley Lee, Sun Scolieri, Joon S. Bergman, Issam Moussa, S. Chiu Wong, New York Presbyterian Lee, John T. Schindler, William D. Anderson, Catalin Toma, UPMC, Hospital, Weill Cornell Medical College, New York, NY Pittsburgh, PA, Firas Zahr, pittsburgh, PA Learning Objective: demonstrate whether clopidogrel loading Learning Objective: Demonstrate that platelet reactivity testing after (600mg) can be administered <2 hours pre-PCI in patients PCI is not effected by the clinical presentation presenting with acute coronary syndromes JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A207

2504-445 WITHDRAWN 2504-451 The sPLA2 Inhibition to Decrease Enzyme Release after Percutaneous Coronary Intervention (SPIDER- Predictive Value Of Various Platelet Function Tests 2504-446 PCI) Trial. On St-segment Resolution And Clinical Outcome In STEMI Patients Randomized To Either Dual Or Triple Vladimir Dzavik, Warren J. Cantor, Christopher B. Overgaard, Kevin Antiplatelet Therapy: The Ontime2 Platelet Function E. Thorpe, Shahar Lavi, Julie Lan, Eric Horlick, John R. Ross, Paul Substudy Daly, Alan Barolet, Douglas Ing, Sylvain Plante, Kim Robbins, Lorne Goldman, Rudiger von Harsdorf, Deborah Atchison, Leonard Heleen J. Bouman, Jochem W. van Werkum, Jaap J. Smit, Nicoline Schwartz, Peter H. Seidelin, Peter Munk Cardiac Centre, University J. Breet, Sonja Postma, Ton Heestermans, Jurriën M. ten Berg, Health Network, Toronto, ON, Canada, Southlake Regional Health Robbert Slingerland, Christian M. Hackeng, Christian Hamm, Arnoud Centre, Newmarket, ON, Canada van ‘t Hof, Ongoing in Tirofiban in Myocardial Infarction Evaluation Cardiology) (Interventional (ON-TIME) trial investigators, St. Antonius Hospital, Nieuwegein, The Learning Objective: understand the possible role of secretory Netherlands, Isala Klinieken, Zwolle, The Netherlands phospholipase A2 in limiting myocardial injury associated with PCI. i2 Summit Learning Objective: demonstrate that platelet function testing using 2504-452 Impact of IRS-1 Genotypes on Platelet Reactivity the PFA-100 COL/EPI cartridge is able to identify patients who are and Cardiovascular Outcomes in Type 2 Diabetes at higher risk for thrombo-ischemic events Mellitus Patients with Coronary Artery Disease 2504-447 Distribution Of Post-treatment Platelet Reactivity Dominick Angiolillo, Esther Bernardo, Martina Zanoni, Piera Assessed By Two Kinds Of Point-of-care Platelet Capranzano, Giovanni Malerba, Elisabetta Trabetti, Manel Sabate’, Function Analysis In Korean Patients Who Pilar-Jimenez Quevedo, Paola Prandini, Davide Capodanno, Underwent Drug-eluting Stent Implanation : A Single Jose’ Luis Ferreiro, Theodore Bass, Pier Franco Pignatti, Antonio Center, Pilot Study Fernandez-Ortiz, Carlos Macaya, University of Florida College of Medicine, Jacksonville, FL Myung-Ki Seo, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi, Jung-Won Learning Objective: demonstrate Suh, Seoul National University Hospital, Seoul, South Korea, Seoul National University Bundang Hospital, Seungnam, South Korea 2504-453 Association of CYP2C19*2 to Altered Clopidogrel Learning Objective: recognized that verifynow and multiplate assay Reactivity as Measured by a Point-of-Care Analysis are needed to evaluate further study. Derek Yiu Fai So, Irena Szymanska, Alex Stewart, Michel Le May, 2504-449 High Levels of Asymmetric Dimethyl-Arginine Marino Labinaz, Sandro Goncalves, Olivia Assogba, Chris Glover, (ADMA) Increase Residual Platelet Reactivity After Sonny Dandona, Robert Roberts, University of Ottawa Heart Clopidogrel Administration in Patients Undergoing Institute, Ottawa, ON, Canada Elective PCI Learning Objective: evaluate the possible utility of point of care clopidogrel response testing in identifying patients with the Annunziata Nusca, Giacomo Di Giovanni, Laura Gatto, Giuseppe CYP2C19*2 allele Patti, Andrea D’Ambrosio, Rocco Contuzzi, Germano Di Sciascio, Campus Bio-Medico University, Rome, Italy 2504-455 Comparison Of High-dose Bolus Tirofiban Versus Learning Objective: to demonstrate a correlation between high Abciximab As Adjunctive Therapy For Primary serum ADMA levels and residual platelet reactivity after clopidogrel Percutaneous Coronary Intervention In Patients administration With ST-elevation Myocardial Infarction: A Meta- analysis Of Randomized Trials 2504-450 Inter-assay Agreement To Define Inadequate Clopidogrel Response Lili Dong, Feng Zhang, Xianhong Shu, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Kodlipet C. Dharmashankar, Jose-Luis Ferreiro, Masafumi Ueno, Shanghai, People’s Republic of China Andrew Darlington, Davide Capodanno, Bhaloo Desai, Ronald K. Charlton, Luis A. Guzman, Theodore A. Bass, Dominick J. Angiolillo, Learning Objective: demonstrate that HDB tirofiban is as effective Division of Cardiology, Department of Medicine, University of Florida, as abciximab in the setting of PPCI for STEMI without an increase in Jacksonville, Jacksonville, FL bleeding risk.

Learning Objective: Platelet assays 2504-456 Low Dose Versus High Dose Aspirin After Coronary Stenting

Kishore J. Harjai, Chetan Shenoy, Pam Orshaw, Judy Boura, Guthrie Health System, Sayre, PA Learning Objective: Evaluate the efficacy of low-dose aspirin after PCI A208 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

Cilostazol Therapy Achieves Greater P2Y Inhibitory Does Oral Beta-Blocker Therapy Improve Long-term 2504-457 12 2504-462 Effects Compared To High Clopidogrel Maintenance Clinical Outcomes of ST-elevation Acute Myocardial Dosing In Suboptimal Clopidogrel Responders With Infarction After Primary Angioplasty? Diabetes Mellitus Neiko Ozasa, Kazuaki Mitsudo, Takeshi Morimoto, Hou Heigen, Jose Luis Ferreiro Gutierrez, Piera Capranzano, Masafumi Ueno, Toshihiro Tamura, Satoshi Shizuta, Takeshi Kimura, j-Cypher Registry Davide Capodanno, Kodlipet Dharmashankar, Andrew Darlington, Investigators, Graduate School of Medicine, Kyoto University, Kyoto, Bhaloo Desai, Ronald K. Charlton, Lyndon C. Box, Martin M. Zenni, Japan, Kurashiki Central Hospital, Kurashiki, Japan Luis A. Guzman, MD, Theodore A. Bass, Dominick J. Angiolillo, Learning Objective: evaluate optimal medication for acute University of Florida College of Medicine - Jacksonville, Jacksonville, myocardial infardtion after primary percutaneous coronary FL intervention. Learning Objective: Understand treatment options in T2DM patients with suboptimal response to standard clopidogrel dosing 2504-463 Efficacy of Statins in Patients After Percutaneous Coronary Interventions: Relation with Baseline CRP 2504-458 Initial Loading Therapy of Cilostazol Improved Values Antiplatelet Responsiveness in Patient with Percutaneous Coronary Intervention Carla Auguadro, Filippo Scalise, Emilia D’Elia, Valentina Casali,

i2 Summit Mariella Manfredi, Giuseppe Specchia, Dpt of Cardiology, Policlinico Moo Hyun Kim, Long H. Yu, Jung H. Kim, Sun Y. Park, Tae H. Park, of Monza, Monza, Italy Kwang S. Cha, Young D. Kim, Jin Y. Han, Dept. of Cardiology, Dong-A Learning Objective: identify post-PCI pts at high risk of cardiac

(Interventional Cardiology) Univ. Hospital, Busan, South Korea events in FU in whom the addition of statins may be useful in order Learning Objective: Demonstrate the role of loading effects of to reduce the risk cilostzol 2504-464 Effect Of Statins Pretreatment On Periprocedural 2504-459 The Efficacy And Safety of Triple Antiplatelet Myocardial Infarction In Patients Undergoing Therapy After Percutaneous Coronary Intervention Percutaneous Coronary Intervention: Insights From (PCI) in j-Cypher Registry. Randomized Clinical Trials

Tetsushi Nakao, Takeshi Kimura, Takeshi Morimoto, Satoshi Feng Zhang, Lili Dong, Junbo Ge, Shanghai Institute of Shizuta, Toshihiro Tamura, Takahiro Doi, Kazuaki Mitsudo, on behalf Cardiovascular Diseases, Zhongshan Hospital, Fudan University, of the j-Cypher Registry Investigators, Kyoto University Hospital, Shanghai, People’s Republic of China Department of Cardiovascular Medicine, Kyoto, Japan Learning Objective: demonstrate the beneficial effects of statins Learning Objective: We identify that patients received triple pretreatment on preventing periprocedural myocardial infarction in antiplatelet therapy after percutaneous coronary intervention had patients undergoing percutaneous coronary intervention. more comorbidities in j-Cypher Registry, which represent Japanese real clinical practice. 2504-466 Supralimus™ Bioabsorbable-Polymer Sirolimus- Eluting Stent Technology in Patients with Acute 2504-460 Early and Late Discontinuation of Oral Antiplatelet Coronary Syndrome: Two-Year Results of the Therapy after DES Implantation: Prevalence, Prospective, Multicenter, E-SERIES Registry. Predictors, and Long-term Prognosis Jose de Ribamar Costa, Jr., Alexandre Abizaid, Bruno Machado, Roberta Rossini, Corrado Lettieri, Giuseppe Biondi Zoccai, Giuseppe Maurício Prudente, Pritesh Parikh, George Ximenes, Edmur Musumeci, Tamar Nijaradze, Michele Romano, Nicola Cicorella, Araújo, Álvaro Matheus, Ricardo Costa, Fausto Feres, Andréa Nikoloz Lortkipanidze, Antonio Izzo, Vasile Sirbu, Antonello Gavazzi, Abizaid, Expedito Ribeiro, on behalf of E-SERIES investigators, Dominick J. Angiolillo, Ospedali Riuniti di Bergamo, Bergamo, Italy, Cardiovascular Research Center, São Paulo, Brazil University of Florida-Shands Jacksonville, Jacksonville, FL Learning Objective: Determine the long-term efficacy and safety of Learning Objective: identify the predictors of oral antiplatelet the Supralimus sirolimus-eluting stent with biodegradable polymer therapy discontinuation and to evaluate its effects on long-term for the treatment of patients with acute coronary syndromes prognosis 2504-467 Mid-Term Clinical Outcome of CATANIA™ Coronary 2504-461 Efficacy of CLotinab in Acute myocardial Stent System With Nanothin Polyzene®-F in a Real infarction Trial - ST Elevation Myocardial Infarction World Unselected Population: Preliminary Results (ECLAT -STEMI) Alessio La Manna, Alessandra Sanfilippo, Sergio Monaco, Maria Jung-Sun Kim, Sang Min Park, Young-Guk Ko, Donghoon Choi, Elena Di Salvo, Irene Cascone, Daniele Giacoppo, Piera Capranzano, Myeong-Ki Hong, In Whah Sung, Byung Ok Kim, Hyeon-cheol Kwon, Davide Capodanno, Corrado Tamburino, Division of Cardiology - Bum Kee Hong, Seung-Jae Tahk, Seong-Wook Park, Myung-Ho Jeong, Ferrarotto Hospital, Catania, Italy Chong Jin Kim, Junghan Yoon, Jin Won Kim, Byoung-Kuk Kim, Doo Il Kim, Jong-Sun Park, Sang Gon Lee, Jae Hun Jung, Byoung Eun Park, Learning Objective: Understand the clinical value of the Myeong Gon Kim, Yangsoo Jang, Division of Cardiology, Severance polyphosphazene coated coronary stent in a real world population Cardiovascular Hospital, Yonsei University, Seoul, South Korea Learning Objective: administration of Gp IIb/IIIa receptor inhibitor in the setting of 600 mg clopidogrel loading might be recommended for only needed patients during the PCI not all patients with STEMI. JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A209

2504-489 Short- and Long-term Clinical Outcomes in Patients 2504-494 SPIRIT V Registry: One Year Follow-up of Complex Undergoing Rescue Percutaneous Coronary Lesion and Patient Sub-Groups Intervention Compared with Primary Percutaneous Upendra Kaul, Escorts Heart Institute & Research Centre, New Coronary Intervention in ST-Elevation Myocardial Delhi, ID, India, Fortis Flt Lt Rajan Dhall Hospital, New Delhi, India Infarction Learning Objective: Demonstrate the safety and efficacy of the William Chan, David J. Clark, Andrew E. Ajani, Nick Andrianopoulos, everolimus drug eluting stent in complex lesions in real world scenarios Angela L. Brennan, Christopher M. Reid, Thomas Yip, James A. Shaw, Anthony M. Dart, Stephen J. Duffy, The Alfred Hospital, 2504-495 Clinical Outcomes in Different Ethnic Groups Melbourne, Australia Undergoing Percutaneous Coronary Intervention Learning Objective: compare the clinical outcomes of rescue Cardiology) (Interventional versus primary percutaneous coronary intervention in ST-Elevation Domingo Tagal Addatu, Jr., Joshua P. Loh, Li-Ling Tan, Liang Shen, Myocardial Infarction Adrian F. Low, Chi-Hang Lee, Swee Gan Teo, Huay Cheem Tan, National University Heart Center, Singapore, Singapore i2 Summit 2504-490 Physiogenomics of Thiazolidinedione Efficacy and Learning Objective: Demonstrate significant ethnic differences in Safety clinical outcomes following PCI in our multiethnic population

Richard L. Seip, James Bernene, Steven Hanks, Andreas 2504-496 What is the Real Incidence of Definite Stent Windemuth, Detlef Wencker, Mohan Kocherla, Theodore R. Holford, Thrombosis After Bare Metal Stent Implantation in Gualberto Ruaño, Genomas, Inc., Hartford, CT, The Hospital of the Real World Clinical Practice? Central Connecticut, New Britain, CT Learning Objective: identify gene variants relevant to statin and Marcelo Nakashima De Melo, Sr., Ricardo A Costa, J. Ribamar thiazolidinedione side effects Costa, Jr, Fausto Feres, Alexandre Abizaid, Marcos Ortega, Erwin Telles, Rodolfo Staico, Luiz A. Mattos, Galo Maldonado, Luiz F. Correlation of Specific Morphological Characteristics Tanajura, Carlos Collet, Amanda Sousa, J. Eduardo Sousa, Instituto 2504-491 Dante Pazzanese de Cardiologia, Sao Paulo, NY, Brazil of the Culprit Lesion With the Efficacy of Thrombolysis. An Optical Coherence Tomography Learning Objective: Investigate the incidence and correlates of stent Study thrombosis following bare metal stent implantation in the real-world clinical practice Konstantinos Toutouzas, Antonis Karanasos, Elefterios Tsiamis, Maria Riga, Andreas Synetos, Maria Drakopoulou, Costas Tsioufis, 2504-497 Predictors Of Mortality And Long-term Outcomes Elli Stefanadi, Dimitrios Tousoulis, Christodoulos Stefanadis, 1st Of Octogenarians Undergoing Transradial Department of Cardiology, Hippokration Hospital, Athens, Greece Percutaneous Coronary Intervention Learning Objective: describe the plaque morphological characteristics associated with flow restoration after thrombolytic Jean-Pierre Dery, Helena Tizon, Cindy Boulanger-Gobeil, Julie therapy administration Plaisance, Gerald Barbeau, Josep Rodés-Cabau, Stephane Rinfret, Eric Larose, Bernard Noël, Can M. Nguyen, Onil Gleeton, Guy Proulx, Louis Roy, Robert Delarochellière, Olivier F. Bertrand, Institut Long-term Prognosis in Patients with Coronary 2504-492 universitaire de cardiologie et de pneumologie de Quebec, Quebec Artery Disease Following Percutaneous Coronary City, QC, Canada Intervention Strictly Reducing Low Density Lipoprotein (LDL) Cholesterol with Statin -- Learning Objective: determine predictors of mortality in Importance of Patients with Low LDL at Baseline -- octogenarians undergoing PCI

Shigemitsu Tanaka, Yoshihiro Morino, Nobuhiko Ogata, Takashi 2504-498 Coronary Angiographic Findings and Results Matsukage, Naoki Masuda, Gaku Nakazawa, Toshiharu Fujii, Seiji of Percutaneous Coronary Intervention (PCI) in Tamiya, Daiki Itou, Makiyoshi Shima, Eri Toda, Yoshinari Kamiyama, Nonagenarians: A Single Tertiary Care Center Takayuki Iida, Takashi Ijichi, Teruhisa Tanabe, Yuji Ikari, Department Experience of Cardiology, Tokai University School of Medicine, Isehara, Japan Ashok K. Kondur, Hari Pawan, Ramanjit Kaur, Praveen Guntipalli, Luis Learning Objective: statin Afonso, Theodore Schreiber, Harper University Hospital, Detroit, MI

2504-493 Longest Available (up To Seven Years) Experience Learning Objective: PCI in nonagenarians confers a mortality benefit With Drug-eluting Stents For Non-selected Complex over medical management. Patients: Assessing The Independent Predictors Of Negative Events In The Desire Registry 2504-500 Hypoglycemia is Associated With an Increased Incidence of Peri-Procedural Myocardial Damage Jose de Ribamar Costa, Jr., Amanda Sousa, Adriana Moreira, in non-Diabetic Patients Undergoing Coronary Ricardo Costa, Manuel Cano, Galo Maldonado, Cantídio Campos Angioplasty nNeto, Mariana Carballo, J Eduardo Sousa, Hospital do Coração, São Paulo, Brazil Annunziata Nusca, Francesco Marino, Giuseppe Patti, Fabio Mangiacapra, Laura Gatto, Andrea D’Ambrosio, Rosetta Melfi, Marco Learning Objective: Determine the very long term results (up to Miglionico, Germano Di Sciascio, Campus Bio-Medico University, seven years) of drug-eluting stents for the treatment of complex, Rome, Italy unselected patients Learning Objective: to demonstrate that a hypoglycemic status at the time of PCI is associated with increased incidence of peri- procedural myocardial damage A210 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2504-501 Three-Year Clinical Outcomes with Sirolimus-Eluting 2504-507 Contrast Induced Nephropathy Post Percutaneous Stents for Diabetic Patients from j-Cypher registry Coronary Intervention: What is the Right Definition?

Tomohisa Tada, Toshihiro Tamura, Kazuaki Mitsudo, Takeshi Refat Jabara, Radhika Gadesam, Lakshmana Pendyala, Nicolas Kimura, Takeshi Morimoto, Atsushi Kawamura, Takahito Sone, Chronos, Jack Chen, Steven Manoukian, Hadassah-Hebrew Hideo Nishikawa, Akira Miura, Yukio Kazatani, Tomohiro Kawasaki, University Medical Center, Jerusalem, Israel, Saint Joseph’s Masanori Nomura, j-Cypher Registry investigators, Kyoto University Hospital, Atlanta, GA Hospital, Kyoto, Japan Learning Objective: Learn about the practical impact of the Learning Objective: evaluate the use of Silorimus-Eluting-Stent in definition utilized on the rate of CIN post PCI diabetic patients. 2504-508 The Effect of Drug-Eluting Stents on Clinical and 2504-502 Long-Term Mortality in Insulin Dependent Versus Angiographic Outcomes in Renal Failure Patients Non-Insulin Dependent Diabetic ST Elevation with Dialysis: Multicenter Registry in Asia Myocardial Infarction Patients after Primary Percutaneous Coronary Intervention Sunao Nakamura, Hisao Ogawa, Jang-Ho Bae, Yeo Hans Cahyadi, Wasan Udayachalerm, Damras Tresukosol, Sudaratana Loes P. Hoebers, Bimmer E. Claessen, Karel T. Koch, Marije M. Vis, Tansuphaswadikul, New Tokyo Hospital, Chiba, Japan

i2 Summit Jan Baan, jr, Jan G. Tijssen, Robbert J. de Winter, Jan J. Piek, Jose Learning Objective: Describe the clinical efficacy of SES, PES, ZES, P. Henriques, Academic Medical Center University of Amsterdam, BES and EES implantation in patients with chronic renal failure on Amsterdam, The Netherlands hemodialysis which is safe, low restenosis rate and low incidence

(Interventional Cardiology) Learning Objective: describe the impact of insulin dependent of complication. diabetes mellitus on the clinical outcome of STEMI patients after primary percutaneous intervention. 2504-509 Thrombotic Profile Analysis Using Thromboelastography In End Stage Renal Disease 2504-503 A Randomized Comparison of the Endeavor Drug Patients Undergoing Hemodialysis (ABT-578) Eluting Stent versus TAXUS Paclitaxel- Eluting Stent in Diabetic Patients: Three-Year Jose Luis Ferreiro Gutierrez, Andrew Darlington, Davide Capodanno, Masafumi Ueno, Piera Capranzano, Bhaloo Desai, Kodlipet Outcomes from ENDEAVOR IV Dharmashankar, Yoshie Suzuki, Stanley Nahman, Theodore A. Bass, Ajay Kirtane, Rikesh Patel, Charles O’Shaunessy, Brent McLaurin, Dominick J. Angiolillo, University of Florida College of Medicine - David E. Kandzari, Martin B. Leon, Columbia Medical Center and the Jacksonville, Jacksonville, FL Cardiovascular Research Foundation, New York, NY Learning Objective: Understand thrombotic profiles in hemodialysis Learning Objective: Evaluate the comparison of the Endeavor Drug patients Eluting Stent versus TAXUS Paclitaxel-Eluting Stent in Diabetic Patients 2504-510 Higher Mortality Rates After Percutaneous Coronary Intervention in Female Patients on Hemodialysis Long-Term Clinical Outcomes of Drug-Eluting Stents 2504-504 Luis Gruberg, Puja B. Parikh, Allen Jeremias, Srihari S. Naidu, in Diabetic Patients with Small Vessel Compared to Richard A. Shlofmitz, Sorin J. Brenner, Thomas Pappas, Kevin P. Larger vessel - Up to 7 Years Clinical Follow-up. Marzo, David L. Brown, Stony Brook University, Stony Brook, NY, Walid Hassan, Manzoor Memon, Adel Osman, Hani Al Sergani, Winthrop University Hospital, Mineola, NY Mohamed Mustafa, zulfiqar Ali, Suliman Kharabsheh, Nathem Learning Objective: Assess the impact of hemodialysis on female Akhras, Mohamed Shoukri, Aly Al Sanei, Charles Canver, King Faisal patients undergoing PCI Specialist hospital & Research Center, Riyadh, AE, Learning Objective: Evaluate the long term outcomes of DES in 2504-514 Efficacy of Spot Stenting with Sirolimus-Eluting diabetics with small vessel disease Stents in Diffuse Lesions of Dialysis Patients

Tatsuya Ito, Masashi Kimura, Hiroshi Fujita, Mitsuyasu Terashima, Validation of a Risk Score to Predict Contrast- 2504-506 Yoshihisa Kinoshita, Mariko Ehara, Nobuyoshi Tanaka, Kenya Nasu, Induced Acute Kidney Injury after Percutaneous Yasushi Asakura, Osamu Katoh, Takahiko Suzuki, Toyohashi Heart Coronary Intervention in Patients with ACS: Results Center, Toyohashi, Japan From the ACUITY Trial Learning Objective: demonstrate the favorable stenting strategy for Adriano M. Caixeta, Eugenia Nikolsky, Selene Leon, Martin Fahy, dialysis patients to reduce the restenosis rate. Ecaterina Cristea, Gregg W. Stone, Alexandra J. Lansky, and Roxana Mehran, Columbia University Medical Center and The Cardiovascular Research Foundation, New York, NY Learning Objective: To assess external validity of the proposed CIN risk score model using independent dataset JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A211

2504-515 Combined Impact of Chronic Kidney Disease and 2504-522 Randomized Clinical Trial To Compare The Anemia on Long-Term Clinical Outcomes After Nephrotoxic Effects Of Iso-osmolar Vs. Low-osmolar Percutaneous Coronary Intervention in the Drug- Contrast Medium In Diabetic Patients With Reduced Eluting Stent Era Renal Function

Yudai Yano, Yoshikazu Hiasa, Takahashi Tatefumi, Hirotoshi Chen, Tobias Koppara, Rainer Wessely, Adnan Kastrati, Christian Bradaric, Shin-ichiro Miyazaki, Riyo Ogura, Hitoshi Miyajima, Ken-ichiro Yuba, Stefanie Schulz, Marc Vorpahl, Siegmund Braun, Julinda Mehilli, Keitaro Mahara, Shinobu Hosokawa, Kouichi Kishi, Ryuuji Ohtani, Albert Schömig, Deutsches Herzzentrum München, Munich, Tokushima Red Cross Hospital, Komatsushima, Japan Germany, Klinikum rechts der Isar, Munich, Germany Learning Objective: demonstrate the long-term MACCE rate after PCI Learning Objective: assess the risk of contrast induced nephropathy is synergistically increased in patients treated with SES when CKD in diabetic patients. Cardiology) (Interventional is in association with anemia. 2504-523 Impact of Contrast-Induced Nephropathy in Three 2504-516 Sirolimus Eluting- vs. Paclitaxel Eluting Stent in Different Definitions on Long-Term Mortality After i2 Summit Patients With ST-Segment Elevation Myocardial Percutaneous Coronary Intervention in Patients Infarction and Renal Insufficiency Undergoing With and Without Chronic Kidney Disease: Insights Primary Angioplasty From CREDO-Kyoto Registry

Sang-Ho Jo, Young-Jin Choi, Hyun-Sook Kim, Sung-Ae Kim, Chong- Mitsuru Abe, Ryoji Taniguchi, Natsuhiko Ehara, Masaharu Akao, Yun Rhim, Kyu Rok Han, Hallym University Sacred Heart Hospital, Yutaka Furukawa, Takeshi Morimoto, Toru Kita, Takeshi Kimura, for Anyang-si, Gyeonggi-do, South Korea the CREDO-Kyoto Investigators, Kyoto Medical Center, Kyoto, Japan Learning Objective: Identify which DES is better between SES and Learning Objective: identify the incidence and the long-term PES in renal insufficiency in primary PCI prognostic implication of CIN in various definitions in patients with and without chronic kidney disease 2504-517 Predictors of Contrast-induced Nephropathy After Percutaneous Coronary Intervention for CTO Lesions. 2504-524 Long-term Prognosis of Hemodialysis Patients after Coronary Interventions in the Drug-eluting Stent Era Masashi Kimura, Soichiro Ebisawa, Yoshihiro Ko, Nobuyoshi Tanaka, Kenya Nasu, Tatsuya Ito, Yoshihisa Kinoshita, Mariko Ehara, Etsuo Koichi Sano, Sho Torii, Seiichi Fukuda, Takayoshi Sato, Yutaka Tsuchikae, Mitsuyasu Terashima, Yasushi Asaskura, Osamu Katoh, Koyama, Yasuyuki Maruyama, Iwatsuki-Minami Hospital, Saitama- Takahiko Suzuki, Toyohashi Heart Center, Toyohashi, NY, Japan shi, Japan, Kita-Ibaraki City Hospital, Kitaibaraki-shi, Japan Learning Objective: evaluate the impact of CTO procedures and Learning Objective: interpret the long-term prognosis of contrast media use on renal function. hemodialysis patients after coronary interventions in drug-eluting stent era 2504-518 Hyperglycemia and Contrast-Induced Acute Kidney Injury: Threshold for Injury 2505 ENDOVASCULAR AND NEW TECHNOLOGIES William B. Hillegass, Jr., Reza E. Ershadi, Marc A. Mayhew, Vijay K. Misra, Silvio E. Papapietro, Brigitta C. Brott, Gilbert J. Zoghbi, Tuesday, March 16, 2010, 9:30 a.m. - 10:30 a.m. University of Alabama at Birmingham, Birmingham, AL Georgia World Congress Center, Hall B5 Learning Objective: Identify level of hyperglcemia that may be a risk Presentation Hour: 9:30 a.m. - 10:30 a.m. factor for acute kidney injury with contrast administration. CME/CE Hours: 1

2504-520 The Impact of Race on In-hospital Outcomes in 2505-418 Procedure Type Risk Groups for Pediatric and Hemodialysis Patients Undergoing Percutaneous Congenital Cardiac Catheterization Coronary Intervention Lisa T. Bergersen, Kimberlee Gauvreau, Audrey Marshall, Jacqueline Luis Gruberg, Puja B. Parikh, Allen Jeremias, Srihari S. Naidu, Kreutzer, Robert Beekman, Russel Hirsch, Susan Foerster, David Richard A. Shlofmitz, Sorin J. Brenner, Thomas Pappas, Kevin P. Balzer, Julie Vincent, William Hellenbrand, Ralf Holzer, John Marzo, David L. Brown, Stony Brook University, Stony Brook, NY, Cheatham, John Moore, James Lock, Kathy Jenkins, Children’s Winthrop University Hospital, Mineola, NY Hospital Boston, Boston, MA Learning Objective: Assess the impact of hemodialysis in African Learning Objective: Describe types or procedures and associated American patients undergoing PCI risk rate as well as importance as a tool for outcome assessment

Characterization of High Levels of Radiation 2504-521 New Generation Drug-Eluting Stents Implantation in 2505-419 Patients With Chronic Kidney Disease Exposure in a Large Volume Pediatric Cardiac Catheterization Lab Konstantinos Toutouzas, Chrysoula Patsa, Costas Tsioufis, Eleftherios Tsiamis, Anastasios Spanos, Costas Tentolouris, George R. Verghese, Doff B. McElhinney, Lisa Bergersen, M.D., Dimitrios Tousoulis, Christodoulos Stefanadis, Hippokration Children’s Hospital Boston, Boston, MA Hospital, Athens, Greece Learning Objective: Identify variation in radiation exposure during Learning Objective: to evaluated the clinical outcomes of the new pediatric cardiac catheterization generation DES implantation in patients with an isolated lesion in the proximal segment of the left anterior descending artery and chronic kidney disease A212 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2505-420 Facilitating Treatment of Pulmonary Atresia with 2505-432 Comparison of Amplatzer® PFO Versus CardioSEAL/ Radiofrequency (RF) Energy without RF Catheter STARflex® Versus Gore Helex Devices in Closure of Perforation Patent Foramen Ovale: A Single-Center Experience

James Y. Coe, Prakul Chanthong, John Dyck, University of Alberta, Babak Haddadian, Alix J. Tercius, Naoyo Mori, Louie Kostopoulos, Edmonton, AB, Canada Satish Velagapudi, Kambiz Shetabi, Krishna Nagendran, Hani Hashim, Abdelazim Hashim, Andleeb Bangash, Anjan Gupta, Suhail Learning Objective: Distinguish the different approaches, Allaqaband, Tanvir Bajwa, Aurora Cardiovasc Svcs, Aurora Sinai/ advantages and disadvantages of radiofrequency perforation of the St. Luke’s Med Ctrs, Univ Wisconsin Sch Med & Public Health-MCC, atretic pulmonary valve. Milwaukee, WI, Center for Urban Population Health, University of Wisconsin-Milwaukee, Milwaukee, WI 2505-421 Improving Safety in the OR: An Intraoperative Improvement Initiative in Pediatric Cardiac Surgery Learning Objective: to recognize potential risks and benefits of different devices available in the market for percutaneous closure Megan Moser, Peter Manning, Traci Ashcraft, Pirooz Eghtesady, of PFO. Cincinnati Children’s Hospital, Cincinnati, OH Learning Objective: Identify how a systematic approach to initiate 2505-433 Degree And Distribution Of Aortic Annulus improvement can be effective and change outcomes. Calcification As A Predictive Factor For Pacemaker i2 Summit Implantation After Corevalve Tavi. A Ct Driven, 2505-422 Most Recurrent Events After Patent Foramen Ovale Prospective, Single-center Study Closure are not due to Residual Shunts

(Interventional Cardiology) Georg Latsios, Seyrani Yücel, Daniel John, Ralf Mueller, Lutz Julia T. Wallenborn, Nina Wunderlich, Horst Sievert, Cardiovascular Buellesfeld, Barthel Sauren, Ulrich Gerckens, Eberhard Grube, Center Frankfurt, Frankfurt, Germany HELIOS Heart Center Siegburg, Siegburg, Germany Learning Objective: Identify potential causes of recurrent events Learning Objective: To describe and interpret the relation of valve after PFO Closure calcification and need for pacemaker implants after TAVI

2505-429 Catheter Closure of Atrial Septal Defect in Geriatric 2505-435 Anatomic suitability for Present and Next Population (> 70 years old) Generation Transcatheter Aortic Valve Devices

Koji Nakagawa, Teiji Akagi, Yasufumi Kijima, Manabu Taniguchi, Hasan Jilaihawi, Jan Kovac, Derek Chin, Reda Ibrahim, Tomasz Spyt, Kengo Kusano, Hiroshi Itoh, Shunji Sano, Department of Anita Asgar, Raoul Bonan, Montreal Heart Institute, Montreal, QC, Cardiovascular Medicine, Okayama University Graduate School of Canada, Glenfield Hospital, Leicester, United Kingdom Medicine, Okayama, Japan Learning Objective: interpret the anatomical suitability for different Learning Objective: evaluate TAVI devices.

2505-430 Atrial Septal Defect Occlusion Using an Immediate 2505-436 Medium Term Longitudinal Follow Up of All Patients ReleasePatch Method ; Early Clinical Experience Referred to a Transcatheter Aortic Valve Multi- Disciplinary Team. Eleftherios B. Sideris, Ali Zeinaloo, Kayhan S. Zanjani, Natalia Borisova, Manolis Pursanov, Athenian Institute of Pediatric Patrick A. Calvert, Isma Rafiq, Baris A. Ozdemir, William Watson, Cardiology, Athens, Greece, Tehran University of Medical Sciences, Simon Hansom, Stephen T. Webb, Bushra S. Rana, Evelyn M. Lee, Tehran, Iran (Islamic Republic of) John Dunning, Rosemary A. Rusk, Catherine Sudarshan, Steven Tsui, Leonard M. Shapiro, Cameron G. Densem, Papworth NHS Learning Objective: to evaluate a new ASD occlusion method Foundation Trust Hospital, Cambridge, United Kingdom, Division of Cardiovascular Medicine, University of Cambridge, Cambridge, 2505-431 Markedly Elevated B-type Natriuretic Peptide United Kingdom Predicts Shock in Obstructive Cardiac Lesions on Systemic Side Learning Objective: Evaluate the importance of a multi-disciplinary team in assessing high risk patients with severe aortic valvular Srikant Das, Kevin Maher, Sibley Heart Center, Children’s Healthcare stenosis and understand the importance of valve replacement of Atlanta, Emory University, Atlanta, GA therapy Learning Objective: Recognize high BNP as a marker of left side Transcatheter Aortic Valve Implantation Under (systemic) obstructive lesion in infants with shock.. 2505-437 Conscious Sedation Versus General Anesthesia With Intubation

Itsik Ben-Dor, Ron Waksman, Lowell F. Satler, Yanlin Li, Asmir I. Syed, Sara D. Collins, Gabriel Maluenda, Manuel A. Gonzalez, Kohei Wakabayashi, Cedric Delhaye, Michael A. Gaglia, Petros Okubagzi, Rebecca Torguson, Zhenyi Xue, William O. Suddath, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard, Washington Hospital Center, Washington, DC, DC Learning Objective: To examine the feasibility and safety of TAVI under conscious sedation and compare the clinical outcome to those patients who underwent general anesthesia JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A213

2505-438 Mortality on the Waiting List for Transcatheter 2505-447 The Cardiac Benefits of Renal Artery Stenting Aortic Valve Implantation. A Single Center Osami Kawarada, Yoshiaki Yokoi, Nobuyuki Morioka, Akihiro Experience from Vancouver, Canada Higashimori, Kishiwada Tokushukai Hospital, Kishiwada, Osaka, Edgar Tay, Eve Aymong, Namal Wijesinghe, Fabian Nietlispach, Japan Ronen Gurvitch, DA Wood, Ronald Carere, Jian Ye, Anson Cheung, Learning Objective: evaluate cardiac benefits of renal artery John Webb, St. Paul’s Hospital, Vancouver, BC, Canada stenting. Learning Objective: Risk stratify patients waiting for TAVI 2505-449 Nitinol Stenting for Chronic Total Occlusion (CTO) in 2505-439 Left Atrial Stasis and VWF-ADAMTS 13 System in Superficial Femoral Artery (SFA), Long-Term Clinical Aatrial Fibrillation Outcomes from Multicenter Registry. Cardiology) (Interventional

Waldemar E. Wysokinski, Ewa Konik, Robert D. McBane, II, Susan J. Yasunari Sakamoto, Keisuke Hirano, Toshiya Muramatsu, Yoshimitsu Soga, Osamu Iida, Yokoi Hiroyoshi, Shinsuke Nanto,

Eifert Rain, Dong Chen, Edyta Sutkowska, Thomas G. McLeod, Paul i2 Summit A. Friedman, Naser M. Ammash, Mayo Clinic, Rochester, MN Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan Learning Objective: To evaluate the relationship between VWF Learning Objective: evaluate concentration and activity and the risk of left atrial appendage thrombus and stroke in atrial fibrillation. 2505-450 Long-term Mortality After Endovascular Treatment For Critical Limb Ischemia With Tissue Loss 2505-443 Optical Coherence Tomography Imaging to Evaluate Carotid Artery Stents: Safety, Feasibility, and Osami Kawarada, Yoshiaki Yokoi, Nobuyuki Morioka, Akihiro Higashimori, Shinji Shiotani, Kishiwada Tokushukai Hospital, Technique Kishiwada, Osaka, Japan Bernhard Reimers, Luca Favero, Eugenio Stabile, Salvatore Saccà, Learning Objective: identify high risk patients after endovascular Paolo Rubino, Mirano Cardiology Dept., Mirano, Italy, Clinica treatment for critical limb ischemia Montevergine, Mercogliano, Italy Learning Objective: Understand technique of intracarotid, post 2505-451 Effect of Time Delays on Outcomes of Acute Limb stent OCT imaging. Understand phenomenons as plaque prolaps, Ischemia stent coverage, different appearance of open vs closed cell carotid stents. Hong H. Keo, Sue Duval, Iris Baumgartner, Niki C. Oldenburg, Michael R. Jaff, James M. Peacock, Alexander S. Tretinyak, Adnan One-Year Clinical Outcomes after Treatment of Z. Rizvi, Timothy D. Henry, M. Darragh Flannery, Yale L. Wang, Peter 2505-444 B. Alden, Alan T. Hirsch, on behalf of the FRIENDS Investigators, Carotid Stenosis with Carotid Artery Stenting and Minneapolis Heart Institute Foundation at Abbott Northwestern Carotid Endarterectomy in the Medicare Population Hospital, Minneapolis, MN FenWei Wang, Michael Del Core, Aryan Mooss, Thomas Lanspa, Learning Objective: Understand the importance of diagnostic delays Stephanie Maciejewski, Dennis Esterbrooks, Creighton University, and its associated shortterm outcome in patients with ALI Omaha, NE Learning Objective: To evaluate one-year outcomes of carotid artery 2505-452 Determinants of Procedural Failure in stenting in the Medicare population Contemporary Percutaneous Vascular Intervention: Insights from the Blue Cross Blue Shield of 2505-445 Is Carotid Stenting A Durable Technique? Acute And Michigan Cardiovascular Consortium Up To 7 Years Long-term Clinical Results From A Paul Michael Grossman, Khan Munir, Stanley J. Chetcuti, Daniel Single-center Consecutive Series Of Patients S. Menees, Thomas P. Davis, Roberto A. Corpus, Steven K. Wang, Piero Montorsi, Costanza Boiti, Stefano Galli, Paolo Ravagnani, Arthur Riba, David Share, Hitinder S. Gurm, University of Michigan Marco Agrifoglio, Franco Fabbiocchi, Daniela Trabattoni, Giovanni Hospitals and Health Center, Ann Arbor, MI Teruzzi, Antonio Bartorelli, Gianluca Pontone, Cesare Fiorentini, Learning Objective: Identify patient and clinical factors that are Institute of Cardiology University of Milan, Milan, Jamaica associated with a failed percutaneous vascular intervention. Learning Objective: interpretate acute and long-term results of CAS 2505-453 Importance of Out-patient Surveillance for 2505-446 Completeness of Revascularization and Long Achieving Long-term Patency After Percutaneous Term Survival in Patients eligible for Percutaneous Revascularization of Long Femoral Artery Disease Coronary Intervention: A Meta-Analysis of Thomas M. Todoran, Gerard Connors, Brian A. Engelson, Piotr Multivessel Coronary Artery Disease Studies. S. Sobieszczyk, Andrew C. Eisenhauer, Scott Kinlay, VA Boston Vikas Aggarwal, Manjeet Singh, Swapnil Rajpathak, Atul M. Limaye, Healthcare Systrm, West Roxbury, MA, Brigham and Women’s Benjamin Romick, Vankeepuram S. Srinivas, Jacobi Medical Center, Hospital, Boston, MA Bronx, NY, Montefiore Medical Center, Bronx, NY Learning Objective: Demonstrate a novel approach for percutaneous Learning Objective: Compare clinical outcomes based on treatment of femoral artery disease. completeness of revascularization in patients with multivessel coronary artery disease undergoing percutaneous coronary intervention and stent implantation. A214 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2505-455 Comparison Of Transradial Coronary Intervention 2505-461 Efficacy and Safety of 4F New Transradial Between Right And Left Radial Approach Diagnostic Catheter; RM and CR Catheter for Engaging Both Left and Right Coronary Arteries Young Jin Youn, Junghan Yoon, Sang Woo Han, Jun-Won Lee, Joong Kyung Sung, Nam Seok Lee, Jang-Young Kim, Seung Hwan Lee, Seung Woon Rha, Ji Young Park, Kanhaiya L. Poddar, Sureshkumar Kyung-Hoon Choe, Wonju Christian Hospital, Wonju, South Korea Ramasamy, Lin Wang, Byoung Geol Choi, Ji Bak Kim, Seung Yong Shin, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Learning Objective: Which vascular access would be helpful during Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Cardiovascular TRI Center, Korean University Guro Hospital, Seoul, South Korea 2505-456 Transradial Percutaneous Intervention In Acute Learning Objective: The present study aimed to investigated the ST Elevation Myocardial Infarction Using A Single Efficacy and Safety of 4F New Transradial Diagnostic Catheter; RM Heartrail Ikari Left Guider and CR Catheter for Engaging Both Left and Right Coronary Arteries

Jeremy Chow, Vern Hsen Tan, Chong Hiok Tan, Sea Hing Ong, Yew 2505-462 The Angio-Seal Evolution Multicenter Registry: Seong Goh, Siang Chew Chai, Changi General Hospital, Singapore, Multivariate Analysis of Vascular Complications in Singapore High Risk Patients Learning Objective: evaluate the feasibilty of using a single guider

i2 Summit Robert J. Applegate, Zoltan Turi, Naveen Sachdev, Abdel Ahmed, Art for transradial diagnostic angiography and therapeutic angioplasty Szyniszewski, Malcolm Foster, Antonis Pratsos, Timothy Shapiro, for STEMI patients Steven J. Yakubov, David M. Shavelle, Wake Forest University School of Medicine, Winston-Salem, NC (Interventional Cardiology) 2505-457 Comparative Effectiveness of Radial and Femoral Approaches to Percutaneous Coronary Intervention Learning Objective: To identify patient and procedural factors on Long-term Outcomes: A Report From The Nhlbi associated with vascular complications after use of a closure Dynamic Registry device.

Sunil V. Rao, Faith Selzer, Eric D. Peterson, Suresh R. Mulukutla, 2505-463 The Angio-Seal Evolution Multicenter Registry: The Joon S. Lee, Howard A. Cohen, David O. Williams, Alice K. Jacobs, Learning Curve Associated With a New Closure Sheryl F. Kelsey, Oscar C. Marroquin, The University of Pittsburgh, Device Pittsburgh, PA, The Duke Clinical Research Institute, Durham, NC Robert J. Applegate, Zoltan Turi, Naveen Sachdev, Abdel Ahmed, Art Learning Objective: Discuss the association between radial Szyniszewski, Malcolm Foster, Antonis Pratsos, Timothy Shapiro, approach to PCI and outcomes Steven J. Yakubov, David M. Shavelle, Wake Forest University School of Medicine, Winston-Salem, NC 2505-458 Comparative Effectiveness of Radial Access and Bivalirudin on PCI-Related Bleeding Events: Analysis Learning Objective: To identify the learning curve associated with from the National Cardiovascular Data Registry® closure device use.

Steven P. Marso, Amit Amin, John A. House, Kevin F. Kennedy, John 2505-464 Safety And Efficacy Of A Novel Metal Catheter In A. Spertus, Sunil V. Rao, John C. Messenger, John S. Rumsfeld, Mid Chronic Total Occlusion Lesions. -Corsair First-In- America Heart Institute, Kansas City, MO, Duke Clinical Research Man (FIM) Registry- Institute, Durham, NC Masashi Kimura, Etsuo Tsuchikae, Osamu Katoh, Nobuyoshi Learning Objective: Understand the comparative effectiveness of Tanaka, Kenya Nasu, Tatsuya Ito, Yoshihisa Kinoshita, Mariko Ehara, bivalirudin and radial access on bleeding events in PCI patients Mitsuyasu Terashima, Yasushi Asaskura, Takahiko Suzuki, Toyohashi Heart Center, Toyohashi, NY, Japan 2505-459 Incidence, Range and Clinical Impact of Hemoglobin Decrease after Transradial Coronary Learning Objective: evaluate the safety and feasibility of a novel Stenting and Maximal Antiplatelet Therapy. metal catheter (CORSAIR) in the retrograde approach for CTO recanalization. Olivier F. Bertrand, Josep Rodés-Cabau, Éric Larose, Stéphane Rinfret, Stéphane Rinfret, Jean-Pierre Déry, Onil Gleeton, Can M. 2505-489 Efficacy and Long Term Safety of StarClose™, an Nguyen, Guy Proulx, Louis Roy, Olivier Costerousse, Paul Poirier, Extra Luminal Clip Vascular Closure System, for Robert De Larochellière, Quebec Heart-Lung Institute, Quebec City, Hemostasis of Arterial Punctures Distal to Common QC, Canada Femoral Artery Bifurcation After Percutaneous Learning Objective: evaluate the blood loss after transradial Coronary Interventions coronary stenting Payam Dehghani, Atif Mohammad, Daniel Marcuzzi, Tony Hong, Transradial Approach is Associated with Lower Melma Evangelista, Howard Leong-Poi, Asim N. Cheema, St. 2505-460 Michael’s Hospital, Toronto, ON, Canada Bleeding Complications in Patients Undergoing Percutaneous Coronary Intervention with Learning Objective: To determine immediate efficacy and long term Glycoprotein IIb/IIIa Inhibitors safety of StarClose for hemostasis in arterial punctures distal to common femoral artery Arthur Kerner, Eitan Abergel, Michael Berger, Majdi Halabi, Monther Boulus, Raphael Beyar, Ariel Roguin, Rambam Health Care Campus, Haifa, Israel Learning Objective: Identify the superiority of radial access in preventing bleeding complications during PCI with the use of GPI JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A215

2505-490 Efficacy and Safety of the Nitinol Clip-Based 2505-496 Conservative Versus Invasive Management Strategy Vascular Closure Device (Starclose) for Femoral for Retroperitoneal Hemorrhage After Percutaneous Arterial Cannulation at the Bifurcation: A Propensity Coronary Intervention Score Adjusted Analysis Gabriel Maluenda, Cedric Delhaye, Manuel A. Gonzalez, Itsik Sripal Bangalore, Venkatesan Vidi, Matthew T. Galvin, Christopher B. Ben-Dor, Michael A. Gaglia, Sara D. Collins, Kohei Wakabayashi, Liu, Kevin P. Mullen, Kathryn M. Poulin, Holly Rand, Lisa D. Samson, Nicholas N. Hanna, Rebecca Torguson, Zhenyi Xue, William O. Leigh Teittinen, Pinak B. Shah, Frederick G. Welt, Frederic Resnic, Suddath, Lowell F. Satler, Kenneth M. Kent, Joseph Lindsay, Augusto Brigham and Women’s Hospital, Boston, MA D. Pichard, Nelson L. Bernardo, Ron Waksman, Washington Hospital Center, Washington, DC Learning Objective: Demonstrate the safety of Starclose device for closure of femoral bifurcation cannulation Learning Objective: Evaluate the role of therapeutic approach to Cardiology) (Interventional manage this serious bleeding complication 2505-491 Vascular Closure Device Versus Mechanical Compression for Prevention of Complications: A 2505-497 Safezone Arteriotomy Predicts Vascular i2 Summit Propensity Score Adjusted Analyses of 28487 Complications Among Men but Not Women Patients Undergoing Coronary Diagnostic and Undergoing Cardiac Catheterization Interventional Procedures Stefan Lischke, Bina Ahmed, Leigh A. Holterman, Harold L. Sripal Bangalore, Venkatesan Vidi, Pinak B. Shah, Federick G. Welt, Dauerman, University of Vermont, Burlington, VT Suwada Hinds, Frederic Resnic, Brigham and Women’s Hospital, Learning Objective: identify gender specific risk factors for vascular Boston, MA complications after cardiac catheterization Learning Objective: Evaluate the efficacy of vascular closure device at preventing complications when compared to manual compression 2505-498 Impact of Length and Hydrophilic Coating of the Introducer Sheath on Radial Artery Spasm during 2505-492 Long Term Outcomes Associated with Vascular Transradial Coronary Intervention: A Randomised Closure Device Use in Patients Undergoing Study Percutaneous Coronary Intervention Via the Sudhir Rathore, Rodney H. Stables, Maheswar Pauriah, Abdul Femoral Approach: A Propensity Score Adjusted, Hakeem, Joseph D. Mills, Nick Palmer, Raphael A. Perry, John Propensity Score Matched Analysis L. Morris, Liverpool Heart and Chest Hospital, Liverpool, United Sripal Bangalore, Venkatesan Vidi, Frederick G. Welt, Pinak B. Shah, Kingdom Frederic Resnic, Brigham and Women’s Hospital, Boston, MA Learning Objective: This study evaluates the impact of hydrophilic Learning Objective: Evaluate the long term outcomes when using coating and length of introducer sheath on radial artery spasm vascular closure devices during transradial coronary procedures. Location of Femoral arteriotomy Site Using 2505-493 Learning Curve in the Use of StarClose Vascular 2505-500 Closure Device: An Analysis of the National Anatomical Landmarks: Correlation with Access Cardiovascular Data Registry Site Complications

Venkatesan Vidi, Nipun Arora, Tracy Y. Wang, Fang-Shu Ou, David Sridevi Pitta, Abhiram Prasad, Gautam Kumar, Charanjit S. Rihal, Dai, Michael Matheny, Frederic S. Resnic, Brigham and Women’s David R. Holmes, Mayo Clinic, Rochester, MN Hospital, Boston, MA, Duke Clinical Research Institute, Durham, NC Learning Objective: Identify optimal versus alternative arteriotomy Learning Objective: To describe the institutional learning curve with locations and its relation to vascular complications the adoption of StarClose vascular closure device 2505-501 Mechanical Compression Devices Are Better Than Manual Compression Following Percutaneous 2505-494 PCI-Related Bleeding Risk by Access and Non- Access Site in the National Cardiovascular Data Coronary Intervention Registry® Abdelazim Hashim, Naoyo Mori, Satish Velagapudi, Babak Haddadian, Raaid Museitif, Angela Schlemm, Suhail Allaqaband, Steven P. Marso, Amit Amin, John A. House, Kevin F. Kennedy, Tanvir Bajwa, Anjan Gupta, Aurora Cardiovasc Svcs, Aurora Sinai/ John A. Spertus, Sunil V. Rao, David J. Cohen, Mid America Heart St. Luke’s Med Ctrs, Univ Wisconsin Sch Med & Public Health-MCC, Institute, Kansas City, MO, Duke Clinical Research Institute, Milwaukee, WI, Center for Urban Population Health, University of Durham, NC Wisconsin-Milwaukee, Milwaukee, WI Learning Objective: Distinguish between risk of bleeding at PCI Learning Objective: assess differences in risk of vascular access site and non-access sites complications, all-cause mortality and length of hospital stay between manual compression and mechanical compression devices Access Site Management in the Cardiac Transplant 2505-495 (Fem-Stop; C-clamp) following PCI. Patient Undergoing Catheterization: Safety and Efficacy of Vascular Closure Devices

George V. Moukarbel, Patricia M. Campbell, Michael M. Givertz, Frederic S. Resnic, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA Learning Objective: understand the efficacy and safety of vascular closure devices in cardiac transplant recipients A216 ABSTRACTS: i2 Summit (Interventional Cardiology) JACC March 9, 2010

2505-502 Transluminal Retrieval of Vascular Stent Without 2505-508 Novel 19F MRI and CT Trackable Microencapsulated Surgical Procedures: In Vitro and In Vivo Studies Mesenchymal Stem Cells for Treating Peripheral With Originally Designed Catching Device Arterial Disease

Masayuki Tsuchida, Masa-aki Kawashiri, Hayato Tada, Chiaki Yingli Fu, Dorota Kedziorek, Steven Shea, Ronald Ouwerkerk, Nakanishi, Katsuharu Uchiyama, Masakazu Yamagishi, Division of Gary Huang, Tina Ehtiati, Robert Krieg, Jeff WM Bulte, Dara L. Cardiovascular Medicine, Kanazawa University Graduate School of Kraitchman, Johns Hopkins University, Baltimore, MD Medicine, Kanazawa, Japan Learning Objective: demonstrate stem cell monitoring and non- Learning Objective: evaluate our new method to retrieve the stent. invasive tracking for ischemic arterial disease.

2505-503 Safety and Efficacy of Angio-Seal™ Vascular 2505-509 Endovascular Cellular Paving For Vascular Repair Closure Device Following Percutaneous Coronary Using Acoustic Radiation Force Intervention Catalin Toma, Brion Winston, Andrew Fisher, Jianjun Wang, Xucai Abdelazim Hashim, Naoyo Mori, Satish Velagapudi, Babak Chen, Michelle Grata, William Wagner, Flordeliza S. Villanueva, Haddadian, Raaid Museitif, Angela Schlemm, Suhail Allaqaband, University of Pittsburgh Medical Center, Pittsburgh, PA, Center for Tanvir Bajwa, Anjan Gupta, Aurora Cardiovasc Svcs, Aurora Sinai/ Ultrasound Molecular Imaging and Therapeutics, Pittsburgh, PA

i2 Summit St. Luke’s Med Ctrs, Univ Wisconsin Sch Med & Public Health-MCC, Learning Objective: evaluate ultrasound based application of cell Milwaukee, WI, Center for Urban Population Health, University of therapy for vascular repair Wisconsin-Milwaukee, Milwaukee, WI

(Interventional Cardiology) Learning Objective: to compare length of hospital stay, rate of 2505-510 A New Method To Measure Necrotic Core And Calcium vascular complications, and all-cause mortality between Angio- Content In Coronary Plaques Using Intravascular Seal™ VCD and manual compression or mechanical compression Ultrasound Radiofrequency-based Analysis devices following PCI. Eun Seok Shin, Hector M. Garcia-Garcia, Patrick W. Serruys, Ulsan 2505-504 Novel Technique of Duplex Ultrasound Guided University Hospital, Ulsan, South Korea, Thoraxcenter, Erasmus Cannulation of Complete Flush Occlusion of SFA medical center, Rotterdam, The Netherlands and Bypass Graft Learning Objective: evaluate for necrotic core and calcium very quickly in Cath. Lab. Nelson L. Bernardo, Gabriel Maluenda, Manuel A. Gonzalez, MD, Sara D. Collins, Vishal Gupta, Marie A. Bilyeu, Raswork G. Outcome of Transcatheter Aortic Valve Implantation Gebremeskel, Stephen A. Boyd, Rebecca Torguson, Ron Waksman, 2505-514 Washington Hospital Center, Washington, DC in Octogenarians in Comparison to Younger Patients: Results of the German Registry on Learning Objective: Describe how to utilize duplex ultrasound as Transcatheter Aortic Valve Implantations the primary imaging modality to guide recanalization of completely “flush” occluded vessels that show no residual “ostial stumps” Lutz Buellesfeld, Ulrich Gerckens, Harald Mudra, Gerhard C. Schuler, angiographically. Ralf Zahn, Horst Sievert, Raimund Erbel, Rainer Hambrecht, Georg Nickenig, Karl-Eugen Hauptmann, Christoph Naber, Hans Rainer 2505-506 Upregulation of Hypoxia-Inducible Factor by Figulla, Stefan Sack, Joachim Senges, Eberhard Grube, HELIOS Di-Methyl Oxalyl Glycine (DMOG) Increases Heart Center Siegburg, Siegburg, Germany Neovascularization Within Ischaemic Myocardium in Learning Objective: To demonstrate the realtion of age and a Porcine Coronary Occlusion Model success/outcome after TAVI Damian John Kelly, Jasmin Mecinovic, Nadine Arnold, Kim Suvarna, Comparison of Transfemoral and Transapical Aortic Christopher J. Schofield, Julian Gunn, Anthony H. Gershlick, 2505-515 University of Leicester, Leicester, United Kingdom, University of Valve Replacement: Results of the German Registry Sheffield, Sheffield, United Kingdom on Transcatheter Aortic Valve Implantations Learning Objective: Describe the effect of a novel angiogenic Ulrich Gerckens, III, Harald Mudra, Gerhard C. Schuler, Ralf Zahn, treatment for chronic total occlusion Horst Sievert, Raimund Erbel, Rainer Hambrecht, Georg Nickenig, Karl-Eugen Hauptmann, Christoph Naber, Hans Rainer Figulla, 2505-507 The First US Study to Assess the Feasibility Stefan Sack, Jochen Senges, Lutz Buellesfeld, Eberhard Grube, and Safety of Endocardial Delivery of Allogenic HELIOS Heart Center Siegburg, Siegburg, Germany Mesenchymal Precursor Cells in Patient With Heart Learning Objective: To describe current outcome results Failure: Three-Month Interim Analysis of transfemoral and transapical transcatheter aortic valve implantations in real world practice Nabil Dib, Tim Henry, Anthony De Maria, Silviu Itescu, Megan McCarthy, Susan Jaggar, Nicole Taylor, Ann Campbell, Henry Krum, TandemHeart Percutaneous Ventricular Assist Kendra Bartels, Donna Skerrett, Emerson Perin, Catholic Healthcare 2505-516 Device for the Treatment of Refractory Cardiogenic West, Gilbert, AZ Shock: A Single Center Experience Learning Objective: Describe AMPC transplantation via endoventricular delivery to patients with heart failure. Thomas M. Todoran, Sripal Bangalore, Scott Kinlay, Andrew C. Eisenhauer, Piotr S. Sobieszczyk, Brigham and Women’s Hospital, Boston, MA Learning Objective: Report clinical experience using TandemHeart percutaneous ventricular assist device in patients with refractory cardiogenic shock. JACC March 9, 2010 ABSTRACTS: i2 Summit (Interventional Cardiology) A217

2505-517 Trans-aortic Implantation Of The Medtronic 2505-524 Clinical Experience with a Sirolimus-eluting Nitinol Corevalve Prosthesis. Successful Implantation Stent in a Biodegradable Polymer Matrix using the Through An Alternative Access Route CardioMind® 0.014” Sparrow® Stent System

Ulrich Gerckens, III, Ralf Mueller, Stein Iversen, Thomas Felderhoff, Roberto Botelho, Stefan Verheye, Robert J. Whitbourn, Rodolfo Barthel Sauren, Bernfried Zickmann, Lutz Buellesfeld, Eberhard Staico, Jose R. Costa, Alexandre C. Abizaid, Instituto do Coração Grube, HELIOS Heart Center Siegburg, Siegburg, Germany do Triângulo, Uberlandia, Brazil, Instituto Dante Pazzanese de Cardiologia, São Paolo, Brazil Learning Objective: Demonstrate a new approach for TAVI procedures Learning Objective: understand a novel technology that may lead to improved clinical outcomes for the treatment of small vessel

2505-518 Radiofrequency Energy - A New Approach to Shrink disease Cardiology) (Interventional the Mitral Annulus: A Cross-Species Study 2505-531 The Impedance Cardiogram Is An Indicator Of CPR

Richard R. Heuser, Duane Dickens, Thomas Witzell, St. Luke’s Effectiveness For Out-of-hospital Cardiac Arrest i2 Summit Hospital and Medical Center, Phoenix, AZ, University of Arizona, Victims Tucson, AZ Rebecca C. Di Maio, NIBEC, University of Ulster, Belfast, AL, United Learning Objective: Demonstrate the ability of RF energy to modify Kingdom, The Heart Centre, Royal Victoria Hospital, Belfast, AL, collagen in a cross species study. United Kingdom 2505-520 Intracoronary Optical Coherence Tomography (OCT) Learning Objective: understand the potential application of and Histology 2, 3 And 4 Years After Implantation Impedance Cardiography in the treatment of sudden cardiac arrest of Bioresorbable Everolimus-eluting Stents in a Porcine Coronary Model: an Attempt to Decipher 2505-532 Removal of Contrast Media from the Coronary The Human OCT Images in The Absorb Trial Sinus Attenuates Renal Injury After Coronary Angiography and Intervention Yoshinobu Onuma, Tskayuki Okamura, Nieves Gonzalo, Evelyn Regar, Willem van der Giessen, Laura Perkins, Jennifer Powers, David M. Kaye, Peter Ruygrok, Craig Juergens, Horst Sievert, Mark Richard Rapoza, Renu Virmani, Thorax Center, Erasmus MC, Richards, James Blake, Robert Whitbourn, Omar Farouque, Terry Rotterdam, The Netherlands Pertile, Stephen Duffy, Alfred Hospital, Melbourne, MN, Australia Learning Objective: interpret alteration of bioresorbable everolimus- Learning Objective: Understand the causes and potential prevention eluting stent in OCT images with corresponding histology in the of contrast-induced nephropathy porcine coronary artery model 2505-533 Assessment by Optical Coherence Tomography of a 2505-521 Stent Degradation of Novel Fully Bioabsorbable Dedicated Drug Eluting Stent With Biodegradable Salicylate-Based Sirolimus-Eluting Stent Evaluated Polymer for the Inhibition of Neovascularization and by OCT in Pig Coronary Artery Neointimal Hyperplasia

Daisuke Matsumoto, Toshiro Shinke, Sarah Geva, Nicolas Chronos, Konstantinos Toutouzas, Elefterios Tsiamis, Andreas Synetos, Refat Jabara, Saint Joseph’s Translational Research Institute, Antonis Karanasos, Elli Stefanadi, Nicholas Kipshidze, Atlanta, GA Christodoulos Stefanadis, 1st Department of Cardiology, Hippokration Hospital, Athens, Greece Learning Objective: demonstrate stent degradation of novel fully bioabsorbable salicylate-based sirolimus-eluting etent evaluated by Learning Objective: evaluate the pre-clinical effectiveness of a OCT in pig coronary artery dedicated stent for the inhibition of angiogenesis

2505-522 A Newly Developed Rapamycin-Eluting Stent with 2505-534 A Novel Method For Direct Correlation Of a Biodegradable Polymer reduces Neointimal Angiography And Endovascular Diagnostic Tools In Formation while Allowing Greater Endothelialization Human Coronary Arteries In Vivo.

Marc M. Vorpahl, Gaku Nakazawa, Pinar Nebol, Frank Kolodgie, Johannes Rieber, Simone Prummer, Martin Schmidt, Harald Rittger, Renu Virmani, CV Path Institute, Gaithersburg, MD, Alvimedica Medizinische Poliklinik, University of Munich, Munich, Germany, Medical, Istanbul, Turkey Krankenhaus Coburg, Coburg, Germany Learning Objective: understand that a biodegradable polymer is Learning Objective: Identify the potential of a new image based likely to be safer in man as compared to a non bioerodable polymer coregistration of angiography and IVUS

2505-523 First-in-Man Study of Low-Dose Paclitaxel -Eluting Stent with a Novel Biodegradable Coating

Daisaku Nakatani, Yasuhiro Honda, Katsuhisa Waseda, Junya Ako, Carlos Calderas, Jose A. Condado, Peter J. Fitzgerald, Stanford University Medical Center, Palo Alto, CA, Institute de Clinicas y Urologia Tamanaco Laboratorio de Hemodinamia, Caracas, Venezuela Learning Objective: We demonstrated that novel stent has similar neointimal suppression effect