Supplementary Table 4 deregulated between sporadic and radiation-induced thyroid follicular adenomas and papillary carcinomas

Gene expression values indicate the differential expression between radiation- induced and sporadic tumors, in the validation space, as the log of the average in sporadic tumors minus the log of the average gene expression of radiation-induced tumors, with associated P value.

References are indicated if the gene has already been identified in other thyroid- associated signatures, specific to either histological subtype of benign and malignant human tumors, or in thyroid cell models used to analyze molecular mechanisms associated with the expression of thyroid-specific oncogenes (RET/PTC isoforms or BRAFV600E). Most of the reported references are related to transcriptomic signatures, proteomic signatures being indicated by an asterisk. Gray lines indicate genes reported in a context of comparison between post-Chernobyl PTC vs sPTC. When the probe may hybridize to several mRNAs, the underlined symbol corresponds to what has been reported in the literature.

Accession Expression Symbol p References Number value NM_080284 ABCA6 -0,913555 0,005548 AB012959 ABCB11 0,294218 0,004044 NM_001090 ABCF1 -0,06853 0,005214 NM_005759 ABI2 -0,201307 0,005278 (33) NM_015831 ACHE 0,161246 0,003077 NM_001101 ACTB 0,055874 0,006058 (6*; 22*) NM_001105 ACVR1 0,30563 0,004762 (2) AL110226 ADAMTS7 0,319139 0,004904 NM_017482 ADD2 -0,196348 0,005386 NM_016824 ADD3 -0,053877 0,003665 (9; 14; 40) NM_022767 AEN -0,074771 0,00434 AJ277796 AFARP1 0,716371 0,002616 NM_002285 AFF3 -0,069753 0,004361 NM_133446 AGAP4 NM_001144000 AGAP5 NM_001077685 AGAP7 NM_001077686 AGAP8 -0,375998 0,004293 XM_001714786 AGAP10 NM_133447 AGAP11 XM_001716810 BMS1P5 NM_001077665 PARG NM_018046 AGGF1 -0,063496 0,004432 NM_006408 AGR2 0,067648 0,005617 (9; 26; 40) NM_004833 AIM2 0,131303 0,005831 NM_000031 ALAD -0,050542 0,005974 NM_005589 ALDH6A1 -0,176463 0,004526 (9; 33; 42) NM_181847 AMIGO2 0,388436 0,006112 (29; 35; 42) AL137349 ANKIB1 -0,162432 0,004992 NM_153697 ANKRD44 0,066539 0,003405 NM_005139 ANXA3 0,509914 0,005135 (2) NM_153000 APCDD1 0,026265 0,003601 NM_145642 APOL3 0,008207 0,005915 NM_012096 APPL1 0,082566 0,003965

NM_198098 AQP1 -0,018858 0,003388 NM_000044 AR 0,001492 0,005567 (46*; 47*) NM_018287 ARHGAP12 0,092471 0,003106 NM_015318 ARHGEF18 -0,068371 0,002895 NM_004840 ARHGEF6 -0,23221 0,008554 NM_006628 ARPP19 -0,000303 0,003171 NM_003887 ASAP2 0,276806 0,005369 NM_024997 ATF7IP2 -0,346881 0,004866 NM_001183 ATP6AP1 0,273104 0,003649 NM_001100592 ATP6V0E2 -0,172924 0,004922 (21) AB050195 ATXN3L 0,321395 0,005097 NM_006340 BAIAP2 0,217401 0,004406 NM_017935 BANK1 0,152146 0,004208 NM_000465 BARD1 -0,216157 0,006467 NM_020993 BCL7A -0,02012 0,003482 NM_001196 BID 0,194944 0,005358 (9; 17; 35) NM_033503 BMF -0,015395 0,005332 (29) NM_174897 BPIL3 0,384907 0,005604 NM_004333 BRAF 0,326932 0,006043 NM_024332 BRCC3 -0,284072 0,004126 (40) Breast cancer anti-estrogen AK022238 0,179692 0,005445 (36) resistance 1 NM_153256 C10orf47 0,195041 0,004903 NM_025125 C10orf57 0,272412 0,004643 NM_020193 C11orf30 0,257484 0,00737 NM_024113 C11orf49 0,148791 0,004517 AB046771 C12orf35 -0,320444 0,006142 NM_024738 C12orf49 0,133119 0,004185 NM_001145199 C12orf75 0,024729 0,005235 (40) NM_032849 C13orf33 0,283772 0,003905 (36) NM_001077594 C14orf73 -0,000031 0,004446 NM_001143936 C15orf61 0,048516 0,005191 BC023590 C16orf91 -0,108428 0,001968 NM_031448 C19orf12 0,185932 0,007913 NM_006333 C1D -0,486854 0,005477 NM_152365 C1orf172 0,175674 0,003633 NM_030934 C1orf25 -0,179878 0,00504 BC025793 C1orf31 0,21515 0,006105 NM_019118 C1orf91 -0,355076 0,004279 NM_031909 C1QTNF4 0,008081 0,004148 AY040873 C21orf57 0,172922 0,003487 AB023147 C22orf9 0,038717 0,006316 BC016389 C2orf18 0,134572 0,003294 NM_152519 C2orf67 -0,321364 0,005352 NM_032898 C3orf34 0,254375 0,005568 NM_001077657 C3orf43 0,121554 0,006697 NM_152997 C4orf7 -0,155305 0,003939 NM_006443 C6orf108 -0,06915 0,00573 NM_138493 C6orf129 -0,147928 0,004063 NM_152554 C6orf195 -0,174519 0,005428 NM_017994 C7orf42 -0,112545 0,005779 AJ276240 C8orf22 -0,296729 0,003998 NM_178448 C9orf140 0,206629 0,0039 XM_001718065 LOC729983 NM_152833 C9orf69 -0,135585 0,00549 NM_018956 C9orf9 -0,111956 0,004205

NM_012295 CABIN1 -0,142945 0,002518 NM_153498 CAMK1D -0,05151 0,004936 NM_004058 CAPS 0,180698 0,003756 NM_001230 CASP10 -0,158792 0,004536 NM_001226 CASP6 -0,108754 0,001986 NM_019610 CCBL2 0,116268 0,00689 NM_017918 CCDC109B -0,085189 0,004878 NM_021827 CCDC81 0,355611 0,004569 NM_018318 CCDC91 -0,047793 0,003635 NM_002990 CCL22 0,118226 0,005356 NM_002983 CCL3 NM_021006 CCL3L1 -0,180274 0,004022 NM_001001437 CCL3L3 NM_002984 CCL4 NM_001001435 CCL4L1 0,410964 0,005644 (32) NM_207007 CCL4L2 NM_004701 CCNB2 -0,15902 0,004482 (33; 40) NM_053056 CCND1 0,181877 0,005013 (1*; 8; 9; 24; 25; 26; 40; 47*) NM_004060 CCNG1 0,539894 0,003328 (7) NM_016602 CCR10 0,195339 0,00224 NM_001123041 CCR2 0,500564 0,002639 NM_006584 CCT6B -0,020701 0,005767 BC005220 CCT8 0,208574 0,005468 NM_000072 CD36 -0,18009 0,005939 (9; 35; 48) NM_001774 CD37 -0,02431 0,00363 NM_005191 CD80 -0,334711 0,005202 NM_012072 CD93 -0,271058 0,00478 NM_003671 CDC14B -0,244608 0,003936 (42) NM_080668 CDCA5 -0,012204 0,005404 NM_018101 CDCA8 -0,133409 0,005073 (40) NM_000389 CDKN1A 0,389541 0,006507 (9; 12; 46*; 47*) BC002741 CDNA clone IMAGE:3632909 0,001137 0,004251 BC002811 CDNA clone IMAGE:3636371 0,152643 0,003623 BC022568 CDNA clone IMAGE:4791525 0,394125 0,004276 BC042589 CDNA clone IMAGE:4819084 -0,14423 0,004635 BC039114 CDNA clone IMAGE:4831156 0,032239 0,00373 BC042737 CDNA clone IMAGE:4838334 0,241673 0,003156 BC038432 CDNA clone IMAGE:5162874 0,238874 0,00369 BC032911 CDNA clone IMAGE:5265308 -0,448785 0,004392 BC039338 CDNA clone IMAGE:5268518 -0,075083 0,0047 BC038746 CDNA clone IMAGE:5268616 -0,216706 0,005451 BC038757 CDNA clone IMAGE:5269899 0,29583 0,004835 BC043512 CDNA clone IMAGE:5269957 0,234972 0,00517 BC042992 CDNA clone IMAGE:5296720 -0,152268 0,003154 BC050301 CDNA clone IMAGE:5311269 0,283202 0,00506 BC050302 CDNA clone IMAGE:5312086 -0,512747 0,00491 CDNA FLJ10104 fis, clone AK000966 0,233257 0,002992 HEMBA1002515 CDNA FLJ12016 fis, clone AK022078 0,041957 0,005397 HEMBB1001707 CDNA FLJ12187 fis, clone AK022249 0,182669 0,005415 MAMMA1000831 CDNA FLJ12368 fis, clone AK022430 0,122902 0,006172 MAMMA1002417 CDNA FLJ12532 fis, clone AK022594 -0,124371 0,005151 NT2RM4000200 CDNA FLJ12777 fis, clone AK022839 0,394827 0,0048 NT2RP2001720 CDNA FLJ13024 fis, clone AK023086 0,320004 0,002035 NT2RP3000865

CDNA FLJ13427 fis, clone AK023489 -0,329327 0,004198 PLACE1002477 CDNA FLJ14192 fis, clone AK024254 0,028505 0,005865 NT2RP3000584 BX537548 CDNA FLJ25806 fis, clone TST07194 -0,029413 0,004592 CDNA FLJ31096 fis, clone AK055658 0,128729 0,004821 IMR321000207 CDNA FLJ34664 fis, clone AK091983 -0,157529 0,006149 LIVER2000592 CDNA FLJ34894 fis, clone AK092213 0,15776 0,005396 NT2NE2017982 CDNA FLJ36875 fis, clone AK094194 0,173395 0,004712 ASTRO2019039 CDNA FLJ37676 fis, clone AK094995 0,447322 0,005043 BRHIP2012627 CDNA FLJ38740 fis, clone AK096059 0,342596 0,004692 KIDNE2011782 CDNA FLJ39162 fis, clone AL359605 -0,179526 0,004436 OCBBF2002376 CDNA FLJ39162 fis, clone AK096481 -0,168487 0,00503 OCBBF2002376 NM_004363 CEACAM5 -0,20447 0,003574 NM_004364 CEBPA 0,163796 0,00527 NM_001813 CENPE 0,371446 0,004076 (33; 40) NM_014810 CEP350 -0,276497 0,004927 NM_032947 5 open reading frame 62 -0,013435 0,006051 AL834492 Chromosome 8 open reading frame 66 0,31101 0,004937 Clone TCA6 Cri-du-chat critical region AK095145 0,213964 0,00459 mRNA NM_003418 CNBP 0,295301 0,004941 NM_006586 CNPY3 0,246686 0,005407 (3) NM_000494 COL17A1 0,303921 0,007303 NM_000088 COL1A1 -0,382694 0,003568 (6*; 9; 31; 33; 35; 41) NM_001862 COX5B 0,282842 0,004909 NM_004718 COX7A2L 0,657525 0,004414 (40) NM_130808 CPNE4 -0,275597 0,004377 (39) NM_001886 CRYBA4 0,067606 0,008043 NM_015989 CSAD -0,234078 0,005725 NM_080610 CST9L -0,306896 0,002884 NM_138283 CSTL1 0,254366 0,005991 NM_000609 CXCL12 -0,413299 0,005124 (5; 9; 29) NM_025159 CXorf21 0,007937 0,006717 NM_018015 CXorf57 0,113307 0,005243 (26) NM_015247 CYLD -0,229729 0,004657 (23) NM_000782 CYP24A1 0,031288 0,00862 NM_001554 CYR61 -0,193334 0,004283 (8; 9; 35; 42; 44; 48) NM_017456 CYTH1 -0,025051 0,005757 NM_001343 DAB2 -0,221305 0,00526 NM_014326 DAPK2 0,237064 0,005198 (9) NM_014856 DENND4B -0,317056 0,004226 NM_024119 DHX58 -0,290076 0,005189 NM_004941 DHX8 -0,087784 0,00518 NM_001931 DLAT 0,106451 0,004656 NM_001372 DNAH9 -0,273948 0,005612 NM_005494 DNAJB6 0,33545 0,004071 NM_001379 DNMT1 -0,051154 0,004129 (40) NM_024872 DOK3 0,104296 0,004834 NM_018110 DOK4 -0,175888 0,007392 NM_005700 DPP3 0,062783 0,0047 (8) NM_001943 DSG2 0,603308 0,005098 AK055834 DUSP3 -0,105529 0,00459

NM_001398 ECH1 0,039049 0,002326 NM_001956 EDN2 -0,073141 0,005126 NM_000114 EDN3 -0,141415 0,004769 (9) NM_001957 EDNRA -0,221662 0,006157 NM_004428 EFNA1 -0,074451 0,006159 (11; 32; 40) NM_002759 EIF2AK2 0,07485 0,006954 (11; 38) NM_019843 EIF4ENIF1 -0,066689 0,005547 NM_014800 ELMO1 -0,001291 0,005406 (2; 3; 9; 13; 15; 42) NM_001033113 ENTPD8 -0,334067 0,004002 AA680300 EPAS1 0,006702 0,003216 NM_000121 EPOR -0,558997 0,00357 (42) NM_004450 ERH 0,064915 0,004459 NM_152321 ERP27 -0,109182 0,00612 NM_018948 ERRFI1 0,273325 0,005572 (31; 32) NM_000125 ESR1 0,306569 0,004986 (47*) AF047463 ESR2 0,249854 0,005445 (47*) NM_016042 EXOSC3 0,023225 0,005927 NM_004100 EYA4 -0,161181 0,006783 AK074108 FAM102A -0,100161 0,005201 NM_032182 FAM175B -0,263454 0,005581 BC018519 FAM36A 0,135497 0,004195 NM_001142864 FAM38A 0,284864 0,004664 NM_017938 FAM70A 0,547428 0,002602 (20) NM_001123168 FAM72A NM_001100910 FAM72B 0,019319 0,003201 NM_207418 FAM72D BC016722 FAT3 0,503525 0,003282 NM_000138 FBN1 -0,271578 0,00479 (3; 29; 42) NM_018438 FBXO6 0,22571 0,005362 NM_002003 FCN1 0,228616 0,004555 NM_002009 FGF7 0,099088 0,005484 (16) NM_020482 FHL5 -0,212261 0,006855 XM_001725628 FLJ30375 0,245977 0,002051 BC009262 FNBP1 -0,140799 0,003544 NM_001454 FOXJ1 -0,474001 0,007834 (9) NM_005197 FOXN3 -0,165927 0,005098 NM_005479 FRAT1 0,232537 0,005381 NM_194277 FRMD7 0,040638 0,005312 AF085831 Full-length insert cDNA clone YI40A07 -0,027651 0,007168 AF086128 Full-length insert cDNA clone ZA82A05 0,239373 0,003639 AF075013 Full-length insert cDNA YI09H09 -0,473182 0,004912 NM_003505 FZD1 0,348964 0,004665 NM_000152 GAA -0,196278 0,003897 (14; 15) NM_001468 GAGE1 0,572968 0,003835 NM_017540 GALNT10 0,390104 0,005794 (20) NM_052942 GBP5 0,061367 0,006058 NM_000161 GCH1 0,098615 0,006002 (38) NM_004752 GCM2 0,169331 0,003978 NM_004864 GDF15 0,268218 0,004298 (9; 18; 28; 29; 34; 35; 39; 44; 45) NM_004121 GGT5 0,321245 0,004633 NM_000165 GJA1 0,011037 0,003852 (3; 12; 13; 30) NM_002067 GNA11 0,262572 0,003671 NM_001502 GP2 0,247022 0,006846 NM_022913 GPBP1 -0,157842 0,003474 (40) NM_002086 GRB2 0,014916 0,00176 (4*; 8)

NM_000830 GRIK1 0,289209 0,00517 NM_002082 GRK6 -0,115487 0,004658 NM_015859 GTF2A1 0,259046 0,007218 (40) NM_005685 GTF2IRD1 0,253364 0,005594 NM_006144 GZMA -0,009895 0,004719 NM_033423 GZMH 0,095846 0,004964 (36) NM_017645 HAUS6 0,088595 0,002976 NM_001945 HBEGF 0,390083 0,005028 NM_173497 HECTD2 -0,035981 0,00231 NM_017912 HERC6 -0,158856 0,005709 NM_018645 HES6 0,3535 0,005567 NM_005320 HIST1H1D 0,118355 0,007062 NM_003521 HIST1H2BM -0,198606 0,005915 NM_006120 HLA-DMA -0,183031 0,005664 (10) NM_002120 HLA-DOB 0,164841 0,005402 (35) NM_005520 HNRNPH1 -0,396096 0,005032 Homo sapiens, clone IMAGE:3922927, BC015907 -0,024003 0,005884 mRNA Homo sapiens, clone IMAGE:4703783, BC017428 -0,189778 0,003806 mRNA Homo sapiens, clone IMAGE:5213378, BC039680 -0,111643 0,005158 mRNA Homo sapiens, clone IMAGE:5802033, BC042916 -0,21639 0,007094 mRNA NM_032410 HOOK3 -0,021744 0,004073 NM_000194 HPRT1 0,121062 0,00497 (40) NM_003806 HRK 0,30058 0,005387 NM_153612 HS3ST5 0,153184 0,00452 NM_178135 HSD17B13 0,343624 0,005165 NM_005348 HSP90AA1 0,379638 0,005273 NM_005346 HSPA1B 0,258654 0,005185 NM_001540 HSPB1 0,027114 0,003663 (4*; 47*) NM_006410 HTATIP2 -0,006043 0,004327 NM_002775 HTRA1 -0,37762 0,005345 (7) NM_006417 IFI44 -0,365272 0,005046 (7) NM_001549 IFIT3 -0,522245 0,005186 (32) NM_000874 IFNAR2 -0,103086 0,005539 NM_002176 IFNB1 -0,055154 0,005815 NM_001551 IGBP1 -0,020229 0,002916 NM_000875 IGF1R 0,111028 0,004783 AF058068 IGL@ -0,097259 0,004524 (39) NM_014443 IL17B -0,053551 0,003786 AJ011378 IMAGE:729984 clone, mRNA -0,072219 0,005261 Immunoglobulin heavy chain variable AF103310 region (IGHV1-18 gene), clone A, 0,125893 0,002618 subclone IgM3 NM_000883 IMPDH1 -0,361512 0,005689 (40) NM_006774 INMT 0,084487 0,004511 NM_016133 INSIG2 -0,198057 0,004271 NM_001569 IRAK1 -0,268703 0,004381 NM_002460 IRF4 -0,209786 0,006437 (13) NM_001572 IRF7 -0,174961 0,004019 (32) NM_022334 ITGB1BP1 0,159374 0,004713 NM_004867 ITM2A 0,067909 0,005198 (2; 9; 35) (2; 3; 9; 13; 15; 19; 21; 24; 25; NM_002222 ITPR1 -0,215931 0,005117 30; 35; 48) NM_032801 JAM3 -0,372194 0,002822 NM_006388 KAT5 0,40195 0,005628

NM_031460 KCNK17 0,592982 0,00678 NM_002249 KCNN3 -0,136455 0,005788 NM_172106 KCNQ2 0,289381 0,002052 NM_006801 KDELR1 0,440092 0,004712 BC032361 KIAA0040 0,098736 0,003707 NM_014736 KIAA0101 -0,158202 0,005076 (18; 40) AB051458 KIAA1671 0,126259 0,005855 AB051475 KIAA1688 -0,111541 0,004635 NM_004984 KIF5A -0,410502 0,006319 NM_014512 KIR2DL1 NM_012314 KIR2DS4 -0,448833 0,005442 NM_014513 KIR2DS5 NM_001083539 KIR3DS1 AK055903 KITLG -0,313276 0,005132 D87454 KLHDC10 -0,118165 0,004182 NM_014851 KLHL21 -0,054322 0,005346 NM_004917 KLK4 0,009001 0,004853 NM_007334 KLRD1 0,229224 0,006646 NM_002288 LAIR2 -0,357569 0,006052 BC040653 LAMP2 0,382273 0,009152 NM_052925 LENG8 -0,311815 0,006117 NM_198988 LENG9 NM_002308 LGALS9 -0,0398 0,004657 AF052121 LOC100131510 0,091176 0,003465 XM_001721212 LOC100132526 0,097355 0,003828 BC014063 LOC151878 -0,344775 0,005116 AK055166 LOC154092 -0,413205 0,0047 AK055509 LOC157503 -0,174507 0,003428 BC022493 LOC286002 -0,238507 0,004678 BC008503 LOC642826 -0,161971 0,005367 AK096857 LOC646999 -0,031041 0,007505 BC027871 LOC647323 0,115893 0,005989 AK093957 LOC728264 -0,400499 0,003877 XM_001717165 LOC728361 0,136782 0,005533 NM_032211 LOXL4 0,152099 0,00593 NM_153377 LRIG3 0,243901 0,005738 NM_018214 LRRC1 0,152905 0,003462 NM_006992 LRRC23 0,197064 0,004893 NM_001013626 LRRC67 0,072869 0,00534 NM_181506 LRRC70 -0,307859 0,004289 NM_006309 LRRFIP2 -0,096846 0,005335 NM_024993 LRRTM4 0,10971 0,004898 NM_023946 LYNX1 0,378099 0,003973 NM_130760 MADCAM1 0,220929 0,005865 NM_021048 MAGEA10 -0,176572 0,005706 (33; 40) AK023358 MAGI1 -0,13199 0,004406 H88540 MALAT1 -0,83464 0,004698 (39) NM_020379 MAN1C1 0,026397 0,006008 (12; 21; 37) NM_139021 MAPK15 0,295306 0,004895 NM_005911 MAT2A 0,485263 0,005063 NM_002382 MAX 0,000661 0,005365 (20) NM_016586 MBIP 0,159801 0,004847 (40) NM_021038 MBNL1 -0,029092 0,003117 NM_138799 MBOAT2 0,329152 0,004965 (9) NM_002392 -0,321799 0,004577 (47*) NM_004774 MED1 -0,130449 0,004899 (11)

NM_002397 MEF2C -0,291467 0,004577 NM_020160 MEIS3 -0,017589 0,005868 NR_002211 MEIS3P1 NM_000244 MEN1 0,156291 0,006783 AB062435 MEX3D 0,352257 0,005425 NM_005928 MFGE8 0,317883 0,004672 (9; 11; 13; 15; 17; 25; 42) NM_000247 MICA 0,118138 0,005422 NM_005931 MICB NM_004994 MMP9 -0,423842 0,004309 (4*; 5; 27; 32; 35) NM_058165 MOGAT1 -0,159009 0,006243 D83543 MRNA expressed in skin fibroblasts -0,178352 0,003222 BX537743 MRNA; cDNA DKFZp686E2388 0,411886 0,00363 NM_017840 MRPL16 -0,349223 0,004714 NM_021107 MRPS12 0,019149 0,006788 NM_006800 MSL3 -0,085187 0,00501 (8) NM_020998 MST1 -0,211538 0,004891 NM_004923 MTL5 0,612268 0,001837 BC002770 MTSS1L 0,479495 0,00397 NM_152673 MUC20 0,199789 0,006252 AK056612 MUC21 0,141412 0,005119 NM_014520 MYBBP1A 0,198617 0,006296 NM_000432 MYL2 0,065454 0,005664 (49) NM_000258 MYL3 -0,16316 0,00486 (40) NM_001012643 MYPOP -0,052922 0,004 NM_006766 MYST3 -0,044298 0,00292 NM_003491 NAA10 -0,219347 0,004271 NM_032693 NAA11 NM_000262 NAGA -0,194325 0,005554 NM_004536 NAIP 0,413632 0,005501 BC037350 NAPEPLD 0,059647 0,003372 NM_004851 NAPSA 0,085915 0,006206 NM_004386 NCAN -0,129079 0,005195 AA701554 NCRNA00171 -0,357464 0,006615 NM_006101 NDC80 -0,05522 0,00737 (40) NM_004541 NDUFA1 -0,301276 0,003794 NM_003317 NKX2-1 0,39561 0,006783 (12; 31; 46*) NM_016231 NLK -0,261049 0,005477 (14) AK090439 NLRC5 -0,319826 0,00491 NM_015658 NOC2L 0,004074 0,004872 NM_017617 NOTCH1 -0,4013 0,005144 NM_024408 NOTCH2 0,356555 0,003668 (8) NM_152729 NT5DC1 -0,151605 0,004778 NM_014840 NUAK1 -0,370626 0,004473 NM_016118 NUB1 -0,033032 0,005413 NM_005124 NUP153 0,017471 0,004789 NM_000274 OAT -0,015565 0,004976 (2) NM_182577 ODF3L2 -0,228048 0,005541 NM_001004475 OR10T2 0,316684 0,005322 NM_001005512 OR4A47 0,072076 0,006058 NM_001004755 OR51L1 -0,466263 0,005118 NM_001001954 OR5A2 -0,065627 0,003354 NM_032790 ORAI1 -0,146856 0,005391 NM_001080440 OTOL1 0,28906 0,003137 NM_017670 OTUB1 -0,021812 0,004476 NM_178129 P2RY8 -0,087508 0,005655 AK098692 PACRGL 0,431774 0,00735

NM_002592 PCNA 0,092018 0,003599 (40) NM_006031 PCNT -0,041977 0,001906 NM_002570 PCSK6 0,192107 0,004735 (8) NM_004716 PCSK7 -0,180698 0,005192 NM_024028 PCYOX1L 0,224299 0,00605 NM_025239 PDCD1LG2 -0,101263 0,004809 NM_003681 PDXK -0,024918 0,005583 (40; 42) NM_020315 PDXP 0,197994 0,005382 NM_003847 PEX11A -0,511084 0,004514 NM_001079807 PGA3 NM_001079808 PGA4 0,213471 0,005464 (15) NM_014224 PGA5 NM_000291 PGK1 0,487404 0,005952 (6*; 42) NM_020393 PGLYRP4 -0,359409 0,003038 NM_002651 PI4KB 0,001694 0,004966 NM_002645 PIK3C2A -0,01107 0,004496 NM_003662 PIR 0,012639 0,004823 Placenta mRNA, clone PL45, partial AK026818 -0,074901 0,004224 sequence NM_002656 PLAGL1 -0,170811 0,005533 NM_000933 PLCB4 0,044662 0,00471 (3; 40) NM_015432 PLEKHG4 0,142819 0,004413 NM_000533 PLP1 0,272697 0,001638 (8) NM_017443 POLE3 -0,038475 0,002986 NM_181808 POLN 0,407249 0,004911 NM_022490 POLR1E 0,160185 0,00569 NM_004805 POLR2D 0,20663 0,00486 NM_003660 PPFIA3 -0,097557 0,006034 NM_002705 PPL 0,356172 0,004618 (9; 11) NM_004156 PPP2CB 0,354508 0,003514 (6*; 33) NM_006245 PPP2R5D -0,053612 0,001899 NM_003981 PRC1 -0,006146 0,00627 (33; 40) Primary neuroblastoma cDNA, AL359567 -0,480712 0,003634 clone:Nbla04171, full insert sequence NM_006258 PRKG1 -0,118153 0,005226 NM_005044 PRKX -0,318357 0,004744 (9; 15; 35) U81557 Probable H101 0,488542 0,005199 NM_002770 PRSS1 0,395899 0,005059 (9; 37; 40) NM_007343 PRSS3 XM_001131213 PRSS44 -0,363542 0,003572 NM_002792 PSMA7 -0,003817 0,004467 NM_006263 PSME1 0,148312 0,003922 (22*) AK023948 PTCSC -0,56451 0,006684 (35) NM_000314 PTEN -0,009728 0,005533 (43) NM_012212 PTGR1 0,327784 0,005 NM_014369 PTPN18 -0,306315 0,006246 NM_002830 PTPN4 -0,27401 0,004751 (14) NM_012414 RAB3GAP2 -0,046631 0,003594 NM_005370 RAB8A -0,107902 0,004402 NM_173825 RABL3 0,068154 0,005015 NM_006908 RAC1 -0,80273 0,002368 (33) NM_013277 RACGAP1 -0,272124 0,005129 NM_006105 RAPGEF3 0,25825 0,00499 (42) NM_002888 RARRES1 0,498752 0,007129 (36) NM_016084 RASD1 0,289832 0,005429 NM_032023 RASSF4 -0,114795 0,005711 (21)

NM_006328 RBM14 0,020906 0,006815 NM_031491 RBP5 -0,311303 0,006549 NM_172071 RC3H1 0,026752 0,007095 NM_005822 RCAN2 -0,190976 0,005344 (2; 29) NM_173587 RCOR2 0,163691 0,004824 NM_016026 RDH11 -0,077461 0,005666 NM_002906 RDX 0,067689 0,002771 BC011603 RELA -0,08394 0,003826 NM_032918 RERG -0,119882 0,005518 (36) NM_173362 RFESD 0,346094 0,004872 NM_152869 RGN -0,192646 0,005195 NM_006480 RGS14 -0,031523 0,004917 AB082530 RICTOR -0,035952 0,003807 NM_020639 RIPK4 0,341467 0,003768 (36) NM_002933 RNASE1 0,009478 0,005561 (3; 13; 15) NM_003730 RNASET2 0,35178 0,004674 (40; 42) NM_014372 RNF11 0,455583 0,004108 (40) NM_000997 RPL37 0,592057 0,004328 NM_000970 RPL6 -0,060128 0,004968 NM_001029 RPS26 0,39481 0,005154 NM_001031 RPS28 0,308788 0,00542 NM_001034 RRM2 0,0956 0,004478 (33) NM_016304 RSL24D1 0,115087 0,003155 NM_023004 RTN4R 0,387124 0,005287 NM_032167 RUNDC2A -0,056101 0,005486 BX648280 RUNDC2C NM_004349 RUNX1T1 0,279084 0,004011 AF075460 RYR1 0,379496 0,002915 (2; 9; 15; 19) NM_171999 SALL3 0,030483 0,005211 NM_021818 SAV1 0,235071 0,00423 NM_004866 SCAMP1 -0,176521 0,005859 NM_016240 SCARA3 0,189468 0,006433 (11) NM_005063 SCD 0,412644 0,005538 (35) NM_198081 SCML4 0,21648 0,00507 AJ310896 SCN5A -0,200418 0,006622 NM_005138 SCO2 -0,095405 0,004418 NM_016176 SDF4 0,335184 0,004542 NM_003001 SDHC 0,01495 0,004079 (40) NM_014701 SECISBP2L 0,217279 0,005737 (7; 40) NM_145204 SENP8 0,286098 0,003949 NM_016332 SEPX1 -0,25385 0,005113 NM_006811 SERINC3 0,419123 0,005075 NM_000354 SERPINA7 0,021343 0,005989 NM_004155 SERPINB9 -0,119007 0,006972 NM_032233 SETD3 0,247423 0,004815 NM_004630 SF1 -0,030968 0,003972 NM_003012 SFRP1 0,070264 0,004637 (9; 36) NM_080743 SFRS13B -0,458735 0,002341 NM_006275 SFRS6 0,002622 0,005871 NM_005475 SH2B3 0,252924 0,00644 (8) NM_031469 SH3BGRL2 0,401364 0,004055 (33) NM_004844 SH3BP5 -0,330889 0,00481 (9) NM_031892 SH3KBP1 -0,104686 0,005277 NM_015677 SH3YL1 0,022823 0,005791 AK074067 SHE -0,060846 0,005046

NM_001040455 SIDT2 -0,030876 0,006038 NM_145061 SKA3 0,374669 0,007608 NM_004170 SLC1A1 -0,299815 0,005549 (8; 9; 29; 40) NM_004172 SLC1A3 -0,070783 0,006458 NM_001145290 SLC37A2 0,175728 0,004628 NM_001076785 SLC7A6 0,236709 0,006237 NM_032178 SLC7A6OS NM_006359 SLC9A6 0,278573 0,004907 NM_005902 SMAD3 0,210766 0,003612 NM_022733 SMAP2 -0,25412 0,005088 NM_032560 SMEK1 -0,209697 0,004308 NM_005631 SMO -0,195568 0,004834 (11) NM_004782 SNAP29 0,153242 0,004327 NM_006049 SNAPC5 0,158904 0,005511 NM_000345 SNCA 0,133992 0,00581 BM926530 SNHG8 0,22355 0,004726 NM_018968 SNTG2 0,554954 0,00374 (46*) NM_001080530 SNX29 -0,156722 0,005622 NM_013321 SNX8 0,375322 0,004995 NM_000346 SOX9 0,343214 0,005269 (40) NM_004509 SP110 -0,224314 0,005136 (17) NM_181727 SPATA12 -0,182819 0,004072 NM_144722 SPEF2 -0,326546 0,003634 NM_003120 SPI1 0,382034 0,002979 NM_182538 SPNS3 -0,168573 0,007252 NM_173080 SPRR4 0,246882 0,004062 NM_025106 SPSB1 -0,006486 0,004772 NM_182692 SRPK2 0,308918 0,007189 NM_003145 SSR2 0,213802 0,004454 BX537506 ST3GAL1 0,380788 0,004878 NM_018234 STEAP3 0,254199 0,005029 (29; 37) NM_005990 STK10 0,036865 0,005842 NM_004760 STK17A 0,078138 0,001876 NM_005563 STMN1 0,357338 0,005466 (33; 40) NM_017919 STX17 -0,279553 0,003217 NM_018837 SULF2 -0,347076 0,004957 NM_000456 SUOX -0,257671 0,005186 NM_007192 SUPT16H -0,103145 0,005748 NM_018373 SYNJ2BP -0,103827 0,005786 (40) NM_032431 SYVN1 0,012023 0,007049 NM_014409 TAF5L -0,015912 0,002744 NM_001003806 TARP -0,270845 0,005028 NM_017714 TASP1 0,03844 0,004692 NM_017752 TBC1D8B -0,164371 0,004951 AK022764 tcag7.1196 -0,141504 0,002425 AA689513 TCL1B -0,752388 0,004669 NM_018319 TDP1 0,300164 0,003 BG701637 TDRG1 -0,308654 0,005559 NM_138501 TECR 0,258748 0,005585 (15; 16) NM_018975 TERF2IP 0,236576 0,00527 NM_005782 THOC4 0,241235 0,005452 NM_025075 THOC7 0,023123 0,006784 NM_003249 THOP1 0,027973 0,003943 (40) NM_004817 TJP2 0,186998 0,004933 NM_016170 TLX2 0,215995 0,004941

NM_007024 TMEM115 -0,063841 0,005406 NM_174909 TMEM167A -0,132621 0,005237 NM_001142645 TMEM194B -0,274463 0,003765 NM_052913 TMEM200A 0,159579 0,007377 (39) NM_001136534 TMEM233 -0,132484 0,005832 NM_145274 TMEM99 -0,014731 0,006033 NM_014058 TMPRSS11E 0,365504 0,004534 NM_012452 TNFRSF13B 0,112116 0,004896 NM_003838 TNNI3K -0,273815 0,004591 NM_032174 TOMM40L 0,126583 0,005031 AJ011007 TOMM7 0,242901 0,00477 NM_001067 TOP2A 0,227589 0,003933 (17; 18; 39; 40) NM_032883 TOX2 0,087395 0,005729 NM_000546 TP53 0,179195 0,005488 (43; 46*; 47*) NM_005426 TP53BP2 0,182763 0,004807 NM_021138 TRAF2 -0,147306 0,002241 NM_006700 TRAFD1 -0,160257 0,00514 AL713660 Transcribed -0,320177 0,005325 AL050145 Transcribed locus -0,279907 0,003797 AL832729 Transcribed locus -0,253314 0,005054 AL833286 Transcribed locus 0,131036 0,006527 NM_016388 TRAT1 0,212178 0,00516 NM_016213 TRIP4 0,04132 0,002232 NM_004621 TRPC6 -0,065959 0,004798 (14; 20) NM_001100917 TSPAN19 0,059521 0,002463 NM_006675 TSPAN9 -0,002614 0,004616 NM_022117 TSPYL2 -0,203346 0,003659 NM_032538 TTBK1 0,206232 0,006109 NM_004623 TTC4 0,321765 0,0044 NM_173810 TTC9C -0,063014 0,004052 NM_024331 TTPAL 0,16249 0,004205 AF332242 TTTY13 0,436983 0,002313 NM_006009 TUBA1A NM_006082 TUBA1B 0,262328 0,004713 (33; 40) NM_032704 TUBA1C NM_006765 TUSC3 0,208943 0,004975 (2; 9; 18; 24; 25; 26; 35; 40) NM_018961 UBASH3A -0,146621 0,00302 NM_006357 UBE2E3 0,384821 0,004986 NM_014517 UBP1 -0,22618 0,005024 AB011111 URB1 -0,049573 0,00491 NM_032747 USMG5 0,373187 0,002512 NM_017414 USP18 0,193769 0,004375 NM_018289 VPS53 0,038948 0,00331 NM_000377 WAS 0,39542 0,003837 NM_012477 WBP1 0,289459 0,006044 BC035289 WDR27 -0,358137 0,004565 NM_018268 WDR41 -0,229111 0,005732 NM_147198 WFDC9 0,237382 0,005841 NM_006005 WFS1 -0,108735 0,00399 (9; 40; 42) NM_006648 WNK2 0,27195 0,005292 NM_015626 WSB1 -0,829931 0,005693 NM_003405 YWHAH 0,088217 0,007138 (17; 40) AL050155 ZC3H4 -0,018911 0,003998 NM_024721 ZFHX4 -0,147594 0,004947 (11; 49) NM_024645 ZMAT4 -0,159808 0,004983 (17; 37; 42)

NM_080740 ZNF280A -0,267226 0,00513 NM_022095 ZNF335 0,165858 0,003748 NM_018083 ZNF358 -0,278137 0,005389 NM_025189 ZNF430 0,027995 0,004886 AK095317 ZNF518A -0,285678 0,004752 NM_007131 ZNF75D -0,30543 0,004125 NM_145062 ZUFSP 0,20836 0,005452 XM_001724136 Not in a UniGene Hs cluster -0,132384 0,005346 NM_018572 Not in a UniGene Hs cluster -0,362949 0,003983 NM_152500 Not in a UniGene Hs cluster -0,328207 0,003613 XM_353280 Not in a UniGene Hs cluster -0,240067 0,003908 XM_351191 Not in a UniGene Hs cluster -0,235276 0,005297 XM_353385 Not in a UniGene Hs cluster -0,205404 0,00443 XM_352830 Not in a UniGene Hs cluster -0,19469 0,005645 NM_024633 Not in a UniGene Hs cluster -0,145634 0,005099 L12079 Not in a UniGene Hs cluster -0,134114 0,003975 NM_173651 Not in a UniGene Hs cluster -0,128188 0,003736 XM_167232 Not in a UniGene Hs cluster -0,086701 0,00285 AF064510 Not in a UniGene Hs cluster -0,076151 0,005127 AK023050 Not in a UniGene Hs cluster -0,072805 0,005866 AL137761 Not in a UniGene Hs cluster -0,043103 0,004122 XM_001718373 Not in a UniGene Hs cluster -0,033261 0,00511 AF030493 Not in a UniGene Hs cluster 0,059751 0,002835 AF063717 Not in a UniGene Hs cluster 0,20723 0,002891 AF202635 Not in a UniGene Hs cluster 0,065255 0,006833 BC004476 Not in a UniGene Hs cluster 0,42396 0,005297 BC014212 Not in a UniGene Hs cluster 0,651205 0,004878 NM_018579 Not in a UniGene Hs cluster 0,215027 0,004702 NM_032161 Not in a UniGene Hs cluster -0,001081 0,006081 NM_032886 Not in a UniGene Hs cluster 0,04481 0,00558 NM_152461 Not in a UniGene Hs cluster 0,288891 0,002945 NM_182564 Not in a UniGene Hs cluster 0,306599 0,00457 XM_291903 Not in a UniGene Hs cluster 0,330968 0,00467 XM_350903 Not in a UniGene Hs cluster 0,244926 0,010321 XM_352896 Not in a UniGene Hs cluster 0,256559 0,003872 XM_352945 Not in a UniGene Hs cluster 0,529439 0,005043 XM_353008 Not in a UniGene Hs cluster 0,109253 0,004632 XM_353093 Not in a UniGene Hs cluster 0,173955 0,006026 XM_353101 Not in a UniGene Hs cluster 0,731264 0,005081 XM_353513 Not in a UniGene Hs cluster 0,138407 0,006548 Unknown Probe hybridizes with 0,197926 0,005233 Unknown Probe hybridizes with chromosome 1 0,359641 0,004655 Unknown Probe hybridizes with chromosome 12 0,008452 0,00606 Unknown Probe hybridizes with chromosome 14 0,33193 0,004153 Unknown Probe hybridizes with chromosome 17 0,204607 0,003493 Unknown Probe hybridizes with -0,062589 0,005723 Unknown Probe hybridizes with 0,135327 0,003875 Unknown Probe hybridizes with chromosome 22 -0,049732 0,00281 Unknown Probe hybridizes with chromosome 3 -0,108745 0,003368 Unknown Probe hybridizes with chromosome 6 0,002228 0,005275 Unknown Probe hybridizes with chromosome 6 0,26391 0,004464

References 1* Achille, M., H. Boukheris, et al. (2009). "Expression of cell cycle biomarkers and telomere length in papillary thyroid carcinoma: a comparative study between radiation-associated and spontaneous cancers." Am J Clin Oncol 32(1): 1-8. 2 Aldred, M. A., Y. Huang, et al. (2004). "Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes." J Clin Oncol 22(17): 3531-9. 3 Barden, C. B., K. W. Shister, et al. (2003). "Classification of follicular thyroid tumors by molecular signature: results of gene profiling." Clin Cancer Res 9(5): 1792-800. 4* Boltze, C., A. Riecke, et al. (2009). "Sporadic and radiation-associated papillary thyroid cancers can be distinguished using routine immunohistochemistry." Oncol Rep 22(3): 459-67. 5 Borrello, M. G., L. Alberti, et al. (2005). "Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene." Proc Natl Acad Sci U S A 102(41): 14825-30. 6* Brown, L. M., S. M. Helmke, et al. (2006). "Quantitative and qualitative differences in protein expression between papillary thyroid carcinoma and normal thyroid tissue." Mol Carcinog 45(8): 613-26. 7 Cahill, S., P. Smyth, et al. (2006). "Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model." Mol Cancer 5: 70. 8 Chevillard, S., N. Ugolin, et al. (2004). "Gene expression profiling of differentiated thyroid neoplasms: diagnostic and clinical implications." Clin Cancer Res 10(19): 6586-97. 9 Delys, L., V. Detours, et al. (2007). "Gene expression and the biological phenotype of papillary thyroid carcinomas." Oncogene 26(57): 7894-903. 10 Denning, K. M., P. C. Smyth, et al. (2007). "A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples." Mod Pathol 20(10): 1095-102. 11 Detours, V., L. 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