Actin ● to both and this other ● MreB is an analogue to this protein ● formins facilitate processive assembly of these at their barbed ends ● long chains that consist of this protein reach a steady state condition known as treadmilling ● binding of ATP to causes the myosin to release its grip on this protein ● listeria has a surface protein that promotes assembly of this protein ● proteins such as and CapZ prevent this protein from treadmilling ● cytochalasins and phalloidin are toxins that work by binding to this protein ● comes in filamentous "F" polymers and globular "G" monomers ● binds and inactivates DNase ● bundles of this protein facilitate the formation of structures like filopodia ● branching of this protein is stimulated by WASp proteins ● promotes its polymerization ● binds to on the cytoplasmic side of adherens junctions ● nematode sperm lack it

Hemoglobin ● Barts form­ found in people with hydrops fetalis ● hill coefficient of about 2.8 ● hydroxyurea increases concentration of its F form

Keratin ● produced in cornification ● makes up most intermediate filaments

Collagen ● stained blue in Masson's trichrome stain ● glycine­proline­hydroxyproline ● mutations in the for it­ chrom 2­ Alport syndrome­ basket weave kidneys ● crystalline form­ eye lens ● Dupuytren's contracture­ Xiaflex ● Ehler­Danlos syndrome­ error in its production ● cortisol stimulates its breakdown ● associated with it­ linked to Caffey's disease (infantile cortical hyperostosis) ● affected in Peyronie’s disease­makes yo dick bent (has yet to come up in a tossup)

Carbonic Anhydrase ● active site contains three histidine residues ● central zinc atom ● drugs like acetazolamide and Dorzolamide inhibits it to treat glaucoma

DNA polymerase ● one can be cleaved by subtilisin to form a Klenow fragment ● used with a nuclease in Nick translation ● Arthur Kornberg discovered the first one of them ● used in Sanger sequencing ● two "bypass" ones are created in SOS response ● one of them associates with the "sliding clamp" myoglobin ● 1962 Nobel in Chem ● Malignant hyperthermia and McArdle's disease cause it to be present in urine ● found in high concentration in the muscles of deep diving mammals (seals, whales, etc.) ● extracted from horse hearts oxygenases (protein class) ● convert arachidonic acid to an eicosanoid ● most cytochrome P450 enzymes belong to this class ● RuBisCO acts as one instead of a carboxylase in photorespiration ● abundant one in humans­CYP3A4

Reverse transcriptase ● form of this enzyme is named for its involvement in Moloney murine leukemia ● names a catalytic subunit of telomerase that adds nucleotides in TTAGGG fashion to the end of telomeres ● with integrase and protease, this enzyme is encoded by the pol gene ● Northern blot has largely been replaced with either a one­ or two­step variant of PCR involving this enzyme ● AZT inhibits the activity of this enzyme ● belongs to the RNase H family

Proteasome ● ubiquitin binding signals for degradation by it ● inhibited by lactacystin ● inhibited by ritonavir ● 11S, 19S, 20S subunits

Telomerase ● targeted by GRN163L ● the ALT pathway acts as a loophole around inhibitors of this protein ● gene that codes for it is deleted in cri du chat ● its activity is measured using PCR in the TRAP assay ● Its substrate’s accessibility is controlled by shelterin complex ○ TIN2, TRF1, TRF2, POT1, RAP1, and TPP1 are its components ● composed of TERT, TERC, and DKC1 ● in its absence, cells eventually reach their Hayflick limit ● discovered by Greider and Blackburn in Tetrahymena ● adds TTAGGG sequence repeats