PFDN5, MM1, PFD5, Prefoldin Subunit 5, C- Myc-Binding Protein Mm-1, Myc Modulator 1) (Biotin)

PFDN5, ID (PFDN5, MM1, PFD5, Prefoldin subunit 5, C- Myc-binding protein Mm-1, Myc modulator 1) (Biotin)

Catalog number 039900-Biotin Supplier United States Biological

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]. Applications Suitable for use in Western Blot, Immunohistochemistry, ELISA Recommended Dilution ELISA: 1:1,000 Western Blot: 1:100-500 Immunohistochemistry: 1:10-50 Storage and Stability Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note Applications are based on unconjugated antibody. Immunogen KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 79-108 in the central region of human PFDN5, UniProt Accession #NP_002615.2; Q99471. Species sequence homology: bovine Formulation Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin. Purity Purified by Protein A affinity chromatography. Specificity Recognizes human PFDN5. Species Crossreactivity: mouse Product Type Pab Source human Isotype IgG Grade Affinity Purified Applications E IHC WB Crossreactivity Hu Mo Storage -20°C Detection Method Biotin Reference 1. Ma, H.C., et al. J. Biomed. Sci. 15(4):417-425(2008) 2. Yoshida, T., et al. Exp. Cell Res. 314(6):1217-1228(2008) 3. Lubyova, B., et al. J. Biol. Chem. 282(44):31944-31953(2007) 4. Hagio, Y., et al. J. Cell. Biochem. 97(1):145-155(2006) 5. Bruneel, A., et al. Proteomics 5(15):3876-3884(2005)