CancerResearch VOLUME 50 •NUMBER17 •CNREA8•PP5211-5605

CONTENTS§

Asterisks * preceding page numbers refer to studies using human-derived material.

Editorial 5275 Intracellular DNA Strand Scission and Growth Inhibition of 5211 Advances in Brief. Carlo M. Croce. Editor-in-Chief. Ehrlich Ascites Tumor Cells by Bleomycins. Robert W. Byrnes, Jeffrey Templin. Daniel Sem, Suzanne Lyman, and David H. Petering. * 5287 Augmentation of Cytotoxic Effect of Tumor Necrosis Factor on Human Immunodeficiency Virus-infected Cells by Staurosporine, *5212 Activity of the Thymidylate Synthase Inhibitor 2-Desamino-Ari°- a Potent Protein Kinase C Inhibitor. Yoshiaki Hamamoto, propargyl-5,8-dideazafolic Acid and Related Compounds in Mu Toshifumi Matsuyama, Naoki Yamamoto, and Nobuyuki rine (L1210) and Human (W1L2) Systems in Vitro and in L1210 Kobayashi. in Vivo. Ann L. Jackman. Gordon A. Taylor, Brigid M. O'Connor, Joel A. Bishop. Richard G. Moran, and A. Hilary *52'M Regulation of Progesterone Receptor Gene Expression. Calvert. E. Vegeto, M. G. Cocciolo, F. Raspagliesi, A. Piffanelli, R. Fontanelli, and A. Maggi. 5219 Induction of Cytochrome P-450 and 5-Aminolevulinate Synthase 5296 Failure of Chronic Glutathione Elevation to Reduce Cytotoxicity Activities in Cultured Rat Hepatocytes. Peter R. Sinclair. William Produced by Exposure to ci's-Diamminedichloroplatinum(II), J. Bernent. Sally A. Haugen, Jacqueline F. Sinclair, and Philip S. Ionizing Radiation, or Hyperthermia. Michael L. Freeman, Guzelian. Michael J. Meredith, and Donald R. Eisert. * 5225 Tumor Localization by Combinations of Monoclonal Antibodies 5301 2-Acetylaminofluorene-mediated Alteration in the Level of Liver in a New Human Colon Carcinoma Cell Line (LIM1899). Sarah ArylsulfotransferaseIV duringRat Hepatocarcinogenesis. David P. M. Andrew, Jin Ghee Teh. Ricky W. Johnstone. Sarah M. Ringer, Tom R. Norton, and Boyd A. Howell. Russell, Robert H. Whitehead, Ian F. C. McKenzie, and Geoffrey A. 5308 Attenuating Effect of Bromocriptine on Cysteamine Anticar- Pietersz. cinogenesis of Stomach Cancers Induced by /V-Methyl-jV'- *5231 Smoking and Renal Cell Carcinoma. Carlo La Vecchia, Eva nitro-TV-nitrosoguanidine.Masaharu Tatsuta, Hiroyasu lishi, Negri, Barbara D'Avanzo, and Silvia Franceschi. Miyako Baba, Makoto Ichii, Akihiko Nakaizumi, Hiroyuki Uehara. and Haruo Taniguchi. *5234 Augmentation of Antibody Dependent Cell Mediated Cytotoxicity following in Vivo Therapy with Recombinant Interleukin 2. * 5312 Abnormalities in Structure and Expression of the Retinoblastoma Jacquelyn A. Hank, Randy R. Robinson, Jean Surfus, Barbara Gene in Small Cell Lung Cancer Cell Lines and Xenografts in M. Mueller, Ralph A. Reisfeld, Nai-Kong Cheung, and Paul M. Nude Mice. KáreRygaard, George D. Sorenson, Olive S. Pettengill. Charles C. Cate, and Mogens Spang-Thomsen. Sondel. * 52-10 Detection of Minimal Residual Disease in Leukemic Patients 5318 Application of a New Approach for the Quantitation of Drug Syn- ergism to the Combination of c/s-Diamminedichloroplatinum and with the t(10;14)(q24;qll) Chromosomal Translocation. Jacob l-i8-D-Arabinofuranosylcytosine. William R. Greco, Hyoung Kagan, Lawrence R. Finger, Emanuel Besa, and Carlo M. Croce. Sook Park, and Youcef M. Rustum. 5245 DNA Fingerprinting of 7,12-Dimethylbenz(a|anthracene-induced * 5328 a-Interferon Structure and Natural Killer Cell Stimulatory Activ and Spontaneous CD-I Mouse Liver Tumors. Brian J. Ledwith, ity. Bo-Liang Li, Xiao-Xia Zhao. Xin-Yuan Liu, Hyon Suk Kim, Richard D. Storer. Srinivasa Prahalada, Sujata Manam, Karen R. Karel Raska, Jr., John R. Ortaldo, Barbara Schwartz, and Sidney Leander, Matthew J. van Zwieten, Warren W. Nichols, and Pestka. Matthews O. Bradley. 5333 Role of P450IIE1 in the Metabolism of 3-Hydroxypyridine, a 5250 Effect of Tunicamycin on Sialomucin and Natural Killer Suscep Constituent of Tobacco Smoke: Redox Cycling and DNA Strand tibility of Rat Mammary Tumor Ascites Cells. Seema Bharathan, Scission by the Metabolite 2,5-Dihydroxypyridine. Sang Geon John Moriarty, Charles E. Moody, and Anne P. Sherblom. Kim and Raymond F. Novak.

* 5257 Effect of Guanine and Adenine Nucleotides on Bombesin-stimu- 5340 Substrate Specificity of the Exonuclease Associated with Calf DNA Polymerase i. Ralph D. Sabatino, Thomas W. Myers, and lated Phospholipase C Activity in Membranes from Swiss 3T3 Robert A. Bambara. and Small Cell Lung Carcinoma Cells. Yoav Sharoni. Jean Viallet, Jane B. Trepel. and Edward A. Sausville. *5345 Carbohydrate Analysis of Immunoglobulin G Myeloma Proteins by Lectin and High Performance LiquidChromatography:Role of *5263 Clonal Analysis of Lymphocytes from Tumor, Peripheral Blood, Glycosyltransferases in the Structures. Tetsuo Nishiura, Shigeru and Nontumorous Kidney in Primary Renal Cell Carcinoma. Fujii, Yoshio Kanayama, Atsushi Nishikawa, Yoshiaki Tae-Yoon Kim, Andrew C. von Eschenbach. MaryLynne D. Tomiyama, Masato lida, Takahiro Karasuno, Hirohisa Nakao, Filaccio. Kazuhiro Hayakawa, David R. Parkinson. Charles M. Takeshi Yonezawa, Naoyuki Taniguchi, and Seiichiro Tarui. Balch, and Kyogo Itoh. 5351 Role of Growth Factor Synthesis in the Acquisition of Insulin/ 5269 Tiazofurin Is Phosphorylated by Three Enzymes from Chinese Insulin-like Growth Factor I Independence in Rat Mammary Car Hamster Ovary Cells. Priscilla P. Saunders, Christy D. Spindler, cinomaCells. Stephen P. Ethier.CaterinaChiodino, and RichardF. Mei-Tao Tan. Esperanza Alvarez, and Roland K. Robins. Jones. §TheCONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

Downloaded from cancerres.aacrjournals.org on September 25, 2021. © 1990 American Association for Cancer Research. Suppressor Cell Activity in a Randomized Trial of Patients Re 5453 Evaluation of Cysteine Adduct Formation in Rat Hemoglobin by ceiving Active Specific Immunotherapywith Melanoma Cell Vac 4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone and Related cine and Low Dosages of Cyclophosphamide. Dave S. B. Hoon. Compounds. Steven G. Cannella, Shashi S. Kagan, Thomas E. Leland J. Foshag, Anne S. Nizze, Roger Bohman, and Donald L. Spratt, and Stephen S. Hecht. Morton. 5460 Potentiation of Natural Killer Cell Activity and Tumor Immunity PorphyrinPhotosensitivity in Cell Lines Expressing a Heat-resist 5365 by Diacetylputrescine. Terry L. Bowlin, Andrea Rosenberger, ant Phenotype. Charles J. Gomer, Natalie Rucker, and Sam David Stemerick, and Michael L. Edwards. Wong. 5464 Aristolochic Acid Activates ras Genes in Rat Tumors at Deoxy- * 5369 PhotosensitizingDyes for the Selection of NontumorigenicRevert- ants from Human Lung Cancer Cell Lines. Josh W. McDonald, adenosine Residues. Heinz H. Schmeiser, Johannes W. G. Douglas E. Brash, Allan R. OserofF, and Curtis C. Harris. Janssen, John Lyons, Hans R. Scherf, Wolfgang Pfau, Albrecht Buchmann, Claus R. Bartram, and Manfred Wiessler. 5374 Identification of Ultraviolet-inducible Proteins That Bind to a TGACAACA Sequence in the Polyoma Virus Regulatory Region. * 5470 Ecological Correlation between Arsenic Level in Well Water and Zeev A. Ronai and I. BernardWeinstein. Age-adjusted Mortality from Malignant Neoplasms. Chien-Jen *5382 Chen and Chin-Jen Wang. Androgen Receptor Gene Expression in Human Prostate Car cinoma Cell Lines. W. D. Tilley. C. M. Wilson, M. Marcelli. and 5475 Prevention of Central Nervous System Toxicity of the Antitumor M. J. McPhaul. Antibiotic Acivicin by Concomitant Infusion of an Amino Mix !':5387 Effect of a-Interferon, 17/3-Estradiol,and Tamoxifen on Estrogen ture. Marta G. Williams, Robert H. Earhart, Howard Bailey, and Receptor Concentrationand Cell Cycle Kinetics of MCF 7 Cells. J. Patrick McGovren. W. R. Bezwoda and K. Meyer. *5481 Peripheral Airway Cell Differentiation in Human Lung Cancer *5392 Non-P-Glycoprotein Mediated Multidrug Resistance Precedes Cell Lines. Adi F. Gazdar, R. Ilona Linnoila, Yukio Kurita, P-Glycoprotein Expression during in Vitro Selection for Dox- Herbert K. Oie, James L. Mulshine, Jean C. Clark, and Jeffrey A. orubicin Resistance in a Human Lung Cancer Cell Line. F. Baas. Whitsett. A. P. M. Jongsma, H. J. Broxterman, R. J. Arceci, D. Housman, G. L. Scheffer. A. Riethorst, M. van Groenigen, A. W. M. * 5488 Establishment and Characterization of a Human Adrenocortical Nieuwint. and H. Joenje. Carcinoma Cell Line That Expresses Multiple Pathways of Ster !'Õ5399 Inhibition of Human Breast Cancer Cell Proliferation in Tissue oid Biosynthesis. Adi F. Gazdar, Herbert K. Oie, Cedric H. Culture by the Neuroleptic Agents Pimozide and Thioridazine. Shackleton, T. R. Chen, Timothy J. Triche, Charles E. Myers, Jeannine S. Strobl, Keith L. Kirkwood, Tracy K. Lantz. Michael George P. Chrousos. Murray F. Brennan, C. A. Stein, and Renato A. Lewine. Virginia A. Peterson, and Jennings F. Worley III. V. La Rocca. :*:5406 A Deletion Linked to a Poly(ADP-ribose) Polymerase Gene on ÃŽ"C5497Gangliosides and Sialoglycoproteins Carrying a Rare Blood Chromosome 13q33-qter Occurs Frequently in the Normal Black Group Antigen Deeerminant, Cad, Associated with Human Can Population as Well as in Multiple Tumor DNA. Kishor G. cers as Detected by Specific Monoclonal Antibodies. Nozomu Bhatia, Barry W. Cherney, Konrad Huppi, Ian T. Magrath, Hiraiwa. Kiyotaka Tsuyuoka. Yu-Teh Li, Mitunobu Tanaka, Jeffrey Cossman, Edward Sausville. Francisco Barriga, Bruce Taiko Seno. Yasuto Okubo, Yoshihiro Fukuda, Hiroo Imura, Johnson, Barry Gause, George Bonney, Janet Neequayi, Maria and Reiji Kannagi. DeBernardi, and Mark Smulson. *5414 Antitumor Effects of a-Interferon and -y-Interferonon a Murine 5504 Cytotoxicity Phase of Diethylnitrosamine-induced Hepatic Neo Renal Cancer (Renca) in Vitro and in Vivo. T. J. Sayers, T. A. plasia in Medaka. Darrel J. Lauren, Swee J. Teh, and David E. Wiltrout. K. McCormick, C. Husted, and R. H. Wiltrout. Hinton. 5515 Assessment of Protein Kinase C Isozymes by Enzyme Iinmu- 5421 Monoclonal Antibody Therapy of Murine Lymphoma: Enhanced Efficacy by Concurrent Administration of Interleukin 2 or Lym- noassay and Overexpression of Type II in Thyroid Adenocar- phokine-activated Killer Cells. Kirk R. Schultz. Jay P. Klarnet. cinoma. Masatoshi Hagiwara, Takahisa Hachiya, Masato David J. Peace. Martin A. Cheever. Christopher C. Badger. Irwin Watanabe, Nobuteru Usuda, Futoshi lida, Katsuyuki Tamai, and D. Bernstein, and Philip D. Greenberg. Hiroyoshi Hidaka. * 5520 Differentiation and Growth Modulation of Chronic Myelogenous 5426 Modulation of 06-Methylguanine-DNA Methyltransferase in Rat and Hamster Liver after Treatment with Dimethylnitrosamine. Leukemia Cells by Bryostatin. Michael Lilly. Chris Tompkins, Janet Hall. Henriette Brésil,Mireille Serres, Ghyslaine Martel- Chris Brown, George Pettit, and Andrew Kraft. Planche, Christopher P. Wild, and Ruggero Montesano. 5526 Establishment and Characterization of a Tumorigenic Murine Vascular Endothelial Cell Line (F-2). Ken-Ichi Toda. Kaoni Cloning and Characterization of Human Tumor Cell Interstitial Tsujioka, Yukiya Maruguchi. Kazuhiro Ishii, Yoshiki Miyachi, Collagenase. Nancy Smyth Templeton. Peter D. Brown. Anna T. Kagemasa Kuribayashi, and Sadao Imamura. Levy, Inger M. K. Margulies. Lance A. Liotta, and William G. Stetler-Stevenson. * 5531 Establishment and Characterization of Human Renal Cancer and Normal Kidney Cell Lines. T. Ebert, N. H. Bander, C. L. Finstad, *5438 Mass Spectrometric Analysis of Tobacco-specific Nitrosamine R. D. Ramsawak, and L. J. Old. Hemoglobin Adducts in Snuff Dippers, Smokers, and Non- smokers. Steven G. Cannella, Shashi S. Kagan, Mark Kagan, 5537 Role of Tumor Necrosis Factor in Flavone Acetic Acid-induced Peter G. Foiles, George Palladino, Arthur M. Quart, Elaine Tumor Vasculature Shutdown. Viswanath Mahadevan, Saleem T. Quart, and Stephen S. Hecht. A. Malik, Anthony Meager, Walter Fiers, Graham P. Lewis, and Ian R. Hart. 5446 Dose-Response Study of DNA and Hemoglobin Adduct Forma tion by 4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone in F344 5543 In Vivo Administration of Interferon a and Interleukin 2 Induces Rats. Sharon E. Murphy. Adrienne Palomino. Stephen S. Hecht, Proliferation of Lymphoid Cells in the Organs of Mice. Raj K. and Dietrich Hoffmann. Puri. William D. Travis, and Steven A. Rosenberg.

Downloaded from cancerres.aacrjournals.org on September 25, 2021. © 1990 American Association for Cancer Research. *5551 In Vivo Interleukin 2-induced Activation of Lymphokine-acti- 5581 Selection for Spontaneous Metastasis after Calcium Phosphate- vated Killer Cells and Tumor Cytotoxic T-Cells in Cervical mediated Transfer of DNA. Ruth J. Muschel. Lymph Nodes of Patients with Head and Neck Tumors. Licia Rivellini, Carlo Gambacorti-Passerini, Massimo Squadrelli- *5587 MalignantTransformationof Human Fibroblastsby a Trans- fectedN-rasOncogene.Daniel M. Wilson,DajunYang,John E. Saraceno, Maria Ilaria Grosso, Giulio Cantù, Roberto Molinari, Attilio Orazi. and Giorgio Parmiani. Dillberger. Stephen E. Dietrich, Veronica M. Mäher,and J. Justin McCormick. * 5558 EnhancementofRicinA ChainImmunotoxinActivityby Perhex- iline on Established and Fresh Leukemic Cells. Jean-Pierre Jaffrézou.Thierry Levade. Emilienne Kuhlein, Olivier Thurneyssen, Marielle Chiron, HélèneGrandjean,Dominique Carrière,andGuy Laurent. 5594 Announcements 5567 Effect of 12-0-Tetradecanoylphorbol-13-acetate on Colony For mation and Intercellular Communication in a ( '»cultureSystem of Eighty-secondAnnual Meetingof the AACR Call for Nominations for the ScientificAwardsof the AACR JB6 Clones. Ichiro Yamadori, Ursula I. Heine. Susan Kenney. AACR SpecialConferences in Cancer Research Charles W. Riggs, and Jerry M. Rice. Future Annual Meetingsof the AACR 5574 Combined Histochemical and Biochemical Analysis of Sex Hor Recent Death mone Dependence of Ferric Nitrilotriacetate-induced Renal Lipid Calendar of Events Peroxidation in ddY Mice. Shinya Toyokuni, Shigeru Okada, 5596 Employment Register of the AACR Shuji Hamazaki, Yukiko Minamiyama, Yoshihiro Yamada, Ping Liang, Yasutomo Fukunaga, and Osamu Midorikawa. 5604 Author Index

NOTE: AACR forms available in the back of this issue— •Application for Active and Corresponding Membership •Application for Associate Membership

Downloaded from cancerres.aacrjournals.org on September 25, 2021. © 1990 American Association for Cancer Research. Cancer Research

VOLUME 50 •NUMBER 17

CONTENTS Arranged by Subject Category

Editorial *5438 Mass Spectrometric Analysis of Tobacco-specific Nitrosamine Hemoglobin Adducts in Snuff Dippers, Smokers, and Non- 5211 Advances in Brief. Carlo M. Croce, Editor-in-Chief. smokers. Steven G. Cannella, Shashi S. Kagan, Mark Kagan, Peter G. Foiles, George Palladino, Arthur M. Quart, Elaine Quart, and Stephen S. Hecht. 5446 Dose-Response Study of DNA and Hemoglobin Adduct Forma BASIC SCIENCES tion by 4-(Mothylnitrosamini))-l-(3-pyridyl)-I-bulanom> in F344 Rats. Sharon E. Murphy, Adrienne Palomino, Stephen S. Hecht, Biochemistry and Biophysics and Dietrich Hoffmann. 5219 Induction of Cytochrome 1' 450 and 5-Aminolevulinate Synthase 5453 Evaluation of Cysteine Adduct Formation in Rat Hemoglobin by Activities in Cultured Rat Hepatocytes. Peter R. Sinclair, William 4-(Methylnitrosamino)-l-(3-pyridyl)-l-butanone and Related J. Bernent, Sally A. Haugen, Jacqueline F. Sinclair, and Philip S. Compounds. Steven G. Cannella, Shashi S. Kagan, Thomas E. Guzelian. Spratt. and Stephen S. Hecht. 5250 Effect of Tunicamycin on Sialomucin and Natural Killer Suscep 5464 Aristolochic Acid Activates ras Genes in Rat Tumors at Deoxy- tibility of Rat Mammary Tumor Ascites Cells. Seema Bharathan. adenosine Residues. Heinz H. Schmeiser, Johannes W. G. John Moriarty. Charles E. Moody, and Anne P. Sherblom. Janssen. John Lyons, Hans R. Scherf, Wolfgang Pfau. Albrecht *5257 Effect of Guanine and Adenine Nucleotides on Bombesin-stimu- Buchmann. Claus R. Bartram, and Manfred Wiessler. lated Phospholipase C Activity in Membranes from Swiss 3T3 5504 Cytotoxicity Phase of Diethylnitrosamine-induced Hepatic Neo and Small Cell Lung Carcinoma Cells. Yoav Sharoni. Jean plasia in Medaka. Darrel J. Lauren, Swee J. Teh, and David E. Viallet. Jane B. Trepel. and Edward A. Sausville. Hinton. 5269 Tiazofurin Is Phosphor) lated by Three Enzymes from Chinese 5567 Effect of 12-O-Tetradecanoylphorbol-13-acetate on Colony For Hamster Ovary Cells. Priscilla P. Saunders. Christy D. Spindler. mation and IntercellularCommunicationin a Coculture System of Mei-Tao Tan. Esperanza Alvarez, and Roland K. Robins. JB6 Clones. Ichiro Yamadori, Ursula 1. Heine. Susan Kenney, 5275 Intracellular DNA Strand Scission and Growth Inhibition of Charles W. Riggs. and Jerry M. Rice. Ehrlich Ascites Tumor Cells by Bleomycins. Robert W. Byrnes, 5574 Combined Histochemical and Biochemical Analysis of Sex Hor Jeffrey Templin, Daniel Sem, Suzanne Lyman. and David H. mone Dependence of Ferric Nitrilotriacetate-induced Renal Lipid Petering. Peroxidation in ddY Mice. Shinya Toyokuni, Shigeru Okada, *5328 cr-InterferonStructure and Natural Killer Cell Stimulatory Activ Shuji Hamazaki, Yukiko Minamiyama, Yoshihiro Yamada, Ping ity. Bo-Liang Li. Xiao-Xia Zhao. Xin-Yuan Liu. Hyon Suk Kim, Liang. Yasutomo Fukunaga. and Osamu Midorikawa. Karel Raska. Jr.. John R. Ortaldo. Barbara Schwartz, and Sidney *55S7 Malignant Transformation of Human Fibroblasts by a Intns- Pestka. fected N-ras Oncogene. Daniel M. Wilson, Dajun Yang, John E. 5333 Role of P450IIE1 in the Metabolism of 3-Hydroxypyridine, a Dillberger, Stephen E. Dietrich, Veronica M. Mäher, and Constituent of Tobacco Smoke: Redox Cycling and DNA Strand J. Justin McCormick. Scission by the Metabolite 2,5-Dihydroxypyridine. Sang Geon Kim and Raymond F. Novak. 5340 Substrate Specificity of the Exonuclease Associated with Calf Endocrinology DNA Polymerase <. Ralph D. Sabatino. Thomas W. Myers, and *5291 Regulation of Progesterone Receptor Gene Expression. Robert A. Bambara. E. Vegeto. M. G. Cocciolo. F. Raspagliesi. A. Piffanelli. R. Fontanelli, and A. Maggi. Carcinogenesis *5.

Downloaded from cancerres.aacrjournals.org on September 25, 2021. © 1990 American Association for Cancer Research. * 5234 Augmentation of Antibody Dependent Cell Mediated Cytotoxicity * 5-106 A Deletion Linked to a Poly(ADP-ribose) Polymerase Gene on following in Vivo Therapy with Recombinant Interleukin 2. Chromosome 13q33-qter Occurs Frequently in the Normal Black Jacquelyn A. Hank, Randy R. Robinson. Jean Surfus. Barbara Population as Well as in Multiple Tumor DNA. Kishor G. M. Mueller, Ralph A. Reisfeld. Nai-Kong Cheung, and Paul M. Bhatia. Barry W. Cherney. Konrad Huppi, Ian T. Magrath, Sondel. Jeffrey Cossman. Edward Sausville, Francisco Barriga, Bruce Johnson. Barry Gause, George Bonney, Janet Neequayi, Maria * 5263 Clonal Analysis of Lymphocytes from Tumor, Peripheral Blood, DeBernardi, and Mark Smulson. and Nontumorous Kidney in Primary Renal Cell Carcinoma. Tae-Yoon Kim. Andrew C. von Eschenbach, MaryLynne D. * 54.11 Cloning and Characterization of Human Tumor Cell Interstitial Filaccio, Kazuhiro Hayakawa. David R. Parkinson, Charles M. Collagenase. Nancy Smyth Templeton, Peter D. Brown, Anna T. Balch. and Kyogo Itoh. Levy, Inger M. K. Margulies. Lance A. Liotta. and William G. Stetler-Stevenson. *54I4 Antitumor Effects of a-Interferon and •y-Interferonona Murine Renal Cancer (Renca) ¡nVitro and in Vivo. T. J. Savers, T. A. 5581 Selection for Spontaneous Metastasis after Calcium Phosphate- Wiltrout. K. McCormick, C. Husted. and R. H. Wiltrout. mediated Transfer of DNA. Ruth J. Muschel. 5421 Monoclonal Antibody Therapy of Murine Lymphoma: Enhanced Preclinical Pharmacology and Experimental Therapeutics Efficacy by Concurrent Administration of Interleukin 2 or Lym- *5212 Activity of the Thymidylate Synthase Inhibitor 2-Desamino-Arl°- phokine-activated Killer Cells. Kirk R. Schultz, Jay P. Klarnet, propargyl-5,8-dideazafolic Acid and Related Compounds in Mu David J. Peace, Martin A. Cheever. Christopher C. Badger, Irwin rine (1.1210) and Human (\V1L2) Systems in Vitro and in I.I 210 D. Bernstein, and Philip D. Greenberg. in Vivo. Ann L. Jackman, Gordon A. Taylor, Brigid M. O'Connor. Joel A. Bishop, Richard G. Moran, and A. Hilary 5460 Potentiation of Natural Killer Cell Activity and Tumor Immunity by Diacetylputrescine. Terry L. Bowlin. Andrea Rosenberger, Calven. David Stemerick, and Michael L. Edwards. 5296 Failure of Chronic Glutathione Elevation to Reduce Cytotoxicity *54')7 Gangliosides and Sialoglycoproteins Carrying a Rare Blood Produced by Exposure to ci's-Diamminedichloroplatinum(II), Group Antigen Determinant, Cad, Associated with Human Can Ionizing Radiation, or Hyperthermia. Michael L. Freeman. cers as Detected by Specific Monoclonal Antibodies. Nozomu Michael J. Meredith, and Donald R. Eisert. Hiraiwa. Kiyotaka Tsuyuoka. Yu-Teh Li. Mitunobu Tanaka, 5318 Application of a New Approach for the Quantitation of Drug Syn- Taiko Seno, Yasuto Okubo. Yoshihiro Fukuda, Hiroo Imura, ergism to the Combination of m-Diamminedichloroplatinum and and Reiji Kannagi. l-/3-D-Arabinofuranosylc)tosine. William R. Greco, Hyoung 5515 Assessment of Protein Kinase C Isozymes by Enzyme Immu- Sook Park, and Youcef M. Rustum. noassay and Overexpression of Type II in Thyroid Adenocar- * 5399 Inhibition of Human Breast Cancer Cell Proliferation in Tissue cinoma. Masatoshi Hagiwara. Takahisa Hachiya. Masato Watanabe. Nobuteru Usuda, Futoshi lida. Katsuyuki Tamai, and Culture by the Neuroleptic Agents Pimozide and Thioridazine. Jeannine S. Strobl. Keith L. Kirkwood. Tracy K. Lantz. Michael A. Hiroyoshi Hidaka. Lewine. Virginia A. Peterson, and Jennings F. Worley III. 5543 In Vivo Administration of Interferon a and Interleukin 2 Induces Proliferation of Lymphoid Cells in the Organs of Mice. Raj K. 5475 Prevention of Central Nervous System Toxicity of the Antitumor Puri, William D. Travis, and Steven A. Rosenberg. Antibiotic Acivicin by Concomitant Infusion of an Amino Acid Mixture. Marta G. Williams. Robert H. Earhart, Howard Bailey, *555I In Vivo Interleukin 2-induced Activation of Lymphokine-acti- and J. Patrick McGovren. vated Killer Cells and Tumor Cytotoxic T-Cells in Cervical 5537 Role of Tumor Necrosis Factor in Flavone Acetic Acid-induced Lymph Nodes of Patients with Head and Neck Tumors. Licia Rivoltini. Carlo Gambacorti-Passerini. Massimo Squadrelli- Tumor Vasculature Shutdown. Viswanath Mahadevan, Saleem Saraceno, Maria Ilaria Grosso, Giulio Cantù, Roberto Molinari. T. A. Malik. Anthony Meager, Walter Fiers, Graham P. Lewis, Attilio Orazi, and Giorgio Parmiani. and Ian R. Hart. "*•5558Enhancement of Ricin A Chain Immunotoxin Activity by Perhex- iline on Established and Fresh Leukemic Cells. Jean-Pierre Molecular Biology and Genetics Jaftrezou. Thierry Levade, Emilienne Kuhlein, Olivier Thurneyssen. Marielle Chiron, HélèneGrandjean.Dominique * 52-10 Detection of Minimal Residual Disease in Leukemic Patients Carrière,and Guy Laurent. with the t(10;14)(q24;qll) Chromosomal Translocation. Jacob Tumor Biology Kagan, Lawrence R. Finger, Emanuel Besa, and Carlo M. Croce. * 5312 Abnormalities in Structure and Expression of the Retinoblastoma 5245 DNA Fingerprinting of 7,12-Dimethylbenz|a]anthracene-induced and Spontaneous CD-I Mouse Liver Tumors. Brian J. Ledwith, Gene in Small Cell Lung Cancer Cell Lines and Xenografts in Nude Mice. Kare Rygaard. George D. Sorenson, Olive S. Richard D. Storer, Srinivasa Prahalada. Sujata Manam, Karen R. Pettengill, Charles C. Cate, and Mogens Spang-Thomsen. Leander. Matthew J. van Zwieten. Warren W. Nichols, and Matthews O. Bradley. 5351 Role of Growth Factor Synthesis in the Acquisition of Insulin/ Insulin-like Growth Factor I Independence in Rat Mammary 5374 Identification of Ultraviolet-inducible Proteins That Bind to a Carcinoma Cells. Stephen P. Ethier, Caterina Chiodino, and TGACAACA Sequence in the Polyoma Virus Regulatory Region. Richard F. Jones. Zeev A. Ronai and I. Bernard Weinstein. *5392 Non-P-Glycoprotein Mediated Multidrug Resistance Precedes 5365 Porphyrin Photosensitivity in Cell Lines Expressing a Heat- P-Glycoprotein Expression during in Vitro Selection for resistant Phenotype. Charles J. Corner. Natalie Rucker, and Sam Wong. Doxorubicin Resistance in a Human Lung Cancer Cell Line. F. Baas, A. P. M. Jongsma, H. J. Broxterman, R. J. Arceci, * 5387 Effect of a-Interferon, 17/3-Estradiol, and Tamoxifen on Estrogen D. Housman, G. L. Scheffer. A. Riethorst. M. van Groenigen, Receptor Concentration and Cell Cycle Kinetics of MCF 7 Cells. A. W. M. Nieuwint. and H. Joenje. W. R. Bezwoda and K. Meyer.

Downloaded from cancerres.aacrjournals.org on September 25, 2021. © 1990 American Association for Cancer Research. Peripheral Airway Cell Differentiation in Human Lung Cancer 5358 Suppressor Cell Activity in a Randomized Trial of Patients Re Cell Lines. Adi F. Gazdar, R. Ilona Linnoila. Yukio Kurita. ceiving Active Specific Immunotherapywith Melanoma Cell Vac Herbert K. Oie, James L. Mulshine. Jean C. Clark, and Jeffrey A. cine and Low Dosages of Cyclophosphamide. Dave S. B. Hoon. Whitsett. Leland J. Foshag, Anne S. Nizze. Roger Bohman. and Donald L. Morton. *5520 Differentiation and Growth Modulation of Chronic Myelogenous Leukemia Cells by Bryostatin. Michael Lilly, Chris Tompkins, Chris Brown, George Pettit. and Andrew Kraft. Epidemiológica! 5526 Establishment and Characterization of a Tumorigenic Murine 5231 Smoking and Renal Cell Carcinoma. Carlo La Vecchia. Eva Vascular Endothelial Cell Line (F-2). Ken-Ichi Toda, Kaoni Negri. Barbara D'Avanzo, and Silvia Franceschi. Tsujioka, Yukiya Maruguchi, Kazuhiro Ishii, Yoshiki Miyachi, Kagemasa Kuribayashi. and Sadao Imamura. 5470 Ecological Correlation between Arsenic Level in Well Water and * 55.M Establishment and Characterization of Human Renal Cancer and Age-adjusted Mortality from Malignant Neoplasms. Chien-Jen Normal kidney Cell Lines. T. Eben. N. H. Bander, C. L. Finstad. Chen and Chin-Jen Wang. R. D. Ramsawak. and L. J. Old. Virology * 5287 Augmentation of Cytotoxic Effect of Tumor Necrosis Factor on Human Immunodeficiency Virus-infected Cells by Staurosporine, a Potent Protein Kinase C Inhibitor. Yoshiaki Hamamoto. Toshifumi Matsuyama. Naoki Yamamoto, and Nobuyuki Kobayashi. 5594 Announcements Eighty-second Annual Meeting of the AACR CLINICAL AND EPIDEMIOLOGICAL Call for Nominations for the Scientific Awards of the AACR INVESTIGATIONS AACR Special Conferences in Cancer Research Future Annual Meetings of the AACR Clinical Recent Death Calendar of Events 5345 Carbohydrate Analysis of Immunoglobulin G Myeloma Proteins by Lectin and High Performance LiquidChromatography:Role of Glycosyltransferases in the Structures. Tetsuo Nishiura, Shigeru 5596 Employment Register of the AACR Fujii. Yoshio Kanayama. Atsushi Nishikawa. Yoshiaki Tomiyama. Masato lida, Takahiro Karasuno. Hirohisa Nakao, Takeshi Yonezawa. Naoyuki Taniguchi, and Seiichiro Tarui. 5604 Author Index

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Cancer Res 1990;50:5211-5603.

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Downloaded from cancerres.aacrjournals.org on September 25, 2021. © 1990 American Association for Cancer Research.