Questions list «Pharmaceutical chemistry» for VII semestre 2016-2017 academic year

1. Medicinal products acting on cholinergic system. Cholinomimetic agents. M-cholinomimetics, pilocarpine hydrochloride. Chemical structure, physical properties, identification and quantitative analysis. 2. Medicinal products of anti-cholinesterase group, . Meta-aminophenol derivatives, Physostigmine salicylate. Physical properties, basic hydrolysis, quantitative analysis. Neostigmine methyl sulfate (Prostigmin, Vagostigmin). Physical properties, identity, quantitative analysis. 3. Cholinolytic medicinal products, their dosage forms. Products of this group having natural origin: atropine sulfate, hydrobromide. Natural source of Atropine sulfate, chemical synthesis, physical properties. 4. Cholinolytic agents having synthetic origin: homatropine hydrobromide, di-phenyltropane hydrochloride Tropacine, their chemical structures. General and special methods of identification. 5. Cholinolytic agents having synthetic origin: homatropine hydrobromide, di-phenyltropane hydrochloride Tropacine, their chemical structures. General and special methods of quantity detection. 6. Medicinal products acting on adrenergic system. Adrenomimetics (phenyl-alkylamines) ephedrine, dephedrine (pseudoephedrine), semisynthetic method of ephedrine hydrochloride synthesis. 7. Medicinal products acting on adrenergic system. Adrenomimetics (phenyl-alkylamines) ephedrine, dephedrine (pseudoephedrine), chemical structure, physicochemical properties, identification and quantity detection methods. 8. Catecholamines. Adrenaline hydrotartrate, hydrochloride (Epinephrine): Sources of Adrenaline, biosynthesis in the organism, industrial synthesis. 9. Catecholamines. Dophamine, adrenaline, noradrenaline synthesis physicochemical properties, identification and quantity detection methods. 10. Adrenoblockers (aryloxy propanolamines), anaprilin, propranolol, atenolol, timolol maleate, chemical structure, physical properties. Synthesis of timolol maleate, identity, quantitative analysis, usage. 11. Adrenaline and noradrenalin synthetic analoges-izadrine, phenetorol salbutamole. Synthesis, identification and quantity detection methods. 12. Medicinal products acting on CNS. Psycho-stimulants. Methylxanthine derivatives: caffeine, theophylline, theobromine. Natural sources of purine alkaloids and synthesis methods. 13. Medicinal products acting on CNS. Psycho-stimulants. Physicochemical properties, general reaction (Murexide sample), identification and quantitative analysis, usage. Double salts of purine alkaloids: Caffeine-sodium benzoate. Euphylline. Identification reactions. 14. Medicinal products acting on CNS. Psycho-stimulants. Diprophylline structure and identification reactions.

@YSMU Departments Blank.doc 15. : phenothiazine derivatives , , levomepromazine, trifluoperazine hydrochloride, ethmozine, ethacyzin, chemical structures, physical properties, identification reactions. 16. Antipsychotics: phenothiazine derivatives promethazine, chlorpromazine, levomepromazine, trifluoperazine hydrochloride, ethmozine, ethacyzin, general and special identification methods. 17. Antipsychotics: phenothiazine derivatives promethazine, chlorpromazine, levomepromazine, trifluoperazine hydrochloride, ethmozine, ethacyzin, quantity detection methods. 18. Somnolents barbituric acid derivatives: , , sodium, thiopental sodium, barbital sodium, hexenal, benzobarbital (benzonal), chemical properties, synthesis. 19. Somnolents barbituric acid derivatives: barbital, phenobarbital, hexobarbital sodium, thiopental sodium, barbital sodium, hexenal, benzobarbital (benzonal), identification general and partial methods. 20. Somnolents barbituric acid derivatives: barbital, phenobarbital, hexobarbital sodium, thiopental sodium, barbital sodium, hexenal, benzobarbital (benzonal), quantitative analysis. 21. derivatives. , fhenazepam, , , synthesis, physicochemical properties. 22. Benzodiazepine derivatives. diazepam, fhenazepam, nitrazepam, oxazepam identification, quantitative analysis. 23. , classification. Tricyclic antidepressants. , Imipramin, physical properties, identification, quantitative analysis. 24. Antidepressants. Izonicotinic acid hydrazide derivative: nialamide. Identification, quantitative analysis. 25. Antidepressants. Phenoxypropylamine analog hydrochloride. Identification, quantitative analysis. 26. Nootropics. GABA derivatives: aminalon, chemical properties,identification, quantitative analysis. 27. Nootropics. GABA derivatives: picamilone, chemical properties,identification, quantitative analysis. 28. Nootropics. GABA derivatives: piracetame, synthesis ,identification, quantitative analysis. 29. Local anesthetics. Para-amino benzoic acid derivatives: Novocain, Novocainamide, dicaine, anesthesinе, chemical structure, physical properties, identification, quantitative analysis. 30. Local anesthetics. Para-amino benzoic acid derivatives: Novocain, Novocainamide, dicaine, anesthesinе, identification general and special methods. 31. Local anesthetics. Para-amino benzoic acid derivatives: Novocain, Novocainamide, dicaine, anesthesinе, quantity detection methods. 32. Local anesthetics. Acetanilide derivatives: lidocaine, trimecaine, synthesis, physical properties, identification, quantitative analysis, usage. 33. Non-narcotic analgesics. Pyrazole derivatives: phenazone (antipyrine), chemical structure, synthesis, identification, quantitative analysis. 34. Non-narcotic analgesics. Pyrazole derivatives: methimazole (analgine), chemical structure, synthesis, identification, quantitative analysis. 35. Non-narcotic analgesics. Pyrazole derivatives: phenylbutazone (buthadion), chemical structure, synthesis, identification, quantitative analysis.

@YSMU Departments Blank.doc 36. Non-narcotic analgesics. Salicylic acid derivatives- salicylic acid, acetyl salicylic acid, synthesis, physical properties, identification, quantitative analysis. 37. Non-narcotic analgesics. Salicylic acid derivatives- salicylamide, phenylsalicilat, synthesis, physical properties, identification, quantitative analysis. Antranilic acid derivatives: phenamates, structures. 38. Para aminophenol derivatives : Paracetamole, structure, identification, quantitative analysis. 39. Narcotic analgesics. Phenantren isochinoline /morphinan/ derivatives. hydrochloride, chemical structure, physicochemical properties. 40. Narcotic analgesics. Phenantren isochinoline /morphinan/ derivatives. Morphine hydrochloride, identification, quantitative analysis. 41. Narcotic analgesics. Morphine derivatives: codeine, codeine phosphate, chemical structure, physical properties. 42. Narcotic analgesics. Morphine derivatives: codeine, codeine phosphate, identification, quantitative analysis. 43. Narcotic analgesics. Morphine derivatives: Naltrexone hydrochloride, chemical structure, physical properties, identification, quantitative analysis. 44. Narcotic analgesics. Apomorphine hydrochloride, synthesis, identification, quantitative analysis. 45. Narcotic analgesics. Promedole, synthesis, identification, quantitative analysis. 46. Antihistaminic products- H1 histamine receptor blockers. Diphenyl hydramin hydrochloride /dimedrol/, chemical structure. Synthesis. 47. Antihistaminic products- H1 histamine receptor blockers. Diphenyl hydramin hydrochloride /dimedrol/, identification, quantitative analysis. 48. Antihistaminic products- H1 histamine receptor blockers. Chlorpyramine hydrochloride (suprastine), identification, quantitative analysis. 49. H2 histamine receptor blockers, ranitidine hydrochloride, synthesis, physical properties, identification, quantitative analysis, usage. 50. Calcium antagonists. Nifedipine chemical structure, synthesis, identification, quantitative analysis, usage. 51. Calcium antagonists. Verapamil chemical structure, identification, quantitative analysis. 52. Drugs acting on blood system. Neodicumarine, phepromaron, warfarin, synthesis, identification, quantitative analysis. 53. Drugs acting on blood system. Indandione derivatives, phenyllin, identification, quantitative analysis. 54. Spasmolytics: Benzylisoquinoline derivatives. Papaverin, drotaverin /no-spa/ hydrochloride, chemical structure, physical properties. Papaverin hydrochloride synthesis physical properties. 55. Spasmolytics: Benzylisoquinoline derivatives. Papaverin, drotaverin /no-spa/ hydrochloride, chemical structure, physical properties. Papaverin hydrochloride identification, quantitative analysis, storage conditions, usage. 56. Spasmolytics: Benzimidazole derivatives: dibazole /bendazol/. Dibazole hydrochloride chemical structure, synthesis, identification, quantitative analysis, storage conditions, usage. 57. Nitrates- nitroglycerine, nitrosorbit, isosorbit mono-nitrate, erinite, synthesis, physical properties, identification, quantitative analysis, storage conditions, usage, dosage form.

@YSMU Departments Blank.doc 58. Anti-metabolites. Pyrimidine derivatives. Uracil derivatives, fluorine-uracil, methyl-uracil, tegafur- uracil (ftorafur), zidovudine, stavudine. Fluorine-uracil synthesis, physical properties, identification, quantitative analysis. 59. Anti-metabolites. Pyrimidine derivatives. Uracil derivativesmethyl-uracil, synthesis, physical properties, identification, quantitative analysis. 60. Purine synthetic derivatives. Mercaptopurine, synthesis, identification, quantitative analysis. 61. Purine synthetic derivatives. Azathioprine, riboxin, allopurinol, physical properties, identity, quantitative analysis. 62. Hormones. Corticosteroids: cortizon, industrial synthesis. Physical properties, Identity, quantitave analysis. 63. Hormones. Corticosteroids, fluorine derivatives /semi-synthetic dexamethasone, triamcinolone, flumethasone pivalate, fluocinolone acetonide, synthesis, identity, quantitative analysis. 64. Female sex hormones. Hestagen and semi-synthetic derivatives. and its semi- synthetic derivatives norethisterone and met-oxy-progesterone acetate. Progesterone synthesis, identification quantitative analysis. 65. Estrogen hormones- estrone, estrion, estradiol, estradiol di-propionate, ethinyl estradiol, sinthesys, physical properties, identification, quantitative analysis. 66. Synthetic estrogenes: hexestrol, diethylstilbesterol, sinthesys, physical properties, identification, quantitative analysis. 67. Male sex hormones. Androgens. Natural androgen hormones , dehydroandrosteron, testosteron. industrial synthesis. 68. Male sex hormones. Androgens. Testosterone semi-synthetic derivatives- testosterone propionate and methyl-testosterone, sinthesys, physical properties, identification, quantitative analysis. 69. Male sex hormones. Androgens synthetic derivatives : methandriol, methandienon, physical properties, identification, quantitative analysis. 70. Synthetic anabolic compounds: 19-nortestoteron derivatives. Nandrelon phenyl propionate /phenobolin/, nandrelon deaconate /retabolil/. Identification, quantitative analysis.

List of Reference Books 1.Drug chemistry, subject lectures worked out by the department. 2. A.G. Zhamharyan, F. A. Sargsyan, E. L.Yeritsyan. ,, Drug chemistry,, textbook for pharmaceutical faculty lV year students, 2013, Yerevan. 3.Pharmaceutical chemistry, R.H.Hakobyan, 2007, Yerevan

Head of Department associate prof. A.G.Zhamharyan

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