MRPL40 Antibody Cat. No.: 60-027

MRPL40 Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

This MRPL40 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 172-200 amino acids from the C-terminal region of human MRPL40.

TESTED APPLICATIONS: WB

APPLICATIONS: For WB starting dilution is: 1:1000

PREDICTED MOLECULAR 24 kDa WEIGHT:

Properties

This antibody is purified through a A column, followed by peptide affinity PURIFICATION: purification.

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

October 2, 2021 1 https://www.prosci-inc.com/mrpl40-antibody-60-027.html PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: MRPL40

39S L40, mitochondrial, L40mt, MRP-L40, Nuclear localization signal- ALTERNATE NAMES: containing protein deleted in velocardiofacial syndrome, Up-regulated in metastasis, MRPL40, NLVCF, URIM

ACCESSION NO.: Q9NQ50

PROTEIN GI NO.: 21263795

GENE ID: 64976

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Mammalian mitochondrial ribosomal are encoded by nuclear and help in protein synthesis within the . Mitochondrial (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic BACKGROUND: ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by . This encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio- facial syndrome and DiGeorge syndrome.

REFERENCES: 1) Collins, J.E., et al. Genome Biol.(10), R84 (2004) :

2) Zhang, Z., et al. Genomics 81(5):468-480(2003)

3) Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :

4) Hildebrandt, T., et al. Anticancer Res. 19 (1A), 525-530 (1999) :

ANTIBODIES FOR RESEARCH USE ONLY.

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