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Home , Azaperone, Bifeprunox, Clopenthixol, Dopamine antagonist, Etilevodopa, Fananserin

Dopamine

Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal signaling and nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic targets; are often dopamine receptor antagonists while psychostimulants are typically indirect of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.

www.MedChemExpress.com 1 Dopamine Receptor Antagonists, Agonists, Inhibitors, Modulators & Activators

(+)- hydrochloride (+)-PD 128907 hydrochloride ((+)-DAR-0100 hydrochloride) Cat. No.: HY-101299 Cat. No.: HY-110000

(+)-Dihydrexidine hydrochloride ((+)-DAR-0100 (+)-PD 128907 hydrochloride is a selective

hydrochloride) is a dopamine D1 receptor dopamine D2/D3 receptor , with Kis of

agonist with an EC50 of 72± 21 nM. 1.7, 0.84 nM for human and rat D3 receptors, 179,

770 n M for human and rat D3 receptors, respectively.

Purity: >98% Purity: 98.83% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg

(-)-GSK598809 (-)-Isocorypalmine (1S,5R-GSK598809) Cat. No.: HY-19654B (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) Cat. No.: HY-N0927

(-)-GSK598809 is an isomer of GSK598809. GSK598809 (-)-Isocorypalmine (Tetrahydrocolumbamine), is a potent and selective dopamine D3 Receptor isolated from the crude base fraction of Corydalis (DRD3) antagonist. chaerophylla, is a dopamine receptor ligand. Recombinant CYP719A21 displays strict substrate

specificity and high affinity (Km=4.63 ± 0.71 μM) for (-)-Isocorypalmine. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg

(Rac)-PF-06256142 (Rac)- hydrochloride Cat. No.: HY-119943A Cat. No.: HY-15394

(Rac)-PF-06256142 is the less effective enantiomer (Rac)-Rotigotine hydrochloride is a racemate of of PF-06256142 (HY-119943). (Rac)-PF-06256142 is Rotigotine.

an agonist of D1 receptor, with an EC50 of 107 nM. (Rac)-PF-06256142 can be used for the research of and Parkinson's disease.

Purity: >98% Purity: 97.76% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

(Rac)-Tavapadon (±)-Methotrimeprazine (D6) ((Rac)-PF-06649751; (Rac)-CVL-751) Cat. No.: HY-119486A (dl-Methotrimeprazine D6) Cat. No.: HY-19489S

(Rac)-Tavapadon ((Rac)-PF-06649751) is a potent (±)-Methotrimeprazine (D6) is the deuterium and selective noncatechol dopamine D1 receptor labeled Methotrimeprazine, which is a D3 . and H1 .

Purity: 99.63% Purity: >98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg

2'-O-Methylisoliquiritigenin 3-O- Cat. No.: HY-N1745 (3-Methoxy-L-; 3-O-Methyl-L-DOPA) Cat. No.: HY-113468A

2'-O-Methylisoliquiritigenin, isolated from the 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a Arachis species, up-regulates 5-HT, NE, DA and metabolite of L-DOPA which is formed by GABA pathways, but does not put a very catechol-O-methyltransferase (COMT). significant effect on ne NE pathway. 3-O-Methyldopa competitively inhibits the of l-DOPA and dopamine.

Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 1 mg, 5 mg

2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

3-O-Methyldopa D3 5-HT6/7 antagonist 1 (3-Methoxy-L-tyrosine D3; 3-O-Methyl-L-DOPA D3) Cat. No.: HY-113468AS Cat. No.: HY-101622

3-O-Methyldopa D3 (3-Methoxy-L-tyrosine D3) is 5-HT6/7 antagonist 1 is a multifunctional ligand deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa that antagonizes 5-HT6/7/2A and D2 receptors, is a metabolite of L-DOPA which is formed by without interacting with M1 receptors and hERG catechol-O-methyltransferase (COMT). channels. 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine. Purity: ≥99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

A-381393 A-437203 Cat. No.: HY-116941 (Lu201640; A37203) Cat. No.: HY-U00185

A-381393 is a potent, selective, penetrate A-437203 is a selective D3 receptor antagonist dopamine D4 receptor antagonist, with Kis of with Ki of 71, 1.6, and 6220 nM for D2, D3, and

1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4 receptors, respectively.

D4.2, and D4.7 receptor, respectively,

>2700-fold selectivity over D1, D2, D3 and

D5 dopamine receptors. Purity: 99.96% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Abaperidone ABT-670 Cat. No.: HY-101619 Cat. No.: HY-19483

Abaperidone is a potent antagonist of ABT-670 is a selective, oral bioavailable agonist

5-HT2Areceptor and dopamine D2 receptor of dopamine D4 receptor, with EC50 of 89 with IC50s of 6.2 and 17 nM. nM, 160 nM, and 93 nM for humanD4, ferretD4,

and ratD4, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

ABT-724 ABT-724 trihydrochloride Cat. No.: HY-14330 Cat. No.: HY-103409

ABT-724 is a potent and highly selective ABT-724 trihydrochloride is a potent and highly dopamine D4 receptor agonist with an EC50 selective dopamine D4 receptor agonist with of 12.4 nM for human dopamine D4 receptor. an EC50 of 12.4 nM for human dopamine D4 ABT-724 is a potent at the rat receptor.

D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). Purity: >98% Purity: 99.12% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

Adoprazine hydrochloride (SLV313) Cat. No.: HY-14782 Cat. No.: HY-A0125A

Adoprazine (SLV313) is a full 5-HT1A receptor Alizapride hydrochloride is a dopamine agonist with a pEC50 of 9 at cloned h5-HT1A receptor antagonist with prokinetic and receptors. Adoprazine (SLV313) is a full D2 and effects which can also be used in the treatment of and , including D3 receptor antagonist with pA2s of 9.3 and postoperative nausea and vomiting. 8.9 at hD2 and hD3 receptors, respectively.

Purity: 98.10% Purity: 99.95% Clinical Data: Phase 1 Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg Size: 10 mM × 1 mL, 50 mg, 100 mg

www.MedChemExpress.com 3

Amisulpride hydrochloride (DAN 2163) Cat. No.: HY-14545 (DAN 2163 hydrochloride) Cat. No.: HY-14545A

Amisulpride is a dopamine D2/D3 receptor Amisulpride hydrochloride is a dopamine D2/D3

antagonist with Kis of 2.8 and 3.2 nM for human receptor antagonist with Kis of 2.8 and 3.2 nM

dopamine D2 and D3, respectively. for human dopamine D2 and D3, respectively.

Purity: 99.96% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg Size: 1 mg, 5 mg

Ansofaxine hydrochloride (LY03005; LPM570065) Cat. No.: HY-U00096 (Org 5222) Cat. No.: HY-10121

Ansofaxine hydrochloride (LY03005; LPM570065) is a Asenapine (Org 5222), an atypical ,

triple inhibitor; inhibits , is an antagonist of serotonin receptors (pKi:

dopamine and reuptake with IC50 8.4-10.5), adrenoceptors (pKi: 8.9-9.5),

values of 723, 491 and 763 nM, respectively. dopamine receptors (pKi: 8.9-9.4) and

histamine receptors (pKi: 8.2-9.0).

Purity: 99.85% Purity: 98.81% Clinical Data: Phase 1 Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 20 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Asenapine hydrochloride Asimilobine Cat. No.: HY-16567 Cat. No.: HY-N7512

Asenapine hydrochloride, an antipsychotic, is a Asimilobine is an isoquinoline 5-HT (1A, 1B, 2A, 2B, , 5A, 6, 7) and isolated from plant species of Magnolia obobata

Dopamine (D2, D3, D4) receptor antagonist with Thun. Asimilobine is a dopamine biosynthesis

Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, inhibitor and a receptor antagonist. 1.1 nM for Dopamine receptor, respectively. Asimilobine shows an antimalarial and anti-cancer activity. Purity: 98.76% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Azaperone Derivative 1 (R-1929) Cat. No.: HY-B1470 Cat. No.: HY-U00415

Azaperone (R-1929) acts as a Benzamide Derivative 1 is a benzamide derivative but also has some antihistaminic and from patent EP0213775A1, compound 18. Benzamide properties. Derivative 1 may be useful in treatment of gastrointestinal disorders.

Purity: 99.77% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 1 mg, 5 mg

Benztropine mesylate ( mesylate; Benzotropine BGC20-761 mesylate; Benztropine methanesulfonate) Cat. No.: HY-B0520A Cat. No.: HY-21995

Benztropine mesylate (Benzatropine mesylate) is an BGC20-761 is a selecvtive 5-HT6 and dopamine

orally active centrally acting anticholinergic receptor antagonist (human receptor Ki values: agent that can be used for Parkinson's disease 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). research. Benztropine mesylate is an BGC20-761, can enhance long-term memory. BGC20-761 anti-histamine agent and a dopamine re-uptake has potential utility as an antipsychotic agent. inhibitor. Purity: 99.86% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg, 1 g Size: 1 mg, 5 mg

4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Bifeprunox Cat. No.: HY-14547 (AD-5423) Cat. No.: HY-13575

Bifeprunox is a potent dopamine D2-like and Blonanserin (AD-5423) is a potent and orally

5-HT1A receptor partial agonist with pKis of active 5-HT2A (Ki=0.812 nM)

7.19 and 8.83 for cortex 5-HT1A and D2, and dopamine D2 receptor (Ki and a pEC50 of 6.37 for 5-HT1A, =0.142 nM) antagonist. respectively. Bifeprunox is an antipsychotic for the research of schizophrenia. Purity: >98% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 25 mg, 100 mg

Blonanserin D5 Blonanserin D8 (AD-5423 D5) Cat. No.: HY-13575S1 (AD-5423 D8) Cat. No.: HY-13575S

Blonanserin D5 (AD-5423 D5) is a deuterium labeled Blonanserin D8 (AD-5423 D8) is a deuterium labeled Blonanserin. Blonanserin is a dopamine Blonanserin. Blonanserin is a dopamine

D2/5-HT2 receptor antagonist and an atypical D2/5-HT2 receptor antagonist and an . antipsychotic.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

BP 897 Cat. No.: HY-106660 (OPC-34712) Cat. No.: HY-15780

BP 897 is a potent and selective dopamine D3 Brexpiprazole (OPC-34712), an atypical receptor agonist, and a weak dopamine D2 antipsychotic drug, is a partial agonist of human receptor antagonist, with Kis of 0.92 nM and 61 5-HT1A and dopamine receptor with Kis of 0.12 nM for D3 and D2 receptors, and shows low nM and 0.3 nM, respectively. Brexpiprazole is also affinities at D1 and D4 receptors (Kis, 3 and a 5-HT2A receptor antagonist with a Ki of 0.47 0.3µM, respectively). nM. Purity: >98% Purity: 99.40% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

Brexpiprazole D8 Brexpiprazole S-oxide (OPC-34712 D8) Cat. No.: HY-15780S (DM-3411) Cat. No.: HY-133152

Brexpiprazole D8 (OPC-34712 D8) is a deuterium Brexpiprazole S-oxide (DM-3411) is a main labeled Brexpiprazole (OPC-34712). Brexpiprazole, metabolite of Brexpiprazole and is metabolized by an atypical antipsychotic drug, is a partial cytochrome P450 3A4 (CYP3A4). agonist of human 5-HT1A and dopamine receptor

(Ki=0.12 nM and 0.3 nM, respectively).

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg

Brexpiprazole S-oxide D8 Brilaroxazine (DM-3411 D8) Cat. No.: HY-133152S (RP5063) Cat. No.: HY-109112

Brexpiprazole S-oxide D8 (DM-3411 D8) is a Brilaroxazine (RP5603) is a potent and orally deuterium labeled Brexpiprazole S-oxide. active multimodal dopamine (DA)/serotonin Brexpiprazole S-oxide is a main metabolite of (5-HT) modulator. Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4).

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

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Bromocriptine mesylate (CB-154) Cat. No.: HY-12705A Cat. No.: HY-B1164

Bromocriptine mesylate is a potent dopamine Bromopride is a dopamine antagonist with D2/D3 receptor agonist, which binds D2 dopamine prokinetic properties, widely used as an

receptor with pKi of 8.05±0.2. antiemetic.

Purity: 99.98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg Size: 1 mg, 5 mg

Bupropion D9 Cat. No.: HY-B0403S (FCE-21336) Cat. No.: HY-15296

Bupropion D9 is a deuterium labeled Bupropion. Cabergoline is an derived-dopamine D2-like

Bupropion is an atypical of the receptor agonist that has high affinity for D2,

aminoketone group and inhibits dopamine, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and norepinephrine reuptake and blocks several 1.2, respectively). nicotinic receptors.

Purity: >98% Purity: 99.44% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg

Cariprazine hydrochloride (RGH-188) Cat. No.: HY-14763 (RGH188 hydrochloride) Cat. No.: HY-14763A

Cariprazine is a novel antipsychotic drug Cariprazine hydrochloride is a novel antipsychotic

candidate that exhibits high affinity for the D3 drug candidate that exhibits high affinity for the

(Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM)

moderate affinity for the 5-HT1A receptor receptors, and moderate affinity for the 5-HT1A

(Ki=2.6 nM). receptor (Ki=2.6 nM).

Purity: 99.35% Purity: 99.89% Clinical Data: Launched Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 25 mg, 50 mg

Carmoxirole hydrochloride CGP 25454A (EMD 45609 hydrochloride) Cat. No.: HY-103410 Cat. No.: HY-100454

Carmoxirole hydrochloride (EMD 45609 CGP 25454A is a novel and selective presynaptic hydrochloride) is a selective, peripherally acting dopamine autoreceptor antagonist. dopamine D2 receptor agonist and exhibits antihypertensive activities in vivo.

Purity: ≥98.0% Purity: 99.46% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 5 mg, 10 mg, 50 mg, 100 mg

Chlorprothixene hydrochloride Cat. No.: HY-B0274 Cat. No.: HY-B0274A

Chlorprothixene is a dopamine and histamine Chlorprothixene hydrochloride is a dopamine and

receptors antagonist with Kis of 18 nM, 2.96 nM, histamine receptors antagonist with Kis of 18 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, and hH1 receptors, respectively. Antipsychotic hD2, hD3, hD5 and hH1 receptors, respectively. activity. Antipsychotic activity.

Purity: 99.13% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg Size: 50 mg, 100 mg, 200 mg, 500 mg

6 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

cis-(Z)-Flupentixol dihydrochloride malate (cis-(Z)-Flupenthixol dihydrochloride) Cat. No.: HY-15856 Cat. No.: HY-B1613A cis-(Z)- dihydrochloride is a potent Clebopride malate is a dopamine antagonist drug and selective DA D1/D2 receptor antagonist, with with antiemetic and prokinetic properties used to

Ki values of 0.38 nM and 7 nM for D2 receptor and treat functional gastrointestinal disorders.

5-HT2A, respectively. Target: dopamine Clebopride is a substituted benzamide, closely related to .

Purity: >98% Purity: 99.46% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Clomipramine D3 D3 hydrochloride Cat. No.: HY-B0457AS Cat. No.: HY-B0457S

Clomipramine D3 is the deuterium labeled Clomipramine D3 hydrochloride is a deuterium Clomipramine. Clomipramine is a serotonin labeled Clomipramine hydrochloride. Clomipramine transporter (SERT), norepinephrine transporter hydrochloride is a serotonin transporter (SERT),

(NET) dopamine transporter (DAT) blocker with Ki of norepinephrine transporter (NET) dopamine

0.14, 54 and 3 nM, respectively. transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Clomipramine hydrochloride Cat. No.: HY-B0457 (HF 1854) Cat. No.: HY-14539

Clomipramine hydrochloride is a serotonin Clozapine (HF 1854) is an antipsychotic used for transporter (SERT), norepinephrine transporter the research of schizophrenia. Clozapine is a (NET) and dopamine transporter (DAT) blocker potent antagonist of dopamine and a number of with Ki of 0.14, 54 and 3 nM, respectively. other receptors, with a Ki of 9.5 nM for muscarinic M1 receptor.

Purity: 99.49% Purity: 99.74% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 10 mM × 1 mL, 100 mg, 500 mg, 1 g, 5 g

Clozapine D8 Clozapine N-oxide (HF 1854 D8) Cat. No.: HY-14539S Cat. No.: HY-17366

Clozapine D8 (HF 1854 D8) is the deuterium labeled Clozapine N-oxide is a major metabolite of Clozapine. Clozapine, an antipsychotic, is a Clozapine and a human muscarinic designer potent antagonist of dopamine and a number of receptors (DREADDs) agonist. Clozapine N-oxide other receptors, with a Ki of 9.5 nM for muscarinic activates the DREADD receptor hM3Dq and M1 receptor. hM4Di. Clozapine N-oxide can cross the blood-brain barrier. Purity: >98% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Clozapine N-oxide dihydrochloride CY 208-243 Cat. No.: HY-17366A Cat. No.: HY-106094

Clozapine N-oxide dihydrochloride is a major CY 208-243 is a selective dopamine D1 receptor metabolite of Clozapine and a human which exhibits antiparkinsonian activity. designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di.

Purity: 98.17% Purity: 99.78% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg

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D-Tetrahydropalmatine Desmethyl cariprazine Cat. No.: HY-N2003 Cat. No.: HY-100656

D- is an isoquinoline alkaloid, Desmethyl cariprazine is an active metabolite of mainly in the genus Corydalis. Cariprazine. Cariprazine, an antipsychotic drug D-Tetrahydropalmatine is a dopamine (DA) candidate, exhibits high affinity for the D3

receptor antagonist with preferential affinity (Ki=0.085 nM) and D2 (0.49 nM) receptors, and toward the D1 receptors. moderate affinity for the 5-HT1A receptor (2.6 nM). Purity: 99.53% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 5 mg

Dexpramipexole Dexpramipexole dihydrochloride ((R)- ((R)-Pramipexole; R-(+)-Pramipexole; KNS-760704) Cat. No.: HY-17355B dihydrochloride; R-(+)-Pramipexole dihydrochloride; …) Cat. No.: HY-17355A

Dexpramipexole(KNS-760704), also known as Dexpramipexole dihydrochloride ((R)-Pramipexole R-(+)-Pramipexole, is a neuroprotective agent and dihydrochloride) is a neuroprotective agent and weak non- dopamine agonist. weak non-ergoline dopamine agonist.

Purity: >98% Purity: 99.71% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 25 mg, 50 mg, 100 mg

Dicarbine Didesmethyl cariprazine Cat. No.: HY-127086 Cat. No.: HY-100658

Dicarbine blocks dopamine receptors in various Didesmethyl cariprazine is a metabolite of brain parts and prevents the depression of the Cariprazine and acts as the predominant conditioned defence reflexes caused by stimulation circulating active moiety. Didesmethyl cariprazine of the mesencephalic portion of the reticular has a long half-life of 1-3 weeks. formation. Dicarbine could be used in the schizophrenia and alcoholic studies. Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg

Dihydrexidine Dihydrexidine hydrochloride (DAR-0100) Cat. No.: HY-101299A (DAR-0100 hydrochloride) Cat. No.: HY-101299B

Dihydrexidine (DAR-0100) is a high potent, Dihydrexidine hydrochloride (DAR-0100 selective and full efficacy D1-like dopamine hydrochloride) is a high potent, selective and

receptor (D1/D5) agonist with an IC50 of 10 nM full efficacy D1-like dopamine receptor (D1/D5)

for D1 receptor. Dihydrexidine exhibits potent agonist, with an IC50 of 10 nM for D1 receptor. antiparkinsonian activity. Dihydrexidine can Dihydrexidine hydrochloride exhibits potent stimulate YAP phosphorylation. antiparkinsonian activity. Purity: >98% Purity: 98.90% Clinical Data: Phase 1 Clinical Data: Phase 2 Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Domperidone Dopamine D2 receptor antagonist-1 (R33812) Cat. No.: HY-B0411 Cat. No.: HY-129946

Domperidone (R33812) is a selective dopamine-2 Dopamine D2 receptor antagonist-1 is a negative receptor antagonist. Domperidone acts as an (NAM) of the dopamine D2 antiemetic and a through its receptor (D2R) with sub-mM affinity. effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine.

Purity: 99.40% Purity: 99.05% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

8 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Droperidol (Dehydrobenzperidol) Cat. No.: HY-B1240 (L-DOPA ethyl ester; Levodopa ethyl ester) Cat. No.: HY-116016

Droperidol is a Dopamine-2 Receptor Antagonist. Etilevodopa (L-Dopa ethyl ester), an ethyl-ester Target: D2DR Droperidol is a , with of Levodopa, is rapidly hydrolyzed to anti-emetic, and anti- properties. Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD).

Purity: 99.29% Purity: ≥97.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

Etilevodopa hydrochloride (L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride) Cat. No.: HY-116016A (RP 62203) Cat. No.: HY-103104

Etilevodopa (L-Dopa ethyl ester) hydrochloride, an Fananserin (RP 62203) is an orally bioavailable, ethyl-ester prodrug of Levodopa, is rapidly potent and selective 5-hydroxytryptamine2 hydrolyzed to Levodopa and ethanol by nonspecific (5-HT2) receptor antagonist, with a Ki of 0.37 esterases in the gastrointestinal tract. nM for the rat 5-HT2A receptor. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Purity: 98.93% Purity: 99.83% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

FAUC 346 Cat. No.: HY-138809 (SKF 82526) Cat. No.: HY-B0735

FAUC 346, a highly selective D3 partial agonist Fenoldopam(SKF 82526) is a drug and synthetic

(EC50 = 1.5 nM), also demonstrates an inhibitory benzazepine derivative which acts as a selective effect on -seeking behavior. D1 receptor partial agonist. Target: D1 Receptor Fenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties.

Purity: 99.90% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Fenoldopam mesylate dihydrochloride (Fenoldopam methanesulfonate; SKF-82526 mesylate) Cat. No.: HY-B0735A Cat. No.: HY-B0358A

Fenoldopam(SKF 82526) mesylate is a drug and Flunarizine dihydrochloride is a potent dual synthetic benzazepine derivative which acts as a Na+/Ca2+ channel (T-type) blocker. Flunarizine selective D1 receptor partial agonist. Target: D1 dihydrochloride is a D2 dopamine receptor Receptor Fenoldopam is a selective dopamine-1 antagonist. (DA1) agonist with natriuretic/diuretic properties. Purity: 99.86% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 500 mg

Fluphenazine decanoate dihydrochloride Cat. No.: HY-B1904 Cat. No.: HY-A0081

Fluphenazine decanoate is a long-acting Fluphenazine dihydrochloride is a neuroleptic that used to treat phenothiazine-class D1DR and D2DR inhibitor; used schizophrenia. Fluphenazine decanoate is also a to deliver Fluphenazine to biological systems in high and continuous dopamine D2 receptor studies probing the effects and metabolic fates of blocker. this commonly used dopamine antagonist.

Purity: 99.48% Purity: 99.27% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 100 mg

www.MedChemExpress.com 9

Foscarbidopa GBR 12783 (Carbidopa 4′-monophosphate) Cat. No.: HY-109131 Cat. No.: HY-W008610

Foscarbidopa ( 4′-monophosphate) is a GBR 12783 is a specific, potent and selective prodrug of Carbidopa, acts as a dopamine dopamine uptake inhibitor that inhibits the receptor agonist. [3H]dopamine uptake by rat and mice striatal

synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

GBR 12783 dihydrochloride Cat. No.: HY-100968 (O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396) Cat. No.: HY-N3945

GBR 12783 dihydrochloride is a specific, potent Glaucine (O,O-Dimethylisoboldine) is an alkaloid and selective dopamine uptake inhibitor that isolated from Glaucium flavum Crantz with inhibits the [3H]dopamine uptake by rat and antitussive, bronchodilation and anti-inflammatory

mice striatal synaptosomes with IC50s of 1.8 nM properties. and 1.2 nM, respectively.

Purity: ≥98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 1 mg, 5 mg

GR 103691 GSK163090 Cat. No.: HY-101382 Cat. No.: HY-14348

GR 103691 is a potent, selective dopamine D3 GSK163090 is a potent, selective and orally active

receptor antagonist with a Ki value of 0.4 nM. GR 5-HT1A/1B/1D receptor antagonist with pKi 103691 shows more than 100-fold selectivity for values of 9.4/8.5/9.7, respectively. GSK163090

human dopamine human (h)D3 over hD4 and hD1 inhibits the functional activity of serotonin

sites. reuptake transporter (SerT) with a pKi value of 6.1. Purity: 99.95% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

GSK598809 Halopemide Cat. No.: HY-19654 Cat. No.: HY-119093

GSK598809 is a potent and selective dopamine D3 Halopemide is a potent phospholipase D (PLD)

Receptor (DRD3) antagonist, with a pKi of 8.9. inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent.

Purity: 99.73% Purity: 98.54% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

Haloperidol (D4') Cat. No.: HY-14538 Cat. No.: HY-14538S1

Haloperidol is a potent dopamine D2 receptor Haloperidol D4' is deuterium labeled haloperidol, antagonist, widely used as an antipsychotic. and the latter is a potent dopamine D2 receptor antagonist.

Purity: 99.77% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 5 mg

10 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Haloperidol D4 Haloperidol hydrochloride Cat. No.: HY-14538S Cat. No.: HY-14538A

Haloperidol D4 is deuterium labeled haloperidol, Haloperidol hydrochloride is a potent dopamine and the latter is a potent dopamine D2 D2 receptor antagonist, widely used as an receptor antagonist. antipsychotic.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Hydroxy Cat. No.: HY-100649 (HP 873) Cat. No.: HY-17410

Hydroxy ziprasidone is an impurity of Ziprasidone. Iloperidone (HP 873) is a D2/5-HT2 receptor Ziprasidone, an antipsychotic agent, is a combined antagonist. Iloperidone is an atypical 5-HT (serotonin) and dopamine receptor antagonist. antipsychotic for the schizophrenia symptoms.

Purity: >98% Purity: 99.64% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Iloperidone hydrochloride hydrochloride (HP 873 hydrochloride) Cat. No.: HY-17410A (HSR803) Cat. No.: HY-B0732

Iloperidone hydrochloride (HP 873 hydrochloride) Itopride hydrochloride (HSR803), a is a D2/5-HT2 receptor antagonist. Iloperidone gastroprokinetic Benzamide (HY-Z0283) derivative, hydrochloride is an atypical antipsychotic for the is an inhibitor of acetylcholinesterase (AChE) and schizophrenia symptoms. dopamine D2 receptor.

Purity: >98% Purity: 99.95% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 500 mg, 1 g, 5 g

JNJ-37822681 dihydrochloride Keto Ziprasidone Cat. No.: HY-111066A Cat. No.: HY-100648

JNJ-37822681 dihydrochloride is a potent, Keto Ziprasidone is an impurity of Ziprasidone. specific, centrally active, fast-dissociating Ziprasidone, an antipsychotic agent, is a combined dopamine D2 receptor antagonist with a moderate 5-HT (serotonin) and dopamine receptor antagonist. binding affinity for the dopamine D2L receptor

(Ki =158 nM), which has potential for the treatment of schizophrenia and . Purity: ≥98.0% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg Size: 1 mg, 5 mg

L-741626 L-745870 Cat. No.: HY-101348 Cat. No.: HY-14325

L-741626 is a selective D2 dopamine receptor L-745870 is a potent, selective, brain-penetrant antagonist, with the Ki values of 2.4, 100 and 220 and orally active dopamine D4 receptor nM for human D2, D3 and D4 receptors respectively. antagonist with a Ki of 0.43 nM.

Purity: 98.72% Purity: 99.88% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg Size: 5 mg, 10 mg

www.MedChemExpress.com 11

L-745870 hydrochloride L-745870 trihydrochloride Cat. No.: HY-14325B Cat. No.: HY-14325A

L-745870 hydrochloride is a potent, selective, L-745870 trihydrochloride is a potent, selective,

brain-penetrant and orally active dopamine D4 brain-penetrant and orally active dopamine D4

receptor antagonist with a Ki of 0.43 nM. receptor antagonist with a Ki of 0.43 nM.

Purity: 99.88% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg Size: 1 mg, 5 mg

L-DOPA (Levodopa; 3,4-Dihydroxyphenylalanine) Cat. No.: HY-N0304 (Methotrimeprazine) Cat. No.: HY-B1693

L-DOPA (Levodopa) is an orally active metabolic Levomepromazine (Methotrimeprazine) is an orally precursor of dopamine. L-DOPA available neuroleptic agent, which is commonly can cross the blood-brain barrier and is converted used to relieve nausea and vomiting in palliative into dopamine in the brain. L-DOPA has care settings. anti-allodynic effects and the potential for Parkinson's disease. Purity: 99.97% Purity: 99.98% Clinical Data: Launched Clinical Data: Launched Size: 200 mg, 1 g Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Levosulpiride tosylate (RV-12309; S-(-)-) Cat. No.: HY-B1059 (ITI-007 tosylate) Cat. No.: HY-19733

Levosulpiride (RV-12309) is the (S)-enantiomer of Lumateperone tosylate (ITI-007 tosylate) is a sulpiride, which is a D2 receptor a antagonist, an 5-HT2A receptor antagonist (Ki = 0.54 nM), a atypical antipsychotic drug of the benzamide partial agonist of presynaptic D2 receptors and an class. antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a SERT blocker (Ki = 61 nM).

Purity: 99.91% Purity: 99.42% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Lurasidone Hydrochloride (SM-13496) Cat. No.: HY-B0032A (SM-13496 Hydrochloride) Cat. No.: HY-B0032

Lurasidone (SM-13496) is an antagonist of both Lurasidone (Hydrochloride) (SM-13496

dopamine D2 and 5-HT7 with IC50s of 1.68 (Hydrochloride)) is an antagonist of both

and 0.495 nM, respectively. Lurasidone (SM-13496) dopamine D2 and 5-HT7 with IC50s of 1.68

is also a partial agonist of 5-HT1A receptor and 0.495 nM, respectively.

with an IC50 of 6.75 nM.

Purity: 99.49% Purity: 99.87% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

LY3154207 Cat. No.: HY-128770 Cat. No.: HY-B1033

LY3154207 is a potent, subtype selective, and Metergoline is a serotonin (5-HT) receptor and

orally available human dopamine D1 receptor dopamine receptors antagonist, with pKis of

positive allosteric modulator (PAM) with minimal 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and

allosteric agonist activity (EC50=3 nM). 5-HT2C, respectively. Metergoline is a

high-affinity ligand for the h5-HT7 receptor,

with a Ki of 16 nM. Purity: 99.81% Purity: 99.74% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 50 mg, 100 mg

12 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

ML417 hydrochloride Cat. No.: HY-136390 (EN-1733A) Cat. No.: HY-B1017

ML417 is a selective and brain penetrant D3 Molindone hydrochloride (EN-1733A) is a dopamine receptor (D3R) agonist, with an EC50 therapeutic antipsychotic, used in the treatment of 38 nM. ML417 potently promotes D3R-mediated of schizophrenia, works by blocking the effects of β-arrestin translocation, G protein mediated dopamine in the brain, leading to diminished signaling, and pERK phosphorylation with minimal psychoses. effects on other GPCR-mediated signaling. Purity: 99.65% Purity: 99.50% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

MPTP hydrochloride NEO 376 Cat. No.: HY-15608 (SPI-376) Cat. No.: HY-101583

MPTP hydrochloride is a brain penetrant NEO 376 is a selective modulator of 5-HT1 dopamine neurotoxin, inducing Parkinson’s receptor, GABA receptor and dopamine Disease. MPTP hydrochloride, a precusor of receptor, with anti-psychotic actively. MPP+, induces apoptosis.

Purity: 99.54% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Neuromedin N NGB 2904 hydrochloride (Neuromedin N (rat, mouse, porcine, canine)) Cat. No.: HY-P0079 Cat. No.: HY-12697A

Neuromedin N is a potent modulator of dopamine D2 NGB 2904 hydrochloride is a potent, selective, receptor agonist binding in rat neostriatal orally active and brain-penetrated antagonist of membranes. dopamine D3 receptor, with a Ki of 1.4 nM.

Purity: 99.91% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg

NMI 8739 Nomifensine Cat. No.: HY-101540 ((±)-Nomifensin) Cat. No.: HY-B1110

NMI 8739 is a dopamine D2 autoreceptor Nomifensine is a norepinephrine-dopamine reuptake agonist, which is an amine conjugate of the DHA inhibitor, increases the amount of synaptic carrier and the neurotransmitter dopamine. norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

Purity: 97.53% Purity: 98.93% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 50 mg, 100 mg

Nomifensine maleate NRA-0160 ((±)-Nomifensine maleat) Cat. No.: HY-B1110A Cat. No.: HY-101641

Nomifensine maleate is a selective inhibitor of NRA-0160 is a selective dopamine D4 receptor dopamine uptake, used in adult attention deficit antagonist, with a Ki value of 0.48 nM and with disorder. negligible affinity for dopamine D2 receptor

(Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat

5-HT2A receptor (Ki: 180 nM) and rat α1

adrenoceptor (Ki: 237 nM). Purity: 99.67% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg, 100 mg Size: 1 mg, 5 mg

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Nuciferine Cat. No.: HY-N0049 (R79598) Cat. No.: HY-101094

Nuciferine is an antagonist at 5-HT2A (IC50=478 Ocaperidone is an effective antipsychotic agent,

nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 acting as a potent 5-HT2 and dopamine D2

μM), an at 5-HT7 (IC50=150 nM), antagonist, and a 5-HT1A agonist, with Kis of

a partial agonist at D2 (EC50=64 nM), D5 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for

(EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an 5-HT2, a1- receptor, dopamine D2,

agonist at 5-HT1A (EC50=3.2 μM) and… histamine H1 and a2-adrenergic… Purity: 99.66% Purity: 99.63% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Odapipam (NNC 756) Cat. No.: HY-129059 (LY170053) Cat. No.: HY-14541

Odapipam (NNC 756) is a selective, high affinity Olanzapine (LY170053) is a selective

and benzazepine dopamine D1 receptor antagonist with high affinity binding to serotonin

antagonist with a Kd of 0.18 nM. Odapipam is H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5

also a superior positron emission tomography (PET) nM, respectively), dopamine D1-4 (Ki=11 to 31

radiotracer. nM), muscarinic M1-5 (Ki=1.9-25 nM), and

adrenergic α1 receptor (Ki=19 nM). Purity: ≥99.0% Purity: 99.89% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg Size: 10 mM × 1 mL, 50 mg, 100 mg, 500 mg

Olanzapine D3 ONC206 (LY170053 D3) Cat. No.: HY-14541S Cat. No.: HY-135147

Olanzapine D3 (LY170053 D3) is the deuterium ONC206 is an analogue of TRAIL inducer ONC201. labeled Olanzapine. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity.

Purity: 99.09% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Org-10490 hydrobromide Cat. No.: HY-U00077 (6-Hydroxydopamine hydrobromide; 6-OHDA hydrobromide)Cat. No.: HY-B1081A

Org-10490 is an antagonist of dopamine D1 Oxidopamine hydrobromide (6-OHDA hydrobromide), receptor and dopamine D2 receptor, used for an antagonist of the neurotransmitter the treatment for psychiatric disease. dopamine, is a widely used neurotoxin that selectively destroys dopaminergic neurons.

Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 50 mg, 100 mg, 200 mg, 500 mg, 1 g

Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride) Cat. No.: HY-B1081 (9-Hydroxyrisperidone) Cat. No.: HY-A0019

Oxidopamine hydrochloride (6-OHDA hydrochloride), Paliperidone (9-Hydroxyrisperidone), the major an antagonist of the neurotransmitter active metabolite of , is a dopamine dopamine, is a widely used neurotoxin that D2 antagonist and 5-HT2A antagonist. selectively destroys dopaminergic neurons. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1- receptors. Purity: ≥98.0% Purity: 99.87% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg

14 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Paliperidone palmitate (9-Hydroxyrisperidone palmitate) Cat. No.: HY-A0019A (SLV-308; DU-126891) Cat. No.: HY-14958

Paliperidone palmitate (9-Hydroxyrisperidone Pardoprunox (SLV-308) is a partial dopamine D2 palmitate), an atypical long-acting antipsychotic and D3 receptor partial agonist and a serotonin agent, is an ester prodrug of Paliperidone. 5-HT1A receptor agonist, with pEC50s of 8, 9.2, Paliperidone is a dopamine antagonist and and 6.3, respectively. 5-HT2A antagonist of the atypical antipsychotic class. Purity: 98.16% Purity: >98% Clinical Data: Launched Clinical Data: Phase 3 Size: 10 mM × 1 mL, 10 mg Size: 1 mg, 5 mg

Pardoprunox hydrochloride PD 168568 dihydrochloride (SLV-308 hydrochloride; DU-126891 hydrochloride) Cat. No.: HY-14958A Cat. No.: HY-103407A

Pardoprunox (SLV-308) hydrochloride is a partial PD 168568 dihydrochloride is an orally active and dopamine D2 and D3 receptor partial agonist selective D4 dopamine receptor antagonist, with and a serotonin 5-HT1A receptor agonist, with a Ki of 8.8 nM. pEC50s of 8, 9.2, and 6.3, respectively.

Purity: 98.24% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

PD-168077 maleate Pentiapine Cat. No.: HY-21098A (CGS 10746) Cat. No.: HY-100143

PD-168077 maleate is a selective dopamine D4 Pentiapine (CGS 10746) is a dopamine release receptor agonist, with a Ki of 9 nM. inhibitor without binding to synaptic dopamine receptor sites.

Purity: 98.44% Purity: 99.74% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg, 10 mg

Pergolide mesylate Pericyazine ( methanesulfonate; LY127809) Cat. No.: HY-13720A (Propericiazine; RP 8909) Cat. No.: HY-14263

Pergolide mesylate (Pergolide methanesulfonate), Pericyazine (Propericiazine) is a first-generation an Ergoline derivative, is a potent and orally antipsychotic agent that is used as an adjunct to active dopamine D1 and D2 receptors the short-term management of severe anxiety states agonist. Pergolide mesylate can be used for and psychosis. Pericyazine is a selective Parkinson's disease and D2-dopamine receptor antagonist. research. Purity: 99.93% Purity: 99.83% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Perospirone hydrochloride (SM-9018 free base) Cat. No.: HY-B0731A (SM-9018) Cat. No.: HY-B0731

Perospirone (SM-9018 free base) is an orally Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) active antagonist of 5-HT2A receptor (Ki of 0.6 and dopamine D2 receptor (Ki=1.4 nM), and nM) and dopamine D2 receptor (Ki of 1.4 nM). also a partial agonist of 5-HT1A receptor Perospirone hydrochloride is also a partial

(Ki=2.9 nM). agonist of 5-HT1A receptor (Ki of 2.9 nM).

Purity: 99.51% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 15

Perphenazine D8 Dihydrochloride Cat. No.: HY-A0077 Cat. No.: HY-A0077AS

Perphenazine is a drug, Perphenazine D8 Dihydrochloride is the deuterium

inhibits 5-HT2Areceptor, Alpha-1A adrenergic labeled Perphenazine, which is a typical receptor, /D3, D2L receptor, antipsychotic drug(5-HT, Dopamine receptor

and Histamine H1 receptor, with Ki values of ligand). 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

Purity: 99.72% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 1 mg, 5 mg

PF-06256142 PF-592379 Cat. No.: HY-119943 Cat. No.: HY-U00400

PF-06256142 is a potent, selective, CNS-penetrant PF-592379 is a potent dopamine D3 receptor

and orally active agonist of the D1 receptor, agonist with an EC50 of 21 nM.

with an EC50 and Ki of 33 nM and 12 nM, respectively. PF-06256142 has the potential for the research of schizophrenia and Parkinson's disease. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

PF2562 Cat. No.: HY-120879 (R6238) Cat. No.: HY-12987

PF2562 (Example 6), a dopamine D1 ligand, Pimozide is a dopamine receptor antagonist,

ascts as a dopamine D1 agonist or partial with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine agonist. PF2562 binds to human D1 receptor with a D2, D3 and D1 receptors, respectively, and also

Ki of 113 nM. PF2562 exhibits activity against has affinity at α1-adrenoceptor, with a Ki of 39

human D1 cAMP with an EC50 of 568 nM in HTRF nM; Pimozide also inhibits STAT3 and STAT5. assay. Purity: >98% Purity: 99.88% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 50 mg

Pimozide D4 (R6238 D4) Cat. No.: HY-12987S (Floropipamide; McN-JR 3345; R 3345) Cat. No.: HY-100703

Pimozide D4 (R6238 D4) is a deuterium labeled Pipamperone (Floropipamide; McN-JR 3345; R 3345)

Pimozide. is a high-affinity antagonist of 5-HT2A

receptor (pKi=8.2) and D4 receptor (pKi=8.0)

and a low-affinity antagonist of D2 receptor

(pKi=6.7).

Purity: >98% Purity: 99.89% Clinical Data: Phase 4 Clinical Data: Phase 3 Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg

Piperidine-MO-1 Cat. No.: HY-19845A Cat. No.: HY-12707

Piperidine-MO-1 is a modulator of dopamine Piribedil is a dopamine D2 receptor (D2R) receptor extracted from patent WO/2005/121087A1, agonist which also displays antagonist property at

compound example 2; exhibits an ED50 of 68 hα1A-adrenoceptor (hα1A-AR). μmol/kg on increase of DOPAC in the rat striatum.

Purity: >98% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

16 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Piribedil D8 PNU-177864 hydrochloride (ET-495 D8) Cat. No.: HY-12707S Cat. No.: HY-103406A

Piribedil D8 (ET-495 D8) is the deuterium labeled PNU-177864 hydrochloride is a potent, selective

Piribedil, which is an antiparkinsonian agent. and orally active dopamine D3 receptor antagonist. PNU-177864 hydrochloride is structurally consistent with a cationic amphiphilic drug (CAD) and induces phospholipidosis in vivo. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Pramipexole Pramipexole dihydrochloride Cat. No.: HY-B0410 Cat. No.: HY-17355

Pramipexole is a selective and blood-brain barrier Pramipexole dihydrochloride is a selective and (BBB) penetrant dopamine D2-type receptor blood-brain barrier (BBB) penetrant dopamine agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and D2-type receptor agonist, with Kis of 2.2 nM, 3.9

1.3 nM for D2-type receptor, D2, D3 and D4 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, receptors, respectively. D3 and D4 receptors, respectively.

Purity: 99.88% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 500 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Pramipexole dihydrochloride hydrate Cat. No.: HY-B0410A (ACR16; ASP2314; FR310826) Cat. No.: HY-10684

Pramipexole dihydrochloride hydrate is a selective Pridopidine, a dopamine (DA) stabilizer, acts and blood-brain barrier (BBB) penetrant as a low affinity dopamine D2 receptor (D2R) dopamine D2-type receptor agonist, with Kis of antagonist. Pridopidine exerts high affinity

2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type towards sigma 1 receptor (S1R) with Ki receptor, D2, D3 and D4 receptors, between 70 and 80 nM, which is ~100× higher than respectively. its affinity toward D2R. Purity: ≥98.0% Purity: 99.77% Clinical Data: Launched Clinical Data: Phase 3 Size: 10 mM × 1 mL, 10 mg, 50 mg Size: 10 mM × 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Propionylpromazine hydrochloride (Propiopromazine hydrochloride) Cat. No.: HY-W040146 (ICI204636) Cat. No.: HY-14544

Propionylpromazine hydrochloride (Propiopromazine Quetiapine (ICI204636) is a 5-HT receptors hydrochloride), a dopamine receptor D2 (DRD2) agonist with a pEC50 of 4.77 for human 5-HT1A antagonist, can be used in the research of receptor. Quetiapine is a dopamine receptor

Parkinson disease. antagonist with a pIC50 of 6.33 for human D2 receptor.

Purity: 99.38% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Quetiapine D4 fumarate Quetiapine D4 hemifumarate Cat. No.: HY-B0031S Cat. No.: HY-B0031S1

Quetiapine D4 fumarate is the deuterium labeled Quetiapine D4 hemifumarate is the deuterium Quetiapine fumarate. Quetiapine fumarate is a 5-HT labeled Quetiapine hemifumarate. Quetiapine receptors agonist and a dopamine receptor hemifumarate is a 5-HT receptors agonist and a antagonist. Antidepressant and effects. dopamine receptor antagonist. Antidepressant and anxiolytic effects.

Purity: ≥98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 5 mg, 10 mg, 20 mg

www.MedChemExpress.com 17

Quetiapine hemifumarate hydrochloride Cat. No.: HY-B0031 (CV205-502 hydrochloride) Cat. No.: HY-13736A

Quetiapine hemifumarate is a 5-HT receptors Quinagolide hydrochloride is a selective dopamine

agonist with a pEC50 of 4.77 for human 5-HT1A D2 receptor agonist, also is a receptor. Quetiapine hemifumarate is a inhibitor.

dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor.

Purity: 98.24% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 5 mg, 10 mg, 50 mg, 100 mg

Quinpirole Hydrochloride ((-)-LY 171555) Cat. No.: HY-B1752A Cat. No.: HY-103414

Quinpirole Hydrochloride ((-)-LY 171555) is a Raclopride is a dopamine D2/D3 receptor

high-affinity agonist of dopamine D2/D3 antagonist, which binds to D2 and D3

receptor. receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very

low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively. Purity: 99.43% Purity: 98.88% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg

Risperidone Risperidone hydrochloride (R 64 766) Cat. No.: HY-11018 (R 64 766 hydrochloride) Cat. No.: HY-11018A

Risperidone is a serotonin 5-HT2 receptor Risperidone hydrochloride (R 64 766 hydrochloride)

blocker, P-Glycoprotein inhibitor and potent 5-HT2 receptor blocker, P-Glycoprotein inhibitor

dopamine D2 receptor antagonist, with Kis of and potent dopamine D2 receptor antagonist,

4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine

respectively. D2 receptor, respectively.

Purity: 98.01% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 500 mg Size: 1 mg, 5 mg

Risperidone mesylate (R 64 766 mesylate) Cat. No.: HY-11018B (R 55667) Cat. No.: HY-10791

Risperidone mesylate(R 64 766 mesylate) is a Ritanserin (R 55667) is a highly potent,

serotonin 5-HT2 receptor blocker, P-Glycoprotein relatively selective, orally active, long acting

inhibitor and potent dopamine D2 receptor antagonist of 5-HT2 receptor, with an IC50 of

antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A 0.9 nM, less active on Histamine H1, Dopamine

and dopamine D2 receptor, respectively. D2, Adrenergic α1, Adrenergic α2 receptors.

Purity: >98% Purity: 99.78% Clinical Data: Launched Clinical Data: Phase 2 Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg

Ro 10-5824 dihydrochloride hydrochloride Cat. No.: HY-101384A (SKF 101468 hydrochloride) Cat. No.: HY-B0623A

Ro 10-5824 dihydrochloride is a selective Ropinirole hydrochloride is a potent D3/D2

dopamine D4 receptor partial agonist, with Ki receptor agonist with a Ki of 29 nM for D2

of 5.2 nM. receptor. Ropinirole hydrochloride has pEC50s of

7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride

has no affinity for the D1 receptors. Purity: 99.93% Purity: 99.91% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg

18 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Rotigotine Rotigotine D7 Hydrochloride (N-0437; N-0923) Cat. No.: HY-75502 (N-0923 D7 Hydrochloride) Cat. No.: HY-A0007S

Rotigotine (N-0437; N-0923) is a full agonist of Rotigotine (N-0923) D7 Hydrochloride is the dopamine receptor, a partial agonist of the deuterium labeled Rotigotine(N-0923), which is a 5-HT1A receptor, and an antagonist of the dopamine D2 and D3 receptor agonist.

α2B-, with Kis of 0.71nM, 4-15nM, and 83nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine… Purity: 99.98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Rotigotine Hydrochloride Rotundine (N-0923 Hydrochloride) Cat. No.: HY-A0007 ((-)-Tetrahydropalmatine; L-Tetrahydropalmatine) Cat. No.: HY-N0096

Rotigotine Hydrochloride (N-0923 Hydrochloride) is Rotundine is an antagonist of dopamine D1, D2 a full agonist of dopamine receptor, a partial and D3 receptors with IC50s of 166 nM, 1.4 μM agonist of the 5-HT1A receptor, and an and 3.3 μM, respectively. Rotundine is also an antagonist of the α2B-adrenergic receptor, with Ki antagonist of 5-HT1A with an IC50 of 370 nM. of 0.71nM, 4-15nM, and 83nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine… Purity: 99.47% Purity: 99.88% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg Size: 10 mM × 1 mL, 50 mg

Sarizotan SB-277011 (EMD 128130) Cat. No.: HY-100820 (SB-277011A) Cat. No.: HY-10847

Sarizotan (EMD 128130) is an orally active SB-277011 is a potent and delective dopamine D3 serotonin 5-HT1A receptor and dopamine receptor antagonist (pKi values are 8.0, 6.0, 5.0 receptor agonist. and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

SB-277011 dihydrochloride SB-277011 hydrochloride (SB-277011A dihydrochloride) Cat. No.: HY-10847A (SB-277011A hydrochloride) Cat. No.: HY-10847B

SB-277011 dihydrochloride (SB-277011A SB-277011 hydrochloride (SB-277011A hydrochloride) dihydrochloride) is a potent, selective, orally is a potent, selective, orally bioavailable and bioavailable and brain penetrate dopamine D3 brain penetrate dopamine D3 receptor receptor antagonist, with pKis of 8.0, 6.0, (D3R) antagonist with Ki values of

<5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D 10.7 nM and 11.2 nM at rodent receptors, respectively. and human D3R, respectively. Purity: >98% Purity: 98.22% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

SB269652 SCH-23390 hydrochloride Cat. No.: HY-12324 (R-(+)-SCH-23390 hydrochloride) Cat. No.: HY-19545A

SB269652 is the first drug-like allosteric SCH-23390 hydrochloride (R-(+)-SCH-23390 modulator of the dopamine D2 receptor (D2R); a new hydrochloride) is a potent and selective chemical probe that can differentiate D2R monomers dopamine D1-like receptor antagonist with Kis from dimers or oligomers depending on the observed of 0.2 nM and 0.3 nM for the D1 and D5 . receptor, respectively.

Purity: >98% Purity: 99.31% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 19

SCH-23390 maleate (R-(+)-SCH-23390 maleate) Cat. No.: HY-108400 (Lu 23-174) Cat. No.: HY-14543

SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a Sertindole, a neuroleptic, is one of the newer

potent and selective dopamine D1-like receptor antipsychotic available. Target:

antagonist with Kis of 0.2 nM and 0.3 nM for the Multi-target In vitro studies showed that

D1 and D5 receptor, respectively. sertindole exerts a potent antagonism at serotonin 5-HT2A, 5-HT2C, dopamine D2, and αl adrenergic receptors. Purity: >98% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

SKF 38393 hydrobromide SKF 38393 hydrochloride Cat. No.: HY-12237 ((±)-SKF-38393 hydrochloride; SKF-38393A) Cat. No.: HY-12520A

SKF 38393 hydrobromide is a selective agonist of SKF 38393 hydrochloride is a selective agonist of

the dopamine D1 receptor (D1DR) with an IC50 the dopamine D1 receptor (D1DR) with an IC50 of 110 nM. of 110 nM.

Purity: >98% Purity: 99.44% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg

SKF-82958 SKF-82958 hydrobromide ((±)-SKF-82958; Chloro-APB) Cat. No.: HY-10435 ((±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide) Cat. No.: HY-10435A

SKF-82958 ((±)-SKF 82958) is a dopamine D1 SKF-82958 ((±)-SKF 82958) hydrobromide is a

receptor full agonist (K0.5=4 nM), displays dopamine D1 receptor full agonist (K0.5=4

selective for D1 over D2 receptors (K0.5=73 nM). nM), displays selective for D1 over D2 receptors

SKF-82958 induces dopamine D1 receptor-dependent (K0.5=73 nM). SKF-82958 hydrobromide induces adenylate cyclase activity in rat striatal dopamine D1 receptor-dependent adenylate cyclase

membranes (EC50=491 nM). activity in rat striatal membranes (EC50=491 nM). Purity: >98% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

SKF-83566 SKF-83566 hydrobromide Cat. No.: HY-103430A Cat. No.: HY-103430

SKF-83566 is a potent, blood-brain permeable SKF-83566 hydrobromide is a and orally active D1-like dopamine receptor potent, blood-brain permeable and orally (D1DR) antagonist and a weaker competitive active D1-like dopamine receptor

antagonist at the vascular 5-HT2 receptor (D1DR) antagonist and a weaker competitive

(Ki=11 nM). antagonist at the vascular 5-HT2 receptor

(Ki=11 nM). Purity: 99.86% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg Size: 5 mg, 10 mg, 25 mg

Sonepiprazole hydrochloride (PNU-101387G; U-101387G) Cat. No.: HY-14328 (Spiroperidol hydrochloride) Cat. No.: HY-B1371A

Sonepiprazole (PNU-101387G) is a selective D4 Spiperone hydrochloride (Spiroperidol

dopamine antagonist with Kis of 3.6, 10.1, hydrochloride) is a selective dopamine D2

5147, and 7430 nM for rD4-Dopamine, receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM,

hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5

receptors, respectively. receptors, respectively) and 5-HT2A/5-HT1A

receptor (Kis of 1 nM/49 nM)… Purity: >98% Purity: ≥99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mg

20 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Spiramide ST-836 (AMI-193) Cat. No.: HY-100971 Cat. No.: HY-15238

Spiramide (AMI-193) is a potent and selective ST-836 is a dopamine receptor ligand; antagonist of 5-HT2 and dopamine D2 Antiparkinsonian agent. receptor, with Kis of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2 versus 5-HT1C (Ki=4300 nM) receptors. Purity: 98.81% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

ST-836 hydrochloride Sulpiride Cat. No.: HY-15238A Cat. No.: HY-B1019

ST-836 hydrochloride (compound 34) is a potent Sulpiride is a D2 receptor a antagonist, an dopamine receptor ligand with Ki values of 4.5 atypical antipsychotic drug of the benzamide nM, 132 nM for D3 and D2, respectively. ST-836 class, used mainly in the treatment of psychosis hydrochloride has the potential for Parkinson’s associated with schizophrenia and major depressive disease. disorder, and sometimes used in low dosage to treat anxiety and mild depression. Purity: 98.11% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg Size: 10 mM × 1 mL, 100 mg

Sultopride hydrochloride (LIN-1418) Cat. No.: HY-42849 (LIN-1418 hydrochloride) Cat. No.: HY-42849A

Sultopride (LIN-1418) is a selective antagonist of Sultopride hydrochloride (LIN-1418 hydrochloride) dopamine D2 receptor. is a selective antagonist of dopamine D2 receptor.

Purity: >98% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg

Sumanirole maleate (U-95666E; PNU-95666) Cat. No.: HY-70081A (B-HT 920) Cat. No.: HY-A0040

Sumanirole maleate (U-95666E; PNU-95666E) is a Talipexole (B-HT920) is a dopamine agonist that highly selective D2 receptor full agonist with has been proposed as an antiparkinsonian agent. an ED50 of about 46 nM. Sumanirole was developed Target: Dopamine Receptor B-HT920 is a selective for the treatment of Parkinson's disease and alpha 2-adrenoceptor agonist. restless leg syndrome.

Purity: ≥98.0% Purity: >98% Clinical Data: Phase 3 Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Talipexole dihydrochloride Tavapadon (B-HT 920 dihydrochloride) Cat. No.: HY-A0008 (PF-06649751; CVL-751) Cat. No.: HY-119486

Talipexole dihydrochloride (B-HT 920 Tavapadon (PF-06649751) is an orally active and dihydrochloride) is a dopamine D2 receptor highly selective dopamine D1/D5 receptor agonist, α2-adrenoceptor agonist and 5-HT3 partial agonist. Tavapadon is effective in receptor antagonist, which displays enabling movement and reducing disability and has antiParkinsonian activity. the potential for Parkinson's disease.

Purity: 99.88% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 21

Tetrahydroberberine Tetrahydropalmatine () Cat. No.: HY-N0925 (DL-Tetrahydropalmatine) Cat. No.: HY-N0300

Tetrahydroberberine is an isoquinoline alkaloid Tetrahydropalmatine, an active component isolated isolated from corydalis tuber; has micromolar from corydalis, possesses effects. affinity for dopamine D(2) (pK(i) = 6.08) and Tetrahydropalmatine acts through inhibition of 5-HT(1A) (pK(i) = 5.38) receptors but moderate to amygdaloid release of dopamine to inhibit an no affinity for other relevant serotonin receptors epileptic attack in rats. (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4);… Purity: 99.70% Purity: 99.16% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Tetrahydropalmatine hydrochloride dimaleate (DL-Tetrahydropalmatine hydrochloride) Cat. No.: HY-N0300A Cat. No.: HY-B1794A

Tetrahydropalmatine hydrochloride Thiethylperazine dimaleate is a phenothiazine (DL-Tetrahydropalmatine hydrochloride), an active derivate, and an orally active dopamine component isolated from corydalis, possesses D2-receptor and histamine H1-receptor analgesic effects. antagonist. Thiethylperazine dimaleate is also a slective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Thioridazine hydrochloride hydrochloride Cat. No.: HY-B0965 Cat. No.: HY-B1196

Thioridazine hydrochloride is an antipsychotic Tiapride hydrochloride is a drug that selectively drug, used in the treatment of schizophrenia and blocks D2 and D3 dopamine receptors in the brain. psychosis, shows D4 selectivity or serotonin It is used to treat a variety of neurological and antagonism. psychiatric disorders including , withdrawal syndrome.

Purity: 99.93% Purity: 99.82% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 100 mg

Triflupromazine hydrochloride D6 Cat. No.: HY-B0909 (Ro 2-9578 free base D6) Cat. No.: HY-12751S

Triflupromazine hydrochloride is an antipsychotic Trimethobenzamide D6 is deuterium labeled , which are Dopamine D1/D2 receptor Trimethobenzamide. Trimethobenzamide is a blocker

antagonists. of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

Purity: 99.94% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg Size: 1 mg, 5 mg

Trimethobenzamide hydrochloride U91356 (Ro 2-9578) Cat. No.: HY-12751A Cat. No.: HY-U00227

Trimethobenzamide hydrochloride is a blocker of U91356 is a dopamine receptor agonist.

the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

Purity: 99.80% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg Size: 1 mg, 5 mg

22 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

UCSF924 Cat. No.: HY-125751 ((±)-Veralipride; LIR166) Cat. No.: HY-101797

UCSF924 is a potent and specific dopamine D4 Veralipride is a D2 receptor antagonist. It is an receptor (DRD4) partial agonist with a EC50 of alternative antidopaminergic treatment for

4.2 nM. UCSF924 has a high-affinity with a Ki menopausal symptoms. value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant.

Purity: 99.53% Purity: 99.57% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg Size: 10 mM × 1 mL, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

WAY-100635 WAY-100635 Maleate Cat. No.: HY-10349 Cat. No.: HY-10349A

WAY-100635 is a potent and selective 5-HT1A WAY-100635 maleate is a potent and selective

Receptor antagonist with a pIC50 of 8.87, an 5-hydroxytryptamine 1A (5-HT1A) receptor apparent pA2 of 9.71. WAY-100635 is a potent and antagonist with an IC50 value of 0.91 nM and Ki selective 5-hydroxytryptamine 1A (5-HT1A) value of 0.39 nM. WAY-100635 maleate has pIC50 receptor antagonist with an IC50 value of 0.91 nM values for 5-HT1A and α1-adrenergic receptors of and Ki value of 0.39 nM. 8.9 and 6.6, respectively. Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Xaliproden hydrochloride Ziprasidone (SR57746A; SR57746 hydrochloride) Cat. No.: HY-14604 (CP-88059) Cat. No.: HY-14542

Xaliproden hydrochloride (SR57746A) is a potent, Ziprasidone, an antipsychotic agent, is a combined selective and orally active agonist of 5-HT1A 5-HT (serotonin) and dopamine receptor receptor, shows a high affinity for 5-HT1A antagonist. Ziprasidone has high affinity for rat specific binding sites in the rat hippocampus (Ki: 3.4 nM)/human (2.5 nM) 5-HT1A receptors,

(IC50=3 nM). 5-HT2A (0.42 nM), and dopamine D2 receptors (4.8 nM). Purity: >98% Purity: 98.69% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Ziprasidone Ziprasidone D8 (Ziprasidone Impurity C; Ziprasidone open ring impurity) Cat. No.: HY-131255 (CP-88059 D8) Cat. No.: HY-14542S

Ziprasidone amino acid (Ziprasidone Impurity C) is Ziprasidone D8 is deuterium labeled Ziprasidone, an impurity of Ziprasidone. Ziprasidone is a which is a combined 5-HT (serotonin) and dopamine combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects receptor antagonist. Ziprasidone exhibits potent of antipsychotic activity. effects of antipsychotic activity .

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Ziprasidone hydrochloride Ziprasidone hydrochloride monohydrate (CP-88059 hydrochloride) Cat. No.: HY-14542A (CP 88059 hydrochloride monohydrate) Cat. No.: HY-17407

Ziprasidone (CP-88059) hydrochloride, an Ziprasidone (CP 88059) hydrochloride monohydrate, antipsychotic agent, is a combined 5-HT an antipsychotic agent, is an orally active (serotonin) and dopamine receptor antagonist. combined 5-HT (serotonin) and dopamine receptor antagonist.

Purity: >98% Purity: 99.83% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

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Zuclopenthixol ((Z)-Clopenthixol) Cat. No.: HY-A0163

Zuclopenthixol is a derivative which acts as a mixed dopamine D1/D2 receptor antagonist.

Purity: 98.13% Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg

24 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]