damon runyon cancer research foundation 2012 Annual Report
How do WE SPOT AN INNOVATOR?
241798_SS_R3.indd 1 11/5/12 8:43 PM Everyone uses the word “innovation” today—CEOs, How do WE SPOT politicians, advertisers. There is even a how-to book called “The Little Black Book of Innovation.” As if all you AN INNOVATOR? need to do is read a book to become an innovator.
Actual innovation is extremely rare. It requires a unique individual with the vision to see things no one has seen before, the passion to push through overwhelming obstacles and the audacity to pursue ideas that could very well fail.
At the Damon Runyon Cancer Research Debbie and Andy Rachleff Foundation, we believe that young WillingNess scientists with vision, passion and audacity will be the ones to to Fail make the biggest breakthroughs against cancer.
In 2008, we launched the Damon Runyon-Rachleff Innovation Award in partnership with two visionary philanthropists, Debbie and Andy Rachleff. In stark contrast to traditional research funding, which supports safe bets and incremental studies, the goal of the Innovation Award is to encourage brilliant young cancer researchers to pursue high-risk ideas with high-impact potential.
In this year’s annual report, we profile three young Innovators and share insights into how they were selected by members of our Innovation Award Selection Committee, who became breakthrough scientists themselves early in their careers.
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241794_SS_R1.indd 2 10/27/12 12:48 AM How do WE SPOT AN INNOVATOR?
Vision Passion
WillingNess Courage to Fail
INTELLIGENCE Audacity
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241798_SS_R3.indd 3 11/5/12 7:46 PM The Damon Runyon- Rachleff Innovation Award is based on three core principles:
Youth drives innovation.
It takes an innovator to know an innovator.
Failure is an option. The Innovation Award has been a remarkable success and provides a model for empowering young scientists to think differently.
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241798_SS_R3.indd 5 11/5/12 7:30 PM “The Rachleffs really felt that we would recognize ‘fire in the belly’ much better in person than on paper. They proved to be absolutely right about that.”
Ronald Levy, MD
Ronald Levy, MD Professor, Division of Oncology, Stanford University School of Medicine Chair, Damon Runyon-Rachleff Innovation Award Committee Breakthrough discovery led to the development of Rituxan, the first monoclonal antibody therapy for cancer
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241794_SS_R1.indd 6 10/27/12 12:51 AM Doing What “Can’t Be Done” David G. Kirsch, MD, PhD Damon Runyon-Rachleff Innovator Associate Professor of Radiation Oncology, Duke University School of Medicine
When Ronald Levy, MD, first sat down The initial doubts did not dissuade David. to discuss an “innovation award” with Damon “Part of innovation,” he says, "is figuring out Runyon President and CEO Lorraine Egan and ways to overcome obstacles when people say venture capitalist Andy Rachleff, he had his ‘this can’t be done’ or ‘it’s too hard to do.’” doubts about how innovative the proposals While treating sarcoma patients, David found would be. “By definition, cancer researchers are his passion: sparing patients from unnecessary not doing something in their own garage. They radiation. “It was clear to me that a lot, even work in established academic institutions.” the majority, of patients were not benefiting Having spent years spotting and funding from the adjuvant radiation, just enduring the innovative ideas in the private sector, Andy toxicity,” he says. was more confident. “He encouraged us to take He dreamed of new imaging technology risks on projects that were not funded by the that surgeons could use in the operating room. mainstream,” Ron recalls, “ideas that would be Patients would be injected with a molecular out-of-the-box and have bigger impact in the agent that fluoresced only in the cancer cells, long run.” which the device would detect immediately. “I asked, ‘How do we find these people?’ and After meeting with engineers at MIT who had Andy said, ‘Don’t worry; they’ll find you. Just put confidence in his vision, David applied for a out the word.’ So, we put together a committee Damon Runyon-Rachleff Innovation Award. of scientists who had been innovators in their “What was amazing about the own careers. The idea being that it takes Innovation Award was that Damon Runyon one to know one.” and the Rachleffs were willing to take One of the first scientists to apply was a risk. I think a lot of funding agencies are David G. Kirsch, MD, PhD. He proposed a new satisfied with incremental science that is operating room imaging device that would guaranteed to succeed. We couldn’t prove that allow surgeons to scan for residual cancer cells any of this would work, but the Foundation said, after removing a patient’s tumor. “When we ‘This is a risk worth taking.’” reviewed David’s written proposal, it ranked And it was. Since receiving the award, David just high enough to get him an interview,” and his team have built and successfully tested Ron remembers. “I was one of the people that the imaging device in mice and dogs. This year, thought it probably would not succeed. Then he they received FDA approval to begin a first- presented the work in person and went to the in-human clinical trial, which recently opened top of the list.” at Duke and is recruiting its first patients.
2012 annual report / 06 “I think when we look back at investigators like Muneesh in ten years, whether their original projects have succeeded or not, showing them that they can survive while thinking innovatively is itself a success.”
Kenneth W. Kinzler, PhD
Kenneth W. Kinzler, PhD Professor of Oncology, The Johns Hopkins University Kimmel Cancer Center Member, Damon Runyon-Rachleff Innovation Award Committee Completed the first whole genome sequence analyses of colorectal, breast and glioblastoma cancers
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241794_SS_R1.indd 8 10/27/12 12:52 AM Having No Fear Muneesh Tewari, MD, PhD Damon Runyon-Rachleff Innovator Associate Member, Fred Hutchinson Cancer Research Center Associate Professor in Medicine, University of Washington
“What distinguishes these people realized that they were much more stable than is a vision and a passion for that vision. expected. I was interested in ovarian cancer and Having both lets you persevere through the wondered if cancer-specific miRNAs could be obstacles,” says Kenneth W. Kinzler, PhD. really sensitive markers for detecting disease.” “We’re looking for people who won’t be Despite his early progress, Muneesh was in happy unless they’re pursuing a problem trouble. His lab’s first three years of startup about which they’re passionate.” funding were running out. “The first real Ken knows a thing or two about vision. “We discouragement was getting rejected by the have had many projects in our group that initially National Institutes of Health for funding. I didn’t seemed crazy,” he says. “We were interested know what the fate of my lab would be. Then I in detecting DNA mutations in the blood, for read about Damon Runyon’s Innovation Award. example. Cancer cells, as they grow, release a It’s rare to have the type of funding that allows small amount of DNA into the bloodstream. So you to pursue a risky idea that has a 90% we had this vision of a technique that would chance of failing.” Receiving the award was allow us to detect these rare mutations. It “the turning point in terms of surviving as required a lot of work, but today, 3 of the 4 major a scientist,” he says. “I was utterly elated.” DNA sequencing platforms use our technique.” Muneesh's first pass at using miRNAs for When Ken reviewed the application of early cancer detection did not work the way he Muneesh Tewari, MD, PhD, he immediately saw had planned, yet it still gave him important new a young scientist with a bold vision and similar insights. Recently, he found that a particular tenacity. Muneesh seeks to develop a blood miRNA made by ovarian tumors can be detected test that can spot cancer before it is visible by in the blood of early stage patients; he is now any other means using microRNAs (miRNAs), developing this toward an early detection test. tiny molecules that regulate gene activity and “Was it a home run in three years? No,” he says. appear to be altered in many types of cancers. “What’s been gained is a more sophisticated As Ken says, “You start a project like this and understanding of both the early detection don’t know exactly how you’re going to get to problem and of basic priniciples of miRNAs in early diagnosis, but that’s where the risk is.” the blood. This is starting to pay off now." “I have always had the most success trying “From stimulating miRNA release to working things off the main path, which I think led to with engineers to build something like a home our discovery of miRNAs in the bloodstream,” glucometer that detects miRNAs in the blood, Muneesh says. “The prevailing wisdom at the the Innovation Award has pushed me to think time was that there was no way for miRNAs about innovative ways to overcome barriers to survive on their own in the blood. But we that no one has crossed yet.”
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241794_SS_R1.indd 9 10/27/12 12:52 AM “Nathanael’s project is different in part because he starts with a very solid background as a chemist. He has a unique understanding of the structure of proteins. It’s an approach with great technical obstacles, and overcoming these will require innovative thinking.” Napoleone Ferrara, MD
Napoleone Ferrara, MD Genentech Fellow: Tumor Biology and Angiogenesis Member, Damon Runyon- Rachleff Innovation Award Committee Discovered VEGF, a regulator of tumor blood vessel growth, leading to the development of the drugs Avastin and Lucentis
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241794_SS_R1.indd 10 10/27/12 12:53 AM Seeing the forest for the trees Nathanael S. Gray, PhD Damon Runyon-Rachleff Innovator Professor, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Assistant Professor, Cancer Biology, Dana-Farber Cancer Institute
There is no single switch that turns that renders the drugs ineffective. Nathanael is cancers on and off. As Napoleone Ferrara, MD, taking a big-picture approach by looking puts it, “Cancer is diabolically clever.” When downstream to predict how cancers might we think we have beaten it, he says, “cancer adapt. “We figure out a target like EGFR, seems to find a clever way to escape.” decipher how it mutates, then try to find one or Napoleone knows this too well. He is two other targets that, when combined, make recognized around the world as the innovative it much harder for the tumor to find a way mind behind Avastin, a cancer treatment around treatment. The hope is that we’ll be that works by blocking a protein called VEGF, able to keep it inactive for 5, 10 or 15 years.” which enables tumors to grow blood vessels “We found a compound and an approach that feed their rapid growth. It has saved where we could specifically target the countless lives and is approved by the FDA to mutant EGFR that evolved in response to the treat colon and certain types of lung, renal and first generation of treatment. Now, there brain cancers. However, many patients develop are companies that have taken this second- resistance to Avastin. generation compound and are testing it A new generation of scientists like Damon in clinical trials. Patients that respond for Runyon-Rachleff Innovator Nathanael S. 18 months are now being put on a second Gray, PhD, is finding ways to outsmart cancer compound to try to create a longer response. resistance. Like Napoleone, Nathanael is It has a precedent in HIV, where nobody gets a focused on developing chemical compounds single drug but instead a cocktail of four.” that target cancer. “For me, innovation Like a true innovator, Nathanael’s vision does really lies in the ability to take a step not stop at EGFR. “What gets me excited is back and ask what would move the field when we make something that actually works in forward,” he says. “Sometimes it helps to a biological context. We’re anticipating resistance look from the outside so you don’t miss the to our compound and making third-generation forest for the trees.” That is exactly how he versions. EGFR is only found in about 10-15% has approached the EGFR problem. of people with lung cancer. There’s another EGFR is a protein on the surface of our cells target, KRAS, that is in 35-40% of patients, but that, when overactivated, can cause lung and the chemistry is a lot more challenging. It has other cancers. Treatments that target EGFR been considered undruggable because can slow the growth and spread of tumors for conventional approaches haven’t worked, but we up to 18 months. Unfortunately, cancer cells have some tricks that might. If we’re successful, adapt and develop a mutated version of EGFR many more patients stand to benefit.”
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241794_SS_R1.indd 11 10/27/12 12:53 AM THE YEAR IN REVIEW
Damon Runyon is currently Elaine V. Fuchs, PhD, former Fellow and funding 131 young scientists current Damon Runyon Board Member, at 54 leading institutions in 19 received the prestigious March of Dimes states. Nearly $12 million was Prize, given to leaders in the field of MADE in new awards in FY 2012. developmental biology. Former Clinical Investigator Scott A. OUR scientists made countless Armstrong, MD, PhD, was awarded the discoveries. For Example, they: Paul Marks Prize for Cancer Research for his exceptional research in the fields of cancer demonstrated in clinical trials that new stem cells and genomics. immunotherapies reduce tumors in patients with types of melanoma, lung, renal and We held our firstAccelerating Cancer other cancers. Cures Research Symposium at Pfizer Inc. led a breakthrough trial of the drug headquarters in New York City. The event brought vismodegib, which stopped tumor growth together dozens of scientists from industry and in a form of basal-cell carcinoma. academia to discuss the latest clinical research completed the first comprehensive genome and opportunities for collaboration. sequencing of colorectal, melanoma and prostate cancers, revealing the most detailed In partnership with the Sohn Conference look ever at the sources and vulnerabilities of Foundation, we launched the Damon these diseases. Runyon-Sohn Pediatric Cancer Fellowship, designed to address the Their innovative research shortage of scientists focusing on finding was widely recognized: new cures for childhood cancers.
Former Fellows Rachel D. Green, PhD, Gregory J. Hannon, PhD, and Eckard A.F. Wimmer, PhD, were elected to the National Academy of Sciences (the science “Hall of Fame”), bringing Damon Runyon’s total to 62.
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241798_SS_R3.indd 13 11/5/12 7:30 PM Thank you to our Donors The innovative research that Damon Runyon scientists do every day would not be possible without your support. We are very grateful for your generosity and commitment to the nation’s best and brightest young scientists, who will make the next breakthroughs against cancer. Thanks to you, Damon Runyon raised approximately $10.8 million in Fiscal Year 2012.
ANNUAL BREAKFAST HONORING MILES S. NADAL
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The Sohn Conference Foundation granted Damon Runyon $1.5 million to launch our newest award, the Damon Runyon-Sohn Pediatric Cancer Fellowship. See page 23 to learn about our first three Pediatric Fellows.
Our 2012 Annual Breakfast honored Miles S. Nadal, Chairman and CEO of MDC Partners, one of the world’s largest marketing and communications networks. The event raised $1.3 million for cancer research.
Our annual Damon Runyon 5K at Yankee Stadium raised more than $730,000 in August 2011, drawing a capacity crowd of 4,000 participants. A special thanks to former Yankees player Roy White, Red Sox Chairman Thomas Werner, NBC4 anchor Michael Gargiulo and our sponsors: the MetLife Foundation, Unilever, White Rose, C9 by Champion, NYSID, 24 Hour Fitness, NBC4 New York, the New York Daily News, SiriusXM Radio, Poland Spring and Utz.
Damon Runyon Broadway Tickets continues to offer house seats to the best shows in town like The Book of Mormon and Glengarry Glen Ross. We are especially grateful to the Shubert Organization, Nederlander Productions, Jujamcyn Theaters and Disney Theatrical Productions for making this program possible. Learn more at www.damonrunyon.org/broadway.
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CHAIR Steven J. Burakoff, MD Mr. Alan M. Leventhal Director Chair and Chief Executive Officer The Tisch Cancer Institute Beacon Capital Partners, LLC Professor, Oncological Sciences Boston, Massachusetts Professor of Medicine, Hematology and Medical Oncology Mount Sinai School of Medicine VICE CHAIR VICE CHAIR New York, New York Development and Scientific Programs Communications David M. Livingston, MD Alan M. Leventhal William L. Carroll, MD Mr. David M. Beirne Deputy Director Julie and Edward J. Minskoff Professor Chair Coral Gables, Florida and Aspen, Colorado Dana-Farber/Harvard Cancer Center of Pediatrics, Professor of Pathology Emil Frei III Professor of Genetics and Director, NYU Cancer Institute VICE CHAIR Medicine NYU Langone Medical Center Finance and Treasurer Harvard Medical School New York, New York Mr. Leon G. Cooperman Boston, Massachusetts Chair and Chief Executive Officer Ms. Deborah J. Coleman Omega Advisors, Inc. VICE CHAIR Legal Counsel New York, New York Audit and Corporate Convexity Capital Management LP Governance and Secretary Boston, Massachusetts VICE CHAIR Sanford W. Morhouse, Esq. Board Development Of Counsel Mr. Gary E. Erlbaum Mr. Michael L. Gordon Schulte Roth & Zabel LLP President Chief Operating Officer New York, New York Greentree Properties Angelo, Gordon & Co. Ardmore, Pennsylvania New York, New York Thomas J. Fahey, Jr., MD Senior Vice President Emeritus Memorial Sloan-Kettering Cancer Center New York, New York
Mr. Buck French San Francisco, California
Mr. Dale F. Frey Retired Chair of the Board and President General Electric Investment Corporation Weston, Connecticut
Elaine V. Fuchs, PhD Rebecca C. Lancefield Professor Laboratory Head, Mammalian Cell Biology and Development The Rockefeller University New York, New York
Richard B. Gaynor, MD Vice President Product Development/Medical Affairs Eli Lilly and Company Indianapolis, Indiana
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241794_SS_R1.indd 16 10/27/12 12:55 AM Steven J. Burakoff, MD Todd R. Golub, MD Mr. John H. Myers Director Chief Scientific Officer and Director of Senior Advisor The Tisch Cancer Institute the Cancer Program of the Angelo, Gordon & Co. Professor, Oncological Sciences Broad Institute of Harvard and MIT New York, New York Professor of Medicine, Hematology Charles A. Dana Investigator in Human and Medical Oncology Cancer Genetics Richard J. O’Reilly, MD Mount Sinai School of Medicine Dana-Farber Cancer Institute Chair, Department of Pediatrics VICE CHAIR New York, New York Professor of Pediatrics Chief, Pediatric Bone Marrow Scientific Programs Harvard Medical School Transplantation Service David M. Livingston, MD William L. Carroll, MD Cambridge, Massachusetts Claire L. Tow Chair in Pediatric Deputy Director Julie and Edward J. Minskoff Professor Oncology Research Dana-Farber/Harvard Cancer Center of Pediatrics, Professor of Pathology Mr. Scott Greenstein Memorial Sloan-Kettering Cancer Center Emil Frei III Professor of Genetics and Director, NYU Cancer Institute President, Entertainment & Sports New York, New York Medicine NYU Langone Medical Center SiriusXM Satellite Radio, Inc. Harvard Medical School New York, New York New York, New York Mr. Andrew S. Rachleff Boston, Massachusetts President and Chief Executive Officer Ms. Deborah J. Coleman Mr. Steve Hayden Wealthfront VICE CHAIR Legal Counsel Vice Chair, Retired Faculty Audit and Corporate Convexity Capital Management LP Ogilvy & Mather Worldwide Stanford Graduate School of Business Governance and Secretary Boston, Massachusetts New York, New York Palo Alto, California Sanford W. Morhouse, Esq. Of Counsel Mr. Gary E. Erlbaum Mr. Bill Helman Mr. Scott Ryles Schulte Roth & Zabel LLP President Chief Executive Officer and Chief Executive Officer and President New York, New York Greentree Properties Managing Partner Amtrust North America Ardmore, Pennsylvania Greylock Partners San Francisco, California Cambridge, Massachusetts Thomas J. Fahey, Jr., MD Ms. Karen D. Seitz Senior Vice President Emeritus Mr. Jay W. Ireland Founder and Managing Director Memorial Sloan-Kettering President and Chief Executive Officer Fusion Partners Cancer Center GE Africa New York, New York New York, New York Nairobi, Kenya William R. Sellers, MD Mr. Buck French Mr. Steven A. Kandarian Vice President and Global Head, Oncology San Francisco, California Chairman, President and Chief Novartis Institutes for Executive Officer Biomedical Research Mr. Dale F. Frey MetLife, Inc. Cambridge, Massachusetts Retired Chair of the Board and President New York, New York General Electric Investment Corporation Samuel C. Silverstein, MD Weston, Connecticut Mr. Noah Knauf John C. Dalton Professor Principal Department of Physiology and Elaine V. Fuchs, PhD Warburg Pincus Cellular Biophysics Rebecca C. Lancefield Professor San Francisco, California Columbia University Laboratory Head, Mammalian Cell New York, New York Biology and Development Ronald Levy, MD The Rockefeller University Professor, Division of Oncology New York, New York Stanford University School of Medicine Ms. Lorraine W. Egan Stanford, California President and Chief Executive Officer Richard B. Gaynor, MD Damon Runyon Cancer Research Vice President Mr. David G. Marshall Foundation Product Development/Medical Affairs Chair and Chief Executive Officer New York, New York Eli Lilly and Company Amerimar Realty Company [email protected] Indianapolis, Indiana Philadelphia, Pennsylvania
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Chair Lynn Cooley, PhD C.N.H. Professor of Genetics and Professor of Cell Biology and Molecular, Cellular and Developmental Biology Department of Genetics Yale University School of Medicine Damon Runyon New Haven, Connecticut
Award programs Vice-Chair Frederick R. Cross, PhD Professor Damon Runyon Damon Runyon-Rachleff Laboratory of Cell Cycle Genetics Fellowship Award Innovation Award The Rockefeller University Supports the training of the brightest postdoctoral Supports the next generation of exceptionally New York, New York scientists as they embark upon their research creative thinkers with high-risk, high-reward ideas David P. Bartel, PhD careers. This funding enables them to be mentored that have the potential to significantly impact our Howard Hughes Medical Institute by established investigators in leading research understanding of and approaches to the prevention, Investigator laboratories across the country. diagnosis or treatment of cancer. Professor of Biology Massachusetts Institute of Technology Three-Year Award Three-Year Award: $450,000 Member Basic Scientists: $156,000 Whitehead Institute for Biomedical This program is possible through a founding Research Physician-Scientists: $186,000 grant from Debra and Andrew S. Rachleff and the Cambridge, Massachusetts support of the Island Outreach Foundation and Nadia’s Gift Foundation. Andrew G. Dillin, PhD Damon Runyon-Sohn Pediatric Howard Hughes Medical Institute Cancer Fellowship Award Investigator Supports dedicated basic scientists and clinicians Damon Runyon Clinical Associate Professor of Molecular and who conduct research with the potential to Investigator Award Cell Biology Salk Institute for Biological Studies significantly impact the prevention, diagnosis or Supports early career physician-scientists La Jolla, California treatment of one or more pediatric cancers. conducting patient-oriented research. The goal of this innovative program is to increase the number Robert N. Eisenman, PhD Three-Year Award of physicians capable of moving seamlessly Member, Basic Sciences Division Basic Scientists: $156,000 Fred Hutchinson Cancer Research Center between the laboratory and the patient’s bedside in Physician-Scientists: $186,000 Seattle, Washington search of breakthrough treatments. This program is supported by the Sohn Sankar Ghosh, PhD Conference Foundation, committed to curing Three-Year Award: $450,000 plus up to Silverstein and Hutt Family Professor of pediatric cancers, in partnership with the Damon $100,000 for medical school loan repayment. Microbiology and Immunology Runyon Cancer Research Foundation. This program is supported by founding sponsor Chair, Department of Microbiology and Immunology Eli Lilly and Company in addition to Ariad, Celgene, Columbia University Dale F. Frey Award for Genentech, Merck, Millennium: The Takeda New York, New York Oncology Company, Pfizer and PhRMA, all of which Breakthrough Scientists are members of Accelerating Cancer Cures. R. Kiplin Guy, PhD Supports a select few Damon Runyon Fellows who Chair and Member have greatly exceeded the Foundation’s highest Department of Chemical Biology and expectations. This additional investment in these Damon Runyon Clinical Investigator Therapeutics Continuation Grant St. Jude Children’s Research Hospital exceptional individuals will help catapult their Memphis, Tennessee research careers and their impact on cancer. Supports Damon Runyon Clinical Investigators who are approaching the end of their original Kevin M. Haigis, PhD Two-Year Award: $100,000 three-year awards and need extra time and Assistant Professor This program was created to honor Dale F. Frey, funding to complete a promising avenue of Department of Pathology retired Chairman of the Damon Runyon Board of Harvard Medical School research or initiate/continue a clinical trial. Directors, in recognition of his sixteen years of Assistant Professor, Molecular $300,000 Pathology Unit visionary leadership. Two-Year Award: Massachusetts General Hospital This program is possible through the support of the Charlestown, Massachusetts William K. Bowes, Jr. Foundation and Connie and Bob Lurie.
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Chair Thomas S. Hays, PhD Ramon E. Parsons, MD, PhD Lynn Cooley, PhD Professor, Department of Genetics, Cell Avon Foundation Professor of C.N.H. Professor of Genetics and Biology and Development Pathology, Cell Biology and Medicine Professor of Cell Biology and University of Minnesota Institute for Cancer Genetics Molecular, Cellular and Minneapolis, Minnesota Herbert Irving Comprehensive Developmental Biology Cancer Center Department of Genetics Maria Jasin, PhD Columbia University Yale University School of Medicine Lab Head, Developmental Biology New York, New York New Haven, Connecticut Program Sloan-Kettering Institute Alexander Y. Rudensky, PhD Vice-Chair New York, New York Howard Hughes Medical Institute Frederick R. Cross, PhD Investigator Professor Alex L. Kolodkin, PhD Chair, Immunology Program Damon Runyon-Rachleff Laboratory of Cell Cycle Genetics Howard Hughes Medical Institute Memorial Sloan-Kettering Cancer Center Innovation Award The Rockefeller University Investigator New York, New York Supports the next generation of exceptionally New York, New York Professor, The Solomon H. Snyder Department of Neuroscience Amita Sehgal, PhD creative thinkers with high-risk, high-reward ideas David P. Bartel, PhD The Johns Hopkins University School Howard Hughes Medical Institute that have the potential to significantly impact our Howard Hughes Medical Institute of Medicine Investigator understanding of and approaches to the prevention, Investigator Baltimore, Maryland John Herr Muser Professor, Department of Neuroscience diagnosis or treatment of cancer. Professor of Biology Massachusetts Institute of Technology Jun O. Liu, PhD University of Pennsylvania School Three-Year Award: $450,000 Member Professor of Medicine Whitehead Institute for Biomedical Departments of Pharmacology and Philadelphia, Pennsylvania This program is possible through a founding Research Molecular Sciences grant from Debra and Andrew S. Rachleff and the Cambridge, Massachusetts The Johns Hopkins University School Brent R. Stockwell, PhD support of the Island Outreach Foundation and of Medicine Associate Professor Nadia’s Gift Foundation. Andrew G. Dillin, PhD Baltimore, Maryland Department of Biological Sciences and Howard Hughes Medical Institute Department of Chemistry Investigator Liqun Luo, PhD Columbia University Damon Runyon Clinical Associate Professor of Molecular and Howard Hughes Medical Institute New York, New York Investigator Investigator Award Cell Biology Salk Institute for Biological Studies Professor, Department of Biology Wilfred A. van der Donk, PhD Supports early career physician-scientists La Jolla, California Stanford University Howard Hughes Medical Institute conducting patient-oriented research. The goal of Stanford, California Investigator this innovative program is to increase the number Robert N. Eisenman, PhD Richard E. Heckert Endowed Chair Terry Magnuson, PhD of Chemistry of physicians capable of moving seamlessly Member, Basic Sciences Division Fred Hutchinson Cancer Research Center Sarah Graham Kenan Professor University of Illinois, Urbana-Champaign between the laboratory and the patient’s bedside in Seattle, Washington Chair, Department of Genetics Urbana, Illinois search of breakthrough treatments. Vice Dean for Research, School Sankar Ghosh, PhD of Medicine Terry A. Van Dyke, PhD Three-Year Award: $450,000 plus up to Silverstein and Hutt Family Professor of Program Director, Cancer Genetics, Director, Center for Advanced $100,000 for medical school loan repayment. Microbiology and Immunology Lineberger Comprehensive Preclinical Research Cancer Center Sr. Investigator, Mouse Cancer This program is supported by founding sponsor Chair, Department of Microbiology and Immunology University of North Carolina School Genetics Program Eli Lilly and Company in addition to Ariad, Celgene, Columbia University of Medicine Frederick National Laboratory for Genentech, Merck, Millennium: The Takeda New York, New York Chapel Hill, North Carolina Cancer Research Oncology Company, Pfizer and PhRMA, all of which Center for Cancer Research are members of Accelerating Cancer Cures. R. Kiplin Guy, PhD David J. McConkey, PhD Frederick, Maryland Chair and Member Director of Urologic Research Department of Chemical Biology and Professor, Departments of Urology and Damon Runyon Clinical Investigator Therapeutics Cancer Biology The University of Texas M.D. Anderson Continuation Grant St. Jude Children’s Research Hospital Memphis, Tennessee Cancer Center Supports Damon Runyon Clinical Investigators Houston, Texas who are approaching the end of their original Kevin M. Haigis, PhD three-year awards and need extra time and Assistant Professor Michael T. McManus, PhD Department of Pathology Director, Keck Center for Noncoding RNAs funding to complete a promising avenue of Harvard Medical School Director, Sandler Lentiviral RNAi Core research or initiate/continue a clinical trial. Assistant Professor, Molecular Professor, Department of Microbiology Pathology Unit and Immunology Two-Year Award: $300,000 Massachusetts General Hospital Diabetes Center This program is possible through the support of the Charlestown, Massachusetts University of California, San Francisco William K. Bowes, Jr. Foundation and Connie and San Francisco, California Bob Lurie.
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California David K. Breslow, PhD Sabrina L. Spencer, PhD Adam de la Zerda, PhD Connie and Bob Lurie Fellow “Protein expression dynamics and "Imaging cancer glycomes with Lisa R. Racki, PhD* "Dissecting the functions of thresholds in cell cycle commitment” functionalized carbon nanotubes" with Howard Hughes Medical Institute Fellow phosphoinositide lipids in the primary with Tobias Meyer, PhD, Stanford Carolyn R. Bertozzi, PhD, University of "Polyphosphates and stationary phase cilium" with Maxence V. Nachury, PhD, University School of Medicine, Stanford California, Berkeley survival” with Dianne K. Newman, PhD, Stanford University School of Medicine, California Institute of Technology, Stanford Alexander Ward, PhD Christopher J. Hale, PhD Pasadena Howard Hughes Medical Institute Fellow Howard Hughes Medical Institute Fellow Steven D. Cappell, PhD* "Investigations of cancer signaling “Understanding how a histone James P. Scott-Browne, PhD "Molecular dynamics of the G1/S pathways in Drosophila olfactory system methyltransferase links DNA replication, Fraternal Order of Eagles Fellow transition” with Tobias Meyer, PhD, development" with Liqun Luo, PhD, repair and transcription” with Steven E. "Function and genomic stability of Stanford University School of Medicine, Stanford University School of Medicine, Jacobsen, PhD, University of California, 5-hydroxymethylcytosine" with Anjana Stanford Stanford Los Angeles Rao, PhD, La Jolla Institute for Allergy and Immunology, La Jolla Sarah E. Ewald, PhD Qiong Yang, PhD Yanling Wang, PhD* Dennis and Marsha Dammerman Fellow Howard Hughes Medical Institute Fellow Robert Black Fellow Gabriel C. Lander, PhD "Innate immune detection of "Nonlinear coupling of positive and "Diversity generating retroelement- Merck Fellow Toxoplasma gondii in the host cell negative feedback loops in Xenopus mediated surface-protein display in “Structural basis of GTP hydrolysis in cytosol" with John C. Boothroyd, PhD, early embryonic cycles" with James E. Bacteroides fragilis and its roles in host- microtubule dynamic instability” with Stanford University School of Medicine, Ferrell, MD, PhD, Stanford University microbe interactions” with Jeffery F. Eva Nogales, PhD, Lawrence Berkeley Stanford School of Medicine, Stanford Miller, PhD, University of California, National Laboratory, Berkeley Los Angeles Mingye Feng, PhD* Gamze Ö. Çamdere, PhD* Lora B. Sweeney, PhD* "Macrophage-mediated "In vitro and in vivo characterization of Gira Bhabha, PhD* Howard Hughes Medical Institute Fellow immunosurveillance in metastasis” cohesin-DNA interaction” with Douglas Merck Fellow "Spinal circuit remodeling during with Irving L. Weissman, MD, Stanford E. Koshland, PhD, University of California, "High-resolution studies of dynein developmental transitions in motor University School of Medicine, Stanford Berkeley structure and mechanism” with Ronald behavioral strategy” with Christopher R. D. Vale, PhD, University of California, Kintner, PhD, and Thomas M. Jessell, Tom A. Hartl, PhD Leon Y. Chan, PhD San Francisco PhD, Salk Institute, La Jolla Robert Black Fellow Howard Hughes Medical Institute Fellow “The role of lipids in Hedgehog signal "Determining the mechanism of stress- Stephanie T. Chen, PhD* Hua Lu, PhD transduction” with Matthew P. Scott, induced ribosomal protein mRNA "Analysis of somatosensory neuron The Jake Wetchler Foundation Fellow PhD, Stanford University School of degradation" with Karsten Weis, PhD, function and lineage through nuclear for Pediatric Innovation Medicine, Stanford University of California, Berkeley reprogramming” with David J. Julius, "Homogeneous antibody-drug PhD, University of California, conjugates containing unnatural amino Wan-Jin Lu, PhD Elie J. Diner, PhD* San Francisco acid for targeted AML therapy" with Merck Fellow "Cytosolic detection of intracellular Peter G. Schultz, PhD, The Scripps "The role of injury-inducible epithelial/ pathogen-derived nucleic acids by the Damian C. Ekiert, PhD* Research Institute, La Jolla stromal feedback signaling pathways in innate immune system” with Russell "Exploring the role of a novel, bladder cancer" with Philip A. Beachy, E. Vance, PhD, University of California, polymorphic protein family in M. Raymond E. Moellering, PhD PhD, Stanford University School of Berkeley tuberculosis pathogenesis” with Jeffery Howard Hughes Medical Institute Fellow Medicine, Stanford S. Cox, PhD, University of California, "Characterization of novel pathogenic Yumi Kim, PhD San Francisco pathways in cancer: do tumor cells use Douglas H. Phanstiel, PhD* Howard Hughes Medical Institute Fellow quorum-sensing molecules to support "Variation of transcription factor binding” "Identification of the signaling cascades Kimberley Evason, MD, PhD† malignancy?" with Benjamin F. Cravatt, with Michael P. Snyder, PhD, Stanford regulating meiotic chromosome Robert Black Fellow PhD, The Scripps Research Institute, University School of Medicine, Stanford dynamics" with Abby F. Dernburg, PhD, “Hepatic stellate cell development and La Jolla University of California, Berkeley role in carcinogenesis” with Didier Y.R. Jason A. Reuter, PhD Stainier, PhD, University of California, Pedro J. Batista, PhD “Integrative analysis of human cancers Maurizio Righini, PhD San Francisco Kenneth G. and Elaine A. Langone Fellow using high throughput sequencing” Merck Fellow "Role of RNA modifications in lncRNA with Michael P. Snyder, PhD, Stanford "Single molecule translation control" Xi Huang, PhD function" with Howard Y. Chang, MD, University School of Medicine, Stanford with Carlos Bustamante, PhD, University "Functional significance of potassium PhD, Stanford University School of of California, Berkeley channel EAG2 in medulloblastoma" with Medicine, Stanford Volker Schweikhard, PhD Lily Y. Jan, PhD, University of California, “A single-molecule study of factors Lara C. Skwarek, PhD San Francisco Christopher J. Bohlen, PhD* TFIIS and TFIIF during transcriptional Robert Black Fellow "Glial activation in neuropathic injury elongation by RNA polymerase II” “In vivo identification of novel regulators Calvin H. Jan, PhD and pain” with Ben A. Barres, MD, PhD, with Steven M. Block, PhD, Stanford of epithelial-mesenchymal transition” Rebecca Ridley Kry Fellow Stanford University School of Medicine, University School of Medicine, Stanford with David Bilder, PhD, University of "Studying translation with subcellular Stanford California, Berkeley resolution" with Jonathan S. Weissman, PhD, University of California, San Francisco
19 / damon runyon cancer research foundation
241794_SS_R1.indd 20 10/27/12 12:55 AM Sabrina L. Spencer, PhD Adam de la Zerda, PhD Ryota Matsuoka, PhD* Melanie Issigonis, PhD* “Protein expression dynamics and "Imaging cancer glycomes with "Neurovascular interplay during the Howard Hughes Medical Institute Fellow thresholds in cell cycle commitment” functionalized carbon nanotubes" with development and regeneration of the "Germ cell specification from somatic with Tobias Meyer, PhD, Stanford Carolyn R. Bertozzi, PhD, University of neuronal and vascular networks” with stem cells in planarians” with Phillip A. University School of Medicine, Stanford California, Berkeley Didier Y.R. Stainier, PhD, University of Newmark, PhD, University of Illinois, California, San Francisco Urbana Alexander Ward, PhD Christopher J. Hale, PhD Howard Hughes Medical Institute Fellow Howard Hughes Medical Institute Fellow Cory Y. McLean, PhD* "Investigations of cancer signaling “Understanding how a histone "Identifying mutations and epimutations Maryland pathways in Drosophila olfactory system methyltransferase links DNA replication, that drive evolution of low-grade Nicholas R. Guydosh, PhD development" with Liqun Luo, PhD, repair and transcription” with Steven E. gliomas” with Joseph F. Costello, PhD, Howard Hughes Medical Institute Fellow Stanford University School of Medicine, Jacobsen, PhD, University of California, University of California, San Francisco “Genome-wide regulation and dynamics Stanford Los Angeles of ribosome elongation” with Rachel Dale Muzzey, PhD D. Green, PhD, The Johns Hopkins Qiong Yang, PhD Yanling Wang, PhD* Howard Hughes Medical Institute Fellow University, Baltimore Howard Hughes Medical Institute Fellow Robert Black Fellow “Resolving general principles of cis "Nonlinear coupling of positive and "Diversity generating retroelement- translational regulation in eukaryotes Robin E. Stanley, PhD negative feedback loops in Xenopus mediated surface-protein display in using high-throughput and mechanistic “Structural and biochemical early embryonic cycles" with James E. Bacteroides fragilis and its roles in host- analyses of allelic expression in Candida characterization of the autophagy Ferrell, MD, PhD, Stanford University microbe interactions” with Jeffery F. albicans” with Jonathan S. Weissman, specific class 3 phosphatidylinositol School of Medicine, Stanford Miller, PhD, University of California, PhD, University of California, 3-phosphate complex” with James Los Angeles San Francisco H. Hurley, PhD, National Institute of Gamze Ö. Çamdere, PhD* Diabetes and Digestive and Kidney "In vitro and in vivo characterization of Gira Bhabha, PhD* Deniz Simsek, PhD Diseases, Bethesda cohesin-DNA interaction” with Douglas Merck Fellow Philip O’Bryan Montgomery, Jr., MD, Fellow E. Koshland, PhD, University of California, "High-resolution studies of dynein "Understanding the physiological Berkeley structure and mechanism” with Ronald relevance of distinct polyubiquitin chains Massachusetts D. Vale, PhD, University of California, in the maintenance of genome integrity" Anne H. Bothmer, PhD* Leon Y. Chan, PhD San Francisco with David P. Toczyski, PhD, University of The Jake Wetchler Foundation Fellow Howard Hughes Medical Institute Fellow California, San Francisco for Pediatric Innovation "Determining the mechanism of stress- Stephanie T. Chen, PhD* "Identification and characterization of induced ribosomal protein mRNA "Analysis of somatosensory neuron Nathan D. Thomsen, PhD novel ribosome-associated proteins and degradation" with Karsten Weis, PhD, function and lineage through nuclear Suzanne and Bob Wright Fellow their role in hematopoietic development University of California, Berkeley reprogramming” with David J. Julius, "Molecular and cellular mechanism of and disease” with Pier Paolo Pandolfi, PhD, University of California, caspase activation by small molecule MD, PhD, Beth Israel Deaconess Medical Elie J. Diner, PhD* San Francisco proenzyme activators" with James A. Center, Boston "Cytosolic detection of intracellular Wells, PhD, University of California, pathogen-derived nucleic acids by the Damian C. Ekiert, PhD* San Francisco Costas A. Lyssiotis, PhD innate immune system” with Russell "Exploring the role of a novel, Amgen Fellow E. Vance, PhD, University of California, polymorphic protein family in M. Arun P. Wiita, MD, PhD* † “Exploring the metabolic effects of Berkeley tuberculosis pathogenesis” with Jeffery "Novel biomarker discovery for oncogenic KRas in pancreatic ductal S. Cox, PhD, University of California, monitoring chemotherapeutic efficacy” adenocarcinoma” with Lewis C. Cantley, Yumi Kim, PhD San Francisco with James A. Wells, PhD, University of PhD, Beth Israel Deaconess Medical Howard Hughes Medical Institute Fellow California, San Francisco Center, Boston "Identification of the signaling cascades Kimberley Evason, MD, PhD† regulating meiotic chromosome Robert Black Fellow Hyun Youk, PhD Jihye Yun, PhD dynamics" with Abby F. Dernburg, PhD, “Hepatic stellate cell development and Howard Hughes Medical Institute Fellow "Discovering novel metabolic pathways University of California, Berkeley role in carcinogenesis” with Didier Y.R. "Synthetic development: Elucidating and enzymes altered by oncogenes" Stainier, PhD, University of California, principles for genetically encoding with Lewis C. Cantley, PhD, Beth Israel Maurizio Righini, PhD San Francisco simple multicellular architectures using Deaconess Medical Center, Boston Merck Fellow Saccharomyces cerevisiae as a model "Single molecule translation control" Xi Huang, PhD system" with Wendell A. Lim, PhD, with Carlos Bustamante, PhD, University "Functional significance of potassium University of California, San Francisco of California, Berkeley channel EAG2 in medulloblastoma" with Lily Y. Jan, PhD, University of California, Lara C. Skwarek, PhD San Francisco Illinois Robert Black Fellow Yoko Shibata, PhD “In vivo identification of novel regulators Calvin H. Jan, PhD Howard Hughes Medical Institute Fellow of epithelial-mesenchymal transition” Rebecca Ridley Kry Fellow "Identifying protein quality control with David Bilder, PhD, University of "Studying translation with subcellular mechanisms in the nucleus" with California, Berkeley resolution" with Jonathan S. Weissman, Richard I. Morimoto, PhD, Northwestern PhD, University of California, University, Evanston San Francisco
2012 annual report / 20
241794_SS_R1.indd 21 10/27/12 12:55 AM damon runyon Fellowship Awards
(Continued) Renee Otten, PhD* Laura Pontano Vaites, PhD* Christopher J. Michael J. Smanski, PhD* Howard Hughes Medical Institute Fellow "Investigating the role of the CRL3- Shoemaker, PhD* Howard Hughes Medical Institute Fellow "Mechanism of kinases at atomic KBTBD6/7 E3 ubiquitin ligase in "Elucidating the molecular mechanics of "Refactoring the genetics of magnetic resolution” with Dorothee Kern, PhD, autophagosome maturation” with J. autophagy using a cell-free system” with nanoparticle synthesis” with Christopher Brandeis University, Waltham Wade Harper, PhD, Harvard Medical Vlad Denic, PhD, and Andrew W. Murray, A. Voigt, PhD, Massachusetts Institute of School, Boston PhD, Harvard University, Cambridge Technology, Cambridge Angela N. Brooks, PhD* Merck Fellow Joshua J. Sims, PhD Cole Trapnell, PhD Meelad M. Dawlaty, PhD "Characterizing somatic mutations that "Regulation of mitochondrial apoptosis" "Globally characterizing lncRNA “Role of 5hmC and Tet proteins in affect mRNA splicing in cancer” with with Peter K. Sorger, PhD, Harvard oncogenes with next-generation cancer and development” with Rudolf Matthew L. Meyerson, MD, PhD, Dana- Medical School, Boston transcriptomics" with John L. Rinn, PhD, Jaenisch, MD, Whitehead Institute for Farber Cancer Institute, Boston Harvard University, Cambridge Biomedical Research, Cambridge Scott J. Valastyan, PhD Harrison W. Gabel, PhD Harry Kriegel Fellow Ian Y. Wong, PhD Michael E. Pacold, MD, PhD*† “Dissecting the mechanism and "A novel system for the unbiased Merck Fellow Sally Gordon Fellow function of Arc regulation by the discovery of genes that regulate breast “Suppressing cancer cell invasion and "Targeting dehydrogenases in cancer Angelman Syndrome-associated cancer metastasis" with Joan S. Brugge, plasticity in 3D microenvironments” metabolism” with David M. Sabatini, ubiquitin ligase Ube3a” with Michael PhD, Harvard Medical School, Boston with Mehmet Toner, PhD, and Daniel MD, PhD, and Nathanael S. Gray, PhD, E. Greenberg, PhD, Harvard Medical Irimia, MD, PhD, Massachusetts General Whitehead Institute for Biomedical School, Boston Dong Yan, PhD Hospital, Boston Research, Cambridge Howard Hughes Medical Institute Fellow Li He, PhD* “Building a kinase and phosphatase Sidi Chen, PhD* "Molecular characterization of cell network using phosphorylation “Investigation of Dicer as a novel Missouri competition and compensatory cell signatures” with Norbert Perrimon, PhD, therapeutic route towards the inhibition Elizabeth M. Duncan, PhD proliferation in Drosophila” with Norbert Harvard Medical School, Boston of tumorigenesis and neoplastic growth” Howard Hughes Medical Institute Fellow Perrimon, PhD, Harvard Medical School, with Philip A. Sharp, PhD, Massachusetts “Epigenetic regulation of cellular Boston Alexandra Zidovska, PhD Institute of Technology, Cambridge memory during planarian regeneration” “Collective chromatin dynamics: with Alejandro Sánchez Alvarado, PhD, Kristin A. Krukenberg, PhD exploring chromatin positional Daniel A. Heller, PhD Stowers Institute for Medical Research, Fayez Sarofim Fellow fluctuations in interphase” with Timothy “Molecularly imprinted polymeric Kansas City “Understanding the cell biological J. Mitchison, PhD, Harvard Medical antibodies for tumor-targeted siRNA function of poly(ADP-ribose) and School, Boston delivery” with Robert S. Langer, ScD, its role in cancer” with Timothy J. Massachusetts Institute of Technology, New Jersey Mitchison, PhD, Harvard Medical Alistair N. Boettiger, PhD* Cambridge Björn F.C. Kafsack, PhD School, Boston "Using super resolution imaging to probe Howard Hughes Medical Institute Fellow molecular mechanisms of Polycomb Nikhil S. Joshi, PhD “Density-dependent autocrine Ying Lu, PhD silencing” with Xiaowei Zhuang, PhD, “Understanding the development and control of gametocytogenesis in the Lallage Feazel Wall Fellow Harvard University, Cambridge function of regulatory T cells in an virulent malaria parasite Plasmodium "Single-molecular study of autochthonous mouse model of human falciparum” with Manuel Llinás, PhD, ubiquitination/deubiquitination kinetics Niels Bradshaw, PhD non-small cell lung cancer” with Tyler Princeton University, Princeton in cell extracts" with Marc W. Kirschner, “Regulation of the SpoIIE phosphatase Jacks, PhD, Massachusetts Institute of PhD, Harvard Medical School, Boston and activation of a cell-specific Technology, Cambridge Stephanie C. Weber, PhD* transcription factor” with Richard Howard Hughes Medical Institute Fellow John R. Lydeard, PhD M. Losick, PhD, Harvard University, Karl A. Merrick, PhD* "Mechanisms controlling cell and body “Defining CRL4 substrates and Cambridge "Elucidating how inflammation size in the nematode Caenorhabditis regulators through a systematic affects tumorigenesis and response elegans” with Clifford P. Brangwynne, proteomic and functional analysis of David G. Hendrickson, PhD to chemotherapy in colon cancer” PhD, and Howard A. Stone, PhD, DCAFs” with Jeffrey Wade Harper, PhD, Robert Black Fellow with Michael B. Yaffe, MD, PhD, Princeton University, Princeton Harvard Medical School, Boston “A guiding role for lincRNAs in the Massachusetts Institute of Technology, establishment of cancer-like epigenetic Cambridge John J. Karijolich, PhD* Rebecca S. Mathew, PhD landscapes” with John L. Rinn, PhD, "Mechanistic and physiological analysis Howard Hughes Medical Institute Fellow Harvard University, Cambridge Daniel Schmidt, PhD of transcription-dependent gene loops” “Revealing epigenetic changes that Norman B. Leventhal Fellow with Michael Hampsey, PhD, UMDNJ- underlie cellular memory” with Danesh Sumeet Sarin, PhD "Molecular-targeted reagents to probe Robert Wood Johnson Medical School, Moazed, PhD, Harvard Medical School, Marion Abbe Fellow the role of ion channels in glioblastoma New Brunswick Boston "A molecular mechanism of spatial oncogenesis, proliferation, and pattern formation in the vertebrate migration" with Edward S. Boyden, PhD, retina” with Joshua R. Sanes, PhD, Massachusetts Institute of Technology, Harvard University, Cambridge Cambridge
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241794_SS_R1.indd 22 10/27/12 12:55 AM Christopher J. Michael J. Smanski, PhD* New York Pennsylvania Shoemaker, PhD* Howard Hughes Medical Institute Fellow * "Elucidating the molecular mechanics of "Refactoring the genetics of magnetic Leah R. Sabin, PhD Robert K. McGinty, MD, PhD* "The role of long noncoding RNAs in "Structural studies of the MLL1 core autophagy using a cell-free system” with nanoparticle synthesis” with Christopher normal hematopoiesis and malignant methyltransferase complex” with Song Vlad Denic, PhD, and Andrew W. Murray, A. Voigt, PhD, Massachusetts Institute of transformation” with Gregory J. Hannon, Tan, PhD, Pennsylvania State University, PhD, Harvard University, Cambridge Technology, Cambridge PhD, Cold Spring Harbor Laboratory, University Park Cold Spring Harbor Cole Trapnell, PhD Meelad M. Dawlaty, PhD "Globally characterizing lncRNA “Role of 5hmC and Tet proteins in Katarina Moravcevic, PhD* Howard Hughes Medical Institute Fellow oncogenes with next-generation cancer and development” with Rudolf Duncan J. Smith, PhD Howard Hughes Medical Institute Fellow "Investigating the genetic and transcriptomics" with John L. Rinn, PhD, Jaenisch, MD, Whitehead Institute for “Lagging strand synthesis and neurochemical basis of sleep Harvard University, Cambridge Biomedical Research, Cambridge chromatin replication” with Iestyn homeostasis” with Amita Sehgal, PhD, Whitehouse, PhD, Memorial Sloan- University of Pennsylvania School of Ian Y. Wong, PhD Michael E. Pacold, MD, PhD*† Kettering Cancer Center, New York Medicine, Philadelphia Merck Fellow Sally Gordon Fellow “Suppressing cancer cell invasion and "Targeting dehydrogenases in cancer plasticity in 3D microenvironments” metabolism” with David M. Sabatini, Jason A. Hall, PhD* Dale F. and Betty Ann Frey Fellow Tennessee with Mehmet Toner, PhD, and Daniel MD, PhD, and Nathanael S. Gray, PhD, "Regulation of the ligand for retinoic Irimia, MD, PhD, Massachusetts General Whitehead Institute for Biomedical Mary J. Carroll, PhD* acid receptor related orphan receptor "Validation of Vav1 as a druggable Hospital, Boston Research, Cambridge gamma t” with Dan R. Littman, MD, cancer target using small molecules” PhD, New York University School of Sidi Chen, PhD* with Stephen W. Fesik, PhD, Vanderbilt “Investigation of Dicer as a novel Missouri Medicine, New York University Medical Center, Nashville therapeutic route towards the inhibition Elizabeth M. Duncan, PhD Maria Genander, PhD of tumorigenesis and neoplastic growth” Howard Hughes Medical Institute Fellow Dale F. and Betty Ann Frey Fellow Texas with Philip A. Sharp, PhD, Massachusetts “Epigenetic regulation of cellular "Deciphering the mechanisms Institute of Technology, Cambridge memory during planarian regeneration” Sujun Hua, PhD governing BMP regulated stem cell “Genomic analysis of core with Alejandro Sánchez Alvarado, PhD, maintenance in hair follicles" with transcriptional regulatory networks Daniel A. Heller, PhD Stowers Institute for Medical Research, Elaine V. Fuchs, PhD, The Rockefeller in normal and malignant neural stem “Molecularly imprinted polymeric Kansas City antibodies for tumor-targeted siRNA University, New York cells” with Ronald A. DePinho, MD, M.D. delivery” with Robert S. Langer, ScD, Anderson Cancer Center, Houston Massachusetts Institute of Technology, New Jersey Ralph E. Kleiner, PhD* "Investigating the importance of post- Rui Yue, PhD* Cambridge Björn F.C. Kafsack, PhD translational microtubule modification "Functional analysis of leptin receptor Howard Hughes Medical Institute Fellow using recombinant acetylated tubulin” signaling in hematopoietic stem cells Nikhil S. Joshi, PhD “Density-dependent autocrine with Tarun M. Kapoor, PhD, The and perivascular niche” with Sean J. “Understanding the development and control of gametocytogenesis in the Rockefeller University, New York Morrison, PhD, University of Texas function of regulatory T cells in an virulent malaria parasite Plasmodium Southwestern Medical Center, Dallas autochthonous mouse model of human falciparum” with Manuel Llinás, PhD, non-small cell lung cancer” with Tyler Shijing Luo, PhD* Princeton University, Princeton Miles S. Nadal Fellow Jacks, PhD, Massachusetts Institute of "Identifying genetic regulators and Washington Technology, Cambridge Stephanie C. Weber, PhD* mechanisms of stem cell migration in Howard Hughes Medical Institute Fellow Peter J. Skene, PhD* wound repair” with Elaine V. Fuchs, PhD, "Transcriptional memory in iPS cells: Karl A. Merrick, PhD* "Mechanisms controlling cell and body The Rockefeller University, New York suppression of H3.3 deposition to "Elucidating how inflammation size in the nematode Caenorhabditis increase therapeutic potential” with affects tumorigenesis and response elegans” with Clifford P. Brangwynne, to chemotherapy in colon cancer” Maximilian W. Popp, PhD* Mark T. Groudine, MD, PhD, and Steven PhD, and Howard A. Stone, PhD, Howard Hughes Medical Institute Fellow with Michael B. Yaffe, MD, PhD, Henikoff, PhD, Fred Hutchinson Cancer Princeton University, Princeton "A haploid genetic approach towards Massachusetts Institute of Technology, Research Center, Seattle defining RNA decay mechanisms in Cambridge John J. Karijolich, PhD* mammalian cells” with Lynne E. Maquat, * Initial Award "Mechanistic and physiological analysis PhD, University of Rochester School of Daniel Schmidt, PhD † Physician-Scientist of transcription-dependent gene loops” Medicine and Dentistry, Rochester Norman B. Leventhal Fellow with Michael Hampsey, PhD, UMDNJ- "Molecular-targeted reagents to probe Robert Wood Johnson Medical School, the role of ion channels in glioblastoma New Brunswick North Carolina oncogenesis, proliferation, and migration" with Edward S. Boyden, PhD, Erin A. Osborne, PhD Massachusetts Institute of Technology, Howard Hughes Medical Institute Fellow Cambridge "When paths diverge: patterns and mechanisms of asymmetric cell division" with Jason D. Lieb, PhD, University of North Carolina, Chapel Hill
2012 annual report / 22
241794_SS_R1.indd 23 10/27/12 12:55 AM Dale F. Frey Damon Runyon-Rachleff Awards for Breakthrough Scientists Innovation Award COMMittee
Sean C. Bendall, PhD * Ken Cadwell, PhD * Jason M. Crawford, PhD * Chair “Improved single-cell phospho-protein “Characterization of mice deficient in “Systematic approaches to discovering Ronald Levy, MD signaling analysis of oncogenic autophagy protein Atg16L1” at New bioactive bacterial metabolites” at Yale Professor, Division of Oncology progression in leukemia” at Stanford York University School of Medicine, University, New Haven, Connecticut Stanford University School of Medicine University, California New York, New York Stanford, California * Initial Award Robert K. Bradley, PhD * L. Stirling Churchman, PhD Elizabeth H. Blackburn, PhD “Investigating the splicing co-regulatory “Visualizing global transcription in vivo Morris Herzstein Professor of Biology network” at Fred Hutchinson Cancer at nucleotide resolution” at Harvard and Physiology Research Center, Seattle, Washington Medical School, Boston, Massachusetts Department of Biochemistry and Biophysics University of California, San Francisco Damon Runyon-Sohn San Francisco, California Pediatric Cancer Fellowship Award Committee David Botstein, PhD Director, Lewis-Sigler Institute for Integrative Genomics Chair Peter D. Cole, MD James M. Olson, MD, PhD Anthony B. Evnin Professor of Genomics William L. Carroll, MD Associate Professor Member Princeton University Julie and Edward J. Minskoff Professor Department of Pediatrics Division of Clinical Research Princeton, New Jersey of Pediatrics, Professor of Pathology Albert Einstein College of Medicine Fred Hutchinson Cancer Research Center Director, NYU Cancer Institute Montefiore Medical Center Seattle, Washington Michael A. Caligiuri, MD Director, Comprehensive Cancer Center NYU Langone Medical Center Bronx, New York CEO, James Cancer Hospital and New York, New York Martine F. Roussel, PhD Frederick R. Cross, PhD Member Solove Research Institute Scott A. Armstrong, MD, PhD Professor Endowed Chair in Molecular Oncogenesis JL Marakas Nationwide Insurance Associate Professor of Pediatrics Laboratory of Cell Cycle Genetics Co-Director, Cancer Center Signal Enterprise Foundation Professor of Harvard Medical School The Rockefeller University Transduction Program Cancer Research Co-Director Cancer Program, Harvard New York, New York Department of Tumor Cell Biology Professor, Departments of Internal Stem Cell Institute and Genetics Medicine and Molecular Virology, Co-Director Leukemia Program, Dana- R. Kiplin Guy, PhD St. Jude Children’s Research Hospital Immunology, and Medical Genetics Farber Harvard Cancer Center Chairman and Member Memphis, Tennessee The Ohio State University Division of Hematology/Oncology Department of Chemical Biology Columbus, Ohio Children's Hospital, Dana Farber and Therapeutics Christopher C. Wylie, PhD Cancer Institute St. Jude Children’s Research Hospital William Schubert Chair and Director Mark M. Davis, PhD Howard Hughes Medical Institute Boston, Massachusetts Memphis, Tennessee Division of Developmental Biology Cincinnati Children’s Hospital Investigator Patrick A. Brown, MD Maria Jasin, PhD Medical Center Director of the Stanford Institute for Associate Professor Lab Head, Developmental Biology Program Cincinnati, Ohio Immunity, Transplantation and Infection Department of Oncology Sloan-Kettering Institute Stanford University School of Medicine The Johns Hopkins University School New York, New York Stanford, California of Medicine Baltimore, Maryland Barton A. Kamen, MD, PhD Napoleone Ferrara, MD American Cancer Society Clinical Genentech Fellow Research Professor Tumor Biology and Angiogenesis Professor, Department of Pediatric Genentech, Inc. Hematology/Oncology South San Francisco, California UMDNJ-Robert Wood Johnson
Medical Center
The Cancer Institute of New Jersey
New Brunswick, New Jersey
Damon Runyon-Sohn Damon Runyon-Rachleff Pediatric Cancer Fellowship Awards Innovation Awards
Lara E. Davis, MD Angela J. Sievert, MD Leo D. Wang, MD, PhD California "Osteosarcoma as a proof-of-concept "Preclinical models for therapeutic "Phosphoproteomic identification of model for personalized cancer therapy" targeting of BRAF altered pediatric therapeutic targets in AML stem cells" Alexei A. Aravin, PhD “Epigenetic regulation of transposable with Charles Keller, MD, Oregon Health astrocytomas" with John M. Maris, MD, with Amy J. Wagers, PhD, Dana-Farber elements in cancer” at the California and Science University, Portland, Oregon Children's Hospital of Philadelphia, Cancer Institute, Boston, Massachusetts Institute of Technology, Pasadena Pennsylvania
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241794_SS_R1.indd 24 10/27/12 12:56 AM Damon Runyon-Rachleff Innovation Award COMMittee
Jason M. Crawford, PhD * Chair Sanjiv Sam Gambhir, MD, PhD Steven M. Larson, MD “Systematic approaches to discovering Ronald Levy, MD Director, Molecular Imaging Program Chief, Nuclear Medicine Service bioactive bacterial metabolites” at Yale Professor, Division of Oncology Head, Nuclear Medicine Division Donna and Benjamin M. Rosen Chair University, New Haven, Connecticut Stanford University School of Medicine Professor of Radiology, Bioengineering in Radiology Stanford, California and Engineering Materials Science Memorial Sloan-Kettering Cancer Center * Initial Award Stanford University School of Medicine New York, New York Elizabeth H. Blackburn, PhD Stanford, California Morris Herzstein Professor of Biology Jacqueline A. Lees, PhD and Physiology Todd R. Golub, MD Associate Director, David H. Koch Institute Department of Biochemistry and Howard Hughes Medical Institute for Integrative Cancer Research Biophysics Investigator Ludwig Scholar University of California, San Francisco Chief Scientific Officer and Director of Professor of Biology San Francisco, California the Cancer Program of the Massachusetts Institute of Technology Broad Institute of Harvard and MIT Cambridge, Massachusetts David Botstein, PhD Charles A. Dana Investigator in Human Director, Lewis-Sigler Institute for Cancer Genetics Dan R. Littman, MD, PhD Integrative Genomics Dana-Farber Cancer Institute Howard Hughes Medical Institute James M. Olson, MD, PhD Anthony B. Evnin Professor of Genomics Professor of Pediatrics Investigator Member Princeton University Harvard Medical School Helen L. and Martin S. Kimmel Division of Clinical Research Princeton, New Jersey Boston, Massachusetts Professor of Molecular Immunology Fred Hutchinson Cancer Research Center Skirball Institute of Biomolecular Medicine Seattle, Washington Michael A. Caligiuri, MD Rachel D. Green, PhD New York University School of Medicine Director, Comprehensive Cancer Center Howard Hughes Medical Institute New York, New York Martine F. Roussel, PhD CEO, James Cancer Hospital and Investigator Member Solove Research Institute Professor, Department of Molecular Stephen R. Quake, DPhil Endowed Chair in Molecular Oncogenesis JL Marakas Nationwide Insurance Biology and Genetics Howard Hughes Medical Institute Co-Director, Cancer Center Signal Enterprise Foundation Professor of The Johns Hopkins University Investigator Transduction Program Cancer Research Baltimore, Maryland Professor of Bioengineering Department of Tumor Cell Biology Professor, Departments of Internal Co-Chair, Department of Bioengineering and Genetics Medicine and Molecular Virology, Linda G. Griffith, PhD Stanford University St. Jude Children’s Research Hospital Immunology, and Medical Genetics Director, Biotechnology Process Stanford, California Memphis, Tennessee The Ohio State University Engineering Center Columbus, Ohio S.E.T.T. Professor of Biological and Kevan M. Shokat, PhD Christopher C. Wylie, PhD Mechanical Engineering Howard Hughes Medical Institute William Schubert Chair and Director Mark M. Davis, PhD Massachusetts Institute of Technology Investigator Division of Developmental Biology Howard Hughes Medical Institute Cambridge, Massachusetts Professor and Chair Cincinnati Children’s Hospital Investigator Department of Cellular and Molecular Medical Center Director of the Stanford Institute for Gregory J. Hannon, PhD Pharmacology Cincinnati, Ohio Immunity, Transplantation and Infection Howard Hughes Medical Institute University of California, San Francisco Stanford University School of Medicine Investigator San Francisco, California Stanford, California Professor Cold Spring Harbor Laboratory Napoleone Ferrara, MD Cold Spring Harbor, New York Genentech Fellow Tumor Biology and Angiogenesis Kenneth W. Kinzler, PhD Genentech, Inc. Director, The Ludwig Center for South San Francisco, California Cancer Genetics and Therapeutics Professor of Oncology The Johns Hopkins University Kimmel Cancer Center Baltimore, Maryland
Damon Runyon-Rachleff Innovation Awards
Leo D. Wang, MD, PhD California Joshua E. Elias, PhD Heather R. Christofk, PhD "Phosphoproteomic identification of “How cancers cope with damage: “Regulation of cancer metabolism” therapeutic targets in AML stem cells" Alexei A. Aravin, PhD a proteomics approach” at Stanford at the University of California, “Epigenetic regulation of transposable with Amy J. Wagers, PhD, Dana-Farber University School of Medicine, Los Angeles elements in cancer” at the California Cancer Institute, Boston, Massachusetts Stanford Institute of Technology, Pasadena
2012 annual report / 24
241794_SS_R1.indd 25 10/27/12 12:56 AM Damon Runyon-Rachleff Damon Runyon Innovation Awards Clinical Investigator Award Committee
(Continued) (Continued)
Matthew R. Pratt, PhD * Eranthie Weerapana, PhD * Pennsylvania Hedvig Hricak, MD, PhD “O-GIcNAc as a ‘sweet’ link between “Targeting reactive cysteine residues Chair, Department of Radiology metabolism and survival in cancer” at for cancer therapy” at Boston College, Gregory L. Beatty, MD, PhD * Carroll and Milton Petrie Chair Nadia’s Gift Foundation Innovator the University of Southern California, Chestnut Hill Memorial Sloan-Kettering Cancer Center “Targeting macrophages for cancer Los Angeles New York, New York therapy” at the University of Feng Zhang, PhD * Pennsylvania, Philadelphia “Development and application of William G. Kaelin, Jr., MD Colorado genome and epigenome engineering Howard Hughes Medical Institute Jay R. Hesselberth, PhD * tools for cancer research” at The Broad Texas Investigator “Peptide identification by massively- Institute of MIT and Harvard, Cambridge Professor of Medicine parallel sequencing” at the University of Benjamin P. Tu, PhD Harvard Medical School “A novel strategy for attacking tumors Colorado, Denver Dana-Farber Cancer Institute based on the identification of a New York Boston, Massachusetts fundamental carbon-source signal driving Raffaella Sordella, PhD cell growth” at the University of Texas Massachusetts Island Outreach Foundation Innovator Drew M. Pardoll, MD, PhD Southwestern Medical Center, Dallas James E. Bradner, MD “Characterization of Erlotinib resistant, Director, Cancer Immunology Program “Targeting epigenetic readers as cancer Mesenchymal and Metastatic (EMM) Sidney Kimmel Comprehensive *Initial Award therapy” at the Dana-Farber Cancer cells present in naïve lung tumors prior Cancer Center Institute, Boston to treatments” at Cold Spring Harbor Abeloff Professor of Oncology Laboratory, Cold Spring Harbor The Johns Hopkins University School Matthew G. of Medicine Vander Heiden, MD, PhD Joshua C. Munger, PhD Baltimore, Maryland “Understanding the metabolic “Elucidating mechanisms of oncogenic requirements of cancer cells” at metabolic manipulation” at the the David H. Koch Institute of University of Rochester, Rochester Massachusetts Institute of Technology,
Cambridge Damon Runyon Clinical Investigator AwardS Damon Runyon Clinical Investigator Award Committee California Holbrook E. Kohrt, MD, PhD * “Augmenting anticancer antibody therapies through selective activation Chair David P. Carbone, MD, PhD Nancy E. Davidson, MD of NK cells” with Ronald Levy, MD, Director, Specialized Program of Director, University of Pittsburgh Richard J. O’Reilly, MD Stanford University, Stanford Chair, Department of Pediatrics Research Excellence in Lung Cancer Cancer Institute Chief, Pediatric Bone Marrow Ingram Professor of Cancer Research UPMC Cancer Center Jean Y. Tang, MD, PhD Transplantation Service Professor of Medicine and Cancer Biology Associate Vice Chancellor for “Mechanisms of acquired resistance to Claire L. Tow Chair in Pediatric Vanderbilt-Ingram Cancer Center Cancer Research Hedgehog pathway inhibitors in basal Oncology Research Vanderbilt University Professor of Medicine cell carcinomas” with Philip A. Beachy, Memorial Sloan-Kettering Cancer Center Nashville, Tennessee Division of Hematology and Oncology PhD, and Ervin H. Epstein, MD, Stanford New York, New York University of Pittsburgh School University, Stanford Dennis A. Carson, MD of Medicine Professor Emeritus Pittsburgh, Pennsylvania Frederick R. Appelbaum, MD Connecticut Director, Clinical Research Division Department of Medicine Member, Fred Hutchinson Cancer Moores Cancer Center Patricia A. Ganz, MD Tobias J.E. Carling, MD, PhD Research Center University of California, San Diego Director, Division of Cancer Prevention Doris Duke-Damon Head, Division of Medical Oncology La Jolla, California and Control Research Runyon Clinical Investigator University of Washington School Jonsson Comprehensive Cancer Center “Molecular genetics of endocrine tumor of Medicine Bruce A. Chabner, MD Professor, Schools of Medicine and disease” with Richard P. Lifton, MD, PhD, Seattle, Washington Clinical Director Public Health and Robert Udelsman, MD, MBA, Yale Massachusetts General Hospital University of California, Los Angeles University School of Medicine, Joseph R. Bertino, MD Cancer Center Los Angeles, California New Haven Chief Scientific Officer Professor of Medicine The Cancer Institute of New Jersey Harvard Medical School Philip D. Greenberg, MD Massachusetts University Professor of Medicine Boston, Massachusetts Director, Immunology Program Ryan B. Corcoran, MD, PhD * and Pharmacology Member, Fred Hutchinson Cancer “Defining novel targeted therapy UMDNJ-Robert Wood Johnson Research Center combination strategies for BRAF V600 Medical School Professor of Medicine and Immunology mutant colorectal cancer” with Jeffrey New Brunswick, New Jersey University of Washington A. Engelman, MD, PhD, and Keith T. Seattle, Washington Flaherty, MD, Massachusetts General Hospital, Boston
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(Continued)
Pennsylvania Hedvig Hricak, MD, PhD David R. Leslie L. Robison, PhD Chair, Department of Radiology Piwnica-Worms, MD, PhD Member, St. Jude Faculty Gregory L. Beatty, MD, PhD * Carroll and Milton Petrie Chair Director, Molecular Imaging Center Chair, Epidemiology and Cancer Control Nadia’s Gift Foundation Innovator Memorial Sloan-Kettering Cancer Center Professor of Developmental Biology Associate Director for Cancer Prevention “Targeting macrophages for cancer New York, New York and Radiology and Control Cancer Center therapy” at the University of Washington University School of Medicine St. Jude Children’s Research Hospital Pennsylvania, Philadelphia William G. Kaelin, Jr., MD St. Louis, Missouri Memphis, Tennessee Howard Hughes Medical Institute Texas Investigator Kornelia Polyak, MD, PhD Louise C. Strong, MD Professor of Medicine Associate Professor of Medicine Sue and Radcliffe Killam Chair Benjamin P. Tu, PhD Harvard Medical School Department of Medical Oncology Professor of Cancer Genetics “A novel strategy for attacking tumors Dana-Farber Cancer Institute Dana-Farber Cancer Institute Chief, Section of Clinical Cancer Genetics based on the identification of a Boston, Massachusetts Harvard Medical School M.D. Anderson Cancer Center fundamental carbon-source signal driving Boston, Massachusetts The University of Texas cell growth” at the University of Texas Drew M. Pardoll, MD, PhD Houston, Texas Southwestern Medical Center, Dallas Director, Cancer Immunology Program Michael D. Prados, MD, FACP Sidney Kimmel Comprehensive Charles B. Wilson, MD, Endowed Chair David A. Williams, MD *Initial Award Cancer Center in Neurological Surgery Chief, Division of Hematology/Oncology Abeloff Professor of Oncology Director of Translational Research in Director, Translational Research for The Johns Hopkins University School Neuro-Oncology Children’s Hospital Boston of Medicine Leader, Neurological Oncology Program Dana-Farber Cancer Institute Baltimore, Maryland UCSF Comprehensive Cancer Center Leland Fikes Chair of Pediatrics University of California, San Francisco Harvard Medical School San Francisco, California Boston, Massachusetts
Damon Runyon Clinical Investigator AwardS
California Michigan North Carolina Holbrook E. Kohrt, MD, PhD * N. Lynn Henry, MD, PhD Carey K. Anders, MD * “Augmenting anticancer antibody Lilly Clinical Investigator “mTOR inhibition in the treatment of therapies through selective activation “Pain processing pathway analysis HER2-positive breast cancer brain Nancy E. Davidson, MD of NK cells” with Ronald Levy, MD, in aromatase inhibitor-associated metastases” with Lisa A. Carey, MD, Director, University of Pittsburgh Stanford University, Stanford musculoskeletal syndrome” with Daniel and Charles M. Perou, PhD, University of Cancer Institute F. Hayes, MD, University of Michigan, North Carolina, Chapel Hill UPMC Cancer Center Jean Y. Tang, MD, PhD Ann Arbor Associate Vice Chancellor for “Mechanisms of acquired resistance to Oren J. Becher, MD * Cancer Research Hedgehog pathway inhibitors in basal “Regional differences in central nervous Professor of Medicine cell carcinomas” with Philip A. Beachy, New York system gliomagenesis” with Darell Division of Hematology and Oncology PhD, and Ervin H. Epstein, MD, Stanford D. Bigner, MD, PhD, and Katherine E. University of Pittsburgh School Sarat Chandarlapaty, University, Stanford Warren, MD, Duke University, Durham of Medicine MD, PhD * “Therapeutic approaches to PI3K-AKT- Pittsburgh, Pennsylvania Connecticut mTOR feedback pathways in breast cancer” with Neal Rosen, MD, PhD, and Texas Patricia A. Ganz, MD Tobias J.E. Carling, MD, PhD Clifford A. Hudis, MD, Memorial Sloan- Director, Division of Cancer Prevention Doris Duke-Damon Ralph J. DeBerardinis, Kettering Cancer Center, New York and Control Research Runyon Clinical Investigator MD, PhD Jonsson Comprehensive Cancer Center “Molecular genetics of endocrine tumor “Translational studies in cancer Professor, Schools of Medicine and disease” with Richard P. Lifton, MD, PhD, Igor Matushansky, MD, PhD metabolism” with Helen H. Hobbs, Public Health and Robert Udelsman, MD, MBA, Yale Gordon Family Clinical Investigator MD, University of Texas Southwestern University of California, Los Angeles University School of Medicine, “Implementing and imaging epigenetic Medical Center, Dallas Los Angeles, California New Haven based differentiation therapy for solid tumors” with Carlos Cordon-Cardo, MD, PhD, Columbia University, New York Utah Philip D. Greenberg, MD Massachusetts Director, Immunology Program Kevin B. Jones, MD * Ryan B. Corcoran, MD, PhD * Member, Fred Hutchinson Cancer Zsofia K. Stadler, MD “The mitochondrial apoptosis pathway “Defining novel targeted therapy “Characterization of de novo germline Research Center in synovial sarcoma” with Mario R. combination strategies for BRAF V600 genetic alterations in cancer Professor of Medicine and Immunology Capecchi, PhD, and Sunil Sharma, MD, mutant colorectal cancer” with Jeffrey susceptibility” with Kenneth Offit, MD, University of Washington University of Utah, Salt Lake City A. Engelman, MD, PhD, and Keith T. Seattle, Washington MPH, and Michael H. Wigler, PhD, Flaherty, MD, Massachusetts General Memorial Sloan-Kettering Cancer Center,
Hospital, Boston New York
2012 annual report / 26
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Joshua D. Schiffman, MD Brian G. Till, MD This program is supported by “Microsatellite length and integrin Pfizer Clinical Investigator founding sponsor Eli Lilly and signaling as risk factors for Ewing's “Optimization of adoptive Company in addition to Ariad, Sarcoma” with Stephen L. Lessnick, MD, immunotherapy for lymphoma using Celgene, Genentech, Merck, PhD, University of Utah, Salt Lake City genetically modified CD20-specific T Millennium: The Takeda Oncology cells” with Oliver W. Press, MD, PhD, Company, Pfizer and PhRMA, all Fred Hutchinson Cancer Research of which are members of Washington Center, Seattle Accelerating Cancer Cures. SPONSORed Awards Marie Bleakley, MD, PhD Richard A. Lumsden * Initial Award Wisconsin The following awards are funded by dedicated supporters of the Damon Runyon Cancer Foundation Investigator Research Foundation who have generously endowed an award in perpetuity or sponsored an “Segregating the GVL effect from GVHD Kevin R. Kozak, MD, PhD in humans” with Stanley R. Riddell, Genentech Clinical Investigator individual Damon Runyon scientist: MD, Fred Hutchinson Cancer Research “Radiosensitization with antiangiogenic Center, Seattle therapy” with Paul M. Harari, MD, University of Wisconsin, Madison Fellows Amgen Fellow Costas A. Lyssiotis, PhD Beth Israel Deaconess Medical Center Damon Runyon Boston, Massachusetts Clinical Investigator Award CONTINUATION GRANTS Marion Abbe Fellow * Sumeet Sarin, PhD Massachusetts New Jersey Washington Harvard University Cambridge, Massachusetts Rachael A. Clark, MD, PhD Vassiliki Karantza, MD, PhD Elahe A. Mostaghel, MD, PhD “Merkel cell polyomavirus specific T cells “Autophagy as a therapeutic target in Genentech Clinical Investigator Robert Black Fellows in human Merkel cell carcinomas” with breast cancer treatment” with Robert “Defining and exploiting molecular Kimberley Evason, MD, PhD Thomas S. Kupper, MD, Brigham and S. DiPaola, MD, UMDNJ/Robert Wood mechanisms of androgen metabolism University of California Women's Hospital, Boston Johnson Medical School, New Brunswick for prostate cancer therapy” with Peter San Francisco, California S. Nelson, MD, Fred Hutchinson Cancer Andrew T. Chan, MD, MPH Research Center, Seattle North Carolina Tom A. Hartl, PhD “Molecular imaging of colorectal Stanford University School of Medicine neoplasia” with Charles S. Fuchs, MD, William Y. Kim, MD The Continuation Grant Program is Stanford, California MPH, and Ralph Weissleder, MD, PhD, Merck Clinical Investigator supported by the William K. Bowes, Jr. Massachusetts General Hospital, Boston “Defining synthetic lethal targets of Foundation and Connie and Bob Lurie. David G. Hendrickson, PhD mTOR inhibition in renal cell carcinoma” Harvard University with Charles M. Perou, PhD, and Norman Minnesota Cambridge, Massachusetts E. Sharpless, MD, University of North Andrew L. Feldman, MD Carolina, Chapel Hill Lara C. Skwarek, PhD “Role of novel TP63 fusion genes University of California in IRF4-positive peripheral T-cell Berkeley, California lymphoma” with Stephen M. Ansell, MD, PhD, and Ahmet Dogan, MD, PhD, Yanling Wang, PhD Mayo Clinic, Rochester University of California Los Angeles, California
Accelerating Cancer Cures is a five-year, multi-million Dennis and Marsha Dammerman Fellow * Sarah E. Ewald, PhD dollar project that will train a new generation of exceptional Stanford University School of Medicine clinical investigators capable of translating the latest Stanford, California scientific discoveries into new diagnostics and therapeutics Fraternal Order of Eagles Fellow * for patients. The initiative also fosters communication and collaboration between academia and James P. Scott-Browne, PhD industry. Accelerating Cancer Cures is sponsored by some of the world’s leading companies, La Jolla Institute for Allergy including: Ariad, Eli Lilly and Company, Celgene, Genentech, Merck, Millennium: The Takeda and Immunology Oncology Company, Pfizer, and the Pharmaceutical Research and Manufacturers of America La Jolla, California (PhRMA). For more information, visit www.damonrunyon.org/accelerate. Dale F. and Betty Ann Frey Fellows * Maria Genander, PhD The Rockefeller University New York, New York
27 / damon runyon cancer research foundation
241794_SS_R1.indd 28 10/27/12 12:56 AM Damon Runyon Clinical Investigator AwardS
This program is supported by founding sponsor Eli Lilly and Company in addition to Ariad, Celgene, Genentech, Merck, Millennium: The Takeda Oncology Company, Pfizer and PhRMA, all of which are members of Accelerating Cancer Cures. SPONSORed Awards * Initial Award The following awards are funded by dedicated supporters of the Damon Runyon Cancer Research Foundation who have generously endowed an award in perpetuity or sponsored an individual Damon Runyon scientist:
Fellows Jason A. Hall, PhD Katarina Moravcevic, PhD New York University School of Medicine University of Pennsylvania School Amgen Fellow New York, New York of Medicine Costas A. Lyssiotis, PhD Philadelphia, Pennsylvania Beth Israel Deaconess Medical Center Sally Gordon Fellow Boston, Massachusetts Michael E. Pacold, MD, PhD Dale Muzzey, PhD Whitehead Institute for University of California Marion Abbe Fellow * Biomedical Research San Francisco, California Sumeet Sarin, PhD Cambridge, Massachusetts Harvard University Washington Erin A. Osborne, PhD Cambridge, Massachusetts Elahe A. Mostaghel, MD, PhD Howard Hughes Medical Institute Fellows The University of North Carolina Genentech Clinical Investigator Leon Y. Chan, PhD Chapel Hill, North Carolina Robert Black Fellows “Defining and exploiting molecular University of California Kimberley Evason, MD, PhD Berkeley, California Renee Otten, PhD mechanisms of androgen metabolism University of California Brandeis University for prostate cancer therapy” with Peter San Francisco, California S. Nelson, MD, Fred Hutchinson Cancer Elizabeth M. Duncan, PhD Waltham, Massachusetts Stowers Institute for Medical Research Research Center, Seattle Tom A. Hartl, PhD Kansas City, Missouri Maximilian W. Popp, PhD Stanford University School of Medicine University of Rochester School of The Continuation Grant Program is Stanford, California supported by the William K. Bowes, Jr. Nicholas R. Guydosh, PhD Medicine and Dentistry Foundation and Connie and Bob Lurie. The Johns Hopkins University Rochester, New York David G. Hendrickson, PhD Baltimore, Maryland Harvard University Lisa R. Racki, PhD Cambridge, Massachusetts Christopher J. Hale, PhD California Institute of Technology University of California Pasadena, California Lara C. Skwarek, PhD Los Angeles, California University of California Yoko Shibata, PhD Berkeley, California Melanie Issigonis, PhD Northwestern University University of Illinois Evanston, Illinois Yanling Wang, PhD Urbana, Illinois University of California Michael J. Smanski, PhD Los Angeles, California Björn F.C. Kafsack, PhD Massachusetts Institute of Technology Princeton University Cambridge, Massachusetts Dennis and Marsha Dammerman Fellow * Accelerating Cancer Cures is a five-year, multi-million Princeton, New Jersey Sarah E. Ewald, PhD Duncan J. Smith, PhD dollar project that will train a new generation of exceptional Stanford University School of Medicine Yumi Kim, PhD Memorial Sloan-Kettering Cancer Center Stanford, California clinical investigators capable of translating the latest University of California New York, New York scientific discoveries into new diagnostics and therapeutics Berkeley, California Fraternal Order of Eagles Fellow * for patients. The initiative also fosters communication and collaboration between academia and Lora B. Sweeney, PhD James P. Scott-Browne, PhD Rebecca S. Mathew, PhD Salk Institute industry. Accelerating Cancer Cures is sponsored by some of the world’s leading companies, La Jolla Institute for Allergy Harvard Medical School La Jolla, California and Immunology including: Ariad, Eli Lilly and Company, Celgene, Genentech, Merck, Millennium: The Takeda Boston, Massachusetts Oncology Company, Pfizer, and the Pharmaceutical Research and Manufacturers of America La Jolla, California Alexander Ward, PhD Raymond E. Moellering, PhD Stanford University School of Medicine (PhRMA). For more information, visit www.damonrunyon.org/accelerate. Dale F. and Betty Ann Frey Fellows * The Scripps Research Institute Stanford, California Maria Genander, PhD La Jolla, California The Rockefeller University Stephanie C. Weber, PhD New York, New York Princeton University Princeton, New Jersey
2012 annual report / 28
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Dong Yan, PhD Maurizio Righini, PhD Gordon Family Clinical Investigator Harvard Medical School University of California Igor Matushansky, MD, PhD OUR CONTRIBUTORS Boston, Massachusetts Berkeley, California Columbia University New York, New York Qiong Yang, PhD Ian Y. Wong, PhD The Damon Runyon Cancer Research Foundation acknowledges the generosity and Stanford University School of Medicine Massachusetts General Hospital Lilly Clinical Investigator support of the many individual, corporate and foundation donors who supported our Stanford, California Boston, Massachusetts N. Lynn Henry, MD, PhD University of Michigan brilliant researchers through gifts to the Foundation from July 1, 2011 to June 30, Hyun Youk, PhD Philip O’Bryan Ann Arbor, Michigan 2012.* Those whose individual lifetime giving is $100,000 or more are highlighted. University of California Montgomery, Jr., MD, Fellow * San Francisco, California Deniz Simsek, PhD Richard A. Lumsden We are especially grateful to these extraordinarily generous and committed donors. University of California Foundation Investigator Harry Kriegel Fellow San Francisco, California Marie Bleakley, MD $1,000,000 or more Scott J. Valastyan, PhD Fred Hutchinson Cancer Research Center Harvard Medical School Miles S. Nadal Fellow Seattle, Washington Estate of Dorothy H. Cottrell Boston, Massachusetts Shijing Luo, PhD Howard Hughes Medical Institute The Rockefeller University Merck Clinical Investigator Ira Sohn Conference Foundation, Inc. Rebecca Ridley KryF ellow * New York, New York William Y. Kim, MD Calvin H. Jan, PhD University of North Carolina $100,000 - $999,999 University of California Fayez Sarofim Fellow * Chapel Hill, North Carolina Anonymous (2) San Francisco, California Kristin A. Krukenberg, PhD Terry and David Beirne Harvard Medical School Pfizer Clinical Investigator Robert Black Charitable Foundation Kenneth G. and Elaine A. Langone Fellow * Boston, Massachusetts Brian G. Till, MD Pedro J. Batista, PhD Fred Hutchinson Cancer Research Center William K. Bowes, Jr. Foundation Stanford University School of Medicine Lallage Feazel Wall Fellow * Seattle, Washington Celgene Corporation Stanford, California Ying Lu, PhD Estate of Adrienne & Harry Harvard Medical School Chamberlain Norman B. Leventhal Fellow Boston, Massachusetts Innovators Leon & Toby Cooperman Foundation Daniel Schmidt, PhD Island Outreach Foundation Innovator Genentech, Inc. Massachusetts Institute of Technology The Jake Wetchler Foundation Fellows Raffaella Sordella, PhD Mr. Michael L. Gordon Cambridge, Massachusetts for Pediatric Innovation Cold Spring Harbor Laboratory Independent Charities of America Anne H. Bothmer, PhD Cold Spring Harbor, New York Island Outreach Foundation Connie and Bob Lurie Fellow * Beth Israel Deaconess Medical Center Estate of Burton H. Ladensohn David K. Breslow, PhD Boston, Massachusetts Nadia’s Gift Foundation Innovator Sherry and Alan Leventhal Family Stanford University School of Medicine Gregory L. Beatty, MD, PhD Foundation Stanford, Calfornia Hua Lu, PhD University of Pennsylvania Lilly USA, LLC The Scripps Research Institute Philadelphia, Pennsylvania Richard A. Lumsden Foundation Merck Fellows La Jolla, California Connie and Bob Lurie Gira Bhabha, PhD The Damon Runyon-Rachleff Merck & Company, Inc. University of California Suzanne and Bob Wright Fellow * Innovation Award is funded by the San Francisco, California Nathan D. Thomsen, PhD generous support of Debra and Andrew Millennium: The Takeda Oncology University of California S. Rachleff. Please refer to pages 24-25 Company Angela N. Brooks, PhD San Francisco, California for a list of Innovators. Miles S. Nadal and Family Dana-Farber Cancer Institute Nadia's Gift Foundation
Boston, Massachusetts * In perpetuity Robert Leet and Clara Guthrie Clinical Investigators Patterson Trust Gabriel C. Lander, PhD Genentech Clinical Investigators Pfizer Inc. Lawrence Berkeley National Laboratory Kevin R. Kozak, MD, PhD Debra and Andrew S. Rachleff Berkeley, California University of Wisconsin The Jake Wetchler Foundation Madison, Wisconsin Wan-Jin Lu, PhD $50,000 - $99,999 Stanford University School of Medicine Elahe A. Mostaghel, MD, PhD Stanford, California Fred Hutchinson Cancer Research Center Angelo, Gordon & Co. Seattle, Washington Ariad Pharmaceuticals, Inc. Estate of John Dayoe Erlbaum Family Foundation Mr. Steve Hayden Mr. W. Barry McCarthy, Jr. MetLife MetLife Foundation Charles Offin Charitable Trust Louis and Rachel Rudin Foundation, Inc. Mrs. Mary Vetter
*Our donor lists are checked carefully. However, if you have any corrections or questions, please call 877.722.6237. 29 / damon runyon cancer research foundation The full pledge amount is listed in the year the pledge is made. In subsequent years, actual pledge payments are listed.
241794_SS_R1.indd 30 10/27/12 12:56 AM Gordon Family Clinical Investigator Igor Matushansky, MD, PhD Columbia University OUR CONTRIBUTORS New York, New York The Damon Runyon Cancer Research Foundation acknowledges the generosity and Lilly Clinical Investigator support of the many individual, corporate and foundation donors who supported our N. Lynn Henry, MD, PhD University of Michigan brilliant researchers through gifts to the Foundation from July 1, 2011 to June 30, Ann Arbor, Michigan 2012.* Those whose individual lifetime giving is $100,000 or more are highlighted.
Richard A. Lumsden We are especially grateful to these extraordinarily generous and committed donors. Foundation Investigator Marie Bleakley, MD $1,000,000 or more $25,000 - $49,999 Interco Charitable Trust Fred Hutchinson Cancer Research Center Mr. Steven A. Kandarian Estate of Dorothy H. Cottrell Amgen, Inc. Seattle, Washington Mr. Kevin G. Keyes Howard Hughes Medical Institute John M. and Judy Hart Angelo Mr. Orin Kramer Ira Sohn Conference Foundation, Inc. Clayman Family Foundation Merck Clinical Investigator Mr. and Mrs. Kenneth G. Langone Estate of Rita Eisenberg William Y. Kim, MD Mr. Thomas H. Lee and Ms. $100,000 - $999,999 Grand Aerie Fraternal Order of Eagles University of North Carolina Ann Tenenbaum Chapel Hill, North Carolina Hettinger Foundation Anonymous (2) Lockton Companies, LLC The Illini 4000 for Cancer Terry and David Beirne Mr. and Mrs. Henry Mannix III Pfizer Clinical Investigator Mr. and Mrs. Jay Ireland Robert Black Charitable Foundation Ms. Mary Meeker Brian G. Till, MD Mr. and Mrs. Norman Leventhal William K. Bowes, Jr. Foundation Gordon H. & Karen M. Millner Fred Hutchinson Cancer Research Center Mr. and Mrs. David G. Marshall Celgene Corporation Family Foundation Seattle, Washington MDC Partners Estate of Adrienne & Harry The Leo Model Foundation, Inc. Dunlevy Milbank Foundation, Inc. Chamberlain Eugene & Mary Murphy Charitable Gift Fund Mr. and Mrs. Cecil Powers Innovators Leon & Toby Cooperman Foundation Pavarini McGovern Mr. Scott Ryles Island Outreach Foundation Innovator Genentech, Inc. Pyramid Hotel Group Select Equity Group Raffaella Sordella, PhD Mr. Michael L. Gordon Raiff Foundation Cold Spring Harbor Laboratory Independent Charities of America Mr. and Mrs. Arthur J. Samberg $10,000 - $24,999 Cold Spring Harbor, New York Island Outreach Foundation Ms. Karen D. Seitz Estate of Burton H. Ladensohn 24 Hour Fitness Henry J. & Kathleen Singer Nadia’s Gift Foundation Innovator Sherry and Alan Leventhal Family 72andSunny Partners LLC Family Foundation Gregory L. Beatty, MD, PhD Foundation Mr. Robert J. Alexander, CBRE Charles Spear Charitable Trust University of Pennsylvania Lilly USA, LLC Casey, Brooke, Drew, Joan and Barbara & Peter Strauss Philadelphia, Pennsylvania Richard A. Lumsden Foundation Lawrence Altman Advised Fund Philanthropic Fund Connie and Bob Lurie Mr. and Mrs. Lawrence Altman TargetCast tcm The Damon Runyon-Rachleff Merck & Company, Inc. Anonymous The T.F. Trust Innovation Award is funded by the Mrs. Barbara Lieb Baumstein generous support of Debra and Andrew Millennium: The Takeda Oncology Tzedakah Foundation S. Rachleff. Please refer to pages 24-25 Company BDO USA, LLP Ueberroth Family Foundation for a list of Innovators. Miles S. Nadal and Family Sol & Margaret Berger Foundation Greg Welch, Spencer Stuart Nadia's Gift Foundation Brick-Run Sports Physical Therapy, White Rose * In perpetuity Robert Leet and Clara Guthrie PLLC Wickham Family Fund Patterson Trust The Channing Family Mr. Peter J. Worth Pfizer Inc. Robert M. Currey & Associates, Inc. Debra and Andrew S. Rachleff Cushman & Wakefield $5,000 - $9,999 The Jake Wetchler Foundation Davis & Gilbert LLP Mrs. Carolyn R. Aller Debevoise & Plimpton LLP Aurora Capital Group $50,000 - $99,999 Diane von Furstenberg Studio L.P. Estate of William Borea Lorraine and Bill Egan Angelo, Gordon & Co. Mr. Richard L. Bowen Mr. and Mrs. Michael R. Eisenson Ariad Pharmaceuticals, Inc. Bruce Mau Design EOG Resources, Inc. Estate of John Dayoe Chelsea Lighting, Inc. Mr. and Mrs. Michael C. Erlbaum Erlbaum Family Foundation Mr. Laurence W. Cohen The Fine & Greenwald Foundation, Inc. Mr. Steve Hayden Mr. and Mrs. Martin J. Cohen First American Title Mr. W. Barry McCarthy, Jr. Mr. and Mrs. James J. Costello Insurance Company MetLife Creative Dimensions Betty Ann and Dale Frey MetLife Foundation The Cunningham Foundation GE Asset Management Charles Offin Charitable Trust Mr. Mitchell Jennings and Ms. Mr. and Mrs. James Gould Louis and Rachel Rudin Elizabeth B. Dater Goulston & Storrs, P.C. Foundation, Inc. Mr. and Mrs. Michael DeDomenico Mr. and Mrs. Scott Greenstein Mrs. Mary Vetter Mr. and Mrs. Frank Doyle Irma T. Hirschl Charitable Trust Duval & Stachenfeld LLP HL Group
*Our donor lists are checked carefully. However, if you have any corrections or questions, please call 877.722.6237. The full pledge amount is listed in the year the pledge is made. In subsequent years, actual pledge payments are listed. 2012 annual report / 30
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Echlin Foundation Ms. Velma M. Anderson Mrs. Vesta Edwards Mr. and Mrs. Wayne M. Hummel Mr. Martin L. Edelman Anonymous (2) Elite Promotions, Inc. Mr. Patrick M. Hurless and Ms. Megan K. Mr. and Mrs. Steven Einhorn Apple Lane Foundation Mr. and Mrs. James M. Emanuele Curran-Hurless LaRue S. & Walter F. Fisher Mrs. Joan Armour-Mendell Endo Pharmaceuticals Inc. Mr. and Mrs. Edward Hyman Memorial Trust Mr. and Mrs. Jeff Aronson Enzon Pharmaceutical Mr. Remy Isdaner Mr. and Mrs. William Fisher The Bachmann-Strauss Family Estate of Edward & Bozena Etnyre Mr. and Mrs. Christopher Jensen Friedman Family Foundation Fund, Inc. Mr. Robert Ettl Johnson & Johnson Mr. Frederic B. Gershon Mr. William M. Backstrom, Jr. Ms. Erica K. Evans Johnson-Miller Foundation Estate of Elsinore Machris Gilliland Ms. Charlotte D. Bakst Mrs. Marilyn H. Ezzes Ms. Silky Kamdar Mr. and Mrs. Jim Gordon, The Mr. Mike Balkin Thomas J. Fahey, Jr., MD Mr. Earle W. Kazis Edgewater Funds Bank of America Matching Gifts Mr. and Mrs. Michael D. Fascitelli Ms. Marjorie Kellner Heitman LLC Mrs. Laura Z. Barket Mr. Ralph A. Fields Mr. and Mrs. James H. Kimenker Mr. and Mrs. Albert Hess The Howard Bayne Fund Mrs. Roberta Fine Dr. Stacie Kiratsous and Mr. Stephan Mr. Clair Howey/Maryann Howey Mr. and Mrs. Steven H. Berg FINRA Kiratsous Memorial Fund Mr. Jason Berger Ms. Sue Firestone, sfa design Ms. Lisa F. Kirkpatrick ING Foundation The Len & Laura Berlik Foundation, Inc. Robert F. Fisher, PhD Mr. and Mrs. Phil Koen J.I. Foundation, Inc. Mr. and Mrs. Charles A. Bernheim Mr. Thomas Florkowski Mr. and Mrs. Jeremy R. Kramer Mr. and Mrs. Stephen E. Joseph Donald P. Biek, PhD Mr. Ronald Forster Estate of Marie Kronman Mr. and Mrs. Ed Kania BLL Foundation Mr. Harris Freedman Mr. Kevin Krupski Mr. and Mrs. Seth A. Klarman Mr. and Mrs. Eugene K. Bolton Mr. and Mrs. Buck French Mr. and Mrs. Stig A. Kry Mr. David Lambert Mr. and Mrs. Lawrence A. Bossidy Ms. Mary Ann Frenzel Mr. and Mrs. John Lancaster The Lichtenberger Foundation Mr. and Mrs. Thomas J. Bracken Mrs. Mary Ann Fribourg Ms. Ellen S. Lane Maverick Capital Charities Mr. William S. Brady Mr. and Mrs. Michael Frieze Ms. Janice R. Lane City of Baltimore Combined brightroom, Inc. Elaine V. Fuchs, PhD William D. & E.M. Lane Foundation Charity Campaign Mr. and Mrs. Richard E. Bruce Gabelli Funds Mr. Alex Lee Mr. and Mrs. Robert M. Melzer Judy Buechner Advised Fund Mr. and Mrs. Robert W. Garthwait, Sr. Mrs. Ann R. Lermer Mr. and Mrs. Warren K. Myer Mr. Frank M. Bumstead Ms. Janet Gelbart Levin Capital Strategies, LP Mr. and Mrs. John H. Myers Steven J. Burakoff, MD General Electric Foundation Ms. Ann E. Levine Narragansett School System Mr. and Mrs. Dennis Burke Ms. Ruth E. Gitlin Mr. Jonathan Levinson New York State Industries for the Mr. and Mrs. Patrick J. Callan Mr. Gary Gitnick Levy Family Philanthropic Fund Disabled (NYSID) Mrs. Christina E. Carroll Goldman Sachs Matching Gift Program Estate of Franklin S. Lewis Palisade Capital Management, LLC William L. Carroll, MD Ms. Lois Goldring Mr. Steven Lightman Peco Foundation Mr. Edward Cherney Mr. Mark A. Goldsmith Linden Motor Freight Company, Inc. The Price Family Foundation, Inc. The Chubb Corporation Todd R. Golub, MD Mr. Robert E. Linton Q Sport Architects Estate of Laurelia M. Clifford Mr. and Mrs. Todd Graham Mr. and Mrs. Sy Richard Lippman Mrs. Elizabeth B. Ross Mr. David Cocciolone Ms. Elizabeth A. Gray David M. Livingston, MD Sabadell Bank & Trust Ms. Angela Coffee Patrick William Gray, PhD Mr. Elliot H. Loden Mr. Marvin C. Schwartz Mr. and Mrs. Jay L. Cohan Ms. Elizabeth Greif Anthony F. LoFrisco, Esq. SEFA of Maryland Mr. and Mrs. Raymond S. Cohen Ms. Patricia Grenfell Mr. and Mrs. Curtis Louie Stewart Senter, Inc. Mr. and Mrs. Maurice J. Cohn Mr. Anthony A. Grey Mr. and Mrs. Richard B. Loynd Ms. Suzy Sang Shechtman Mr. and Mrs. Stephen P. Colman Mr. Justin Griffiths Mrs. Barbara Macklowe The Richard C. and Theresa P. Smith Errol M. & Gladys Cook Fund Mr. and Mrs. Vernon Grizzard Mr. Richard H. Maidman Memorial Fund Mr. Patrick Corker Mrs. Ina Haas Henri Emile Maisin, MD, PhD Mrs. Mikell M. Smith Ms. Sondra Cristal Mr. and Mrs. David Lee Hamilton Mr. James H. Manges Mr. James D. Staley Mr. James L. Currie Mr. I.H. Hammerman II Mr. Jim Mara Mr. and Mrs. Dan Stanton Ms. Dorothy D'Amato Ms. Penelope P. Harris Marsh USA, Inc. Thrive Capital Mr. Lawrence H. David Mr. and Mrs. Jed Hart Mr. and Mrs. Gerald M. Marshall Structure Tone Mrs. Lorinda DeRoulet Mr. and Mrs. Robert L. Harteveldt Mr. Bruce Martin Mr. Daniel J. Thompson, Jr. Mr. and Mrs. Philip DeToledo Mr. John H. F. Haskell, Jr. Mrs. William Matheson Daniel P. & Grace I. Tully Dr. Barbara G. Deutsch Mr. and Mrs. Robert Haupt Estate of August Mattheyses Fund Charitable Trust Mr. and Mrs. Timothy W. Diggins Healey Family Foundation MB Real Estate The Turk Family Foundation Mrs. Rose DiMarco Mr. and Mrs. Bill Heater Mr. John McStay Werner Family Foundation Mr. Melvin Dion Lenore Hecht Foundation, Inc. Mrs. Janet Menn Edwards Estate of Winifred Wiederkerr Mr. John Dolan Mr. and Mrs. Robert M. Hess The Messinger Foundation, Inc. Mr. and Mrs. Gary Wolf Ms. Marjorie Doniger Mr. and Mrs. Lawrence C. Hoff Mr. and Mrs. Fred Middleton Mr. Craig A. Drill Mr. Richard A. Hoffman and Ms. Laura Miller $1,000 - $4,999 Mr. and Mrs. Larry D. Droppa Ms. Lisa Gross Mr. and Mrs. Stanley T. Miller Mrs. Willis H. DuPont Mr. Michael Hommeyer Ms. Elaine M. Addis Mr. Michael Milton Mr. Michael L. Dweck Mr. and Mrs. Edward E. Hood, Jr. Mr. Gerald N. Agranoff Mr. Alan Mirken Mr. and Mrs. Daniel Ebenstein Ms. Sandra J. Horbach Mr. Ben Alexander Sanford W. Morhouse, Esq. Mrs. Jennifer Eddington Mr. and Mrs. Daniel Huber Allison+Partners Mr. and Mrs. Charles H. Murphy III
31 / damon runyon cancer research foundation
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Mrs. Vesta Edwards Mr. and Mrs. Wayne M. Hummel Mr. James K. Murray, Jr. Mr. Roger A. Shiffman Elite Promotions, Inc. Mr. Patrick M. Hurless and Ms. Megan K. Mr. and Mrs. W. Stephen Murray The Sidewater Family Foundation, Inc. Mr. and Mrs. James M. Emanuele Curran-Hurless Ms. Sue Nager Joseph M. Siegman Family Foundation Endo Pharmaceuticals Inc. Mr. and Mrs. Edward Hyman National Mah Jongg League, Inc. Mr. and Mrs. David M. Silfen Enzon Pharmaceutical Mr. Remy Isdaner Dr. Herbert E. Natof Mr. and Mrs. Harvey Silverman Estate of Edward & Bozena Etnyre Mr. and Mrs. Christopher Jensen Mr. and Mrs. Thomas J. Neff Ms. Andrea L. Silverstein Mr. Robert Ettl Johnson & Johnson The Neisloss Family Foundation, Inc. Samuel C. Silverstein, MD Ms. Erica K. Evans Johnson-Miller Foundation Network For Good Mr. and Mrs. Jeffrey Q. Smith Mrs. Marilyn H. Ezzes Ms. Silky Kamdar Neu Foundation of California, Inc. Estate of Lidie Anne Smith Thomas J. Fahey, Jr., MD Mr. Earle W. Kazis L.M. Newman Family Foundation Estate of Mildred A. Smith Mr. and Mrs. Michael D. Fascitelli Ms. Marjorie Kellner Mr. William W. Nicholson Mr. Jay Snyder Mr. Ralph A. Fields Mr. and Mrs. James H. Kimenker Mr. and Mrs. Michael J. Nohe Mr. Bill Spoor Mrs. Roberta Fine Dr. Stacie Kiratsous and Mr. Stephan Ocean State Job Lot Ms. Aliana B. Spungen FINRA Kiratsous Charitable Foundation Mr. and Mrs. Kenneth M. Stabler Ms. Sue Firestone, sfa design Ms. Lisa F. Kirkpatrick Mrs. William J. Oppenheim Mrs. Linda B. Stern Robert F. Fisher, PhD Mr. and Mrs. Phil Koen Richard J. O'Reilly, MD Bruce W. Stillman, PhD, FRS Mr. Thomas Florkowski Mr. and Mrs. Jeremy R. Kramer Mr. Andrew Parks Martha Washington Straus - Harry Mr. Ronald Forster Estate of Marie Kronman Mr. Gerald L. Parsky Straus Foundation, Inc. Mr. Harris Freedman Mr. Kevin Krupski Mr. Gordon B. Pattee Philip & Lynn Straus Mr. and Mrs. Buck French Mr. and Mrs. Stig A. Kry Mr. Stephen Patterson Foundation, Inc. Ms. Mary Ann Frenzel Mr. and Mrs. John Lancaster Mr. Gerald S. Payne Mr. and Mrs. Melville Straus Mrs. Mary Ann Fribourg Ms. Ellen S. Lane Mr. Steven S. Payson Mr. and Mrs. James Studer Mr. and Mrs. Michael Frieze Ms. Janice R. Lane Mr. and Mrs. Robert M. Pennoyer Ms. Judy C. Swanson Elaine V. Fuchs, PhD William D. & E.M. Lane Foundation Mr. Chuck Porter Ms. Karen Tate Gabelli Funds Mr. Alex Lee Ms. Elizabeth M. Portland and Mr. Ms. Adina Taubman Mr. and Mrs. Robert W. Garthwait, Sr. Mrs. Ann R. Lermer Thomas Toce Mr. and Mrs. Sanford V. Teplitzky Ms. Janet Gelbart Levin Capital Strategies, LP Ms. Linda Powers Craig B. Thompson, MD General Electric Foundation Ms. Ann E. Levine Mr. Richard G. Prescott Mr. and Mrs. Michael J. Tine Ms. Ruth E. Gitlin Mr. Jonathan Levinson Mr. Sheldon Pressler Mr. John L. Tishman Mr. Gary Gitnick Levy Family Philanthropic Fund Mr. and Mrs. Robert P. Quinn Mrs. Christine Toretti Goldman Sachs Matching Gift Program Estate of Franklin S. Lewis Mrs. Aline Raisler Mr. and Mrs. Donald W. Torey Ms. Lois Goldring Mr. Steven Lightman Harold K. Raisler Foundation Mr. and Mrs. John M. Trani Mr. Mark A. Goldsmith Linden Motor Freight Company, Inc. Ms. Virginia H. Randt Mr. and Mrs. Jerome Turk Todd R. Golub, MD Mr. Robert E. Linton Mr. and Mrs. Richard C. Rantzow UBS Matching Gift Program Mr. and Mrs. Todd Graham Mr. and Mrs. Sy Richard Lippman Mr. and Mrs. Carl A. Ressa, Jr. United Way of Southeastern Ms. Elizabeth A. Gray David M. Livingston, MD Mr. Philip A. Riordan Pennsylvania Patrick William Gray, PhD Mr. Elliot H. Loden Mr. and Mrs. D. Paul Rittmaster Mr. Scott Urdang Ms. Elizabeth Greif Anthony F. LoFrisco, Esq. Mr. Larry Robbins Mr. Kenneth Usdin Ms. Patricia Grenfell Mr. and Mrs. Curtis Louie Mr. Mike Robbins Ms. Frances Uzansky Mr. Anthony A. Grey Mr. and Mrs. Richard B. Loynd Mr. and Mrs. Gary R. Rockhold Mr. Gene Vignola Mr. Justin Griffiths Mrs. Barbara Macklowe Ms. Jessica Rodman Visa GivingStation Mr. and Mrs. Vernon Grizzard Mr. Richard H. Maidman Gary N. Rogers, PhD Ms. Joni L. Walser and Mrs. Ina Haas Henri Emile Maisin, MD, PhD Ms. Deborah S. Ross Mr. Andrew Church Mr. and Mrs. David Lee Hamilton Mr. James H. Manges Mrs. Miriam K. Rothenberg Warren E & P, Inc. Mr. I.H. Hammerman II Mr. Jim Mara Mr. Philip R. Rotner Wasserman Foundation Ms. Penelope P. Harris Marsh USA, Inc. Ms. Barbara D. Salmanson Mr. and Mrs. Peter J. Wasserman Mr. and Mrs. Jed Hart Mr. and Mrs. Gerald M. Marshall Sanderson Family Charitable Fund Ms. Krista Webster, Veritas Mr. and Mrs. Robert L. Harteveldt Mr. Bruce Martin Dr. Lief Sannen and Communications Mr. John H. F. Haskell, Jr. Mrs. William Matheson Mr. Lawrence Wieman David and Candace Weir Foundation Mr. and Mrs. Robert Haupt Estate of August Mattheyses Fund Mr. and Mrs. Preston R. Sargent Mr. and Mrs. Arnold M. Weiss Healey Family Foundation MB Real Estate Mendon F. Schutt Family Fund Geraldine Louise Wheatley Mr. and Mrs. Bill Heater Mr. John McStay Mr. and Mrs. Adam Schwartz Whitehead Institute Lenore Hecht Foundation, Inc. Mrs. Janet Menn Edwards Mr. Cary M. Schwartz Ms. Claire Wolfe Mr. and Mrs. Robert M. Hess The Messinger Foundation, Inc. Mr. Robert D. Scinto The Jonathan Wolff Charitable Fund Mr. and Mrs. Lawrence C. Hoff Mr. and Mrs. Fred Middleton Robert J. Seifer Cancer Research Mr. and Mrs. Rod C. Wood Mr. Richard A. Hoffman and Ms. Laura Miller Foundation Mrs. Betty G. Young Ms. Lisa Gross Mr. and Mrs. Stanley T. Miller William R. Sellers, MD Mr. and Mrs. Joseph A. Zaccagnino Mr. Michael Hommeyer Mr. Michael Milton Mrs. Felice K. Shea Mr. Seymour W. Zises, Family Mr. and Mrs. Edward E. Hood, Jr. Mr. Alan Mirken Ms. Nancy Shea Management Corporation Ms. Sandra J. Horbach Sanford W. Morhouse, Esq. Mr. and Mrs. Robert B. Shepler Mr. and Mrs. Daniel Huber Mr. and Mrs. Charles H. Murphy III Abraham I. & Jean Sherr Foundation, Inc.
2012 annual report / 32
241794_SS_R1.indd 33 10/27/12 12:56 AM Damon Runyon advisors
The Damon Runyon Advisors act as special advisors to the Foundation in their areas of expertise and are committed to expanding awareness about our important work to the next generation of supporters.
Jill E. Karen Fang John M. Olivieri Bargonetti-Chavarria, PhD Head of Cross Asset Solutions & Partner Professor of Biological Sciences Strategies for Global Markets White & Case LLP Hunter College and The Graduate Center Bank of America Merrill Lynch City University of New York Annemarie Schoepfer Jeremy Lack, PhD Senior Partner, Planning FINANCIAL SUMMARY Michael J. Bossidy Managing Director Ogilvy & Mather Worldwide Managing Director and Cortec Group Head of U.S. Distribution Marcel R. M. FISCAL YEAR 2012 JPMorgan Securities, Inc. Henry Mannix III van den Brink, MD, PhD As in previous years, the financial activities of the Damon Runyon Cancer Research Vice President Head, Division of Hematologic Oncology Deborah Clayman Kelso & Company Alan N. Houghton Chair in Immunology Foundation were audited by McGladrey and Pullen, LLP. Below is a snapshot of FY Clayman Family Foundation Memorial Sloan-Kettering Cancer Center 2012. For our complete audited financial statements, please visit our website at Gerald M. Marshall Erica K. Evans President and Chief Executive Officer Gary Wolf www.damonrunyon.org. EVP, Head of Sales & Marketing Amerimar Enterprises, Inc. Managing Director Hartford Investment Angelo, Gordon & Co. Management Company Christine L. O’Donnell Vice President and Senior Program Officer Total Operating Expenses Foundation Advisory Services Bank of America Merrill Lynch $15.5 Million
broadway premier circle
The Broadway Premier Circle is a group of committed Damon Runyon Broadway Tickets customers who have made a special donation in support of cancer research. The Premier Circle offers members priority access to tickets and other benefits.
Ms. Sandye Berger Ms. Ellen S. Lane Abraham I. & Jean Sherr Foundation, Inc. Mr. Frank M. Bumstead Mr. and Mrs. Gerald M. Marshall The Sidewater Family Foundation, Inc. Bonni Curran, MD Mr. Martin E. Messinger Mr. and Mrs. Kenneth M. Stabler Mr. James L. Currie Mr. and Mrs. Charles H. Murphy III Mrs. Barbara W. Stern Ms. Dorothy D'Amato Mr. James K. Murray, Jr. Mr. and Mrs. Michael J. Tine Mr. and Mrs. Philip DeToledo Ms. Sue Nager Mr. and Mrs. Jerome Turk Ms. Mary Ann Frenzel Mr. Sheldon Pressler Mr. Scott Urdang Ms. Penelope P. Harris Ms. Virginia H. Randt Mr. and Mrs. Peter J. Wasserman Mr. and Mrs. Robert Haupt Mr. Philip R. Rotner Mr. Benjamin J. Winter Mr. and Mrs. James H. Kimenker Mr. and Mrs. Ernest Scheller, Jr. SUMMARY OF BALANCE SHEETS
DISCOVERY SOCIETY Total Assets
Discovery Society members are valued supporters who have provided for the Damon Runyon Total Liabilities Cancer Research Foundation through planned gifts. These donations provide a vital source of support Total Net Assets and fuel future breakthroughs against cancer.
Ms. Elaine M. Addis Mr. and Mrs. William C. Hines Mr. and Mrs. Ronald E. Parr Ms. Ann K. Cote Mrs. Rebecca R. Kry Mr. Seymour Rosenheck Mrs. Phyllis Farleigh Mr. and Mrs. Leo LoFrisco Ms. Phoebe H. Showers Robert F. Fisher, PhD Mrs. Charles B. Marqusee Mrs. Carol H. Stix Ms. Mary Ann Frenzel Mr. D.G. Mitchell Ms. Rose Vaccariello Mr. Rick J. Govern Ms. Martha R. Nortner Mr. and Mrs. Arthur Walker
33 / damon runyon cancer research foundation
241794_SS_R1.indd 34 10/27/12 12:56 AM The Damon Runyon Advisors act as special advisors to the Foundation in their areas of expertise and are committed to expanding awareness about our important work to the next generation of supporters.
John M. Olivieri Partner White & Case LLP
Annemarie Schoepfer Senior Partner, Planning FINANCIAL SUMMARY Ogilvy & Mather Worldwide
Marcel R. M. FISCAL YEAR 2012 van den Brink, MD, PhD Head, Division of Hematologic Oncology As in previous years, the financial activities of the Damon Runyon Cancer Research Alan N. Houghton Chair in Immunology Foundation were audited by McGladrey and Pullen, LLP. Below is a snapshot of FY Memorial Sloan-Kettering Cancer Center 2012. For our complete audited financial statements, please visit our website at Gary Wolf www.damonrunyon.org. Managing Director Angelo, Gordon & Co.
Total Operating Expenses Total Support $15.5 Million $15.5 Million
General Administration
3.6% Fundraising The Broadway Premier Circle is a group of committed Damon Runyon Broadway Tickets customers 10.6% who have made a special donation in support of cancer research. The Premier Circle offers members Draw from Investments priority access to tickets and other benefits. 85.8% Award 26.0% Programs
Abraham I. & Jean Sherr Foundation, Inc. The Sidewater Family Foundation, Inc. Contributions Donated Services 63.0% 4.2% Mr. and Mrs. Kenneth M. Stabler Bequests & Mrs. Barbara W. Stern Trusts 3.8% Mr. and Mrs. Michael J. Tine Damon Runyon Broadway Tickets Mr. and Mrs. Jerome Turk 2.8% Mr. Scott Urdang Misc. Income Mr. and Mrs. Peter J. Wasserman 0.2% Mr. Benjamin J. Winter SUMMARY OF BALANCE SHEETS 2011 2012 Total Assets $106,487,205 $107,113,018
Discovery Society members are valued supporters who have provided for the Damon Runyon Total Liabilities $17,214,923 $19,474,980 Cancer Research Foundation through planned gifts. These donations provide a vital source of support Total Net Assets $89,272,282 $87,638,038 and fuel future breakthroughs against cancer.
Mr. and Mrs. Ronald E. Parr Mr. Seymour Rosenheck Ms. Phoebe H. Showers We are also fully Mrs. Carol H. Stix accredited by the Ms. Rose Vaccariello Better Business Bureau Mr. and Mrs. Arthur Walker Wise Giving Alliance.
241794_SS_R1.indd 35 10/27/12 12:56 AM One Exchange Plaza 55 Broadway, Suite 302 New York, New York 10006 1.877.7CANCER T 212.455.0500 F 212.455.0509 www.damonrunyon.org
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