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Haematology and Blood Transfusion Hamatologie Und Bluttransfusion 35 Rolf Neth Elena Frolova Robert C

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Haematology and Blood Transfusion Hamatologie Und Bluttransfusion 35 Rolf Neth Elena Frolova Robert C Haematology and Blood Transfusion Hamatologie und Bluttransfusion 35 Rolf Neth Elena Frolova Robert C. Gallo Melvyn F. Greaves Boris V. Afanasiev and Elena Elstner (Eds.) Modern Trends in Human Leukemia IX New Results in Clinical and Biological Research Including Pediatric Oncology Organized on behalf of the Deutsche Gesellschaft fUr Hamatologie und Onkologie, Wilsede, June 17-21,1990 With 194 Figures and 47 Tables Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest Dr. Rolf Neth Universitats-Krankenhaus Eppendorf, Zentrum fiir Knochenmark-Transplantation Martinistr. 52, 2000 Hamburg 20, FRO Dr. Elena Frolova Shemyakin Institute of Bioorganic Chemistry, Miklukho-Maklaya Str. 16/10, 117871 Moscow, Russia Dr. Robert C. Gallo National Cancer Institute, Laboratory of Tumor Cell Biology, Bethesda, MD 20205, USA Dr. Melvyn F. Greaves Leukemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW 3 6 JB, UK Dr. Boris V. Afanasiev N. N. Petrov Institute of Oncology, Department of Bone Marrow Transplantation, St. Petersburg, Russia Dr. Elena Elstner Medizinische Fakultat der Humboldt-Universitat Berlin, Klinik fUr Innere Medizin, Abteilung Hamatologie, Schumannstr. 20/21, 1040 Berlin, FRO ISBN-13: 978-3-540-54360-2 e-ISBN-13: 978-3-642-76829-3 DOl: 10.007/978-3-642-76829-3 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1992 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and applica­ tion contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Fotosatz-Service Kiihler, Wiirzburg, FRG 27/3145/-54321 0 - Printed on acid-free paper Volga Wilsede Meeting I Moskau / Volga 13.6.-15.6.1990 "Molecular Factors of Hematopoiesis" Organisation: Elena Frolova Gregory Dolganov Shemyakin Institute of Bioorganic Chemistry VI. Miklukho-Maklaya 16/10 Moscow Neva Wilsede Meeting I St. Petersburg 14.6.-17.6.1990 "Clinical Aspects" Organisation: Boris Afanasiev Peter Knyazev Bone Marrow Transplantation Institute of Oncology Leningradskay str. 68 St. Petersburg Wilsede Joint Meeting Hamburg 16.6.1990 "Signal Transfer Pathway" Organisation: Wolfram Ostertag Heinrich Pette Institut fUr Experimentelle Virologie und Immunologie an der Vniversihit Hamburg Martinistr. 52 2000 Hamburg 20 Local Organisation: Klaus Mannweiler Heinrich Pette Institut fUr Experimentelle Virologie und Immunologie an der Vniversitiit Hamburg Martinistr. 52 2000 Hamburg 20 Rolf Neth Zentrum fiir Knochenmark-Transplantation V niversi tii ts-Krankenha us E ppendorf Martinistr. 52 2000 Hamburg 20 Johannes Schubert St. Joseph Hospital Wiener Str. 1 2850 Bremerhaven v Ladies and Gentlemen, Dear Friends In 1988, after the last Wilsede meeting, Den v6lligen Gegensatz zum Antlitz Elena Frolova and her friends had the bildet das Wort Maske. marvelous idea of organizing a Volga Wilsede meeting. Today, I am very Pavel Florenski 1882-1937 in: pleased that this idea became true. "Die Ikonostase" Every day, we dream of freedom and peace. A small part of this dream has today come into our hands. Everybody here has done his best to come together for good science and in friendship. I am sure that this Volga Wilsede meeting and the Neva Wilsede Meeting will be­ come part of the international tradition of good science in a peaceful human atmosphere. For us this door IS open: let us go through. Moscow, 13 June 1990 Rolf Neth VII Dr. Rolf Neth asked me to say a few The upper picture which looks like a words about my last work, which I called Super Nova is a cell ofamouse fibroplast "Alexander Maximov's world". I could which Alexander Maximov in his time think that many of you had to learn or to could not see like this, as the electronic study his experiments and results, when microscope was'nt invented then. This is they were students. Well, I am not com­ the contemporary level of this work to­ petent enough to give a valuation of his gether with the circled Wilsede motif work or meaning in histology. But the over the tower. few things I read about his work and life If you look closer and I could help gave me a great deal of respect and everybody with my magnifying glass, you admiration. Specially how he drew and discover that Maximov's two blood pic­ painted the results of his experiments in tures are drawn in the silhouette of the such a filligran and precise way. Emhof (up side down) and the Granary. Amongst scientists, often the work of a The Center shows the portrait of colleague is not always considered with Alexander Maximov about the time as a great admiration rather more with a feel­ young man in St. Petersburg and it shows. ing of respect or competition. So, when I close to his heart the entrance to his labo­ put up some kind of a monument for ratory in the Military Academy. Alexander Maximov, it is the painters To end now, I sum up the key idea may admiration for a scientist, who probably be called 5 seconds of inspiration and five drew much better than I ever would do in weeks of rather hard work. Alexander histology. Maximov as a tower surrounded by the Now to my work: There is the real and real buildings St. Petersburg, Berlin and spiritual world of Alexander Maximov. Chicago and on the other hand sur­ The polarisation of the idea is seen on the rounded by his spiritual buildings, the right side which shows the three stations blood pictures in the silhouette of in his life. Wilsedes granary and the Emhof. So I thank you for accompanying First: St. Petersburg, where he worked my explanations of Alexander Maximov at the Military Medical Acad­ from st. Petersburg to us here in emy for some years. Wilsede. Second: In Berlin, the Charite Hospital, where he worked like his fa­ Michel Weidemann mous colleagues Arinkin and Botkin before. Maximov's world Third: And last station of his life was Etching 40 x 60 by Michel Weidemann the University of Chicago where he had to emigrate with heavy heart after october revolution. On the left side you see two blood pictures which have been drawn by Alexander Maximov. IX Scientific and private discussions on the Volga and around Uglich Xl XII Scientific and private discussions in and around "The Emhor' Photographs: R. Valz (Hamburg) XIII XIV Contents K. Munk: In Memoriam Clinical Aspects Dr. Mildred Scheel . XXI D. Pinkel: A. Ullrich and J. Schlessinger: Bone Marrow Transplantation Growth Factor Receptors: in Children with Acute Leukemia: Role in Normal Mitogenic Signalling A 1990 View. 3 and Oncogenesis ........... XXIII M. Eder, O. G. Ottmann, T. E. Hansen-Hagge, C. R. Bartram, V. T. Ivanov: In Memoriam S. Gillis, D. Hoelzer, and A. Ganser: Prof. Yuri Ovchinnikov . .. XXXIII Proliferation-Including Effects V. T. Ivanov and V. A. Nesmeyanov: of Recombinant Human Interleukin-7 Yuri Ovchinnikov ........... XXXV and Interleukin-3 in B-Lineage Acute Lymphoblastic Leukemia. .. 11 J. D. Rowley: Ovchinnikov Lecture K. Welte, C. Zeidler, A. Reiter, J. Rosler, Human Leukemia Genes: Search for the T. Pietsch, T. Hecht, and H. Riehm: Villains .............. XL Effects of Granulocyte Colony­ R. C. Gallo and L. S. Nerurkar: Stimulating Factor in Children with Ovchinnikov Lecture Severe Congenital Neutropenia . .. 16 Human Retroviruses: Linkage N. J. Simbirtseva: to Leukemia and AIDS. XLVII Interleukin-1 Production in Patients with Nonlymphocytic Leukemia Pastor Bode Lecture . .. LXX and Myelodysplastic Syndromes . .. 22 N. A. Mitchison: Pastor Bode Lecture: J. Boguslawska-Jaworska, J. Pisarek, Escape from the Red Queen . LXXIII A. Chybicka, B. Kazanowska, J. Armata, Frederick Stohlman Jr. Memorial W. Balwierz, H. Bubala, T. Jackowska, D. Michalewska, M. Ochocka, Lecture .................. LXXXI U. Radwanska, R. Rokicka Milewska, S. Broder: Clinical Research Using M. Rytlewska, S. Skomra, G. Sladkowska, 3' -Azido-2',3' -Dideoxythymidine (AZT) J. Wachowiak, M. Wieczorek, E. Zelenay, and Related Dideoxynucleosides D. SOilta-Jakimczuk, and A. Wozniak: in the Therapy of AIDS ..... LXXXIII The Results of Treatment of Acute Lymphoblastic Leukemia Relapses F. Grosveld, M. Antoniou, M. Berry, in the Polish Children's E. de Boer, N. Dillon, J. Ellis, P. Fraser, Leukemia/Lymphoma Study Group 28 D. Greaves, O. Hanscombe, J. Hurst, A. Petrakova and J. Stary: M. Lindenbaum, V. Mignotte, Long-Term Follow-up Study S. Philipsen, S. Pruzina, J. Strouboulis, in Childhood Acute Lymphoblastic D. Talbot, and D. Whyatt: The Human Leukemias . 32 f3-Globin Locus Control Region. .. CV T. Miyashita, S. Mizutani, M. Asada, List of Participants . CXIX J. Fujimoto, T. Inaba, and T. Furukawa: Monoclonal Blast Cell Proliferation Wilsede Scholarship Holders ... CXXVII in Transient Myeloproliferative Acknowledgements. .. CXXIX Disorder ................. 33 xv K. Palbczi, K. Natonek, E. Pbcsik, M. Waechter, E. Elstner, J. Maciejewski, B. Kottan, R. Mihalik, M. Benczur, H.-D. Volk, and R. lhle: J. Demter, and G. G. Petrlmyi: In Vitro Effect of GM-CSF and IFN-y The Comparison of the Expression on the Establishment of Stromal Layer of Activation Antigens on Peripheral and Hemopoiesis in Human Dexter Blood Mononuclear Cells Culture ...................
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