th 9 International Conference and Workshop on Biological Barriers – in vitro and in silico Tools for Drug Delivery and Nanosafety Research

2129 MarchFebruary – 1 - April9 March 2010 2012 University Saarbrücken,

Programme Chairs and Organisers: Prof. Dr. Claus-Michael Lehr, Prof. Dr. Ulrich F. Schäfer, Jun. Prof. Dr. Marc Schneider, Dr. Nicole Daum http://www.uni-saarland.de/biobarriers2012

Helmholtz Institute for Pharmaceutical Research Saarland Wednesday, 29 February 2012

Seminar 1: Skin Barrier Reaching the Immune System via the Skin: New Vaccines and Adjuvants - Challenges and Opportunities Microneedles Marc Prausnitz, University of Georgia, Atlanta, USA, TBC

Transdermal hyposensitation Thomas Kündig, University Hospital Zurich, Switzerland

Vaccine delivery and the role of new adjuvants Carlos Guzman, Helmholtz Centre for Infection Research, Braunschweig, Germany

Vaccine delivery in the skin Véronique Préat, University of Leuven, Belgium Emerging Needs and Models in Skin Delivery Models of the normal skin Bart de Wever, De Wever Consulting, Monaco

Models of the diseased skin Hans Christian Korting, LMU, Munich, Germany, TBC

Wound healing and infections Sheila MacNeil, University of Sheffield, UK Technologies to Overcome the Skin Barrier Laser ablation Yogeshvar Kalia, University of Geneva, Switzerland

Follicle targeting Jürgen Lademann, University Hospital Charité, , Germany

Patches Michael Horstmann, Tesa SE, , Germany

ROUND TABLE: Skin Lipids - What is state of the art? Lars Norlén, Karolinska University Hospital, Stockholm, Sweden

Joke Bouwstra, University of Leiden, The Netherlands

Phil Wertz, University of Iowa, USA

N.N.

biobarriers2012 Thursday, 1 March 2012

Seminar 1: Skin Barrier Nanomedicine for Dermal Applications Photodynamic therapy Alfred Fahr, Friedrich Schiller University Jena, Germany, TBC

SECosomes Barbara Geusens, Ghent University, Belgium

Silver nanoparticles Carsten Kneuer, Federal Institute for Risk Assessment (BfR), Berlin, Germany Analytic and Visualisation Tools Quantifying drug transport and effects by non-invasive imaging Michael S. Roberts, University of Queensland, Australia

Multiphoton imaging, CARS and Raman Karsten König, JenLab, Jena & , Germany

ESR Martina Meinke, University Hospital Charité, Berlin, Germany

Optical diagnoses of skin diseases Marica Ericson, University of Gothenburg, Sweden

Thursday, 1 March (afternoon) - Friday, 2 March 2012 Lab Course 1: Methods for the Skin Barrier ”Methods for the Skin Barrier” includes modules on Raman Microscopy, Franz-Diffusion-Cell, Tape-Stripping, in vivo and in vitro Multiphoton Imaging and CARS. The number of participants for Lab Course 1 is limited to 30 persons. Early registration recommended!

Saturday, 3 March 2012 Complementary Training Courses, e.g. Scientific Writing, IP Management, etc.

Sunday, 4 March 2012 Excursion to the Saar-Lor-Lux Region

biobarriers2012 Wednesday, 24 March –Monday, Sunday, 5 28March March 2012

Seminar 2: Nanomedicine and Nanotoxicology Nanomedicine and Nanotoxicology Nano-cell-interactions Wolfgang Parak, Philipps-Universität Marburg, Germany

Non-viral gene delivery systems Ernst Wagner, Philipps-Universität, Marburg, Germany

Signaling pathways to overcome cellular barriers Roland Brock, Nijmegen Centre for Molecular Life Sciences (NCMLS), Nijmegen, The Netherlands

Safety of Nanomaterials Nanotoxicology: challenges and pitfalls Vicki Stone, Heriot-Watt University Edinburgh, UK

Carbon nanotubes Kostas Kostarelos, London School of Pharmacy, UK

Computational approaches to nanotoxicology N.N.

Microbial and Immunological Barriers Bacterial adhesion and invasion strategies Petra Dersch, Helmholtz Centre for Infection Research, Braunschweig, Germany

Inflamed gut mucosa: a susceptible barrier Roel Schins, IUF - Leibniz Research Institute for Environmental , Düsseldorf, Germany

Microbial biofilms Susanne Häußler, Helmholtz Centre for Infection Research, Braunschweig, Germany

Nanotechnology and biofilms in dentistry Matthias Hannig, Saarland University Hospital, Homburg, Germany

Biodegradable nanocapsules for targeting the immune system Bruno de Geest, Ghent University, Belgium

biobarriers2012 Tuesday, 6 March 2012

BioBarriers meets Nano DDS

Invited Speakers

Mark Dewhirst, Duke University, Durham, USA

Aptameres and other new molecules asking for advanced delivery technologies Michael Famulok, , Germany

Hamid Ghandehari, University of Utah, Salt Lake City, USA

Alexander Kabanov, University of Nebraska, Omaha, USA

Complex polymeric nanocarriers as obtained by miniemulsion techniques Katharina Landfester, Max Planck Institute for Polymer Research, Mainz, Germany

Biocompatible Polymers Andreas Lendlein, HZG Center for Biomaterial Development, Teltow, Germany

Julia Ljubimova, Cedars-Sinai Medical Center, Los Angeles, USA

Tamara Minko, Rutgers University, New Brunswick, USA

Vincent M. Rotello, University of Massachusetts, Amherst , USA

High throughput synthesis and screening of pharmaceutical polymers Ulrich Schubert, Friedrich Schiller University Jena, Germany

Oral Presentations to be selected from submitted abstracts of participants.

biobarriers2012 Wednesday, 7 March 2012

Seminar 2: Nanomedicine and Nanotoxicology Advanced Cell and Tissue Based in vitro Models as Alternatives to Animal Testing

Ethical aspects of animal experiments N.N.

Immortalization strategies for mammalian cells Dagmar Wirth, Helmholtz Centre for Infection Research, Braunschweig, Germany

Macrophage models Alexandra K. Kiemer, Saarland University, Saarbrücken, Germany

Complex models of the air blood barrier Sabine Fuchs, Johannes Gutenberg University, Mainz, Germany

3D cultures in the rotating wall vessel Cheryl Nickerson, Arizona State University, USA

M-cell co-cultures Hans Bouwmeester, RIKILT – Institute of Food Safety, Wageningen, The Netherlands, TBC

Modeling the placenta barrier Peter Wick, Empa, St. Gallen, Switzerland

Integrated “quasi-vivo“ models Arti Ahluwalia, University of Pisa, Italy

Thursday, 8 March (afternoon) - Friday, 9 March 2012 Lab Course 2: Pharmaceutical Nanomaterials "Pharmaceutical Nanomaterials" includes modules on the preparation and characterization of nanoparticles and their interaction with biological barriers including modern visualization tools, e.g. AFM, SEM. The number of participants for Lab Course 2 is limited to 40 persons. Early registration recommended!

biobarriers2012 Further information Registration and Booking Tuesday, 6 March 2012 Wednesday, 7 March 2012 (name)

Seminar 2: Nanomedicine and Nanotoxicology Fax ++49(681) 302-4270 (affiliation) Advanced Cell and Tissue Based in vitro Models as Alternatives to Animal Testing Please contact the KWT conference office for further information, registration and booking. Ethical aspects of animal experiments th 9th International Conference and Workshop on Biological Barriers Hanno Würbel, Veterinary Public Health Institut, Bern, Switzerland, International Conference and Workshop on BioBarriers meets Nano DDS TBC 9 KWT – Conference Office Biological Barriers – T: ++49 – 681 – 302 – 2656 Invited Speakers Immortalization strategies for mammalian cells F: ++49 – 681 – 302 – 4270 Dagmar Wirth, Helmholtz Centre for Infection Research, Tools [email protected] Braunschweig, Germany in vitro and in silico www.uni-saarland.de/biobarriers2012 Mark Dewhirst, Duke University, Durham, USA Macrophage models for Drug Delivery and Subscribe to our mailing list to receive the latest news on BB12 ([email protected]). Aptameres and other new molecules asking for advanced Alexandra K. Kiemer, Saarland University, delivery technologies Saarbrücken, Germany Nanosafety Research Michael Famulok, University of Bonn, Germany Complex models of the air blood barrier Hamid Ghandehari, University of Utah, Salt Lake City, USA Sabine Fuchs, Johannes Gutenberg University, For the course booking, please mark with a cross the seminars and labcourses that you want to attend. Please also register for the optional events if Mainz, Germany you are interested to join. We can not guarantee that you can participate if you have not registered for these events in advance. Alexander Kabanov, University of Nebraska, Omaha, USA 3D cultures in the rotating wall vessel Students/ Academic Industry Complex polymeric nanocarriers as obtained Cheryl Nickerson, Arizona State University, USA, TBC by miniemulsion techniques early regular early regular Katharina Landfester, Max Planck Institute for Polymer Research, M-cell co-cultures Mainz, Germany Hans Bouwmeester, RIKILT – Institute of Food Safety, Wageningen, 2129 MarchFebruary – 1 - April9 March 2010 2012 The Netherlands, TBC Seminar 1 – Skin Barrier 29 Feb – 1 Mar 250 € 350 € 400 € 500 € Biocompatible Polymers Saarland University Andreas Lendlein, HZG Center for Biomaterial Development, Modeling the placenta barrier Saarbrücken, Germany Seminar 1 and LabCourse 1 1 – 2 Mar 550 € 750 € 900 € 1100 € Teltow, Germany Peter Wick, Empa, St. Gallen, Switzerland Seminar 2 - Nanomedicine/ -toxicology 5 – 7 Mar 300 € 400 € 500 € 600 € Julia Ljubimova, Cedars-Sinai Medical Center, Los Angeles, USA Integrated “quasi-vivo“ models Seminar 2 and LabCourse 2 7 – 9 Mar 600 € 800 € 1000 € 1200 € Arti Ahluwalia, University of Pisa, Italy All-in price 900 € 1200 € 1500 € 1900 € Tamara Minko, Rutgers University, New Brunswick, USA

Vincent M. Rotello, University of Massachusetts, Amherst , USA Thursday, 8 March (afternoon) - Friday, 9 March 2012 Free optional bookings: Lab Course 2: Pharmaceutical Nanomaterials High throughput synthesis and screening of Management Training Course 3 Mar free for all participants pharmaceutical polymers "Pharmaceutical Nanomaterials" includes modules on the Excursion 4 Mar free for all participants Ulrich Schubert, Friedrich Schiller University Jena, Germany preparation and characterization of nanoparticles and their interaction with biological barriers including modern visualization Conference Dinner 6 Mar free for all participants tools, e.g. AFM, SEM. Programme Chairs and Organisers: The number of participants for Lab Course 2 is limited to 40 persons. Prof. Dr. Claus-Michael Lehr, Prof. Dr. Ulrich F. Schäfer, Oral Presentations Early registration recommended! Jun. Prof. Dr. Marc Schneider, Dr. Nicole Daum to be selected from submitted abstracts of participants. Early registration fees apply when registration is submitted and fee paid before 15 December 2011. All fees include: A conference dinner, various receptions, basic lunch caterings, coffee and public transportation within Saarbrücken. http://www.uni-saarland.de/biobarriers2012

Helmholtz Institute for Pharmaceutical Research Saarland biobarriers2012 biobarriers2012 biobarriers2012 biobarriers2012 Wednesday, 24 March Registration Form Fax ++49(681)302-4270 Wednesday, 29 February 2012 Thursday, 1 March 2012 –Monday, Sunday, 5 28March March 2012

Abstracts + Posters Personal Details Seminar 1: Skin Barrier Seminar 1: Skin Barrier Seminar 2: Nanomedicine and Nanotoxicology Posters of participants will be on display during the entire workshop. Reaching the Immune System via the Skin: Nanomedicine for Dermal Applications Nanomedicine and Nanotoxicology Participants who wish to give a poster presentation must submit a New Vaccines and Adjuvants - Challenges and Photodynamic therapy Nano-cell-interactions 1-page (A4) abstract. Opportunities Title Alfred Fahr, Friedrich Schiller University Jena, Germany, TBC Wolfgang Parak, Philipps-Universität Marburg, Germany The poster may have a maximum size of 85 cm (horizontal) and Microneedles 120 cm (vertical). Marc Prausnitz, University of Georgia, Atlanta, USA, TBC SECosomes Non-viral gene delivery systems Name Barbara Geusens, Ghent University, Belgium Ernst Wagner, Philipps-Universität, Marburg, Germany Transdermal hyposensitation I will submit abstract and poster Thomas Kündig, University Hospital Zurich, Switzerland Silver nanoparticles Signaling pathways to overcome cellular barriers First Name Carsten Kneuer, Federal Institute for Risk Assessment (BfR), Roland Brock, Nijmegen Centre for Molecular Life Sciences I will NOT submit abstract and poster Vaccine delivery and the role of new adjuvants Berlin, Germany, TBC (NCMLS), Nijmegen, The Netherlands, TBC Carlos Guzman, Helmholtz Centre for Infection Research, Deadline for abstract submission: 1 February 2012. Affiliation Braunschweig, Germany Analytic and Visualisation Tools Accomodation Safety of Nanomaterials Quantifying drug transport and effects by non-invasive imaging Vaccine delivery in the skin I am interested in Michael S. Roberts, University of Queensland, Australia Nanotoxicology: challenges and pitfalls Address Véronique Préat, University of Leuven, Belgium Vicki Stone, Heriot-Watt University Edinburgh, UK student housing Emerging Needs and Models in Skin Delivery Multiphoton imaging, CARS and Raman hotel list Karsten König, JenLab, Jena & Saarland University, Germany Carbon nanotubes Phone/Fax Models of the normal skin Kostas Kostarelos, London School of Pharmacy, UK Bart de Wever, De Wever Consulting, Monaco ESR Assistance Martina Meinke, University Hospital Charité, Berlin, Germany Computational approaches to nanotoxicology e-mail Models of the diseased skin N.N. I am handicapped and need assistance. Hans Christian Korting, LMU, Munich, Germany, TBC Optical diagnoses of skin diseases Payment Information: Marica Ericson, University of Gothenburg, Sweden Wound healing and infections Microbial and Immunological Barriers Universität des Saarlandes Sheila MacNeil, University of Sheffield, UK Thursday, 1 March (afternoon) - Friday, 2 March 2012 Bacterial adhesion and invasion strategies Bank1Saar Technologies to Overcome the Skin Barrier Lab Course 1: Methods for the Skin Barrier Petra Dersch, Helmholtz Centre for Infection Research, Sponsoring/ Industry Exhibition: BLZ 591.900.00 Braunschweig, Germany ”Methods for the Skin Barrier” includes modules on Raman Microscopy, Companies interested in sponsoring this event, as well as in Laser ablation Account-No 1011-69006 Franz-Diffusion-Cell, Tape-Stripping, in vivo and in vitro Multiphoton displaying their products during the conference, are cordially invited Yogeshvar Kalia, University of Geneva, Switzerland Inflamed gut mucosa: a susceptible barrier Imaging and CARS. to contact the organizers. Roel Schins, IUF - Leibniz Research Institute for Environmental IBAN: DE87.5919.0000.0101.1690.06 The number of participants for Lab Course 1 is limited to 30 persons. Follicle targeting Medicine, Düsseldorf, Germany Early registration recommended! BIC: SABADE5S Jürgen Lademann, University Hospital Charité, Berlin, Germany Microbial biofilms For credit card payment (MasterCard and VISA accepted) please see Saturday, 3 March 2012 Patches Susanne Häußler, Helmholtz Centre for Infection Research, the form on the website. Frankfurt a. Main Michael Horstmann, Tesa SE, Hamburg, Germany Complementary Training Courses, e.g. Scientific Braunschweig, Germany Writing, IP Management, etc. Luxembourg Nanotechnology and biofilms in dentistry ROUND TABLE: Matthias Hannig, Saarland University Hospital, Homburg, Germany Sunday, 4 March 2012 Heidelberg Skin Lipids - What is state of the art? Excursion to the Saar-Lor-Lux Region Understanding interactions of nanomaterials Saarbrücken Lars Norlén, Karolinska University Hospital, Stockholm, Sweden with the immune system Bengt Fadeel, Karolinska Institute, Stockholm, Sweden, TBC Paris Strasbourg Joke Bouwstra, University of Leiden, The Netherlands Biodegradable nanocapsules for targeting the immune system Phil Wertz, University of Iowa, USA Bruno de Geest, Ghent University, Belgium N.N.

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