QUALIFICATIONS OF EMORY UNIVERSITY

GENERAL EXPERIENCE & ORGANIZATIONAL STRUCTURE

Emory University is well qualified to undertake this research.

With roots tracing back to 1836, Emory today is one of the most highly regarded research universities in the world and ranks in the top 20 best colleges by US News & World Report. Emory includes nine colleges and schools: College of Arts and Sciences, , Laney Graduate School, School of Law, School of Medicine, Nell Hodgson Woodruff School of Nursing, Oxford College, Rollins School of Public Health, and Candler School of Theology. Emory is also home to multiple research centers, the largest being the Robert W. Woodruff Health Sciences Center (WHSC) which brings together the School of Medicine, Nell Hodgson Woodruff School of Nursing, Rollins School of Public Health, the Yerkes National Primate Research Center, the Winship Cancer Institute, Emory Global Health Institute, and (EHC) to facilitate biomedical science. A major provider of patient care in and the region, WHSC is national recognized for clinical, educational and research programs, and its hospitals and professional schools are ranked among the top in the nation. Emory also has a rich history of research and scholarship in the humanities, law, and business. For example, the University supports the , the Emory Center for Ethics, Halle Institute for Global Research, Emory Institute for Developing Nations, James Weldon Johnson Institute, and the Center for the Study of Law and Religion, to name but a few. Emory’s operating budget for 2018-2019 is $5.6 billion: $2.1 billion on the University side and $3.5 billion for Emory Healthcare (EHC). The campus community is made up of 8,079 undergraduate and 7,372 graduate and professional students, and 14,349 University faculty and staff.

Major hospital affiliates for patient care, teaching and research include the following: , Atlanta Veterans Affairs Medical Center, and Wesley Woods Geriatric Hospital at Emory University. Emory’s hospital system represents a wide variety of medical practice types, including a university referral hospital, a community-based university hospital, a veteran’s hospital, and a reference laboratory practice. Each site contributes its own unique environment and provides for the broadest clinical exposure and opportunity for both faculty and residents.

Emory University School of Medicine conducts an extensive program of teaching, research, and service. The school has over 462 medical students, including MD/MPH students, and shares a number of MD/PhD students with Emory’s graduate school. The medical school also trains more than 1,000 residents and fellows and has 364 students in five top-ranking allied health programs. Faculty in basic science and clinical department’s totaled 1,929. The school is known for its research programs in cancer, neuroscience, vaccine development, transplantation biology, cardiology, biomedical engineering, and genetics. Faculty clinicians in Emory’s own or affiliated teaching hospitals are responsible for more than 3.3 million patient visits annually.

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Emory University

The Emory Vaccine Center, founded in 1997 and directed by Dr. Rafi Ahmed and Dr. Walter Orenstein, provides a 76,000-square- foot vaccine research building at the Yerkes National Primate Research Center. The Emory Vaccine Center has a number of shared facilities that all PIs have immediate access to. These include BSL-3 facilities located on all three floors with individual suites equipped with biosafety tissue culture hoods, centrifuges, freezers, and refrigerators plus autoclave and cryo-freezers. The Vaccine Center has specialized equipment available for use by all of its PIs including FPLC for protein purification and HPLC for peptide analysis and high-pressure size exclusion chromatography. There is a Bellco bioreactor for antibody production. Also available is a Millipore Tangential Flow System for rapid concentration of proteins and tissue supernatants by ultrafiltration. In addition, there are dark rooms, cold rooms, walk-in freezers, ice machines, dry ice, liquid scintillation counters and gamma counters, ultra centrifuges and other assorted equipment. Conference rooms are available on each floor for lab meetings or seminars and two large seminar-lecture rooms are available on the first floor. Within the Primate Center there are support personnel to assist with administration, purchasing, travel, budget and IT matters. Also available are building are building maintenance, metal and woodworking shops, glassware cleaning and autoclaving services, DNA sequencing, oligo synthesis, peptide synthesis, peptide mass spectrometers and peptide oligonucleotide synthesis facility.

Yerkes National Primate Research Center, one of eight national primate research centers funded by the National Institutes of Health, is a multidisciplinary research institute recognized as a leader in biomedical and behavioral studies with non-human primates. Yerkes scientists are on the forefront of healthcare innovations, including developing vaccines for AIDS and malaria, and treatments for cocaine addiction and Parkinson’s disease. They are also leading programs aimed at understanding the aging process, pioneering organ transplant procedure, determining the behavioral effects of hormone replacement therapy and shedding light on human behavioral evolution. The Yerkes National Primate Research Center is the only US primate facility to have on-site imaging capabilities, which are critical to study neurological development and disease progression and evaluating new therapies. The Yerkes National Primate Research Center consists of two facilities: The Yerkes Main station, located on 25 acres of the Emory campus in Atlanta, contains most of the center’s biomedical research laboratories; The Yerkes Field Station, on 117 acres of wooded land near Lawrenceville, 30 miles north of Atlanta, specializes in behavioral studies of primate social groups. Seven species of primates are represented in the center’s colony totaling some 3,600 animals. They include rhesus, sooty mangabeys , capuchins, squirrel monkeys , cynomolgus monkeys, and chimpanzees. Yerkes scientist collaborate in join research and educational endeavor with many departments of the University and School of Medicine, as well as other institutions in this country and abroad.

Rollins School of Public Health has more than 850 students pursuing master’s degrees and more than 100 PhD students in behavioral sciences and health education, biostatistics,

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Emory University epidemiology, health policy and management, and nutrition. Research funding received in 2016 totaled approximately $94.8 million. The school offers dual degrees with medicine, nursing, business, and law as well the distance-based career MPH degree, which allows working professionals to pursue degrees without interrupting employment. The school has 180 full-time and more than 200 adjunct faculty in six academic departments and more than 3,750 alumni. Through its collaborations with the CDC, The Carter Center, the American Cancer Society, CARE, the Arthritis Foundation, and state and local public health agencies and in its role as a center for international health research and training, the school helps make Atlanta a worldwide destination for public health.

Nell Hodgson Woodruff School of Nursing has 208 baccalaureate students, 162 full- and part time master’s students, and 14 doctoral students. The doctoral program focuses on clinical research with an emphasis on health policy, health outcomes, and ethics. Nationally, the school ranks 19th among more than 600 nursing schools for research funding from the National Institutes of Health and 26th overall by US News & World Report. The school has 38 full-tie faculty, and students also learn from experts at 81 clinical sites.

Other multidisciplinary centers and institutes include the Emory Transplant Center, Emory/ Tech Predictive Health Institute, Global Health Institute, Heart and Vascular Center, Center for Comprehensive Informatics, and Brain Health Center.

In addition to its vast academic mission, Emory Healthcare (EHC) is the largest healthcare system in the state consisting of seven major hospitals:

● Emory University Hospital,

● Emory University Hospital Midtown

● Emory University Orthopedics & Spine Hospital

● Emory Saint Joseph’s Hospital

● Emory Johns Creek

●Emory Rehabilitation Hospital

● Emory University Hospital Smyrna

Emory Healthcare Network (EHN), is also the most comprehensive clinically integrated network in Georgia, with 22,605 employees, seven hospitals, and 200 provider locations across the state. EHN physicians practice in more than 70 specialties, including more than 220 who practice primary care. In fiscal year 2018, EHC had $3.57 billion in net revenue and provided $98 million in charity care. Annual hospital admissions total 75,492, and outpatient

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Emory University service visits total 4.7 million. In fiscal year 2018, EHC clinicians saw 617,094 individual patients.

EHN also includes nearly 60 Minute Clinics and Peachtree Immediate Care and SmartCare urgent care locations throughout metro Atlanta.

EHC has 2,691 hospital beds. EHC includes a joint venture with Select Medical for rehabilitation medicine and is also affiliated with Stratus Healthcare, a nonprofit alliance of care providers located primarily in Central and South Georgia. EHC physicians include faculty in Emory School of Medicine, which has long-standing relationships in patient care, teaching, and research with Grady Memorial Hospital, the Atlanta Veterans Affairs Medical Center, and Children’s Healthcare of Atlanta The Emory Clinic is the largest, most comprehensive group practice in Georgia with more than 1,400 Emory faculty physicians and locations throughout the city and state. The Emory Specialty Associates is an outreach physician practice organization with 34 locations in 11 Georgia counties. Emory also includes the Emory Wesley Woods Campus, which includes a psychiatric annex of Emory University Hospital as well as skilled nursing care and residential retirement facilities

Campus Research Facilities

Center for Rehabilitation Medicine Building This building houses the offices and research laboratories for the Department of Rehabilitation Medicine.

O. Wayne Rollins Research Building The Rollins Research Center is a 256,250 square foot multidisciplinary research facility that houses departments of Biochemistry, Microbiology/Immunology, Pharmacology and others. It is connected to research facilities and library in the Dental Building, the Rollins School of Public Health Building and to the Whitehead Research Building.

Whitehead Research Building This 325,020 square foot building, completed in 2001, is the largest on the Emory campus and provides research facilities for departments including Cell Biology, Physiology, Pathology, Genetics and an interdisciplinary Neuroscience program.

Robert W. Woodruff Health Science Center Library The Health Sciences Center Library, one of five specialized libraries on the Emory campus, is located within the Dental Building. The library houses more than 250,000 volumes and 2,900

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Emory University current periodicals, on-line journals and bibliographic databases, a computer laboratory, and audiovisual material and facilities. Clinical branch libraries are maintained in Emory University Hospital and in the Glenn Memorial Building opposite Grady Memorial Hospital. The House Staff/Medical Student Learning Center, located on the 16th floor of Grady Hospital, provides 24- hour access to health sciences literature. The library is open seven days a week. Services include circulation, clinical librarianship, document delivery reference consultation, curriculum support services, and classes in the use of information resources. The library is a Resources Library of the National Network of Libraries of Medicine.

Organizational Experience Related to the RFP Under the umbrella of the Emory University Organization, the various clinical and basic science departments are encouraged to participate in a multidisciplinary approach to medical research. In addition to the organizational framework, the physical proximity of these groups on the same campus aids in fostering such excellence in patient care and services as a Southeast referral facility. At the same time, research programs in the basic sciences are growing and have achieved recognition through increased extramural funding.

MISSION & PURPOSE – School of Medicine

Emory University’s School of Medicine is committed to recruiting and developing a diverse group of students and innovative leaders in biomedical science, public health, medical education and clinical care. The school integrates basic, translational and clinical research to further our ability to deliver quality health care, predict illness and provide treatment, and to promote the health of our patients and community. The School’s mission encompasses several goals: (1) provide educational programs for students and train health care professionals; (2) develop clinicians and investigators who will provide the highest quality of compassionate care and serve the needs of their community and world consistent with the best traditions of our profession; (3) conduct innovative and collaborative research, and integrating this knowledge into the practice of medicine; (4) advance early detection, treatment and prevention of disease; and, (5) ensure we follow the highest ethical and professional standards in all of our endeavors.

RESEARCH PERFORMANCE HISTORY Emory has established a history of excellent performance on numerous Federal contracts and grants. Emory is one of the nation's leading research institutions, building on an uncommon combination of resources and global partnerships. Emory supports researchers in the advancement of public scholarship, accelerating the application of discoveries, and communicating their significance to general audiences. In fiscal year 2018, Emory received $734 million in total research funding awards. Of the overall total, $440.8 million came from federal

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Emory University research funding awards, led by the National Institutes of Health with $359.2 million. Emory researchers submitted 4,410 proposals to sponsors totaling $1.197 billion in 2018.

The bulk of Emory’s research activity is conducted by scientists in the schools of medicine, public health, and nursing, the Winship Cancer Institute, and Yerkes National Primate Research Center. In fiscal year 2017 these entities combined received more than $584.8 million in sponsored research funding.

Emory has a number of research centers funded by the National Institutes of Health including the Emory Winship Cancer Institute, a National Cancer Institute-designated center; the Emory Vaccine Center, one of the world's largest vaccine research centers; the Emory Center for AIDS Research; the Georgia Clinical & Translational Science Alliance; the Influenza Pathogenesis & Immunology Research Center; the Alzheimer's Disease Research Center; and the Chemical and Biology Discovery Center.

Emory is a partner in two state collaborations of academia, business, and government: the Georgia Research Alliance and the Georgia Cancer Coalition. Other key research partners include the nearby Atlanta VA Healthcare System, Centers for Disease Control and Prevention, Children's Healthcare of Atlanta, the Georgia Institute of Technology, Morehouse School of Medicine, and the University of Georgia.

Emory is a national leader in technology transfer, with more than 1,600 active technologies, over 1,200 pending patent applications, approximately 350 active licenses, and more than 90 start-ups. Over the past two decades, Emory has received more than $806 million in licensing revenues from drugs, diagnostics, devices, and consumer products.

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