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DHRS2 polyclonal antibody

Catalog: BS8526 Host: Rabbit Reactivity: Human,Mouse,Rat

BackGround: IF: 1:50~1:200 DHRS2 (dehydrogenase/reductase (SDR family) member Storage&Stability: 2), also known as SDR25C1 or HEP27, is a 258 amino Store at 4°C short term. Aliquot and store at -20°C long acid protein that localizes to the nucleus and belongs to term. Avoid freeze-thaw cycles. the short-chain dehydrogenase/reductase (SDR) family. Specificity: Functioning as an NADPH-dependent dicarbonyl reduc- DHRS2 polyclonal antibody detects endogenous levels of tase, DHRS2 is thought to inhibit cell replication by ei- DHRS2 protein. ther converting cortisone in cortisol, or by catalyzing the DATA: oxidation of androgen and estrogen. The encoding DHRS2 maps to human 14, which houses over 700 and comprises nearly 3.5% of the . encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes asso- ciated with the development of Alzheimer's disease (AD).

The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder Western blot analysis of extracts of various cell lines, using DHRS2 an- α1-antitrypsin deficiency, which is characterized by se- tibody. vere lung complications and liver dysfunction. Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Molecular Weight: ~ 33 kDa Swiss-Prot: Q13268 Immunofluorescence analysis of HeLa cell using DHRS2 antibody. Purification&Purity: Blue: DAPI for nuclear staining. The antibody was affinity-purified from rabbit antiserum Note: by affinity-chromatography using epitope-specific im- For research use only, not for use in diagnostic procedure. munogen and the purity is > 95% (by SDS-PAGE). Applications: WB: 1:500~1:2000 IHC: 1:50~1:200

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