TOP2A Antibody Cat. No.: 13-266

TOP2A Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human, Mouse

IMMUNOGEN: A synthetic peptide of human TOP2A

TESTED APPLICATIONS: IF, IHC, WB

WB: ,1:500 - 1:2000

APPLICATIONS: IHC: ,1:50 - 1:200

IF: ,1:20 - 1:50

POSITIVE CONTROL: 1) Jurkat

2) K-562

3) A375

4) SKOV3

5) NIH/3T3

PREDICTED MOLECULAR Observed: 200kDa WEIGHT:

Properties

September 27, 2021 1 https://www.prosci-inc.com/top2a-antibody-13-266.html PURIFICATION: Affinity purification

CLONALITY: Polyclonal

ISOTYPE: IgG

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: PBS with 0.02% sodium azide, pH7.3.

STORAGE CONDITIONS: Store at 4˚C. Avoid freeze / thaw cycles.

Additional Info

OFFICIAL SYMBOL: TOP2A

ALTERNATE NAMES: TOP2A, TOP2, TP2A

GENE ID: 7153

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

This encodes a DNA , an that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass BACKGROUND: through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a event. The gene encoding this form, alpha, is localized to and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

ANTIBODIES FOR RESEARCH USE ONLY.

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September 27, 2021 2 https://www.prosci-inc.com/top2a-antibody-13-266.html