alzheimer’s Disease A Century of Scientific and Clinical Research
1963 1987 1988 Identification of PairedHelical Cloning of the Amyloid-Beta Filaments and Structural 1980-1996 Protein Precursor Protein Dissection of PHF 1993 Characterization of AD Identification of Lewy 1985-1991 Dmitry Goldgaber Claude M. WischIk Synaptic Abnormalities 1995 1995-1996 1998-2003 Michael Kidd 1975-1980 Body Disease 1982 Diagnosis 1986 Nicholas Robakis R. Anthony Crowther 1991 in AD Presenilins Transgenic Mouse Model Amyloid Oligomers Robert D. Terry Aluminum Kenji Kosaka Neuronal Loss Zaven Khachaturian Tacrine – Konrad Beyreuther Aaron Klug Braak Staging Eliezer Masliah 1993 Peter St. George-Hyslop Karen H. Ashe Caleb E. Finch Henryk Wisniewski Donald Crapper Ian G. McKeith Robert D. Terry Suzanne Mirra the First AD Therapeutic Rudolph E. Tanzi Michel Goedert Eva Braak Robert D. Terry Apolipoprotein E Rudolph E. Tanzi Dora Games William L. Klein Asao Hirano Daniel P. Perl Catherine Bergeron Melvyn J. Ball John C. Morris William Summers Peter St. George-Hyslop Yasuo Ihara Heiko Braak Stephen W. Scheff Allen D. Roses Christine Van Broeckhoven Dale Schenk Charles G. Glabe 1906 2006 1968 1976-1981 1981 1984-1985 1985 1986 1990-1991 1992 1994 1998 1999 Clinical Definition of AD Cholinergic Hypothesis PHF Insolubility Sequencing Amyloid- Inflammation Identification of Tau in Mutations in AD and Amyloid Cascade Oxidative Stress Tauopathy Immunotherapy for AD as an Age-Related Dementia Peter Davies Khalid Iqbal Beta Patrick McGeer Neurofibrillary Tangles Related Conditions Hypothesis William R. Markesbery Bernardino Ghetti Beka Solomon Gary Blessed Peter J. Whitehouse Dennis J. Selkoe Colin L. Masters Edith McGeer Jesus Avila Christine Van Broeckhoven Gerry Higgins M. Flint Beal Michel Goedert Dale Schenk Martin Roth David M. Bowen Yasuo Ihara George Glenner Joseph Rogers George Perry Blas Frangione John Hardy Mark A. Smith Gerard D. Schellenberg Bernard Tomlinson Raymond T. Bartus Konrad Beyreuther Jean-Pierre Brion Alison Goate George Perry Maria Grazia Spillantini Robert Katzmann Kenneth S. Kosik John Hardy Khalid Iqbal Inge Grunde-Iqbal Dennis J. Selkoe