MRC FOUR-YEAR PHD PROGRAMME IN HUMAN GENETICS, GENOMICS AND DISEASE Chromosome Segregation in the Mouse Protein assembly in human genetic disease Germline and cancer Ian Adams Joe Marsh Decoding the precise spatial and temporal The Role of DNA methylation in cellular dynamics of PAX6 cis-regulatory landscape transitions Wendy Bickmore Richard R Meehan A dedicated Nonsense-mediated (NMD) Decoding mammalian cilial diversity in the pathway in the endoplasmic reticulum brain (ER-NMD) Pleasantine Mill Javier F. Caceres Dynamics of transcription factor Functional genomic interrogation of concentration, -binding kinetics trans-eQTL regulatory hubs and the role and cell-to-cell variability during zebrafish of functional epistasis in the development Zygotic Activation of large bowel cancer Dimitrios Papadopoulos Malcolm Dunlop ALDH enzymes in melanoma stem cell Functional Analysis of Eye Field lineages Transcription Factors Using In Vitro Liz Patton Differentiation of Embryonic Stem Cells Predicting disease risk from the genetic David FitzPatrick determinants of RNA velocity Understanding mitotic chromosome Chris Ponting unpackaging Using synthetic to understand how Nick Gilbert the epigenome is programmed in cancer Chromatin Architecture, Enhancer Structure Duncan Sproul and Congenital Abnormalities Identifying rare large-effect variants in Bob Hill isolate populations DNA outside the nucleus in Quantitative Trait Loci (QTL) autoinflammation and carcinogenesis Chromatin manipulation to enhance genome Andrew Jackson editing outcomes Next generation RNA genotype-phenotype Andrew Wood mapping Grzegorz Kudla Applications are invited from outstanding candidates to join an innovative and exciting MRC funded 4-year multidisciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), the . 8 studentships are available to start in September 2018 with a stipend of £17,500 p/a. Application closing date Friday 12th January 2018.

For further information and details of how to apply please visit: www.ed.ac.uk/mrc-human-genetics-unit/study-with-us

MRC Human Genetics www.ed.ac.uk/mrc-human-genetics-unit Our DNA...Our Lives