ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005

Volume 26, Number 3B, May-June 2006

Contents Clinical Studies

Glucuronidation of SN-38 and NU/ICRF 505 in Human Colon Cancer and Adjacent Normal Colon. J. CUMMINGS, B.T. ETHELL, L. JARDINE, B. BURCHELL (Edinburgh; Dundee, UK)...... 2189

In Vitro Cytotoxic Effect of and Pilot Phase II Study in Hormone-refractory Prostate Cancer. P. MOUGENOT, F. BRESSOLLE, S. CULINE, I. SOLASSOL, S. POUJOL, F. PINGUET (Montpellier, France) ...... 2197

Molecular and Virological Studies on a Rare Case of Biliary Papillomatosis. P. GUNVÉN, G. AUER, U. GERDES, H. M. DAHLSTRAND, I. LEWENSOHN-FUCHS, T. DALIANIS (Stockholm, Sweden)..... 2205

Cell Cycle Control by p21, p27 and p53 in Merkel Cell Carcinoma. V. KOLJONEN, E. TUKIAINEN, C. HAGLUND, T. BÖHLING (Helsinki, Finland) ...... 2209

Lung Cancer Arising in Association with Middle Lobe Syndrome. A. YAMASAKI, K. TOMITA, H. CHIKUMI, T. TATSUKAWA, Y. SHIGEOKA, M. NAKAMOTO, K. HASHIMOTO, Y. HASEGAWA, E. SHIMIZU (Tottori, Japan) ...... 2213

Malignant Hidradenoma: A Report of Two Cases and Review of the Literature. I.E. LIAPAKIS, D.P. KORKOLIS, A. KOUTSOUMBI, A. FIDA, G. KOKKALIS, P.P. VASSILOPOULOS (Athens, Greece)...... 2217

Reduction Therapy of Alanine Aminotransferase Levels Prevent HCC Development in Patients with HCV- associated Cirrhosis. Y. RINO, K. TARAO, S. MORINAGA, S. OHKAWA, K. MIYAKAWA, S. HIROKAWA, T. MASAKI, N. TARAO, N. YUKAWA, H. SAEKI, Y. TAKANASHI, T. IMADA (Yokohama, Japan) ...... 2221

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Association Between Single Nucleotide Polymorphisms of Drug Resistance-associated Genes and Response to in Advanced Ovarian Cancer. H. OBATA, T. YAHATA, J. QUAN, M. SEKINE, K. TANAKA (Niigata, Japan)...... 2227

Effect of Chemotherapy on Somatostatin Receptor Detection with Octreotide Scintigraphy in Hormone- refractory Prostate Cancer Patients. M. MENCOBONI, S. TREDICI, L. REBELLA, M. BERGAGLIO, V. GALBUSERA, A. MANZARA, F. CLAUDIANI, B. MALCANGI, M. VARALDO (Genoa, Italy)...... 2233

Treatment of Advanced Gastric Cancer by Chemotherapy Combined with Autologous Cytokine-induced Killer Cells. J. JIANG, N. XU, C. WU, H. DENG, M. LU, M. LI, B. XU, J. WU, R. WANG, J. XU, P. NILSSON-EHLE (Changzhou, China; Lund, Sweden) ...... 2237

Expression of FHIT in Esophageal Epithelium and Carcinoma: Reference to Drinking, Smoking and Multicentric Carcinogenesis. M. MORITA, T. OYAMA, S. NAKATA, K. ONO, M. SUGAYA, H. URAMOTO, T. YOSHIMATSU, T. HANAGIRI, K. SUGIO, K. YASUMOTO (Kitakyushu, Japan).... 2243

Capecitabine-induced Hypertriglyceridemia: A Report of Two Cases. A.K. KOUTRAS, I.G. HABEOS, A.G. VAGENAKIS, H.P. KALOFONOS (Patras, Greece) ...... 2249

MRI Characteristics of Parosteal Lipomas Associated with the HMGA2-LPP Fusion Gene. T. KUBO, Y. MATSUI, T. GOTO, K. YUKATA, K. ENDO, R. SATO, T. TSUTSUI, N. YASUI (Tokushima, Japan) ... 2253

Topotecan in the Treatment of Brain Metastases. A Phase II Study of GOIM (Gruppo Oncologico dell’Italia Meridionale). V. LORUSSO, D. GALETTA, F. GIOTTA, A. RINALDI, S. ROMITO, C. BRUNETTI, N. SILVESTRIS, G. COLUCCI (Bari; Castellaneta; Campobasso; Manduria; Latina, Italy).... 2259

Phase I Study of S-1 and Nedaplatin for Patients with Recurrence of Head and Neck Cancer. T. KODAIRA, N. FUWA, H. TACHIBANA, S. HIDANO (Nagoya, Aichi, Japan) ...... 2265

Is Pancreatic Resection Justified for Metastasisn of Papillary Thyroid Cancer? A. MEYER, M. BEHREND (Deggendorf, Germany) ...... 2269

Cell Proliferation at the Leading Invasive Front of Colonic Carcinomas. Preliminary Observations. C.A. RUBIO (Stockholm, Sweden)...... 2275

Dermatological Toxicity of . A.K. CONLIN, L. VAHDAT (New York, NY, USA) ...... 2279

Expression of MAGE-A Cancer/Testis Antigens in Esophageal Squamous Cell Carcinomas. J. HAIER, M. OWZCARECK, U. GULLER, G.C. SPAGNOLI, H. BÜRGER, N. SENNINGER, TH. KOCHER (Münster, Germany; Basel; Baden, Switzerland) ...... 2281

Outcome of Palliative Care Regimens in Patients with Advanced Oesophageal Cancer Detected During Explorative Surgery. B.B. PULTRUM, H.L. VAN WESTREENEN, N.H. MULDER, H.M. VAN DULLEMEN, J.TH.M. PLUKKER (Groningen, The Netherlands)...... 2289

Telomerase Activity and hTERT Protein Expression in Meningiomas: An Analysis In Vivo Versus In Vitro. L. MAES, J.P.O. KALALA, R. CORNELISSEN, L. DE RIDDER (Ghent, Belgium) ...... 2295

Gemcitabine plus and Prednisone in the Palliative Treatment of Hormone-resistant Prostate Cancer (HRPC): A Phase II Study (GOAM 01.01 Study). A. CRICCA, A. MARINO, D. VALENTI, B. MELOTTI, E. AMADUCCI, C. GUARDIGLI, M. LENZI, G. MARTORANA, P. BULI, A.A. MARTONI, on behalf of Gruppo Oncologico Aree Metropolitane (GOAM) (Bologna, Italy)...... 2301

Laparoscopic Sentinel Node Mapping for Colorectal Cancer Using Infrared Ray Laparoscopy. K. NAGATA, S. ENDO, E. HIDAKA, J.-I. TANAKA, S.-E. KUDO, A. SHIOKAWA (Yokohama, Japan)...... 2307

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Correlation between Serum DNA Methylation and Prognosis in Gastric Cancer Patients. H. IKOMA, D. ICHIKAWA, H. KOIKE, D. IKOMA, N. TANI, K. OKAMOTO, T. OCHIAI, Y. UEDA, E. OTSUJI, H. YAMAGISHI (Kyoto, Japan) ...... 2313

Dose-finding Study of Added to and Followed by Concomitant and Radiotherapy in the Treatment of Locally Advanced Squamous Cell Carcinoma of the Head and Neck. F. RECCHIA, G. SAGGIO, A. CESTA, G. AMICONI, A. DI BLASIO, G. CANDELORO, M. VALERIANI, V. TOMBOLINI, S. REA (Rome; L’Aquila, Italy)...... 2317

Octreotide Long-acting Formulation (LAR) in Chronic Loperamide-refractory Diarrhea Not Related to Cancer Treatment. K. MYSTAKIDOU, E. KATSOUDA, E. TSILIKA, V. SMYRNIOTIS, I. VASSILIOU, M. TSIATAS, L. VLAHOS (Athens, Greece)...... 2325

Dermatomyositis Associated with Breast Cancer. D. PECTASIDES, M. KOUMPOU, A. GAGLIA, M. PECTASIDES, V. LAMBADIARI, E. LIANOS, G. PAPAXOINIS, TH. ECONOMOPOULOS (Athens; Piraeus, Greece) ...... 2329

Detection of HER-2/neu (c-erbB-2) Overexpression and Amplification in Breast Carcinomas with Ambiguous Immunohistochemical Results. A Further Contribution to Defining the Role of Fluorescent In Situ Hybridization. A. SIDONI, I. FERRI, A. CAVALIERE, G. BELLEZZA, M. SCHEIBEL, E. BUCCIARELLI (Perugia, Italy) ...... 2333

Primary and Metastatic Ovarian Cancer in Patients with Prior Breast Carcinoma. Pre-operative Markers and Treatment Results. A. TSERKEZOGLOU, S. KONTOU, G. HADJIELEFTHERIOU, N. APOSTOLIKAS, M. VASSILOMANOLAKIS, K. SIKIOTIS, E. SALAMALEKIS, P. TSEKE, G. MAGIAKOS (Athens; Ioannina, Greece)...... 2339

Association between Squamous Cell Carcinoma of the Head and Neck and Serum Folate and Homocysteine. A. ELEFTHERIADOU, T. CHALASTRAS, E. FEREKIDOU, I. YIOTAKIS, L. KYRIOU, M. TZAGARAKIS, E. FEREKIDIS, D. KANDILOROS (Athens, Greece) ...... 2345

Clinical and Biological Features of an Intranodal Palisaded Myofibroblastoma. U.M. COSENZA, G. GALATI, P. ZOFREA, S. MAGGI, A. MARASCO, M. CASTELLI, L. MASONI, A. BRESCIA (Rome, Italy)...... 2349

An Immunohistochemical Study of P53 and Ki-67 in Gastrointestinal Adenoma and Adenocarcinoma using Tissue Microarray H. ZHENG, K. TSUNEYAMA, C. CHENG, H. TAKAHASHI, Z. CUI, Y. MURAI, K. NOMOTO, Y. TAKANO (Toyama, Japan; Davis, CA, USA) ...... 2353

Ex Vivo Responsiveness of Head and Neck Squamous Cell Carcinoma to . R. DOLLNER, C. GRANZOW, K. TSCHOP, A. DIETZ (Leipzig; Heidelberg, Germany) ...... 2361

Low Pre-radiotherapy Prostate-specific Antigen Level is a Significant Predictor of Treatment Success for Postoperative Radiotherapy in Patients with Prostate Cancer. T. SASAKI, K. NAKAMURA, Y. SHIOYAMA, S. OHGA, T. TOBA, Y. URASHIMA, T. YOSHITAKE, H. TERASHIMA, H. KOGA, S. NAITO, H. NOMA, K. KOMATSU, A. YAMAGUCHI, Y. HIRATSUKA, T. HIRANO, K. HANADA, M. ABE, Y. FUJISAWA, H. HONDA (Fukuoka, Japan) ...... 2367

Vinorelbine-based Chemotherapy in Hormone-refractory Prostate Cancer. M.G. ZAMPINO, E. VERRI, M. LOCATELLI, G. CURIGLIANO, G. ASCIONE, A. SBANOTTO, A. ROCCA, F. VERWEIJ, V. MATEI, E. SCARDINO, O. DECOBELLI, A. GOLDHIRSCH, F. NOLÉ (Milan, Italy) ...... 2375

* The Role of Capecitabine in the Treatment of Colorectal Cancer in the Elderly. L.M. PASETTO, S. MONFARDINI (Padova, Italy)...... 2381 Contents continued on the preceding page Contents continued

Variations of Soluble Fas and Cytokeratin 18-Asp 396 Neo-epitope in Different Cancers During Chemotherapy. M.-F. PICHON, M. LABROQUÉRE, K. REZAÏ, F. LOKIEC (Saint-Cloud, France)...... 2387

Improved Quality of Life for Malignant Ascites Patients by Denver Peritoneovenous Shunts. K. TOMIYAMA, M. TAKAHASHI, T. FUJII, H. KUNISUE, Y. KANAYA, S. MARUYAMA, N. YOKOYAMA, A. NAKAO, M. SODA, N. SHIMIZU (Okayama; Hyogo, Japan; Pittsburgh, PA, USA) ...... 2393

Chemopreventive Effects of Khaya senegalensis Bark Extract on Human Colorectal Cancer. X.M. ANDROULAKIS, S.J. MUGA, F. CHEN, Y. KOITA, B. TOURE, M.J. WARGOVICH (Columbia; Clemson, SC, USA; Conakry; Bissau, Guinea) ...... 2397

Combined Radiotherapy and Razoxane in the Treatment of Chondrosarcomas and Chordomas. W. RHOMBERG, H. EITER, F. BÖHLER, S. DERTINGE (Feldkirch, Austria)...... 2407

Cancer in Pregnancy: Results of a Series of 32 Patients. S. DE CAROLIS, F. GRIMOLIZZI, S. GAROFALO, G. FATIGANTE, S. FERRAZZANI, B. CARDUCCI, A. CARUSO (Rome, Italy)...... 2413

Pre-operative Radiochemotherapy with for Resectable Locally-advanced Rectal Cancer: A Phase II Study. M.C. LEONARDI, M.G. ZAMPINO, F. LUCA, B.A. JERECZEK-FOSSA, E. PETAZZI, B. TATANI, R. LAZZARI, R. BIFFI, K. LORIZZO, E. MAGNI, D. SCANNIFFIO, F. ORSI, G. BONOMO, G. PETRALIA, C. TROVATO, C. CROSTA, B. ANDREONI, R. ORECCHIA (Milan, Italy)...... 2419

Oxaliplatin Combined with 5- and in Advanced Colorectal Cancer. M.G. ZAMPINO, K. LORIZZO, A. ROCCA, M. LOCATELLI, L. ZORZINO, S. MANZONI, C. MAZZETTA, N. FAZIO, R. BIFFI, F. DE BRAUD (Milan, Italy) ...... 2425

High-grade Gliomas: Results in Patients Treated with Adjuvant Radiotherapy Alone and with Adjuvant Radio-chemotherapy. M. VALERIANI, A. FERRETTI, P. FRANZESE, V. TOMBOLINI (L’Aquila, Italy)...... 2429

Individualization of the Subcutaneous Amifostine Dose During Hypofractionated / Accelerated Radiotherapy. M.I. KOUKOURAKIS, I. ABATZOGLOU, L. SIVRIDIS, M. TSARKATSI, H. DELIDOU (Alexandroupolis, Greece) ...... 2437

C677T Gene Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) in Meningiomas and High- grade Gliomas. A.M. KAFADAR, H. YILMAZ, D. KAFADAR, A. ERGEN, U. ZEYBEK, N. BOZKURT, C. KUDAY, T. ISBIR (Istanbul, Turkey) ...... 2445

Phase II Trial of Capecitabine and Vinorelbine as First-line Chemotherapy for Metastatic Breast Cancer Patients. M. GHOSN, J. KATTAN, F. FARHAT, F. YOUNES, J. GASMI (Beirut; Sidon, Lebanon; Boulogne, France)...... 2451

Hyperfractionated Radiotherapy and Multi-agent Chemotherapy (, ACNU and ) for High-grade Gliomas: A Prospective Study. K. OGAWA, Y. YOSHII, T. TOITA, A. SAITO, Y. KAKINOHANA, S. IRAHA, K. SUGIMOTO, Y. TSUCHIDA, W. TAMAKI, G. ADACHI, A. HYODO, S. MURAYAMA (Okinawa, Japan)...... 2457

Sudden Death due to Primary Intracranial Neoplasms. A Forensic Autopsy Study. T. VOUGIOUKLAKIS, A. MITSELOU, N.J. AGNANTIS (Ioannina, Greece) ...... 2463

HLA-G Expression in Gastric Cancer. S. ISHIGAMI, S. NATSUGOE, F. MIYAZONO, A. NAKAJO, K. TOKUDA, M. MATSUMOTO, H. OKUMURA, T. DOUCHI, S. HOKITA, T. AIKOU (Kagoshima, Japan)...... 2467 Contents continued on the preceding page Contents continued

Mcm-2 Protein Expression Predicts Prognosis Better than Ki-67 Antigen in Oral Cavity Squamocellular Carcinoma. J. SZELACHOWSKA, P. DZIEGIEL, J. JELEN–KRZESZEWSKA, M. JELEN, R. MATKOWSKI, A. POMIECKO, B. SPYTKOWSKA, M. JAGAS, I. GISTEREK, J. KORNAFEL (Wroclaw, Poland) ...... 2473

A Phase I Study of in Combination with for Advanced Lung Cancer Patients. H. KANEDA, T. KURATA, K. TAMURA, H. UEJIMA, K. NAKAGAWA, M. FUKUOKA (Osaka, Japan) ...... 2479

Treatment Results of Radical Surgery and Definitive Chemoradiotherapy for Patients with Submucosal Esophageal Squamous Cell Cancinomas. Y. TOH, T. OHGA, S. ITOH, A. KABASHIMA, K. YAMAMOTO, E. ADACHI, Y. SAKAGUCHI, T. OKAMURA, H. HIRATA (Fukuoka, Japan)...... 2487

Clinical Effectiveness of Tumor Markers in Squamous Cell Carcinoma of the Larynx. A. ELEFTHERIADOU, T. CHALASTRAS, E. FEREKIDOU, L. KYRIOU, I. YIOTAKIS, Z. PAPPAS, E. FEREKIDIS, D. KANDILOROS (Athens, Greece) ...... 2493

Primitive Neuroectodermal Tumor (PNET) of the Brain Diagnosed during Pregnancy. B. BODNER- ADLER, K. BODNER, H. ZEISLER (Vienna, Austria) ...... 2499

Pre- and Post-operative Plasma Big Endothelin-1 Levels in Patients with Gastric Carcinoma Undergoing Radical Gastrectomy. X.-J. TENG, Z.-X. SHEN, J.-J. XIANG, L. SHEN, L. YUAN, J. GUO, X.-L. WANG (Wuhan, China) ...... 2503

* Review (page 2381)