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International Quality Assurance Programme (Iqap) INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Summary Report SEIZED MATERIAL 2018/2 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Table of contents Introduction Page 3 Comments from the International Panel of Forensic Experts Page 3 NPS reported by ICE participants Page 5 Codes and Abbreviations Page 7 Sample 1 Analysis Page 8 Identified substances Page 8 Statement of findings Page 13 Identification methods Page 23 Summary Page 29 Z-Scores Page 30 Sample 2 Analysis Page 34 Identified substances Page 34 Statement of findings Page 39 Identification methods Page 49 Summary Page 55 Z-Scores Page 56 Sample 3 Analysis Page 59 Identified substances Page 59 Statement of findings Page 64 Identification methods Page 74 Summary Page 80 Z-Scores Page 81 Sample 4 Analysis Page 84 Identified substances Page 84 Statement of findings Page 89 Identification methods Page 99 Summary Page 105 Z-Scores Page 106 Test Samples Information Samples Comments on samples Sample 1 SM-1 was prepared from a seizure containing 22.7 % (w/w) Cocaine base. The test sample also contained lactose with methylecgonine, benzoylecgonine and cinnamoyl cocaine as minor components Sample 2 SM-2 was prepared from a seizure containing 9.8 % (w/w) 3,4-methylenedioxypyrovalerone base. The test sample also contained lactose. Sample 3 SM-3 was prepared from a seizure containing 19.6% (w/w) Metamfetamine base. The test sample also contained lactose Sample 4 SM-4 was prepared from a seizure containing 7.1 % (w/w) Amfetamine base. The test sample also contained caffeine and lactose Samples Substances Concentrations Comments on substances Sample 1 Cocaine 22.7 % Lactose - Sample 2 3,4-Methylenedioxypyrovalerone 9.8 % Lactose - Sample 3 Lactose - Metamfetamine 19.6 % Sample 4 Amfetamine 7.1 % Caffeine - Lactose - 2018/2-SM (2) Copyright (c) 2019 UNODC INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Introduction An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both developing and developed countries to continuously monitor their performance in drug testing on a truly global scale. This report provides information on analytical results of laboratories participating in the Seized Materials (SM) group. In order to maintain confidentiality, the participating laboratories have been assigned random “Web Codes”, which change every round. The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential report is provided to each laboratory on its own performance. The overall analytical results are reviewed by the UNODC’s International Panel of Forensic Experts which oversees the implementation of these exercises, and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of the performance and capacity of participating laboratories and enable UNODC to tailor technical support in the laboratory sector for greatest impact. The ICE programme is a UNODC mandated activity and is implemented through regular budget funds and through the UNODC Global Scientific and Forensic Programme – Support Project (GLOU54), which operationalizes the forensic aspects of the UNODC Thematic Programme on Research, Trend Analysis and Forensics" Comments from the International Panel of Forensic Experts Participation of Laboratories In the 2018/2 round of the ICE programme, results were submitted within both the Sei zed Materials (SM) and Biological Specimens (BS) test groups by 231 laboratories in 77 countries. Within the SM test group, there were 194 participating laboratories from 69 countries and within the BS test group, results were submitted by 82 laboratories from 46 countries. Qualitative Analysis Colour tests (53% of participants) were the most commonly used screening technique for test samples in the SM test group, while GC-MS (91% of participants) was the most commonly used technique for identification/confirmation of the components in the test samples followed by FTIR (43% of participants). The results for the qualitative identification of the controlled substances in the SM test group, the number of false positive/negative results and the analyses not performed are shown in the table 1. Table 1. Performance of participants in the 2018/2 round of ICE. SM-1 SM-2 SM-3 SM-4 Test sample (Cocaine) (MDPV) (Metamfetamine) (Amfetamine) Correct identification by 100% 94.8% 98.4% 92.7% participants Number of false 2 7 7 7 positives Number of false 0 6 2 13 negatives Number of Analyses not 0 4 1 1 performed 2018/2-SM (3) Copyright (c) 2019 UNODC INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) With regard to false negative results reported, there were a total of 21 (6 for SM-2, 2 for SM-3 and 13 for SM- 4). In total, there were 23 false positive results for controlled substances or new psychoactive substances. Compared to the previous round, the overall number of false positive/negative results reported by ICE participants has increased. Laboratories reporting false positive or false negative results should investigate the reasons for this and corrective actions should be taken as soon as possible in order to continuously improve performance. There were a total of 6 analyses not performed, majority for SM-2. ICE participants should note that test samples can contain any of the substances in the ICE menu and screening and identification carried out should take this into account. Quantitative Analysis The number of participants who carried out quantitative analysis, 141 (72%) for SM-1, 55 (28%) for SM-2, 111 (57%) for SM-3 and 95 (48%) for SM-4 continues to be encouraging. It is also encouraging that 151 (77%) of participants in the SM test group performed quantitation and of these, 113 (74%) quantified more than one substance, 92 (60%) quantified more than 2 substances and 46 (30%) quantitated all four test samples. It is understood that quantitative analysis of controlled substances is often governed by local legislation and the requirements of prosecution. With regard to the analytical techniques used by participants performing quantitation, 56% used GC-FID, 32 % used UPLC/HPLC-DAD and 19% used mass spectrometric methods (i.e. GC-MS, GC-MS-MS, LC-MS, LC-MS-MS). z-scores obtained by participants in quantification are shown in table 2 below. Table 2. Quantitative performance of participants in the 2018/2 round of ICE. Test sample z-score SM-1 SM-2 SM-3 SM-4 (Cocaine) (MDPV) (Metamfetamine) (Amfetamine) |z| < 2, satisfactory 77% 82% 80% 83% 2 ≤ | z| ≤ 3, questionable 10% 7% 5% 7% |z| > 3, unsatisfactory 13% 11% 15% 10% According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signals in two successive rounds shall be taken that an anomaly has occurred that requires investigation. Participants with z-scores outside acceptable limits should review their quantification procedures as soon as possible. The following laboratories obtained a single action signal or warning signal in the two successive rounds of 2018/1 and 2018/2 and shall take this as an anomaly, which requires further investigation: 07RNYQ, 22YK4V, 2P2PU2, 4QMQQQ, 60XF00, 8TKCKC, 8XQEGQ, A8R888, AAPSTZ, CELGEE, ECOCCC, F9BYIQ, GU6GGK, HATVYH, HDYYZY, HRZZZ0, KOQ1NC, LC7LMZ, LLTO7L, NVWID3, PUTLIT, QMQ1QP, RPI8GV, T0PFVQ, WWWBLX and Y3XX1B. Of the 13 laboratories that obtained a single action or warning signal in ICE rounds 2017/2 and 2018/1 reported in the previous summary report, the following laboratories also obtained an action or warning signal in 2018/2: 07RNYQ, 2P2PU2, 4QMQQQ, 8TKCKC, AAPSTZ, HDYYZY, HRZZZ0, NVWID3, WWWBLX and Y3XX1B. Laboratories that need to perform quantitation routinely are encouraged to participate regularly in external proficiency testing or collaborative exercises such as the ICE programme. This will enable laboratories to assess the quality of their quantitative methods through the z-score values obtained. In addition to the use of z-scores as a measure of performance in quantitation, participants are encouraged to compare their results with the assigned values provided in individual quantification reports, to assess the accuracy of their quantitative performance. Laboratories reporting false positive or false negative results should investigate the root causes and corrective actions taken promptly in order to continuously improve performance. Participation in the ICE programme also helps in monitoring the effect of corrective actions. UNODC would like to acknowledge the valuable contribution of the Chemical Metrology Laboratory of the Health Sciences Authority, Singapore, for the provision of specific software used for the quantitative statistical calculations in the ICE programme. 2018/2-SM (4) Copyright (c) 2019 UNODC INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) New Psychoactive Substances (NPS) reported by laboratories participating in the 2018/2 round of the ICE programme During the 2018/2 round of ICE, participating laboratories provided information on NPS that had been identified in their laboratories. In total there were 175 reports of 116 substances. The most commonly reported substances were
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