International Quality Assurance Programme (Iqap)

Home , Free base, Misuse of Drugs Act 1971, Misuse of Drugs Act 1977

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)

INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Summary Report SEIZED MATERIAL 2018/2

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Table of contents Introduction Page 3 Comments from the International Panel of Forensic Experts Page 3 NPS reported by ICE participants Page 5 Codes and Abbreviations Page 7 Sample 1 Analysis Page 8 Identified substances Page 8 Statement of findings Page 13 Identification methods Page 23 Summary Page 29 Z-Scores Page 30 Sample 2 Analysis Page 34 Identified substances Page 34 Statement of findings Page 39 Identification methods Page 49 Summary Page 55 Z-Scores Page 56 Sample 3 Analysis Page 59 Identified substances Page 59 Statement of findings Page 64 Identification methods Page 74 Summary Page 80 Z-Scores Page 81 Sample 4 Analysis Page 84 Identified substances Page 84 Statement of findings Page 89 Identification methods Page 99 Summary Page 105 Z-Scores Page 106 Test Samples Information Samples Comments on samples Sample 1 SM-1 was prepared from a seizure containing 22.7 % (w/w) Cocaine base. The test sample also contained lactose with methylecgonine, benzoylecgonine and cinnamoyl cocaine as minor components

Sample 2 SM-2 was prepared from a seizure containing 9.8 % (w/w) 3,4-methylenedioxypyrovalerone base. The test sample also contained lactose.

Sample 3 SM-3 was prepared from a seizure containing 19.6% (w/w) Metamfetamine base. The test sample also contained lactose

Sample 4 SM-4 was prepared from a seizure containing 7.1 % (w/w) Amfetamine base. The test sample also contained caffeine and lactose

Samples Substances Concentrations Comments on substances Sample 1 Cocaine 22.7 % Lactose - Sample 2 3,4-Methylenedioxypyrovalerone 9.8 % Lactose - Sample 3 Lactose - Metamfetamine 19.6 % Sample 4 Amfetamine 7.1 % Caffeine - Lactose -

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Introduction

An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both developing and developed countries to continuously monitor their performance in drug testing on a truly global scale. This report provides information on analytical results of laboratories participating in the Seized Materials (SM) group. In order to maintain confidentiality, the participating laboratories have been assigned random “Web Codes”, which change every round.

The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential report is provided to each laboratory on its own performance. The overall analytical results are reviewed by the UNODC’s International Panel of Forensic Experts which oversees the implementation of these exercises, and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of the performance and capacity of participating laboratories and enable UNODC to tailor technical support in the laboratory sector for greatest impact.

The ICE programme is a UNODC mandated activity and is implemented through regular budget funds and through the UNODC Global Scientific and Forensic Programme – Support Project (GLOU54), which operationalizes the forensic aspects of the UNODC Thematic Programme on Research, Trend Analysis and Forensics"

Comments from the International Panel of Forensic Experts

Participation of Laboratories

In the 2018/2 round of the ICE programme, results were submitted within both the Sei zed Materials (SM) and Biological Specimens (BS) test groups by 231 laboratories in 77 countries. Within the SM test group, there were 194 participating laboratories from 69 countries and within the BS test group, results were submitted by 82 laboratories from 46 countries.

Qualitative Analysis

Colour tests (53% of participants) were the most commonly used screening technique for test samples in the SM test group, while GC-MS (91% of participants) was the most commonly used technique for identification/confirmation of the components in the test samples followed by FTIR (43% of participants). The results for the qualitative identification of the controlled substances in the SM test group, the number of false positive/negative results and the analyses not performed are shown in the table 1.

Table 1. Performance of participants in the 2018/2 round of ICE.

SM-1 SM-2 SM-3 SM-4 Test sample (Cocaine) (MDPV) (Metamfetamine) (Amfetamine)

Correct identification by 100% 94.8% 98.4% 92.7% participants

Number of false 2 7 7 7 positives Number of false 0 6 2 13 negatives Number of Analyses not 0 4 1 1 performed

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With regard to false negative results reported, there were a total of 21 (6 for SM-2, 2 for SM-3 and 13 for SM- 4). In total, there were 23 false positive results for controlled substances or new psychoactive substances. Compared to the previous round, the overall number of false positive/negative results reported by ICE participants has increased. Laboratories reporting false positive or false negative results should investigate the reasons for this and corrective actions should be taken as soon as possible in order to continuously improve performance. There were a total of 6 analyses not performed, majority for SM-2. ICE participants should note that test samples can contain any of the substances in the ICE menu and screening and identification carried out should take this into account.

Quantitative Analysis

The number of participants who carried out quantitative analysis, 141 (72%) for SM-1, 55 (28%) for SM-2, 111 (57%) for SM-3 and 95 (48%) for SM-4 continues to be encouraging. It is also encouraging that 151 (77%) of participants in the SM test group performed quantitation and of these, 113 (74%) quantified more than one substance, 92 (60%) quantified more than 2 substances and 46 (30%) quantitated all four test samples. It is understood that quantitative analysis of controlled substances is often governed by local legislation and the requirements of prosecution. With regard to the analytical techniques used by participants performing quantitation, 56% used GC-FID, 32 % used UPLC/HPLC-DAD and 19% used mass spectrometric methods (i.e. GC-MS, GC-MS-MS, LC-MS, LC-MS-MS). z-scores obtained by participants in quantification are shown in table 2 below.

Table 2. Quantitative performance of participants in the 2018/2 round of ICE.

Test sample z-score SM-1 SM-2 SM-3 SM-4 (Cocaine) (MDPV) (Metamfetamine) (Amfetamine) |z| < 2, satisfactory 77% 82% 80% 83% 2 ≤ | z| ≤ 3, questionable 10% 7% 5% 7% |z| > 3, unsatisfactory 13% 11% 15% 10%

According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signals in two successive rounds shall be taken that an anomaly has occurred that requires investigation. Participants with z-scores outside acceptable limits should review their quantification procedures as soon as possible.

The following laboratories obtained a single action signal or warning signal in the two successive rounds of 2018/1 and 2018/2 and shall take this as an anomaly, which requires further investigation: 07RNYQ, 22YK4V, 2P2PU2, 4QMQQQ, 60XF00, 8TKCKC, 8XQEGQ, A8R888, AAPSTZ, CELGEE, ECOCCC, F9BYIQ, GU6GGK, HATVYH, HDYYZY, HRZZZ0, KOQ1NC, LC7LMZ, LLTO7L, NVWID3, PUTLIT, QMQ1QP, RPI8GV, T0PFVQ, WWWBLX and Y3XX1B.

Of the 13 laboratories that obtained a single action or warning signal in ICE rounds 2017/2 and 2018/1 reported in the previous summary report, the following laboratories also obtained an action or warning signal in 2018/2: 07RNYQ, 2P2PU2, 4QMQQQ, 8TKCKC, AAPSTZ, HDYYZY, HRZZZ0, NVWID3, WWWBLX and Y3XX1B.

Laboratories that need to perform quantitation routinely are encouraged to participate regularly in external proficiency testing or collaborative exercises such as the ICE programme. This will enable laboratories to assess the quality of their quantitative methods through the z-score values obtained. In addition to the use of z-scores as a measure of performance in quantitation, participants are encouraged to compare their results with the assigned values provided in individual quantification reports, to assess the accuracy of their quantitative performance. Laboratories reporting false positive or false negative results should investigate the root causes and corrective actions taken promptly in order to continuously improve performance. Participation in the ICE programme also helps in monitoring the effect of corrective actions. UNODC would like to acknowledge the valuable contribution of the Chemical Metrology Laboratory of the Health Sciences Authority, Singapore, for the provision of specific software used for the quantitative statistical calculations in the ICE programme.

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New Psychoactive Substances (NPS) reported by laboratories participating in the 2018/2 round of the ICE programme

During the 2018/2 round of ICE, participating laboratories provided information on NPS that had been identified in their laboratories. In total there were 175 reports of 116 substances. The most commonly reported substances were synthetic cannabinoids (35%) followed by synthetic cathinones as shown in figure 1.

Phencyclidine-type Tryptamines substances 2% 6%

Phenethylamines 9% Synthetic cannabinoids 35%

Other substances 22%

Synthetic cathinones 26%

Figure 1. NPS reported by ICE laboratories during the 2018/2 round of IC E

In terms of the mode of action of the NPS reported by ICE participants, the predominant substances reported were synthetic cannabinoid receptor agonists (SCRA) (35%), while 34% were stimulants as shown in figure 2.

Sedatives/Hypnotics Others 5% 3%

Dissociatives Synthetic 5% cannabinoid receptor agonists 35% Opioids 8%

Hallucinogens 10%

Stimulants 34%

Figure 2. Mode of action of NPS reported by ICE participants in the 2018/2 round of ICE

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NPS most commonly reported by laboratories participating in ICE 2018/2

The substances most often reported by ICE participants was ketamine followed equally by the synthetic cannabinoid receptor agonists 5F-MDMB-PINACA (methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)- 3,3-dimethylbutanoate and 5F-MDMB-PICA (methyl 2-(1-(5-fluoropentyl)-1H-indole-3-carboxamido)-3,3- dimethylbutanoate.

For further details on these substances and others reported to the UNODC Early Warning Advisory, ICE participants can log on to the UNODC ICE portal and select the icon for the Early Warning Advisory on New Psychoactive substances as shown below.

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Codes and Abbreviations

(+) “positive”: Indicates that the analyte is identified; for presumptive tests (e.g. colour reactions), indicates that a positive reaction was obtained. (-) “negative”: Indicates that the analyte is not identified.

(ANP): Analysis not performed.

Tech Code Name 140 Colorimetric reactions 141 Marquis reagent (sulphuric acid, formaldehyde) 142 Cobalt thiocyanate 150 Thin Layer Chromatography 160 High/Ultra High Performance Liquid Chromatography 161 High Performance Liquid Chromatography with diode array detection 170 Gas Chromatography NPD 171 Gas Chromatography FID 172 Gas Chromatography ECD 180 Gas Chromatography/Mass Spectrometry 190 Fourier Transform Infrared Spectrometry 200 Spectrophotometry (visible, UV) 210 Others (specify) 211 NMR 220 Microcrystal test 230 Liquid chromatography/mass spectrometry 231 Liquid chromatography/tandem mass spectrometry 250 Raman Spectroscopy

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Sample 1 Analysis

Identified substances for Test Sample 1

Code Identified Substances 006FMT cocaine 02OWVV cocaina 07RNYQ Cocaíne Hydrochloride 0O73XC CLORHIDRATO DE COCAINA 14YQYB cocaine 1IIEIC Cocaine 1KOSTW Cocaine 1PSOP9 cocaine HCl 222A22 cocaine 22YK4V cocaine and its main metabolites 2333DY cocaine 2BSDEQ cocaine 2P2PU2 Cocaine 31933H cocaine 33Q3N2 Cocaine 3CUTP4 Cocaine 3EOHEE cocaine 3JJ2TA COCAINE 44N4AK cocaine 49LF34 Cocaine 4EF44P COCAINE 4FMLRF cocaine 4ITTTE cocaine 4QMQQQ Cocaine 4STTTT Cocaine 555HC5 Cocaine 55IZ55 cocaine 5BOT5R Cocaine 5W5519 COCAINE 60XF00 Cocaine HCl 64UHPY Cocaina 6C7TVN Cocaine 7HN7A7 Cocaine 7JGGMW cocaine 7P5A33 Cocaine 7S7SS2 Cocaine 7ULAFF Cocaine 7UN77R Cocaine Hydrochloride 7Z33IM cocaine 8288I1 Cocaine-Lactose

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Code Identified Substances 8828D8 Cocaine 8TKCKC cocaïne chlorhydrate 8XQEGQ Cocaine 9CKOOD Cocaine 9DKDUD cocaine 9LZ9YA Cocaïne 9N8FTT Cocaine 9ONAKN Cocaine 9QNQPB cocaine 9WFUHI Cocaine 9YN990 Cocaine A8R888 Cocaine AAPSTZ cocaine ADPI7V cocaine AEFKAT Cocaine AGJ544 cocaine AIQBL5 cocaine AIW1Z2 Cocaine ANAAAW Cocaine AOZMSG COCAINE 22.7% BEXBRB cocaine BLBOCB Cocaine Hydrochloride BSWNB0 cocaine BUHHL2 Cocaine BZZZIR Cocaine C9QQGT Cocaine CELGEE Cocaine CLRNDG Cocaine CMZFLS COCAINE HYDROCHLORIDE CPBBXT Cocaine CTRBHS Cocaine. D3UIUC Cocaine DIIBXI Cocaine Hydrochloride DPAIVA cocaine DYZ53I Cocaine hydrochloride ECOCCC cocaïne EDHZTN Cocaine EQWWGJ Cocaine ESWD79 Cocaine F0000S Cocaine F9BYIQ Cocaine FD4JOW Cocaine FPTIMV Test sample 2018/2/SM-1 contains cocaine GCFWS5 cocain

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Code Identified Substances GF7VNQ Cocaine GFFGAC COCAINE GKMCN5 Cocaine GU6GGK Cocaine H6MPDC Cocaine HCl + LACTOSE H8G1O8 cocaïne HATVYH Clorhidrato de Cocaina HDYYZY cocaine HEVEPB Cocaine and Lactose HGGHOG cocaine HHDUPI Cocaine HI4WNN Cocaine + Cis-cinnamoylcocaine HPIHHH cocaine hcl HRFHJD Cocaine HRZZZ0 Cocaine HUAI9B Cocaine ICZF4Z Cocaine IL7F1S cocaine IODUOV Cocaine IXI4IQ Cocaine JDZDJJ cocaine JXQBZB cocaine K59V35 Cocaine K9O99N cocaine HCl KHGLHU Cocaine KILSPH Cocaine KOQ1NC Cocaine KSIKUP cocaine KUVU4U cocaine L9LV6L Cocaine LC7LMZ Cocaine LLTO7L Cocaine, Lactose LTTTTQ Cocaine MFE65O cocaine + lactose MJMMJM cocaine MR1LVU Cocaine Hydrochloride MSFAND cocain MSHBVG cocaine N8BKMB Cocaine NAK5A7 COCAINE NCCCCR Cocaine NPEUNW Cocaine NSALLN COCAINE NVWID3 COCAINE

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Code Identified Substances OB929H cocaine OKBALQ Cocaine OLWSRI cocaine ORPCAT cocaine PCYCJC cocaine PM7GBZ Cocaine hydrochloride PMDM1U COCAINE PMR0Q7 cocaine PQIKKZ cocaine PUTLIT Cocaine QBF6VQ cocaine QJJYGQ cocaina QJOV22 Cocaine QMQ1QP Cocaine QORSXL Cocaine QPXWKT Cocaine QRCK2V cocaine QRDRJ1 Cocaine + Lactose QTQQQ1 cocaine R2YIAE cocaine and cinnamoyl cocaine isomer R7GREQ Cocaine RCBIBN cocaine RDRW1X cocaine RPI8GV Cocaine RRFXUO Cocaine S919AS Cocaine SBKWJS cocaine SHIGZS cocaine, lactose SRCKGX Cocaine SUSSDP Cocaine SV4SBQ Cocaine SYLJNC cocaine SYYY0F cocaine hydrochloride SZVWV9 cocain T0PFVQ Cocaine TELOLF Cocaine U3WKHW Cocaine U479HU Cocaine UHJIRN Cocaine UNNSU8 Cocaine USULOL Cocaine UTTTWF Cocaine V4HVM5 Cocaine VBO7OP cocaine

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Code Identified Substances W7K0RA cocaine WEJJEJ Cocaine HCl WMUWWC cocaine and metabolites WPE9JA cocaine WV88U8 COCAINE WWWBLX Cocaine XGLCLJ cocaine, allopseudococaine,norcocaine,cinnamoylcocaine,benzoylcocaine,ecgonine methyl ester XLNP6X Cocaine XUE0RE Cocaine Y3XX1B cocaine Y68SYY COCAINE YMK92M cocaine YQELRV cocaine YQXDTM cocaine YS66H6 cocaine YSSSDR cocaine YYONQA cocaine Z00LTY Cocaine Z7F75I COCAINE Z7JWAE Cocaine Hydrochloride ZJZZZ3 Cocaine

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Statement of findings for Test Sample 1

Code Cocaine Lactose 006FMT + + MARQIUS REAGENT: negative result, COBALT THIOCYANATE: positive result, GC-MS: cocaine (compared with library MS spectrum of cocaine), FTIR: cocaine (compared with IR spectrum of cocaine), FTIR: lactose (spectrum of ethanol extract residue compared with IR spectrum lactose) 02OWVV + - 28.7 % de cocaína HCL 07RNYQ + ANP Powder contains cocaine - 21,8 % as hydrochloride 0O73XC + + PRUEBA DE SCREENING: TIOCIANATO DE COBALTO POSITIVO, PARA CLORUROS NITRATO DE PLATA PRECIPITADO POSITIVO (+) CROMATOGRAFIA EN CAPA FINA Rf CORRESPONDE A COCAINA, FTIR ESPESTRO PICOS ESPECIFICOS PARA COCAINA 14YQYB + ANP SM1 contains 19.9% cocaine. 1IIEIC + + This sample is cocaine. 1KOSTW + -

1PSOP9 + + 21,54 % cocaine base, (norcocaine, trans,cis - cinnamoylcocaine, methyl-ecgonidine), laktose, 222A22 + ANP also detected: anhydroecgonine methyl ester, benzoic acid 22YK4V + ANP tested by gc msd 2333DY + + laktóz 2BSDEQ + + White powder containing 21.6%w/w cocaine and lactose 2P2PU2 + + Cocaine was identified in SM1. Percentage as base is 25.75 %. In addition Ecgonidine and lactose were identified. 31933H + +

33Q3N2 + ANP Item 2018/2/SM-1 found to contain Cocaine. 3CUTP4 + + Lactose 3EOHEE + ANP cocaine 3JJ2TA + ANP

44N4AK + +

49LF34 + + The test sample 2018/2/SM-1 contains 21.22 % m/m cocaine base. 4EF44P + + LACTOSE

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Code Cocaine Lactose 4FMLRF + + Cocaine in mixture with lactose and impurities 4ITTTE + + Also contains lactose 4QMQQQ + - Cocaine was found in the sample 4STTTT + ANP COCAINE is controlled by the Misuse of Drugs Act (as amended) as a Class A drug. 555HC5 + + Cocaine was identified by TLC and GC/MS ,quantified by GC. 55IZ55 + + cocaine was detected 5BOT5R + ANP

5W5519 + + LACTOSE 60XF00 + - contain Cocaine 21.14% as base 64UHPY + + Clorhidrato de Cocaina y lactosa 6C7TVN + + The test sample 2018/2/SM-1 was found to contain cocaine and lactose. 7HN7A7 + ANP In cobalt thoocyanate test, violet colour appears.We confirm with TLC and GCMS. 7JGGMW + + cocaine + lactose 7P5A33 + ANP

7S7SS2 + + The sample contains Cocaine 7ULAFF + ANP Test sample 2018/2/SM-1 was confirmed to contain cocaine, a DEA schedule II substance. 7UN77R + + The sample 2018/2/SM-1 was found to contain 224 milligrams of a white powder. This powder was found to contain a mixture of cocaine hydrochloride and lactose. The purity of cocaine was found to be 25% calculated as salt form. 7Z33IM + ANP It include cocaine, also minor components which benzoyl Ecgonine and Andhydroecgonine methyl ester. 8288I1 + +

8828D8 + + The sample contains cocaine which is listed as a controlled drug according to french order, appendix I of February 22nd 1990. 8TKCKC + + cocaïne chlorhydrate (22,9% as base) + lactose 8XQEGQ + + Lactose

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Code Cocaine Lactose 9CKOOD + ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 2. (2) Cocaine (benzoylmethylecgonine) calculated as the hydrochloride 23 % (w/w) 9DKDUD + + cocaine 24% base - Lactose 9LZ9YA + - 25% 9N8FTT + + Mass spectrometry profile correlation between sample and reference material certified 9ONAKN + ANP SM-1 was found to contain 21.3% cocaine 9QNQPB + + lactose 9WFUHI + - The powder was analysed and found to contain Cocaine. A further sample of the powder was analysed and found to contain 22% (weight for weight) Cocaine. Cocaine is a class A controlled drug within the provisions of the Misuse of Drugs Act 1971. 9YN990 + ANP Sample SM-1 found to contain Cocaine. A8R888 + + SM 01 was found to contain cocaine Hcl and lactose AAPSTZ + ANP

ADPI7V + + lactose AEFKAT + + The sample contains Cocaine*HCl and Lactose, with 22.52% Cocaine base AGJ544 + ANP

AIQBL5 + ANP

AIW1Z2 + ANP Controlled drug, Cocaine, present in sample. Concentration approx 22% ANAAAW + + Sample 2018/2/SM-1 contains cocaine, lactose and cocaine derivates as minor components. Cocaine base concentration is (17,1 ± 0,2) %. AOZMSG + -

BAYSRL + +

BEXBRB + ANP Examination of sample SM-1 revealed the presence of cocaine BLBOCB + + the sample contains cocaine hydrochloride (22.3 +/- 0.4 % as cocaine free base) and lactose BSWNB0 + ANP

BUHHL2 + ANP From screening test using (CT) and from confirmation test using (GC-MS), the sample was found to contain the controlled drug (Cocaine).

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Code Cocaine Lactose BZZZIR + ANP SM-1 contain Cocaine which is controlled under Malaysian Dangerous Drug Act 1952 C9QQGT + + Using the techniques CR, TLC, GC-MS and FT-IR sample was found to contain Cocaine and Lactose CELGEE + ANP Sample tested positive for cocaine during screening with GC-MS. The latter was confirmed using GC-MS. The % purity by weight was 25.03%. CLRNDG + + Sample contains %23 cocaine CMZFLS + + A) One brown tinted glass container, labelled "2018/2/SM-1" "6, with attached black plastic lid that contained 209 milligrams of a white powder. This white powder was found to contain Cocaine Hydrochloride at an average purity of 23% in the salt form. Cocaine Hydrochloride is a Class A drug under the provisions of the Misuse of Drugs Act 1971 (as amended). Lactose is not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended).

CPBBXT + + We found a mixture of cocaine and lactose. The concentration of cocaine is 26.0% w/w. CTRBHS + ANP This sample was found to contain Cocaine, which is a Class A controlled substance under the Misuse of Drugs Act 1971. D3UIUC + ANP The sample contain cocaine DIIBXI + + Item 2018/2/SM-1 was found to contain one glass vial which held 225 milligrams of white powder. This powder contained an average of 25% COCAINE HYDROCHLORIDE. DPAIVA + + lactose DYZ53I + +

ECOCCC + + SM1 contient de la cocaïne avec du lactose, de l'ecgoninemethylester et de la cinnamoylcocaïne. EDHZTN + ANP One glass bottle containing 0.22 grammes of a powder containing 0.04 grammes of cocaine. EQWWGJ + ANP In the sample 2018/2/SM1 was detected the presence of cocaine as base in percentage by weight of 22,7 %. ESWD79 + + Also it was found as a diluent: lactose. F0000S + ANP No F9BYIQ + -

FD4JOW + + the sample contains cocaine and Lactose FPTIMV + +

GCFWS5 + ANP

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Code Cocaine Lactose GF7VNQ + + Lactose is also present. GFFGAC + + WAS FOUND COCAINE 20.8 (+/-) 1.4% AND LACTOSE GKMCN5 + ANP The sample was found to contain 21.9% of cocaine (as base). GU6GGK + ANP

H6MPDC + + The SCOTT test was able to observe a positive reaction to Cocaine (Blue color). Also used the MARQUIS test but without any reaction. What came to be confirmed after the application of TLC and FTIR tests. With FTIR, it was also possible to observe the presence of LACTOSE For TLC, a glass plate (20 × 20 cm) coated with silicon oxide was used. The solvent used was dichloromethane and the eluent used was methanol. Finally the plaque was observed using ultaviolet light the wavelength of approximately 254 nm and subsequently revealed using the developer of Dragendorf. H8G1O8 + + Cocaïne is sheduled as illicit drug in France. HATVYH + + Lactosa, Acido benzoico, Ecgonina Metil Ester, Norcocaina, Ecgonidina Metil Ester, Cis- Cinnamoilcocaina, Trans-Cinnamoilcocaina y Benzoilecgonina HDYYZY + ANP

HEVEPB + + The Test sample 2018/2/SM-1 was analyzed by Thin Layer Chromatography technique and was found to contain Cocaine and Lactose. HGGHOG + ANP

HHDUPI + ANP Cocaine is a Class A controlled drug subject to the provisions of the Misuse of Drugs Act 1971. The purity was ~22% expressed as base. HI4WNN + ANP Substance routinely detected. HPIHHH + + lactose HRFHJD + + On analysis, I found the sample "SM-1" containing Cocaine and Lactose HRZZZ0 + ANP - HUAI9B + + The sample contained 22.6% (w/w) Cocaine (base) Lactose also detected in the sample. ICZF4Z + + The sample contains 22.8% ± 1.4%. Also contain lactose IL7F1S + + The sample contains 20,17±0,77 weight% cocaine-base. The sample also contains lactose. IODUOV + ANP Powder containing cocaine

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Code Cocaine Lactose IXI4IQ + ANP

JDZDJJ + +

JXQBZB + + cocaine + lactose K59V35 + + 2018/2/SM-1 contains Cocaine. It also contains anhydroecgonine methyl ester, ecgonine methyl ester, ecgonine, cinnamoylcociane isomers (cis and trans) and benzoylecgonine. It also contains lactose. K9O99N + + lactose KHGLHU + + Cocaine in lactose powder KILSPH + ANP White powder and odorless KOQ1NC + +

KSIKUP + + cocaine and lactose KUVU4U + + In the analisys was obteined (cocaine), which controled substance and lactose which is uncontroled substance for Colombia L9LV6L + ANP

LC7LMZ + + It has been detected the presence of cocaine in the sample. LLTO7L + + This powder was found to contain cocaine together with the adulterant lactose LTTTTQ + ANP Sample 2018/2/SM-1 was found to contain cocaine. MFE65O + + The sample was analyze by GC-MS with differents solvents: Methanol, chloroform, ethanol and ethanol with internal standard. MJMMJM + - The sample contains 20.5% cocaine as a free base MR1LVU + + Sample 2018/2/SM-1 contained Cocaine Hydrochloride, at a concentration of 22% (calculated as base), together with the adulterant Lactose. Cocaine Hydrochloride is a Class A controlled drug under the provision of the Misuse of Drugs Act 1971 (as amended). Lactose is not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). MSFAND + - lactose MSHBVG + + found cocaine with purity of 23 % N8BKMB + ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule 1 2. (2) Cocaine (benzoylmethylecgonine) calculated as the hydrochloride 24 % (w/w)

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Code Cocaine Lactose NAK5A7 + ANP Sample 2018/2/SM-1 was found to contain cocaine.

NCCCCR + + SM-1 was contained cocaine base.The test sample also contained lactose, methylecgonidine NPEUNW + + A composite was formed from 1 unit for testing of 1 unit received. Cocaine hydrochloride and lactose confirmed in the composite. NSALLN + ANP TEST SAMPLE 2018/2/SM -1 CONTAIN COCAINE NVWID3 + + After chemical analysis was performed the sample was contained COCAINE and Lactose . OB929H + ANP

OKBALQ + ANP

OLWSRI + ANP It include only cocaine ORPCAT + + Table 1 Schedule 1, Narcotic substances (not used by medicine) PCYCJC + ANP cocaine is controlled by the Royal Decree of the 6th of september 2017 PM7GBZ + ANP The sample contains Cocaine hydrochloride and traces of caffeine and phenacetine. The purity of the sample is 26.16% as cocaine base. PMDM1U + ANP White powder material that contains drug under international controle - COCAINE. PMR0Q7 + + positive for illicit substance PQIKKZ + ANP

PUTLIT + ANP The sample contains cocaine. QBF6VQ + ANP cocaine QJJYGQ + + cocaina clorhidrato y lactosa QJOV22 + ANP It include only cocaine QMQ1QP + + The sample contains cocaine and lactose as an adulterant. Cocaine as a psychoactive substance is controlled in Poland. QORSXL + + Cocaine (21.1%) and lactose QPXWKT + + Presence of cocaine hydrochloride and lactose was detected in the sample. The sample also contained multitude of trace level alkaloid impurities (cis/trans)cinnamoylcocaine, methyl ester ecgonine, benzoyl ecgonine. QRCK2V + + lactose

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Code Cocaine Lactose QRDRJ1 + + In the 2018/2/SM-1 it was proved presence of Cocaine and Lactose, with a quantification as base of 22.7%. It was also proved the presence of ecgonidine methylester and cynnamoilcocaine QTQQQ1 + ANP cocaine was detected by GC/MS and quantified by GC/FID R2YIAE + - Examination and analyses performed on the solid in SM-1 showed it to contain cocaine hydrochloride (a central stimulant) and cinnamoyl cocaine isomer R7GREQ + ANP Cocaine confirmed in SM-1. RCBIBN + + cocaine RDRW1X + ANP It include only cocaine RPI8GV + + Identified by GCMS & LCMSMS technique and quantified by GC-FID technique. RRFXUO + + Sample contained cocaine as hydrochloride and LACTOSE. Identification of cocaine by FTIR and GC/MS, quantification by GC/FID. Identification of LACTOSE by FTIR and Colorimetric Reactions (MolishTest). S919AS + - Sample turned white to blue colour with Cobalt ThioCyanate test and Cocaine was found in GCMS analysis SBKWJS + + ./. SHIGZS + + The sample contains cocaine which is scheduled as illicit drug in France. The lactose is not scheduled as illicit drug in France. It's a cutting agent. SRCKGX + + The sample contains cocaine. The content of cocaine is determined to 24 % (as cocainehydrochloride). Cocaine is a controlled substance in X. SUSSDP + -

SV4SBQ + ANP Powder contains cocaine. Cocaine is a controlled drug under the Misuse of Drugs Acts, 1977 to 2016. The cocaine in this case is not exempt from control under subsection (1) of Section 3 of the Misuse of Drugs Act, 1977 under the terms of the Misuse of Drugs (Exemption) Order, 2017. The Exemption Order does not provide for an exemption in respect of Section 15 of the Misuse of Drugs Act, 1977. The cocaine content of the powder was found to be 21.6 percent. SYLJNC + ANP The sample contains cocaine (23.4%) SYYY0F + + White powder containing by weight 24.8%w/w cocaine expressed as free base SZVWV9 + +

T0PFVQ + - The analysis confirmed that the SM-1 contains cocaine 19.3% w/w. TELOLF + + In the sample SM-1 there is a cocaine. Cocaine is on the list of drugs.

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code Cocaine Lactose U3WKHW + -

U479HU + - Cocaine UHJIRN + -

UNNSU8 + ANP Based on the above analysis, the sample was found to contain cocaine USULOL + ANP Satisfied with result obtained UTTTWF + + Cocaine cut with lactose was identified V4HVM5 + + The sample contained 19.6% cocaine (w/w base). The sample also contained lactose and cinnamoyl cocaine, norcocaine, methylecgonine and anhydroecgonine methyl ester as minor components. VBO7OP + - Non addulterants W7K0RA + ANP this finding was obtained with Cobalt thiocyanate test and thin layer chromatography WEJJEJ + + Base Cocaine 21.80+-1.96% (w/w) and Lactose WMUWWC + - cocaine ecgoninametilester benzoilecgonina WPE9JA + + cocaine was detected by GC/MS, confirmed by FTIR and quantified by GC/FID WV88U8 + + LACTOSE WWWBLX + ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 2. (2) Cocaine (benzoylmethylecgonine) calculated as the hydrochloride 19 % (w/w) XGLCLJ + + The major compound we founded in sm-1 after GC/MS injection is cocaine, the overs compounds were in trace XLNP6X + + Cocaine and Lactose XUE0RE + + The sample contains 19.61 % of Cocaine and also contains Benzoylecgonine and Ecgonine methyl ester Y3XX1B + + samle is mixture of cocaine and lactose Y68SYY + ANP On analysis of a representative sample of the powder cocaine was detected with a purity of approximately 23% (calculated as base). YMK92M + ANP In the test simple 2018/2/SM-1 was detected cocaine YQELRV + + The sample contains cocaine. The concentration has not been determined.

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code Cocaine Lactose YQXDTM + ANP White powder containing 23.8%w/w of cocaine YS66H6 + ANP found cocaine 22.0%ww YSSSDR + +

YYONQA + ANP White powder containing cocaine (24.5%w/w) wich is controlled by national law Z00LTY + ANP 2018/2/SM-1 has been detected containing Cocaine. Z7F75I + ANP ECGONIDINE, ECGONINE METHYL ESTER, CINNAMOYLCOCAINE Z7JWAE + ANP The white powder was analysed and found to contain Cocaine Hydrochloride. ZJZZZ3 + - Cocaine and sugar are found due to our analysis in the identification part. In the quantification part, the ratio of cocaine is found as 22.4 %

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Identification methods for Test Sample 1

Legend : S ... used for Screening I ... used for Identification SI ... used for both

Analytical Technique Codes Code 140 141 142 150 160 161 171 180 190 200 211 230 231 250 210 006FMT S S S SI I 02OWVV SI SI I SI 07RNYQ SI I I 0O73XC S S I I 14YQYB SI SI SI S immunichromatography 1IIEIC S I I 1KOSTW I I 1PSOP9 SI I I 222A22 S I I 22YK4V SI I 2333DY I SI SI 2BSDEQ I SI I 2P2PU2 S S I I S Fast blue B test 31933H S S S SI I 33Q3N2 S I 3CUTP4 I SI I 3EOHEE SI 3JJ2TA S S S I 44N4AK S I I 49LF34 I SI 4EF44P SI I 4FMLRF I S I I S 4ITTTE I SI I 4QMQQQ S S SI 4STTTT S S I 555HC5 S I I 55IZ55 SI I 5BOT5R SI 5W5519 SI I 60XF00 S S I I I 64UHPY SI S S I I I 6C7TVN S S S SI I 7HN7A7 S S I I 7JGGMW SI SI

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 250 210 7P5A33 I I I SI Rapid test 7S7SS2 S I I 7ULAFF S S S I 7UN77R S S I I S Simons Reagent 7Z33IM SI SI I SI 8288I1 S S I I 8828D8 I I 8TKCKC I I 8XQEGQ S I I I 9CKOOD S I I GC-FTIR 9DKDUD SI 9LZ9YA S I 9N8FTT I I 9ONAKN S S I 9QNQPB I I SI I 9WFUHI S I 9YN990 S I A8R888 S I SI S AAPSTZ S S S I S ADPI7V S I SI SI AEFKAT S I AGJ544 SI AIQBL5 SI SI I AIW1Z2 SI I GC-IRD ANAAAW S S S I I AOZMSG S SI SI BAYSRL SI I BEXBRB S I BLBOCB S S S I I I I GC/MS/MS BSWNB0 SI BUHHL2 S S I S Negms BZZZIR S S S I C9QQGT S S S I I CELGEE SI CLRNDG S I I CMZFLS S S I I S Simons Reagent CPBBXT SI SI SI I I CTRBHS S S I D3UIUC SI ASAP-QTOF

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 250 210 DIIBXI S S S I I DPAIVA I SI I DYZ53I S I I I I ECOCCC S I I I I HPLC/RID EDHZTN S S I SI I EQWWGJ S S I S TANRED ESWD79 I SI F0000S S S I I F9BYIQ S I SI FD4JOW S I I FPTIMV SI I I GCFWS5 S S I I GF7VNQ I I S GFFGAC S S I I GKMCN5 I SI GU6GGK SI H6MPDC S S S I I H8G1O8 I SI I HATVYH S I I HDYYZY I SI HEVEPB S S SI S Fast Blue B Salt Test HGGHOG S S I HHDUPI S S I HI4WNN S S I HPIHHH SI I HRFHJD S I I HRZZZ0 SI HUAI9B S S S I I I ICZF4Z S I I IL7F1S S I SI I IODUOV S I I SI IXI4IQ I JDZDJJ I S JXQBZB S I I K59V35 I I I S I SI SI I I K9O99N I SI KHGLHU I SI I KILSPH S S SI I KOQ1NC S I I SI

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 250 210 KSIKUP I SI I KUVU4U S S I I L9LV6L S I LC7LMZ SI S I LLTO7L S S I I LTTTTQ S S SI MFE65O SI I MJMMJM SI MR1LVU S S I I MSFAND SI MSHBVG SI I N8BKMB S I I I GC-FTIR NAK5A7 I SI NCCCCR I SI I NPEUNW SI I NSALLN S I NVWID3 SI S I OB929H SI SI SI I OKBALQ SI I OLWSRI S I SI SI ORPCAT S S S I I I PCYCJC I S PM7GBZ S S S I PMDM1U S S I PMR0Q7 S S S I I PQIKKZ SI PUTLIT SI QBF6VQ S S S I QJJYGQ S S S I I I I QJOV22 SI SI SI QMQ1QP SI I Tollens reaction QORSXL S I QPXWKT S I I I S QRCK2V I I SI I QRDRJ1 I SI I I I QTQQQ1 SI R2YIAE S S S I I I R7GREQ S S S I I RCBIBN SI SI SI I SI I

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 250 210 RDRW1X S I S I I RPI8GV I S S SI I I RRFXUO I SI I S919AS S S S I I SBKWJS SI SI SHIGZS S SI I I SRCKGX I I SUSSDP I S SV4SBQ I I SYLJNC S S S I I SYYY0F I SI SZVWV9 SI I T0PFVQ S S S I I TELOLF S S S I I I I U3WKHW SI SI SI I U479HU S S I UHJIRN S S S I I UNNSU8 S I USULOL S I UTTTWF S S I I V4HVM5 I SI VBO7OP I I I SI W7K0RA S S I WEJJEJ S S S I I I SI Duquenoise WMUWW S S I I S S C WPE9JA SI I WV88U8 S I WWWBL S I I GC-FTIR X XGLCLJ I S XLNP6X I SI I XUE0RE I SI I Y3XX1B SI I I I I Y68SYY S S I I HRMS YMK92M I YQELRV I I S Raman YQXDTM I SI YS66H6 SI YSSSDR SI

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 250 210 YYONQA I SI Z00LTY SI I Z7F75I S S S I I Z7JWAE S I I ZJZZZ3 SI I

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

RESPONSE SUMMARY FOR TEST SAMPLE 1

Participants: 194

The response summary of all 194 participating laboratories for the identification of SM-1, frequency of use of screening and identification techniques and false positives and negatives:

Correct identification of Test Sample-1:

Substance Name Number of laboratories Cocaine 194 Lactose 101

False positives for Test Sample-1:

Round Code Substance Reported Tech Code PM7GBZ Caffeine 180 WMUWWC Morphine 171, 180

False negatives for Test Sample-1 with respect to Cocaine (techniques(s) used):

There were no false negative results for SM-1

Analysis not performed for Test Sample-1 with respect to Cocaine:

All participating laboratories carried out analysis for Cocaine

Frequency of use of screening, identification and quantification techniques:

Response Summary Participants 194

Technique 140 141 142 150 160 161 171 180 190 200 210 211 230 231 250 Screening (No.) 66 74 65 20 2 4 8 70 17 1 2 0 1 0 4 (%) 34.0 38.1 33.5 10.3 1.0 2.1 4.1 36.1 8.8 0.5 1.0 0.0 0.5 0.0 2.1 Identification (No.) 21 11 10 39 6 16 27 178 85 3 10 2 3 5 4 (%) 10.8 5.7 5.2 20.1 3.1 8.2 13.9 91.8 43.8 1.5 5.2 1.0 1.5 2.6 2.1 Quantification (No.) 0 0 0 1 12 24 77 21 1 0 2 0 1 1 0 (%) 0.0 0.0 0.0 0.7 8.5 17.0 54.6 14.9 0.7 0.0 1.4 0.0 0.7 0.7 0.0

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Score Report per Sample per Substance:

Round: 2018/2 Substance: SM-1; Cocaine Robust average: 22.4% UNODC value: 22.7%

Z-scores can be interpreted by participants in line with ISO 13528:2005, section 7.4.2 and ISO/IEC guide43-1:1997(E) as follows: IzI < 2 = satisfactory 2 ≤ IzI ≤ 3 = questionable IzI > 3 = unsatisfactory According to the recommendations in ISO 13528:2005, an unsatisfactory z-score is considered to give an action signal and a questionable z-score is considered to give a warning signal. A single action signal or warning signal in two successive rounds shall be taken that an anomaly has occurred that requires investigation.

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Score Report per Sample per Substance:

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Scores for Test Sample 1

Cocaine Cocaine Deviation Deviation Code Concentration from Code Concentration from z-score z-score (mass%) robust (mass%) robust average average 7P5A33 7.2 -15.2 -12.8 MR1LVU 22.0 -0.4 -0.4 QMQ1QP 12.6 -9.8 -8.2 3JJ2TA 22.0 -0.4 -0.4 WWWBLX 16.6 -5.8 -4.9 31933H 22.0 -0.4 -0.4 ANAAAW 17.1 -5.3 -4.5 YMK92M 22.1 -0.3 -0.3 MFE65O 17.9 -4.5 -3.8 DPAIVA 22.1 -0.3 -0.3 SHIGZS 18.0 -4.4 -3.7 DIIBXI 22.2 -0.3 -0.3 T0PFVQ 19.3 -3.1 -2.6 SBKWJS 22.2 -0.2 -0.2 07RNYQ 19.4 -3.0 -2.6 DYZ53I 22.3 -0.1 -0.2 V4HVM5 19.6 -2.8 -2.4 HGGHOG 22.3 -0.1 -0.1 XUE0RE 19.6 -2.8 -2.4 AIQBL5 22.3 -0.1 -0.1 A8R888 19.8 -2.6 -2.3 UHJIRN 22.3 -0.1 -0.1 14YQYB 19.9 -2.5 -2.1 3CUTP4 22.3 -0.1 -0.1 LLTO7L 20.0 -2.4 -2.1 BLBOCB 22.3 -0.1 -0.1 IL7F1S 20.2 -2.2 -1.9 IXI4IQ 22.3 -0.1 -0.1 Y3XX1B 20.4 -2.0 -1.8 ZJZZZ3 22.4 0.0 -0.1 222A22 20.4 -2.0 -1.8 4FMLRF 22.4 0.0 -0.1 MJMMJM 20.5 -1.9 -1.6 RRFXUO 22.4 0.0 0.0 9CKOOD 20.6 -1.8 -1.6 7UN77R 22.5 0.1 0.0 GU6GGK 20.8 -1.6 -1.4 9N8FTT 22.5 0.1 0.0 GFFGAC 20.8 -1.6 -1.4 SZVWV9 22.5 0.1 0.0 EDHZTN 20.8 -1.6 -1.4 FPTIMV 22.5 0.1 0.0 CMZFLS 20.9 -1.5 -1.3 AEFKAT 22.5 0.1 0.0 YSSSDR 21.0 -1.4 -1.3 H8G1O8 22.6 0.2 0.1 HATVYH 21.0 -1.4 -1.2 AGJ544 22.6 0.2 0.1 4STTTT 21.0 -1.4 -1.2 OKBALQ 22.6 0.2 0.1 QORSXL 21.1 -1.3 -1.1 QTQQQ1 22.6 0.2 0.1 60XF00 21.1 -1.3 -1.1 QRCK2V 22.6 0.2 0.1 49LF34 21.2 -1.2 -1.0 HUAI9B 22.6 0.2 0.1 9ONAKN 21.3 -1.1 -1.0 HI4WNN 22.6 0.2 0.1 SRCKGX 21.3 -1.1 -0.9 QJOV22 22.6 0.2 0.1 1KOSTW 21.4 -1.0 -0.9 UTTTWF 22.7 0.3 0.2 1PSOP9 21.5 -0.9 -0.8 EQWWGJ 22.7 0.3 0.2 2BSDEQ 21.6 -0.8 -0.7 AOZMSG 22.7 0.3 0.2 F9BYIQ 21.6 -0.8 -0.7 QRDRJ1 22.7 0.3 0.2 SV4SBQ 21.6 -0.8 -0.7 MSFAND 22.7 0.3 0.2 N8BKMB 21.7 -0.7 -0.6 7S7SS2 22.8 0.4 0.3 AAPSTZ 21.8 -0.6 -0.6 8828D8 22.8 0.4 0.3 QJJYGQ 21.8 -0.6 -0.6 ICZF4Z 22.9 0.5 0.3 HHDUPI 21.8 -0.6 -0.6 5W5519 22.9 0.5 0.4 WEJJEJ 21.8 -0.6 -0.6 OLWSRI 22.9 0.5 0.4 TELOLF 21.8 -0.6 -0.5 8XQEGQ 22.9 0.5 0.4 U3WKHW 21.9 -0.5 -0.5 8TKCKC 22.9 0.5 0.4 9QNQPB 21.9 -0.5 -0.5 KHGLHU 22.9 0.5 0.4 C9QQGT 21.9 -0.5 -0.5 QPXWKT 23.0 0.6 0.4 GKMCN5 21.9 -0.5 -0.5 NPEUNW 23.0 0.6 0.4 VBO7OP 22.0 -0.4 -0.4 Y68SYY 23.0 0.6 0.4 YS66H6 22.0 -0.4 -0.4 BAYSRL 23.0 0.6 0.4 AIW1Z2 22.0 -0.4 -0.4 55IZ55 23.0 0.6 0.4 SUSSDP 22.0 -0.4 -0.4 CLRNDG 23.0 0.6 0.4 9WFUHI 22.0 -0.4 -0.4 MSHBVG 23.0 0.6 0.4 HPIHHH 22.0 -0.4 -0.4 QBF6VQ 23.0 0.6 0.4

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Scores for Test Sample 1

Cocaine Deviation Code Concentration from robust z-score (mass%) average RDRW1X 23.0 0.6 0.5 1IIEIC 23.0 0.6 0.5 WV88U8 23.1 0.7 0.5 OB929H 23.1 0.7 0.5 RPI8GV 23.1 0.7 0.5 7Z33IM 23.1 0.7 0.6 8288I1 23.2 0.8 0.6 PCYCJC 23.2 0.8 0.6 555HC5 23.3 0.9 0.7 RCBIBN 23.3 0.9 0.7 SYLJNC 23.4 1.0 0.8 YQXDTM 23.8 1.4 1.1 K9O99N 24.0 1.6 1.3 9DKDUD 24.0 1.6 1.3 ECOCCC 24.1 1.7 1.4 WPE9JA 24.2 1.8 1.5 4EF44P 24.3 1.9 1.5 CTRBHS 24.4 2.0 1.6 YYONQA 24.5 2.1 1.7 SYYY0F 24.8 2.4 2.0 KOQ1NC 24.9 2.5 2.0 9LZ9YA 25.0 2.6 2.1 CELGEE 25.0 2.6 2.1 HDYYZY 25.7 3.3 2.7 2P2PU2 25.8 3.4 2.7 CPBBXT 26.0 3.6 3.0 22YK4V 26.0 3.6 3.0 PM7GBZ 26.2 3.8 3.1 LC7LMZ 26.5 4.1 3.4 R2YIAE 26.6 4.2 3.4 02OWVV 28.7 6.3 5.2 7JGGMW 31.0 8.6 7.1 HRZZZ0 31.3 8.9 7.4 NVWID3 36.8 14.4 12.0 64UHPY 38.2 15.8 13.2 PUTLIT 38.9 16.5 13.8 4QMQQQ 52.0 29.6 24.7 BSWNB0 52.6 30.2 25.2 JDZDJJ 59.0 36.6 30.5

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Sample 2 Analysis

Identified substances for Test Sample 2

Code Identified Substances 006FMT MDPV 02OWVV 3,4-methylendioxypyrovalerona 07RNYQ MDPV 0O73XC MPDV, 3,4 METHYLENEDIOXYPYROVALERONE 14YQYB MDPV 1IIEIC MDPV 1KOSTW 3,4-MDPV 1PSOP9 3,4 - methylenedioxypyrovalerone HCl ( MDPV HCl) 222A22 MDPV 22YK4V 3,4 mdpv 2333DY MDPV 2BSDEQ MDPV 2P2PU2 MDPV (3,4-Methylenedioxypyrovalerone) 31933H MDPV 33Q3N2 Methyledioxypyrovalerone (MDPV) 3CUTP4 MDPV 3EOHEE 3,4 MDPV 44N4AK MDPV 49LF34 MDPV 4EF44P MDPV 4FMLRF 3,4-MDPV 4ITTTE 3,4-MDPV 4QMQQQ MDPV 4STTTT MDPV 555HC5 3,4 -methylenedioxypyrovalerone (MDPV) 55IZ55 MDPV 5BOT5R 3,4 MDPV 5W5519 MDPV (3,4-Methylenedioxypyrovalerone) 60XF00 3,4 Methylenedioxypyrovalerone HCl 64UHPY MDPV 6C7TVN MDPV 7HN7A7 MDPV 7JGGMW MDPV 7S7SS2 3,4-Methylenedioxypyrovalerone 7ULAFF 3,4-Methylenedioxypyrovalerone (MDPV) 7UN77R Methylenedioxypyrovalerone (MDPV) 7Z33IM 3,4-Methylenedioxypyrovalerone 8288I1 3,4-Methylenedioxypyrovalerone - Lactose 8828D8 3,4-Methylenedioxypyrovalerone 8TKCKC 3,4-MPDV chlorhydrate

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code Identified Substances 8XQEGQ Methylendioxypyrovalerone(MDPV) 9CKOOD 3,4-Methylenedioxypyrovalerone 9DKDUD MDPV 9LZ9YA 3,4-MDPV 9N8FTT 3,4-Methylenedioxypyrovalerone 9ONAKN 3-4-Methylenedioxypyrovalerone 9QNQPB 3,4Methylenedioxypyrovalerone 9WFUHI Methylenedioxypyrovalerone (MDPV) 9YN990 3,4-Methylenedioxypyrovalerone A8R888 MDPV AAPSTZ MDPV ADPI7V MDPV AEFKAT MDPV AGJ544 MDPV AIQBL5 MDPV AIW1Z2 3,4-Methylenedioxypyrovalerone ANAAAW 3,4-Methylenedioxypyrovalerone (MDPV) AOZMSG 3,4-METHYLENEDIOXYPYROVALERONE (MDPV) BEXBRB MDPV BLBOCB Methyledioxypyrovalerone Hydrochloride BUHHL2 MDPV BZZZIR 3,4–Methylenedioxypyrovalerone (MDPV) C9QQGT Methylenedioxypyrovalerone (MDPV) and Lactose CELGEE alpha-PVP CLRNDG 3,4-methylenedioxypyrovalerone CMZFLS METHYLENEDIOXY-PYROVALERONE (MDPV) CPBBXT 3,4-Methylenedioxypyrovalerone CTRBHS Methylenedioxypyrovalerone (MDPV). D3UIUC 3,4-MDPV DIIBXI Methylenedioxypyrovalerone DPAIVA MDPV DYZ53I MDPV ECOCCC MDPV EDHZTN Methylenedioxypyrovalerone EQWWGJ 3,4-MDPV ESWD79 MDPV F0000S Methylendioxypyrovalerone (MDPV) F9BYIQ 3,4-Methylenedioxypyrovalerone FD4JOW 3,4-Methylenedioxypyrovalerone FPTIMV Test sample 2018/2/SM-2 contains Methylendioxypyrovalerone (MDPV) GCFWS5 MDPV GF7VNQ 3,4-Methylenedioxypyrovalerone (MDPV) GFFGAC 3,4 MDPV GKMCN5 3,4-Methylenedioxypyrovalerone

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code Identified Substances GU6GGK MDPV H6MPDC 3,4 - MDPV + LACTOSE H8G1O8 3,4 MDPV HATVYH Clorhidrato de 3,4-Metilendioxipirovalerona HDYYZY MDPV HEVEPB MDPV and Lactose HGGHOG 3,4 Methylenedioxypyrovalerone HHDUPI MDPV HI4WNN 3,4-MDPV HPIHHH MDPV HRFHJD Methylenedixypyrovalerone HRZZZ0 3,4-Methylenedioxypyrovalerone ICZF4Z 3,4-Methylenedioxypyrovalerone IL7F1S 3,4-MDPV IODUOV MDPV IXI4IQ MDPV JDZDJJ MDPV JXQBZB 3,4 Methylenedioxypyrovalerone K59V35 MDPV (methylenedioxypyrovalerone) K9O99N MDPV HCl KHGLHU 3,4-Methylenedioxypyrovalerone KILSPH MDPV KOQ1NC MDPV KSIKUP pyrovalerone KUVU4U 3,4-methylenedixypyrovalerone (MDPV) L9LV6L 3,4 Methylenedioxypyrovalerone LC7LMZ 3,4-MDPV LLTO7L MDPV, lactose LTTTTQ 3,4-methylenedioxypyrovalerone (MDPV) MFE65O 3,4-Methylenedioxypyrovalerone + lactose MJMMJM 3,4-MDPV MR1LVU Methylenedioxypyrovalerone (MDPV) MSFAND MDPV MSHBVG 3-4 3,4-Methylenedioxypyrovalerone N8BKMB methylenedioxypyrovalerone NAK5A7 3,4-METHYLENEDIOXYPYROVALERONE NCCCCR 3,4-Methylenedioxypyrovalerone NPEUNW 3,4-Methylenedioxypyrovalerone NSALLN MDPV OB929H MDPV OKBALQ 3,4-Methylenedioxypyrovalerone OLWSRI 3,4-Methylen edioxypyrovalerone ORPCAT MDPV PCYCJC MDPV

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code Identified Substances PM7GBZ 3,4-Methylenedioxypyrovalerone (MDPV) PMDM1U MDPV PMR0Q7 methyledioxypyrovalerona (MDPV) PQIKKZ MDPV PUTLIT 3,4-Methylenedioxypyrovalerone QBF6VQ MDPV QJJYGQ MDPV QJOV22 3,4-Methylenedioxypyrovalerone QMQ1QP 3,4-MDPV QORSXL 3,4-MDPV QPXWKT 3,4-methylenedioxypyrovalerone (MDPV) QRCK2V 3,4-Methylenedioxypyrovalerone QRDRJ1 Methylenedioxypyrovalerone (MDPV) + Lactose QTQQQ1 MDPV R2YIAE Methyledioxypyrovalerone and lactose R7GREQ 3,4-Methylenedioxypyrovalerone RCBIBN MDPV RDRW1X 3,4-Methylenedioxypyrovalerone RPI8GV Methylenedixypyrovalerone (MDPV) RRFXUO MDPV S919AS 3,4 Methylenedioxy pyrovalerone SBKWJS MDPV SHIGZS 3,4-Methylenedioxypyrovalerone, lactose SRCKGX MDPV SUSSDP MDPV SV4SBQ 3,4-Methylenedioxypyrovalerone (MDPV) SYLJNC 3,4-Methylenedioxypyrovalerone SYYY0F MDPV SZVWV9 mdpv T0PFVQ MDPV TELOLF MDPV U3WKHW 3,4-methylenedioxypyrovalerone U479HU 3,4-Methylenedioxypyrovalerone UHJIRN 3,4-methylenedioxypyrovalerone UNNSU8 Methyelenedioxypyrovalerone (MDPV) USULOL 3,4-Methylenedioxypyrovalerone UTTTWF 3,4-methylenedioxypirovalerone V4HVM5 3,4-Methylenedioxypyrovalerone VBO7OP Pyrovalerone W7K0RA it was not detected WEJJEJ MDPV HCl WMUWWC 3,4-methyl metilene dioxy pirovalerone WPE9JA DMPV WV88U8 3,4 MDPV

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Code Identified Substances WWWBLX Methylenedioxypyrovalerone (MDPV) XGLCLJ MDPV XLNP6X Pyrovalerone XUE0RE MDPV Y3XX1B MDPV Y68SYY METHYLEDIOXYPYROVALERONE (MDPV) YMK92M 3,4-methylendioxypyrovalerone YQELRV MDPV YQXDTM MDPV YS66H6 MDPV YSSSDR Pyrovalerone YYONQA MDPV Z00LTY MDPV Z7F75I NO DRUGS FOUND Z7JWAE Methlenedioxypyrovalerone ZJZZZ3 MDPV

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Statement of findings for Test Sample 2

Code 3,4- Methylenedioxypyr Lactose ovalerone 006FMT + + MARQUISE REAGENT: negative reaction, COBALT THIOCYANATE: negative reaction, GC-MS: MDPV (compared with library MS spectrum of MDPV), FTIR: MDPV (compared with IR spectrum of MDPV), FTIR: lactose (spectrum of ethanol ectract residue compared with IR spectrum of lactose) 02OWVV + - 3,4-methylendioxypyrovalerona identificado por GC/MS 07RNYQ + ANP Powder contains MDPV 0O73XC + + PRUEBA DE SCREENING: ZIMERMAN POSITIVO (AMARILLO), CRISTALES CARACTERISTICOS CON CLORURO DE MERCURIO, CROMATOGRAFIA EN CAPA FINA REVELADOR NINHIDRINA Rf CORRESPONDE (AZUL), FTIR ESPECTRO CORRESPONDE A MPDV BIBLIOTECA EQUIPO 14YQYB + ANP SM2 contains 16.96% MDPV. 1IIEIC + + This sample is MDPV. 1KOSTW + -

1PSOP9 + + 9,61 % MDPV base, laktose 222A22 + ANP

22YK4V + ANP comfirmed by gc msd 2333DY + + laktóz 2BSDEQ + + White powder containing 11.1%w/w MDPV and lactose 2P2PU2 + + Percentage of MDPV was 8.84 %. Additionally Lactose was identified. 31933H + +

33Q3N2 + ANP Item 2018/2/SM-2 found to contain Methyledioxypyrovalerone (MDPV). 3CUTP4 + + Lactose 3EOHEE + ANP 3,4 MDPV 3JJ2TA ANP ANP

44N4AK + +

49LF34 + + The test sample 2018/2/SM-2 contains 9.47 % m/m methylenedioxypyrovalerone (MDPV). 4EF44P + + LACTOSE

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Code 3,4- Methylenedioxypyr Lactose ovalerone 4FMLRF + + 3,4-MDPV in mixture with lactose 4ITTTE + + Also contains lactose 4QMQQQ + + MDPV was found in the sample 4STTTT + ANP METHYLENEDIOXYPYROVALERONE is controlled under the Misuse of Drugs Act 1971 (as amended) as a Class B drug, by virtue of the fact that it is a compound structurally derived from 2- amino-1-phenyl-1-propanone by substitution in the phenyl ring with an alkylenedioxy substituent; substitution at the 3-position with an alkyl substituent; and by inclusion of the nitrogen atom in a cyclic structure. 555HC5 + + 3,4 -methylenedioxypyrovalerone (MDPV) was identified by TLC and GC/MS ,quantified by GC. 55IZ55 + + MDPV was detected 5BOT5R + ANP

5W5519 + + LACTOSE 60XF00 + + Contain 3,4 Methylenedioxypyrovalerone 7.28% as base and Lactose (not Quantitated) 64UHPY + + Metildioxipirovalerona y lactosa 6C7TVN + + The test sample 2018/2/SM-2 was found to contain methylenedixypyrovalerone (MDPV) and lactose. 7HN7A7 + ANP In GCMS,we found MDPV peak. 7JGGMW + + MDPV + lactose 7P5A33 ANP ANP

7S7SS2 + + The sample contains 3,4-Methylenedioxypyrovalerone 7ULAFF + ANP Test sample 2018/2/SM-2 was confirmed to contain 3,4-Methylenedioxypyrovalerone (MDPV), a DEA schedule I substance. 7UN77R + + The sample 2018/2/SM-2 was found to contain 229 milligrams of a white powder. This powder was found to contain a mixture of methylenedioxypyrovalerone (MDPV) and lactose. 7Z33IM + ANP It include only 3,4-Methylenedioxypyrovalerone, We are not detected amount. Because There is not standart reference materials our laboratory now. 8288I1 + +

8828D8 + + The sample contains 3,4-methylenedioxypyrovalerone which is listed as a controlled drug according to french order, appendix IV of February 22nd 1990.

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Code 3,4- Methylenedioxypyr Lactose ovalerone 8TKCKC + + 3,4-MPDV chlorhydrate (9% as base) + lactose 8XQEGQ + + Lactose 9CKOOD + ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 17.1.. Methylenedioxypyrovalerone (MDPV) 9DKDUD + + Mdpv - Lactose 9LZ9YA + -

9N8FTT + + Mass spectrometry profile correlation between sample and reference material certified 9ONAKN + ANP SM-2 was found to contain 3,4-Methylenedioxypyrovalerone 9QNQPB + + lactose 9WFUHI + - The powder was analysed and found to contain Methylenedioxypyrovalerone (MDPV). Methylenedioxypyrovalerone (MDPV) is a compound structurally derived from 2-amino-1-phenyl-1- propanone by substitution in the phenyl ring with an alkylenedioxy substituent; substitution at the 3- position with an alkyl substituent; and by inclusion of the nitrogen atom in a cyclic structure, and as such is a class B controlled drug within the provisions of the Misuse of Drugs Act 1971. 9YN990 + ANP Sample SM-2 found to contain 3,4-Methylenedioxypyrovalerone. A8R888 + + SM 02 was found to contain Methylenedixypyrovalerone (MDPV) and lactose AAPSTZ + ANP

ADPI7V + + lactose AEFKAT + + The sample contains MDPV*HCl and Lactose, with 10.45% MDPV base AGJ544 + ANP

AIQBL5 + ANP

AIW1Z2 + ANP Controlled drug, MDPV, present in sample. Concentration approx 9% ANAAAW + + Sample 2018/2/SM-2 contains MDPV and lactose. MDPV was not quantified because our laboratory does not have reference standard. Tiocianate reaction was negative with this samples but Scott modificated reagent gives positive reaction. AOZMSG + -

BAYSRL + +

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Code 3,4- Methylenedioxypyr Lactose ovalerone BEXBRB + ANP Examination of sample SM-2 revealed the presence of 3,4-methylenedioxypyrovalerone BLBOCB + + the sample contains methyledioxypyrovalerone hydrochloride (10.3 +/- 0.1% as MDPV free base) and lactose BSWNB0 ANP ANP

BUHHL2 + ANP From confirmation test using (GC-MS), the sample was found to contain the controlled drug (MDPV). BZZZIR + ANP SM-2 contain 3,4–Methylenedioxypyrovalerone (MDPV) which is controlled under Malaysian Poisons Act 1952 C9QQGT + + Using the techniques CR, TLC, GC-MS and FT-IR sample was found to contain Methylenedioxypyrovalerone (MDPV) and Lactose CELGEE + ANP Sample tested positive for alpha-PVP. The substance was confirmed using GC-MS. No quantification was done as the substance is not included in the list of validated quantifiable substances in our laboratory. CLRNDG + +

CMZFLS + + B) One brown tinted glass container, labelled "2018/2/SM-2" "2, with attached black plastic lid that contained 216 milligrams of a white powder. This white powder was found to contain Methylenedioxypyrovalerone (MDPV). MDPV is a Class B drug under the provisions of the Misuse of Drugs Act 1971 (as amended). Lactose is not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). CPBBXT + + We found a mixture of 3,4-Methylenedioxypyrovalerone and lactose. CTRBHS + ANP This sample was found to contain Methylenedioxypyrovalerone (MDPV), which is a Class B controlled substance under the Misuse of Drugs Act 1971. D3UIUC + ANP The sample contain 3,4-MDPV DIIBXI + + Item 2018/2/SM-2 was found to contain one glass vial which held 223 milligrams of white powder. This powder contained METHYLENEDIOXYPYROVALERONE (MDPV). DPAIVA + + Lactose DYZ53I + +

ECOCCC + + SM2 contient de la MDPV avec du lactose EDHZTN + ANP One glass bottle containing 0.22 grammes of a powder containing 0.02 grammes of methylenedioxypyrovalerone, being a compound structurally derived from 2-amino-1-phenyl-1- propanone by substitution in the phenyl ring with an alkyenedioxy substituent and by substitution at the 3-position with an alkyl substituent and by inclusion of the nitrogen atom in a cyclic structure. EQWWGJ + ANP 3,4-MDPV was identified in the sample 2018/2/SM2

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Code 3,4- Methylenedioxypyr Lactose ovalerone ESWD79 + + Also it was found as a diluent: lactose. F0000S + ANP Methylendioxypyrovalerone (MDPV) is not controlled (scheduled) drug based on local (national) Law No.02/L-128 F9BYIQ + -

FD4JOW + + the sample contains 3,4-Methylenedioxypyrovalerone and Lactose FPTIMV + +

GCFWS5 + ANP NPS GF7VNQ + + Lactose is also present. GFFGAC + + WAS FOUND 3,4 MDPV AND LACTOSE GKMCN5 + ANP The sample was found to contain 3,4-methylenedioxypyrovalerone. GU6GGK + ANP

H6MPDC + + In relation to the 2018/2/SM-2 sample, a blue staining was observed when the SCOTT test was applied. A yellow color was observed when the MARQUIS test was applied, which presupposes the presence of 3.4-MDPV. He came to confirm that it was after the 3.4-DMPV after the application of TLc and Ftir. With FTIR, it was also possible to observe the presence of LACTOSE. H8G1O8 + + 3,4 MDPV is sheduled as illicit drug in France. HATVYH + + Lactosa HDYYZY + ANP

HEVEPB + + The Test sample 2018/2/SM-2 was analyzed by Thin Layer Chromatography technique and was found to contain MDPV and Lactose. HGGHOG + ANP

HHDUPI + ANP MDPV is the common name for methylenedioxyprovalerone, a Class B drug subject to the provisions of the Misuse of Drugs Act 1971 (amendment) order 2010. HI4WNN + ANP NPS HPIHHH + + lactose HRFHJD + + On analysis, I found the sample "SM-2" containing Methylenedixypyrovalerone and Lactose

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Code 3,4- Methylenedioxypyr Lactose ovalerone HRZZZ0 + ANP - HUAI9B + + The sample contained 3-4-Methylenedioxypyrovalerone (MDPV) and Lactose. ICZF4Z + + Also contain lactose. IL7F1S + + The sample contains 9,61±0,54 weight% 3,4-MDPV-base (3,4-methylenedioxypyrovalerone-base). The sample also contains lactose. IODUOV + ANP Powder containing MDPV IXI4IQ + ANP

JDZDJJ + +

JXQBZB + + 3,4 MDPV+ LACTOSE K59V35 + + 2018/2/SM-2 contains MDPV(methylenedioxypyrovalerone). It also contains lactose. K9O99N + + lactose KHGLHU + + 3,4-Methylenedioxypyrovalerone in lactose powder KILSPH + ANP White powder and odorless KOQ1NC + + new psychoactive substance KSIKUP + + pyrovalerone and lactose KUVU4U + + In the analisys was obteined (3,4-methylenedixypyrovalerone (MDPV)), which controled substance and lactose which is uncontroled substance for Colombia L9LV6L + ANP

LC7LMZ + + It has been detected the presence of 3,4-Methylenedioxypyrovalerone in the sample. LLTO7L + + This powder was found to contain MDPV together with the adulterant lactose LTTTTQ + ANP Sample 2018/2/SM-2 was found to contain 3,4-methylenedioxypyrovalerone (MDPV). MFE65O + + We analized the sample by FTIR and GC-MS. We could identify lactose by colourimetric test. The sample was analyze by GC-MS with differents solvents: Methanol, chloroform, ethanol and ethanol with internal standard. MJMMJM + - The sample contains 10,8% 3,4-MDPV

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Code 3,4- Methylenedioxypyr Lactose ovalerone MR1LVU + + Sample 2018/2/SM-2 contained Methylenedioxypyrovalerone (MDPV) together with the adulterant Lactose. Methylenedioxypyrovalerone (MDPV) is a Class B controlled drug under the provision of the Misuse of Drugs Act 1971 (as amended). Lactose is not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). MSFAND - - LACTOSE MSHBVG + + found sintetic cathynone 3,4-Methylenedioxypyrovalerone buth for lack of standard we cannot specify the purity % N8BKMB + ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule 1 17.1. Methylenedioxypyrovalerone (MDPV) NAK5A7 + ANP Sample 2018/2/SM-2 was found to contain 3,4-Methylenedioxypyrovalerone. NCCCCR + + SM-2 was contained 3,4-Methylenedioxypyrovalerone base.The test sample also contained lactose NPEUNW + + A composite was formed from 1 unit for testing of 1 unit received. 3,4-Methylenedioxypyrovalerone (salt form not determined) and lactose confirmed in the composite. NSALLN + ANP TEST SAMPLE 2018/2/SM -2 CONTAIN MDVP NVWID3 + + After chemical analysis was performed the sample was contained MDPV and Lactose. OB929H + ANP

OKBALQ + ANP

OLWSRI + ANP It include only 3,4-Methylenedioxypyrovalerone ORPCAT + + Table 1 Schedule 1, Narcotic substances (not used by medicine) PCYCJC + ANP MDPV is controlled by the Royal Decree of the 6th of september 2017 PM7GBZ + ANP The sample contains 3,4-Methylenedioxypyrovalerone (MDPV). Quantitation was not performed because of the luck of standard. PMDM1U + ANP White powder material that contains drug under international controle - MDPV. PMR0Q7 + + positive for illicit substance PQIKKZ + ANP

PUTLIT + ANP The sample contains 3,4-Methylenedioxypyrovalerone. QBF6VQ + ANP Lactose was found but the Communiqué 2018-086-CAL-QUI Report of uncontrolled substances and traces in Competency Tests indicate that sharp suttances are not reported or outside the scope of the procedures.

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Code 3,4- Methylenedioxypyr Lactose ovalerone QJJYGQ + + MDPV y Lactosa QJOV22 + ANP It include only 3,4-Methylenedioxypyrovalerone QMQ1QP + + The sample contains 3,4-MDPV and lactose as an adulterant. 3,4-MDPV is a cathinone derivative stimulant drug, one of the first designer drug emerged the NPS market. The substance is controlled in Poland. QORSXL + + 3,4-MDPV (8.5% ) and lactose QPXWKT + + Presence of 3,4-methylenedioxypyrovalerone hydrochloride and lactose was detected in the sample. The sample also contained multitude of trace level impurities. QRCK2V + + lactose QRDRJ1 + + In the 2018/2/SM-2 was proved the presence of Methylenedioxypyrovalerone (MDPV) and Lactose, with a quantification as base of 16.1% QTQQQ1 + ANP MDPV was detected by GC/MS and quantified by GC/FID R2YIAE + + Examination and analyses performed on the solid in SM-2 showed it to contain methyledioxypyrovalerone (a synthetic cathinone) and lactose R7GREQ + ANP 3,4-Methylenedioxypyrovalerone confirmed in SM-2. RCBIBN + + MDPV RDRW1X + ANP It include only 3,4-Methylenedioxypyrovalerone RPI8GV + + Identified by GCMS & LCMSMS technique and quantified by GC-FID technique. RRFXUO + + Sample contained MDPV as hydrochloride and LACTOSE. Identification of MDPV by FTIR and GC/MS, quantification by GC/FID. Identification of LACTOSE by FTIR and Colorimetric Reactions (Molish Test). S919AS + - 3,4 MDPV was found in GCMS analysis SBKWJS + + ./. SHIGZS + + The sample contains 3,4-Methylenedioxypyrovalerone which is scheduled as illicit drug in France. The lactose is not scheduled as illicit drug in France. It's a cutting agent. SRCKGX + + The sample contains MDPV (3,4-methylenedioxypyrovalerone). MDPV is a controlled substance in X. SUSSDP + -

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Code 3,4- Methylenedioxypyr Lactose ovalerone SV4SBQ + ANP Powder contains 3,4-Methylenedioxypyrovalerone (MDPV). Methylenedioxypyrovalerone (MDPV) is a controlled drug under the Misuse of Drugs Act 1977 to 2016. This is because MDPV is structurally derived from 2-amino-1-phenyl-1-propanone by substitution in the phenyl ring with an alkylenedioxy group and by substitution at the 3-position of the propanone side-chain with an alkyl substituent and by inclusion of the nitrogen atom in a cyclic structure. (See paragraph 1A(b) of Schedule 1 to the Misuse of Drugs (Amendment) Act, 2015). SYLJNC + ANP The sample contains 3,4-Methylenedioxypyrovalerone (not quantified) SYYY0F + + White powder containing MDPV SZVWV9 + +

T0PFVQ + - We detected MDPV in SM-2, but we are not able to give a quantitative result. TELOLF + + In the sample SM-2 there is a MDPV. MDPV is on the list of drugs. U3WKHW + - we can not quantify MDPV because we haven't got seized samples. U479HU + - 3,4-Methylenedioxypyrovalerone UHJIRN + - Not quantificated due to a lack of standard UNNSU8 + ANP Based on the above analysis, the sample was found to contain Methyelenedioxypyrovalerone (MDPV) USULOL + ANP Satisfied with result obtained UTTTWF + + 3,4-methylenedioxypirovalerone cut with lactose was identified V4HVM5 + + The sample contained 8.3% 3,4-MDPV and also lactose. VBO7OP + - Non addullterants. Only qualitative results W7K0RA ANP ANP in thin layer chromatography we could see the spot in SM-2 but because of we do not have all the drug standards we could not detect what was that? WEJJEJ + + Base MDPV 9.65% and lactose WMUWWC + - 3,4-methyl metilene dioxi pirovalerona WPE9JA + + DMPV was detected by GC/MS and quantified by GC/FID WV88U8 + + LACTOSE WWWBLX + ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 17.1. Methylenedioxypyrovalerone (MDPV)

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Code 3,4- Methylenedioxypyr Lactose ovalerone XGLCLJ + + The major compound we founded in sm-2 after GC/MS injection is MDPV XLNP6X - + Pyrovalerone and Lactose XUE0RE + + The sample contains 9.68 % of MDPV and also contains MDPPP Y3XX1B + + sample contains MDPV and lactose Y68SYY + ANP On analysis of a representative sample of the powder Methyledioxypyrovalerone was detected. YMK92M + ANP In the test simple 2018/2/SM-2 was detected 3,4 methylendioxypyrovalerone YQELRV + + The sample contains MDPV. The concentration has not been determined. YQXDTM + ANP White powder containing MDPV (not quantified) YS66H6 + ANP

YSSSDR + +

YYONQA + ANP White powder containing MDPV (8.8%w/w) wich is controlled by national law Z00LTY + ANP 2018/2/SM-2 has been detected containing 3,4-Methylenedioxypyrovalerone. Z7F75I - ANP

Z7JWAE + + The white powder was analysed and found to contain Methylenedioxypyrovalerone (MDPV). ZJZZZ3 + - MDPV and sugar are found due to our analysis during identification. But we hadn't got the reference material of MDPV and that's why we couldn't complete the quantification part.

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Identification methods for Test Sample 2

Legend : S ... used for Screening I ... used for Identification SI ... used for both

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Code 140 141 142 150 160 161 171 180 190 200 211 230 231 250 210 YYONQA I SI Z00LTY SI I Z7F75I S S S I I Z7JWAE S I I ZJZZZ3 SI I

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RESPONSE SUMMARY FOR TEST SAMPLE 2

Participants: 194

The response summary of all 194 participating laboratories for the identification of SM-2, frequency of use of screening and identification techniques and false positives and negatives:

Correct identification of Test Sample-2:

Substance Name Number of laboratories MDPV 184 Lactose 105

False positives for Test Sample-2:

Round Code Substance Reported Tech Code CELGEE alpha -PVP 180 KSIKUP Caffeine, Pyrovalerone 180, 190 0O73XC Ketamine 150, 190 VBO7OP Pyrovalerone 141, 171 WMUWWC Paracetamol 171, 180 XLNP6X Pyrovalerone 180, 190 YSSSDR Pyrovalerone 180

False negatives for Test Sample-2 with respect to MDPV (techniques(s) used):

Round Code Tech Code CELGEE 180 KSIKUP 180, 190 VBO7OP 141, 171 XLNP6X 180, 190 YSSSDR 180 Z7F75I 180

Analysis not performed for Test Sample-2 with respect to MDPV:

Round Code 3JJ2TA ANP 7P5A33 ANP BSWNB0 ANP W7K0RA ANP

Frequency of use of screening, identification and quantification techniques:

Response Summary Participants 194

Technique 140 141 142 150 160 161 171 180 190 200 210 211 230 231 250 Screening (No.) 66 74 65 20 2 4 8 70 17 1 2 0 1 0 4 (%) 34.0 38.1 33.5 10.3 1.0 2.1 4.1 36.1 8.8 0.5 1.0 0.0 0.5 0.0 2.1 Identification (No.) 21 11 10 39 6 16 27 178 85 3 10 2 3 5 4 (%) 10.8 5.7 5.2 20.1 3.1 8.2 13.9 91.8 43.8 1.5 5.2 1.0 1.5 2.6 2.1 Quantification (No.) 0 0 0 0 2 13 27 7 1 0 1 3 0 1 0 (%) 0.0 0.0 0.0 0.0 3.6 23.6 49.1 12.7 1.8 0.0 1.8 5.5 0.0 1.8 0.0

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Z-Score Report per Sample per Substance:

Round: 2018/2 Substance: SM-2; MDPV Robust average: 9.8% UNODC value: 9.8 %

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Z-Score Report per Sample per Substance:

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Z-Scores for Test Sample 2

MDPV MDPV Deviation Deviation Code Concentration from Code Concentration from z-score z-score (mass%) robust (mass%) robust average average 60XF00 7.3 -2.5 -2.6 UTTTWF 9.9 0.1 0.0 NPEUNW 8.0 -1.8 -1.9 RRFXUO 10.0 0.1 0.1 RPI8GV 8.0 -1.8 -1.9 HRZZZ0 10.0 0.2 0.1 V4HVM5 8.3 -1.5 -1.6 1IIEIC 10.0 0.2 0.1 07RNYQ 8.4 -1.4 -1.5 5W5519 10.0 0.2 0.1 QORSXL 8.5 -1.3 -1.4 PUTLIT 10.0 0.2 0.2 QMQ1QP 8.6 -1.2 -1.3 WV88U8 10.1 0.3 0.2 YYONQA 8.8 -1.0 -1.1 YSSSDR 10.1 0.3 0.2 A8R888 8.8 -1.0 -1.1 222A22 10.1 0.3 0.2 2P2PU2 8.8 -1.0 -1.0 31933H 10.2 0.4 0.4 8TKCKC 9.0 -0.8 -0.9 BLBOCB 10.3 0.5 0.4 QPXWKT 9.2 -0.7 -0.7 AIQBL5 10.4 0.6 0.5 NVWID3 9.3 -0.5 -0.6 ECOCCC 10.4 0.6 0.5 AIW1Z2 9.3 -0.5 -0.6 AEFKAT 10.5 0.6 0.6 555HC5 9.4 -0.4 -0.5 MJMMJM 10.8 1.0 0.9 HI4WNN 9.4 -0.4 -0.4 DPAIVA 11.0 1.2 1.1 49LF34 9.5 -0.3 -0.4 2BSDEQ 11.1 1.3 1.2 RCBIBN 9.5 -0.3 -0.4 LC7LMZ 11.1 1.3 1.2 EDHZTN 9.5 -0.3 -0.4 8XQEGQ 12.0 2.2 2.2 OB929H 9.6 -0.2 -0.3 HDYYZY 12.1 2.3 2.3 IL7F1S 9.6 -0.2 -0.3 HATVYH 12.3 2.5 2.5 1PSOP9 9.6 -0.2 -0.3 QRDRJ1 16.1 6.3 6.3 WEJJEJ 9.7 -0.2 -0.2 14YQYB 17.0 7.2 7.2 XUE0RE 9.7 -0.1 -0.2 JDZDJJ 24.0 14.2 14.3 WPE9JA 9.7 -0.1 -0.2 QTQQQ1 29.6 19.8 20.0 BAYSRL 9.7 -0.1 -0.2 4QMQQQ 38.0 28.2 28.5 SZVWV9 9.7 -0.1 -0.2 Y3XX1B 49.0 39.2 39.6 4FMLRF 9.8 0.0 -0.1

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Sample 3 Analysis

Identified substances for Test Sample 3

Code Identified Substances 006FMT Metamfetamine 07RNYQ Methamphetamine 0O73XC METAMFETAMINA 14YQYB Methaphetamine 1IIEIC Methamphetamine. 1KOSTW Methamphetamine 1PSOP9 Metamfetamine HCl 222A22 metamphetamine 22YK4V methampetamine 2333DY methamphetamine 2BSDEQ metamphetamine 2P2PU2 Methamphetamine 31933H metamphetamine 33Q3N2 Metamfetamine 3CUTP4 Metamphetamine 3EOHEE METAMPHETAMINE 3JJ2TA METAMFETAMINE 44N4AK metamfetamine 49LF34 Metamfetamine 4EF44P Metamfetamine 4FMLRF Metamfetamine 4ITTTE Metamphetamine 4QMQQQ Methamphetamine 4STTTT Methylamphetamine 555HC5 Methamfetamine 55IZ55 Metamphetamine 5BOT5R Metamfetamine 5W5519 METAMPHETAMINE 60XF00 Methamphetamine HCl 64UHPY Metanfetamina 6C7TVN Methamfetamine 7HN7A7 Methamphetamine 7JGGMW methamphetamine 7P5A33 MDEA 7S7SS2 Metamfetamine 7ULAFF Methamphetamine 7UN77R Methylamphetamine Hydrochloride 7Z33IM Metamfetamine 8288I1 Metamfetamine, Lactose 8828D8 Metamfetamine

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Code Identified Substances 8TKCKC metamfetamine chlorhydrate 8XQEGQ Methamphetamine 9CKOOD Methamphetamine 9DKDUD Metamfetamine 9LZ9YA metamphetamine 9N8FTT Metamfetamine 9ONAKN Methamphetamine 9QNQPB Methamphetamine 9WFUHI Methylamphetamine 9YN990 Methamphetamine A8R888 Metamfetamine AAPSTZ methamphetamine ADPI7V metamfetamine AEFKAT Methamphetamine AGJ544 Metanfetamine AIQBL5 Metanfetamine AIW1Z2 Metamfetamine ANAAAW Methamphetamine AOZMSG METAMFETAMINE 20.2 % BEXBRB Methamphetamine BLBOCB Methamphetamine Hydrochloride BUHHL2 Methamphetamine BZZZIR Methamphetamine C9QQGT Methamphetamine CELGEE Methamphetamine CLRNDG methamphetamine CMZFLS METHYLAMPHETAMINE HYDROCHLORIDE CPBBXT Metamfetamine CTRBHS Methamphetamine. D3UIUC Metamphetamine DIIBXI Methylamphetamine hydrochloride DPAIVA METAMPHETAMINE DYZ53I Methaphetamine hydrochloride ECOCCC METHAMPHETAMINE EDHZTN Methamphetamine EQWWGJ Methamphetamine ESWD79 Metamfetamine F0000S Methamphetamine F9BYIQ Metamfetamine FD4JOW Metamfetamine FPTIMV Test sample 2018/2/SM-3 contains Metamfetamine GCFWS5 metamfetamine GF7VNQ Metamfetamine GFFGAC METHANPHETAMINE

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Code Identified Substances GKMCN5 Methamphetamine GU6GGK Metanphetamine H6MPDC D- Methanphetamine +LACTOSE H8G1O8 Methamphetamine HATVYH Clorhidrato de Levo-Metanfetamina HDYYZY MA HEVEPB Metamfetamine and Lactose HGGHOG Metamfetamine HHDUPI Methylamphetamine HI4WNN Metamphetamine HPIHHH Metamfetamine hcl HRFHJD Metamfetamine HRZZZ0 Metamfetamine HUAI9B Methamphetamine ICZF4Z Metamfetamine IL7F1S metamfetamine IODUOV Methamphetamine IXI4IQ Methanfetamine JDZDJJ Méthamphétamine JXQBZB METAMFETAMINE K59V35 Methamphetamine K9O99N metamphetamine HCl KHGLHU Metamfetamine KILSPH Methamphetamine KOQ1NC Methamphetamine KSIKUP Metamphetamine KUVU4U Metamfetamine L9LV6L Methamphetamine LC7LMZ Metamfetamine LLTO7L Methylamphetamine, lactose LTTTTQ Metamfetamine MFE65O Metamfetamine + lactose MJMMJM methamphetamine MR1LVU Methylamphetamine Hydrochloride MSFAND METAMFETAMINE MSHBVG Metamfetamine N8BKMB methamphetamine NAK5A7 METHAMPHETAMINE NCCCCR Metamfetamine NPEUNW Methamphetamine NSALLN METANFETAMINE NVWID3 Amfetamine OB929H metanfetamina OKBALQ Metamfetamine

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Code Identified Substances OLWSRI Metamfetamine ORPCAT Methamphetamine PCYCJC metamphetamine PM7GBZ Methamphetamine PMDM1U METHAMPHETAMINE PMR0Q7 metaphetamine PQIKKZ metamfetamine PUTLIT Metamfetamine QBF6VQ Metamphetamine QJJYGQ Metanfetamina QJOV22 Metamfetamine QMQ1QP Metamfetamine QORSXL Methamphetamine QPXWKT Metamphetamine QRCK2V metamphetamine QRDRJ1 Metamfetamine + Lactose QTQQQ1 metamfetamine R2YIAE Metamfetamine R7GREQ Methamphetamine RCBIBN metamphetamine RDRW1X Metamfetamine RPI8GV Metamfetamine RRFXUO Metamfetamine S919AS Methamphetamine SBKWJS METAMFETAMINE SHIGZS Metamfetamine, lactose SRCKGX Methamphetamine SUSSDP Methamphetamine SV4SBQ Methylamphetamine SYLJNC Metamfetamine SYYY0F metamfetamine SZVWV9 metamphetamine T0PFVQ Metamphetamine TELOLF metamphetamine U3WKHW Methamphetamine U479HU Methamphetamine UHJIRN metamfetamine UNNSU8 Metamfetamine USULOL Metamfetamine UTTTWF metamfetamine V4HVM5 Methamphetamine VBO7OP methamphetamine W7K0RA metamfetamine WEJJEJ Metamphetamine HCl

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Code Identified Substances WMUWWC MDMA, metanfetamina WPE9JA metamphetamine WV88U8 METAMPHETAMINE WWWBLX Methamphetamine XGLCLJ Methamphetamine, dimethylamphetamine, N-Formylamphetamine XLNP6X Metamfetamine XUE0RE Methamphetamine Y3XX1B metamfetamine Y68SYY METHAMPHETAMINE YMK92M methamphetamine YQELRV metamphetamine YQXDTM methamphetamine YS66H6 metamfetamine YSSSDR Metamfetamine YYONQA metamfetamine Z00LTY Methamphetamine Z7F75I AMPHETAMINIC DERIVATIVES Z7JWAE Methamphetamine ZJZZZ3 Metamphetamine

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Statement of findings for Test Sample 3

Code Lactose Metamfetamine 006FMT + + MARQUISE REAGENT: positive result, COBALT THIOCYANATE: negative result, GC-MS: metamfetamine (compared with library MS spectrum of metamfetamine), FTIR: metamfetamine (compare with IR spectrum of metamfetamine), FTIR: lactose (spectrum of ethanol ectract residue compared with IR spectrum of lactose) 02OWVV - - no se pudo determinar por ningún método 07RNYQ ANP + Powder contains metahamphetamine - 17,92 % as base 0O73XC + + SCREENING: REACTIVO DE MARQUIS POSITIVO, REACCION DE ZIMON COLOR AZUL DIFERENCIA DE LA ANFETAMINA, CROMATOGRAFIA EN CAPA FINA Rf CORRESPONDE REVELADOR NINHIDRINA, FTIR ESPECTRO CORRESPONDE A METAMFETAMINA BIBLIOTECA EQUIPO 14YQYB ANP + SM3 contains 40.1% methamphetamine 1IIEIC + + This sample is methamphetamine. 1KOSTW - +

1PSOP9 + + 19,21 % metamfetamine base, laktose 222A22 ANP +

22YK4V ANP + confirmed by gc msd 2333DY + + laktóz 2BSDEQ + + White powder containing 20.0%w/w metamphetamine and lactose 2P2PU2 + + Percentage was 20.5 %. Additionally lactose was identified. 31933H + +

33Q3N2 ANP + Item 2018/2/SM-3 found to contain Metamfetamine. 3CUTP4 + + Lactose 3EOHEE ANP + METAMPHETAMINE 3JJ2TA ANP + We can´t cuantified due to we havent reference pattern 44N4AK + +

49LF34 + + The test sample 2018/2/SM-3 contains 19.54 % m/m metamfetamine. 4EF44P + + LACTOSE

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Code Lactose Metamfetamine 4FMLRF + + Metamfetamine in mixture with lactose 4ITTTE + + Also contains lactose 4QMQQQ + + Methamphetamine was found in the sample 4STTTT ANP + Methylamphetamine controlled by the Misuse of Drugs Act 1971 (as amended) as a Class A drug. 555HC5 + + Methamfetamine was identified by TLC and GC/MS ,quantified by GC. 55IZ55 + + Metamphetamin was detected 5BOT5R ANP +

5W5519 + + LACTOSE 60XF00 - + Contain Methamphetamine 19.72% as base 64UHPY + - Metanafetamina y lactosa 6C7TVN + + The test sample 2018/2/SM-3 was found to contain metamfetamine and lactose. 7HN7A7 ANP + In marquis test,we found blue color.We confirm with TLC and GCMS. 7JGGMW - +

7P5A33 ANP -

7S7SS2 + + The sample contains Metamfetamine 7ULAFF ANP + Test sample 201/2/SM-3 was confirmed to contain methamphetamine, a DEA schedule II substance. 7UN77R + + The sample 2018/2/SM-3 was found to contain 225 milligrams of a white powder. This powder was found to contain a mixture of methylamphetamine hydrochlorise and lactose. The purity of methylamphetamine was found to be 24% calculated as salt form. 7Z33IM ANP + It include only Metamfetamine 8288I1 + +

8828D8 + + The sample contains metamfetamine which is listed as a controlled drug according to french order, appendix III of February 22nd 1990. 8TKCKC + + metamfetamine chlorhydrate (15,8% as base) + lactose 8XQEGQ + + Lactose

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Code Lactose Metamfetamine 9CKOOD ANP + The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 18. methamphetamine (N,a -dimethylbenzeneethanamine) calculated as the hydrochloride 24% (w/w) 9DKDUD + + Metamfetamine 19% base - Lactose 9LZ9YA - +

9N8FTT + + Mass spectrometry profile correlation between sample and reference material certified 9ONAKN ANP + SM-3 was found to contain 19.4% Methamphetamine 9QNQPB + + lactose 9WFUHI - + The powder was analysed and found to contain Methylamphetamine. Methylamphetamine is a class A controlled drug within the provisions of the Misuse of Drugs Act 1971. 9YN990 ANP + Sample SM-3 found to contain Methamphetamine. A8R888 + + SM 03 was found to contain Metamfetamine and lactose AAPSTZ ANP +

ADPI7V + + lactose AEFKAT + + The sample contains Methamphetamine*HCl and Lactose, with 17.80% Methamphetamine base AGJ544 ANP +

AIQBL5 ANP +

AIW1Z2 ANP + Controlled drug, Metamfetamine, present in sample. Concentration approx 20% ANAAAW + + Sample 2018/2/SM-3 contains methamphetamine and lactose. Methamphetamine base concentration is (15,2 ± 0,8) %. AOZMSG - +

BAYSRL + +

BEXBRB ANP + Examination of sample SM-3 revealed the presence the metamphetamine BLBOCB + + the sample contains methamphetamine hydrochloride (19.8 +/- 0.4% as methamphetamine free base) and lactose BSWNB0 ANP ANP

BUHHL2 ANP + From screening test using (MR) and from confirmation test using (GC-MS), the sample was found to contain the controlled drug (Methamhetamine).

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Code Lactose Metamfetamine BZZZIR ANP + SM-3 contain Methamphetamine which is controlled under Malaysian Dangerous Drug Act 1952 C9QQGT + + Using the techniques CR, TLC, GC-MS and FT-IR sample was found to contain Methamphetamine and Lactose CELGEE ANP + Sample tested positive for Methamphetamine. The substance was confirmed using GC-MS. No quantification was done as the substance is not included in the list of validated quantifiable substances in our laboratory. CLRNDG + + Sample contains %19,7 methamphetamine. CMZFLS + + C) One brown tinted glass container, labelled "2018/2/SM-3" "5, with attached black plastic lid that contained 211 milligrams of a white powder. This white powder was found to contain Methylamphetamine Hydrochloride at an average purity of 22% in the salt form. Methylamphetamine Hydrochloride is a Class A drug under the provisions of the Misuse of Drugs Act 1971 (as amended). Lactose is not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). CPBBXT + + We found a mixture of Metamfetamine and lactose. The concentration of Metamfetamine is 30.5% w/w. CTRBHS ANP + This sample was found to contain Methamphetamine, which is a Class A controlled substance under the Misuse of Drugs Act 1971. D3UIUC ANP + The sample contain methamphetamine DIIBXI + + Item 2018/2/SM-3 was found to contain one glass vial which held 227 milligrams of white powder. This powder contained an average of 24% METHYLAMPHETAMINE HYDROCHLORIDE. DPAIVA + + lactose DYZ53I + +

ECOCCC + + SM3 contient de la METHAMPHETAMINE avec du lactose EDHZTN ANP + One glass bottle containing 0.19 grammes of a powder containing 0.03 grammes of methamphetamine. EQWWGJ ANP + Methamphetamine was identified in the sample 2018/2/SM3 ESWD79 + + Also it was found as a diluent: lactose. F0000S ANP + No F9BYIQ - +

FD4JOW + + the sample contains Metamfetamine and Lactose FPTIMV + +

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Code Lactose Metamfetamine GCFWS5 ANP + +caffeine GF7VNQ + + Lactose is also present. GFFGAC + + WAS FOUND METHANPHETAMINE AND LACTOSE GKMCN5 ANP + The sample was found to contain 19.4% of methamphetamine (as base). GU6GGK ANP +

H6MPDC + + Regarding the sample 2018/2/SM-3, a very slow blue color was observed when the SCOTT test was applied to the sample and an orange color after the application of the MARQUIS test, which presupposes the presence of menhanphetamine or its derivatives. What came to be confirmed after the completion of TLc and FTIR. With FTIR, it was also possible to observe the presence of LACTOSE. H8G1O8 + + Methamphetamine is sheduled as illicit drug in France. HATVYH + + Lactosa HDYYZY ANP +

HEVEPB + + The Test sample 2018/2/SM-3 was analyzed by Thin Layer Chromatography technique and was found to contain Metamfetamine and Lactose. HGGHOG ANP +

HHDUPI ANP + Methylamphetamine is a Class A drug subject to the provisions of the Misuse of Drugs Act 1971. HI4WNN ANP + Quite usual HPIHHH + + lactose HRFHJD + + On analysis, I found the sample "SM-3" containing Metamfetamine and Lactose HRZZZ0 ANP + - HUAI9B + + The sample contained 19.1% (w/w) Methamphetamine (base) Lactose also detected in the sample. ICZF4Z + + Also contain lactose. IL7F1S + + The sample contains19.9 ± 1.3 weight% metamfetamine-base. The sample also contains lactose. IODUOV ANP + Powder containing methamphetamine IXI4IQ ANP +

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Code Lactose Metamfetamine JDZDJJ + +

JXQBZB + + METAMFETAMINE + LACTOSE K59V35 + + 2018/2/SM-3 contains Methamphetamine. It also contains lactose. K9O99N + + lactose KHGLHU + + Metamfetamine in lactose powder KILSPH ANP + White powder and odorless KOQ1NC + +

KSIKUP - + Metamphetamine KUVU4U + + In the analisys was obteined (Metamfetamine), which controled substance and lactose which is uncontroled substance for Colombia L9LV6L ANP +

LC7LMZ + + It has been detected the presence of Metamfetamine in the sample. LLTO7L + + This powder was found to contain methylamphetamine together with the adulterant lactose LTTTTQ ANP + Sample 2018/2/SM-3 was found to contain 17.6% metamfetamine MFE65O + + The sample was analyze by GC-MS with differents solvents: Methanol, chloroform, ethanol and ethanol with internal standard. MJMMJM - + The sample contains 18,8% methamphetamine as free base MR1LVU + + Sample 2018/2/SM-3 contained Methylamphetamine Hydrochloride, at a concentration of 19% (calculated as base), together with the adulterant Lactose. Methylamphetamine Hydrochloride is a Class A controlled drug under the provision of the Misuse of Drugs Act 1971 (as amended). Lactose is not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). MSFAND - + LACTOSE MSHBVG + + found Metamfetamine with purity of 18% N8BKMB ANP + The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 18. Methamphetamine (N, a-dimethylbenzeneethanamine) calculated as the hydrochloride 22% (w/w) NAK5A7 ANP + Sample 2018/2/SM-3 was found to contain methamphetamine. NCCCCR + + SM-3 was contained Metamfetamine base.The test sample also contained lactose

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Code Lactose Metamfetamine NPEUNW + + A composite was formed from 1 unit for testing of 1 unit received. Methamphetamine hydrochloride and lactose confirmed in the composite. NSALLN ANP + TEST SAMPLE 2018/2/SM -3 CONTAIN METAMFETAMINE NVWID3 - + After chemical analysis was performed the sample was contained AMFETAMINE TYPE STIMULANTS. OB929H ANP +

OKBALQ ANP +

OLWSRI ANP + It include only Metamfetamine ORPCAT + + Table 2 Schedule 2, Psychotropic substances (used by medicine) PCYCJC ANP + metamphetamine is controlled by the Royal Decree of the 6th of september 2017 PM7GBZ ANP + The sample contains Methamphetamine hydrochloride. The purity of the sample is 20.36% as Methamphetamine base. PMDM1U ANP + White powder material that contains cdrug under international controle - METHAMPHETAMINE. PMR0Q7 + + positive for illicit substance PQIKKZ ANP +

PUTLIT ANP + The sample contains metamfetamine . QBF6VQ ANP +

QJJYGQ + + Metanfetamina y lactosa QJOV22 ANP + It include only Metamfetamine QMQ1QP + + The sample contains metamfetamine and lactose as an adulterant.The substance is controlled in Poland. QORSXL + + Methamphetamine (19.9%) and Lactose QPXWKT + + Presence of metamphetamine hydrochloride and lactose was detected in the sample. QRCK2V + + lactose QRDRJ1 + + In the 201/2/SM-3 was proved the presence of metamfetamine and Lactose. QTQQQ1 ANP + metamfetamine was detected by GC/MS and quantified by LC/MS/MS

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Code Lactose Metamfetamine R2YIAE - + Examination and analyses performed on the solid in SM-3 showed it to contain metamfetamine ( a central stimulant) R7GREQ ANP + Methamphetamine confirmed in SM-3 RCBIBN + + metamphetamine RDRW1X ANP + It include only Metamfetamine RPI8GV + + Identified by GCMS & LCMSMS technique and quantified by GC-FID technique. RRFXUO + + Sample contained Metanfetamine as hydrochloride and LACTOSE. Identification of Metanfetamine by FTIR and GC/MS, quantification by GC/FID. Identification of LACTOSE by FTIR and Colorimetric Reactions (MolishTest). S919AS - + Sample turned white to orange colour with Marquis test and methamphetamine was found in GCMS analysis SBKWJS + + ./. SHIGZS + + The sample contains Metamfetamine which is scheduled as illicit drug in France. The lactose is not scheduled as illicit drug in France. It's a cutting agent. SRCKGX + + The sample contains methamphetamine. The content of methamphetamine is determined to 25 % (as methamphetaminesulphate). Methamphetamine is a controlled substance in X. SUSSDP - +

SV4SBQ ANP + Powder contains Methylamphetamine (Metamfetamine). Methylamphetamine is a controlled drug under the Misuse of Drugs Acts, 1977 to 2016. SYLJNC ANP + The sample contains Metamfetamine (19.7%) SYYY0F + + White powder containing metamfetamine SZVWV9 + +

T0PFVQ - + We detected metamphetamine in SM-3, but we are not able to give a quantitative result. TELOLF + + In the sample SM-3 there is a metaphetamine. Metamphetamine is on the list of drugs. U3WKHW - + we can not quantify methamphetamine because we haven't got seized samples. U479HU - + Methamphetamine contain 19.12% UHJIRN - +

UNNSU8 ANP + Based on the above analysis, the sample was found to contain metamfetamine

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Code Lactose Metamfetamine USULOL ANP + Satisfied with result obtained UTTTWF + + Low amount of metamfetamine V4HVM5 + + The sample contained 19.2% of methamphetamine and and also lactose. VBO7OP - + Non addulterants W7K0RA ANP + we detected a spot in SM-3 with metamfetamine Rf in thin layer chromatography WEJJEJ + + Base Metamphetamine 18.57% and Lacose WMUWWC - + MDMA metanfetamina WPE9JA + + metamphetamine was detected by GC/MS and quantified by GC/FID WV88U8 + + LACTOSE WWWBLX ANP + The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 18. Methamphetamine (N, alpha-dimethylbenzeneethanamine) XGLCLJ + + The major compound we founded in sm-3 after GC/MS injection is dimethylamphetamine XLNP6X + + Metamfetamine and Lactose XUE0RE + + The sample contains 19.68 % of Methamphetamine Y3XX1B + + sample contains metamfetamine and lactose Y68SYY ANP + On analysis of a representative sample of the powder Methamphetamine was detected with a purity of approximately 24% (calculated as base). YMK92M ANP + In the test simple 2018/2/SM-3 was detected methamphetamine YQELRV + + The sample contains metamphetamine. The concentration has not been determined. YQXDTM ANP + White powder containing methamphetamine (19.0%w/w) YS66H6 ANP +

YSSSDR + +

YYONQA ANP + White powder containing metamfetamine(20.4%w/w) wich is controlled by national law Z00LTY ANP + 2018/2/SM-3 has been detected containing 17.4% of Methamphetamine. Z7F75I ANP + NO MORE FINDINGS

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Code Lactose Metamfetamine Z7JWAE + + The white powder was analysed and found to contain Methamphetamine. ZJZZZ3 - + Metamphetamine and sugar are found due to our analysis in the identification part. In the quantification part, the ratio of metaphetamine is calculated as 19.5%.

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Identification methods for Test Sample 3

Legend : S ... used for Screening I ... used for Identification SI ... used for both

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Code 140 141 142 150 160 161 171 180 190 200 211 230 231 250 210 YYONQA I SI Z00LTY SI I Z7F75I S S S I I Z7JWAE S I I ZJZZZ3 SI I

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RESPONSE SUMMARY FOR TEST SAMPLE 3

Participants: 194

The response summary of all 194 participating laboratories for the identification of SM-3, frequency of use of screening and identification techniques and false positives and negatives:

Correct identification of Test Sample-3:

Substance Name Number of laboratories Metamfetamine 191 Lactose 100

False positives for Test Sample-3:

Round Code Substance Reported Tech Code 64UHPY 3,4 -Methylenedioxymetamfetamine (MDMA) 140, 180 7P5A33 N-Ethyl -methylenedioxyamphetamine (MDEA) 140, 161

GCFWS5 Caffeine 150, 180

NVWID3 Amfetamine 180

0O73XC 3,4-Methylenedioxymetamfetamine (MDMA) 150, 190 WMUWWC 3,4-Methylenedioxymetamfetamine (MDMA) 171, 180 XGLCLJ Dimethylamphetamine, N-formylamphetamine 180

False negatives for Test Sample-3 with respect to Metamfetamine (techniques(s) used):

Round Code Tech Code

7P5A33 140, 161

02OWVV 180

Analysis not performed for Test Sample-3 with respect to Metamfetamine:

Round Code BSWNB0 ANP

Frequency of use of screening, identification and quantification techniques:

Response Summary Participants 194

Technique 140 141 142 150 160 161 171 180 190 200 210 211 230 231 250 Screening (No.) 66 74 65 20 2 4 8 70 17 1 2 0 1 0 4 (%) 34.0 38.1 33.5 10.3 1.0 2.1 4.1 36.1 8.8 0.5 1.0 0.0 0.5 0.0 2.1 Identification (No.) 21 11 10 39 6 16 27 178 85 3 10 2 3 5 4 (%) 10.8 5.7 5.2 20.1 3.1 8.2 13.9 91.8 43.8 1.5 5.2 1.0 1.5 2.6 2.1 Quantification (No.) 0 0 0 0 9 25 55 15 1 0 1 1 1 3 0 (%) 0.0 0.0 0.0 0.0 8.1 22.5 49.5 13.5 0.9 0.0 0.9 0.9 0.9 2.7 0.0

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Z-Score Report per Sample per Substance:

Round: 2018/2 Substance: SM-3; Metamfetamine Robust average: 19.3% UNODC value: 19.6 %

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Z-Score Report per Sample per Substance:

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Scores for Test Sample 3

Metamfetamine Metamfetamine Deviation Deviation Code Concentration from Code Concentration from z-score z-score (mass%) robust (mass%) robust average average F9BYIQ 3.9 -15.4 -13.6 GKMCN5 19.4 0.1 0.1 YSSSDR 6.8 -12.5 -11.1 9ONAKN 19.4 0.1 0.1 PUTLIT 11.6 -7.7 -6.8 ZJZZZ3 19.5 0.2 0.1 RDRW1X 14.5 -4.8 -4.3 5W5519 19.5 0.2 0.1 4STTTT 15.0 -4.3 -3.8 SZVWV9 19.5 0.2 0.1 8TKCKC 15.8 -3.5 -3.1 HPIHHH 19.5 0.2 0.1 4QMQQQ 16.0 -3.3 -3.0 49LF34 19.5 0.2 0.2 HDYYZY 16.2 -3.1 -2.8 UTTTWF 19.6 0.3 0.2 RPI8GV 17.0 -2.3 -2.1 WV88U8 19.6 0.3 0.3 QMQ1QP 17.2 -2.1 -1.9 DYZ53I 19.7 0.4 0.3 Z00LTY 17.4 -1.9 -1.7 XUE0RE 19.7 0.4 0.3 CMZFLS 17.5 -1.8 -1.6 SYLJNC 19.7 0.4 0.3 UHJIRN 17.6 -1.7 -1.5 CLRNDG 19.7 0.4 0.3 LTTTTQ 17.6 -1.7 -1.5 60XF00 19.7 0.4 0.3 AEFKAT 17.8 -1.5 -1.4 QRCK2V 19.8 0.5 0.4 07RNYQ 17.9 -1.4 -1.3 DPAIVA 19.8 0.5 0.4 YMK92M 18.0 -1.3 -1.2 BLBOCB 19.8 0.5 0.4 MSHBVG 18.0 -1.3 -1.2 FPTIMV 19.8 0.5 0.4 QJJYGQ 18.1 -1.2 -1.1 QORSXL 19.9 0.6 0.5 N8BKMB 18.1 -1.2 -1.1 IL7F1S 19.9 0.6 0.5 HATVYH 18.2 -1.1 -1.0 BZZZIR 19.9 0.6 0.5 ANAAAW 18.2 -1.1 -1.0 2BSDEQ 20.0 0.7 0.6 33Q3N2 18.4 -0.9 -0.8 AIW1Z2 20.0 0.7 0.6 TELOLF 18.5 -0.8 -0.8 3CUTP4 20.0 0.7 0.6 WPE9JA 18.5 -0.8 -0.7 55IZ55 20.0 0.7 0.6 WEJJEJ 18.6 -0.7 -0.7 9CKOOD 20.0 0.7 0.6 QTQQQ1 18.6 -0.7 -0.7 OLWSRI 20.0 0.7 0.6 RCBIBN 18.7 -0.6 -0.6 8XQEGQ 20.0 0.7 0.6 SRCKGX 18.7 -0.6 -0.6 9QNQPB 20.1 0.8 0.7 MJMMJM 18.8 -0.5 -0.5 HRZZZ0 20.2 0.9 0.7 1IIEIC 18.9 -0.4 -0.4 AOZMSG 20.2 0.9 0.8 8828D8 18.9 -0.4 -0.4 LC7LMZ 20.2 0.9 0.8 EDHZTN 18.9 -0.4 -0.4 PCYCJC 20.2 0.9 0.8 HRFHJD 18.9 -0.4 -0.4 RRFXUO 20.2 0.9 0.8 VBO7OP 18.9 -0.4 -0.4 PM7GBZ 20.4 1.1 0.9 YQXDTM 19.0 -0.3 -0.3 YYONQA 20.4 1.1 0.9 QPXWKT 19.0 -0.3 -0.3 USULOL 20.5 1.2 1.0 NPEUNW 19.0 -0.3 -0.3 2P2PU2 20.5 1.2 1.0 AIQBL5 19.0 -0.3 -0.3 QJOV22 20.5 1.2 1.0 LLTO7L 19.0 -0.3 -0.3 A8R888 20.9 1.6 1.4 HI4WNN 19.0 -0.3 -0.3 SHIGZS 21.0 1.7 1.5 K9O99N 19.0 -0.3 -0.3 GF7VNQ 21.4 2.1 1.8 MR1LVU 19.0 -0.3 -0.3 7Z33IM 21.9 2.6 2.2 9DKDUD 19.0 -0.3 -0.3 ECOCCC 22.1 2.8 2.4 31933H 19.0 -0.3 -0.3 AAPSTZ 22.2 2.9 2.6 KOQ1NC 19.1 -0.2 -0.2 Y3XX1B 23.2 3.9 3.4 HUAI9B 19.1 -0.2 -0.2 GU6GGK 23.4 4.1 3.6 4EF44P 19.1 -0.2 -0.2 Y68SYY 24.0 4.7 4.1 DIIBXI 19.1 -0.2 -0.2 IXI4IQ 25.2 5.9 5.2 U479HU 19.1 -0.2 -0.2 CPBBXT 30.5 11.2 9.9 7UN77R 19.1 -0.2 -0.2 JDZDJJ 33.0 13.7 12.1 V4HVM5 19.2 -0.1 -0.1 NVWID3 33.6 14.3 12.6 1PSOP9 19.2 -0.1 -0.1 14YQYB 40.1 20.8 18.3 BAYSRL 19.3 0.0 0.0 S919AS 41.9 22.6 19.9 4FMLRF 19.3 0.0 0.0 555HC5 58.6 39.3 34.7 KHGLHU 19.3 0.0 0.0

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Sample 4 Analysis

Identified substances for Test Sample 4

Code Identified Substances 006FMT Amfetamine 02OWVV cafeina 07RNYQ Amphetamine 0O73XC ANFETAMINA 14YQYB Amphetamine 1IIEIC Amphetamine 1KOSTW Amphetamine, Caffeine 1PSOP9 Amfetamine sulfate 222A22 amphetamine 22YK4V amphetamine 2333DY amphetamine 31933H amphetamine 33Q3N2 Amfetamine 3CUTP4 Amphetamine 3EOHEE AMPHETAMINE 3JJ2TA AMFETAMINE 44N4AK amfetamine 49LF34 Amfetamine 4EF44P AMFETAMINE 4FMLRF Amfetamine 4ITTTE amphetamine 4QMQQQ Amphetamine 4STTTT Amphetamine 555HC5 Amfetamine 55IZ55 Amphetamine 5BOT5R Amphetamine 5W5519 AMPHETAMINE 60XF00 Amphetamine Sulfate 64UHPY Anfetamina 6C7TVN Amfetamine 7HN7A7 Amphetamine and caffeine 7P5A33 Amfetamine 7S7SS2 Amfetamine 7ULAFF Amphetamine 7UN77R Amphetamine Sulphate 7Z33IM amfetamine 8288I1 Amfetamine 8828D8 Amfetamine 8TKCKC amfetamine sulfate 8XQEGQ Amphetamine

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Code Identified Substances 9CKOOD Amphetamine 9DKDUD amfetamine 9LZ9YA amphetamine 9N8FTT Amfetamine 9ONAKN Amphetamine 9QNQPB Amphetamine 9WFUHI Amphetamine 9YN990 Amphetamine A8R888 Amfetamine AAPSTZ amphetamine ADPI7V amfetamine AEFKAT Amphetamine AGJ544 amfetamine AIQBL5 Amfetamine AIW1Z2 Amfetamine ANAAAW Amphetamine AOZMSG AMFETAMINE 6.6 % AND CAFFEINE BEXBRB Amfetamine BLBOCB Amphetamine Sulfate BZZZIR Amphetamine and Caffeine C9QQGT Amphetamine, Caffeine and Lactose CELGEE Amphetamine CLRNDG amphetamine CMZFLS AMPHETAMINE CPBBXT Amfetamine CTRBHS Amphetamine. D3UIUC Amphetamine, caffeine DIIBXI Amphetamine DPAIVA AMPHETAMINE DYZ53I Amphetamine sulphate ECOCCC AMPHETAMINE EDHZTN Amfetamine EQWWGJ Amphetamine ESWD79 Amfetamine F0000S Amphetamine FD4JOW Amfetamine FPTIMV Test sample 2018/2/SM-4 contains Amfetamine + minor Metamfetamine GCFWS5 amfetamine GF7VNQ Amfetamine GFFGAC ANPHETAMINE GKMCN5 Amphetamine GU6GGK Amphetamine H6MPDC Amphetamine + COCAINE + LACTOSE H8G1O8 Amphetamine

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Code Identified Substances HATVYH Sulfato de Anfetamina HDYYZY A HEVEPB Amfetamine, Caffeine and Lactose HGGHOG Amfetamine HHDUPI Amphetamine HI4WNN Amphetamine + Caffeine HPIHHH amfetamine SO4 HRFHJD Amfetamine HRZZZ0 Amfetamine HUAI9B Amphetamine ICZF4Z Amfetamine IL7F1S amfetamine IODUOV Amphetamine IXI4IQ Amfetamine JXQBZB AMFETAMINE K59V35 Amphetamine K9O99N amphetamine sulphate KHGLHU Amfetamine KILSPH Amphetamine and Caffeine KOQ1NC amphetamine KSIKUP Amphetamine KUVU4U Amfetamine L9LV6L Amphetamine LC7LMZ amfetamine LLTO7L Amphetamine, Caffeine, Lactose LTTTTQ Amfetamine and caffeine MFE65O Amfetamine + lactose + caffeine MJMMJM amphetamine MR1LVU Amphetamine MSFAND AMFETAMINE MSHBVG Amfetamine N8BKMB Amphetamine NAK5A7 AMPHETAMINE NCCCCR Amfetamine NPEUNW Amphetamine NSALLN AMFETAMINE NVWID3 Amfetamine OB929H anfetamina OKBALQ Amfetamine OLWSRI amfetamine ORPCAT Amphetamine, Methamphetamine PCYCJC amphetamine PM7GBZ Amphetamine PMDM1U AMPHETAMINE

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Code Identified Substances PMR0Q7 amphetamine PQIKKZ amfetamine PUTLIT Amfetamine QBF6VQ Amphetamine QJOV22 Amfetamine QMQ1QP Amfetamine QORSXL Amphetamine QPXWKT Amphetamine QRCK2V amphetamine QRDRJ1 Amfetamine + Caffeine + Lactose QTQQQ1 amfetamine R2YIAE Amfetamine, caffeine and lactose R7GREQ Amphetamine & Caffeine RCBIBN amphetamine RDRW1X Amfetamine RPI8GV Amfetamine S919AS Amphetamine, Caffeine SBKWJS AMFETAMINE SHIGZS Amfetamine, caffeine, lactose SRCKGX Amphetamine SUSSDP Amphetamine SV4SBQ Amphetamine SYLJNC Amfetamine SYYY0F amfetamine SZVWV9 amphetamine T0PFVQ Amphetamine (+ caffeine) TELOLF amphetamine U3WKHW Amphetamine U479HU Amphetamine UHJIRN amfetamine UNNSU8 Amfetamine USULOL Amfetamine and Caffeine UTTTWF Amfetamine V4HVM5 Amphetamine VBO7OP Amphetamine W7K0RA amfetamine WEJJEJ Amphetamine sulphate WMUWWC anfetamina, cafeina WPE9JA amphetamine WV88U8 AMPHETAMINE WWWBLX Amphetamine XGLCLJ Amphetamine, Formetamide XLNP6X Caffeine XUE0RE Amphetamine

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Code Identified Substances Y3XX1B amfetamine Y68SYY AMPHETAMINE YMK92M amfetamine YQELRV Amphetamine YQXDTM N-methyliminopropylbenzene YSSSDR Amfetamine Z00LTY Amphetamine Z7F75I METHAMPHETAMINE Z7JWAE Amphetamine ZJZZZ3 Amphetamine

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Statement of findings for Test Sample 4

Code Amfetamine Caffeine Lactose 006FMT + + + MARQUISE REAGENT: positive result, COBALT THIOCYANATE: negative result, GC-MS: amfetamine (compared with library MS spectrum of amfetamine + retention time of reference substance), GC-MS: caffeine (compared with library MS spectrum of caffeine + retention time of reference substance), FTIR: amfetamine (compared with IR spectrum of amfetamine), FTIR: lactose (spectrum of ethanol extract residue compared with IR spectrum of lactose), precipitation reaction with BaCl2: sulfate anions, GC-FID: 9,33% amfetamine sulphate (6,81% amfetamine as base) 02OWVV - + - identificado por GC/Ms 07RNYQ + + ANP Powder contains amphetamine - 6.13 % as base 0O73XC + ANP + SCREENING: REACTIVO DE MARQUIS POSITIVO, REACCION DE SIMON COLOR ROSADO A ROJO DIFERENCIA DE LA METAMFETAMINA, CROMATOGRAFIA EN CAPA FINA Rf CORRESPONDE REVELADOR NINHIRRINA, FTIR ESPECTRO CORRESPONDE A ANFETAMINA BIBLIOTECA NO ENCONTRADO 14YQYB + - ANP SM4 contains 26.2% amphetamine 1IIEIC + + + This sample is amphetamine. 1KOSTW + + -

1PSOP9 + + + 6,28 % amfetamine base, laktose, caffeine 222A22 + + ANP + caffeine 22YK4V + + ANP this sample also contains caffeine 2333DY + + + koffein, laktóz 2BSDEQ - + + White powder containing caffeine and lactose 2P2PU2 - + + Caffeine and Lactose were identified. 31933H + + +

33Q3N2 + ANP ANP Item 2018/2/SM-4 found to contain amfetamine. 3CUTP4 + + + Lactose and Caffeine 3EOHEE + - ANP AMPHETAMINE 3JJ2TA + ANP ANP

44N4AK + + +

49LF34 + + + The test sample 2018/2/SM-4 contains 5.87 % m/m amfetamine.

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Code Amfetamine Caffeine Lactose 4EF44P + + + LACTOSE CAFEINE 4FMLRF + + + Amfetamine in mixture with lactose and caffeine 4ITTTE + + + Also contains lactose and coffeine 4QMQQQ + + - Amphetamine was found in the sample 4STTTT + + ANP Amphetamine is controlled by the Misuse of Drugs Act 1971 (as amended) as a Class B drug. 555HC5 + + + Amfetamine was identified by TLC and GC/MS ,quantified by GC. 55IZ55 + + + Amphetamine was detected 5BOT5R + + ANP

5W5519 + + + LACTOSE AND CAFFEIN 60XF00 + + - Contain Amphetamine 6.57% as base and Caffeine 64UHPY + + + anfetamina, cafeina y lactosa 6C7TVN + + - The test sample 2018/2/SM-4 was found to contain amfetamine and lactose. 7HN7A7 + + ANP In GCMS, we found Amphetamine and Caffeine peak. 7JGGMW - + + lactose 7P5A33 + ANP ANP

7S7SS2 + + + The sample contains Amfetamine and Caffeine 7ULAFF + + ANP Test sample 201/2/SM-4 was confirmed to contain amphetamine, a DEA schedule II substance. The sample was also found to contain caffeine. 7UN77R + + + The sample 2018/2/SM-4 was found to contain 228 milligrams of a white powder. This was found to contain a mixture of amphetamine sulphate, caffeine and lactose. The purity of the amphetamine was found to be 10% calculated as salt form. 7Z33IM + + ANP It includes Metamfetamine But it also includes low amounts Caffeine, My-Inositol and Mannitol by adulterants. It includes %2,8 caffeine 8288I1 + + +

8828D8 + + + The sample contains amfetamine which is listed as a controlled drug according to french order, appendix III of February 22nd 1990. 8TKCKC + + + amfetamine sulfate (no quantified) + lactose + cafeine

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Code Amfetamine Caffeine Lactose 8XQEGQ + + + Caffeine, Lactose 9CKOOD + ANP ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 19. (1) (ii) Amphetamine (a -methylbenzeneethanamine) 9DKDUD + + + amfetamine 7% base - caffeine, lactose 9LZ9YA + - - Also caffeine 9N8FTT + + + Mass spectrometry profile correlation between sample and reference material certified 9ONAKN + + ANP SM-4 was found to contain amphetamine and caffeine 9QNQPB + ANP + lactose 9WFUHI + - - The powder was analysed and found to contain Amphetamine. A further sample of the powder was analysed and found to contain 6% (weight for weight) Amphetamine. Amphetamine is a class B controlled drug within the provisions of the Misuse of Drugs Act 1971. 9YN990 + + ANP Sample SM-4 found to contain Amphetamine and Caffeine A8R888 + + + SM 04 was found to contain Amfetamine , caffeine and lactose AAPSTZ + + ANP and also we have found caffeine ADPI7V + + + lactose, coffeine AEFKAT + + + The sample contains Amphetamine sulfate, Caffeine and Lactose, with 7.17% Amphetamine base AGJ544 + + ANP Also contains caffein AIQBL5 + + ANP

AIW1Z2 + + ANP Controlled drug, Amfetamine, present in sample. Concentration approx 7. Other substance found is caffeine ANAAAW + + + Sample 2018/2/SM-4 contains amphetamine, caffeine and lactose. Amphetamine was not quantified because our laboratory does not have reference standard. AOZMSG + + -

BAYSRL + + +

BEXBRB + ANP ANP Examination of sample SM-4 revealed the presence the amfetamine BLBOCB + + + the sample contains amphetamine sulfate (7.1 +/- 0.2% as amphetamine free base), caffeine and lactose BSWNB0 ANP ANP ANP

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Code Amfetamine Caffeine Lactose BUHHL2 - + ANP From confirmation test using (GC-MS), the sample was found to contain the adulterant/diluent caffeine. BZZZIR + + ANP SM-4 contain Amphetamine which is controlled under Malaysian Dangerous Drug Act 1952 and Caffeine which is controlled under Malaysian Poisons Act 1952 C9QQGT + + + Using the techniques CR, TLC, GC-MS and FT-IR sample was found to contain Amphetamine, Caffeine and Lactose CELGEE + + ANP Sample tested positive for Amphetamine, Caffeine was also detected in the sample. The substances were confirmed using GC-MS.

No quantification was done as the substance is not included in the list of validated quantifiable substances in our laboratory. CLRNDG + + + Sample caontains %6,5 amphetamine CMZFLS + + + D) One brown tinted glass container, labelled "2018/2/SM-4" "5, with attached black plastic lid that contained 226 milligrams of a brown powder. This brown powder was found to contain Amphetamine at an average purity of 9% in the sulphate salt form. Amphetamine is a Class B drug under the provisions of the Misuse of Drugs Act 1971 (as amended). Caffeine and Lactose are not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). CPBBXT + + + We found a mixture of Amfetamine, Caffeine and lactose. CTRBHS + + ANP This sample was found to contain Amphetamine which is a Class B controlled substance under the Misuse of Drugs Act 1971. It was also found to contain Caffeine which is not controlled. D3UIUC + + ANP The sample contain amphetamine and caffeine DIIBXI + + + Item 2018/2/SM-4 was found to contain one glass vial which held 229 milligrams of white powder. This powder contained an average of 7% AMPHETAMINE. DPAIVA + + + CAFFEINE,LACTOSE DYZ53I + + +

ECOCCC + + + SM4 contient de l'AMPHETAMINE ,caféine avec du lactose EDHZTN + + + One glass bottle containing 0.22 grammes of a powder containing 0.01 grammes of amfetamine. EQWWGJ + + ANP The sample 2018/2/SM-4 was found to contain Amphetamine ESWD79 + + + Also it was found as a diluents: lactose and caffeine. F0000S + + ANP Amphetamine is mixed with Caffeine. F9BYIQ - + -

FD4JOW + + + the sample contains Amfetamine, Caffeine and Lactose

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Code Amfetamine Caffeine Lactose FPTIMV + + +

GCFWS5 + + ANP + caffeine GF7VNQ + + + Lactose and Caffeine are also present. GFFGAC + + + WAS FOUND ANPHETAMINE, LACTOSE AND CAFFEINE GKMCN5 + + ANP The sample was found to contain amphetamine. GU6GGK + + ANP

H6MPDC + - + With regard to the sample 2018/2/SM-4, no reaction was observed with the SCOTT test but when the MARQUIS test was applied, a light brown color was observed, which may indicate the presence of amphetamine or also cafeine. With regard to the sample 2018/2/SM-4, no reaction was observed with the SCOTT test but when the MARQUIS test was applied, a light brown color was observed, which may indicate the presence of amphetamine or also cafeine. With the application of TLC it was possible to observe the presence of amphetamine and with FTIR there was the presence of amphetamine and possibly cocaine.

H8G1O8 + + + Amphetamine is sheduled as illicit drug in France. HATVYH + + + Cafeina y Lactosa HDYYZY + ANP ANP

HEVEPB + + + The Test sample 2018/2/SM-4 was analyzed by Thin Layer Chromatography technique and was found to contain Amfetamine, Caffeine and Lactose. HGGHOG + - ANP

HHDUPI + - ANP Amphetamine is a Class B drug subject to the provisions of the Misuse of Drugs Act 1971. HI4WNN + + ANP Quite usual. Typical adulterant. HPIHHH + + + caffeine lactose HRFHJD + - + On analysis, I found the sample "SM-4" containing Amfetamine, Lactose and Caffeine HRZZZ0 + + ANP - HUAI9B + + + The sample contained Amphetamine. Lactose and Caffeine also detected in the sample. ICZF4Z + + + Also contain caffeine and lactose.

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Code Amfetamine Caffeine Lactose IL7F1S + + + The sample contains 6.43± 0.56 weight% amfetamine-base. The sample also contains caffeine and lactose. IODUOV + + ANP Powder containing amphetamine IXI4IQ + + ANP

JDZDJJ - - +

JXQBZB + + + AMFETAMINE + CAFFEINE+ LACTOSE K59V35 + + + 2018/2/SM-4 contains Amphetamine. It also contains lactose and caffeine. K9O99N + + + lactose, caffeine KHGLHU + + + Amfetamine, caffeine and lactose KILSPH + + ANP White powder and odorless KOQ1NC + + +

KSIKUP + + + Amphetamine and coffeine and lactose KUVU4U + + + In the analisys was obteined (Amfetamine), which controled substance and lactose and caffeine which are uncontroled substance for Colombia. L9LV6L + + ANP Caffeine LC7LMZ + + + It has been detected the presence of Amfetamine in the sample. LLTO7L + + + This powder was found to contain amphetamine together with the adulterants caffeine and lactose LTTTTQ + + ANP Sample 2018/2/SM-4 was found to contain amfetamine and caffeine. MFE65O + + + The sample was analyze by GC-MS with differents solvents: Methanol, chloroform, ethanol and ethanol with internal standard. MJMMJM + - - The sample contains 7.4% amphetamine as a free base MR1LVU + + + Sample 2018/2/SM-4 contained Amphetamine, at a concentration of 7% (calculated as base), together with the adulterants Caffeine and Lactose. Amphetamine is a Class B controlled drug under the provision of the Misuse of Drugs Act 1971 (as amended). Caffeine and Lactose are not controlled under the provisions of the Misuse of Drugs Act 1971 (as amended). MSFAND + - - CAFEINE, LACTOSE MSHBVG + + + found Amfetamine with purity of 6.5%

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Code Amfetamine Caffeine Lactose N8BKMB + + ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 19. (1) Amphetamine (a-methylbenzeneethanamine) NAK5A7 + + ANP Sample 2018/2/SM-4 was found to contain amphetamine.The sample was also found to contain caffeine. NCCCCR + + + SM-4 was contained Amfetamine base.The test sample also contained caffeine, lactose NPEUNW + + + A composite was formed from 1 unit for testing of 1 unit received. Amphetamine (salt form and isomer not determined), caffeine, and lactose confirmed in the composite. NSALLN + + ANP TEST SAMPLE 2018/2/SM -4 CONTAIN AMFETAMINE AND CAFFEINE NVWID3 + + + After chemical analysis was performed the sample was contained AMFETAMINE, Lactose and Caffeine . OB929H + ANP ANP

OKBALQ + + ANP Caffeine OLWSRI + + ANP It include both amfetamine and Caffeine by adulterant ORPCAT + + + Table 2 Schedule 2, Psychotropic substances (used by medicine) PCYCJC + + ANP amphetamine is controlled by the Royal Decree of the 6th of september 2017 PM7GBZ + + ANP The sample contains Amphetamine sulphate. The purity of the sample is 6.52% as Amphetamine base. PMDM1U + + ANP White powder material that contains caffeine and drug under international controle - AMPHETAMINE. PMR0Q7 + + + positive for illicit substance PQIKKZ + + ANP with Caffeine PUTLIT + + ANP The sample contains amfetamine and caffeine. QBF6VQ + + ANP Caffeine and Lactose was found, but the Lactose was found and the Communiqué 2018-086-CAL- QUI Report of uncontrolled substances and traces in Competency Tests indicate that sharp suttances are not reported or outside the scope of the procedures. QJJYGQ - + + Cafeina y lactosa QJOV22 + + ANP It include both amfetamine and Caffeine by adulterant QMQ1QP + + - The sample contains amfetamine and caffeine as an adulterant.The substance is controlled in Poland. QORSXL + + + Amphetamine (6.2%), cafeine and lactose

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Code Amfetamine Caffeine Lactose QPXWKT + + + Presence of amphetamine sulphate, caffeine and lactose was detected in the sample. QRCK2V + + + lactose, caffeine QRDRJ1 + + + In the 2018/2/SM-4 was proved the presence of Amfetamine, Caffeine and Lactose. QTQQQ1 + + ANP amfetamine was detected by GC/MS and quantified by GC/FID R2YIAE + + + Examination and analyses performed on the solid in SM-4 showed it to contain amfetamine ( a central stimulant), caffeine (a xanthine stimulant) and lactose R7GREQ + + ANP Amphetamine and Caffeine confirmed in SM-4. RCBIBN + + + amphetamine, caffeine RDRW1X + + ANP It include both Metamfetamine by drug and Caffeine by adulterant. RPI8GV + + + Identified by GCMS & LCMSMS technique and quantified by GC-FID technique. RRFXUO + + + Sample contained Anfetamine as hydrochloride, Caffeine and Lactose. Identification of Anfetamine by GC/MS with Certified Reference Material of anfetamine, quantification by GC/FID. Identification of Caffeine by FTIR and GC/MS. Identification of LACTOSE by FTIR. S919AS + + - Sample turned white to orange colour with Marquis test and Amphetamine and Caffeine were found in GCMS analysis SBKWJS + + + ./. SHIGZS + + + The sample contains Amfetamine which is scheduled as illicit drug in France. The lactose and the caffeine are not scheduled as illicit drug in France. They are cutting agent. SRCKGX + + + The sample contains amphetamine. The content of amphetamine is determined to 9 % (as amphetaminesulphate). Amphetamine is a controlled substance in X. SUSSDP + + -

SV4SBQ + + ANP Powder contains Amphetamine (Amfetamine). Amphetamine is a controlled drug under the Misuse of Drugs Acts, 1977 to 2016. The amphetamine content of the powder was found to be 6.3 percent. SYLJNC + + ANP The sample contains Amfetamine (5.4%) SYYY0F + + + White powder containing amfetamine SZVWV9 + + +

T0PFVQ + + - We found both amphetamine and caffeine (non-controlled substance) in SM-4, but we are not able to give a quantitative result. TELOLF + + + In the sample SM-4 there is a amphetamine. Amphetamine is on the list of drugs.

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Code Amfetamine Caffeine Lactose U3WKHW + + - Very low concentration U479HU + + - Amphetamine UHJIRN + + - Also caffeine found UNNSU8 + ANP ANP Based on the above analysis, the sample was found to contain amfetamine USULOL + + ANP Satisfied with result obtained UTTTWF + + + Low amount of amfetamine V4HVM5 + - + The sample contained 6.7% amphetamine and also caffeine and lactose. VBO7OP + + - Addulterants: caffeine W7K0RA + ANP ANP we detected two spots in thin layer chromatography for SM-4. one spot was in amfetamine Rf and the other one was in ephedrine Rf. WEJJEJ + - + Base Amphetamine 6.43%, caffeine and lactose WMUWWC + + - cafeina anfetamina WPE9JA + + + amphetamine was detected by GC/MS but not quantified WV88U8 + + + LACTOSE WWWBLX + ANP ANP The sample was found to contain a controlled substance within the meaning of the Controlled Drug and Substances Act: Schedule I 19. (1) Amphetamine (alpha-methylbenzeneethanamine) XGLCLJ + + + we founded amphetamine in sm-4 after GC/MS injection XLNP6X - + + Caffeine and Lactose XUE0RE + + + The sample contains 6.79 % of Amphetamine and also contains Caffeine Y3XX1B + + + sample contains amfetamine, caffeine and lactose Y68SYY + + ANP On analysis of a representative sample of the powder Amphetamine was detected with a purity of approximately 7% (calculated as base). The presence of caffeine was also detected YMK92M + + ANP In the test simple 2018/2/SM-4 was detected amfetamine YQELRV + + + The sample contains amphetamine and caffeine. The concentration has not been determined. YQXDTM - + ANP White powder containing N-methyliminopropylbenzene (not quantified) and caffeine (not quantified) YS66H6 - + ANP

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code Amfetamine Caffeine Lactose YSSSDR + - +

YYONQA - + ANP White powder containing caffeine Z00LTY + + ANP 2018/2/SM-4 has been detected containing Amphetamine. Z7F75I - + ANP CAFEINE Z7JWAE + + + The white powder was analysed and found to contain Amphetamine. ZJZZZ3 + - - In the identification part Amphetamine, sugar and cafeine are found. In the quantification part the ratio of amphetamine is calculated as 7%.

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Identification methods for Test Sample 4

Legend : S ... used for Screening I ... used for Identification SI ... used for both

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Code 140 141 142 150 160 161 171 180 190 200 211 230 231 250 210 YYONQA I SI Z00LTY SI I Z7F75I S S S I I Z7JWAE S I I ZJZZZ3 SI I

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

RESPONSE SUMMARY FOR TEST SAMPLE 4

Participants: 194

The response summary of all 194 participating laboratories for the identification of SM-4, frequency of use of screening and identification techniques and false positives and negatives:

Correct identification of Test Sample-4:

Substance Name Number of laboratories Amfetamine 180 Caffeine 166 Lactose 102 False positives for Test Sample-4:

Round Code Substance Reported Tech Code FPTIMV Metamfetamine (minor) 150, 180 H6MPDC Cocaine 150, 190 ORPCAT Metamfetamine 150, 180 W7K0RA Ephedrine 150 XGLCLJ Formetamide 180 YQXDTM N-methyliminopropylbenzene 180 Z7F75I Metamfetamine 180, 231

False negatives for Test Sample-4 with respect to Amfetamine (techniques(s) used):

Round Code Tech Code Round Code Tech Code 02OWVV 180 QJJYGQ 180 , 190 2BSDEQ 171 , 180 XLNP6X 180 , 190 2P2PU2 150 , 180 YQXDTM 180 , 171 7JGGMW 180 YS66H6 180 BUHHL2 180 YYONQA 180 , 171 F9BYIQ 171 , 180 Z7F75I 180 , 231 JDZDJJ 150

Analysis not performed for Test Sample-4 with respect to Amfetamine:

Round Code BSWNB0 ANP

Frequency of use of screening, identification and quantification techniques:

Response Summary Participants 194

Technique 140 141 142 150 160 161 171 180 190 200 210 211 230 231 250 Screening (No.) 66 74 65 20 2 4 8 70 17 1 2 0 1 0 4 (%) 34.0 38.1 33.5 10.3 1.0 2.1 4.1 36.1 8.8 0.5 1.0 0.0 0.5 0.0 2.1 Identification (No.) 21 11 10 39 6 16 27 178 85 3 10 2 3 5 4 (%) 10.8 5.7 5.2 20.1 3.1 8.2 13.9 91.8 43.8 1.5 5.2 1.0 1.5 2.6 2.1 Quantification (No.) 0 0 0 0 8 25 46 10 0 0 1 1 1 2 0 (%) 0.0 0.0 0.0 0.0 8.4 26.3 48.4 10.5 0.0 0.0 1.1 1.1 1.1 2.1 0.0

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Score Report per Sample per Substance:

Round: 2018/2 Robust average: 6.6% Substance: SM-4; Amfetamine UNODC value: 7.1 %

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Score Report per Sample per Substance:

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Z-Scores for Test Sample 4

Amfetamine Amfetamine Deviation Deviation Code Concentration from Code Concentration from z-score z-score (mass%) robust (mass%) robust average average NVWID3 2.1 -4.5 -5.7 4FMLRF 6.7 0.1 0.1 ECOCCC 3.0 -3.6 -4.6 V4HVM5 6.7 0.1 0.1 7P5A33 3.0 -3.6 -4.6 EDHZTN 6.7 0.1 0.1 LC7LMZ 3.2 -3.4 -4.3 HPIHHH 6.7 0.1 0.1 U3WKHW 3.4 -3.2 -4.1 KOQ1NC 6.8 0.2 0.1 8XQEGQ 4.6 -2.0 -2.5 XUE0RE 6.8 0.2 0.2 4STTTT 5.0 -1.6 -2.1 KHGLHU 6.8 0.2 0.2 RDRW1X 5.0 -1.6 -2.0 RPI8GV 6.8 0.2 0.2 AAPSTZ 5.2 -1.4 -1.9 006FMT 6.8 0.2 0.2 QPXWKT 5.2 -1.4 -1.8 DIIBXI 6.9 0.3 0.3 YMK92M 5.3 -1.3 -1.7 CTRBHS 6.9 0.3 0.3 HATVYH 5.3 -1.3 -1.7 7UN77R 7.0 0.4 0.4 SYLJNC 5.4 -1.2 -1.6 TELOLF 7.0 0.4 0.4 3JJ2TA 5.5 -1.1 -1.4 NPEUNW 7.0 0.4 0.5 HI4WNN 5.5 -1.1 -1.4 AIW1Z2 7.0 0.4 0.5 QMQ1QP 5.6 -1.0 -1.3 Y68SYY 7.0 0.4 0.5 BAYSRL 5.8 -0.8 -1.1 ZJZZZ3 7.0 0.4 0.5 49LF34 5.9 -0.7 -1.0 SHIGZS 7.0 0.4 0.5 OLWSRI 5.9 -0.7 -0.9 MR1LVU 7.0 0.4 0.5 QJOV22 5.9 -0.7 -0.9 9DKDUD 7.0 0.4 0.5 9N8FTT 6.0 -0.6 -0.8 RRFXUO 7.1 0.5 0.5 VBO7OP 6.0 -0.6 -0.8 BLBOCB 7.1 0.5 0.6 LLTO7L 6.0 -0.6 -0.8 K9O99N 7.1 0.5 0.6 9WFUHI 6.0 -0.6 -0.8 SZVWV9 7.1 0.5 0.6 8828D8 6.0 -0.6 -0.8 AEFKAT 7.2 0.6 0.7 4EF44P 6.0 -0.6 -0.8 WV88U8 7.2 0.6 0.7 07RNYQ 6.1 -0.5 -0.6 HGGHOG 7.2 0.6 0.7 QORSXL 6.2 -0.4 -0.6 5W5519 7.2 0.6 0.7 1PSOP9 6.3 -0.3 -0.5 UTTTWF 7.3 0.7 0.8 SV4SBQ 6.3 -0.3 -0.4 9QNQPB 7.3 0.7 0.8 FPTIMV 6.4 -0.2 -0.3 DPAIVA 7.3 0.7 0.8 PUTLIT 6.4 -0.2 -0.3 1IIEIC 7.4 0.8 1.0 WEJJEJ 6.4 -0.2 -0.3 MJMMJM 7.4 0.8 1.0 IL7F1S 6.4 -0.2 -0.3 PCYCJC 7.4 0.8 1.0 CMZFLS 6.5 -0.1 -0.2 A8R888 7.4 0.8 1.0 SRCKGX 6.5 -0.1 -0.2 3CUTP4 7.5 0.9 1.1 CLRNDG 6.5 -0.1 -0.2 7Z33IM 7.6 1.0 1.2 MSHBVG 6.5 -0.1 -0.2 HRZZZ0 7.6 1.0 1.3 RCBIBN 6.5 -0.1 -0.2 HDYYZY 8.0 1.4 1.7 PM7GBZ 6.5 -0.1 -0.1 OB929H 8.3 1.7 2.1 60XF00 6.6 0.0 -0.1 UHJIRN 8.5 1.9 2.4 31933H 6.6 0.0 -0.1 555HC5 8.8 2.2 2.8 AOZMSG 6.6 0.0 0.0 IXI4IQ 8.9 2.3 2.9 AIQBL5 6.6 0.0 0.0 4QMQQQ 11.0 4.4 5.5 55IZ55 6.6 0.0 0.0 YSSSDR 11.7 5.1 6.4 QTQQQ1 6.6 0.0 0.0 14YQYB 26.2 19.6 24.8 DYZ53I 6.6 0.0 0.0 Y3XX1B 87.7 81.1 102.6 QRCK2V 6.7 0.1 0.1

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Laboratory and Scientific Section UNODC, Vienna International Centre Wagramer Strasse 5, P.O. Box 500 A-1400, Vienna, AUSTRIA Email: [email protected]