Assessment of Eating Behavior Disturbance and Associated Neural Networks in Frtontotemporal Dementia

Supplementary Online Content

Ahmed RM, Irish M, Henning E, et al. Assessment of eating behavior disturbance and associated neural networks in frtontotemporal dementia. JAMA Neurol. Published online January 25, 2016. doi:10.1001/jamaneurol.2015.4478.

eTable. Voxel-Based Morphometry Results Showing Regions of Significant Grey Matter Intensity Decrease for the Contrasts of Alzheimer Disease, Behavioral Variant FTD, and Semantic Dementia Groups With Controls

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Downloaded From: https://jamanetwork.com/ on 09/27/2021 eTable. Voxel-Based Morphometry Results Showing Regions of Significant Grey Matter Intensity Decrease for the Contrasts of Alzheimer Disease, Behavioral Variant FTD, and Semantic Dementia Groups With Controls Regions Side No. of Voxels MNI Coordinates x y z AD versus Insular cortex, Heschl's gyrus extending into superior L 5290 -40 -18 2 controls temporal gyrus, middle temporal gyrus, inferior temporal gyrus, planum temporale, planum polare, central opercular cortex, precentral gyrus, parietal operculum cortex, supramarginal gyrus, angular gyrus, and lateral occipital cortex Supramarginal gyrus extending into angular gyrus, R 4395 42 -46 14 parietal operculum cortex, planum temporal, superior temporal gyrus, middle temporal gyrus lateral occipital cortex, and occipital pole Superior frontal gyrus extending into middle frontal L 2262 -20 4 48 gyrus, inferior frontal gyrus, precentral gyrus, and frontal pole Amygdala, parahippocampal gyrus extending into L 1843 -16 0 -20 hippocampus, thalamus, putamen, temporal pole, precuneous cortex, lingual gyrus, posterior cingulate gyrus, insular cortex, and orbital frontal cortex Occipital pole, occipital fusiform gyrus extending L 1022 -20 -92 -10 into lingual gyrus, and lateral occipital cortex

Occipital fusiform gyrus extending into lateral R 455 22 -86 -8 occipital cortex, and occipital pole

Superior frontal gyrus extending into middle frontal R 330 20 22 40 gyrus, and frontal pole

bvFTD vs Bilateral paracingulate gyrus extending into bilateral B 14917 0 48 20 controls anterior cingulate gyrus, bilateral superior frontal gyrus, bilateral middle frontal gyrus, bilateral inferior frontal gyrus, bilateral precentral gyrus, bilateral supplemental motor cortex, bilateral frontal pole, right orbital frontal cortex, right frontal operculum cortex, right postcentral gyrus, right insular cortex, right caudate, right accumbens, right putamen, right amygdala, right parahippocampal gyrus, right hippocampus, right superior temporal gyrus, right middle temporal gyrus, right inferior temporal gyrus, right temporal pole Left temporal pole extending into left temporal B 13578 -32 6 -32 fusiform cortex, left superior temporal gyrus, left middle temporal gyrus, left parahippocampal gyrus, left hippocampus, left amygdala, left caudate, left accumbens, left putamen, left insular cortex, left frontal operculum cortex, left inferior frontal gyrus, left frontal medial cortex, bilateral orbital frontal cortex, bilateral subcallosal cortex, bilateral frontal pole Cerebellum extending into occipital fusiform gyrus R 1426 40 -58 -42

Occipital fusiform cortex, occipital pole extending R 441 22 -86 -8 into intracalcarine cortex

Right precuneous cortex, right posterior cingulate B 159 4 -48 38 cortex extending into right precentral gyrus, right postcentral gyrus, left precuneous cortex, and left posterior cingulate cortex Semantic Temporal fusiform cortex extending into temporal L 14427 -30 -8 -50 dementia vs occipital fusiform gyrus, inferior temporal gyrus, controls middle temporal gyrus, superior temporal gyrus, temporal pole, parahippocampal gyrus, hippocampus, amygdala, putamen, planum

Downloaded From: https://jamanetwork.com/ on 09/27/2021 temporale, Heschl's gyrus, parietal operculum cortex, supramarginal gyrus, angular gyrus, lingual gyrus, lateral occipital cortex, insular cortex, frontal operculum cortex, and orbital frontal cortex Inferior temporal gyrus extending into temporal R 4501 40 0 -48 fusiform cortex, temporal pole, insular cortex, amygdala, hippocampus, parahippocampal gyrus, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, and orbital frontal cortex All clusters reported using threshold free cluster enhancement technique (tfce) and corrected for Family-Wise Error (FWE) at p < .05. All clusters reported at t > 1.73 with a cluster threshold of 100 contiguous voxels. AD = Alzheimer’s disease; bvFTD = behavioral variant frontotemporal dementia; SD = Semantic dementia; L = Left; R = Right; B=Bilateral; MNI = Montreal Neurological Institute. Age is included as a nuisance variable in the analyses.

Downloaded From: https://jamanetwork.com/ on 09/27/2021