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Molecular Diagnostics in Personalized Medicine|Personalized in Health Care|Personalized Medicine in Psychiatric Disorders|Economics of Personalized Medicine

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Molecular Diagnostics in Personalized Medicine|Personalized in Health Care|Personalized Medicine in Psychiatric Disorders|Economics of Personalized Medicine conferenceseries.com 845th Conference 5th International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics December 01-02, 2016 Valencia, Spain Work Shop (Day 1) Page 21 Raghda Abd El Lateif Hafez, J Pharmacogenomics Pharmacoproteomics 2016, 7:4(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2153-0645.C1.012 5th International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics December 01-02, 2016 Valencia, Spain Raghda Abd El Lateif Hafez Zagazig University, Egypt Assessment of the role of interleukin 17A and interleukin 17F in chronic hepatitis C virus infection in Egyptian patients hronic HCV infection is a major clinical and public health problem. The estimated number of infected exceeding 170 million Cworldwide with Egypt has the highest prevalence 14-20% with per dominate genotype 4. The host immune response plays a unique role in HCV infection. Emerging data implicate T-helper 17 cells may play a role in the pathogenesis of chronic hepatitis C infection. This study was conducted to elucidate the role of T-helper 17 cytokines, interleukin 17A and interleukin 17F in the pathogenesis of chronic HCV infection and included two groups, the first group 51 non-treated chronic HCV patients and the second group included 51 healthy blood donors as a control group. The serum levels of interleukin 17A (IL17A) and interleukin 17F (IL17F) were quantified using sandwich ELISA. The serum levels of interleukin 17A was significantly higher in chronic HCV patients group Mean (52.9±32.6 pg/ml) than in the control group (17.1±10.4 pg/ml). There was no significant difference regarding interleukin 17F between the two groups, although slightly higher in chronic HCV group (18.9±26.3 pg/ml) than the control group (14.6±6.1 pg/ml). Among the cases there was a highly significant correlation between IL 17A and viral load, duration of illness, sonography, liver enzymes and biopsy. There was weak negative correlation between IL17F and viral load, liver enzymes and liver biopsy. The higher serum level of interleukin 17A in chronic HCV group suggest its implication in the pathogenesis of chronic HCV infection and its positive correlation to the severity of liver injury can use it as a new marker for disease prognosis. On the other side Interleukin 17F may have a protective role. Biography Raghda Abd El Latief Hafez is presently working as a Professor of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Egypt. She was the Director of Infection Control Unit, Zagazig University Hospitals in 2015. She has obtained her Master’s degree in Medicine & Surgery (MBCHB) in 1994 and PhD in Bacteriology and Immunology in 2004 from Zagazig University, Egypt. She is a Member of Egyptian Society for Medical Microbiology, Member in Egyptian Association Immunology and Member in Egyptian Society of Infection Control. [email protected] Notes: J Pharmacogenomics Pharmacoproteomics Euro Personalized Medicine 2016 Volume 7, Issue 4(Suppl) ISSN:2153-0645 JPP, an open access journal December 01-02, 2016 Page 22 conferenceseries.com 845th Conference 5th International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics December 01-02, 2016 Valencia, Spain Scientific Tracks & Abstracts (Day 1) Page 23 Sessions: Day 1 December 01, 2016 Pharmacogenomics in Personalized Medicine|Molecular Diagnostics in Personalized Medicine|Personalized in Health care|Personalized Medicine in Psychiatric Disorders|Economics of Personalized Medicine Session Chair Session Co-Chair Ramon Cacabelos Jack Kushner EuroEspes Biomedical Research Center, UK George Washington University, USA Session Introduction Title: The neuronal connectivity of our thoughts into actions Jack Kushner, George Washington University, USA Title: An ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatment Julián Gorrochategui Guillén, Vivia Biotech, Spain Title: Predictive, preventive and personalized medicine (PPPM) as an upgraded model of national and international healthcare services to secure a future of clinical research and practice: How to promote the higher medical education Irina Zhegalova, First Moscow State Medical University, Russia Title: Impact of research methodology workshop on ability to solve research issues Muhammed Irfanullah Siddiqui, Umm Al-Qura University, KSA Title: Acupuncture treatment for 18 cases of facial paralysis. (bells palsy) Sukhwinder Singh, Guru Kirpa Acupuncture Health Centre, India Title: Genetic regulation of lymphocyte specific proto-oncogene (LCK), differentially selects the right MHC class I variants against a disease Daniel A Achinko, Howard University, USA Title: Economics of personalized medicine Kamal Kumar Chaudhry, Princess Pharma Pvt. Ltd, Nepal Page 24 Jack Kushner, J Pharmacogenomics Pharmacoproteomics 2016, 7:4(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2153-0645.C1.012 5th International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics December 01-02, 2016 Valencia, Spain The neuronal connectivity of our thoughts into actions Jack Kushner George Washington University, USA hile most of us use and enjoy the Internet every day, we do not imagine that our brain has more interactivity and connections Wthan the entire worldwide web. In fact, 20 years from now, there will still be more connections and interconnections in one human brain than in all the servers and networks used by the Internet. It is the brain that separates humans from all others in the huge animal kingdom. Our brain can receive information via our olfactory, visual, tactile and auditory senses simultaneously. It can compute information stored in its recesses, have decision making capabilities based on incoming information and can immediately take action by controlling other parts of the bodies. In February, 1943, Erwin Schrodinger (1887-1961) a Nobel Prize physicist from Austria, gave a lecture at Trinity College, Dublin, Ireland entitled “What is Life?” He identified the problem as follows: Incredibly small groups of atoms much too small to display exact statistical laws play a dominating role in the very orderly and lawful events with a living organism. This presentation explains how we concentrate and focus and cause these particles to go into an organized formation and initiate enzymatic activity. In addition, we shall discuss how mutations occur in somatic cells including those neurons in the brain. These mutations occur more often in the genes a neuron most often uses. By sequencing individual cells rare mutations are illuminated. Biography Jack Kushner was graduated from Tulane University and University of Alabama Medical Center, USA. He did a Surgical Internship at George Washington University and a General Surgical Residency at the University of Michigan. He has served as a combat Surgeon at the 91st Evacuation Hospital in Vietnam and completed his Neurosurgical Residency at Wake Forest University. He is a board certified Neurosurgeon and practiced Neurosurgery in Annapolis, Maryland. He has obtained his Master’s degree in Finance from the University of Maryland while practicing neurosurgery. Later he founded a medical transcription company in Bangalore, India and worked on a medical telemedicine and surgical simulation project in Israel. He has received an Honorary Professor of Medicine and Healthcare Award in Cambridge, England and he was made an Honorary Director General of the World Forum in Oxford, England. Presently he is working with George Washington University to create a Genomic Medical Center in Viet Nam. He has lectured at many universities in the USA and around the world. [email protected] Notes: J Pharmacogenomics Pharmacoproteomics Euro Personalized Medicine 2016 Volume 7, Issue 4(Suppl) ISSN:2153-0645 JPP, an open access journal December 01-02, 2016 Page 25 Julián Gorrochategui et al., J Pharmacogenomics Pharmacoproteomics 2016, 7:4(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2153-0645.C1.012 5th International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics December 01-02, 2016 Valencia, Spain An ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatment Julián Gorrochategui Guillén and Juan Ballesteros Vivia Biotech, Spain e have overcome the limitations of 40 years of ex vivo testing by developing a novel test (based on studying the ex vivo sensitivity Wto drugs) to predict the complete remission (CR) rates after induction chemotherapy with cytarabine (Ara-C) and idarubicin (Ida) in 1st line AML. This has been an observational clinical trial where bone marrow samples from de novo AML adult patients in Spanish PETHEMA centers were included. Whole marrow samples maintaining their native environment were incubated for 48 hours in well plates containing Ara-C, Ida or their combination. Pharmacological responses are calculated using population models. Induction response was assessed according to the Cheson criteria (2003). Patients attaining a CR/CRi were classified as responders and the remaining as resistant. 390 patient samples were used to calculate the dose response curves synergism and 155 patients were used for clinical correlation. The strongest clinical predictors were the Area Under the Curve (AUC) of Ara-C (P=1.34E-05) and IDA (P=3.9E-05). The GAM models revealed
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