Down- regulated genes

Normal to Latent Infection Normal to Active TB Latent Infection to Active TB Level 0 Level 0

B3GALT2 Level 0 B4GALT1 LACC1 MAPK8IP2 BACE1 BANP PPP1R10 FBLIM1 RGS13 LALBA RBBP7 PMEPA1 FERMT2 TP53BP2 SEC23A PARD6B HIST1H2BNMDC1 GGA2 CCBL1 DPYSL4 SLC7A1 NMNAT1 HYAL2 KCNJ2SEC24B AXIN2RBBP4 HIST1H2BM BCAT1 CASP7RPA1 CDCA8HIST1H2BJ DCC ASS1 ROR2 COMT CYP1B1 SLC7A11 FZD9 NMNAT2 FOXH1 HIST1H2BHLMNA DENND4A DPYSL2 OTC SEC31A EPHX1 PKNHIST3H2BBHIST1H2BA2 BCL10 APAF1 APBB1 KMO FNDC3B DPYSL5 DPYS INCENP RARA UBA1 RPS15 TTC12 AHSA2 NMNAT3 ANAPC11 CD109 IL18BP IL1R2 KYNU CRMP1 SCAP TTC31 NUMB NET1CASP2 RPL36RPL37 DPYSL3 ARL5BMYO1RPS150 RPL26 HIST1H2BBHIST1H2BLHIST2H2BEGADD45ASIRPA TP53BP1 CXCR7 RPS5 KANK1 FZD6 PFKFB3 SUGT1P3 SLC7A5 MAPT H2AFX MAPKAPK2 RPS11 RPL35 RPL4 APBB1 RPS25 ADK FZD5 RNF111 NFKBIBHIST1H2BKPKN1 MAP3K8 RPS3A RPL13A IL18BP SLC2A3 RPL30 RPL14RPL9DHODH GSTM1 ACVR1B PAX3NFKB2KLK3RIPK2NR3C1 UBE2V1 RPS4X HAAO FZD1 CPS1 RPS24 RPS7 PARD6G RICTOR PEA15 HDAC2 BCL2L11HIST1H2BO ITGALIL23R IRG1 TFPI RPS4X UPB1 CEBPB TRADD CCBP2 CCL19TOLLIP RPS15A RPL18 INSIG1 F10 IL36G F9VEGFB RPSARPL17 AR CCL25 CXCL6 RPL37A RPS9 NAMPT UMPS RPS21 RPS28 RPS23 APC CDK6NOTCH3 CDK1RB1TCF7MDM2 SIN3A MET CXCR6 CXCR1 RPS29IL1RARPL7AP RPL10L TDO2 DPYD RPL4 GFPT2MAPK8IP3GSTP1 F9 PPBP RPS4Y2 JUNB LRP5FZD2 DVL3 FZD10 RPS20 RPL18A RPS26RPL31RPS10 ARHGDIAPRKCZPCNA CDKN2ALEF1 BIRC3 CXCR2 CXCLIFNAR3 1 RPL34 TFPI2 NRP1 NCSTN SPAG9AXIN2 AK4RPL10A RPS13 PARD3 DUSP1IRAK1HPGDSPARP1TLRTNFRSF12MAPK10BADCDK2A NFATC2 NCOA2 CCR1 RPS18 IFITM3 CAD RPS11RPS9 RPL13 EIF4G3 PRKCINTRK1MAPK7MCL1 CASP8 CASP9 SELETLR6 LTA F5CXCL5 IL1RN CCRIL17R8 A IFITM1 LRP6 FOSBATXN1 PDCD4 TAB1 SIRT1ATF2 FOSL2 FADD ALOX15 IL4R STAT2 NRP2 ITGB8 FZD7RYK FZD5 NUP37SEC31BRPS3A RPL18 RPL35A MYO5C NOTCH2 NOTCHBDNFCTNNB1FOXO31 NCOA1 HIST1H2BDTRAF2NCOR1 FOSB ALOX12 IL6STCCR3 IFNGR1 CXCL9 IL1R2 RPL35 RPS27RPL23A RPS8 FOXO1CASP1 TCF7L2 F2FOXO1R IL1A IRAK2 SUGT1IL1RAP DVL2 RPL32 RPS14RPL3 RPL36 RPS12RPL11 SPECC1L NOTCH4 RPTOADRA CDK4 BIRC2SERPINEMAP2K7BIRC51 TICAM1 UBE2N IL18BP CCL21NLRP3 BST2 IFI6 CDC37RPS3 RPL37 RPLP2 EIF4GMTO1 SMURF2R NGFMAPK14 EP300 CFLAR CXCL10 JAK3 IL6TLRR7 PLAT WNT5A RPL27A MDM4 CREBBPAKT2IRS1BCL2 UBA52CD40MAPK8CCND1ATM IL18RAP SLC39A8 PFCXCL134 IL23A CCL4 PGF TIMP1IRAK4 FZD8 APCKIAA1199ARF6 RPL10LRPS17 RPL7A MAP3K7 BCL2L1INS MAPK9 IL1R1 PYCARDSTAT6CCL4LIL10RA1 CASP1 LY96 SERPINB9 CXCR2 EMP2SELEFLNA JUND FOSL1SLC3A2DVL1 PFKM FAU PARD6AUGT1A1UGT1A6 RPS6KB1 TP53PIK3CD JURELN RELA PLA2G2C STAT5BCSF2 MAVSCXCL11 SPP1 BIRC2 DDIT4 RPLP1 AURKA PIK3CGCASP3 FOIL1BS CD289CXCLRELB5 TNFRSF1B PLA2G4A PTPN11CCR5 CCL20LEP IFIT2 F3 OLR1 MAP3K7 FZD3 RPS15A RPS29RPL15 CYP1A1UMPSPAK3 PSEN1 CDKN1A CXCR4 IL2RG CCL5 RNF31 IFI44 PTGES3 RPL34RPL5RPS5RPS2RPL37ARPL24 RPL19 APRT MAPK11FLTCYCS1 PPARG TRAF6 CXCR3 TICAM1 DDX58 CXCL3 FZD4 GEM CD289 KIT AHSA1 RPS19 WNT5A IRAK4 IL6TNF CXCL1 TNFAIP3 CXCR5 CSF2RAIL12B STAT3 IRF9 MMP7PSEN1CD44 STIP1 KLC1 NUP133RPL21 TAB2 AHRR AXIN1IL2RG HSP90AA1KDR PIK3CANRASMAPK3MAPK1AKT1SMAD4 ILCD40LGTAB28 IL5 CXCL9 CCRIL2RACCL112 CCL2 CXCL12 STAT5A IRF1IRAK3 MX2 PLAURTNFSF9 CASP1 RIPK1 HSPA8 CYB5R4 BMF EIF4EBP1 RAF1SMAD3CD36MYCPTEN CSF2TLR4 IL18 NFATC2ALOX5 CXCR3 GBP2EIF2AK2 CCRL2 KDRMAPKMMP99 RPS6RPS16RPLP0 SEC13RPL22 PAK7 SLC3A2 CTNND1 ERBB2JUNDMAP2K4XIAP ICAMBAX1 IL17ALY96 CYP2EPLA2G1 5 MITF TLR4 IL18 MXIFIH11 IL24 IL18 PLGIL1B SERPINE1 HSPA4 KMO EFNA4SNAIIL6ST1 PIK3CB CREB1PTPN11 IKBKG CCL21 NCR3LG1 PLA2G10 HBEGFATF3PTENIL2 FOS HERC5 SERPINB8 TICAM1 FLT1 NOTCH1 CUL4A UBA52 RPL23 NXF2B GART CDC42 IKBKB FOXP3 THBD F7 IL1R1 IRS1TLR2 IRAK1 IFI35 IL1R1 CTNNB1IKBKBEGF GSK3BSUMO2HSP90AA1 NEDD8NUP107 GSTTGFPT11 TGFB1 IL3 CXCL2 CXCLCCR7CD4IRAK1 IL40IL174 IFNAMAPKG 9 IFIT1 THBS1 MYD88SLC39A8 CAT NR3C1 RPS27ATTC28 ACACB PAK2EPHAEIF4E3 GSK3BRHOA CHUKPLK1 NFKBIAHAR IL1ACXCL2 SERPINB2 AREG IL1JAK20 STAT1TLR3 USP1ISG208 CCL4 CCL5 IRAK1 CASP8 TRIM36 NXF1 RHEB SRCSP1 IFNG FASLG BCL3CCL5 LEPR TYK2 JAK1 IRF3TIRAP IFIT3 SERPINC1CD47 PLAUVTNF7 NCR3 MAPKJUN1 CHUKRPA1 AMPD3 DPYD CAD MYODCDH11 EGFRPLAU RIPK1 IL2 APP IL1RN NCR3 TFPI HRASCASP8MAPKCXCL103SOCS3CBL PIK3RRNASEIRAK1 2L CXCL1CD40LGOSMF2 CXCL12 MAPK8 AXIN1 RANBP2SUMO3 NME4 EPHA1 HEY1SHC1 STAT3VEGFAHIF1A CD2 IL5 IFI44L PSENENTNFAIP6 SERPINB2CXCR1 PTGESCRP CD40 MAPK3 CEBPB PLK1 NUP85 NUP98 CTNNA1 IGF1REGF NGFINSRR FAS MAPK8IP1 VEGFRPS6KB1A NRAS PIK3CACD289 XIAP IL1B JAK2 VEGFAPPA STAT3 SOD2 SEH1L IL2RB HRAS TIMPNFATC11 PLA2G1SERPINCBKSR2 1 NRG2IL6 IL12RB1IL8IKBKG MYD88 DARCTNIP1 TRAFTNF6 FOS VHL NUP50 NGEFOXO4SMADF PIK3R12 CXCR4 IL2RA CCL19 ERBB3 FASLPTGSG 2 CASP3 IRF7 CD80 IL2 EGFRAKT1 CCND1 POLA1RBX1FLNB CDC23NUP43 AFMID CPS1 DOCK1EPHASKI2 L COL5A2RRAS PAK1TLR3MMPMYD8UBE2D9 8 3 EPOR TRAF3 CXCL13 EGFR APH1B TRAF1 TLR4 CXCL10 CUL1 HIST1H2AD CDH2 EPO PLIN2 CD82 SERPIND1 HPGDSFOSL1 EGERBB2F TLRIKBK8B UBE2L6 IFI27 STAT5BIL6 MAP3K8 RB1 HMMR RANRANGAP1 EFNB1 EPHB2 CXCR2 CCRL2 CRP SOS1MAPK1 TNFRSF1ATCEB1 TNFSF13BCXCL2IL2RA CSF3EPOTNFRSF1A ESR1RELANFKB1NFKBIA MYC BIRC3PCNAAR BUB1 BUB1B PFAS EIF4A1RPS6GRB2 TSC2 DIABLO CCL11 NFATC3 AKT1 XAF1 LIFR IL10 IKBKG EIF2C2 H2AFZPTTG1 EPHB4 PXNRASA1 HGF PLAUR CCR3 ABCG1 PLA2G2A F2 RIPKIL2R1TLR6B HSP90AB1 CXCR4 UBE2CCDK4 DICER1 KPNB1 EPHB6 TRAF1 PLGEPHB3 DUSP8 F3FOSL2 ICAM1 MAPK14MAPK8 TRADD PTGES3 RSAD2 PTGS2 IL4 ANAPC10 CCNA2 CCNB2 DPYSL2 COL6A3PAK6 CRTAJUNBP DUSP16 CXCR1 PTGES CEBPB MAP3K7NFKBIA NCR3LG1 IL8 BTRC CKS1B AURKB UBE2M RAE1 CCBL1 DPYSKYNU BCAR1CBLTGFBR1 FLT4 FOSLCXCL121 TRAF6 JUN H2AFCD40LHIST1H2AY GHIST2H2ABIRCA 2B UBA7 FADD TNFRSF9 IL17RATRADD NCOA3CDC20CCNB1 CRK RBPJ CXCL11 F10 GRB2CASP9 CHUK HGS CCR6CD28 SIRPAIL12B IL17ASTAT1 HIF1AKRAS SKP2NUP153EIF2C3 NUP160 DUSP4EPHA6 CSF2RA NOS3 HEY2CSF2RB IL6R FGG EREG MAP2K1 TNF HSP90AA1FADD BIRC3GABRPS22ISG1RPL15PSMD145 RPL30UBE2A RPS10 CCR5 FOXO3KITLGCDKN1A PYCARD ANAPC2 MAD2L1 EFNA1ACACA VWF NFATC3 IL1R2 P2RY10 KRASFLT1 NFKBTLRPSMC61 1RPS3RPL14 TAB2 ADAM1OAS72 RPS8 CD86CARD8 NLRP3 CDK2 RPA2 UBE2I EPHA4 UBE2D2SOS1 ATF3 PF4CCL20 CYP2B6 RELA PSMC1 RPL10TAB1 RPS7 IL4R CTNNA1 TNFRSF1BIL1A TCEB1 CCNA1 CDC6MCM8ORC1 TPR DHODH EFNB2GAB1ASS1 FAPSMD6S TRAF2 RPL32RPS23 APH1A CCR1 CSF3RIL23A TRAF2 H2AFX CDC27 HIST2H2AA3FBXL19 DPYSL4 EPHA5 EFNB3 NTRK2 THBS1 POFUT2 RBCK1TNFRSF1BSHC1UBE2B TRAF3RPS19 OAS3OAS1 IL10RA SOCS3CDKN1BFBXWEPOR7 OTC EPHB1 AURKB PTGES2 CFLAR KDRRPL35AH2AFRPS1X 4 RPL26 TNFAIP3 SKP1 CDK1CCNFMCM4 CRMP1 LEPRE1 ITGAL STK38L CCR7CCR5F8 GAB1 HIST1H2ABHIST2H2ACTRAF1PSMD1RPS28SIRT1PSMCUB2RPS20C OASRPLP2L RPS2RPS256 TNFRSF13C FAS RBPJ TNRC6C BUB3ORC2 BAG4DIABLO TNFAIPTNFSF13BRAF3 B ERBB4 RPL6 RPL24UBB CCL20CTLA4STAT5A SOD1 HIST2H2BEHIST2H2ACMCM7 XPO5 CCBL2 UCHLPSMD115 RPL7 GNB2LHIST1H2AEUBA51PSMB2RPL288 RPL27RPL9 RPL5 IRG1 CDC25A MCM6CCNE1 ORC4 MCM10 EPHA7 ENSG00000251246 CD58 CD47 PTX3 HIST2H2BLTAERPS13 RPL13 IL6RCCL23 NCOA2 DHRS9 ANAPC1 PRIM1 CCNE2 SUN1 ARHGAP1VEGFC HRG LTBR HACE1 RPS27RPS27L RPS24 RPL11 PTX3 THPO FOSL2 CENPAckshs1 EFNA2 COL1A2 JUND NFKBCENPA2 RPL19PSMB4 RPL18ARPS16 NFE2NCOA1 ATF3 CDC16 CCDC14 SLC7A11 EFNA5 TFPI2 CYLDPSMD13H2AFZ PSMA6RPL21 RPS6 RPL31 PLA2G4ACCND2 CDC45 EIF2C1GINS2ANAPC4 DBF4 DPYSL5 DPYSL3 KSR1 NRG1PSMA4PSMBHCK 3 PSMB11RPL26L1PSMBPSMA7 7PSMB9 RPL8 HEY1 CCND3 CUL2 CDC7 OXNAD1 SPARC CASP7 TNFRSF12A RPS4Y1RPL36RPL36ALA FARPL23RPS27AURPL3 OSMR HIST1H4CMCM5GINS1 TARBP2 ABCB4 SMPD2 UBE2PSMBN 1RPS21 RPL27A EREG RBL1 CDT1SYNE2 MCM3 EFNA3 SH3KBP1ITGB8 COL1A1 FOSB RPL38 GPX5 TNFRSF13CH2AFTNFSF12J PSMD4PSMD8 IL6ST PPAP2B MCM9 NFKB1 PSMB6PSMA3PSMBPSMC52 HIST1H2BB GATA3 GINS3 JUNB MAPKAPK2 PSMA8 MAFF SOD3 GINS4 MMP19 ZHX2 PSMBPSMC45 HIST2H2AA3PSMD2 HIST1H2AD RPL12 ORC5 WDHD1 PTGIS ALOX5 ID3 TNRC6AGPX1 MCM2EIF2C4SYNE1 DOCK4 H2AFV PSMD7 GPX3 HIST1H2AB COL5A1 TNFRSF17 PSMD3 HIST3H2A ADORA2A PSMD12PSMA5 IQGAP3 TNRC6B HIST1H2AE ARHGEF15 GPRC5A COL3A1 H2AFB1 PSMD10 PSMB10 SGPP2 G0S2 MSC ETV6 PSMD9 PSMAPSMC31 GPX2 MCMBP PPIB GPX7 GPX6 MAMLD1 PSMA2SHFM1HIST1H2AC USP14 TNIP3 ADRM1 AREG TNF CSF3, MAP3K8, IRAK2, TNFIP3, TRAF1, PLAUR, CD44 ET CL4, IL1A, IL1B V6, ME C FNDC3B GEM ATXN1

AHSA2 PSMB7 NFKBIAPSMA5 T, PSMA3 RIPK1 SLC7A11 P PSMB4 SCAP ARD6G, DOCK4 PSMB8PSMD1 PSMB9 PSMB10 F2R PSMD2 MITF IL1RAP IL1R2 TRAF2 LTA TNFRSF13C PSMB5 IRAK2 PFKFB3 ITGAL PSMB11 TNFRSF12A PSMB6 CRP TNFSF13B ASS1 CXCL13 IL1R2 ADORA2A TICAM1 CHUK FADD THBD TNFSF13B CARD8 IQGAP3 NFKB1 F5 IL1RN PSMD9 PSMA8 IL18BP MAP3K8IL23AIL2IL1R14 GPX5 PSMC5 DIABLO F7 NCR3 RELA FOSBJUND IFNG IL23R PSMB2 CD40LG BIRC2 PLA2G10 TRAF6CCR1 STIPTNIP1 1 F3 PSMD6 ADAM17 SLC7A1 CXCR4IKBKB NCOA1FOSL2 NCOA2 CD40 CXCL1 SHFM1 TRAF1 PTGES TRADD NRP1 CAT CSF2 PSMB3 PLA2G2C PLA2G4A F2 TAB2 CD80 APPSOCS3 IL10RA PSMD12 RELA NFKB2 Level 1 IRG1 HSP90AA1IRAK4 IL10 FOS CDC37 SOD3 PSMC4 F10 NCR3LG1 CASP1BIRC3 CXCL12 AR LIFR SLC2A3 PPBP IL23ACCL19 IL5 BIRC3 CCL4TNFAIP3 IL1B JAK2HSPA4CD28 GPX2 TNFSF12 TNF PLA2G1B EGF IL18 IL6ST STAT3GATA3 KIPLATTFOSL1F7GPX6 EREG PF4 CCR8 PSMA7 PSMD4 ALOX12 DARC BIRC2 CD289 CCR6JUNPLA2G4ANR3C1SOD1 PSMD7 PYCARD CTLA4 TLR4 IL2 GPX7ALOX5 TFPI CXCL6 TRAF3 VEGFA CSF3IL1A OSMIL6 THPO Level 1 CCL2 IL1B PSMD8 TRADD MAPKCCL5MAPK31 IL6 CCR7 PSMA1 MYD88 ATF3 STAT1NFKBIL6R 1 F2 ESR1FAS SERPINB8 DHRS9 STAT6 LTBR PSMD13 ALOX5 CYP2B6 PTGS2 TDO2 IL10 CD40 EGFR IL17A CXCR5 IRAK1IKBKG SERPINE1AKT1 PTGS2CXCL3 JUNPGFSOD2B CCL4 CCL21 CCR2 TRAF1 PLA2G5 FGG EMP2 CCL2OSMR0 CRP TNFRSF1EGFA KRAS GPX1 CXCL2 TRAF2 PSMC6 CD86 TNFRSF1VEGFAIL8 B MYC MAFF CCL25 HACE1 TNFRSF17 TNFRSF1B EPORCD40LGCD44 CXCL2IL4 NCOA3 NRP2 CCL5 F9 PTX3 TNF CSF3CEBPBRHIF1A NFE2 CCL11 CCBP2 CYP2E1 SERPINB9 KMO CASP8 NFKBIAIL12B MAPK8IP1 CXCL9IL8 CXCR3 IL1A NFKB1 AREG PLAUR TNFSF9CXCL1CCL23 TIMP1 STAT5B SERPINC1 IL10RA PSMA4 TNFAIP3 PLA2G2A IL36G F9 TNFRSF9 EPO F10 SLC39A8 ALOX15 SERPINC1 IL17RANAMPT FLT1 VTN CD47 IL18 RBCK1 HPGDS G0S2 CXCR6 IL2 IL4ICAM1 CXCR7 NLRP3 IL17ACXCL10 SELECCRL2 KDR MAPK8IP2 CCR3 UBE2N CYLD RNF31 SLC39A8 IL2RASTAT5A BMF CXCR1CXCR2 PTGES CCR5RBPJ CXCR2THBS1 F3ITGB8 PARD6B PARD3 CXCL5 PLAUPLG MMP9SPP1 SH3KBP1 CCR5 EIF4G1 SERPIND1 IL17RA IL4R MYO10 OLR1 IL4R CXCR1 IL1R2 ZHX2 CXCR4 TNFRSF13C VEGFB NFATC2 NFKB1 MAP3K8 CXCL12 PTGIS TFPI2 SERPINB2 RPS6 SLC3A2 CCL4L1 IL12RB1 TNFAIP6 CDH1 CCL20 PPAP2B UBE2D2 NTRK2 CCR1 TNF TFPI MAPK8IP3 TLR3 CASP1 BACE1 CXCL3 ETV6 RAF1 GPRC5A PTX3 AREG CYCS IL18RAP PKN2 PARD6G SLC7A11 SIRPA PRKCZ NTRK1NUMBTSC2 GFPT2 IL12B DENND4A IRS1SNAIEFNA31 EPHA6 KMO CCBL1 BIRC2 ITGB8MAPK10 ARHGDIARHGAP1A RICTOR TAB1 WNT5A PARD6A IGF1R AKT2EIF4A1 OTC LTA FASMYD88 PRKCI NOTCH3CDH2 PAK3 PIK3CBRPTORCCBL2 CASP3 PTEN PIK3CG UBE2D3 TICAM1 AXIN1 SOS1 MAPK8 DIABLO TGFBR1 ADK PFAS BCL2TNF B4GALT1 FLT4 CRKBDNF EGFR EIF4UGT1A1E NFKBIA SIRPA INSR MAPK7 IT FASLG IRAK4 BCAR1 CPS1 GB8, PLA NFKB2 SMURF2 PIK3CD HRAS CCL4, IL1A, IL1B TRADDREL CHUK IRAK1 EFNB3HSP90AA1PIK3CAEPHA2 GART RBCK1 UR, CD44 TRAF1 CASP8 IL18BP NET1 DPYSL5GSK3BNRASEPHB4 EPHB6AMPD3 HACE1 CTNNA1 PIK3R1MYO5C Level 1 ERBB2 NOTCH4GRB2 RHOA CYLD MAP2K4 ARHGEF1CBL 5 EGF DPYS CSF3 RELB TRAF3 RIPK1 LACC1 EPHAKDR3 EPHX1 RHEAFMIDHODBDH DOCK4 TNFAIP3 MAP3K8, CFLAR SHC1 EFNB1DPYSL3 INEPHA1SUMPS F10 TNFAIP3, IRAK2, TRAF1 BCL2L1 B3GALT2 DUSP1 SRC F7 TLR2 TNFRSF1A RPS6KB1 MAP2K7 NFKB1 F9 IRG1 LY96 NOTCH1DPYEPHB3D EPHA4 ACACA TRADD NCR3 F7 UBE2V1 BIRC3MAPK9 METNOTCH2 CDC42 GFPT1 RNF31 NFKB2 UBE2N IKBKB PAK1 FLT1 OXNAD1 COL5A1 IL1A F10 PEA15 LALBA RRAS EFNA5 CAD IL1RN CCL2 F2R BCL3 IL1R1 NFKBIB RASA1CRMP1 ACACB UBE2N TNIP1 BCL10 TNF IL1R2 SLC7A1 TLR4 RELA EPHB2 TRAF2 TNFSF9 IL18 JUN XIAP EPHA7CTNND1 PAK2 APRT IL12RB1 CRP EFNA2 DPYSLPAK74 DPYSL2 THBD IL23R BIRC2 SERPINC1 HPGDS GAB1ASS1 NFKBIA CCRL2 SLC39A8 NFKB1 IL1RAP SERPINB2 IQGAP3 TRAF6 EFNB2 ENSG00000251246PXNPSENCYB5R41 IL18 EGF TRAF2 DOCK1SPECC1LEFNA1 GSTT1 EIF4EBP1 BIRC3 F2 NCR3LG1 CCL23 CASP1 TLR6 CD40CD289 DIABLO CCR6 CD289 F3 TNFAIP3 EFNA4 PTX3 IL1B AREG CCR1 TIMP1 MAPK3 MAP3K7 EPHA5 NGEF IL17A TNFRSF13C TAB2 PLAU TAB2 NGFR PAK6 EPHB1 IL6 IL10 RELA TRAF6 STK38L SERPINB9 IL2RA SPP1 CRP IKBKG COL6A3 TRAF3 FGG Level 2 CD40LG CD40 TRADD SERPINB8 TNFRSF1B IL10RA IL5 TRAF1 TNF IKBKFASG IL4 CCL4 TNFRSF17 ADAM17 CXCL3 F2 FADD RIPK2 CD40 IL4CSF3RCXCL10 CD86 IL8 IL17A IL10RA CCL5 CXCR1 TNFSF13B TNFRSF1B PLG IL1R2 F3 MAP3K8 TFPI APP Level 2 IL4R TNFRSF9 CXCL1 IRAK4 TFPI2 IL23A DARC IKBKB VTN IL12B CSF2 MITF EGF IL36G IL1B IL4R CARD8 SELE FLT1 ICAM1 TNF CTLA4 IRAK1 TLR4 MYD88 SERPINE1 VEGFA IL23A TNFAIP3 STAT6 NLRP3 CCL4 IRAK2 TNFRSF1A EGFR THBS1 FOSB IFNG STAT1 BIRC3 MMP9 ITGAL IL17RA IL2 TRAF2 F9 JUND IL2 CCL20 CCR5 CD80 TRAF1 KDR OSMR IL10 CXCR2 RELA VEGFB IL1ACXCL2 IL1R1 RIPK1 CASP8 AREG TICAM1 PGF PLAT CD44 JUN CHUK IL24 CSF3 IL6R NFKB1 FADD BIRC2 KMO PYCARD IL1A, IL1B IL12B IL18BP PLAUR CD47 IL17RA NFKBIA FOSL1 ITGB8 TRADD GATA3 CL4 RNF31 SOCS3 TNF NRP1 C CD28 NRP2 ARHGDIA HACE1 LIFR AIP3, UBE2D2

CSF3 PXPAK7N BIRC3 PAK6ETV6 IRS1 GPRC5A EGF TRAF1 ITGB8, PLAUR, CD44 UBE2D3 NTRK1 NRAS MAPK7 TLR4 PTEN SNAI1 TLR6 PARD6G RAF1 DUSP1 IL12RB1 MAP3K8, IRAK2 FLTCB4 L HPGDS IL17RA IL1R2 ADAM17 VTN IFNG RBCK1 TAB2 CD40 TICAM1 PRKCZ RPS6KBRICTOR1 ARHGAP1 TNFRSF13C ITGB8 CHUK BCL3 PARD6B MAP2K7TGFBR1PIK3CB TRAF3 NLRP3 CHUK MAP3K8 TNFRSF1B CD47 NFKB1 SMURF2 IL23A TNF IL10 NFKB2 INSR IL5 AREG TICAM1 SLC39A8 TAB1 PIK3CD BDNF AKT2 Level 2 MYD88 SOS1CTNND1EGFPIK3R1R RHEBNOTCH1PAK1 ZHX2 NFKB1 CD44 TNFAIP3 WNT5A GSK3SRCB IGF1RCDH1 IL1R1 OSMR TNIP1 TNF TRAF2 SPP1 NFKBIA PARD6A CDH2 IKBKG TRAF1 IL8 RIPK1 IKBKB CDC4EIF4EBP12 IL23R TRAF6 TNFAIP3 LY96 ERBB2 HRAS EIF4G1RPS6 IL2 CSF3 TNFSF13B IKBKG UBE2NTAB2 EIF4E FLT1 CCL4 IL1B MITF NFKBIA TLR4 MET SHC1PIK3CA TRAF2 DIABLO Level 3 IL6R MMP9 TIMP1 AXIN1 EIF4A1 PTX3 IRAK1 BIRC2 TRADD PLAUR MAPK3 Level 3 NET1 NOTCH2 IL1RN VEGFA IL18BP MYD88 UBE2V1 PARD3 GAB1 CARD8 CD289 NTRK2 SH3KBP1 INS IL17A LIFR IKBKB EGF BCAR1 GRB2 IL10RA CRP IL23A TNFRSF1A FADD DOCK1 PSEN1 PYCARD APP PLAU TRAF6 NFKBIB TRAF3 MAPK10 CYLD CASP1 BIRC3 PIK3CGTSC2 CRK B4GALT1 BIRC2 IRAK4 CD289 CASP8 IQGAP3 HSP90AA1 STAT1 IL12B NOTCH4RPTOR JUND SIRPA KDCTNNA1R NOTCH3 IL18 KMO RIPK2 TLR3 TLR2 IL4R FOSB BCL10 IL10RA IRAK2 IL1RAP FAS RIPK1 JUN

IL1A IL1R2 RELA MAP3K7 TNF IL12B AREG IL24 NUMB PKN2 STAT6 FOSL1 IRAK1 BACE1 IL6 CSF3R SOCS3 TNF MAP3K8 IRAK4 DOCK4

C IL1B IRAK2 AIP3, IL1R1 P

CL4 CSF3 T ARD6G, ET ITGB8, PLA PRKCI LACC1 IL1A UR, CD44 TRAF1 BIRC3 RNF31 V6 IL18 MAP3K8 IL1R2 IL2 IL1R2 AREG DOCK4, ME EGF

NFKB1 IL1B TRADD TNF ITGB8 BDNF SNAI1 IL1B IL1A TRAF3 CDH2 IL1A Level 4 IL10RA NLRP3 AXIN1 CCL4 CD289 RIPK1 ETV6 IL12B NFKB1 TNIP1 SPP1 BCAR1 PXN CRK NOTCH2 KMO VTN IRAK4 BCL10 TLR2 CD289 ZHX2 CBL ADAM17 IRAK2 CASP8 SMURF2 EGFR DIABLO IL1RN BIRC2 CSF3 IL1R1 IL10RA IFNG IL1RN IKBKG GRB2 ARHGDIA KDR IFNG MAP3K8 TRADD Level 4 MAP3K8 CTNND1 TRAF2 TRAF6 TICAM1 ARHGAP1 NTRK2 SHC1 DOCK1 B4GALT1 FADD FAS IKBKG MAP3K7 WNT5ANOTCH1 PSEN1 Level 3 SOCS3 IL18BP TLR4 IL1R2 IRAK1 CD44 NFKB2 DOCK4 TGFBR1 NFKBIB HPGDS MET NTRK1 TAB2 PYCARD TNFAIP3 CTNNA1 CD47 HRAS PLAU BCL3 IRAK1 EGF ERBB2 STAT1 NFKBIA PAK6 FLT1 SRC PARD6G MYD88 CDH1 NFKBIA CHUK TRAF1 LACC1 PARD6A NOTCH3 IL1RAP PLAUR TLR6 NFKB1 NRAS SH3KBP1 IKBKB IRAK4 RELA GAB1 CDC42 NOTCH4 NUMB PLA SIRPA PARD3 TRAF1 PAK1 PARD6B

CSF3 IRAK2 IT UR, CD44 IKBKB FLT4 SOS1 AIP3 GB8 RIPK2 PIK3R1 PAK7 ET TNFAIP3 ME DOCK4, TRAF CHUK V6

MAP3K8

TRAF1 PLAU PRKCI ARD6G TRAF1 SPP1 P IKBKB NFKB1 CD289 RIPK1 RIPK1 RELA PLAUR

TICAM1 RELA ITGB8 T SOCS3 TAB2 TRAF6 Level 5 IL10RA

TRADD MAP3K8 IKBKG IRAK2 TRADD NFKB1 PSEN1 FADD CD44 MYD88 NUMB FADD VTN GAB1 SH3KBP1 B4GALT1 STAT1 TNFAIP3 CSF3 TLR4 TNFAIP3 MET IRAK1 CBL NFKBIA IRAK4 MAP3K8 TNFAIP3 NOTCH1 CHUK PARD6G NOTCH4 NOTCH2 Level 4 NTRK1 PIK3R1 EGF PARD6B BCL10 NOTCH3 NFKB1 SOS1 PARD6A CDH2 GRB2 EGFR FLT1 PARD3 CRK SMURF2 ETV6 KDR CHUK IKBKB WNT5A ERBB2

MAP3K7 SHC1 BCAR1 P ET

FLT4 ARD6G

DOCK4 V6 LACC1 RIPK2 PRKCI NFKBIB ME T DOCK4

NFKB1 CBL KDR PARD3 DOCK4 SOS1 CDH2 PARD6G CRK MAP3K8 NFKB1 EGFR SH3KBP1 Level 5

GAB1 ERBB2

TNFAIP3 IKBKB GRB2 MET ETV6 PARD6B

CHUK