ORGANIZING COMMITTEE AIM Paula Marques Alves This is an introductory course to Animal Cell Technology Animal Cell Technology Unit, IBET/ITQB-UNL, Apartado 12, (ACT), providing an overview of the field, from the more 2780-901 Oeiras, Portugal basic aspects to the final application. It should be of interest Tel.: +351 21 4469421 to those starting their research activity in ACT, both from E-mail: [email protected] Academia and Companies. It is also of interest for those wishing an up-date of the state-of-the-art of ACT in a short Francesc Gòdia course. ANIMAL CELL TECHNOLOGY Departament d’Enginyeria Química, Biològica i Ambiental, Escola d‘Enginyeria, Edifici Q, Universitat Autònoma de COURSE OUTLINE COURSE 2019 , Bellaterra, Barcelona 08193, Tel.: ++34 93 581 4790 After the interest received by the previous eight editions NINTH EDITION th E-mail: [email protected] and the excellent feed-back from the attendants, the 9 edition of the ACT course will be organized by the ESACT (European Society of Animal Cell Technology) in Llafranc, September 22nd - 26th , 2019 FEE and APPLICATION /Spain, from 22nd – 26th September 2019. ESACT is presenting this activity as one more contribution to the EUR 1000 for academic participants and EUR 1600 Llafranc, Costa Brava / Spain community involved in the use of animal cells in for industry participants . Biotechnology and Biomedicine. The fee covers course registration and materials (course The course is planned in an intensive four-day schedule book), accommodation in two-bed rooms (shared with with a number of participants limited to 30 in order to another participant), meals, transportation from/to facilitate the interaction among them and with the Barcelona airport (see the time schedule for the bus lecturers. Lecturers will stay for most of the course below). Participants have the possibility to be hosted in duration. The course comprises lectures covering the main single room (limited to availability) at an extra cost of 125 topics of Animal Cell Technology: Euros to be paid directly in the hotel. 1. Cell line development A limited number of grants , covering the course fee (not 2. Cellular mechanisms travel cost) , are provided by ESACT. Applicants to the grants 3. Omics analysis for systems biology of cells should indicate it in the course application, together with a 4. Post-translational modifications motivation statement. Priority will be given to young PhD 5. Bioreactor design 6. Bioreactor scale-up, scale-down and single use students from Academia . bioreactors 7. Downstream processing th All applications should be sent before 15 of June. 8. Integrated bioprocess for protein production Accepted applicants will be notified by July 10th and 9. Integrated bioprocess for stem cells should register and complete payment by August 15 th . 10. Economical aspects of ACT bioprocesses 11. Industrial perspectives of ACT

REGISTRATION and CONTACT The programme has slots dedicated to the preparation and presentation of case studies by participants and provides Photos: www.ibet.pt Updated information will be available at ESACT website time for discussion with the lecturers.

(www.esact.org ) With the contribution of: Final registration deadline is August 15 th , 2019. LECTURERS

Confirmed lecturers include Hansjörg Hauser (HZI,

Germany), Terry Papoutsakis (University Delaware, USA), Contact for registration: Manuel Carrondo and Paula Alves (iBET, Portugal), Francesc Birgit Marckhgott Gòdia (UAB, Spain), Stefanos Grammatikos (UCB Pharma, E-mail : [email protected] Belgium) and Anne Tolstrup (BioProcess Technology

Group/BDO, USA).

Further information can be found at: www.esact.org PROGRAMME

Sunday Monday Tuesday Wednesday Thursday Time 22nd Sep 23 rd Sep 24th Sep 25th Sep 26th Sep 9.00 Introduction of course Omics analysis for systems Bioreactor scale -up Integrated bioprocess - participants biology of cells (I) and scale-down for protein production 10.00 presentation H. Hauser S. Grammatikos A. Tolstrup 10.00 Omics analysis for systems Miniaturized and Integrated bioprocess Overview Lecture - biology of cells (II) Single-Use Bioreactors for stem cells M. Carrondo ACT course 2018 11.00 H. Hauser S. Grammatikos P. Alves Coffee break 11.30 Post-translational Industrial perspectives Cell line development (I) Downstream processing (I) - modifications (I) of ACT H. Hauser M. Carrondo 12.30 E. Papoutsakis A. Tolstrup Arrival to 12.30 Cell line development Post-translational Barcelona/ Downstream processing (II) - (II) modifications (II) Wrap-up session M. Carrondo 13.30 airports and H. Hauser E. Papoutsakis transfer to Lunch and Free time 15.30 Integrated bioprocess for cell Hotel Cellular mechanisms (I) Bioreactor Design (I) - culture-based vaccines Terramar in E. Papoutsakis F. Gòdia 16.30 Llafranc P. Alves Coffee break ACT course 2017 Check-in 17.15 Economical aspects of Hotel Cellular mechanisms (II) Bioreactor Design (II) - ACT bioprocesses Course adjournment, E. Papoutsakis F. Gòdia 18.15 A. Tolstrup hotel check-out and Tes monials of ACT Course Par cipants departure to

Barcelona/Girona “ The organiza on of the course was “ A very well organized and 18.30 Introduction / airports excellent. The lecturers and all Study case / progress Study case / final discussion par cipants were coopera ve, sensible balanced course that - Study case presentation and suppor ve. I enjoyed the course. “ enabled me to refresh discussion S. Grammatikos some basic cell culture 19.30 S. Grammatikos concepts and to learn about Robert Beck some of the latest Free time Private researcher, Germany innova ons in the field, and all this in a very friendly Welcome atmosphere and a beau ful 20.30 Dinner “ The ESACT course in environment! ” and dinner Llafranc was a great opportunity to improve Boris FESSLER my knowledge in the UCB Pharma, Belgium Biotechnology area. The professors were very a en ve and the structure of the course “ The leveling-board lies very high. I really want to LOCATION AND TRAVEL INFORMATION was very organized, thank ESACT and all the people involved in providing us comfort organizing that course, it was brilliant joining you. " and tranquility to enjoy The course will be held in Hotel Terramar, a 3-star hotel (www.hterramar.com) in a small Sebas an Schwamb the lectures. “ PhD Student, Germany town named Llafranc in the heart of Costa Brava, Girona, Spain. The hotel is right on a Renata Alvim very nice sandy beach, providing a cosy and relaxing atmosphere for the participants. Biotechnology technician, Brazil ” I felt that the 2013 ESACT Weather in Llafranc at this time of the year is generally pleasant. Travel organization to ACT course gave me much LLAFRANC needed insight into several the meeting is of participants responsibility, ensuring their participation to the full “I had the opportunity to improve my aspects of Bioprocess knowledge in the Biotechnology field. It Engineering, and for me, as an was a great opportunity to interact with course. Access by road from Girona airport (30 min) or Barcelona airport (90 min) is academic researcher, the the most important researchers in this opportunity to interact with suggested. IMPORTANT NOTE: ONE BUS will be leaving from Barcelona airport at 18h area. The professors always were very scien sts and engineers on Sunday 22nd September to drive participants to Hotel Terramar at Llafranc. On Thursday 26th September, ONE BUS will be leaving from a en ve and the lectures were excellent.“ working in industry was invaluable. " Hotel Terramar at 15h to drive participants to Barcelona airport. Participants should arrange their travelling accordingly or alternatively André Luís Inocencio Steve George arrange for their transportation on their own. Master Student, Brazil Graduate Student, Canada