Supplement, Table 13. affected by Celecoxib which products are involved in focal contact formation UniGene Cluster HUGO Geometric Parametric p- Effect on Reference ID Symbol mean of value Focal ratios P/F Contacts

Hs.334131 CDH2 2, type 1, N-cadherin (neuronal) 0.677 0.0028 Negative (1) Hs.423 PAP pancreatitis-associated 0.683 0.0040 Negative (2) Hs.83572 PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.752 0.0005 Unknown (3) (Noonan syndrome 1)

Hs.75445 SPARCL1 SPARC-like 1 (mast9, hevin) 0.758 0.0020 Negative (4)

Hs.272311 EPHB1 EphB1 0.767 0.0430 Positive (5) Hs.89436 CDH17 cadherin 17, LI cadherin (liver-intestine) 0.774 0.0017 Unknown (6) Hs.3260 PSEN1 presenilin 1 (Alzheimer disease 3) 0.778 0.0067 Positive (7) Hs.74561 A2M alpha-2-macroglobulin 0.78 0.0109 Negative (8) Hs.173548 NRP1 1 0.784 0.0075 Unknown (9) Hs.436042 CXCL12 chemokine (C-X-C motif) ligand 12 (stromal cell-derived 0.788 0.0189 Positive (10) factor 1)

Hs.128087 F2R coagulation factor II (thrombin) receptor 0.815 0.0045 Positive (11) Hs.170560 VIPR2 vasoactive intestinal peptide receptor 2 0.82 0.0992 Positive (12) Hs.443811 CALD1 caldesmon 1 0.821 0.0277 Negative (13) Hs.324473 MAPK1 mitogen-activated protein kinase 1 0.828 0.0248 Unknown (14) Hs.69429 TSC1 tuberous sclerosis 1 0.83 0.0073 Positive (15) Hs.118400 FSCN1 fascin homolog 1, -bundling protein 0.846 0.0094 Negative (16) (Strongylocentrotus purpuratus)

Hs.9691 GNA13 guanine nucleotide binding protein (G protein), alpha 1.148 0.0153 Positive (17) 13

Hs.446394 BCR breakpoint cluster region 1.177 0.0152 Unknown (18) Hs.1721 IL11 interleukin 11 1.184 0.0337 Positive (19) Hs.441044 EDIL3 EGF-like repeats and discoidin I-like domains 3 1.204 0.0165 Positive (20)

Hs.461934 SPN sialophorin (gpL115, leukosialin, CD43) 1.213 0.0112 Unknown (21) Hs.253309 PTEN phosphatase and tensin homolog (mutated in multiple 1.22 0.0092 Unknown (22) advanced cancers 1)

Hs.397624 MGAT5 mannosyl (alpha-1,6-)- beta-1,6-N-acetyl- 1.229 0.0099 Negative (23) glucosaminyltransferase Hs.652 TNFSF5 tumor necrosis factor (ligand) superfamily, member 5 1.236 0.0091 Positive (24) (hyper-IgM syndrome)

Hs.73917 IL4 interleukin 4 1.256 0.0551 Positive (25) Hs.54460 CCL11 chemokine (C-C motif) ligand 11 1.258 0.0105 Positive (26) Hs.2561 NGFB nerve growth factor, beta polypeptide 1.293 0.0294 Positive (27) Hs.7019 SIPA1 signal-induced proliferation-associated gene 1 1.299 0.0100 Negative (28)

Hs.194657 CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.31 0.0065 Unknown (29) Hs.440898 FCN1 ficolin (collagen/fibrinogen domain containing) 1 1.325 0.0202 Unknown (30)

Hs.53973 VIP vasoactive intestinal peptide 1.382 0.0600 Positive (31) Hs.1741 ITGB7 , beta 7 1.396 0.0057 Positive (32) Hs.353214 ICAM3 intercellular adhesion molecule 3 1.457 0.0140 Unknown (33) Hs.82848 SELL L (lymphocyte adhesion molecule 1) 1.463 0.0522 Positive (34)

Hs.387725 ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 1.47 0.0258 Positive (35) receptor)

Hs.89679 IL2 interleukin 2 1.49 0.0292 Positive (36) Hs.171596 EPHA2 EphA2 1.571 0.0020 Positive (37) Hs.376208 LTB lymphotoxin beta (TNF superfamily, member 3) 1.719 0.0043 Positive (38)

Hs.1498 HRG histidine-rich glycoprotein 1.754 0.0012 Positive (39) Hs.243491 CASP8 caspase 8, apoptosis-related cysteine protease 1.884 0.0003 Unknown (40) References (Supplement, Table 14)

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