National Research Activity International Research Activity Research Programmes Research Reports Staff of Pusat Pengimejan Diagnostik Nuklear 2012 - 2013

Back row (from left): Rosnawati, Nur Hafizah, Komaty, Amar, Ismarezzal, Hafizi, Rosli Front row( from left): Shahrin, Fathinul Fikri, Abdul Jalil, Nasrudin, Hishar Not in the image: Amir, Kasbillah, Suhayu, Salasiah

ISSN: 977-2289-520005 ANNUAL BOOK 2012 (Research Activities & Output)

Cetakan Pertama/First Printing, 24-10-2013 Hak Cipta/Copyright Pusat Pengimejan Diagnostik Nuklear, Universiti Putra Malaysia

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Diterbitkan di Malaysia/Published in Malaysia by

PUSAT PENGIMEJAN DIAGNOSTIK NUKLEAR UNIVERSITI PUTRA MALAYSIA 43000 SERDANG, SELANGOR

Abdul Jalil Nordin Shahrin Samat Fathinul Fikri Ahmad Saad Hishar Hassan Rosli Md Yusof iii Research Activities and Outputs 2012-2013

Words From In the 2012, The Pusat Pengimejan Diagnostik Nuklear would be two years old, and we are pleased to introduce the 3rd issue of the Annual The Director Book 2012 in celebration.

It is due to the dedicated efforts by our local researchers and collaborators that our agenda is attracting high quality research works and the effort is becoming more and more crystalised amongst our molecular profession peers.

This book edition offers a valuable documentation on our achievement across the year of 2012 which highlights examples from actual scientific sessions by us, our fellow collaborators, student held nationally and internationally. In other words, it addresses the exemplary works towards ameliorating research in translational imaging which offers another journey in the personalized medicine era.

Prof. Dr. Abdul Jalil Nordin At this point in time, quality becomes a dominant factor of our success MID UKM, M Med Rad UM in every means and ways, we are leaping forward without exclusion of Fellowship NMed (Sydney, AUS) our constant commitment with the related industry and communities Fellowship PET CT (Zurich, in the provision of education. SWISS) Preceptorship Cardiac PET I thank all the contributing efforts by parties for their exceptional (Cleveland, USA) works on behalf of PPDN.

Your endless efforts and continuing support have enabled us to move forward to achieve ‘high centre of excellence’.

I wish you all the best.

‘With Knowledge We Serve’

Prof. Dr. Abdul Jalil Nordin Director International Research Activities : Research Technology iv

Associate Council Members

Rosetti Claudio Director and Associate Professor Nuclear Medicine and PET/CT Centre, Ospedale Niguarda Ca’ Granda, Piazza Ospedale Maggiore 3,Milan 20126, Italy

Roger I Price (MACPSEM) Head, Department of Medical Technology & Physic and RAPID PET Laboratories Sir Charles Gairdner Hospital Adjunct Professor in School of Physics, University of Western Australia Perth, Western Australia

W F Eddie Lau Director of Clinical, PET Centre for Cancer Imaging The Peter Mac Callum Cancer Centre, Univ. of Melbourne Australia

Prof (M) Dr Abdul Rahman Mohamad Adjunct Professor in Nuclear Medicine Centre for Diagnostic Nuclear Imaging Faculty of Medicine & Health Sciences Universiti Putra Malaysia

v Research Activities and Outputs 2012-2013

Associate Council Members

Dr Noraini Abdul Rahim Consultant Radiologist National Cancer Institute, Putrajaya, Malaysia

Prof (M) Dr. S.T. Subha Consultant ENT Surgeon International Medical University Malaysia (IMU)

Dr. Ahmad Fazli Bin Abdul Aziz Interventional Cardiologist Faculty of Medicine & Health Sciences Universiti Putra Malaysia

Dr. Ahmad Hisham Bin Abd. Rashid Orthopedic Surgeon Faculty of Medicine & Health Sciences Universiti Putra Malaysia

Assoc. Prof. Dr. M. Iqbal Bin Saripan Associate Professor Faculty of Engineering Universiti Putra Malaysia

Research Activities and Outputs 2012-2013 iv

Editorial Team Editorial Preface

It is my privilege to welcome you to the insight of the year-round activities and achievement of the Pusat Pengimejan Diagnostik Nuklear, UPM.

It gives us immense pleasure to see PPDN grows by leaps and bounds, and become stronger with each passing day.

Efforts will be made to envisage connections to national and Chief Editor international programmes in the field of research and mobility, Dr Fathinul Fikri AS which will support molecular imaging as the most challenging era in medical imaging.

This 3rd issue of the annual book highlights multidisciplinary contents, which include continual substantiation of our research activities and hence the yearly research report.

At the end of this preface, I would like to take the opportunity to extend my sincere acknowledgement to all the collaborators and supporting staffs of PPDN, for extending their kind support and co-operation which truly helped PPDN to grow and become as Associate Editor successful as it is today. Dr Shahrin Samat The Editor is indebted to his co-Editors on the continual support in making this issue a useful feat. Some small adjustments have been made in the interests of a more rapid generation of material of this publication.

Any remaining errors and infelicities are his alone

I wish you all the best.

Associate Editor Sincerely, Hishar Hassan

Chief Editor

Copy Editor Rosli Md. Yusuf

National Research Activity International Research Activity Research Programmes Research Reports

Table Of Contents

National Research Activities 1

International Research Activities 5

Research Programmes 9

Research Reports 19 NATIONAL RESEARCH ACTIVITIES

Conferences MOHE grant meeting PET/CT workshop Research Awards 12 Research Activities and Outputs 2012-2013

Mini Symposium on Biotracer Annual Scientific Meeting of Discovery: from bench to the College of Radiology bedside 30th Mar - 1st Apr 2012 23 June 2012 The annual Scientific Meeting of the College of Radiology provided one of the most important opportunity in showcasing excellence and innovation in Cancer Imaging. The conference committee had put together a very interesting program that could cater for the different needs of the radiologists and radiographers. The program also provided opportunities to network, exchange information, resources and ideas and to explore new and innovative work. There were series of seminars organised by 5 The symposium was aimed at formulating different Special Interest Groups (SIG) - Head a common research theme in Molecular & Neck, Paediatrics, Musculoskeletal, Body Imaging whereby the development and use of Imaging and Interventional Radiology. A free oral positron emission tomography (PET), for in vivo paper presentation was also held with 9 papers functional imaging of tumours can be utilized presented. Associate Professor Dr. Ng Chaan for the cutting edge research. Most of the from MD Anderson gave a tutorial for those lectures in the event highlighted the benefits taking their Fellowship of the Royal College of of the technology employing SUV (quantitative Radiologists, UK or the Masters (Radiology) method) of different tumour biology in human Programme, which was well attended by more subjects as a method of research in presurgical than 20 trainees. Our fellow researcher, Prof. staging of tumour, treatment monitoring, Dr. Abdul Jalil Nordin bagged in silver medal localization of tumour recurrence , prediction for his outstanding performance in an oral of tumour aggressiveness and prognostication presentation. of patient survival. Alongside PET, there was also discussion on the role of other molecular Achievement: imaging technique employing high resolution Achievement: Participated by PPDN members quantitative autoradiography study i.e mRNA for F.Fathinul, Zanariah H, AJ Nordin. preclinical and basic imaging research, with a Localisation and prediction of recurrent focus on early clinical translational studies. Phaeochromocytoma/ Paraganglioma(PCC/ PGL) using diagnostic 18[F]FDG-PET/CT- The event was officiated by Prof. Dato’ Ir. Dr. Poster Mohd Saleh Jaafar, the Deputy Vice Chancellor F.Fathinul PET-CT in Neuroendocrine Tumour . (Research and Innovation) and was attended by Guest Speaker more than 50 scientific research collaborators Sethu Thakachy Subha , Fathinul AS, Saraiza from various biomedical disciplines. Abu Bakar, Muhamad Azrif , Abdul Jalil Nordin. The Clinical Outcome of head and Achievement: neck malignancy patients using integrated Formation of a translational Research Group in Positron Emission Tomography Computed Molecular Imaging, UPM senate has approved Tomography - an initial experience: Oral a research programme in Molecular imaging in Presentation: early 2013. Abdul Jalil Nordin, Noraini Abdul Rahim, Fathinul AS.Mediastinal mass sampling at percutaneous PET-CT guided biopsy : setting a new course in patient management after multiple futile biopsies: Poster Research Activities and Outputs 2012-2013 3

National Conference on Malaysian Endocrine Society Physic 2012 (PERFIK), Colmar Annual Congress Tropicale, Bukit Tinggi, 24th - 27th May 2012 Pahang 19-21st November 2012

The conference featured several distinguished speakers who had shared their expertise, and perspectives in various areas of mutual relevance. Apart from updating PERFIK 2012 aimed to promote scientific endocrinologists, physicians, trainees and collaboration and research findings among medical officers in the rapidly growing field of scientists and industries involved in various endocrinology and metabolic medicine, the aspects of basic and applied physics. The Congress had also served as an occasion conference was held in Colmar Tropicale, Bukit where collaborative works in various fields of Tinggi, Pahang between 19th to 21st November medicine had taken place to enhance scientific 2012. Young researchers, participants from knowledge in the field of endocrinology in industries, universities, governmental research particular. The congress was aimed at putting institutions, postgraduate students and a strong emphasis on current topics in the interested parties were presented at the event. diagnosis and management of endocrine There were about 80 papers presented during disorders. Molecular imaging in malignant the oral parallel presentation. phaechromocytoma –paraganglioma was a theme for a poster presentation represented Participated Researcher: by our research collaborator- Dr Teik Hin Tan Hishar Hassan (National Institute of Malaysia) had added in a new perspective the evaluation of such cancer Achievement: whereby the use of a new 68 Ga-DOTATATE Hishar Hassan, AS Fathinul Fikri, M Salasiah, PET/CT was compared with 18F-FDG PET/CT MN Noramaliza, N Abdul Jalil. Association of on the overall accuracy performance. total activity 18F-FDG injected with the overall PET image quality in oncology patient: Oral Partcipated Researcher: Presentation. The abstract is published in a Research collaborator PERFIK 2012 proceeding book. Achievement: Meanwhile the full paper entitled Impact of total Teik Hin Tan, Boon Nang Lee, Fathinul Fikri activity variation in 18F-FDG injected with the Ahmad Saad, Zanariah Hussein. Comparison overall PET image quality in oncology patients the effectiveness of 131 I-MIBG scintifraphy, has been selected for publication in peered 68 Ga-DOTATATE PET/CT and 18F-FDG PET/ reviewed AIP Conference Proceeding (SCOPUS CT in mapping malignant phaechromocytoma cited). and paraganglioma- Putrajaya experience,- published in the Journal of Endocrine and metabolism (Poster: selected for publication in the Journal of Endocrine and Metabolism). 14 Research Activities and Outputs 2012-2013

Pameran Rekacipta Penyelidikan dan Inovasi Malaysia, (PRPi),UPM 19-21 July 2012

Participated Researcher: Dr Fathinul Fikri AS

Title: F.Fathinul, Zanariah H, AJ Nordin Localisation and prediction of recurrent Phaeochromocytoma/ Paraganglioma(PCC/PGL) using diagnostic 18[F]FDG-PET/CT

Achievement: Poster Presentation (Silver Medal) INTERNATIONAL RESEARCH ACTIVITIES

Conferences / Summits Scientific Visits International Networking Refresher Courses 16 Research Activities and Outputs 2012-2013

The Health Seminar, USIM 19th-20th May 2012 The health seminar of Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia (FPSK, USIM) was an international scientific event held annually since the year 2006. The aim of the programme was to foster professional knowledge and enhance research in the field of medicine, with Islam as the foundation.

Attendees to this event were amongst local health professionals, international researchers and medical personnel especially from Islamic countries. USIM’s 1st International Conference on Medicine and Health stimulated new scientific enquiries and academic discourse relating to health issues according to the perspective of the Muslim ummah.

Achievement: Syafinaz Amin Nordin, Faridah Idris, Malina Osman, Rukman Awang Hamat, Fadzillah Ghazali, Fathinul AS. Refusing vaccines, they are not the odd ones out: Poster: Silver medal

Annual Congress of the European Association of Nuclear Medicine , Milan, Italy October 27 – 31, 2012 The European Association of Nuclear Medicine (EANM) is the umbrella organisation of nuclear medicine in Europe and represents the sector towards the European Institutions. Within this role, the EANM aims at advancing science and education in nuclear medicine for the benefit of public health as well as at promoting and co-coordinating, throughout Europe and beyond, discussion and exchange of ideas and results relating to the diagnosis, treatment, research and prevention of diseases through the use of unsealed radioactive substances and the properties of stable nuclides in medicine.

The goal of the EANM is thus to provide a suitable medium for the dissemination and discussion of the latest results in the field of nuclear medicine and related subjects. Prof. Dr. Abdul jalil Nordin had successfully presented four scientific posters in the field of molecular imaging.

AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA NA Rahim, AS Fathinul Fikri, AZF Azman, Rahim, AS Fathinul Fikri, AZF Azman, C Rossetti. C Rossetti. *The value of functional imaging in *The performance of nicotinic acid in shifting monitoring anti-tuberculosis treatment using myocardial metabolism to glucose in 18F-FDG PET in comparison to morphological 18F-labeled 2-deoxyglucose (FDG) PET-CT 3-dimensional CT changes. myocardial viability assessment. AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA AJ Nordin, Agnese, L Deciolo, NA Rahim, AS Rahim, AS Fathinul Fikri, AZF Azman, C Rossetti. Fathinul Fikri, AZF Azman, C Rossetti. *State of *Multimodality imaging PET-CT using 18F-labeled the art PET-CT technique;one-stop percutaneous 2-deoxyglucose (FDG) ensures effective treatment PET-CT guided biopsy : a new local experience. delivery by improving the staging of head and neck malignancy

Participated Researcher: Prof. Dr Abdul Jalil Nordin

Achievement: All abstracts presented in the conference are published in Journal of Nuclear Medicine and Molecular Imaging (IF 5.5) Research Activities and Outputs 2012-2013 7

CN192 International 12th Annual Teaching Course Conference on Radiation and International cancer Protection in Medicine Bonn, imaging Society Meeting, Germany Oxford, UK 3-7 December 2012 4th-6th October 2012

35 participants representing 77 Member States and 16 organizations attended the Conference, which was held at the World Conference Center, Bonn (the former federal government Plenary Chamber).

Prof. Dr. Abdul Jalil Nordin attended the meeting as a mission to promote and expand the Solving problems in cancer patients molecular imaging agenda pioneered by PPDN The twelfth annual teaching course had focused in Malaysia. on ‘solving problems in cancer patients’. Content had structured around clinical and technical stumbling blocks met in everyday Achievement: practice and offer solutions to these issues. International Research Networking Achievement: Fathinul AS , AJ Nordin, R Dharmendran, P Vikneswaran . The value of pretreatment PET-CT in predicting survival in patient with esophageal cancer. Abstract is published in the Cancer Imaging Journal (IF. 1.5). 18 Research Activities and Outputs 2012-2013

The 68th Korean Congress of Radiology 18th-20th October 2012 Abdul Jalil Nordin1, Wan Azman Wan Ahmad2, Fathinul Fikri Ahmad Saad1, Ahmad Zaid Fattah Azman1, Abdul Latiff Mohamed3 1Universiti Putra Malaysia, 2Universiti Malaya, 3Cyberjaya University College Medical Science, Malaysia. [email protected]

SE 14 OT-09 The effect of contrast-enhanced CT in integrated 18F-FDG PET/CT imaging of cancer patient

Mohd Hafizi Mahmud1, Abdul Jalil Nordin1, Fathinul Fikri Ahmad Saad1, Ahmad Zaid Fattah KSR opened its Congress to the international Azman2 1Diagnostic Nuclear Imaging Centre, audience in 2007, and since then the number Universiti Putra Malaysia, 2Universiti Putra of sessions operated in English has increased Malaysia, Malaysia. [email protected] to over 70% of the whole program. The conference had designed a program with high quality scientific sessions for which it had successfully provided a great opportunity for all participants to keep up-to-date with the latest research findings. The conference had featured delegates of more than twenty world renowned scholars from 12 countries. Among them, Dr. Gabriel P. Krestin, who is the current president of ESR, will give the Congress Lecture.

Participated Researcher: Prof. Dr. Abdul Jalil Nordin and Mohd Hafizi Mahmud At the Korean Congress of Radiology, the organiser has chosen the above photographic Achievement: shot as the best academic photo exhibition for International Research Networking. the Academic photographic contest as a side Presented posters (published in the proceeding event held in parallel with the main scientific book) congress

SS 06 CV-01 09:40 Winner of photo contest at the KCR 2012. The value of quantifying myocardial flow reserve in relation to left ventricular function on myocardial perfusion PET-CT using Achievement: 82Rubidium Prof Dr Abdul Jalil Nordin bagged in USD 500 as a scientific grant. RESEARCH PROGRAMMES

Oncology Cardiology Infection 10

RESEARCH ECOSYSTEM Programme: Molecular Imaging (HWB 07) Synopsis In the past decades, we have witnessed the importance of non communicable diseases including coronary artery diseases, malignancy and cerebro-vascular diseases as the main cause of death in Malaysian hospitals. Molecular imaging is a new field in medicine characterizing, and quantifying the biological processes at the cellular and subcellular levels within intact living organisms. The field exploits specific molecular probes as the source of image contrast where it provides the imaging signal in almost all molecular imaging assays. The development, validation, and application of this novel imaging technique in living subjects should further enhance our understanding of disease mechanisms and go hand in hand with targeted personalised therapy. The findings can be correlated with gene expressions and the discovery of novel biomarkers with potential utilization in drug discovery.

Research Structure

Research Administrator (RMC)

Molecular Imaging Prof. Dr Abdul Jalil Nordin (Coordinator:Dr Fathinul Fikri A.S)

Molecular Genetic & Genomic Cell Biology & Immunohistology Assoc. Prof. Dr Cheah Yoke Assoc. Prof Dr Shiran Kqueen Mohd Sidek

Biomedical Science (Animal Imaging and PET laboratory Technologies) Hishar Hassan

Science Physic Assoc. Prof. Dr. M. Iqbal Saripan Research Activities and Outputs 2012-2013 11

Molecular Genetic and Genomic

Researcher Profile: Assoc. Prof Dr Cheah Yoke Kqueen Specialization : Bioinformatic and Genetic Field of interest : Biomedical Science

Collaborator Profile: Dr Tiffany Ng Shi Yeen Master Student

Synopsis: Achievements: Somatic mutations of the EGFR gene are Nor Asmara Tasrip, Mohd Nasir Mohd valuable biomarkers for NSCLC patients. It has Desa, Cheah Yoke Kqueen, Chong Pei Pei, Mar- been reported that EGFR mutations were more iana Nor Shamsudin frequently detected in selected sub-population Associations between Cultural Characteristics of patients with the following characteristics and Antibacterial Activities of Streptomyces – female gender, adenocarcinoma histology, Isolates: A Preliminary Analysis4th International Asian origin and non-smokers. Better clinical Conference on Biomedical Engineering in Viet- responses to tyrosine kinase inhibitors (TKIs) nam were observed in this particular group of IFMBE Proceedings Volume 40, 2013, pp 135- patients compared to its counterpart. Thus, 136 EGFR mutation testing is now a standard in the management of advanced lung adenocarcinoma in many of the western countries and in some countries and medical centers in East Asia. In Malaysia, lung cancer is the second most common type of cancer among men and ranked sixth among women. As a multi-racial Asian country, Malaysia is comprised of various ethnics. Therefore, we aim to detect major EGFR mutations in FFPE specimens and examine the associations between the mutations and ethnicity, patient’s gender, age at diagnosis, tumor histology, clinical stage, and smoking history. 121 Research Activities and Outputs 2012-2013

Molecular Imaging (Oncology)

Researcher Profile: Dr Fathinul Fikri Ahmad Saad Specialization : Radiologist Field of interest : Oncology Imaging

Collaborator Profile: Dr. Zanariah Hussein Specialization : Endocrinologist Field of interest : Endocrinology

Synopsis: Achievements: Pheochromocytomas are also referred to as Localisation and prediction of recurrent adrenal paragangliomas. Paragangliomas Phaeochromocytoma/ Paraganglioma(PCC/ originate from the neural crest-derived PGL) using diagnostic 18[F]FDG-PET/CT paraganglia of the autonomic nervous system. Accepted Original Article in Journal of Acta These tumors originate from catecholamine- Radiologica (IF:1.3) producing chromaffin cells. The increased glucose uptake imaged with Flurodeoxyglucose Positron Emission Tomography (FDG PET) is largely dependent on the rate of glycolysis. FDG uptake and trapping occurs because of upregulation of glucose transporters (notably GLUT1 and GLUT3) and HEXOKINASES I and II . FDG PET imaging also allows quantification of glucose uptake. It is known that in many studies, poor disease prognosis is consistently correlated with increased tumour inherent increased glucose uptake in tumours Research Activities and Outputs 2012-2013 13

Biomedical Science (Cyclotron, Radionuclides Production & Radiopharmaceuticals)

Researcher Profile: Muhamad Hishar Hassan Specialization : Radionuclides production, radiopharmaceuticals and cyclotron

Collaborator Profile: Dr. Roger Price Specialization : Medical Physicist Field of interest : Cyclotron, Production of Radionuclides and Radiopharmaceutical

Synopsis: Achievements: In view of increasing significance of Hishar H, AS Fathinul Fikri, M Salasiah, MN radiopharmaceuticals in medical diagnosis, Noramaliza, N Abdul Jalil. Impact of Total Activ- niche area of cyclotron, radionuclides ity Variation in 18F-FDG Injected with the Overall production and radiopharmaceuticals PET Image Quality in Oncology Patients” has possesses an important element in nuclear been accepted for publication in American Insti- medicine diagnosis. The physician, specifically tute of Physics (AIP) the oncologists are no longer preferred the conventional ubiquitous radiopharmaceutical 18F-FDG. New radiopharmaceuticals emerge one after another that are able to provide high sensitivity and specificity when approaching a very specific oncology type disease. Hence, the ability to explore new radiopharmaceuticals either from charged-particle accelerator (cyclotron) or generator, 18F-fluorine based or non- 18F-fluorine based is essential in assisting management of nuclear medicine diagnosis. 141 Research Activities and Outputs 2012-2013

Science Physic (Physic and Radiation Protection)

Researcher Profile: Salasiah Mustafa Specialization : Science Physic Working Experience : 6 years Field of interest :Science Physic

Collaborator Profile: Prof. Dr. Abdul Jalil Nordin Specialization :Nuclear Radiology Working Experience : 15 years Field of interest : Cross Sectional Integrated Nuclear Radiology in cardiology, neurology and infection

Synopsis: Achievements: PET CT is a combined multi-modality Salasiah M, AJ Nordin, AS Fathinul Fikri, H imaging that provides anatomical locations Hishar, N Tamchek, K Taiman, AK Ahmad BAzli, and functional imaging. The commonly HA Abdul-Rashid, GA Mahdiraji, R Mizanur, MN radionuclide used is 18F-FDG ~short half-life Noramaliza (110min). Radioisotope consists of unstable Radiation Dose To Radiosensitive Organs In nucleus. Therefore, it will decay to achieve PET Myocardial Perfusion Examination Using stable configuration of proton and neutron. Versatile Optical Fibres. SPIE 8775, Micro- During radioactive decay, an unstable nucleus structured and Specialty Optical Fibres II, spontaneosly decomposes to form a different 87750U (May 3, 2013); SPIE Conference Rep. nucleus, giving off radiation in the form of Chezk (2013)- Poster Presentation atomic partices or high energy rays. This decay occurs at a constant, predictable rate that is referred to as half-life.

Research Activities and Outputs 2012-2013 15

Molecular Imaging

Researcher Profile: Prof. Dr. Abdul Jalil Nordin Specialization :Nuclear Radiology Working Experience : 15 years Field of interest : Cross Sectional Integrated Nuclear Radiology in cardiology, neurology and infection

Collaborator Profile: Prof Dr Maria Carla Gilardi Specialization : Nuclear Medicine and Radiopharmaceutical

Synopsis: Achievements: Shazreen Shaharuddin, Ahmad Zaid Fat- The program is developed with the following tah Azman, Katiza Haida Ali, Abdul Latif Mo- objectives : hamad, FathinulFikri Ahmad Saad, Abdul 1. Investigating the role of 18F-FDG PET-CT in Jalil Nordin Vulnerable plaque detection: The dementia and vulnerable plague role of 18-fluorine fluorodeoxyglucose in iden- 2. Developing normal ASIAN database for tifying high risk patients. Alexandria Medical Statistical Parametric Mapping analysis, 3. Journal. 2013. 49(3). In press Highlighting the potential of 18F-FDG in other clinical conditions , 4. Incorporating 18F-FDG into routine clinical practice where indicated. 161 Research Activities and Outputs 2012-2013

Science Physic

Researcher Profile: Mohd Hafizi Muhamad Specialization : Science Physic Working Experience : 6 years Field of interest : Molecular Imaging

Synopsis: Achievements: To evaluate the effect of intravenous contrast The effect of contrast-enhanced CT in media during integrated Positron Emission integrated 18F-FDF PET/CT imaging of cancer Tomography Computed Tomography (PET/CT) patient. Mohd Hafizi Mahmud, Abdul Jalil using fluorine-18 fluorodeoxyglucose (18F-FDG) Nordin,FathinulFikri Ahmad Saad, Ahmad Zaid as tracer in cancer imaging. Fattah Azman: Poster presentation at KCR 2012. This study demonstrates that application of contrast-enhanced CT in PET/CT imaging of cancer patient will cause significant changes on CT values but no significant changes on SUVmax values. Research Activities and Outputs 2012-2013 17

Molecular Imaging (Myocardial Viability and Perfusion)

Collaborator Profile: Prof Dr Abdul Latif Mohammad MD Cardiologist, Cyberjaya Univ College Med Sciences

Dr Christian Pirich (MD) Nuclear Medicine. Paracelsius Medical University Salzburg , Austria

Synopsis: Achievements: AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, The program is developed with the following NA Rahim, AS Fathinul Fikri, AZF Azman, C objectives : Rossetti. *The performance of nicotinic acid in 1. Developing normal LV polar map database for shifting myocardial metabolism to glucose in Asian population to be utilized for interpreting 18F-labeled 2-deoxyglucose (FDG) PET-CT my- viability study, ocardial viability assessment. Eur J Nucl Med 2. Investigating suitable substitute for new Mol Imaging (2012) 39 (Suppl 2) S3 84-S497 protocol for viability study, A. J. Nordin, W. A. Wan Ahmad, A. L. Ahmad, 3. Highlighting the potential of 18F-FDG F. F. Ahmad Saad, A. Z. F. Azman, S. Zuh- myocardial viability in identifying patients who di; Serdang/MY, Kuala Lumpur/MY,Cyberjaya/ will benefit from revascularization. Exploiting MY. Attenuation corrected PET-CT myocardial FDG PET-CT capability to perfusion using 82Rubidium allow quantifica- reduce the number of mis-diagnosed tion of coronary flow reserve with improve left hibernating and infarcted segments , ventricular function assessment - a preliminary 4. Redefining the normal value of myocardial experience. (accepted poster for European As- flow reserve in Malaysian/Asian sociation of Radiology. 2013) population , 5. Developing normal LV polar map database for Asian population to be utilized for interpreting myocardial perfusion study using 82-Rubidium 181 Research Activities and Outputs 2012-2013

Molecular Imaging

Researcher Profile: Profile :Dr Shazreen Shaharuddin Specialization : Medical Physiology Working Experience : 8 years Field of interest : Molecular Imaging

Collaborator Profile: Prof. Dr. Abdul Jalil Nordin Specialization : Interventional cardiology

Synopsis: Achievements: Molecular imaging 18f-fdg pet-ct can be used Shazreen Shaharuddin, Ahmad Zaid to detect raised metabolism of vascular plaque Fattah Azman, KatizaHaida Ali, Abdul for early recognition of high risk patient in Latif Mohamad, FathinulFikri Ahmad Saad, developing thromboembolic vascular diseases Abdul Jalil Nordin Vulnerable plaque detection: such as coronary artery disease,peripheral The role of 18-fluorine fluorodeoxyglucose arterial disease and cerebrovascular diseases in identifying high risk patients. Alexandria Medical Journal. 2013. 49(3). In press

RESEARCH REPORTS

Research Grant Research Published Manuscripts 201 Research Activities and Outputs 2012-2013

INTERNATIONALIZATION Centre For Diagnostic Nuclear Imaging Putra University Of Malaysia - A Sneak Peek

4 6 5 2

No Institution

1 University Groningen

2 Milan Bicocca University Ospedale Niguarda San Rafael Hospital

3 Ospedale Monaldi Napoli

4 International Atomic Energy Agency

5 University Brescia University Hospital Brescia

6 University Zurich Research Activities and Outputs 2012-2013 21

National And International Research Collaboration With (MOU)

No Institution Since

1 University of Innsbruck 2012

2 Mc Gills University, Canada 2012

PET-CT Case-Mix Referrals

Figure 1: Pie chart shows the case mix of 191 patients by disease categories who underwent PET-CT study at PPDN in 2012

Among the 191 case-mix referrals, the major indication for referrals are for Rb-82 cardiac perfusion (94), oncology (84), MyoPET (6), Neurology (5) and cardiology (46%) followed by infection ( 2),(Fig 1).The number of the Rb-82 cases has shown a staggering rise above the oncology which is attributable to the recruitment of patient under the approved RUGS grant scheme in 2012. 221 Research Activities and Outputs 2012-2013

Hospital Referrals

Number of Patients

Year 2010 171

Year 2011 125

Year 2012 192

Amount Of The On-Going Research Grants (2012) Type Title RM

RUGS The clinical value of multimodality imaging for detecting 04.02-12- RM108,000 occult metastatic diseases in ovarian malignancy. 1755RU

RUGS Clinical value of intravenous contrast during whole body 04-02-12- RM15,000 18F-FDG PET CT imaging in cancer patient 1748RU

RUGS Establishing the clinical role of multi-modality imaging in 04-02-12- RM30,000 diagnosis of Alzheimer’s disease - pilot study 1749RU

RUGS Optimization of 18F-FDG dose adjusted for whole-body PET 04-02-12- RM30,000 oncology examination in CDNI of UPM 1750RU

RUGS Variation in radiation dosimetry for workers in multi-modality 04-02-12- RM30,000 imaging PET CT facility 1751RU Research Activities and Outputs 2012-2013 23

Number Of Publication (2009-2012) 241 Research Activities and Outputs 2012-2013

Research Awards

Year Title Event

2012 SethuThakachySubha ,Fathinul AS Saraiza Abu Annual Scientific Meeting of the Bakar, MuhamadAzrif , Abdul JalilNordin.The College of Radiology, AMM 2012 Clinical Outcome of head and neck malignancy patients using integrated Positron Emission Oral Presentation (Silver Medal) Tomography Computed Tomography - an initial experience

2012 F.Fathinul, Zanariah H, AJ Nordin Localisation Pameran Rekacipta Penyelidikan and prediction of recurrent Phaeochromocytoma/ dan Inovasi (PRPi), Malaysia: Paraganglioma(PCC/PGL) using diagnostic 18[F] FDG-PET/CT Poster Presentation (Silver Medal)

2012 Syafinaz Amin Nordin, FaridahIdris, Malina 1st USIM international Conference Osman, RukmanAwangHamat, FadzillahGhazali, in Medicine and Health FathinulAS.Refusing vaccines, they are not the odd ‘Islamic and halal Concept in ones out Medicicne’

Poster: Silver medal

2012 The value of quantifying myocardial flow reserve 68th Korean Congress of in relation to left ventricular function on myocardial Radiology perfusion PET-CT using 82RubidiumAbdul Jalil Nordin1, Wan Azman Wan Ahmad2,FathinulFikri Travel Grant (USD 500) Ahmad Saad1, Ahmad Zaid Fattah Azman1, Abdul Latiff Mohamed3

2012 Scientific Photo Contest 68th Korean Congress of Radiology Champion Research Activities and Outputs 2012-2013 25

Professional Consultancy Service No Scientific/Peer Group Organisation Designation Year

1 British Journal of Radiology Associate 2012 (Prof Dr Abdul Jalil Nordin) Editor

2 Journal of Medical Diagnostic Method Editor 2012 Special issues in Molecular Diagnostic and Critical Medicine (Dr FathinulFikri)

3 Journal of Medical Diagnostic Method Reviewer 2012 (Dr FathinulFikri)

4 Journal of Medical Oncology (Dr Fathinul Fikri) Reviewer 2012

5 Book Chapter: In Tech Reviewer 2012 (Dr Fathinul Fikri)

6 Book Chapter: iConcept Press Reviewer 2012 (Dr FathinulFikri)

Post Graduated Students (Master in Science) No Name Internship Graduate

1 Mohd Hafizi Mahmud GS30696 2013

2 Noor Nadwa Kamaruddin GS24381 2012

3 Dr Shazreen Shaharudin GS28603 2013

4 Kamarul Amin (UiTM) 2013 261 Research Activities and Outputs 2012-2013

Manuscripts No Title Journal Status

1 Abdul JalilNordin, Noraini Ibrahim, FathinulFikri, Chapter in book). published Ahmad Zaid Fatah. The role of contrast CT Imaging Book. Enhanced CT in integrated PET/CT study (Chapter 8). Clinical application. InTech, January 2012. ISBN 978-953-307-378-1 InTech

2 FathinulFikri, AJ Nordin, E F Eddie lau.18[F] Cell Biochemistry and published FDG-PET/CT is a useful molecular marker in Biophysic. evaluating tumour aggressiveness; a revised DOI: 10.1007/s12013- understanding of an in- vivo FDGPET imaging 012-9395-5 that alludes the alteration of cancer biology. Pubmed IF 4.32 (ISI/Pubmed cited)

3 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, Eur J Nucl Med Mol accepted NA Rahim, AS FathinulFikri, AZF Azman, C Imaging (2012) 39 Rossetti. *The performance of nicotinic acid (Suppl 2) S3 84-S497 in shifting myocardial metabolism to glucose in 18F-labeled 2-deoxyglucose (FDG) PET-CT myocardial viability assessment

4 AS FathinulFikri, AKroiss , W.F.E Lau, H ActaRadiologica. published Zanariah , Z F Ahmad, C Uprimny, E (2012). in review Donnemiller, D Kendler , AJ Nordin, IJ Pubmed IF 1.85 Virgolini . Localisation and prediction of local disease control in recurrent Phaechromocytoma/ Paraganglioma(PCC/ PGL) using 18[F]FDG-PET/CT.

5 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, Eur J Nucl Med Mol published NA Rahim, AS FathinulFikri, AZF Azman, C Imaging (2012) 39 Rossetti. *The value of functional imaging in (Suppl 2) S3 84-S497 monitoring anti-tuberculosis treatment using PubmedIF 4.5 18F-FDG PET in comparison to morphological 3-dimensional CT changes.

6 Andreas Gunter Bach, Carlos Santiago European Jounal of published Restrepo, Jasmin Abbas1, María José Lorenzo Radiology. Dus,ReinhardSchöpf, FathinulFikri Ahmad PubmedIF 2.65 Saad, Eddie Lau, Jose Rubio Alvarez, Curd Behrmann,Rolf Peter Spielmann, Alexey Surov. Imaging of nonthrombotic pulmonary embolism. Research Activities and Outputs 2012-2013 27

7 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, Eur J Nucl Med Mol published NA Rahim, AS FathinulFikri, AZF Azman, Imaging (2012) 39 C Rossetti. *Extrapulmonary tuberculosis (Suppl 2) S3 84-S497 infection is an important cause of false positive FDG-avidity in PET-CT imaging studies of malignant conditions albeit has potential role in monitoring anti-tuberculosis treatment.

8 FathinulAS , AJ Nordin, R Dharmendran, Cancer imaging.(2012) published P Vikneswaran. The value of pretreatment Pubmed, Medline, PET-CT in predicting survival in patient with scopus esophageal cancer.

9 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, Eur J Nucl Med Mol published NA Rahim, AS FathinulFikri, AZF Azman, C Imaging (2012) 39 Rossetti.*Multimodality imaging PET-CT using (Suppl 2) S3 84-S497 18F-labeled 2-deoxyglucose (FDG) ensures effective treatment delivery by improving the staging of head and neck malignancy.

10 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, Eur J Nucl Med Mol published NA Rahim, AS FathinulFikri, AZF Azman, C Imaging (2012) 39 Rossetti.*Multimodality imaging PET-CT using (Suppl 2) S3 84-S497 18F-labeled 2-deoxyglucose (FDG) ensures effective treatment delivery by improving the staging of head and neck malignancy.

11 Abdul JalilNordin, Hisham AR, Fahrudin Malaysian orthopaedic published CH, Husin P, FathinulFikri Ahmad Saad, Journal. 2012. 6 Ahmad Zaid Fatah. A new clinical approach (Supp. A) 22. in detection of hip prosthesis infection using multimodality functional imaging technique 18F –fluorodeoxy glucose (FDG) PET-CT – preliminary data.

12 Ahmad Fazli, AJ Nordin, Wan Azman, Fathinul Copyrighted F AS. Database development for myocardial PET-CT using FDG. 2012. 281 Research Activities and Outputs 2012-2013

Proceeding /Poster No Title

1 SethuThakachySubha ,Fathinul ASSaraiza Abu Annual Scientific Meeting College of Bakar, MuhamadAzrif , Abdul JalilNordin.The Clinical Radiology of Malaysia (oral) Outcome of head and neck malignancy patients using integrated Positron Emission Tomography Computed Tomography - an initial experience .

2 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA EANM’12 – Annual Congress of the Rahim, AS FathinulFikri, AZF Azman, C Rossetti. European Association of Nuclear *The value of functional imaging in monitoring Medicine anti-tuberculosis treatment using 18F-FDG PET in (October 27 – 31, 2012 in Milan/ comparison to morphological 3-dimensional CT Italy). changes. (poster)

3 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA CN192 International Conference on Rahim, AS FathinulFikri, AZF Azman, C Rossetti. Radiation Protection in Medicine *Extrapulmonary tuberculosis infection is an – Setting the Scene for the Next important cause of false positive FDG-avidity in Decade 3-7 December 2012 Bonn, PET-CT imaging studies of malignant conditions Germany) (poster) albeit has potential role in monitoring anti- tuberculosis treatment.

4 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA EANM’12 – Annual Congress of the Rahim, AS FathinulFikri, AZF Azman, C Rossetti. European Association of Nuclear *Multimodality imaging PET-CT using 18F-labeled Medicine 2-deoxyglucose (FDG) ensures effective treatment (October 27 – 31, 2012 in Milan/ delivery by improving the staging of head and neck ITALY ). malignancy (poster)

5 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA EANM’12 – Annual Congress of the Rahim, AS FathinulFikri, AZF Azman, C Rossetti. European Association of Nuclear *Multimodality imaging PET-CT using 18F-labeled Medicine 2-deoxyglucose (FDG) ensures effective treatment (October 27 – 31, 2012 in Milan/ delivery by improving the staging of head and neck ITALY). (poster) malignancy

6 AJ Nordin, L Bertolazzi, G Agnese, L Deciolo, NA EANM’12 – Annual Congress of the Rahim, AS FathinulFikri, AZF Azman, C Rossetti. European Association of Nuclear *State of the art PET-CT technique;one-stop Medicine. (October 27 – 31, 2012 percutaneous PET-CT guided biopsy : a new local in Milan/ITALY). (poster) experience.

7 Abdul JalilNordin ,Noraini Abdul Rahim, Radiation Protection , IAEA, Bonn, NorhafizahMokhtaruddin, FathinulFikri, Ahmad Germany December 2012 Zaid Fattah Azman. Extrapulmonary tuberculosis infection is an important cause of false positive FDG-avidity in PET-CT imaging studies of malignant conditions albeit has potential role in monitoring anti-tuberculosis treatment. Research Activities and Outputs 2012-2013 29

8 Abdul JalilNordin1 ,FathinulFikri Ahmad Saad1, PET-CT myocardial viability Ahmad Fazli Abdul Aziz1, Ahmad Zaid Fattah assessment - update MR cardiac ; Azman1 ,Wan Himratul Azliza2, Wan Azman Cannes, France April 2012 Ahmad2 (poster) Nicotinic acid as an alternative hypolipidemic agent in shifting myocardial metabolism to glucose in 18F– labeled 2-deoxyglucose (FDG)

9 Abdul JalilNordin ,Noraini Abdul Rahim, FathinulAS. Annual Scientific Meeting College Mediastinal mass sampling at percutaneous PET- of Radiology of Malaysia. Mac 2012 CT guided biopsy : setting a new course in patient (poster) management after multiple futile biopsies .

10 Abdul JalilNordin ,Fathinul AS , Ahmad 68th Korean Congress of Fazli Abdul Aziz1, Ahmad Zaid Fattah Radiology, 2012. (poster) Azman,WanHimratulAzliza, Wan Azman Wan Ahmad.The value of quantifying myocardial flow reserve in relation to left ventricular function on myocardial perfusion PET-CT using 82Rubidium.

11 FathinulAS , AJ Nordin, R Dharmendran, P 12th Annual Teaching Course Vikneswaran . The value of pretreatment PET-CT and International cancer imaging in predicting survival in patient with esophageal Society Meeting, Oxford, UK cancer. (poster)

12 Syafinaz Amin Nordin, FaridahIdris, Malina Osman, USIM’S 1ST International Health RukmanAwangHamat, FadzillahGhazali, FathinulAS. Conference on Medicine and Health Refusing vaccines, they are not the odd ones out: a Science (poster) case report

13 Teikhin Tan, Boon Nang Lee, FathinulFikri Malaysian Endocrine Society Ahmad Saad, Zanariah Hussein. Comparison Annual Congress, Mac 2012, Kota the effectiveness of 131 I-MIBG scintifraphy, 68 Bharu. (poster) Ga-DOTATATE PET/CT and 18F-FDG PET/CT in mapping malignant phaechromocytoma and paraganglioma- Putrajaya experience, 301 Research Activities and Outputs 2012-2013

14 FathinulFikri. PET-Ct in neuroendocrine Tumour . Guest Speaker. Annual Scientific Meeting, College of Radiology Malaysia 2012, April 2012 (speaker)

15 FathinulFikri. PET-CT in Cancer Biology Mini Symposium on Biotracer (Neuroendocrine Tumour).Speaker. Discovery: from bench to bedside. UPM, Malaysia.2012 (speaker)

16 F.Fathinul, Zanariah H, AJ Nordin Localisation Pameran Rekacipta Penyelidikan and prediction of recurrent Phaeochromocytoma/ dan Inovasi Malaysia, (PRPi),UPM, Paraganglioma(PCC/PGL) using diagnostic 18[F] 19-21 Julai 2012 FDG-PET/CT. (poster)

17 Muhammad Hishar Hassan, FathinulFikri, Abdul National conference in Physic 2012 jalilNordin. Association of total activity 18F-FDG (PERFIK) 19-21st November Bukit injected with the overall Pet image quality in Tinggi, Pahang. oncology patient.

18 Mohd. Hafizi Mahmud, Muhammad Hishar Hassan, Korean Congress of Radiology, FathinulFikri, Abdul JalilNordin, Ahmad Zaidfatah . 2012. The effect of integrating contrast enhanced CT in 18F-FDG PET/CT imaging of cancer patient. Research Activities and Outputs 2012-2013 31

Published Manuscript IF : 2.6 321 Research Activities and Outputs 2012-2013 Scopus Research Activities and Outputs 2012-2013 33 341 Research Activities and Outputs 2012-2013 Research Activities and Outputs 2012-2013 35 IF : 4.2 361 Research Activities and Outputs 2012-2013 Acknowledgement

H&A Medical Supply Sdn Bhd (760352-T) Pusat Pengimejan Diagnostik Nuklear Universiti Putra Malaysia 43400 Serdang Selangor Darul Ehsan Tel : 603-8947 1644 Fax : 603-8947 2775 Web : www.ppdn.upm.edu.my