Diffuse lung infiltration in a homosexual man without AIDS
RICHARD POHIL, MD PHILIP MAPLE, MD GILBERT D ALONZO, DO
Homosexual men who present Physical examination on admission revealed the pa- with respiratory complaints and diffuse tient to be well developed and healthy appearing. The lung infiltrates on chest x-ray generally oral temperature was 100 F, and the respiratory rate have the AIDS syndrome and an ongoing was 22 breaths/min; otherwise, his vital signs were nor- opportunistic pneumonia. In the case mal. Bibasilar mid-to-end inspiratory crackles were presented, the usual diagnosis was not heard on auscultation. There was no evidence of ade- found and the patient s lung infiltrates and nopathy, abdominal organ enlargement, or skin lesions, and the oral and rectal examinations had normal find- symptoms were due to drug-induced ings. eosinophilic pneumonia. This case report Diffuse, bilateral, interstitial-alveolar infiltrates were demonstrates that not all homosexual men demonstrated on the chest roentgenogram (Fig 1). The who present with the usual clinical picture electrocardiogram was normal. Values for arterial P02, for AIDS have AIDS and that not all diffuse PCO2, and pH were 60 mm Hg, 34 mm Hg, and 7.41, lung infiltrates are infectious in etiology. respectively. The peripheral leukocyte count was 12,000/ cu mm. The differential count included 66% eosinophils; the total eosinophil count was 80,000/cu mm. A homosexual man with diffuse pulmonary in- Based on presumptive diagnosis of Pneumocystis car- filtrates, cough, and hypoxemia usually is thought inii pneumonia, the patient initially was treated with to have acquired immunodeficiency syndrome an intravenous trimethoprim and sulfamethoxazole com- (AIDS). In such cases, the pulmonary infiltrates bination. The next morning, approximately 14 hours fol- are considered to be of infectious origin; Pneumocys- lowing admission, bronchoscopy, bronchoalveolar lavage, tis carinii, 1 cytomegalovirus, 2 and nontubercular and multiple transbronchial biopsy were performed un- mycobacterial infections3 generally are suspected. der fluoroscopic guidance. The case reported here demonstrates that not Histologic examination of the biopsy specimens re- all homosexual men who present with the classic vealed only marked eosinophilic infiltration (Fig 2). Bron- clinical picture have AIDS, and that not all diffuse choalveolar lavage failed to reveal an infectious etiol- ogy. Routine and special cultures for fungus, virus, lung infiltrates are infectious in etiology. Chla- mydia, Mycoplasma, Legionella, and Mycobacterium Report of case were negative. Stool specimens, as well as a duodenal aspirate, failed to demonstrate ova or parasites. There A 25-year-old homosexual man was admitted in August was no deficiency of helper T-lymphocytes, and the T- 1984 for evaluation of a productive cough with clear spu- cell helper/suppressor ratio in the peripheral blood was tum, bilateral pleuritic chest pain, and exertional dysp- normal. nea of two weeks duration. Following the fiberoptic bronchoscopy, antibiotic ther- Several days prior to the onset of these symptoms, a apy was discontinued, and steady improvement of both sore throat, coryza, and an oral ulceration were noticed clinical and laboratory parameters occurred. Subse- by the patient. Oral cephalosporin therapy was pre- quently, a chest film reflected clearing of the lung infil- scribed, but it was discontinued after a single dose when trates (Fig 3), and arterial blood gas values had normal- urticaria developed. Next, tetracycline (500 mg, four ized. Eight days after admission, immediately prior to times a day) was prescribed and taken for approximately discharge, the peripheral total eosinophil count decreased one week. All three symptoms improved in two to three to 1,000 cells/cu mm. days, but as they resolved, cough, chest pain, and dysp- At follow-up examination four months later, the pa- nea appeared and then worsened. The patient had rein- tient s chest roentgenogram, arterial blood gas levels, stituted tetracycline therapy for approximately 48 hours and CBC (including peripheral smear) were normal. Two prior to hospital admission. years after discharge, he remained asymptomatic, and The medical history revealed that in March 1983, the serologic testing for human immunodeficiency virus was patient experienced an illness characterized by diarrhea, negative. weight loss of approximately 10 lb, and generalized mal- aise. Mild leukopenia and anemia also were present. Al- though definite diagnosis was not determined, the ill- Discussion ness resolved spontaneously. Since the recognition of AIDS in 1981, the disease