Data Sheet (Cat.No.TN1690)

Glabrene Chemical Properties

CAS No.: 60008-03-9 Formula： C20H18O4 Molecular Weight： 322.4 Appearance： N/A Storage： 0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Biological Description

Description Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely the major contributors to the notable synergistic antioxidant activity when coupled with pea protein hydrolysates (PPHs).Glabrene has -like activity, it can stimulate DNA synthesis in human endothelial cells (ECV-304; E304) and has a bi-phasic effect on proliferation of human vascular smooth muscle cells (VSMC). Glabrene and may serve as candidates for skin-lightening agents, they exert varying degrees of inhibition on -dependent biosynthesis.

Targets(IC50) Tyrosinase: None /ERR: None Estrogen/progestogen Receptor: None In vitro The inhibitory effect of licorice extract on tyrosinase activity was higher than that expected from the level of in the extract. This led us to test for other components that may contribute to this strong inhibitory activity. Results indicated that Glabrene and isoliquiritigenin (2',4',4-trihydroxychalcone) in the licorice extract can inhibit both mono- and diphenolase tyrosinase activities. The IC(50) values for Glabrene and isoliquiritigenin were 3.5 and 8.1 microM, respectively, when tyrosine was used as substrate. The effects of Glabrene and isoliquiritigenin on tyrosinase activity were dose-dependent and correlated to their ability to inhibit melanin formation in melanocytes.

Solubility Information

Solubility < 1 mg/ml refers to the product slightly soluble or insoluble

Preparing Stock Solutions 1mg 5mg 10mg 1 mM 3.102 mL 15.509 mL 31.017 mL 5 mM 0.62 mL 3.102 mL 6.203 mL 10 mM 0.31 mL 1.551 mL 3.102 mL 50 mM 0.062 mL 0.31 mL 0.62 mL Please select the appropriate solvent to prepare the stock solution, according to the solubility of the product in different solvents. The storage conditions and period of the stock solution: - 80 ℃ for 6 months; - 20 ℃ for 1 month. Please use it as soon as possible.

Page 1 of 2 www.targetmol.com A DRUG SCREENING EXPERT Reference 1. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots.J Agric Food Chem. 2003 Feb 26;51(5):1201-7.

Inhibitors · Natural Compounds · Compound Libraries This product is for Research Use Only · Not for Human or Veterinary or Therapeutic Use. Tel:781-999-4286 E-mail:[email protected] Address:36 Washington Street,Wellesley Hills,MA 02481

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