Warta Kerajaan Persekutuan 1033
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BIOT 1 in Silico Design of Integrated Downstream Processes for Non
BIOT 1 In silico design of integrated downstream processes for non-mAb biologics produced in complex expression systems Nicholas Vecchiarello2, [email protected], Chaz Goodwine3, Steven M. Cramer1. (1) Ricketts Bldg, Rensselaer Polytechnic Inst, Troy, New York, United States (2) Rensselaer Polytechnic Institute, Troy, New York, United States (3) Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, United States For biomolecules not amenable to affinity capture, determining optimal downstream processes can be a major challenge due to the broad range of experimental design space available with regard to resins, buffer pH, and salt. Previous work in our group has addressed this issue for products produced in Pichia pastoris by chromatographically characterizing process-related impurities found in spent cultivation fluids on a set of multimodal, HCIC, and ion exchange resins for a wide range of conditions using UP-RPLC. The collected data was used in concert with product retention data and a custom in silico tool to generate and rank integrated downstream processes for three non-monoclonal antibody products expressed in P. pastoris. In this work, we have chromatographically characterized the host-related impurity behavior for a CHO cell line containing a more significant HCP burden. In an effort to expedite process development, a method for assessing global orthogonal selectivity for different process-related impurities between resin pairs was employed in order to prune the number of resins required for screening. This strategy was then applied to the purification of a product with a significant variant challenge. To further reduce the number of resins to screen for product retention, sequence understanding and biophysical properties were utilized to focus on regions that would likely remove host- related impurities and offer variant selectivity. -
Warta Kerajaan S E R I P a D U K a B a G I N D a DITERBITKAN DENGAN KUASA
M A L A Y S I A Warta Kerajaan S E R I P A D U K A B A G I N D A DITERBITKAN DENGAN KUASA HIS MAJESTY’S GOVERNMENT GAZETTE PUBLISHED BY AUTHORITY Jil. 60 TAMBAHAN No. 3 11hb Februari 2016 TMA No. 10 No. TMA 19. AKTA CAP DAGANGAN 1976 (Akta 175) PENGIKLANAN PERMOHONAN UNTUK MENDAFTARKAN CAP DAGANGAN Menurut seksyen 27 Akta Cap Dagangan 1976, permohonan-permohonan untuk mendaftarkan cap dagangan yang berikut telah disetuju terima dan adalah dengan ini diiklankan. Jika sesuatu permohonan untuk mendaftarkan disetuju terima dengan tertakluk kepada apa-apa syarat, pindaan, ubahsuaian atau batasan, syarat, pindaan, ubahsuaian atau batasan tersebut hendaklah dinyatakan dalam iklan. Jika sesuatu permohonan untuk mendaftarkan di bawah perenggan 10(1)(e) Akta diiklankan sebelum penyetujuterimaan menurut subseksyen 27(2) Akta itu, perkataan-perkataan “Permohonan di bawah perenggan 10(1)(e) yang diiklankan sebelum penyetujuterimaan menurut subseksyen 27(2)” hendaklah dinyatakan dalam iklan itu. Jika keizinan bertulis kepada pendaftaran yang dicadangkan daripada tuanpunya berdaftar cap dagangan yang lain atau daripada pemohon yang lain telah diserahkan, perkataan-perkataan “Dengan Keizinan” hendaklah dinyatakan dalam iklan, menurut peraturan 33(3). WARTA KERAJAAN PERSEKUTUAN WARTA KERAJAAN PERSEKUTUAN 2300 [11hb Feb. 2016 11hb Feb. 2016 PB Notis bangkangan terhadap sesuatu permohonan untuk mendaftarkan suatu cap dagangan boleh diserahkan, melainkan jika dilanjutkan atas budi bicara Pendaftar, dalam tempoh dua bulan dari tarikh Warta ini, menggunakan Borang CD 7 berserta fi yang ditetapkan. TRADE MARKS ACT 1976 (Act 175) ADVERTISEMENT OF APPLICATION FOR REGISTRATION OF TRADE MARKS Pursuant to section 27 of the Trade Marks Act 1976, the following applications for registration of trade marks have been accepted and are hereby advertised. -
Final Report
Final report Project code: A.BIM.0040 Prepared by: Dr Dianne Glenn Corelli Consulting Date published: January 2015 PUBLISHED BY Meat & Livestock Australia Locked Bag 991 NORTH SYDNEY NSW 2059 Published by Blood-based proteins: A market review Meat & Livestock Australia acknowledges the matching funds provided by the Australian Government to support the research and development detailed in this publication. This publication is published by Meat & Livestock Australia Limited ABN 39 081 678 364 (MLA). Care is taken to ensure the accuracy of information in the publication. However MLA cannot accept responsibility for the accuracy or completeness of the information or opinions contained in the publication. You should make your own enquiries before making decisions concerning your interests. Reproduction in whole or in part of this publication is prohibited without the prior written consent of MLA. A.BIM.0040 Blood-based proteins: a market review Contents Section Page 1 Background ..........................................................4 2 Executive Summary .............................................5 2.1 Key findings ....................................................................................5 2.2 Next Steps .......................................................................................8 3 Opportunity ........................................................11 3.1 Food industry ............................................................................... 11 3.2 Animal Feed industry .................................................................. -
Summer06 Inroadspressagain802.Qxp 8/15/2006 2:40 PM Page 1 Inroads Bridgestone Firestone North American Tire, LLC O Summer 2006
summer06 inroadsPressAgain802.qxp 8/15/2006 2:40 PM Page 1 inRoads Bridgestone Firestone North American Tire, LLC O Summer 2006 Executive Be a Community Leader in Safety! page ................................2 Feature Edge There is one thing that all of available to drivers aged 15-21; visit your customers are www.DriversEdge.org to see when and concerned about and that is safety. Drivers where the program is offered. Dealers page........................2,3,8,9 hold their breath as they pass an accident, cross their fingers as their family member pulls out of the driveway, and sigh in relief when missing a near fender bender. You can also reach out to your home Truck & Bus page ............................4,5 Everyone can benefit from learning community by conducting your own Car techniques to be safer on the road. Care Academy, an educational program on As a dealer, you are in a unique position proper car care. BFNT will send interested Consumer page ..........................4,11 to provide drivers with the tools, literally dealers a complete program kit which and figuratively, to keep them safe. We includes all the materials needed for a encourage you to talk to your customers successful Car Care Academy. This fantastic about programs and resources available to grassroots tool provides your customers Motorsport page ................................5 them as a means to continually sharpen with a hands-on experience and really their driving skills. shows your community you care about Bridgestone Firestone North American safety. Reach out to your community Awards page ............................6,7 Tire, LLC (BFNT) has worked with legendary members and provide priceless tips and race car driver Mario Andretti to develop a instruction at no cost to the participants.