@ I @,;;J •:4 i

Whole-Body Thallium 1443

Radioimrnune Imaging of Bone Marrow in Breast Cancer Patients . 1450

Brain Perfusion SPECT Using an Annular Single Crystal Camera . 1456

Quantitative Hepatobi1iar@ Scintigraphy 1462

Receptor Scintigraphv with Radioiodinated Somatostatin 1501

A Full Table of Contents Begins on Page 4A, Annotations on Pages 7A-8A

The Official Publication of @ The Society of , Inc. -@ In This Month's Issue of [‘2@I]MIBGin a Phase I toxicity Exercise Whole-Body Thallium study. Of the normal tissues, platelet Scintigraphy in the Diagnosis and leukocyte formationwas the and Evaluation of Occlusive most vulnerableto the radiation. Arterial Disease in the Legs One patientdied of progressive Whole-body thallium scans were JNM neuroblastoma, but the other two taken immediately and at 4 hours exhibitedonly modest reductionsin circulatinglevels of plateletsand following treadmillexercise in 36 patients suspected of having SO healthyindividualsand in 17pa dysfunctionwere studiedprospec leukocytes following whole-body tients with occlusive arterial disease. tively using SO manometryand radiation treatment Page147) Using the criteria of uptake and QHBS, there was agreement in 7 symmetry, suspected occlusive cases (4 normal, 3 abnormal). No Serum Osteocalcin Measure arterial disease was detected with significantcorrelationexisted ments in Prostate Carcinoma high sensitivity and specificity. between the quantitative parameters Patients with Skeletal Deposits Page 1443 of the two tests Page1462 Shown by Bone Scmntigram: Comparison with Serum Radloimmune Imaging of Bone Editorial: Quantitative PSA/PAP Measurements Marrow in Patients with Hepatobiliary Scintigraphy Serumosteocalcin, prostate-specific Suspected Bone Metastases Page 1468 antigens (PSA) and/or prostate acid from Primary Breast Cancer phosphatase (PAP) were measured Datafrom 32 patientswith Scintigraphic Assessment of by radioimmunoassayand im suspectedmetastasesfromprimary Indium-Ill-Labeled munoradiometricassay in 18men breast cancer supports the concept Granulocyte Splenic POoling: A positive for bone metastases. Six that in the timecourseof boneinva New Approach to Inflam showed elevation of osteocalcin, all sion, bone marrowis first invaded. matory Bowel Disease Activity of whom had extensive bone Patients with risks of bone metastases.All 18menhad high metastases due to stage of disease or Scans were acquired in 96 patients serumPSAand/orPAPlevels. clinical suspicion of bone metastases who were divided into six groups: Page 1486 and who presentwith normalor normalvolunteers,inflammatory benign bone scans may benefit from rheumatism, abcesses, ulcerative Intravenous Erythromycin a bone marrow scan Page1450 collitis, colonic Crohn's disease, and ileal Crohn's disease. There was a Dramatically Accelerates significant correlation between fecal Gastric Emptying in Brain Perfusion SPECf Using excretionof “Inanda fail in Gastroparesis Diabeticorum and Normals and Abolishes the an Annular Single Crystal splenic activity (FSA) in patients Emptying Discrimination Camera: Initial Clinical with inflammatorybowel disease Experience andbetween variationsin FSA and Between Solids and Liquids The annularsingle-crystalbrain in fecalexcretionof 11‘In. . .Page1470 Gastric emptying was determined in camera (ASPECT) system was patientsusing @“Tc-sulfurcolloid evaluated clinically by the use of a McCune-Albright Syndrome: and “In-DTPAin water.Following Hoffmanbrainphantomand seven The Patterns of Scintigraphic a baseline study,each patient subjects, of whom two were normal Abnormalities received a 15-mini.v. perfusionof controls, three had previous cerebral Erythromycin,which dramatically infarction, and two had dementia. The scintigraphicdistributionof accelerated gastric emptying of both Page 1456 fibrousdysplasiawas examinedin solids and liquids. After chronic 22 patientswith McCune-Albright oral administration,solidand liquid syndrome. The most frequently emptying remained significantly Sincalide-Augmented Quan affectedareaswerethe baseof the accelerated Page 1490 titative Hepatobiliary Scm skull (82%), legs (64%), femora tigraphy (QHBS): Definition of (59%), mandible (50%), and facial Normal Parameters and bones (45%) Page1474 A Model of Gastric Emptying Preliminary Relationship in Cats Shows Solid Emptying Between QHBS and Sphincter is Prompted by MK-329: A of Oddi (SO) Manometry in Iodine-125-MIBG to Treat CCK Anatgonist Patients Suspected of Having Neuroblastoma: Preliminary Report Gastric emptying of a labeled liquid SO Dysfunction and solid meal was measuredbefore NormalQHBSparameterswere Three childrenwith StageIII and afteradministrationof an oral determined in 29 patients. When 10 neuroblastoma were treated with CCK antagonist Page 1494

Annotations 7A Receptor Scintigraphy with a Human colon adenocarcinoma patientwith chronic myelogenous Radioiodinated Somatostatin spheriodswereusedto evaluatethe leukemia Page 1552 Analogue: Radiolabeling, efficacy of alpha emitter-labeled Purification, Biologic Activity, in a three-dimensional Three-Phase Radionudide and In Vivo Application in model. Initial kinetic studies Bone Imaging in Stress Injury Animals revealed that a large number of of the Anterior Iliac Crest binding sites/cell and high affinity Invivoapplicationof this slowed penetration. Therapy was 1\woadolescents with stress-related radioligandfor the detectionof 5514 very effective in killing single cells avulsioninjuryof the anterioriliac receptor-bearing tumors was in but ineffective in spheroids. crest apophysis are presented. vestigatedby scintigraphy.In ratsin Page 1527 Increased tracer concentration in the jected intravenously, ‘231-Tyr-3- anterioriliac crest area is presenton octreotide cleared rapidly from the blood-pool and delayed images. circulation. While limiting the Comparison of the Distribution Page 1554 amount of available tracer, the rapid of Bromine-77-BromovinylSte clearance benefited the tumor imag roidal and Triphenylethylene Peripheral Arteriovenous ing Page 1501 Estrogens in the Immature Rat Malformations: Diagnosis and Localization by The highest concentrationsin the Intraarterial Injection of estrogen target tissues and the Technetium-99m-MAA Metabolism of Indium-ifi highest target tissue-to-blood ratios Labeled Murine Monoclonal were foundwith [7@Br]bromovinyl A singlepatientwithlowerlimbAV in Tumor and methoxyestradiol,but with high malformation was subjected to Normal Thsue of the Athymic nonspecific uptake as well. The radionudide with Mouse triphenylethyleneestrogen showed @Tc-labeledMAA. The authors Athymic mice bearing colonic comparablespecific uptakein suggest that this method has utility tumors were injected with “In estrogen target tissues at 2 1w,but both for the diagnosis and labeled murineMAbs. Liver, better apparent retention at later quantitationof AV shuntingand for kidney,and tumorwere extracted time points Page 1534 localizing the shuntingsite. and the supernatants were analyzed. Page 1557 The activity in normaltissue was ClinICal Pathologic associated with native MAt, and Conferences: MUItIfOCa1 Scatter and Attenuation with several metabolites that ap Skeletal Uptake of Labeled Correction in SPECT Using pearedtobe “In-SCN-Bz-DTPA Leukocytes: Infection Versus Density Maps and Monte Carlo boundto peptide fragments. Tumor Metastasis Simulated Scatter Functions Page 1510 Page 1543 A reconstructedemissionmapis Indium-ifi-Labeled LeUkOcyte used as an estimateof the source Immunoscintigraphy of distribution to calculate the scatter Human Tumors Transplanted Uptake in Neoplasm: Phagocytosis by Thmor Cells? contribution. That contribution is in Nude Mice with Radio then subtractedfrom the original labeled Anti-ms p21 With the presumption of myositis projectionpriorto attenuation Monoclonal Antibodies ossificans, which may containmar correction. The attenuationcorrec Clear images of cancers were row elements, @Tc-sulfurcolloid tion methoduses density maps for obtained seven days after injection imaging was performed. Leuokocyte the attenuationcorrectionof of the antibody.No localization of and sulfur colloid images were vir projection data Page1560 labeled control antibodywas tually identical. Subsequent excision observed. The ratio of tissue/blood of the mass revealed a malignant Kit Preparation of Thchnetium radioactivityand the %ID/gin the fibroushistiocytomawith associated 99m-Mercaptoacetyltriglycine: tumor were significantly higher than metaplastic bone formation. Analysis, Biodistribution and in the other organsby Day & The Page 1548 Comparison with Technetium specific localization index was also 99m-IYrPA in Patients with higher in the tumorthan in other Splenic Accumulation of Impaired Renal Function tissues Page1520 Technetium-99m-Methylene Diphosphonate in Chronic A @“Tc-MAG3kitis likelytobeof Myelogenous Leukemia valuein renaltransplantassessment and in cases of significantrenal Iodine-US NRLU-1OKinetic Intense splemc activity was inciden impairment. Such a kit does not Studies and Bismuth-212- tally observed on a bone scan appearto offer significantadvan NRLU-10 Therapy of LS174T performed for the evaluation of tages over @mTc@DTPAin routine Multicell Spheroids cellulitis versus osteomyelitis in a renal imaging Page 1568

The Journal of Nuclear Medicine •Vol. 31 •No. 9 •September 1990