Inherited Disease Screen Residual Risks

Gene Ethnicity Residual Risk Gene Ethnicity Residual Risk ABCA4 General 1 in 64 Japanese 1 in 23236 ATXN1 ABCC9 General 1 in 2170 General 1 in 52631 ABCD1 General 1 in 67197 ATXN2 General 1 in 52631 ACADVL General 1 in 1721 ATXN7 General 1 in 52631 ACTA2 General 1 in 1999981 General 1 in 1916 BAG3 ACTC1 General 1 in 4981 Cuba 1 in 2631 ACTN2 General 1 in 4981 Ashkenazi Jewish 1 in 1601 ADA General 1 in 2788 BCKDHA Mennonite 1 in 181 AIPL1 General 1 in 1534 Other or Mixed Ethnicity 1 in 4281 Iranian Jewish 1 in 572 Ashkenazi Jewish 1 in 1245 BCKDHB Finnish 1 in 1129 Other or Mixed Ethnicity 1 in 2378 Sardinian 1 in 843 BEST1 Northern Sweden 1 in 9999 AIRE Other or Mixed Ethnicity 1 in 7129 BMPR1A General 1 in 44442 Norwegian 1 in 2015 BTD Other or Mixed Ethnicity 1 in 1701 Slovenian 1 in 1472 BTK General 1 in 592851 Polish 1 in 2558 CA4 General 1 in 58317 AKAP9 General 1 in 22719 General 1 in 1999981 CACNA1C Mennonite Canadian 1 in 481 Denmark 1 in 133999 Caucasian 1 in 3861 CACNB2 General 1 in 39981 ALPL Japanese 1 in 3861 General 1 in 7129 CALR3 Other or Mixed Ethnicity 1 in 3861 Japanese 1 in 36681 French 1 in 5481 CAPN3 Caucasian 1 in 3181 Caucasian 1 in 5601 CASQ2 General 1 in 981 British Columbia 1 in 5601 General 1 in 1181 AMT Finland 1 in 5221 Other or Mixed Ethnicity 1 in 3181 Northern Finland 1 in 2441 Italy 1 in 3181 ANK2 General 1 in 49981 Southern Italy 1 in 2041 APC General 1 in 57076 CAV3 Mexico 1 in 201 APP General 1 in 188671 Lithuania 1 in 3481 APTX Portugal 1 in 2461 Croatia 1 in 2641 Caucasian 1 in 1581 Poland 1 in 2461 Swiss 1 in 2001 Amish 1 in 81 ARL6 Kuwait 1 in 581 General 1 in 1236 CCDC39 Newfoundland 1 in 661 South Asia 1 in 459 Caucasian 1 in 991 CCDC40 General 1 in 2626 Japanese 1 in 991 CDH23 General 1 in 574 Other or Mixed Ethnicity 1 in 991 General 1 in 414 CEP290 Polish 1 in 771 South Asia 1 in 984 ARSA Habbenite Jews 1 in 41 General 1 in 342 Israeli Arabs 1 in 441 CERKL European 1 in 242 Eskimoes 1 in 241 Denmark 1 in 201 Navajo Nation 1 in 391 Ashkenazi Jewish 1 in 312 Saudi Arabian 1 in 1311 Caucasian 1 in 267 ASL Other or Mixed Ethnicity 1 in 1311 African American 1 in 667 ASPA Ashkenazi Jewish 1 in 217 CFTR Asian American 1 in 1301 General 1 in 222201 Denmark 1 in 367 ATL1 Other or Mixed Ethnicity 1 in 1684 East Asia 1 in 1745 North African Jewish 1 in 762 India 1 in 1145 Amish 1 in 762 CHAT General 1 in 3981 ATM Costa Rican 1 in 762 CHD7 General 1 in 20730 Other or Mixed Ethnicity 1 in 762 CHEK2 General 1 in 592 ATP2A2 Scotland 1 in 428558 CHM General 1 in 166661 General 1 in 208330 CHRNA1 General 1 in 2231 ATP7A England 1 in 514272 CHRNB1 General 1 in 1487 Denmark 1 in 1428558 CHRND General 1 in 2624 General 1 in 1272 General 1 in 1241 CHRNE Other or Mixed Ethnicity 1 in 1272 European Roma 1 in 481 ATP7B Korean 1 in 1243 General 1 in 2221 CLCN1 Sardinian 1 in 701 Nothern Scandanavia 1 in 981

Form No.: QAF-IDRR-01 Page 1 of 5 Approved Date: 29/07/20 Inherited Disease Screen Residual Risks

Gene Ethnicity Residual Risk Gene Ethnicity Residual Risk CNGB1 General 1 in 5901 European 1 in 754142 COL11A1 General 1 in 468738 EXT1 Guam 1 in 748 COL11A2 General * General 1 in 377071 COL1A1 General * EYA1 General 1 in 384612 COL1A2 General 1 in 83317 EYS General 1 in 117 COL2A1 General 1 in 166641 F8 General 1 in 3225 COL3A1 General 1 in 624988 F9 General 1 in 124988 COL4A1 Unknown Unknown North America 1 in 572 COL4A5 Other or Mixed Ethnicity 1 in 83331 Israel 1 in 294 FANCA COL5A1 General 1 in 512801 South Africa 1 in 176 COL5A2 General 1 in 1785701 Spanish Gypsy 1 in 154 COL7A1 Other or Mixed Ethnicity 1 in 3355 North America 1 in 8076 COL9A1 General 1 in 6172 FANCC Israel 1 in 4144 CRB1 General 1 in 2216 Ashkenazi Jewish 1 in 557 CRX General * North America 1 in 20109 FANCF Rudari 1 in 14 Israel 1 in 10332 CTDP1 Roma/Gypsy 1 in 71 North America 1 in 12061 Brittany France 1 in 164 FANCG Israel 1 in 6194 CTNS General 1 in 321 Sub-Saharan Africans 1 in 661 Northern European 1 in 741 FBN1 General 1 in 31244 CYP27A1 Moroccan Jewish 1 in 27 FBXO7 General 1 in 6081 General 1 in 2921 FGFR1 General 1 in 599981 DBT General 1 in 980 FGFR3 General 1 in 39981 DCX General 1 in 47222 English 1 in 991 DES Unknown Unknown Jordan 1 in 581 FMO3 European 1 in 589 Ecuador 1 in 251 Ashkenazi Jews 1 in 467 NewGuinea 1 in 81 Hispanis 1 in 1845 FOXL2 Unknown Unknown DHCR7 African American 1 in 1521 FRG1 Unknown Unknown Northwestern Europe 1 in 1366 FRMD7 General 1 in 2777 General 1 in 747 FSCN2 General 1 in 23317 DKC1 General 1 in 9981 FXN General 1 in 61 DLD Ashkenazi Jewish 1 in 846 General 1 in 597 England 1 in 10852 Hispanic 1 in 451 GAA DMD Norway 1 in 2303 African American 1 in 267 Canada 1 in 2764 Eastern Asian 1 in 505 General 1 in 914 General 1 in 2866 DNAH11 GALT South Asia 1 in 340 African American 1 in 931 General 1 in 1055 GATA4 Unknown Unknown DNAH5 South Asia 1 in 391 General 1 in 1327 DNAH9 Unknown Unknown GBA Ashkenazi Jewish 1 in 107 General 1 in 3981 African American 1 in 225 DNAI1 South Asia 1 in 1481 General 1 in 2271 GBE1 General 1 in 8921 Ashkenazi Jewish 1 in 195 DNAI2 South Asia 1 in 3341 Caucasian 1 in 2675 DNM2 Unknown Unknown British Columbia 1 in 2675 GCSH DOK7 General 1 in 1267 Finland 1 in 790 General 1 in 263153 Northern Finland 1 in 1164 DSC2 Italy 1 in 32890 GDF5 Unknown Unknown General 1 in 22618 General 1 in 837 DSG2 Italy 1 in 2824 Northwestern Europe 1 in 645 General 1 in 17087 Ashkenazi Jewish 1 in 401 DSP Italy 1 in 2134 Hispanic 1 in 1981 General 1 in 591 GJB2 African American 1 in 487 DYSF Libyan Jews 1 in 171 South Asia 1 in 2941 ELN General 1 in 79997 Eastern Asia 1 in 641 EMD General 1 in 999981 Southern Europe 1 in 645 ENG General 1 in 56494 Middle Eastern 1 in 1641

Form No.: QAF-IDRR-01 Page 2 of 5 Approved Date: 29/07/20 Inherited Disease Screen Residual Risks

Gene Ethnicity Residual Risk Gene Ethnicity Residual Risk GJB3 Unknown Unknown KCNJ2 General 1 in 2857141 GJB6 Unknown Unknown Norway 1 in 1808 General 1 in 249991 KCNQ1 Sweden 1 in 1808 GLA Italy 1 in 15491 General 1 in 3201 Austria 1 in 19291 KCNQ4 General 1 in 8317 Caucasian 1 in 686 KIAA0196 General 1 in 27781 British Columbia 1 in 686 KLHL7 General 1 in 3499981 GLDC Finland 1 in 643 KRAS Japan 1 in 8099991 Northern Finland 1 in 296 KRT14 General 1 in 476953 General 1 in 6989 KRT5 General 1 in 1351367 GNE Iranian Jews 1 in 32 L1CAM General 1 in 214272 General 1 in 1428 LAMB3 General 1 in 11143 Portugal 1 in 1591 LAMP2 Unknown Unknown Japan 1 in 2273 LDB3 Unknown Unknown GNPTAB Netherlands 1 in 3591 LMNA General 1 in 9981 Republic of Ireland 1 in 4646 LRAT General 1 in 1821 Northern Ireland 1 in 128 LRRK2 General 1 in 1238 Quebec 1 in 346 MAPT General 1 in 333301 GPC3 Unknown Unknown MC1R Unknown Unknown GPD1L General 1 in 28558 MECP2 General 1 in 30354 GPR143 General 1 in 33783 MED12 Unknown Unknown GUCY2D General 1 in 1415 MEN1 General 1 in 24388 General 1 in 578 MERTK General 1 in 2204 Asian 1 in 20 MFN2 General 1 in 49981 HBA2 Medierranean 1 in 31 MLH1 General 1 in 5861 African American 1 in 31 US & Canada 1 in 2821 MMAA General 1 in 1373 Japan 1 in 2231 Hispanic 1 in 2541 US & Canada 1 in 5815 MMAB African American 1 in 181 Japan 1 in 4601 HBB South Asia 1 in 481 General 1 in 2721 MMACHC Eastern Asia 1 in 981 Hispanic 1 in 2141 Southern Europe 1 in 981 MPZ General 1 in 49981 Middle East 1 in 581 MSH2 General 1 in 3926 HCN4 General 1 in 9996 MTM1 General 1 in 48076 General 1 in 2579 US & Canada 1 in 911 HEXA MUT Ashkenazi Jewish 1 in 441 Japan 1 in 716 General 1 in 33 MYBPC3 General 1 in 8317 African American 1 in 231 MYH11 General 1 in 399997 HFE Hispanic 1 in 76 MYH6 General 1 in 1186 Asian 1 in 203 MYH7 General 1 in 7129 HIBCH General 1 in 2773 MYL2 General 1 in 9981 General 1 in 1883245 MYL3 General 1 in 9981 HMBS Sweden 1 in 470801 MYLK General 1 in 1999981 HR Unknown Unknown MYO7A General 1 in 321 IDS General 1 in 217387 MYOZ2 General 1 in 7129 IDUA General 1 in 786 NF1 General 1 in 6248 General 1 in 3105 NF2 General 1 in 199997 IKBKAP Ashkenazi Jewish 1 in 334 NIPBL General 1 in 4159 IL2RG General 1 in 357129 NKX2-5 General 1 in 1981 IMPDH1 General 1 in 15201 General 1 in 12116 ITGB4 General 1 in 45446 NPC1 Western Europe 1 in 743 JAG1 General 1 in 187217 France 1 in 662 General 1 in 333327 General 1 in 1575481 JUP Italy 1 in 41661 NPC2 Western Europe 1 in 96981 Norway 1 in 14121 France 1 in 86481 KCNE1 Sweden 1 in 14121 NR2E3 General 1 in 3499981 General 1 in 24981 NRAS General 1 in 19981 KCNE2 General 1 in 4999981 NSD1 General 1 in 17948 KCNE3 General 1 in 39981 NSD1 Japanese 1 in 15053 KCNH2 General 1 in 22212

Form No.: QAF-IDRR-01 Page 3 of 5 Approved Date: 29/07/20 Inherited Disease Screen Residual Risks

Gene Ethnicity Residual Risk Gene Ethnicity Residual Risk General 1 in 108 RAG1 General 1 in 1512 OCA2 Sub-Saharan Africa 1 in 23 RAG2 General 1 in 2721 African American 1 in 54 RAI1 General 1 in 15789 OCRL General 1 in 2272719 RAPSN General 1 in 496 General 1 in 15216 RB1 General 1 in 32607 Italy 1 in 76085 RDH12 General 1 in 4137 OTC Finland 1 in 67390 RET General 1 in 291659 Australia 1 in 83694 RHO General 1 in 9443 France 1 in 50 ROR2 Unknown Unknown Quebec 1 in 50 RP9 General 1 in 648145 PABPN1 Bukhara Jews 1 in 600 RPE65 General 1 in 4541 Japan 1 in 50 RPGR General 1 in 92681 PAFAH1B1 General 1 in 32467 RPGRIP1 General 1 in 6784 General 1 in 1757 RPL11 General * PAH Southern Europe 1 in 619 RPL35A General 1 in 5357142 PAX3 General 1 in 133327 RPS10 General * PAX6 General 1 in 79999 RPS19 General 1 in 3999991 PCDH15 General 1 in 1586 RPS24 General * General 1 in 1022 RPS26 General 1 in 5172411 PEX1 Japan 1 in 3243 RPS6KA3 General 1 in 79997 General 1 in 4034 RPS7 General * PEX10 Japan 1 in 4034 RS1 General 1 in 15619 General 1 in 18241 General 1 in 8921 PEX13 RSPH4A Japan 1 in 18241 South Asia 1 in 3341 General 1 in 2873 General 1 in 12621 PEX14 RSPH9 Japan 1 in 2873 South Asia 1 in 4741 General 1 in 28841 General 1 in 22053 PEX19 RYR1 Japan 1 in 28841 Japan 1 in 11759 General 1 in 10901 RYR2 General 1 in 259726 PEX26 Japan 1 in 10901 SALL4 Unknown Unknown General 1 in 22251 SCN1B Unknown Unknown PEX3 Japan 1 in 22251 General 1 in 33317 General 1 in 15801 SCN3B Southeast Asia 1 in 33317 PEX5 Japan 1 in 15801 Japan 1 in 2762 PINK1 Unknown Unknown SCN4B General 1 in 39981 PKD1 General 1 in 2785 General 1 in 19991 PKD2 General 1 in 60601 SCN5A Southeast Asia 1 in 19991 PKHD1 General 1 in 216 Japan 1 in 1657 General 1 in 4355 SCN9A General 1 in 65789 PKP2 Italy 1 in 542 SEMA4A Pakistan 1 in 1499981 PLEC General 1 in 5681 General 1 in 106 PLN General 1 in 453 Ashkenazi Jewish 1 in 151 PLOD1 General 1 in 393 Hispanic 1 in 83 General 1 in 1401 SERPINA1 African American 1 in 364 PMM2 Danish 1 in 1181 Eastern Asia 1 in 4491 PMP22 General 1 in 2941 Southern Europe 1 in 122 POLG General 1 in 491 Northwestern Europe 1 in 105 PPT1 General 1 in 843 General 1 in 217387 PRCD General 1 in 13221 America 1 in 217387 PRKAG2 General 1 in 3689 SERPING1 Denmark 1 in 308348 PROM1 General 1 in 8263 Spain 1 in 398879 PRPF31 General 1 in 349999 Norway 1 in 287931 PRPF8 General 1 in 3499981 SGCD General 1 in 2981 PRPH2 General 1 in 2799981 SH3BP2 Unknown Unknown PSEN1 General 1 in 28884 SIX1 General * PSEN2 General 1 in 970861 SIX5 General * PTCH1 General 1 in 34501 PTPN11 General 1 in 14272 RAF1 General 1 in 16651

Form No.: QAF-IDRR-01 Page 4 of 5 Approved Date: 29/07/20 Inherited Disease Screen Residual Risks

Gene Ethnicity Residual Risk Gene Ethnicity Residual Risk Caucasian 1 in 2496 Norweigan 1 in 776 China 1 in 321 Japanese 1 in 776 TXNDC3 SLC25A13 Taiwan 1 in 236 North Holland 1 in 113 Korea 1 in 246 Pakistani 1 in 288 Japan 1 in 321 TYR General 1 in 583 SLC25A4 Unknown Unknown USH1C General 1 in 762 General 1 in 2443 USH2A General 1 in 269 SLC26A4 Eastern Asia 1 in 264 VCL General 1 in 4151 SMAD3 Unknown Unknown VHL General 1 in 109088 SMAD4 General 1 in 2272719 WAS General 1 in 1249991 Males 1 in 10120 Japan 1 in 1186 SNCA WRN Females 1 in 19424 Sardinia 1 in 851 SNRNP200 General 1 in 2999981 WT1 General 1 in 199991 SNTA1 General 1 in 4999981 * Residual Risk is extremely low and cannot be accurately SOD1 General 1 in 781238 determined SOS1 General 1 in 69921 SOX9 General 1 in 266661 SPATA7 General 1 in 643 General 1 in 534 SPG7 UK 1 in 201 STARD3 Unknown Unknown General 1 in 7142844 TAF1 Phillipines 1 in 1311 Philipines (Panay Islands) 1 in 513 General 1 in 749996 TAZ England 1 in 349996 France 1 in 1499996 TBX5 General 1 in 285712 TCOF1 General 1 in 97743 TGFBR1 Unknown Unknown TGFBR2 Unknown Unknown General 1 in 1428558 TMEM43 Italy 1 in 178558 TNNC1 General 1 in 3558 TNNI3 General 1 in 4981 General 1 in 1851 TNNT1 Old Amish 1 in 167 TNNT2 General 1 in 9981 TNXB General 1 in 171 TOPORS General 1 in 2916651 General 1 in 38454 TP53 Brazilian 1 in 2557 TPM1 General 1 in 4981 General 1 in 24786 TSC1 European 1 in 48562 General 1 in 15282 TSC2 European 1 in 29942 General 1 in 3327 French (Alsace) 1 in 4467 TTPA Norwegian 1 in 4294 Italian 1 in 6227 African American 1 in 647 Portugese 1 in 10741 Swedish 1 in 1314 TTR West African 1 in 381 Caucasian 1 in 4526 Hispanic * TULP1 General 1 in 1801 TWIST1 General 1 in 35713

Form No.: QAF-IDRR-01 Page 5 of 5 Approved Date: 29/07/20