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Gaseous “Nanoprobes” for Detecting Gas-Trapping Environments in Macroscopic Films of Vapor-Deposited Amorphous Ice DOI: 10.1063/1.5113505
The University of Manchester Research Gaseous “nanoprobes” for detecting gas-trapping environments in macroscopic films of vapor-deposited amorphous ice DOI: 10.1063/1.5113505 Document Version Submitted manuscript Link to publication record in Manchester Research Explorer Citation for published version (APA): Talewar, S. K., Halukeerthi, S. O., Riedlaicher, R., Shephard, J., Clout, A., Rosu-Finsen, A., Williams, G. R., Langhoff, A., Johannsmann, D., & Salzmann, C. G. (2019). Gaseous “nanoprobes” for detecting gas-trapping environments in macroscopic films of vapor-deposited amorphous ice. The Journal of chemical physics, 151(13). https://doi.org/10.1063/1.5113505 Published in: The Journal of chemical physics Citing this paper Please note that where the full-text provided on Manchester Research Explorer is the Author Accepted Manuscript or Proof version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version. General rights Copyright and moral rights for the publications made accessible in the Research Explorer are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Takedown policy If you believe that this document breaches copyright please refer to the University of Manchester’s Takedown Procedures [http://man.ac.uk/04Y6Bo] or contact [email protected] providing relevant details, so we can investigate your claim. Download date:30. Sep. 2021 Gaseous ‘nanoprobes’ for detecting gas-trapping environments in macroscopic films of vapor-deposited amorphous ice Sukhpreet K. Talewar,a Siriney O. -
Acoustic Immunosensing of Exosomes Using a Quartz Crystal Microbalance with Dissipation Monitoring
Acoustic immunosensing of exosomes using a quartz crystal microbalance with dissipation monitoring. Jugal Suthar,y,z Edward S. Parsons,{ Bart W. Hoogenboom,{,x Gareth R. Williams,y and Stefan Guldin∗,z yUCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX, United Kingdom zDepartment of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, United Kingdom {London Centre for Nanotechnology, 17-19 Gordon Street, London, WC1H 0AH xDepartment of Physics and Astronomy, University College London, Gower Street, London, WC1E 6BT E-mail: [email protected] Abstract Exosomes are endocytic lipid-membrane bound bodies with potential to be used as biomarkers in cancer and neurodegenerative disease. The limitations and scarcity of current exosome characterisation approaches has led to a growing demand for trans- lational techniques, capable of determining their molecular composition and physical properties in physiological fluids. Here, we investigate label-free immunosensing, using a quartz crystal microbalance with dissipation (QCM-D), to detect exosomes by ex- ploiting their surface protein profile. Exosomes expressing the transmembrane protein 1 CD63 were isolated by size-exclusion chromatography from cell culture media. QCM-D sensors functionalised with anti-CD63 antibodies formed a direct immunoassay towards CD63-positive exosomes, exhibiting a limit-of-detection of 1.7x108 and 1.1x108 exosome sized particles (ESPs)/ ml for frequency and dissipation response respectively, i.e., clin- ically relevant concentrations. Our proof-of-concept findings support the adoption of dual-mode acoustic analysis of exosomes, leveraging both frequency and dissipation monitoring for use in diagnostic assays. Introduction Extracellular vesicles (EVs) are heterogenous, biomolecular structures enclosed by a lipid bilayer. -
The Rita Williams Popular Song Collection a Handlist
The Rita Williams Popular Song Collection A Handlist A wide-ranging collection of c. 4000 individual popular songs, dating from the 1920s to the 1970s and including songs from films and musicals. Originally the personal collection of the singer Rita Williams, with later additions, it includes songs in various European languages and some in Afrikaans. Rita Williams sang with the Billy Cotton Club, among other groups, and made numerous recordings in the 1940s and 1950s. The songs are arranged alphabetically by title. The Rita Williams Popular Song Collection is a closed access collection. Please ask at the enquiry desk if you would like to use it. Please note that all items are reference only and in most cases it is necessary to obtain permission from the relevant copyright holder before they can be photocopied. Box Title Artist/ Singer/ Popularized by... Lyricist Composer/ Artist Language Publisher Date No. of copies Afrikaans, Czech, French, Italian, Swedish Songs Dans met my Various Afrikaans Carstens- De Waal 1954-57 1 Afrikaans, Czech, French, Italian, Swedish Songs Careless Love Hart Van Steen Afrikaans Dee Jay 1963 1 Afrikaans, Czech, French, Italian, Swedish Songs Ruiter In Die Nag Anton De Waal Afrikaans Impala 1963 1 Afrikaans, Czech, French, Italian, Swedish Songs Van Geluk Tot Verdriet Gideon Alberts/ Anton De Waal Afrikaans Impala 1970 1 Afrikaans, Czech, French, Italian, Swedish Songs Wye, Wye Vlaktes Martin Vorster/ Anton De Waal Afrikaans Impala 1970 1 Afrikaans, Czech, French, Italian, Swedish Songs My Skemer Rapsodie Duffy -
GC-Targeted C8-Linked Pyrrolobenzodiazepine−Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models Khondaker M
Article pubs.acs.org/jmc GC-Targeted C8-Linked Pyrrolobenzodiazepine−Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models Khondaker M. Rahman,† Paul J. M. Jackson,† Colin H. James,‡ B. Piku Basu,‡ John A. Hartley,§ Maria de la Fuente,‡ Andreas Schatzlein,‡ Mathew Robson,∥ R. Barbara Pedley,∥ Chris Pepper,⊥ Keith R. Fox,# Philip W. Howard,∇ and David E. Thurston*,† † Department of Pharmacy, Institute of Pharmaceutical Sciences, King’s College London, 150 Stamford Street, London SE1 9NH, United Kingdom ‡ UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX, United Kingdom § Cancer Research UK Drug−DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, United Kingdom ∥ UCL Cancer Institute, University College London, Paul O’Gorman Building, 72 Huntley Street, London WC1E 6BT, United Kingdom ⊥ Institute of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom # Centre for Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom ∇ Spirogen Ltd., QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom *S Supporting Information ABSTRACT: DNA binding 4-(1-methyl-1H-pyrrol-3-yl)- benzenamine (MPB) building blocks have been developed that span two DNA base pairs with a strong preference for GC-rich DNA. They have been conjugated to a pyrrolo[2,1- c][1,4]benzodiazepine (PBD) molecule to produce C8-linked PBD−MPB hybrids that can stabilize GC-rich DNA by up to 13-fold compared to AT-rich DNA. Some have subpicomolar IC50 values in human tumor cell lines and in primary chronic lymphocytic leukemia cells, while being up to 6 orders less cytotoxic in the non-tumor cell line WI38, suggesting that key DNA sequences may be relevant targets in these ultrasensitive cancer cell lines. -
Welcome to the UCL Community!
Welcome to the UCL community! WELCOME TO A NEW YEAR AT UCL - We're committed to making sure you can receive a world-class education and student experience in September, and that you can do so safely and with the flexibility you need. Check the UCL Students website regularly for all the latest on how we're doing this. Dear ${Contacts.First Name}, Welcome to the UCL community! We hope you’re excited about starting out on your studies and getting involved in all aspects of UCL student life. To help you get started, for our final Countdown email we’ve pulled together some useful articles on the theme of Settling In to UCL life. Next week, as the Countdown to UCL comes to an end, you’ll receive the first of our Make the Most of UCL emails. Make the Most of UCL is a six- week induction campaign, designed to help you to settle in to our community and make sure you’re fully aware of all the services and opportunities available to you. Settling In Settling in and understanding how things work at UCL won’t happen overnight! These articles will give advice and information to help you feel settled faster. The top 3 things I wish I knew when starting at UCL Find out the top 3 things one of our UCL student contributors wish they'd known when starting out at UCL. Settling back into uni when you've been away Everyone needs time to adjust to a new environment, and coming back to university after a break can feel similarly new for those returning. -
The Welfare Effects of Trade in Phytomedicines: a Multi-Disciplinary Analysis of Turmeric Production
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by SOAS Research Online The Welfare Effects of Trade in Phytomedicines: A Multi-Disciplinary Analysis of Turmeric Production AnthonyBooker ([email protected]) 1,2 Deborah Johnston ([email protected]) 1,3, Michael Heinrich ([email protected]) 1,2 1) Leverhulme Centre for Integrative Research on Agriculture and Health, (LCIRAH) 36 Gordon Square, London, WC1H 0PD, UK. 2) UCL School of Pharmacy, 29 – 39 Brunswick Square, London, WC1N 1AX, UK 3) SOAS University of London, Thornhaugh Street, Russell Square, London, WC1H 0XG, UK This research was funded by the Leverhulme Trust through a grant to LCIRAH Corresponding author: Deborah Johnston, [email protected]. Office - +44-207-898-4494 (note: no fax service). Mobile - +44-7950-494718 ABSTRACT International trade in medicinal herbal products is growing, while value chains are becoming more complex and governed by a range of public and private standards. There is a debate over the extent to which phytomedicine production can be beneficial for farmers in low and middle income countries. More generally, there are varied views about the extent to which small farmers are disadvantaged by stringent public health and private consumer standards in northern markets for agricultural products. This paper proves a comparative analysis of value chains, using case studies of turmeric production in India. It marries a qualitative investigation of turmeric producing sites in India with an investigation into the chemical quality of various turmeric products. The aim of the paper is to understand the way that varied structure and governance of value chains changes the benefits to both producer and consumer. -
Relationship-Marketing.Pdf
Relationship Marketing The Chartered Institute of Marketing/Butterworth-Heinemann Marketing Series is the most comprehensive, widely used and important collection of books in marketing and sales currently available worldwide. As the CIM’s official publisher, Butterworth-Heinemann develops, pro- duces and publishes the complete series in association with the CIM. We aim to provide definitive marketing books for students and practitioners that promote excellence in marketing education and practice. The series titles are written by CIM senior examiners and leading market- ing educators for professionals, students and those studying the CIM’s Certificate, Advanced Certificate and Postgraduate Diploma courses. Now firmly established, these titles provide practical study support to CIM and other marketing students and to practitioners at all levels. Formed in 1911, The Chartered Institute of Marketing is now the largest professional marketing management body in the world with over 60,000 members located worldwide. Its primary objectives are focused on the development of awareness and understanding of marketing throughout UK industry and commerce and in the raising of standards of profession- alism in the education, training and practice of this key business discipline. Books in the series Below-the-line Promotion, John Wilmshurst The CIM Handbook of Export Marketing, Chris Noonan The CIM Handbook of Selling and Sales Strategy, David Jobber The CIM Handbook of Strategic Marketing, Colin Egan and Michael J. Thomas CIM Marketing Dictionary (fifth -
Clinical Lecturer in Paediatrics Job Description
UCL SCHOOL OF LIFE AND MEDICAL SCIENCES UCL FACUTY OF POULATION HEALTH SCIENCES INSTITUTE OF CHILD HEALTH CLINICAL LECTURER IN PAEDIATRICS JOB DESCRIPTION INTRODUCTION The UCL Institute of Child Health (ICH) The mission of the UCL Institute of Child Health is to improve the health and well-being of children, and the adults they will become, through world-class research, education and public engagement. This strategy has been informed by the insights gained from visits to six other internationally excellent children’s academic medical centres and by detailed discussions internally and with our external partners, including GODH, GOSH Children’s Charity, the wider UCL community, UCL Partners and funding bodies. The UCL Institute of Child Health, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. In 2013 ICH developed a new academic strategy which focuses on five scientific programmes: • Genetics and Genomic Medicine • Population, Policy and Practice • Developmental Biology and Cancer • Developmental Neurosciences • Infection, Immunity and Inflammation Four key principles underpin these programmes and the academic strategy: Interdisciplinarity. ICH will facilitate the best scientists, from all relevant academic and clinical disciplines, to work together to address fundamental questions to improve the health of children. Accelerating translation. ICH will support the rapid translation of findings from basic discoveries relevant to understanding of health and disease, to clinical studies, more directly aimed at improving the clinical care of children. We will also support “reverse translation” from observations in clinical and population studies to basic studies which address mechanisms of health and disease. -
Anthony Booker Deborah Johnston and Michael Heinrich
Anthony Booker1,2 Deborah Johnston1,3 and Michael Heinrich1,2 Sowing the seeds, reaping the benefits: can an ethos of quality and ethical trading improve health in Asia and Europe? 1) Leverhulme Centre for Integrative Research on Agriculture and Health, (LCIRAH) 36 Gordon Square, London, UK 2) UCL School of Pharmacy, 29 – 39 Brunswick Square, London, UK 3) School of Oriental and African Studies, University of London, Thornhaugh Street, Russell Square, London UK UCL SCHOOL OF PHARMACY BRUNSWICK SQUARE SUMMARY TYPICAL HERBAL VALUE CHAIN CHALLENGES Assuring the quality of nutraceutical and Herbal medicines, nutraceuticals and £/Kg SUPPLY functional foods, is one of the key interfaces of herbal medicinal products is a major Land , labour, seed stock challenge to the Asian herbal industry. the pharmaceutical and nutritional sector. 0.1-1 FARM Herbal medicines are used by 35% of the fertilizer, equipment, plant Increasing quality will effect the price of population1 and the UK industry is expected to care, finance product along the length of the chain. 2 The Fairtrade approach can help to improve be worth £290 million by 2012 . The popularity of Traditional Chinese Medicines reached a quality but it is currently only a minor player in COLLECTION, peak in the 1990’s but following serious Labour, premises, equipment, the Industry. DRYING, storage, utilities adverse reactions and occurrences of poor PROCESSING For meaningful quality systems to be implemented it will be necessary to introduce quality demand declined. What are the lessons that can be learnt? Quality costs, and in a a quality ethos along the whole of the chain. -
Formulating Better Medicines for Children 10Th Conference of The
Formulating better medicines for children Meeting the needs of the children 10 th conference of the European Paediatric Formulation Initiative A conference organised by the International Association for Pharmaceutical Technology (APV) in partnership with the European Paediatric Formulation Initiative (EuPFI) 11 - 13 September 2018 · Course No. 6729 BMA House, London, United Kingdom Preconference Workshops Workshop 1: Placeboceutical: Formulation challenges in paediatric clinical trials Workshop 2: Best practices for selection of excipients for paediatrics Soap box sessions – Poster session – Exhibition Join us again for another informative and interactive conference on formulating better medicines for children. International Association for Pharmaceutical Technology Formulating better medicines for children Meeting the needs of the children Programme Wednesday, 12 September 2018, 08:30 - 18:30 PRECONFERENCE WORKSHOP Set-up and poster mounting Tuesday, 11 September 2018, 14:30 - 18:00 Welcome and Introduction Workshop 1: Placeboceutical: Formulation challenges Catherine Tuleu, University College London, School of in paediatric clinical trials Pharmacy, United Kingdom Mandy Wan, NIHR CRN: Children, United Kingdom Sandra Klein, Ernst Moritz Arndt University Greifswald, Ger - many Workshop 2: Best practices for selection of excipients for paediatrics PLENARY 1: 10yrs of EuPFI - historical review and a Kevin Hughes, Colorcon, IPEC, United Kingdom prospective glance Catherine Tuleu, University College London, School of Moderators: Pharmacy, -
Pharmacists and Medication Adherence in Asthma: a Systematic Review and Meta-Analysis
Pharmacists and medication adherence in asthma: a systematic review and meta-analysis Mes, Marissa Ayano (MSc)1, Katzer, Caroline Brigitte (MSc)1, Chan, Amy Hai Yan (PhD)1, Wileman, Vari (PhD)1, Taylor, Stephanie Jane Caroline Taylor (Professor)2, Horne, Rob (Professor)1 1Centre for Behavioural Medicine, Department for Practice and Policy, UCL School of Pharmacy, University College London – Mezzanine Floor, BMA House, Tavistock Square, London WC1H 9JP, United Kingdom 2Centre for Primary Care and Public Health, Blizard Institute, Queen Mary University London – Yvonne Carter Building, 58 Turner Street, London E1 2AB, United Kingdom Corresponding author: Miss Marissa Ayano Mes Centre for Behavioural Medicine, UCL School of Pharmacy Mezzanine Floor, BMA House Tavistock Square London WC1H 9JP United Kingdom E-mail: [email protected] Telephone: +44 (0)20 7874 1291 Take-Home Message Pharmacist-led interventions can improve medication adherence in people with asthma Word Count: 3,257 words (with headings) Tables and Figures: 5 0 Author’s contributions Marissa Ayano Mes - Study design, literature search, data collection, data analysis, data interpretation, and writing. Caroline Brigitte Katzer - Literature search, data analysis, and data interpretation. Amy Hai Yan Chan - Data analysis, data interpretation, and writing. Vari Wileman - Data analysis, data interpretation, and writing. Stephanie Jane Caroline Taylor - Study design, literature search, data interpretation, and writing. Rob Horne - Study design, literature search, data interpretation, and writing. Conflict of interest statements Ms. Mes reports grants from The National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care (NIHR CLAHRC) North Thames, during the conduct of the study; personal fees from Spoonful of Sugar Limited, outside the submitted work; and Ms. -
A M D G BEAUMONT UNION REVIEW Summer 2015
A M D G BEAUMONT UNION REVIEW Summer 2015 It might seem an odd start to The Review when I begin with a sober assessment of war. War blows away the illusion of safety from death. Some random projectile can kill you however good a serviceman you are. Escaping death and injury in the warfare of the last 100 years is much more a matter of luck-or grace – than skill, and this is a significant difference from primitive warfare. In a combat situation you wake up from sleep instantly aware that this could be the last time you awake, simultaneously grateful that you are alive and at the same time scared because you are still in the same situation. When or if they return home, the odds have changed greatly in favour of life than when in combat. It can be compared to the difference in the odds of getting killed that makes battle a noticeable experience of one’s mortality and going out for example in the car an unnoticed one. I mention this having returned from Our Great War Battlefield Tour, a report of which you will find further on and also because I have include in this issue some of the experiences of the late John Ewart (41) when on operations in Italy 1943-4. NOTICES THE BU LUNCH: Note Monday 12 October. Speakers: Henry Stevens and Mike Bedford at the Caledonian Club. VRIL: No new contribution for this quarter: ran out of time. OBITUARIES Sadly, I must inform you of the deaths of John Schulte, Vass Anderson and Gerald de Trafford; please see Obituaries.