10 SCIENTIFIC PROGRAMME
Sunday, September 2nd 2012 R E B Banqueting Hall M E
T Foyer Entrance P E S 13.00-18.00 Registration 2
, Y A D N U S
13.30- 17.00 Dr. Bert L. Schram Young Investigators’ Alexandra Mini Symposium Trianti Hall
18.00-18.30 Opening Ceremony
18.30-19.00 Leonidas Zervas Award Lecture (Sponsored by the University of Athens) From microwave heating to control of nano-scale self-assembly in peptide science Prof. Knud J. Jensen (University of Copenhagen, Denmark)
19.00-19.40 Josef Rudinger Memorial Lecture (Sponsored by Polypeptide Group) Discovery and applications of cyclotides Prof. David J. Craik (The University of Queensland, Australia)
19.40-22.00 Welcome Reception Atrium DR. BERT L. SCHRAM YOUNG 11 INVESTIGATORS’ MINI SYMPOSIUM
Sunday, September 2nd 2012 S
Alexandra Trianti U
Dr. Bert L. Schram Young Investigators’ Mini Symposium N
Hall D A Y
Chairpersons: Maria Sakarellos-Daitsiotis, Greece ,
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Dirk Tourwe, Belgium S E P
13.30-13.45 YO1: Chemoselective α-ketoacid–hydroxylamine (KAHA) ligation with T E 5-oxaproline for chemical protein synthesis M B
Dr. Vijaya Pattabiraman (ETH Zürich, Switzerland) E R 13.45-14.00 YO2: Recognition pliability is coupled to structural heterogeneity: a calmodulin - intrinsically disordered binding region complex Dr. Andreas Tzakos (University of Ioannina, Greece) 14.00-14.15 YO3: Synthesis of bicyclic 1,5-triazole-bridged vancomycin CDE-ring peptidomimics via RuAAC marcrocyclization Jinqiang Zhang (Utrecht University, The Netherlands) 14.15-14.30 YO4: Biofunctionalization of biopolymers with peptide conjugated dendrons Peter Fransen (IRB Barcelona, Spain) 14.30-14.45 YO5: The epithelial tumor marker MUC1: a versatile chemoenzymatic synthesis of posttranslationally modified variants for proteomic studies Dr. Claudia Bello (University of Vienna, Austria) 14.45-15.00 YO6: Membrane thickness and the mechanism of action of the short peptaibol trichogin GA IV Sara Bobone (Università di Roma Tor Vergata, Italy)
15.00-15.30 Coffee Break Foyer Alexandra Trianti Hall
Chairpersons: Yoshiaki Kiso, Japan Thomas Mavromoustakos, Greece 15.30-15.45 YO7: Novel sources for potent and selective GPCR modulators Dr. Markus Muttenthaler (The Scripps Research Institute, USA) 15.45-16.00 YO8: Remote control of protein function: clathrin-mediated endocytosis regulation by engineered light-switchable stapled peptides Dr. Laura Nevola (IRB Barcelona, Spain) 16:00-16:15 YO9: N-Aminosulfamide peptide mimics from aza-sulfurylglycinyl peptides: Synthesis, conformation and activity Stéphane Turcotte (Université de Montréal, Canada) 16:15-16:30 YO10: Shedding light on MHC class I antigen loading: a UV-labile peptide ligand approach Dr. Alexander Theodossis (Monash University, Australia) 16:30-16:45 YO11: An innovative strategy for direct and specific detection of intact sulfated peptides using MALDI-TOF MS reflectron positive ion mode Dr. Sonia Cantel (IBMM UMR 5247 CNRS, France) 16.45-17.00 YO12: De novo designed heterodimeric coiled coils – Useful tools for the development of new biomaterials Dr. Franziska Mende-Thomas (University of Bristol, UK) 12
Monday, September 3rd 2012
R Banqueting Hall E Session 1 Banqueting Hall B Session 1 M E
T Chairpersons: Paul Cordopatis, Greece P
E Jean Martinez, France S
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Y 08.30-09.10 PL1: Exploring the protein universe A
D Prof. Kurt Wüthrich (ETH Zürich, Switzerland and The Scripps Research N
O Institute, USA) M 09.10-09.30 O01: A total new game for the synthesis of disulfide-containing peptides Prof. Fernando Albericio (Institute for Research in Biomedicine, CIBER-BBN and University of Barcelona, Spain)
09.30-09.50 O02: Synthesis of insulin like peptides. Proposed insulin chain folding mechanism Prof. Kleomenis Barlos (University of Patras and CBL Patras, Greece)
09.50-10.10 O03: Diversity-oriented synthesis, conformational analysis and bioactivity of N-amino-imidazolin-2-one peptide mimics Prof. William D. Lubell (Université de Montréal, Canada)
10.10-10.30 O04: Bis(2-sulfanylethyl) amido native peptide ligation and novel tools for protein total synthesis Dr. Oleg Melnyk (UMR CNRS 8161, France)
10.30-11.00 Coffee Break Exhibition Hall lower level
Banqueting Hall Session 2 Chairpersons: Fernando Albericio, Spain Panagiota Moutevelis-Minakakis, Greece
11.00-11.30 IL1: D-amino acid adhesion peptides by combinatorial selection Control of cellular growth on inert surfaces Prof. Morten Meldal (University of Copenhagen, Denmark)
11.30-11.50 O05: From simple to complex to ultra complex and back to simple Dr. Michal Lebl (Spyder Institute Praha, Czech Republic)
11.50-12.10 O06: NPPS: A new intergrated method for solid phase synthesis of peptides on nanoparticles Assoc. Prof. Gerardo Byk (Bar Ilan University, Israel)
12.10-12.30 O07: Approaches to cyclic peptides and libraries of scaffolded cyclic peptides Prof. Rob M. J. Liskamp (Utrecht University, The Netherlands)
12.30-14.15 Lunch Break Allegro Restaurant 13
Monday, September 3rd 2012 M
Banqueting Hall MC2 Hall O
Session 3 Session 4 N D A
Chairpersons: Kleomenis Barlos, Greece Chairpersons: George Pairas, Greece Y ,
Paolo Rovero, Italy Botond Penke, Hungary 3
S E P
14.15-14.30 O08: Rational design and synthesis of O13: Development of a series of T E
linear and cyclic myelin epitope diketopiperazine vascular targeting M B
peptides: New directions in the anticancer agents based on E R immunotherapy of microtubule depolymerization activity multiple sclerosis Prof. Yoshio Hayashi Prof. John Matsoukas (Tokyo University of Pharmacy and (University of Patras, Greece) Life Sciences, Japan)
14.30-14.45 O09: Pseudoprolines: Effective tools O14: Branched diketo-piperazines as a for the cyclisation of small peptides universal scaffold for preparation of Prof. Katrina A. Jolliffe orally active small peptide derivatives (The University of Sydney, Australia) Prof. Vladislav Deigin (Russian Academy of Sciences, Russia)
14.45-15.00 O10: Preventing failure in difficult O15: Cell surface glycans as targets sequences: an improved resin matrix, for anti-cancer peptides its properties and application Prof. Jörg Andrä (Hamburg Dr. Wolfgang Rapp University of Applied Sciences, (Rapp Polymere GmbH, Germany) Germany)
15.00-15.15 O11: SNARE analogous peptides for O16: Design, synthesis and analysis of membrane fusion anti-tuberculosis peptides Prof. Ulf Diederichsen Dr. Vijayalekshmi Sarojini (Georg-August-University Göttingen, (University of Auckland, Germany) New Zealand)
15.15-15.30 O12: Total synthesis of marine O17: Cardioprotective peptides to cyclopeptide Scytonemin A fight against ischemia/reperfusion Assoc. Prof. Tao Ye injury in mouse hearts (The Hong-Kong Polytechnic Dr. Prisca Boisguerin University, Hong-Kong) (Université Montpellier 2, France)
15.30-16.00 Coffee Break Exhibition Hall lower level 14
Monday, September 3rd 2012
R Banqueting Hall
E MC2 Hall
B Session 5 Session 6 M E
T Chairpersons: Knud Jensen, Denmark Chairpersons: Dimitrios Gatos, Greece P
E Dirk Rijkers, Ale Narvanen, Finland S
3 The Netherlands
, Y
A 16.00-16.15 O18: Enzymatic condensation of side- O23: Mixed ion-exchange centrifugal D
N chain protected peptide fragments in partition chromatography: O
M anhydrous organic solvent using an efficient solution for peptide subtilisin A: A novel universal strategy separation for industrial peptide synthesis Prof. Jean-Hugues Renault Dr. Timo Nuijens (University of Reims Champagne- (DSM Innovative Synthesis B.V., Ardenne, France) The Netherlands) 16.15-16.30 O19: Lead optimization of O24: Conformation and biological allophenylnorstatine- containing activity of cyclolinopeptide A analogs inhibitors as therapeutic drug and modified within tetrapeptide fragment application to peptidomimic Pro-Pro-Phe-Phe protease probe Prof. Stefan Jankowski Dr. Koushi Hidaka (Lodz University of Technology, (Kobe Gakuin University, Japan) Poland) 16.30-16.45 O20: Fragment-based, photoactive O25: Solid state reaction peptides and phosphotyrosine peptide mimetics proteinswith spillover hydrogen Prof. Jörg Rademann Prof. Yurii Α. Zolotarev (Leipzig University, Germany) (Russian Academy of Sciences, Russia) 16.45-17.00 O21: Enhancing peptide activity and O26: Affinity extraction of peptides structure by synthetic constraint of in ionicliquids using click chemistry beta-turns and beta-sheets: Dr. Zhuo Li CLIPS and anti-CD40L phylomers (National Chung Cheng University, Dr. Shane R. Stone Taiwan) (Telethon Institute for Child Health Research, Australia)
17.00-17.15 O22: Development of a unique peptide O27: Design of CXCR4 Ligands for synthetic method AJIPHASE® using Diagnostic and Therapeutic anchor support molecules to suppress Applications alkylation in final cleavage step Dr. Oliver Demmer Dr. Daisuke Takahashi (Zealand Pharma A/S, Denmark) (AJINOMOTO Co, Japan)
17.15-19.30 Poster Session 1 (Posters with odd numbers) Exhibition Hall 15
Tuesday, September 4th 2012 T
Banqueting Hall U E
Seessssioionn 7 1 Banqueting Hall S D A
Chairpersons: PEarunle Csto Grdiroaplatt, iSsp, Gairneece Y ,
JWeialnli aMma rLtuinbeezl,l ,FCraanncaeda 4
S E P
08.30-09.10 PL2: The fully-extended peptide conformation T E
Prof. Claudio Toniolo (University of Padova, Italy) M B E
09.10-09.30 O28: Insight into Aβ misfolding and aggregation R Prof. Sandor Lovas (Creighton University, USA)
09.30-09.50 O29: Selective amino acid isotope labeling strategies for solution NMR studies of high-molecular-weight protein drug-targets Assoc. Prof. Georgios A. Spyroulias (University of Patras, Greece)
09.50-10.10 O30: Delivering the native structures of peptides from computer simulations and predicted NMR proton chemical shifts Dr. Pierre Tufféry (INSERM and University Paris Diderot, France)
10.10-10.30 O31: Computational prediction of bioactive peptides Prof. Denis C. Shields (University College Dublin, Ireland)
10.30-11.00 Coffee Break Exhibition Hall lower level Banqueting Hall Session 8
Chairpersons: Thomas Mavromoustakos, Greece Zbigniew Szewczuk, Poland
11.00-11.30 IL2: Ion Mobility - Mass Spectrometry and Affinity - Mass Spectrometry: New tools for elucidation of structures and reaction pathways of “misfolding” - aggregating neurodegenerative proteins Prof. Michael Przybylski (University of Konstanz, Germany)
11.30-11.50 O32: Peptides as a new emerging class of medical biomarkers Prof. Vadim T. Ivanov (Russian Academy of Sciences, Russia)
11.50-12.10 O33: Peptide self-assembled monolayers as a new tool for nanotechnology Assoc. Prof. Mariano Venanzi (University of Rome "Tor Vergata", Italy)
12.10-12.30 O34: New NMR approaches to study peptide-self-assembly in situ: principle and application to pseudodesmin, a cyclic lipodepsipeptide Prof. José C. Martins (Ghent University, Belgium)
12.30-14.15 Lunch Break Allegro Restaurant
12.30-13.30 Biotage Lunch Symposium
Further developments and systematic studies in microwave peptide synthesis Prof. Knud Jensen (University of Copenhagen, Denmark) Dr. Amit Mehrotra (Biotage, Sweden) (Gratis registration at the Symposium secretariat is required.) 16
Tuesday, September 4th 2012
R Banqueting Hall
E MC2 Hall
B Session 9 Session 10 M E
T Chairpersons:Chandralal Hewage, Ireland Chairpersons: Vaclav Cerovsky, Czech Republic P
E Theodore Tselios, Greece Jean-Alain Fehrentz, France S
4
,
Y 14.15-14.30 O35: Engineering pro-angiogenic O40: A common polymorphism in ER A
D peptides using stable disulfide-rich aminopeptidase 2 induces a specificity S
E scaffolds switch that leads to altered U T Prof. Norelle L. Daly processing of antigenic peptides (James Cook University, Austalia) Dr. Efstratios Stratikos (National Centre for Scientific Research "DEMOKRITOS", Greece) 14.30-14.45 O36: Folding landscape exploration O41: IANUS peptide array as a tool to by capping beta structures and circular screen for protein antagonists permutation Dr. Miroslav Malešević Prof. Niels Andersen (Max Planck Research Unit for (University of Washington, USA) Enzymology of Protein Folding, Germany) 14.45-15.00 O37: Lasso peptides: from linear to O42: Comprehensive peptide interlocked structures microarrays for histone research Dr. Yanyan Li Dr. Karsten Schnatbaum (Muséum National d'Histoire (JPT Peptide Technologies GmbH, Naturelle, France) Germany) 15.00-15.15 O38: Novel insulin analogues with O43: The antimicrobial peptide M33. cyclic structures mimicking the active An example of drug development conformation of the hormone at the Prof. Alessandro Pini C-terminus of the B-chain (University of Siena, Italy) Dr. Jiří Jiráček (Institute of Organic Chemistry and Biochemistry ASCR, Czech Republic)
15.15-15.30 O39: Tunable control of peptide O44: Synthesis of cyclic lipo- structure via aromatic-proline CH/π octapeptide derivatives of interactions and proline stereoelectronic burkholdines and its antifungal activity effects Assoc. Prof. Hiroyuki Konno Prof. Neal J. Zondlo (Yamagata University, Japan) (University of Delaware, USA)
15.30-16.00 Coffee Break Exhibition Hall lower level 17
Tuesday, September 4th 2012 T
Banqueting Hall U
MC2 Hall E
Session 11 Session 12 S D A
Chairpersons:Bengt Erik Haug, Norway Chairpersons: Vadim Ivanov, Russia Y ,
Leondios Leondiadis, Greece Georgios Spyroulias, Greece 4
S E P
16.00-16.15 O45: Peptides labeled by quaternary O50: On the way to synthetic peptide T E
ammonium salts for sensitive vaccine against hepatitis C M B
detection by electrospray mass Prof. Ekaterina Kolesanova E R spectrometry (Russian Academy of Medical Prof. Zbigniew Szewczuk Sciences, Russia) (University of Wroclaw, Poland) O51: A synthetic heparan sulfate- 16.15-16.30 O46: Integrated structural biology mimetic peptide conjugated to a mini shows how scarce sequence elements CD4 displays very high anti-HIV control the function of single β- activity thymosin/WH2 domains in actin assembly Dr. Françoise Baleux Dr. Eric Guittet (Institute Pasteur, France) (ICSN-CNRS, France)
16.30-16.45 O47: How hydrophobicity dictates the O52: Branched neurotensin size of self-replicating self-assembling specifically binds a highly selective macrocycles tumor cell marker, which is not Dr. Morteza Malakoutikhah neurotensin receptor 1 (University of Groningen, Dr. Chiara Falciani The Netherlands) (University of Siena, Italy)
16.45-17.00 O48: Protein-fragment complementation O53: Anticancer drug delivery and semi-rational design: Engineering systems containing GnRH-III as a specific antagonists of protein-protein targeting moiety interactions Dr. Marilena Manea Dr. Jody M. Mason (University of Konstanz, Germany) (University of Essex, UK)
17.00-17.15 O49: Food protein fragments are O54: Cis-trans isomerization in regulatory oligopeptides peptide/MHC/TCR complexes Prof. Alexander Zamyatnin Dr. Athanassios Stavrakoudis (Russian Academy of Sciences, Russia) (University of Ioannina, Greece)
17.15-19.30 Poster Session 2 (Posters with even numbers) Exhibition Hall 18
Wednesday, September 5th 2012
R Banqueting Hall E Session 13 Banqueting Hall B Session 1 M E
T Chairpersons: DPaimuli tCrioorsd oGpeaotrigsi, aGdries,e Gcereece P
E Joehan MHoawrtli,n UezK, France S
5
, 08.30-09.10 PL3: Chromatin: An expansive canvas for chemical biology Y A Prof. Tom Muir (Princeton University, USA) D S E
N 09.10-09.30 O55: Bivalent ligands for the chemokine receptor CXCR4 dimer and their function D
E Prof. Hirokazu Tamamura (Tokyo Medical and Dental University, Japan) W 09.30-09.50 O56: New azapeptide calpain inhibitors Dr. Zoltán Bánóczi (Eötvös Loránd University, Hungary)
09.50-10.10 O57: Production and characterization of matrix metalloproteinases (MMPs) implicated in multiple sclerosis (MS) Dr. Gregg B. Fields (Torrey Pines Institute for Molecular Studies, USA)
10.10-10.30 O58: Backbone cyclic helix mimetic of chemokine (C-C motif) receptor 2: A novel rational approach for inhibiting dimerization of G protein-coupled receptor Prof. Chaim Gilon (The Hebrew University of Jerusalem, Israel)
10.30-11.00 Coffee Break Exhibition Hall lower level
Session 14 Banqueting Hall Chairpersons: Vassilios Tsikaris, Greece John Wade, Australia
11.00-11.20 O59: Novel single-chain ligands for the relaxin-3 receptor RXFP3 Dr. K. Johan Rosengren (The University of Queensland, Australia)
11.20-11.40 O60: Combinatorial library of natural cyclic peptides with immunosuppres- sive properties Dr. Christian W. Gruber (Medical University of Vienna, Austria)
11.40-12.00 O61: Receptor and blood-brain barrier characterisation of opioid peptides in drug research & early development Dr. Mathieu Verbeken (Ghent University, Belgium)
12.00-18.00 Excursion (excursion pass is required)
19.00 Soccer Event and Open Field Dinner (Gratis registration at the Symposium secretariat is required) 19
Thursday, September 6th 2012
Banqueting Hall T H
Seessssioionn 1 15 Banqueting Hall U
R S
Chairpersons: VPaicutlo Cr oHrrduobpya, tUisS, AGreece D A
AJpeahnro Mdaitret iKnaepzu, Frnraiontcue, Germany Y
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6
08.30-09.10 PL4: Defying difficult diseases: design and synthesis of aspartic protease S
E P
inhibitors and click peptides based on the O-acyl isopeptide method T E
Prof. Yoshiaki Kiso (Nagahama Institute of Bio-Science and Technology, Japan) M
B E
09.10-09.30 O62: Selective cell signaling study of GPCR via PWR spectroscopy R Prof. Minying Cai (University of Arizona, USA)
09.30-09.50 O63: Present and future of peptides as blood-brain barrier shuttles Dr. Meritxell Teixido (Institute for Research in Biomedicine, Spain)
09.50-10.10 O64: Leptin receptor antagonist peptides acting in the central nervous system and the periphery Prof. Laszlo Otvos (Temple University, USA)
10.10-10.30 O65: Silencing peptides: constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes Dr. Dennis W. P. M. Löwik (Radboud University Nijmegen, The Netherlands)
10.30-11.00 Coffee Break Exhibition Hall lower level
Session 16 Banqueting Hall Chairpersons: Victoria Magrioti, Greece Anna-Maria Papini, Italy
11.00-11.30 IL3: De novo design of artificial peptides that specifically interact with HIV-1 gp41 to inhibit viral-cell membrane fusion and infection Prof. Keliang Liu (University of Beijing, China)
11.30-11.50 O66: PEGylation of the endogenous peptide Neuromedin U yields a promising candidate for the treatment of obesity and diabetes Dr. Antonello Pessi (IRBM and PeptiPharma, Italy)
11.50-12.10 O67: Peptide-derived inhibitors targeting polo-like kinase 1 for anti-cancer therapy Dr. Kyung S. Lee (National Cancer Institute, USA)
12.10-12.30 O68: Discovery and applications of circular cystine knotted peptides Assoc. Prof. Ulf Göransson (Uppsala University, Sweden)
12.30-14.15 Lunch Break Allegro Restaurant 20
Thursday, September 6th 2012
Banqueting Hall R
E Seessssioionn 1 17 Banqueting Hall B M
E Chairpersons: KPaeulila Cngo rLdioup, Cathisin, aGreece T
P EJveang Melairat iLnievza,n Fiorua,n Gcereece E S
6
, 14.15-14.30 O69: Design, synthesis and binding assays of sialic acid and sialyl-saccharide Y
A conjugates to lectins and influenza H1N1 virus D
S Prof. Maria Sakarellos-Daitsiotis (University of Ioannina, Greece) R U
H 14.30-14.45 O70: The ghrelin receptor : new potent ligands for a functional selectivity T Dr. Jean-Alain Fehrentz (Institute of Biomolecules Max Mousseron, UMR 5247, France)
14.45-15.00 O71: Understanding the structure/activity relationships of the iron regulatory peptide hepcidin Dr. Richard J. Clark (The University of Queensland, Australia)
15.00-15.15 O72: Nanoparticles-based peptide subunit vaccines against group A Streptococcus Dr. Mariusz Skwarczynski (The University of Queensland, Australia)
15.15-15.30 O73: Bioportides Dr. Sarah Jones (University of Wolverhampton, UK)
15.30-16.00 Coffee Break Exhibition Hall lower level Session 18 Banqueting Hall Chairpersons: Theodosia Maina, Greece Krzysztof Rolka, Poland
16.00-16.15 O74: Internalization of peptides and proteins into different types of live cells via formation of non-covalent complexes with cell penetrating peptides (CPPs) Prof. Siegmund Reissmann (Friedrich-Schiller-University Jena, Germany) 16.15-16.30 O75: Targeted peptide analysis: from cancer therapeutics to doping control, employing High Resolution MS strategies Dr. Martin Hornshaw (Thermo Fisher Scientific, UK) 16.30-16.45 O76: SS14-Based radiopeptides: Synthesis and biology Dr. Aikaterini Tatsi (National Centre for Scientific Research "DEMOKRITOS", Greece) 16.45-17.00 O77: Efficient identification of peptide ligands for proteins via high throughput screening of combinatorial peptide libraries Dr. Su Seong Lee (Institute of Bioengineering and Nanotechnology, Singapore) 17.00-17.15 O78: Synthesis and in vitro and in vivo evaluation of a bombesin peptide analog linked to a cytotoxic drug for the targeting of bombesin receptor-positive tumors Dr. Subhani M. Okarvi (King Faisal Specialist Hospital and Research Centre, Saudi Arabia) 20.30 Gala Dinner Vorres Museum 21
Friday, September 7th 2012 F
Banqueting Hall R I Session 19 Banqueting Hall D
Session 1 A Y ,
Chairpersons: Paul ACloerwdopoadt, iAs,u Gsrteraelciea 7
MJeoarnte Mn aMrteilndeazl,, FDreannmceark S E P T 08.30-09.10 PL5: Tumor targeting with peptides in four decades: from initial concepts to E M
an array of highly sophisticated methods B E Prof. Alex N. Eberle (University of Basel, Switzerland) R
09.10-09.30 O79: Novel approaches to the design of novel multivalent ligands for the detection and treatment of cancer Prof. Victor J. Hruby (University of Arizona, USA)
09.30-09.50 O80: Dendritic glycopeptides as Pseudomonas aeruginosa biofilm inhibitors Dr. Tamis Darbre (University of Berne, Switzerland)
09.50-10.10 O81: Development of synthetic glycopeptide vaccines for cancer therapy Prof. Yanmei Li (Tsinghua University, China)
10.10-10.30 O82: Functionalizable oligoprolines as versatile molecular scaffolds for tumor targeting Prof. Helma Wennemers (ETH Zürich, Switzerland)
10.30-11.00 Coffee Break Exhibition Hall lower level
Session 20 Banqueting Hall Chairpersons: Ferenc Hudecz, Hungary John Matsoukas, Greece
11.00-11.30 IL4: The mimicry pathway from anti-glycopeptide antibodies to specific protein antigens of immune-mediated neurodegenerative/neuroregressive diseases: the case study of Rett syndrome Prof. Anna-Maria Papini (University of Florence, Italy)
11.30-11.50 O83: Designed mimics of islet amyloid polypeptide as inhibitors of protein aggregation and cell degeneration in Alzheimer's disease and type 2 diabetes Prof. Aphrodite Kapurniotu (Technische Universität München, Germany)
11.50-12.10 O84: Safety pharmacology, pharmacokinetics and toxicology of Myrcludex B, a first-in-class hepatitis B virus entry inhibitor Prof. Walter Mier (University Hospital Heidelberg, Germany)
12.10-12.30 O85: Design and synthesis of orally active bradykinin B1 peptide antagonists for treating inflammatory pain Prof. James P. Tam (Nanyang Technological University, Singapore)
12.30-13.00 Closing Remarks 24 POSTER PRESENTATIONS
Posters 001-037: Antimicrobial Peptides, Glycopeptides and Lipopeptides
P001. P009. Alanine scan of limnonectin peptides on the Design and synthesis of amphipathic a-helical OvertureTM robotic peptide library synthesizer peptide models for the development of new J.P. Cain, M.A. Onaiyekan, C.A. Chantell, antimicrobial agents M. Menakuru A. Marianou, A. Balliu, M. Sakka, A.I. Koukkou, Μ. Sakarellos-Daitsiotis, Ε. Panou-Pomonis P002. Antimicrobial activity of new analogues of P010. Chrysophsin-1 Design, structural and functional characterization E. Tsoumani, A. Niarchos, R. Exarchakou, of a Temporin-1b analogue active against V. Mertziani, K. Poulas, P. Cordopatis, V. Magafa Gram negative bacteria C. Avitabile, F. Netti, L.D. D’Andrea, P003. M. Palmieri, G. Malgieri, R. Capparelli, Antimicrobial regulation by host defence R. Fattorusso, A. Romanelli peptides L.E. Ryan, B. Lamarre, J. Ravi, M.G. Ryadnov P011. Development of Human Cathelicidin LL-37- P004. derived Short Antimicrobial Peptides with Antimicrobially active peptides isolated from Prokaryotic Selectivity, LPS-neutralizing fleshfly larvae Activity and Protease Stability T. Neubauerov a, T. Macek, M. Šanda, S.Y. Shin, Y.H. Nan, J.K. Bang Z. Vobur̊ ka, M. Mackov a P012. P005. Effect of D-amino acid substitution on the Characterization of dual effects induced by biologically activity of the novel antimicrobial antimicrobial peptides: regulated cell death peptide from the venom of solitary bee or membrane disruption Macropis fulvipes E.J. Paredes-Gamero, M.N.C. Martins, L. Monincova,́ J. Slaninova,́ V. Fučk, F.A.M. Cappabianco, J.S. Ide, A. Miranda L. Bednaŕ ova,́ Z. Vobur̊ ka, J. Straka, P006. V. Čeřovský Conformational properties of the spin-labeled P013. tylopeptin B and heptaibin peptaibiotics based Enhanced anti-staphylococcal activity of an on PELDOR spectroscopy data analog derived from the 107-115 human M. Gobbo, B. Biondi, M. De Zotti, lysozyme fragment A.D. Milov, Yu. D. Tsvetkov, A.G. Maryasov, N.B. Iannucci, R. Gonzaĺ ez, F. Guzmań , F. Formaggio, C. Toniolo O. Cascone, F. Albericio P007. P014. Cytosolic translocation of gomesin promotes Enhancement of bacterial outer membrane cell death by endoplasmic reticulum damage, binding action of the antimicrobial peptide intracellular Ca2+ overload and magainin 2 by minimal amino acid substitution mitochondrial dysfunction S. Fukuoka, L. Heinbockel, Y. Kaconis, J. Andrä, E.J. Paredes-Gamero, R.L. Casaes-Rodrigues, M. Rössle, T. Gutsmann, K. Brandenburg G.E.D. Moura, T.M. Domingues, M.V. Buri, A. Miranda, G.Z. Justo, I.L.S. Tersariol P015. Enhancement of the anticancer activity of a P008. cationic antimicrobial peptide: an investigation De novo design of short peptides with of mechanism and structure-function relationship antimicrobial activity and the effect of acyl E. Szwej, S. O’Connor, A. Byrne, M. Devocelle, conjugation W. Gallagher, K. O’Connor A. Macurkova, R. Jezek, G. Kroneislova, P. Lovecka, T. Macek, M. Mackova POSTER PRESENTATIONS 25
Posters 001-037: Antimicrobial Peptides, Glycopeptides and Lipopeptides
P016. P024. Interaction of the antimicrobial peptide New glycopeptidic antibiotics to combat gomesin with model membranes multidrug resistant pathogens T. Domingues, B. Mattei, J. Seelig, K.R. Perez, Y. Gong, C.A. Muldoon, R. Premraj, Z.M. Ziora, K.A. Riske, A. Miranda T.A. Bradford, M. Cheng, S. Ramu, J.X. Huang, A. Kavanagh, R. Pelingon, J.C. Lee, K. Wong, P017. M.S. Butler, M.A. Blaskovich, M.A. Cooper Lipopeptides – synthesis and their properties M. Samsel, M. Kukowska, K. Dzierzbicka, P025. L. Nowicki Panurgines, novel antimicrobial peptides from the venom of wild bee Panurgus calcaratus P018. and their interaction with phospholipids Membrane disrupting antimicrobial peptide vesicles dendrimers with multiple amino termini S. Čujova,́ L. Monincova,́ J. Slaninova,́ M. Stach, T. Darbre, J-L. Reymond L. Bednaŕ ova,́ V. Čeřovský P019. P026. Membrane-activity of antimicrobial peptides Peptaibiotic folding and bioactivity: role of investigated by advanced fluorescence backbone endothioamide linkages techniques M. De Zotti*, B. Biondi, C. Peggion, M. De Poli, T. Steinberger, R. Machaň́ , M. Hof H. Fathi, S. Oancea, F. Formaggio, C. Toniolo P020. P027. Membrane-perturbing effects of antimicrobial Peptide-peptide interaction of Lactococcin G peptides: a systematic spectroscopic analysis class IIb two peptide bacteriocin D. Roversi, L. Giordano, M. De Zotti, G. Bocchinfuso, H. Etayash, W.Soliman, K. Kaur A. Farrotti, S. Bobone, A. Palleschi, Y. Park, K.-S. Hahm, F. Formaggio, C. Toniolo, L. Stella P028. Structure and biological activity of Aurein P021. 1.2 and dimeric analogues Metanicins, peptaibol antibiotics from the E.N. Lorenzοń , L.G. Nogueira, T.M. Bauab, ascomycetous fungus CBS 597.80 E.M. Cilli A. Kimonyo, H. Brückner P029. P022. Studies on the Properties and Mode of Action “Minimum bias” molecular dynamics simulations of a Synthetic Hemocidin derived from α- to determine peptide orientation in membranes Hemoglobin G. Bocchinfuso, A. Farrotti, A. Palleschi, L.A.C. Carvalho, C. Remuzgo, M.T. Machini B. Bechinger, L. Stella P030. P023. Sviceucin, a lasso peptide from Streptomyces New cell penetrating peptides designed by a sviceus: isolation and structure analysis reductionist approach enter by both direct R. Ducasse, Y. Li, A. Blond, S. Zirah, E. Lescop, translocation and endocytosis C. Goulard, E. Guittet, J-L. Pernodet, S. Rebuffat P. Lecorché, A. Walrant, S. A. Bode, P031. M. Thévenin, C. Bechara, I.D. Alves, Synthesis of PAF, an antifungal protein from S. Lavielle, G. Chassaing, S. Sagan, F. Burlina Penicillium chrysogerum by native chemical ligation G. Vaŕ adi, G. Batta, Z. Kele, G.K. Tot́ h 26 POSTER PRESENTATIONS
Posters 001-037: Antimicrobial Peptides, Glycopeptides and Lipopeptides
P032. P035. Synthesis of post-translationally modified The study of defensins of biomedical peptides for detection of autoantibodies in importance isolated from arthropods diabetic patients’ sera V. Čeřovsky,́ B. El Shazely, V. Fučíka, C. Rentier, O. Monasson, F. Nuti, P. Traldi, Z. Voburka, J. Žd’aŕ ek, J. Slaninova,́ A. Lapolla, M. Larregola, P. Rovero, A.M. Papini T. Chrudimska,́ L. Grubhoffer P033. P036. Synthesis, structure activity relationship Towards the efficient synthesis of pseudodesmin studies and antimicrobial activity of new A analogues to investigate supramolecular Tigerinins analogs structure function relationship in lipodepsipeptides F. Bédard, X. Liang, É. Godzaridis, M. De Vleeschouwer, J. Van den Begin, I. Kukavica-Ibrullj, R. Lévesques, E. Biron D. Sinnaeve, J.C. Martins, A. Madder P034. P037. The detection of Listeria monocytogenes Trichogin GA IV and selected analogs as new using a surface tethered c-terminal 24 amino antitumor agents: synthesis, conformational acid Leucocin A fragment analysis and cytotoxicity evaluation H. Etayash, L. Norman, T. Thundat, K. Kaur M. De Zotti, B. Biondi, R. Tavano, C. Peggion, F. Formaggio, E. Papini, C. Toniolo
Posters 038-052: Chemical Biology, Proteomics and Peptide Bioinformatics
P038. P042. A convenient post-screening ring opening LC-MS combined with 13C isotopic labeling as approach for the decoding of one-bead one- a toll for selective detection of advanced compound cyclic peptide libraries glycation end products A. Girard, E. Biron M. Kielmas, M. Kijewska, P. Stefanowicz, Z. Szewczuk P039. Characterizing circular peptides in mixtures: P043. sequence fragment assembly of cyclotides Multisupport synthesis and analysis of from a violet plant by MALDI-TOF/TOF mass substrates for quantification of an effect of spectrometry phosphorylation on enzymatic activity of H. Hashempour, J. Koehbach, A. Ghassempour, furin and MMP C. W. Gruber Z. Flegelova, M. Lebl, A. Strongin, P. Cieplak, S. Shirayev P040. Design and synthesis of biotinylated peptidyl P044. phosphonate probe for the isolation of single New Methods for Fluorescent Labeling of chain Fv with hydrolyzing activity Peptide Hormones and Enzyme Substrates H. Taguchi, Y. Fujita, Y. Tsuda K. Hoogewijs, D. Buyst, J. Martins, A. Madder P041. P045. Formylglycine-peptides for the identification New producers and new 11-, 19-, and 20- of novel pTyr mimetics through a fragment residue peptaibiotics: suzukacillins B and C based dynamic ligation screening (DLS) C.R. Röhrich, A. Iversen, T. Degenkolb, approach W.M. Jaklitsch, H. Voglmayr, U. Thrane, V. Martos Riano, J. Rademann A. Vilcinskas, K.F. Nielsen, H. Brückner POSTER PRESENTATIONS 27
Posters 038-052: Chemical Biology, Proteomics and Peptide Bioinformatics
P046. P049. Nonribosomal synthetases control biosynthesis, Selective/Specific substrates for HNE, CatG, structures, and evolution of peptaibol families Pr3 from microarray-based protease high- H. von Döhren, T. Degenkolb, R.K. Aghcheh, throughput screening R. Dieckmann, T. Neuhof, I.S. Druzhinina, E.N. Koini, N. Avlonitis, M. Bradley C.P. Kubicek, S.E. Baker, H. Brückner P050. P047. Targeting deubiquitinases enabled by chemical Rapid alkalinization factors in grape Vitis synthesis of proteins vinifera S. Ohayon, L. Spasser, A. Aharoni, A. Brik A.A. Zamyatnin P051. P048. Targeting N-myristoyl transferase-1 in Screening the natural habitat: New cancer using peptide microarrays1 peptaibiotics from specimens and pure cultures E. Thinon, D. Mann, E.W. Tate of the fungicolous fungus Hypocrea pulvinata C.R. Röhrich, A. Iversen, T. Degenkolb, P052. W.M. Jaklitsch, H. Voglmayr, A. Berg, U. Thrane, Theoretical analysis of the structure and A. Vilcinskas, K.F. Nielsen, H. Brückner functions of protein fragments A.A. Zamyatnin, A.S. Borchikov
Posters 053-061: Macromolecular Peptide Assemblies
P053. P057. Bis(2-sulfanylethyl)amido peptide chemistry New NMR methods to study peptide self-assembly enables a one-pot three segments ligation D. Sinnaeve, M-A. Delsuc, B. Kieffer, J.C. Martins strategy for protein chemical synthesis N. Ollivier, J. Vicogne, H. Drobecq, R. Desmet, P058. B. Leclercq, O. Melnyk Odd-even effect in the induced plasmonic CD band of peptide-capped gold nanoparticles P054. E. Longo, A. Orlandin, F. Mancin, C. Toniolo, Molecular dynamics of amylin 10-29 A. Moretto amyloid formation: parallel, antiparallel and bent structures P059. D. Lapidus, S. Ventura, C. Czaplewski, A. Liwo, Photomodulation of physicochemical properties I. Liepina in an amino acid conjugate containing eight azobenzene units P055. A. Moretto, P. Fataś , M. Mba, C. Cativiela, Molecular dynamics of amyloid formation of A.I. Jiménez, C. Toniolo two Abl-SH3 domain peptides: parallel and antiparallel beta-sheet structures P060. D. Lapidus, V. Duka, V. Stonkus, S. Ventura, Scope and limitations of bis(2-sulfanylethyl) C. Czaplewski, A. Liwo, I. Liepina amino native peptide ligation L. Raibaut, E. Lissy, O. Melnyk P056. Multivalent display of the serine protease upain-2 and its influence on binding affinity P061. Supramolecular nanovesicles formed by self- R. Roodbeen, P.A. Andreasen, K.J. Jensen assembly of a photo-switchable dipeptide A. Moretto, P. Fataś , M. Mba, C. Toniolo, C. Cativiela, A.I. Jiménez 28 POSTER PRESENTATIONS
Posters 062-070: Nanotechnology, Bioimaging and Analytical Techniques
P062. P067. Binary switch activity of the Tat peptide: Mass Spectrometry from Nanostructured from membrane penetration to lytic action materials in Proteomics S. Piantavigna, M. Abdelhamid, C. Zhao, X. Qu, C. Enjalbal, M. Dupré, S. Cantel, J. Martinez B. Graham, L. Spiccia, A. O’Mullane, L.L. Martin P068. P063. Simultaneous Determination of Aspartame, Encapsulation and radiolabeling approaches Alitame, Neotame and Advantame by HILIC- of potential peptide-type biomarkers for ESI-MS/MS assessment of amiloidal plaques related to M.G. Kokotou, C.G. Kokotos, N.S. Thomaidis the Alzheimer’s disease F.R. Cabral, C.R. Nakaie, O.P. Martins, P069. A.C. Tedesco, L. Malavolta Stability studies of peptides specific for MMP-2 as potential PET probes P064. A. Radulska, S. Ait-Mohand, V. Dumulon- End-to-end assembly of gold nanorods via a Perreault, R. Lebel, R. Zriba, B. Guérin, peptide linker W.A. Neugebauer, M. Lepage R. Roodbeen, T. Jain, N. Reeler, T. Vosch, K.J. Jensen, K. Nørgaard P070. The libraries of N-lipidated peptides P065. immobilized on cellulose as potential tools Fragmentation Patterns of Artificial Sweetener for diagnosis of malignant thyroid tumors Dipeptides by High Resolution Electrospray J. Fraczyk, W. Fendler, W. Mlynarski, Ionization Mass Spectrometry P. Wieczorek, K. Dziarkowska, W. Balcerzak, M.G. Kokotou, E. Siapi, N.S. Thomaidis, G. Kokotos Z. Kami nski P066. Generation of Silver Nanoparticles in the Presence of Oligoproline Derivatives P. Feinäugle, H. Wennemers
Posters 071-092: Neuropeptides, Peptide Hormones and Immunological Peptides
P071. P074. Charting the antiproliferative activity of Determination of in vitro T-cell stimulating [Arg8]vasopressin analogues against cancer activity of Dsg3 peptide antigens on PBMC cell lines from patients with pemphigus vulgaris V. Kounnis, A. Tzakos, E. Briasoulis, K. Uray, H. Szabados, P. Sill o, S. K arp ati, S. B osze L. Borovickov a, J. Slaninov a, P. Cordopatis, V. Magafa P075. Direct antiproliferative effect of oxytocin P072. analogues containing non natural amino acids Computer modeling of human µ-opioid receptor in positions 3 or 7 on breast cancer cells T. Dzimbova, F. Sapundzhi, N. Pencheva, V. Magafa, E. Giannopoulou, G. Pairas, P. Milanov R. Exarchakou, E. Tsoumani, L. Borovickova, J. Slaninova, H.P. Kalofonos, P. Cordopatis P073. Detection of Antibodies against Synthetic P076. Peptides Mimicking Fragments of Ureases in Evaluation of insect CAP2b analogs with Sera of Rheumatoid Arthritis Patients either an (E)-alkene, cis- or a trans-Pro B. Kolesi nska, J. Fraczyk, I. Konieczna, isostere identifies the Pro orientation for M. Kwinkowski, W. Kaca, Z. Kami nski antidiuretic activity K. Kaczmarek, F. Etzkorn, G. Coast, J. Zabrocki, R. Nachman POSTER PRESENTATIONS 29
Posters 071-092: Neuropeptides, Peptide Hormones and Immunological Peptides
P077. P085. Interaction of Enkephalins with Mixed Lipid Searching diagnosable disease using plasma Monolayers. Tensiometric and BAM Studies kisspeptin levels as a biomaker A. Tsanova, A. Jordanova, G.A. Georgiev, F. Katagiri, M. Nomizu T. Pajpanova, E. Golovinsky, Z. Lalchev P086. P078. Solid-phase syntheses of galanins [GALs] and Isolation and identification of an augurin their fragments with different strategies, peptide from bovine hypothalamus analytical data, conformations and new J-K. Chang, R-M. Lyu, X-Q. Chen, Q. Tian, S.L. biological studies Dun, N.J. Dun L. Bal aspiri, J. T oth, G. Blazs o, Z. M ajer, G.K. Toth, E. Lajk o, L. K ohidai, G. Mez o P079. JmjC-domain-containing histone demethylase P087. of the JMJD1B type as a putative precursor Structure-activity relationship of cocaine- and of human DSIP-like peptide amphetamine-regulated transcript (CART) by I.I. Mikhaleva, I.A. Prudchenko, V.T. Ivanov, peptide analogs: Importance of disulfide V.B. Voitenkov bridges M. Blechova, V. Nagelova, Z. Demianova, P080. B. Zelezna, L. Maletinska JMV 2009, a Neurotensin Analogue as Potent Antinociceptive Agent P088. A. René, P. Tétreault, N. Beaudet, P. Sarret, Structure-function analysis of the second J. Martinez, F. Cavelier extracellular loop of type 1 receptor for the corticotropin releasing factor P081. K. Spyridaki, K. Gkountelias, T. Tselios, Neuroprotective peptide Colivelin and labeled V. Magafa, R. Exarchakou, M. Papadokostaki, derivatives: Structural, in vitro and in vivo T. Mavromoustakos, G. Liapakis evaluation M. Kostomoiri, C. Zikos, D. Benaki, P089. M. Paravatou-Petsotas, T. Tsotakos, Study on the Structure Modification of Thymus C. Triantis, I. Pirmettis, M. Papadopoulos, Humoral Factor (THF-γ2) and Immunoactivity M. Pelecanou, Ε. Livaniou of the Modifided compounds H. Lin, D.X. Wang, X.X. Yang P082. New bradykinin analogues modiefied in their P090. c-terminus with d-pipecolic acid Synthesis and biological activity of cyclic M. Sleszy nska, D. Sobolewski, I. Born, peptides from cyanobacteria B. Lammek, A. Prahl F. Boyaud, I. Bonnard, B. Banaigs, A. Witczak, N. Inguimbert P083. Peptides with beta-turn structure in peptide P091. /MHC complexes Synthesis and biological studies of 2- A. Stavrakoudis naphthylalanine modification of Cyclolinopeptide A M. Kinas, K. Kierus, K. Huben, M. Zimecki, P084. S. Jankowski, J. Zabrocki Phylogenetic diversity of C-terminally expressed heptapeptide unit in opioid precursor polypeptide P092. proenkephalin A Synthesis and Conformational analysis of A. Magyar, E. Bojnik, E. Boynik, M. Corbani, linear, dimeric and cyclic analogues of the C- F. Babos, A. Borsodi, S. Benyhe terminal hexapeptide of Neurotensin C. Potamitis, P. Zoumpoulakis, R. Exarchakou, V. Mertziani, A. Spyridaki, G. Liapakis, P. Cordopatis, V. Magafa 30 POSTER PRESENTATIONS
Posters 093-121: Peptide Biochemistry and Biology
P093. P100. Aggregation and cytotoxic properties of Design, synthesis and biological evaluation of hIAPP17-29 and rIAPP17-29 fragments: a linear peptide analogs of the A2 subunit comparative study with the respective full- (Sequence 558-565) of the Factor VIII of length parent polypeptides blood coagulation F.M. Tomasello, A. Sinopoli, F. Attanasio, C. Anastasopoulos, Y. Sarigiannis, T. Campagna, G. Pappalardo G. Stavropoulos P094. Analogues of SFTI-1 as the potential P101. inhibitors of the 20S proteasome Development of potent and specific PACE4 D. Debowski, A. Mizeria, A. Lesner, A. Legowska, inhibitor K. Rolka I. Maluch, A. Kwiatkowska, Ch. Levesque, S. Routhier, R. Desjardins, F. D’Anjou, P095. W. Neugebauer, B. Lammek, A. Prahl, R. Day Angiotensin I metabolism in various kinds of fat tissue - ex vivo study in rat model of obesity P102. and insulin resistance DNA topoisomerases inhibition by peptides B. Bujak-Gi zycka, M. Suski, J. Madej, from E.coli ParE toxin B. Bystrowska, S. Zorad, L. Gajdosechov a, L.C. Bertucci Barbosa, S. Santesso Garrido, R. Olszanecki, R. Korbut L. Nascimento Santos, M. Pons, R. Marchetto P096. P103. Assessment of angiotensinogen metabolism Ex vivo assessment of angiotensin metabolism in aorta and heart of hypertensive rats in retroperitoneal and periaortic fat tissue of B. Bujak-Gi zycka, B. Bystrowska, K. Ku, hypertensive rats R. Olszanecki, R. Korbut B. Bujak-Gi zycka, M. Suski, J. Madej, K. Kus, S. Zorad, R. Olszanecki, R. Korbut P097. Biological applications of bicyclic peptides P104. E. Blattes, M. Bartoloni, T. Darbre, Hydrophobic α-Amino Acids Favour the J-L. Reymond Inhibition of Human GIIA Phospholipase A2 by 2-Oxoamides P098. S. Vasilakaki, E. Barbayianni, T.M. Mavromoustakos, Design substrates of cathepsin C using M.H. Gelb, G. Kokotos combinatorial approach M. Legowska, M. Wysocka, A Legowska, P105. K Rolka, P. Reszka, P. Bednarski, B. Korkmaz, In vitro efficacy of CcdB toxin peptide analogues F. Gauthier, A. Lesner mediated by drug delivery systems formulation S. Santesso Garrido, R. Marchetto, S. Barbosa, P099. P. Ciancaglini Design, synthesis and biological evaluation of cyclic peptide analogs of the A2 subunit P106. (Sequence 558-565) of the Factor VIII of Leishmania HslVU, an ancestral form of the 26S blood coagulation proteasome as a potential therapeutic target: C. Anastasopoulos, Y. Sarigiannis, introductory characterization G. Stavropoulos N.M. Kebe, K. Samanta, V. Apicella, N. Payrot, V. Lisowski, A. Kajava, M. Pagès, J. Martinez, P. Bastien, O. Coux, J.-F. Hernandez POSTER PRESENTATIONS 31
Posters 093-121: Peptide Biochemistry and Biology
P107. P115. N- or C-terminal biotinylated citrullin containing Study on the Application of Furan Crosslinking filaggrin epitope peptides: the effect of at the Protein-DNA Interface biotinylation on the antibody recognition in L.L.G. Carrette, M. Gattner, J. Van den Begin, Rheumatoid Arthritis T. Carell, T. Morii, A. Madder F. Babos, E. Szarka, Gy. Nagy, Z. Majer, G. S armay, A. Magyar, F. Hudecz P116. P108. Substrate specificity of human matripase- 2 New neutrophil serine proteases substrates M. Wysocka, M. Gruba, J. Popow, A. Lesner, optimized in prime positions – using the M. Gutchow, M. Stirnberg, A Legowska, K. Rolka combinatorial approach P117. J. Popow, M. Wysocka, A. Lesner, A. Legowska, Synthesis of building blocks for the synthesis K. Rolka of glycopeptides to detect anti-ganglioside P109. antibodies in Amyotrophic Lateral Sclerosis New sensitive cell permeable substrates of Y. Cao, F. Nuti, C. Tiberi, J. Uziel, P. Rovero, human proteasome A.M. Papini M. Wysocka, A. Lesner, N. Gruba, M. Kitamatsu, P118. P. Trzonowski, M. Pikula, A. Legowska, K. Rolka Synthesis of peptides and sulfated P110. monosaccharides able to identify antibodies Nonhydrolyzable Isopeptide Bond via N- in IgM monoclonal gammopathy Methylation Y. Cao, F. Nuti, G. Rossi, J. Uziel, P. Rovero, M. Haj-Yahya, N. Eltarteer, A. Brik A.M. Papini P111. P119. Peptides in Xenorhabdus and Photorhabdus spp. Towards semi-synthetic N-glucosylated MOG F.I. Nollmann, C. Dauth, D. Reimer, H.B. Bode to identify aberrantly modified native protein autoantigens in multiple sclerosis P112. M. Larregola, G. Pacini, F. Rizzolo, F. Burlina, Pharmacological characterization of circular S. Lavielle, P. Rovero, A-M. Papini plant peptides with oxytocin-like activity J. Koehbach, M. O’Brien, M. Miazzo, P120. M. Muttenthaler, M. Akcan, T.J. Smith, Transmembrane channel formation induced D.J. Craik, M. Freissmuth, C.W. Gruber by the peptaibol paracelsin from Trichoderma reesei (Hypocrea jecorini) P113. S. Gelfert-Peukert, G. Boheim, G. Jung, Specific MicroRNA Are More Produced by Dicer H. Brückner Nuclease in the Presence of Trptophan- Containing Amphiphilic Peptides P121. S. Hyun, Y. Lee, J. Yu Transporter down-regulation in a model fungal system: Cross-talk of cargo P114. ubiquitination with initiation of endocytosis Spectroscopic studies and in vitro functional A.C. Kokotos, M. Evangelinos, G. Diallinas effect of the chiral complexes of dinuclear rhodium Z. Majer, G. Szilv agyi, T. Sip ocz, N. Szoboszlai, E. Orb an, S. B osze 32 POSTER PRESENTATIONS
Posters 122-146: Peptide Ligands, Receptors and Signalling
P122. P130. Analgesic effects of novel modified with β2- Functionalized oligoprolines as multivalent tryptophan hexapeptide analogues as nociceptin scaffolds in tumor targeting receptor ligands P. Wilhelm, H. Wennemers H.H. Nocheva, A.I. Bocheva, N.D. Pavlov, P131. P.T. Todorov, E.D. Naydenova Heterofunctional dimer of endothelin ETA P123. antagonist and ETB agonist “clicked” N-terminally Binding, signaling and in vivo efficacy of on resin with second peptide component in novel peptidic CXCR4 agonists solution M. Lefrançois, M-R. Lefebvre, P. Boulais, W.A. Neugebauer, G. Bkaily, J. Labonté, G. Saint-Onge, P. Lavigne, R. Leduc, N. P. D’Orléans-Juste Heveker, E. Escher P132. P124. Medicinal chemistry approach for solid phase Chimeric peptides corresponding to intracellular synthesis of peptide mimetics of viperistatin regions of opioid receptors as “baits” for disintegrin as lead compounds for α1/α2 screening novel receptor- interacting partners integrin receptors M.P. Papakonstantinou, D.D. Fourla, T. Momic, J. Katzhendler, C. Marcinkiewicz, S.M. Vrana, Z. Georgoussi J. Eble, P. Lazarovici P125. P133. Design and Characterization of New Mimetic New antagonists of VEGFR-1: design, synthesis Peptides Involved Socss/Kinases Interaction and biochemical evaluation P. Brandi, D. Marasco, I. De Paola, R. Pastore, W-Q. Liu, S. Broussy, L. Wang, N. Eilstein, A. Angelastro, P.L. Scognamiglio M. Reille, F. Huguenot, M. Vidal P126. P134. Desulfurisation of a cyclic peptide targeting New polypeptide azemiopsin from Azemiops Death Receptor 5: Conformational outcome and feae viper venom is a ligand of nicotinic consequences on biological properties acetylcholine receptor K. Estieu-Gionnet, B. Odaert, C. Smulski, M.N. Zhmak, C. Weise, I.E. Kasheverov, V. Pavet, S. Fournel, H. Gronemeyer, G. Guichard T.V. Andreeva, E.V. Kryukova, V.G. Starkov, P127. V.I. Tsetlin, Y.N. Utkin Elucidation of the Structure-Activity Relationships of Apelin: Influence of Unnatural Amino Acids P135. on Binding, Signaling and Plasma Stability Novel neutrophil-activating cryptides hidden A. Murza, A. Parent, E. Besserer-Offroy, in mitochondrial cytochrome c H. Tremblay, F. Karadereye, N. Beaudet, Y. Hokari, T. Seki, H. Nakano, Y. Matsuo, R. Leduc, P. Sarret, E. Marsault A. Fukamizu, E. Munekata, Y. Kiso, H. Mukai P128. P136. Experimental characterization of an interaction N-terminal modifications of highly potent between 26RFa and its receptor bradykinin agonists and antagonists for J. Leprince, C. Neveu, F. Dulin, B. Lefranc, structure activity relationship and cell J. Sopkova de Oliveira Santos, L. Galas, imaging studies C. Calbrix, J. Chuquet, D. Vaudry, H. Vaudry, L. Gera, C. Roy, M-T. Bawolak, X. Charest-Morin, R. Bureau R.S. Hodges, F. Marceau P129. P137. Fluorescence spectroscopy as a tool for Peptide Based Artificial Receptors for studying protein-peptide interactions: evaluation Carbohydrate Anthrose Detection of talin affinity for β3 integrin derived peptides A. Jakas, P. Cudic, N. Bionda, J. Su c, A. Gkesouli, P. Stathopoulos, A. Psillou, K. Vlahovicek-Kahlina, M. Cudic A.S. Politou, V. Tsikaris POSTER PRESENTATIONS 33
Posters 122-146: Peptide Ligands, Receptors and Signalling
P138. or oxopyrrolidine ring in position 2 Pharmacological activity of new cyclic endomorphin A. Ambo, M. Tanaka, M. Minamizawa, Y. Sasaki analogs R. Perlikowska, J. Piekielna, J. Fichna, P143. J.C. do-Rego, A. Janecka Synthesis and structure-activity relationship studies of cyclic and peptidomimetic P139. shepherdin analogs Conformational Properties and Energetic A. Girard, E. Biron Analysis of Aliskiren in Solution and Receptor Site A. Politi, G. Leonis, H. Tzoupis, P144. D. Ntountaniotis, M.G. Papadopoulos, Synthesis of novel modified with β2- S.G. Grdadolnik, T. Mavromoustakos tryptophan haxapeptide analogues as NOP receptor ligands P140. N.D. Pavlov, P.T. Todorov, J. Martinez, Recognition of Adamantyl-anchored Mannosylated M. Calmès, E.D. Naydenova -tripeptides on Liposome Surface by Concanavaline A A. Stimac, S. Segota, M. Dutour Sikiri c, P145. R. Ribi c, L. Frkanec, V. Svetlici c, S. Tomi c, Targeting angiogenesis: VEGF receptor peptide B. Vraneci c, R. Frkanec binders R. Di Stasi, D. Diana, R. Fattorusso, P141. L.D. D’Andrea Screening Mixture Based Libraries using an Internalization Assay for the Orexin Receptor P146. C.T. Dooley, L. Li Tumor cell binding of Bombesin-like peptides C. Zikos, C.C. Liolios, C-E. Karachaliou, P142. E. A. Fragogeorgi, K. Durkan, Synthesis and biological activity of endomorphin- A.D. Varvarigou, M. Paravatou-Petsotas, 2 analogues containing isoproline, oxopiperadine E. Livaniou
Posters 147-157: Peptide Materials and Catalysts
P147. P151. Adapting to Substrate Requirements: Peptide Novel organogels based on self assembly of Catalyzed 1,4 - Addition Reactions of rationally designed pseudopeptides Aldehydes to α,β-Disubstituted Nitroolefins C. Pappas, N. Sayyad, A.G. Tzakos, J. Duschmalé, H. Wennemers I. Plakatouras P148. P152. Arginine-rich self-assembling peptides form Novel Ureas Based on Dipeptide Analogues as injectable antibacterial hydrogels Organocatalysts for the Asymmetric Aldol A.S. Veiga, C. Sinthuvanich, D. Gaspar, Reaction H.G. Franquelim, M. Castanho, J.P. Schneider P. Revelou, C. G. Kokotos, P. Moutevelis-Minakakis P149. Complex modified silaffin peptides: Versatile P153. tools for efficient enzyme immobilization Peptides characterised by the helicogenic, C.C. Lechner, C.F.W. Becker cyclic disulfide-containing α-amino acid Adt for binding studies to a metal surface P150. K. Wright, E. Longo, M. Venanzi, F. Formaggio, Novel carbon nanotube – proline based C. Toniolo organocatalyst hybrid materials D. Chronopoulos, N. Karousis, M. Tsakos, C.G. Kokotos, G. Kokotos, N. Tagmatarchis 34 POSTER PRESENTATIONS
Posters 147-157: Peptide Materials and Catalysts
P154. P156. Polymer-Supported Thiourea Catalysts for Primary Amino Acids as Organocatalysts for Enantioselective Michael Reaction the Asymmetric α-Amination of Aldehydes S. Fotaras, N. Ferderigos, G. Kokotos A. Theodorou, G.N. Papadopoulos, C.G. Kokotos P155. Primary Amine-Thioureas Based on Dipeptides P157. as Efficient Organocatalysts for Michael The Importance of Hydrogen Bonding for the Reactions Catalysis of the Enantioselective Aldol Reaction D. Limnios, D. Spanou, C. G. Kokotos, by Tripeptide-like Prolinamide Thioureas G. Kokotos S. Fotaras, C.G. Kokotos, G. Kokotos
Posters 158-198: Peptide Mimetics, Conjugates and Peptide Nucleic Acids
P158. P164. A Concise Synthesis, Docking Studies and Cu(I)- and Ru(II)-catalyzed ‘click’ macrocyclization Biological Evaluation of N-substituted 5- of tripeptides: toward vancomycin-inspired Butylimidazole Analogues as Potent Angiotensin mimics II Receptor Blockers J. Zhang, O. Longin, D. T. S. Rijkers, G. Agelis, A. Resvani, S. Durdagi, T. T umov a, R. M. J. Liskamp J. Slaninov, P. Giannopoulos, K. Spyridaki, G. Liapakis, D. Vlahakos, T. Mavromoustakos, P165. J. Matsoukas Cyclic enkephalins with a diversely substituted guanidine bridge: synthesis, and P159. biological and structural evaluation A novel synthesis of peptide-6-amino-D- Y. Touati-Jallabe, E. Bojnik, B. Legrand, luciferin conjugates for detection of peptidase E. Mauchauffée, M.-C. Averlant-Petit, activities N. N. Chung, P. W. Schiller, S. Benyhe, A. Kov acs, P. Hegyes, B. Ozsv ari, L.G. Pusk as, J. Martinez, J.-F. Hernandez G.K. T oth P166. P160. Design and synthesis of non peptide mimetics Antimicrobial peptides as novel delivery of the immunodominant 83-99 myelin basic vehicles for genetic antibiotics protein epitope (MBP83-99) G. B. Seigan, H. Franzyk, P. E. Nielsen V. Tsoulougian, I. Friligou, E. Mantzourani, T. Tselios P161. AZT-systemin conjugate translocation throughout P167. tomato plant Design and synthesis of small BACE1 inhibitor M. Dobkowski, P. Mucha, P. Rekowski peptides Y. Hamada, H. D. Tagad, Y. Kiso P162. Click-Peptides: Novel 1,2,3-Triazole Backbone P168. -Modified Peptidomimetics for Tumor Targeting Design and synthesis of the 3’-peptidyl-tRNA I. E. Valverde, A. Bauman, C. Kluba, analogues – new tools for investigation of the A. Mascarin, S. Vomstein, M. Walter, ribosome function T. L. Mindt A.G. Tereshchenkov, A. V. Golovin, A. V. Shishkina, N. V. Sumbatyan, A. A. Bogdanov P163. Convergent approaches on solid phase synthesis: Towards biomimetic transcription factors Y. Ruiz Garcia, D. Verzele, A. Madder POSTER PRESENTATIONS 35
Posters 158-198: Peptide Mimetics, Conjugates and Peptide Nucleic Acids
P169. P176. Design, Synthesis and Antinociceptive Activity Microwave assisted solid phase synthesis of of Novel Endomorphin-2 and Morphiceptin urea and urea/amide based foldamers Analogues K. Pulka, C. Douat-Casassus, G. Guichard K. Georgiev, T. Dzimbova, H. Nocheva, A. Bocheva, T. Pajpanova P177. Peptide Mediated Bacterial Drug Delivery. P170. A Mechanistic Study of Uptake and Resistance Facile and Efficient Syntheses of Structurally Towards Novel Antibiotics Modified E-urocanic Acid Analogs as Potent K.M. Olsen, T. Bentin and P. E. Nielsen Angiotensin II Receptor Blockers A. Resvani, C. Nikolis, G. Liapakis, P178. D. Vlahakos, C. Koukoulitsa, D. Ntountaniotis, Peptide-steroids chimeras synthesis and T. Mavromoustakos, J. Matsoukas, G. Agelis visualization of their binding to the rat brain slices M. Jurasek, M. Flegel, P. Skopek, Z. Flegelova, P171. P. Drasar, S. Hynie, V. Klenerova First synthesis of suitably protected PG-Phe- P179. Ψ[P(S)(OX)CH2]-Gly-PG’ as Thiophosphinyl Dipeptide Isoster (TDI) analog and comparative Rational Design, Efficient Synthesis, Biological study for selective deprotection Evaluation of New Ν,Ν΄-bis-substituted S. Vassiliou Butylimidazole Analogs as Potent Angiotensin Receptor Blockers P172. G. Agelis, A. Resvani, C. Koukoulits, Fluorescent analogues of SFTI-1 - synthesis A. Afantitis, G. Melagraki, A. Siafaka, E. Gkini, and application T. T umov a, K. Spyridaki, D. Kalavrizioti, A. Legowska, M. Wysocka, A. Lesner, M-E. Androutsou, J. Slaninov a, G. Liapakis, M. Filipowicz, A. Sieradzan, M. Pikula, D. Vlahakos, T. Mavromoustakos, J. Matsoukas P. Trzonkowski, K. Guzow, K. Rolka P180. P173. Solid phase synthesis and biological Functional mimicry of protein binding sites: evaluation of novel bifuntional opioid agonist Using CLIPS technology in combination with – neurokinin-1 antagonist peptidomimetics oxime ligation for the reconstruction of K. Guillemyn, I. Van den Eynde, A. Keresztes, discontinuous epitopes E. Varga, J. Lai, F. Porreca, E. Miclet, I. L. E. J. Smeenk, H. Hiemstra, Correia, N.N. Chung, C. Lemieux, J. Vanden J. H. van Maarseveen, P. Timmerman Broeck, P.W. Schiller, D. Tourwé, S. Ballet P174. P181. Improved submonomer method for azapeptide Structure Activity Relationship Study of (+)- synthesis applied to making aza GHRP-6 Negamycin with Readthrough-promoting analogs selective for the CD36 receptor Activity for Duchenne Muscular Dystrophy Y. Garcia-Ramos, C. Proulx, D. Sabatino, Chemotherapy S. Turcotte, P. Pohankova, H. Ong, W.D. Lubell A. Taguchi, M. Shiozuka, Y. Yamazaki, F. Yakushiji, R. Matsuda, Y. Hayashi P175. In vitro Assessment of the Cytotoxic Effects P182. of Novel RGD-mimetics Studies on a Reverse-Turn Scaffold Containing T. Dzimbova, L. Georgiev, A. Balacheva, a Thiourea Functionality I. Iliev, R. Detcheva, M. Georgieva, D. Staneva, M. Zervou, K. Paschalidou, S. Fotaras, G. Miloshev, T. Pajpanova V. Constantinou-Kokotou, G. Kokotos 36 POSTER PRESENTATIONS
Posters 158-198: Peptide Mimetics, Conjugates and Peptide Nucleic Acids
P183. P191. Synthesis and characterization of modified Synthesis, structural characterization and peptidic nucleic acids (PNAs) toward the application of crossed alkene-bridged nisin production of patterned gold surfaces to DE-Ring mimics for semi-synthesis of nisin assist cellular migration hybrid mimics V. Corvaglia, R. Marega, R. Vulcano, D. Bonifazi J.C. Slootweg, D.T.S. Rijkers, R.M.J. Liskamp P184. P192. Synthesis and docking of 4-triazolyl Targeting pre-miRNA by PNAs: a new strategy substituted piperidine derivatives as novel to interfere in the miRNA function renin inhibitors C. Avitabile, M. Saviano, L.D. D’ Andrea, R.A.G. Harmsen, A. Sivertsen, D. Michetti, N. Bianchi, E. Fabbri, E. Brognara, R. Gambari, B.O. Brandsdal, L.K. Sydnes, B.E. Haug A. Romanelli P185. P193. Synthesis of conjugates of muramyl dipeptide Tetrahydro-β-carboline-based spirocyclic and nor-muramyl dipeptide derivatives with lactam as potential type II’ β-turn somatostatine adenosine as potential immunosuppressants mimetic M. Samsel, K. Dzierzbicka, P. Trzonkowski G. Lesma, R. Cecchi, M. Musolino, P186. A. Sacchetti, A. Silvani Synthesis of CXCR4 specific peptidomimetic P194. agonists: Influence of flexible and rigid unnatural The analogues of SFTI-1 modified in the P1 amino acids on binding and signaling position by, β- and γ-amino acids and N- C. Mona, M. Lefrançois, M-R. Lefebvre, substituted β-alanines J. Cabana, P. Lavigne, N. Heveker, E. Marsault, R. Lukajtis, M. Filipowicz, A. Legowska, E. Escher D. Debowski, A. Lesner, K. Rolka P187. P195. Synthesis of new inhibitors of STAT1 mRNA Transdermal delivery: New approach in anti- as attractive compounds in treatment of hypertensive therapy atherosclerosis M. Wojciechowska, M. Alenowicz, J. Ruczynski, M. Michalatou, M.E. Androutsou, T. Tselios, P. Rekowski, M. Szelag, K. Sikorski, J. Wesoly, A. Resvani, G. Agelis, D. Vlahakos, J. Matsoukas H. Bluijssen P196. P188. Trehalose conjugated ß-sheet breaker peptides Synthesis Of N-Glycosylated-Lys ([Al18f]Nota) as stabilizers of Aß monomers. -Tyr3-Octreotate F. Attanasio, I. Naletova, V. Muronetz, Q. Qiu, F. Guo, Q. Xu, Y. Chen, T. Liu, S. Lee, A. Giuffrida, M.L. Giuffrida, F.M. Tomasello, J. Du, X. Tong F. Caraci, A. Copani, G. Pappalardo, E. Rizzarelli P189. Synthesis of triazolic nucleic acid (TNA) P197. monomers - a new class of artificial nucleic acid Use of substituted oxamide structure in designing M. Dobkowski, M. Pieszko, P. Mucha, pseudo-symmetric HIV protease inhibitors to P.Rekowski employ multiple bridging water molecules P190. K. Hidaka, Y. Toda, M. Adachi, R. Kuroki, Y. Kiso Synthesis, pharmacological evaluation and conformational investigation of endomorphin P198. -2 hybrid analogues Optimization of the PNA-synthesis using different A. Silvani, F. Airaghi, G. Balboni, E. Bojnik, bases for Fmoc-deprotection A. Borsodi, G. Lesma, S. Salvadori, T. Recca, S. Rawer, K. Braun, R. Pipkorn A. Sacchettie POSTER PRESENTATIONS 37
Posters 199-212: Peptide Synthesis Technology
P199. P206. A New Approach to the Synthesis of Peptidoglycan Novel Liquid Phase Peptide Synthesis (LPPS) Fragments Technology: Elongation Using Organic Solvent K.K. Sorensen, M.B. Thygesen, K.J. Jensen Nanofiltration (OSN) W.Q. Chen, M. Cristau, M. Giraud, P200. A.G. Livingston A Novel Reducing Agent Labile Cysteine Protecting Group P207. T.M. Postma, M. Gongora-Benitez, M. Giraud, Return of Cotton as a Carrier for Solid Phase F. Albericio Synthesis M. Lebl, Z. Flegelova P201. Comparison of Resins for Microwave Solid- P208. Phase Peptide Synthesis Scalability of Microwave-Assisted Peptide K. K. Sørensen, A. Mehrotra, K. J. Jensen Synthesis G.S. Vanier, A.D. Douglas, S.K. Singh, P202. E.J. Williamson, J.M. Collins Fast and Efficient Microwave-Assisted Monitoring of Difficult Peptide Sequences P209. F. Rizzolo, C. Testa, D. Lambardi, M. Chorev, Simplifying Native Chemical Ligation with an M. Chelli, P. Rovero, A.M. Papini N-acylsulfonamide Linker F. Burlina, C. Morris, R. Behrendt, P. White, P203. J. Offer Highly Efficient Infrared (IR) Heating Method for SPPS in Multiple Reactors With UV P210. Monitoring on the Tribute® Peptide Synthesizer Solid Phase Peptide Synthesis Via Side - Chain J.P. Cain, M.A. Onaiyekan, C.A. Chantell, Attachment on Resins of Trityl and Benzhydryl M. Menakuru Type M. Ziovas, D. Tataraki, P. Manousou, N. Parveri, P204. F. Satoglou, D. Gatos, K. Barlos In-Water Solid-Phase Peptide Synthesis uUing Fmoc Amino Acid Nanoparticles with Microwave P211. Irradiation Step-Wise Microwave-Assisted Solid-Phase K. Hojo, A. Hara, M. Onishi, H. Ichikawa, Synthesis of Proteins Y. Fukumori E. Zurita, M. Teixido, E. Giralt P205. P212. Microwave Assisted Synthesis of Complex Compatibility Study of Merrifield Linker in LysM Somains from the NFR5 Receptor in Fmoc Strategy Peptide Synthesis L. japonicus X.X. Yang, H. Lin, D. X. Wang K. K. Sørensen, K. J. Jensen 38 POSTER PRESENTATIONS
Poster 213-256: Peptide Therapeutics
P213. P220. A combined biological and theoretical study Capturing and macrophage-aided clearance of of prolyl peptides as inhibitors of angiotensin amyloid beta by surface modified proteineous I converting enzyme particles B. Yakimova, M. Rangelov, B. Tchorbanov, M. Richman, S. Rahimipour I. Stoineva P221. P214. Chemical synthesis and formulation design of A platform technology for the emergency PEGylated vasoactive intestinal peptide response to outbreaks of novel enveloped viruses derivative with high metabolic stability A. Pessi, A. Langella, E. Capito, S. Ghezzi, S. Onoue, T. Matsui, M. Kato, T. Mizumoto, E. Vicenzi, G. Poli, T. Ketas, C. Mathieu, B. Liu, L. Liu, S. Yamada B. Horvat, A. Moscona, M. Porotto P222. P215. Computational design of peptide as TrkB A stable gonadotropin releasing hormone inhibitor analogue for the treatment of endocrine M. Kafshdozi-Amin, H. Rahimib, disorders and prostate cancer M. Karimipoor, N. Gheibi T. Katsila, E. Balafas, G. Liapakis, P. Limonta, M.M. Marelli, K. Gkountelias, T. Tselios, P223. N. Kostomitsopoulos, J. Matsoukas, Design and Synthesis of Potent Linear and C. Tamvakopoulos Cyclic Dirucotide Analogues G. Deraos, K. Mauridaki, S. Deraos, T. Tselios, P216. A. Mouzaki, J. Matsoukas Analysis of psychopharmacological activity of Cortexin, Cortagen and Oleyl-cortagen P224. O.K. Granstrem, M.M. Diakonov, Design of CXCR4 Ligands for Diagnostic and T.A. Kudriavtseva, A. A. Lebedev, P.D. Shabanov Therapeutic Applications O. Demmer, I. Dijkgraaf, E. Gourni, M. P217. Schottelius, A.O. Frank, F. Hagn, L. Marinelli, Anti-peptide antibodies to synthetic fragments S. Cosconati, R. Brack-Werner, S. Kremb, of alpha7-subunit acetylcholine receptor or U. Schumacher, H.J. Wester, H. Kesslera prion protein protect cells against beta- amyloid toxicity P225. A.V. Kamynina, K.M. Holmstrom, D.O. Koroev, Development of antitumoral antibodies against O.M. Volpina, A.Y. Abramov chimeric peptides derived from adrenomedullin and its receptors P218. K. Mabrouk, C. Berenguer, C. Tesic, D. Bertin, Autoantibodies to N-glucosylated peptide P.M. Martin, L. Ouafik sequons in Rett syndrome: the first insight to disclose an autoimmune mechanism P226. F. Nuti, F. Real-Fernandez, S. Pandey, Development of new anti-prostate cancer J. Hayke, C. De Felice, S. Lavielle, agents through SAR studies of potent PACE4 M. Larregola, P. Rovero, A.M. Papini inhibitor (ML peptide) A. Kwiatkowska, C. Levesque, F. Couture, P219. R. Desjardins, S. Routhier, X.W. Yuan, Biological activity of conjugates of muramyl F. D’Anjou, W. Neugebauer, R. Day dipeptides with batracylin derivatives P. Trzonkowski, K. Dzierzbicka, J. Bociewicz, E. Szmit, M. Samsel, A. Mysliwski POSTER PRESENTATIONS 39
Poster 213-256: Peptide Therapeutics
P227. P233. Development of the first orally available Identification of Novel Anti-Thrombotic Cadherin NPFF1-R antagonist capable of reversing Derived Peptides opioid-induced hyperalgesia in rodents K. Golla, I. Stavropoulos, D.C. Shields, F. Bihel, S. Schneider, M. Schmitt, J.P. Humbert, N. Moran K. Elhabazi, G. Simonnet, E. Schneider, B. Petit-Demouliere, F. Simonin, P234. J.J. Bourguignon Improved Antiproliferative Activity of Desmopressin Analogs Assessed by Ala Scanning. P228. M.B. Pastrian, F. Guzman, G.R. Ripoll, Enhanced stability and biological properties J. Garona, M. Pifano, O. Cascone, G.N. Ciccia, of rationally designed cyclic analogues of F. Albericio, D.E. Gomez, D. F. Alonso, Luteinizing Hormone – Releasing Hormone N.B. Iannucci D. Laimou, T. Katsila, J. Matsoukas, A. Schally, K. Gkountelias, G. Liapakis, P235. C. Tamvakopoulos, T. Tselios Intrinsically Disordered Proteins (IDPs) in Neurodegenerative Diseases. P229. B. Penke, Z. Bozso, L. Fülöp Enhancement of the antiplatelet activity of novel synthetic peptides in animals receiving P236. low doses of aspirin, in an experimental Kinetic Investigations on Amide Analogues of model of arterial thrombosis Isoform 2 of Antistasin V. Moussis, C.V. Englezopoulos, K. Rousouli, D. Danalev, D. Marinkova, L. Yotova, N.D. Papamichael, V.D. Roussa, S.Tchaoushev, B. Hristova C.S. Katsouras, K.K. Naka, A.D. Tselepis, P237. L.K. Michalis, V. Tsikaris Lebetin Peptides, a Potent Platelet Aggregation P230. Inhibitors: Chemical Synthesis, Biological Evaluation of the stability and metabolism of Activity and Structure-Activity Relationships. anticancer peptides by in vitro and in vivo A. Mosbah, N. Marrakchi, M.J. Ganzalez, studies coupled with LC-MS/MS based approaches E. Giralt, M. El Ayeb, D. Bertin, D. Gigmes, T. Karampelas, C. Tamvakopoulos M Baudy Floc'h, H. Darbon, K. Mabrouk P231. P238. HIV-1 Epitopes Localizing to the Membrane Ligands that Stabilize the Amyloid β-Peptide Proximal External Region (MPER) of gp41 in a Helical Conformation Reduces Aβ Toxicity and to the V3 Loop of gp120: Syntheses and J. Maity, D. Honcharenko, Raunak, P. Bose, Immunization Assays M. Ito, L. Nilsson, J. Johansson, R. Strömberg I. Kostoula, M. Zhou, M. Hertje, E. Panou, P239. U. Dietrich, M. Sakarellos-Daitsiotis Novel Non-Covalent Staple Peptides P232. R. Zamudio-Vazquez, J. Tulla-Puche, Identification and Optimization of a Novel F. Albericio Class of HIV Fusion Inhibitors via High- P240. Throughput Synthesis & Screening of Peptide Arrays On the Mechanism of Degradation of Oxytocin W. Schepens, W. Schaaper, P. Timmerman, and its Analogues in Aqueous Solutions - Part II C. Buyck, J. Slootstra, O. Goethals, B. Stoops, K. Wisniewski, J. Finnman, M. Flipo, N. Kriek, K. Amssoms, J. Benschop, J. Wu, R. Galyean, C.D. Schteingart G. Dams, K. Van Emelen, J.W. Thuring, B. Malcolm 40 POSTER PRESENTATIONS
Poster 213-256: Peptide Therapeutics
P241. P249. Peptide Inhibitors of Integrin αIIbβ3 Activation Synthesis and Biological Evaluation of Creatinyl V. Moussis, K. Kiouptsi, A. Gourogianni, Amino Acids V. Koloka, M. Egot, C. Bachelot-Loza, S.V. Burov, M.V. Leko, M.Y. Dorosh, E. Panou-Pomonis, M. Sakarellos-Daitsiotis, O.S. Veselkina D. C. Tsoukatos, V. Tsikaris P250. P242. Synthesis and Characterization of a Synthetic Proteomic Approach to the Detection of the Antibody Targeting Cancer Cells Mechanism of Action of Anticancer Peptides K. Farbiarz, C.F.W. Becker F. Genovese, A. Gualandi, L.Taddia, M. Caselli, G. Ponterini, G. Marverti, S. Pirondi, R. Guerrini, P251. M. Pelà, G. Pavesi, C. Trapella, M.P. Costi Synthesis and Evaluation of SARS 3CL Protease Inhibitors Using the Serine Template P243. D. Takanuma, K. Akaji, H. Konno Ribavirin-Cell Penetrating Peptides Hybrid Molecules a Promising Alternative as Inhibitors of P252. Multienzyme Systems The Importance of the Cell Membrane on the R. Raykova, B. Hristova, L. Yotova, Mechanism of Action of Cyclotides N. Lubin-Germain, J. Uziel, D. Danalev S.T. Henriques, Y.-H. Huang, M.A.R.B. Castanho, N.L. Daly, D.J. Craik P244. Search for Proteins and Oligopeptides P253. The Influence of N-terminal Extremity in the Interacting to Aβ42 Utilizing Protein/Peptide Array Technology Antiplasmodial Activity of Angiotensin II D. Simon, A.M. Toth, A. Gyebrovszki, L. Fülöp, M. D. T. Torres, A. F. Silva, M. Chamlian, D.P. Virok, Z. Bozso, R. Busa-Fekete, Z. Datki, A. J. Barros, C.R. Nakaie, A. Miranda, B. Penke M.L. Capurro,V. X. Jr. Oliveira P245. P254. Selective Inhibition of Proteasome by Peptide VENOMICS Project: Peptidomics and -Based Compounds for Fine Tuning of Protein Transcriptomics of Animal Venoms for the Degradation Discovery of Novel Therapeutic Peptides A.V. Bacheva, A.A. Belogurov Jr., E.S. Kuzina, G. Upert, A. Pastor, D. Servent, G. Mourier, A.G. Gabibov N. Gilles P246. P255. Sequences of ACE-Inhibitory Precursor Analogs of RGD as Anti-Angiogenic Compounds Peptides from Bacterial Fermented Milk of T. Thi Phan, S. Abbour, Y. Arlot-Bonnemains, Camelus Dromedarius M. Baudy-Floc'h O.A. Alhaj, H. Brückner, A.S. Al-Khalifa P256. P247. Selection and Characterization of Tenascin C Short Bioactive Peptides Against Plasmodium Binding Peptide for Tumor Targeting Gallinaceum M. Young Kim, O. Kim, S. Jeong A.F. Silva, C. Maciel, M.L. Capurro, A. Miranda,V.X. Jr. Oliveira P248. Synthesis and Anticancer Activity of New Analogs of Vapreotide and RC-121 S. Staykova, E. Naydenova, D. Wesselinova, L. Vezenkov POSTER PRESENTATIONS 41
Poster 257-278: Prodrugs, Targeting and Uptake with Peptides
P257. P266. [111In/177Lu]JMV4168 for diagnosis and Neurotensin and oligo-branched peptides therapy of GRPR+-tumors decorating liposomes for selective doxorubicin T. Maina, P.J. Marsouvanidis, L.M. van der delivery Graaf, J. A. Fehrentz, B. Hajjaj, L. Brunel, D. Tesauro, A. Accardo, C. Falciani, I. Brunetti, B. A. Nock, E. P. Krenning, J. Martinez, B. Lelli, L. Bracci, G. Morelli M. de Jong P267. P258. Non-toxic delivery of siRNA by amphiphilic [111In]AT5S & [111In]AT6S: Two novel bis- peptides and silencing of hTERT disulfide bridged somatostatin-14 radiopeptides M. Fujii, S. Fujiaki with diverging biological profiles P268. A. Tatsi, R. Cescato, T. Maina, B. Waser, Retargeted Botulinum Neurotoxins using Ε. P. Krenning, M. de Jong, J.C. Reubi, SNARE protein stapling capable of selectively P. Cordopatis, B.A. Nock silencing neuroendocrine cells J. Arsenault, E. Ferrari, D. Niranjan, P259. B. Davletov Amantadine and rimantadine analogues with peptidomimetics P269. K. Chuchkov, R. Georgiev, A. S.Galabov, Short-chain fatty acid acylated daunorubicin- I. G. Stankova GnRH-III bioconjugates with enhanced cellular uptake, in vitro and in vivo antitumor activity P260. R. Hegedüs, M. Manea, E. Orban, I. Szabo, Branched and Dendritic Cell Penetrating É. Sipos, G. Halmos, B. Kapuvari, A. Schulcz, Peptides J.Tovari, G. Mezo G. Eggimann, S. Buschor, T. Darbre, P270. J.-L. Reymond Stability and biodistribution of three 111In- P261. labeled 2R-targeting peptides – A comparative Chemical stability of esters of acyclovir with study in mice A. Kaloudi, P.J. Marsouvanidis, A. Tatsi, amino acid and cholic acids E. P. Krenning, M. de Jong, B. A. Nock, K. Chuchkov, R. Chayov, I.G. Stankova T. Maina P262. P271. Comparative Evaluation of [111In-DOTA] Synthesis and characterization of a 99mTc- Analogs as Candidates for GRPR+-Tumor labeled rhodamine-conjugated angiotensin Imaging: Preclinical Results peptide as a potential cardiac function P. I. Marsouvanidis, T. Maina, E. P. Krenning, imaging agent M. de Jong, B.A. Nock S.M. Okarvi P263. Engineering and evaluation of a ribosome- P272. Synthesis and in vitro antitumor activity of display identified disulfide-constrained miniprotein new GnRH-II conjugates as scaffold for molecular imaging I. Szabo, E. Orban, Sz. Bosze, F. Zoller, A. Markert, U. Haberkorn, W. Mier B. G. de la Torre, D. Andreu, G. Mezo P264. Improving the proteolytic stability of CPP by P273. modulation of the peptide backbone Synthesis and in vitro characterization of F. Reichart, I. Neundorf peptide conjugates containing new drug candidates effective against Mycobacterium
P265. tuberculosis H37Rv Looking for the proper prodrug: A peptidomimetic Zs. Baranyai, K. Horvati, G. Mezo, approach to identify and inactivate bacterial D. Schnöller, Cs. B. Pénzes, É. Kiss, mono-ADP-ribosyltransferase toxins F. Hudecz, Sz. Boszea M. Beich-Frandsen, R. Jorgensen 42 POSTER PRESENTATIONS
Poster 257-278: Prodrugs, Targeting and Uptake with Peptides
P274. P277. Synthesis of GSH-linked tyrosinase-activated The combination of phage display and molecular melanoma prodrugs grafting gives access to a novel disulfide- P. Ruzza, A. Calderan, A. Nassi, L. Quintieri stabilized miniprotein as drug candidate F. Zoller, A. Markert, P. Barthe, U. Haberkorn, P275. W. Mier Synthesis of new hydroxycinnamoyl oseltamivir amides and evaluation of their antioxidant P278. and antiviral activities The influence of HIV-1 Tat protein sequences M. Chochkova, D. Dimitrova, G. Ivanova, on platelet activation. A. Galabov, T. Milkova P. Stathopoulos, A. A. Dimitriou, E. Malisiova, A. D. Tselepis, V. Tsikaris P276. Synthesis, in vitro and in vivo evaluation of new 99mTc-labeled cyclic RGDfK peptide monocationic complexes A. Calderan, B. Biondi, C. Bolzati, F. Refosco, N. Morellato, N. Salvarese, P. Ruzza
Poster 279-321: Structure and Conformational Studies of Peptides
P279. P284. 4-trans-Hydroxyproline analogues of Conformational and self-assembly properties of cyclolinopeptide A: synthesis, conformation cyclic lipodepsipeptides of the viscosin group and biology D. Sinnaeve, N. Geudens, J. Katarzynska, A. Wyczalkowska, K. Huben M. De Vleeschouwer, K. Feher, H. Rokni-Zadeh, J. M. Raaijmakers, R. De Mot, A. Madder, P280. J. C. Martins A cost-effective method for the preparation P285. of isotope labeled peptides for NMR studies: Conformational Similarities and Differences recombinant expression as MxeGyrA intein of Angiotensin II (AII): AII Acetate vs AII TFA fusion proteins Salt in Solution L. De Rosa, A. Russomanno, D. Diana, C. Potamitis, A. Resvanib, M-E. Androutsou, A. Romanelli, R. Fattorusso, L. D. D’Andrea M. Zervou, P. Plotas, G. Aggelis, P. Zoumpoulakis, J. Matsoukas P281. An NMR method to discriminate between the P286. fully-extended and different helical conformations Consequence of Pro Ala point mutations for in a spacer peptide peptide structure and flexibility based on the C. Peggion, M. Crisma, F. Formaggio, C. Toniolo SAA protein (86-104) fragment mutants. M. Maszota, P. Czaplewska, N. Karska, P282. M. Spodzieja, J. Ciarkowski, S. Rodziewicz- Anti-freeze peptides for potential applications Motowidlo in the food industry: molecular modelling, P287. chemical synthesis and analytical studies Design and conformational analysis of stapled C. Kong, C. Evans, V. Sarojini peptides mimicking Cullin3 binding region to P283. KCTD11. Conformational analysis of liposomal Aβ1-15 I. de Paola, L. Pirone, E. Pedone, S. Di Gaetano, derived lipopeptides by Attenuated Total L. Vitagliano, R. Fattorusso, G. Malgieri, Reflectance Infrared (ATR-IR) spectroscopy. L. Zaccaro M.P. Lopez-Deber, D. Mlaki Ndao, D.T. Hickman, P288. P. Reis, A. Pfeifer, A. Muhs How ionic liquids interact with peptides C. Mrestani-Klaus, A. Richardt, F. Bordusa POSTER PRESENTATIONS 43
Poster 279-321: Structure and Conformational Studies of Peptides
P289. P297. Identification of a novel amyloidogenic peptide On the Hydration State of Amino Acids and in the sequence of the highly amyloidogenic their Derivatives at Different Ionization Human Calcitonin States: A Comparative Multinuclear NMR and V.A. Iconomidou, P.K. Giannelou, A. Leontis, Crystallographic Investigation E.D. Chrysina, S.J. Hamodrakas C. Pappas, A.G. Tzakos, I. P. Gerothanassis P290. P298. Investigating the structural determinants of Pharmacophore model of Cysteine-based neuropeptide 26RFa required for the α4β1 Integrin Ligands based on Conformational Solution Studies activation of the receptor GPR103 M. Zervou, C. Potamitis, P. Zoumpoulakis, A. Marotte, L. Guilhaudis, Ganesan, C. Neveu, C. Fotakis, E. Papadimitriou, P. Cordopatis, B. Lefranc, J. Leprince, H. Vaudry, V. Magafa I. Ségalas-Milazzo P299. P291. Phosphorylation and OGlcNAcylation Have Local control of the peptide backbone Opposing Structural Effects in the Tau geometry using trifluoromethylated pseudoprolines Proline-Rich Domain D. Feytens, G. Chaume, G. Chassaing, N.J. Zondlo, M.A. Brister, A. A. Bielska, S. Lavielle, T. Brigaud, J.B. Byung, Y.K. Kang, A.K. Pandey E. Miclet P300. Probing Alpha-Synuclein Molecular Binding P292. Sites and their Effects on Aggregation by Memory effect in cross-seeding of amyloid NMR Spectroscopy fibrils of bovine insulin and LysB31-ArgB32 A. Byrne, M. Bisaglia, L. Bubacco, N. Andersen human insulin W. Surmacz - Chwedoruk, H. Nieznanska, P301. S. Wojcik, W. Dzwolak SAR studies of triazolyl-containing cyclopeptides: A defined -turn structure increases potency P293. and selectivity to melanocortin receptor Model of Angiotensin II bound to the AT1 subtypes receptor in the lipid bilayer environment C. Testa, D. D’Addona, M. Scrima, A.M. D’Ursi, M.T. Matsoukas, T. Tselios M. L. Dirain, M. Chorev, P. Rovero, C. Haskell-Luevano, A.M. Papini P294. P302. Modeling and simulation of peptide/MHC Scaffold Discovery by Phylomers: a novel complexes that interact both with T-cell CD40L specific scaffold derived from Glycyl receptors and antibodies tRNA Synthetase A. Stavrakoudis S.R. Stone , K. Hoffmann, N. Milech, P. T. Cunningham, M. Kerfoot, S. Winslow, P295. Y-F, Tan, M. Anastasas, C. Hall, M. Scobie, Molecular Modelling of the Kyotorphin P.Watt, R. Hopkins analogues, containing unnatural amino acids T. Dzimbova, N. Dodoff, T. Pajpanova P303. Scorpion toxins as glioprotective agents? The P296. new perspective of role of a scorpion toxin acting Monitoring peptide folding in membrane- on Kv-type channels in neurodegenerative active peptides: a time-resolved spectroscopic diseases study S. M’barek, M. El Mehdi, O. Masmoudi, E. Gatto, S. Lopez, L. Stella, G. Bocchinfuso, J. Leprince, M. Amri, J. Ben Hamida A. Palleschi, C. Serpa, F. Formaggio, C. Toniolo, M. Venanzi 44 POSTER PRESENTATIONS
Poster 279-321: Structure and Conformational Studies of Peptides
P304. P313. Screening of Synthetic Peptide Libraries by The efficient method development for the ORAC Assay for the Identification of Modified analysis of proteins, peptides, and synthetic Tetrapeptides with antioxidant properties oligonucleotides with a novel hybrid reversed A. Sandomenico, V. Severino, R. Carofaro, phase column L. Falcigno, U. Galderisi, A. Chambery , M. Ruvo F. Becker, N. Shoji, A. Matsui, C. Yokoyama, P305. T. Sato, T. Takai, N. Kuriyama Structural analysis of peptide-analogues of P314. ZP proteins with amyloidogenic properties: The fully-extended peptide conformation as Insights into mammalian zona pellucida a molecular bridge: a fluorescence investigation formation F. Formaggio, M. Crisma, G. Ballano, N.N. Louros, V.A. Iconomidou, S.J. Hamodrakas C. Peggion,M. Venanzi, C. Toniolo P306. P315. Structural Studies Of Nucleophosmin1 Helical The role of pH and acylation in surfactant Peptides protein C misfolding: an atomic point of view C. Di Natale, D. Marasco, L. De Rosa, M. Leone, C. A. Carvalheda, S. R.R. Campos, P.L. Scognamiglio, L. Vitagliano A. M. Baptista P307. P316. Structurally diverse cyclisation linkers The study of the role of the conformational impose different backbone conformations in changes at the N-terminus of the B-chain of bicyclic peptides insulin S. Chen, J. Morales-Sanfrutos, A. Angelini, L. Zakova, L. Kosinova, J. Jiracek, V. Veverka, B. Cutting, C. Heinis A. M. Brzozowski P308. P317. Study of Peptide Structural Modifications Using molecular dynamics simulations to Induced by Controlled Gamma Ray Irradiation investigate peptide dendrimers folding Experiments L.C.S. Filipe, M. Machuqueiro, A.M. Baptista R.F.F. Vieira, D.T. Nardi, N. Nascimento, J.C. Rosa, C.R. Nakaie P318. Vasopressin and vasotocin – NMR studies in P309. a membrane-mimicking environment Study of the SL21 peptide structure and its interaction with calmodulin E.A. Lubecka, E. Sikorska, F. Kasprzykowski, L. Lighezan, E. Adjadj, A. Neagu, P. Curmi, D. Sobolewski, J. Ciarkowski P310. P319. Synthesis and structure determination of Vibrational and chiroptical spectroscopic bicyclic bridged peptides investigation on diamide peptide models M. Bartoloni, T. Darbre, J-LReymond K. Knapp, M. Hollosi, E. Vass, Zs. Majer P311. P320. Temperature dictates the conformational β-Hairpin stabilization through an interstrand preference of “RGD” in peptide sequence triazole bridge “RIPRGDMP” from kistrin and selects the V. Celentano, D. Diana, L. De Rosa, C. Di Salvo, bioactive conformation A. Romanelli, R. Fattorusso, L.D. D’Andrea S. K. Upadhyay, D. Writera, Y.U. Sasidhar P321. P312. β-Phenylproline: effect of the β-phenyl The crystal structure of the 14-residue substituent on the β-turn propensity and peptaibol trichovirin at atomic resolution pyrrolidine puckering R. Gessmann, D.A. Axford, R.L. Owen, P. Fatas, A. I. Jiménez, M. I. Calaza, C. Cativiela H. Brückner, K. Petratos POSTER PRESENTATIONS 45
Poster 322-377: Synthetic Chemistry of Peptides and Amino Acids
P322. P332. 4-Methoxybenzyloxymethyl group as a thiol An expedient synthesis of guanidine-bridged protectiong group for cysteine to supress base- cyclopeptides catalyzed racemization in Fmoc chemistry X.X. Yang, H. Lin, D.X. Wang H. Hibino, Y. Nishiuchi P333. P323. Aryl hydrazine resin as a tool in the synthesis A comparison of resins for SPPS of C-terminal modified peptides – optimization J.P. Cain, M.A. Onaiyekan, C.A. Chantell, of oxidation conditions M. Menakuru I. Maluch, A. Walewska, A. Kwiatkowska, P324. B. Lammek, R. Day, A. Prahl A convenient [2+2] cycloaddition-cycloreversion reaction for the synthesis of colorful P334. peptides as new imaging chromophores Catalytic Conversion of Tertiary Amides of N. Kramer, R.M.J. Liskamp, D.T.S. Rijkers Amino Acids to Amines E. Barbayianni, G. Kokotos P325. A novel method for regioselective disulfide P335. formation in mini-proteins by kinetic oxidation Chemical stability and structure – activity control relationship studies of novel cyclic NGR T. Lindner, U. Haberkorn, W. Mier peptides G. Mezo, K. Enyedi, I. Szabo, R. Hegedüs, P326. N. Mihala, Z. Majer, A. Czajlik, E. Lajko, A Shortened Synthesis of Peptido alcohol by L. Kohidai, N. Orgovan, R. Horvath, A. Perczel HOP Strategy D.X. Wang, X.X. Yang, H. Lin P336. P327. Clickable Peptides and Their Attachment to Access to all β-phenylproline stereoisomers Oligonucleotides in enantiomerically pure form M. Wenska, M. Alvira, R. Strömberg P. Fatas, A.M. Gil, A.I. Jiménez, M.I. Calaza, P337. C. Cativiela Comparison of alternative deprotection P328. reagents to piperidine for the synthesis of a Access to cyclic or branched peptides using poly-alanine peptide on the Tribute® peptide bis (2-sulfanylethyl) amido side-chain synthesizer derivatives of Asp and Glu M.A. Onaiyekan, J.P. Cain, C.A. Chantell, E. Boll, J. Dheur, H. Drobecq, O. Melnyk M. Menakuru P329. P338. Acid-mediated prevention of aspartimide Cyclolinopeptide A analogs modified with formation in solid phase peptide synthesis pipecolic acid T. Michels, R. Dölling, U. Haberkorn, W. Mier J. Olejnik, P. Kossakowska, K. Huben, P330. J. Artym, M. Zimecki, J. Zabrocki, Alkylation of Cys-containing peptides upon S. Jankowski TFA cleavage from the Wang resin P339. P. Stathopoulos, S. Papas, Ch. Pappas, Design and synthesis of new peptide scaffold A. Tzakos,V. Moussis, V. Tsikaris presenting AGEs as diagnostic tool to monitor P331. biomarkers in diabetes Amides of antiviral drug oseltamivir with O. Monasson, F. Rizzolo, P. Traldi, A. Lapolla, antioxidant active aminoacids: synthesis and A.M. Papini biological activities M. Chochkova, G. Ivanova, A. Galabov, T. Milkova 46 POSTER PRESENTATIONS
Poster 322-377: Synthetic Chemistry of Peptides and Amino Acids
P340. P349. Design and Synthesis of Peptoid Analogues Manufacture of optically active D-allo- as AFGPs Mimics threonine from L-threonine by ARCA technology M. Ahn, R.N. Murugan, E. Kim, H. Kim, J. Bang E.S. Jeong, J. Maeng, Y.S. Ahn, M. Kim, K. M. Kim, H. Yoon, H. Lee P341. DOTA-tris(OPp ester): a novel bifunctional P350. prochelator for the preparation of DOTA- Methodological study of the peptide coupling peptide conjugates of the N-deactivated stable proline surrogate M. Jamous, U. Haberkorn, W. Mier CF3-pseudoproline G. Chaume, O. Barbeau, C. Caupène, P. Lesot, P342. D. Feytens, E. Miclet, T. Brigaud Enantiopure Trifluoromethylated Pseudoprolines: P351. Synthesis and Incorporation in Small Peptides New Building Blocks or Dendritic Pseudopeptides J. Pytkowicz, J. Simon, N. Lensen, E. Chelain, for Metal Chelating G. Chaume, T. Brigaud M. Ruan, S. Abbour, A. Mosbah, P343. M. Baudy-Floc’h Explorations in chemical ligation methodology P352. on the Prelude® peptide synthesizer New functionalized aza-β3-aminoacids for J.P. Cain, M.A. Onaiyekan, C.A. Chantell, click chemistry M. Menakuru S. Abbour, A. Mosbah, M. Baudy-Floc’h P344. P353. Exploring the space of fluorine-labeled α- N-Oligoethyleneglycol cyclic peptides amino acids for solid state 19F-NMR structure A.I. Fernandez-Llamazares, J. Spengler, analysis of peptides: rational design, F. Albericio synthesis and applications P354. P. Mykhailiuk, V. Kubyshkin, A. Tkachenko, Peptidyl-vinylketones as a novel class of D. Radchenko, S. Afonin, P. Wadhwani, inhibitors of the cysteine protease caspase-3 S. Grage,O. Babii, I. Komarov, A. S. Ulrich K. Holland-Nell, J. Rademann P345. P355. Fast conventional Fmoc solid-phase peptide Ring-closing metathesis and ‘click’ cyclization synthesis: a comparative study of different of astressin-derived peptides as novel activators on the Symphony® peptide synthesizer corticotropin releasing factor antagonists C.A. Chantell, M.A. Onaiyekan, J.P. Cain, A. Al Temimi, R.M.J. Liskamp, D.T.S. Rijkers M. Menakuru P356. P346. Role of cation-pi interaction in the photolysis Fmoc-SPPS based synthesis of bioactive of disulphide bridge containing cyclic model cyclic peptides via N-acylurea intermediates peptides S. Gunasekera, U. Göransson E. Illyés, K. Knapp, G. Csik, Z. Majer P347. P357. Free Side-Reaction Wang Linker Simple and efficient solid-phase preparation of azido-peptides V. Castro, H. Rodriguez, F. Albericio M.B. Hansen, T.H.M. van Gurp, P348. J.C.M. van Hest, D.W.P.M. Löwik Fully automated click cyclization of a cancer- P358. targeting peptide on the Prelude® peptide Site-Selective Three-Component Double synthesizer Functionalization of Peptides and Proteins J.P. Cain, M.A. Onaiyekan, C.A. Chantell, H.K. Munch, J.E. Rasmussen, J.B. Christensen, M. Menakuru K.J. Jensen POSTER PRESENTATIONS 47
Poster 322-377: Synthetic Chemistry of Peptides and Amino Acids
P359. P368. SPPS of glucosylated multiple antigen peptides Synthetic Study of Callipeltin B Analogues (MAPs) as synthetic probes for detection of and its Cytotoxicity autoantibodies in multiple sclerosis patients’ M. Kikuchi, Y. Watanabe, M. Tanaka, K. Akaji, sera H. Konno C. Tiberi, G. Sabatino, M. Di Pisa, P. Rovero, P369. A.M. Papini Targeting protein-protein interactions using P360. small peptides for treatment of disease Synthesis and preliminary characterisation of K. Keeling, A. Abell, K. Wegner, G. Booker, a nitronyl nitroxide α-amino acid D. Scanlon, L. Martin K. Wright, J. Scola, A. Toffoletti, F. Formaggio, P370. C. Toniolo Templating cyclic β-tripeptides: combination of inhibitor and recog-nition P361. motifs with fluorescence labeling and cell Synthesis of (2R,3R)-N -Fmoc-3-TBDMSilyloxy penetrating units - aspartic acid-allyl ester. H. Radzey, F. Stein, U. Diederichsen F. Boyaud, N. Inguimbert P371. P362. Three-Component Synthesis of Neoglycopeptides Synthesis of diastereoisomeric modified Using a Cu(II)-Triggered Aminolysis of amino acids derived from -lipoic acid for use Peptide Hydrazide Resin and an Azide-Alkyne in solid phase peptide synthesis Cycloaddition Sequence C. Rentier, F. Nuti, G. Pacini, P. Rovero, J.-P. Ebran, N. Dendane, O. Melnyk C. Selmi, A.M. Papini P372. P363. Total chemical synthesis of calstabin 2 protein Synthesis of Homopolypeptides with PPII M. Jullian, O. Melnyk, J.A. Boutin, L. Ronga, Structure K. Puget C. Martin, J. Martinez, F. Cavelier P373. P364. UPLC-based amino acid analysis of paintings Synthesis of newly designed peptides for the and statistical analysis of chromatographic profiles for conservation of cultural heritage diagnosis of Celiac Disease G. Sabatino, F. Di Pisa, M. Potenza, L. Dei, M. Di Pisa, G. Sabatino, M. Chelli, P. Rovero, A.M. Papini A.M. Papini P374. P365. Use of Internal References for the Quantitative Synthesis of N-OEG analogs of the Sansalvamide HPLC-UV Analysis of Solid-Phase Reactions A peptide and evaluation of their biological J. Spengler, A.I. Fernandez-Llamazares, activity F. Albericio A.I. Fernandez-Llamazares, J. Spengler, V. Soto-Cerrado, R. Pérez-Tom as, F. Albericio P375. α-Ketoacid–hydroxylamine (KAHA) ligation for P366. the chemical synthesis of modifier proteins Synthesis of O-Glycopeptides Using N, N’- A.O. Ogunkoya, V.R. Pattabiraman, J.W. Bode Isopropylidene Dipeptide Derivatives P376. H. Kobayashi, T. Inazu ß2-Microglobulin: a “difficult” protein P367. S. Abel, M. Beyermann Synthetic approaches for the development of P377. cell penetrating conjugates linked through Synthesis of Peptide Mimetic Inhibitors thioether or disulfide bond Targeting Polo-Box Domain of Polo-like S. Papas, E. Sereti, A.A. Dimitriou, Kinase 1 Ch. Papadopoulos, V. Moussis, A.D. Tselepis, J.K. Bang, Y.S. Song, J.E. Park, R.N. Murugan, V. Tsikaris M. Ahn, K.S. Lee 48 POSTER PRESENTATIONS
Poster 378-399: Various Topics
P378. P386. A synthetic 83 amino acid long peptide Fused 1,2-Isoxazoles and Phthalazines as Anchor corresponding to the minimal metacaspase Heterocyclic Scaffolds for the Construction of catalytic domain induces cell death in Cell-Penetrating Peptide Sequences Leishmania major P.G. Tsoungas, G. Pairas, P. Cordopatis C. Servis, H. Zalila, I. Gonzalez, L. Lozano, N. Fasel P387. Keratin and Collagen models as a tool in the P379. deterioration of works of art Affecting Peptides Folding and Functionality E. Fotou, I. Kostoula, S. Zevgiti, within Synthetic Networks by External E. Panou-Pomonis, G. Panagiaris, Triggers M. Sakarellos-Daitsiotis S. Alasibi, G. Ashkenasy P388. P380. New biphasic solvent systems for the Condensation Of Peptides With Dienophiles purification of non-ionic synthetic hydrophobic L. Sklyarov, I. Nazimov, R. Ziganshin, V. Zaikin, peptides by Centrifugal Partition Chromatography S. Andreev N. Amarouche, L. Boudesoque, M. Giraud, A. Butte, F. Quattrini, J-H. Renault P381. Development of a novel structural vaccinology P389. strategy for epitope discovery for the Spectroscopic investigation of the interaction Burkholderia pseudomallei OppA antigen of curcumin with the β-amyloid peptide of A. Gori, P. Lassaux, C. Peri, M. Ferrer-Navarro, Alzheimer’s disease L. Gourlay, R. Longhi, O. Conchillo-Solé, D. Benaki, K. Stamatakis, L. Leondiadis, D. Rinchai, G. Lertmemongkolchai, X. Daura, E. Mikros, M. Pelecanou M. Bolognesi, G. Colombo P390. P382. Synthesis and anticancer activies of lypophilic Cyanoethyl thioesters as precursors for the somatostatin derivatives facile synthesis of peptide thioacids for H. Inazumi, T. Suyama, D. Takami, K. Hidaka, application in ligation reactions A. Miyazaki, T. Yokoi, I. Kuriyama, H. Yoshida, R. Raz, J. Rademann Y. Mizushina, Y. Tsuda P383. P391. Development and validation of a UPLC- MS Synthesis of an anthraquinone type compound analytical method for the control of the conjugated to the immunodominant 35-55 conjugation of [Lys-Gly]5-MOG35-55 with myelin oligodendrocyte glycoprotein (MOG35-55) mannan I. Friligou, A. Tapeinou, J. Matsoukas, T. Tselios M.E. Androutsou, I. Friligou, J. Matsoukas, T. Tselios P392. Synthesis of privileged scaffolds: mimicking P384. 1,5-benzodiazepine-2,4-diones via a modular Elastin like polypeptides (ELP): synthesis, approach on solid-phase characterization and application in enzyme F. Backaert, J. Lunagariya, J. Caroen, purification J. Van der Eycken F. Aladini, C.F.W. Becker P393. P385. Twenty-five years in European Peptide Enhanced sialic acid content of recombinant Symposia soccer events erythropoietin by a chemical method L. Bal aspiri, M. Manning E. Omidinia, A. Kianmehr, M. Ghanbari, H. Shahbaz Mohammadi, R. Rashid Pouraie POSTER PRESENTATIONS 49
Poster 378-399: Various Topics
P394. P397. hLF1-11 synthesis and immobilization onto Peptide-Epitope mapping and reactivity of the chitosan thin films to create antimicrobial autoantigen Aquaporin-4 coatings H. Alexopoulos, E.I. Kampylafka, H.M. F. Costa, S. Maia, P. Gomes, M.C.L. Martins Moutsopoulos, M.C. Dalakas and A.G. Tzioufas P395. Design and synthesis of N-methyl derivatives P398. of Urotensin-II Chemoselective α-ketoacid–hydroxylamine (KAHA) F. Merlino, S. Di Maro, P. Campiglia, ligation with 5-oxaproline for chemical protein P. Santicioli, S. Meini, C.A. Maggi, synthesis E. Novellino, P. Grieco V.R. Pattabiraman, A.O. Ogunkoya, J.W. Bode P396. P399. Tetras Asynchronous Multiple Peptide Instrument N-Aminosulfamide Peptide Mimics from Aza- C. Li, T. Justice, O.J. Kreuzer sulfurylglycinyl Peptides: Synthesis, Conformation and Activity S. Turcotte, S. H. Bouayad-Gervais, T. Havard, W. D. Lubell