DOCSLIB.ORG

Colorectal Cancer Source: Globocan 2020

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Colorectal Cancer Source: Globocan 2020 Colorectal cancer Source: Globocan 2020 Number of new cases in 2020, both sexes, all ages Number of deaths in 2020, both sexes, all ages Breast 2 261 419 (11.7%) Lung 1 796 144 (18%) Lung Other cancers 2 206 771 (11.4%) 3 557 464 (35.7%) Other cancers 8 275 743 (42.9%) Colorectum Colorectum 1 931 590 (10%) 935 173 (9.4%) Prostate Prostate Liver 1 414 259 (7.3%) 375 304 (3.8%) 830 180 (8.3%) Oesophagus Stomach Pancreas Stomach 604 100 (3.1%) 1 089 103 (5.6%) 466 003 (4.7%) 768 793 (7.7%) Cervix uteri Liver Oesophagus Breast 604 127 (3.1%) 905 677 (4.7%) 544 076 (5.5%) 684 996 (6.9%) Total: 19 292 789 cases Total: 9 958 133 deaths Cancer incidence and mortality statistics worldwide and by region Incidence Mortality Both sexes Males Females Both sexes Males Females Cum. risk Cum. risk Cum. risk Cum. risk Cum. risk Cum. risk New cases New cases New cases Deaths Deaths Deaths 0-74 (%) 0-74 (%) 0-74 (%) 0-74 (%) 0-74 (%) 0-74 (%) Eastern Africa 18 306 0.92 8 888 1.00 9 418 0.85 13 236 0.67 6 365 0.74 6 871 0.62 Middle Africa 5 767 0.80 3 045 0.90 2 722 0.72 4 228 0.59 2 222 0.67 2 006 0.53 Northern Africa 20 858 1.10 10 662 1.17 10 196 1.03 11 530 0.56 5 900 0.60 5 630 0.52 Southern Africa 7 684 1.57 3 919 1.93 3 765 1.30 3 943 0.79 2 052 1.00 1 891 0.64 Western Africa 13 583 0.74 7 546 0.88 6 037 0.63 9 938 0.56 5 507 0.66 4 431 0.47 Caribbean 11 454 2.04 5 327 2.13 6 127 1.97 6 983 1.08 3 307 1.18 3 676 0.98 Central America 19 535 1.19 10 181 1.37 9 354 1.03 10 439 0.61 5 494 0.72 4 945 0.51 South America 103 954 2.09 51 710 2.35 52 244 1.86 52 013 0.95 26 175 1.11 25 838 0.82 Northern America 180 575 2.98 95 138 3.38 85 437 2.61 63 987 0.87 34 105 1.05 29 882 0.70 Eastern Asia 757 849 3.00 431 501 3.64 326 348 2.37 368 072 1.23 208 090 1.57 159 982 0.91 South-Eastern Asia 106 995 1.70 60 505 2.11 46 490 1.33 57 064 0.82 32 205 1.06 24 859 0.62 South-Central Asia 102 987 0.63 61 252 0.76 41 735 0.50 59 206 0.36 35 848 0.44 23 358 0.27 Western Asia 41 569 1.97 23 496 2.35 18 073 1.63 22 107 0.97 12 382 1.18 9 725 0.79 Central and Eastern Europe 172 950 3.63 89 189 4.75 83 761 2.85 93 384 1.72 48 378 2.38 45 006 1.26 Western Europe 141 644 3.27 77 052 3.95 64 592 2.65 62 266 1.06 34 113 1.37 28 153 0.77 Southern Europe 123 588 3.76 71 009 4.81 52 579 2.81 55 406 1.22 31 583 1.60 23 823 0.88 Northern Europe 81 638 3.89 44 464 4.52 37 174 3.31 33 768 1.16 17 811 1.38 15 957 0.96 Australia and New Zealand 19 644 3.70 10 491 4.24 9 153 3.18 7 038 0.87 3 755 1.13 3 283 0.63 Melanesia 804 1.32 466 1.66 338 1.01 452 0.75 279 0.99 173 0.53 Polynesia 113 1.90 68 2.41 45 1.40 60 1.14 37 1.36 23 0.93 Micronesia 93 2.07 51 2.55 42 1.63 53 1.21 29 1.64 24 0.84 Low HDI 37 923 0.84 19 616 0.94 18 307 0.76 27 443 0.62 14 173 0.69 13 270 0.55 Medium HDI 129 206 0.70 74 698 0.85 54 508 0.56 74 912 0.40 43 769 0.49 31 143 0.31 High HDI 812 972 2.39 455 544 2.86 357 428 1.94 421 087 1.10 237 016 1.38 184 071 0.85 Very high HDI 950 563 3.42 515 616 4.15 434 947 2.77 411 289 1.15 220 443 1.47 190 846 0.87 World 1 931 590 2.25 1 065 960 2.71 865 630 1.83 935 173 0.94 515 637 1.18 419 536 0.73 Incidence, both sexes Mortality, both sexes 5-year prevalence, both sexes Africa Africa Africa (3.4%) (4.6%) (2.5%) LAC** N.America* LAC** (7%) (6.8%) (6.6%) Asia Asia N.America* LAC** Asia N.America* (49.9%) (9.3%) (52.3%) (7.4%) (54.2%) (10.6%) Europe Europe Europe (26.9%) (26.2%) (29.2%) Population Number Population Number Population Number Asia 1 009 400 Asia 506 449 Asia 2 622 900 Europe 519 820 Europe 244 824 Europe 1 536 168 *Northern America 180 575 **Latin America and the Caribbean 69 435 *Northern America 554 680 **Latin America and the Caribbean 134 943 *Northern America 63 987 **Latin America and the Caribbean 345 715 Africa 66 198 Africa 42 875 Africa 130 338 Oceania 20 654 Oceania 7 603 Oceania 63 534 Total 1 931 590 Total 935 173 Total 5 253 335 The Global Cancer Observatory - All Rights Reserved, December, 2020. Page 1 Age standardized (World) incidence rates, colorectal cancer, males, all ages ≥ 35.0 23.0–35.0 15.2–23.0 10.2–15.2 Not applicable 6.8–10.2 No data < 6.8 Age standardized (World) incidence rates, colorectal cancer, females, all ages ≥ 22.8 17.3–22.8 11.9–17.3 7.8–11.9 Not applicable 5.7–7.8 No data < 5.7 Data source: GLOBOCAN 2020 Graph production: IARC (https://gco.iarc.fr/today) World Health Organization © International Agency for Research on Cancer 2020 Age standardized (World) incidence rates, colorectal cancer, by sex Age standardized (World) incidence and mortality rates, colorectal cancer Males Females Incidence Mortality Southern Europe 40.6 24.5 Northern Europe 33.6 11.4 Northern Europe 39.2 28.8 Australia and New Zealand 33.2 9.5 Central and Eastern Europe 38.4 23.4 Southern Europe 31.9 11.5 Australia and New Zealand 37.4 29.2 Central and Eastern Europe 29.3 14.5 Western Europe 34.3 23.9 Western Europe 28.7 10.2 Eastern Asia 31.2 21.0 Northern America 26.2 8.2 Northern America 29.4 23.4 Eastern Asia 25.9 11.8 World 23.4 16.2 World 19.5 9.0 South America 20.6 16.8 South America 18.5 8.9 Western Asia 19.9 14.0 Caribbean 18.2 10.4 Micronesia 19.5 14.2 Western Asia 16.8 8.9 Polynesia 19.2 11.9 Micronesia 16.6 9.5 Caribbean 18.5 17.8 Polynesia 15.5 8.4 South-Eastern Asia 18.4 11.9 South-Eastern Asia 14.8 7.9 Southern Africa 16.7 11.7 Southern Africa 13.7 7.2 Melanesia 14.2 9.0 Melanesia 11.4 6.7 Central America 12.0 9.1 Central America 10.4 5.5 Northern Africa 10.4 9.1 Northern Africa 9.7 5.4 Eastern Africa 8.6 7.5 Eastern Africa 7.9 5.9 Western Africa 7.9 5.7 Middle Africa 6.8 5.2 Middle Africa 7.7 6.1 Western Africa 6.7 5.1 South-Central Asia 6.6 4.4 South-Central Asia 5.5 3.2 60 40 20 0 20 40 60 50 40 30 20 10 0 10 20 30 40 50 ASR (World) per 100 000 ASR (World) per 100 000 The Global Cancer Observatory - All Rights Reserved, December, 2020. Page 2.
Load more

Recommended publications
  • Does Liver Cirrhosis Affect the Surgical Outcome of Primary Colorectal
    Cheng et al. World Journal of Surgical Oncology (2021) 19:167 https://doi.org/10.1186/s12957-021-02267-6 RESEARCH Open Access Does liver cirrhosis affect the surgical outcome of primary colorectal cancer surgery? A meta-analysis Yu-Xi Cheng†, Wei Tao†, Hua Zhang, Dong Peng* and Zheng-Qiang Wei Abstract Purpose: The purpose of this meta-analysis was to evaluate the effect of liver cirrhosis (LC) on the short-term and long-term surgical outcomes of colorectal cancer (CRC). Methods: The PubMed, Embase, and Cochrane Library databases were searched from inception to March 23, 2021. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of enrolled studies, and RevMan 5.3 was used for data analysis in this meta-analysis. The registration ID of this current meta-analysis on PROSPERO is CRD42021238042. Results: In total, five studies with 2485 patients were included in this meta-analysis. For the baseline information, no significant differences in age, sex, tumor location, or tumor T staging were noted. Regarding short-term outcomes, the cirrhotic group had more major complications (OR=5.15, 95% CI=1.62 to 16.37, p=0.005), a higher re- operation rate (OR=2.04, 95% CI=1.07 to 3.88, p=0.03), and a higher short-term mortality rate (OR=2.85, 95% CI=1.93 to 4.20, p<0.00001) than the non-cirrhotic group. However, no significant differences in minor complications (OR= 1.54, 95% CI=0.78 to 3.02, p=0.21) or the rate of intensive care unit (ICU) admission (OR=0.76, 95% CI=0.10 to 5.99, p=0.80) were noted between the two groups.
    [Show full text]
  • Risk of Colorectal Cancer and Other Cancers in Patients with Gall Stones
    Gut 1996; 39:439-443 439 Risk of colorectal cancer and other cancers in patients with gall stones Gut: first published as 10.1136/gut.39.3.439 on 1 September 1996. Downloaded from C Johansen, Wong-Ho Chow, T J0rgensen, L Mellemkjaer, G Engholm, J H Olsen Abstract Although the relation between cholecystec- Background-The occurrence of gall tomy and colorectal cancer has been con- stones has repeatedly been associated with sidered in many studies, the results are equi- an increased risk for cancer of the colon, vocal"; most of the case-control studies but risk associated with cholecystectomy showed a positive relation, but only the two remains unclear. largest cohort studies showed significantly Aims-To evaluate the hypothesis in a increased risks, which were restricted to nationwide cohort ofmore than 40 000 gall women and to the proximal part of the stone patients with complete follow up colon.'4 15 including information of cholecystectomy These results suggest that gall stones, and and obesity. possibly cholecystectomy, which are done Patients-In the population based study mainly as a result ofgall stones increase the risk described here, 42098 patients with gall for colon cancer, particularly among women stones in 1977-1989 were identified in the and in the proximal part of the colon. One Danish Hospital Discharge Register. hypothesis is that post-cholecystectomy Methods-These patients were linked to changes in the composition and secretion of the Danish Cancer Registry to assess their bile salts affect enterohepatic circulation and risks for colorectal and other cancers exposure of the colon to bile acids,'6 '` which during follow up to the end of 1992.
    [Show full text]
  • Review of Intra-Arterial Therapies for Colorectal Cancer Liver Metastasis
    cancers Review Review of Intra-Arterial Therapies for Colorectal Cancer Liver Metastasis Justin Kwan * and Uei Pua Department of Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore 388403, Singapore; [email protected] * Correspondence: [email protected] Simple Summary: Colorectal cancer liver metastasis occurs in more than 50% of patients with colorectal cancer and is thought to be the most common cause of death from this cancer. The mainstay of treatment for inoperable liver metastasis has been combination systemic chemotherapy with or without the addition of biological targeted therapy with a goal for disease downstaging, for potential curative resection, or more frequently, for disease control. For patients with dominant liver metastatic disease or limited extrahepatic disease, liver-directed intra-arterial therapies including hepatic arterial chemotherapy infusion, chemoembolization and radioembolization are alternative treatment strategies that have shown promising results, most commonly in the salvage setting in patients with chemo-refractory disease. In recent years, their role in the first-line setting in conjunction with concurrent systemic chemotherapy has also been explored. This review aims to provide an update on the current evidence regarding liver-directed intra-arterial treatment strategies and to discuss potential trends for the future. Abstract: The liver is frequently the most common site of metastasis in patients with colorectal cancer, occurring in more than 50% of patients. While surgical resection remains the only potential Citation: Kwan, J.; Pua, U. Review of curative option, it is only eligible in 15–20% of patients at presentation. In the past two decades, Intra-Arterial Therapies for Colorectal major advances in modern chemotherapy and personalized biological agents have improved overall Cancer Liver Metastasis.
    [Show full text]
  • Sporadic (Nonhereditary) Colorectal Cancer: Introduction
    Sporadic (Nonhereditary) Colorectal Cancer: Introduction Colorectal cancer affects about 5% of the population, with up to 150,000 new cases per year in the United States alone. Cancer of the large intestine accounts for 21% of all cancers in the US, ranking second only to lung cancer in mortality in both males and females. It is, however, one of the most potentially curable of gastrointestinal cancers. Colorectal cancer is detected through screening procedures or when the patient presents with symptoms. Screening is vital to prevention and should be a part of routine care for adults over the age of 50 who are at average risk. High-risk individuals (those with previous colon cancer , family history of colon cancer , inflammatory bowel disease, or history of colorectal polyps) require careful follow-up. There is great variability in the worldwide incidence and mortality rates. Industrialized nations appear to have the greatest risk while most developing nations have lower rates. Unfortunately, this incidence is on the increase. North America, Western Europe, Australia and New Zealand have high rates for colorectal neoplasms (Figure 2). Figure 1. Location of the colon in the body. Figure 2. Geographic distribution of sporadic colon cancer . Symptoms Colorectal cancer does not usually produce symptoms early in the disease process. Symptoms are dependent upon the site of the primary tumor. Cancers of the proximal colon tend to grow larger than those of the left colon and rectum before they produce symptoms. Abnormal vasculature and trauma from the fecal stream may result in bleeding as the tumor expands in the intestinal lumen.
    [Show full text]
  • Colorectal Cancer Facts
    134 Park Central Square (703) 548-1225 Suite 210, Springfield, MO 65806 FightCRC.org MARCH 2021 – COLORECTAL CANCER FACTS March is Colorectal Cancer Awareness Month. Let’s spread the word that colorectal cancer (CRC) is preventable with screening and treatable if caught early. STATS AND FACTS ABOUT COLORECTAL CANCER (CRC) #1: 1 IN 23 MEN AND 1 IN 25 WOMEN WILL BE DIAGNOSED. • In 2021, the American Cancer Society estimates that there will be 104,270 new cases of colon cancer and 45,230 cases of rectal cancer. • There are over one million colorectal cancer survivors in the U.S. #2: CRC IS THE SECOND-LEADING CAUSE OF CANCER DEATHS AMONG MEN AND WOMEN COMBINED IN THE U.S. • 52,980 deaths from colorectal cancer are expected in 2021. • At its most treatable (stage I), it’s 90% curable. But only 38% of CRCs are diagnosed at stage I. • For those diagnosed before age 50, around 10% have late-stage disease (stages III and IV). #3: CRC IS PREVENTABLE WITH SCREENING AND AFFORDABLE TAKE-HOME OPTIONS EXIST. • 68% percent of deaths could be prevented with screening. • The American Cancer Society Guidelines recommend screening starting at 45 years old. • Always consult your doctor about which screening method is right for you. #4: FAMILY HISTORY OF CRC = HIGHER RISK = GET SCREENED EARLIER! Take our family history quiz at FightCRC.org/ • Between 25-30% of CRC patients have a family history of the disease. FamilyHistoryQuiz. #5: BY KNOWING THE RISK FACTORS AND SIGNS AND SYMPTOMS, YOU CAN CATCH IT AT ITS EARLIEST STAGE.
    [Show full text]
  • Synchronous Primary Colonic and Early Gallbladder Carcinomas: Report of a Rare Case
    http://crcp.sciedupress.com Case Reports in Clinical Pathology, 2015, Vol. 2, No. 1 CASE REPORT Synchronous primary colonic and early gallbladder carcinomas: report of a rare case Zainab I. Alruwaii1, Mohamed A. Shawarby2 1. Histopathology Department, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia. 2. Pathology Department, College of Medicine, University of Dammam, Dammam, Saudi Arabia. Correspondence: Mohamed A. Shawarby. Address: Pathology Department, College of Medicine, University of Dammam, Dammam 31441, Saudi Arabia. E-mail: [email protected] Received: August 13, 2014 Accepted: October 7, 2014 Online Published: October 15, 2014 DOI: 10.5430/crcp.v2n1p48 URL: http://dx.doi.org/10.5430/crcp.v2n1p48 Abstract The incidence of multiple primary malignant tumors in the same individual is increasing worldwide. We report a case of a 30 years old female with an adenocarcinoma of the colon in whom a high grade dysplasia/carcinoma in situ of the gallbladder was incidentally discovered in the cholecystectomy specimen resected with the colon for multiple gall stones. Synchronous adenocarcinomas of the colon and the gallbladder are extremely rare with only seven cases reported so far. The link between the colonic and the gall bladder carcinoma may reside in the presence of gall stones rather than a hereditary predisposition to cancer development as may be suggested by a negative family history for colorectal and gallbladder cancers. Because the colon is the organ that is most frequently involved in the setting of multiple primary malignant tumors, thorough preoperative screening and follow up for other cancers, including gallbladder cancer, is recommended for patients presenting with colorectal carcinoma.
    [Show full text]
  • Intussusception Reveals MUTYH-Associated
    Mesquita et al. BMC Cancer (2019) 19:324 https://doi.org/10.1186/s12885-019-5505-8 CASEREPORT Open Access Intussusception reveals MUTYH-associated polyposis syndrome and colorectal cancer: a case report Gustavo Heluani Antunes de Mesquita1*, Bárbara Justo Carvalho1, Kayo Augusto de Almeida Medeiros1, Fernanda Nii1, Diego Ramos Martines1, Leonardo Zumerkorn Pipek1, Yuri Justi Jardim1, Daniel Reis Waisberg2, Marcos Takeo Obara3, Roberta Sitnik3, Alberto Meyer2,3 and Cristóvão Luis Pitangueiras Mangueira4 Abstract Background: We are reporting a rare case of MUTYH-associated polyposis, a colorectal cancer hereditary syndrome, diagnosticated after an intussusception. Colorectal cancer is an important cause of cancer related mortality that can be manifested by an intussusception, a rare occurrence in adults and almost always related to tumors. Approximately 5% of colorectal cancers can be attributed to syndromes known to cause hereditary colorectal cancer, such as MUTYH- associated polyposis, autosomal genetic syndrome associated with this disease. Case presentation: We present the case of a 44 years old male, that sought medical consultation with a complaint of abdominal discomfort, that after five days changed its characteristics. The patient was sent to the emergency department were a CT-scan revealed intestinal sub-occlusion by ileocolic invagination. Right colectomy was carried out. The anatomic- pathological examination revealed a moderately differentiated mucinous adenocarcinoma and multiples sessile polyps, which led to the suspicion of a genetic syndrome. In the genetics analysis two mutations were observed in the MUTYH gene, and MUTYH-associated polyposis was diagnosticated. Conclusion: This case demonstrates the importance of meticulous analysis of the patient examinations results to identify possible discrete alterations that can lead to improved understanding of disease.
    [Show full text]
  • Guidelines for the Management of Oesophageal and Gastric Cancer
    Guidelines Guidelines for the management of oesophageal and gastric cancer William H Allum,1 Jane M Blazeby,2 S Michael Griffin,3 David Cunningham,4 Janusz A Jankowski,5 Rachel Wong,4 On behalf of the Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, the British Society of Gastroenterology and the British Association of Surgical Oncology 1Department of Surgery, Royal INTRODUCTION earlier version, with some evidence provided in Marsden NHS Foundation Trust, Over the past decade the Improving Outcomes detail to describe areas of development and to London, UK 2 Guidance (IOG) document has led to service support the changes to the recommendations. The School of Social and fi Community Medicine, University re-con guration in the NHS and there are now 41 editorial group (WHA, JMB, DC, JAJ, SMG and of Bristol, Bristol, UK specialist centres providing oesophageal and gastric RW) have edited the individual sections, and the 3Northern Oesophago-Gastric cancer care in England and Wales. The National final draft was submitted to independent expert Unit, Royal Victoria Infirmary, Oesophago-Gastric Cancer Audit, which was review and modified. The strength of the evidence Newcastle upon Tyne, UK 6 4 supported by the British Society of Gastroenter- was classified guided by standard guidelines. Gastrointestinal Oncology Unit, Royal Marsden NHS Foundation ology, the Association of Upper Gastrointestinal Trust, London, UK Surgeons (AUGIS) and the Royal College of Categories of evidence 5Department of Oncology, Surgeons of England Clinical Effectiveness Unit, Ia: Evidence obtained from meta-analysis of rand- University of Oxford, Oxford, UK and sponsored by the Department of Health, has omised controlled trials (RCTs).
    [Show full text]
  • Unusual Causes of Large Bowel Obstruction
    Current Problems in Surgery 56 (2019) 49–90 Contents lists available at ScienceDirect Current Problems in Surgery journal homepage: www.elsevier.com/locate/cpsurg Unusual causes of large bowel obstruction ∗ Nicholas G. Farkas, MBBS, MRCS , Ted Joseph P. Welman, BSc, MBBS, MRCS, Talisa Ross, MBChB, BSc, Sarah Brown, MB, BCH, BAO, BSc, Jason J. Smith, MD, DMI, FRCS (General Surgery), Nikhil Pawa, MD, LLM, MSc, FRCS Introduction Large bowel obstruction (LBO) is defined as a surgical emergency where a mechanical inter- ruption (either complete or partial) occludes the flow of intestinal contents. 1 Understanding the varying etiologic causes of LBO is important for clinicians and surgeons when tailoring manage- ment to each patient. Knowledge of large bowel anatomy, embryology, and pathophysiology is vital when investigating and treating LBO. Many clinicians will have encountered patients with LBO on a ward or in the operating room and will appreciate the challenges posed by such presentations. Although less common than small bowel obstruction (25% of all intestinal obstructions 2 ) LBO poses more immediate risks in the form of perforation and subsequent peritonitis. Establishing the cause of an obstruction is paramount, given the high associated morbidity and mortality, 3 in order to facilitate the guid- ance of treatment. Recent studies highlight high morbidity and mortality rates of 42% to 46% and 13% to 19%, respectively, following operation. 3,4 LBO accounts for nearly 2% to 4% of all surgical admissions. 5 Colonic malignancy remains the most common cause of LBO, representing approximately 60% of cases. 3,6 Other prevalent etiolo- gies relate to adhesions, diverticulosis, hernia, inflammatory bowel disease (IBD), and volvulus.
    [Show full text]
  • NCCN Guidelines for Patients Colon Cancer
    NCCN GUIDELINES FOR PATIENTS® 2021 Colon Cancer Presented with support from: Available online at NCCN.org/patients Ü Colon Cancer It's easy to get lost in the cancer world Let NCCN Guidelines for Patients® be your guide 9 Step-by-step guides to the cancer care options likely to have the best results 9 Based on treatment guidelines used by health care providers worldwide 9 Designed to help you discuss cancer treatment with your doctors NCCN Guidelines for Patients® Colon Cancer, 2021 1 About NCCN Guidelines for Patients® are developed by the National Comprehensive Cancer Network® (NCCN®) NCCN Clinical Practice NCCN Guidelines NCCN Guidelines in Oncology for Patients (NCCN Guidelines®) 9 Developed by doctors from 9 Present information from the 9 An alliance of leading NCCN cancer centers using NCCN Guidelines in an easy- cancer centers across the the latest research and years to-learn format United States devoted to of experience patient care, research, and 9 For people with cancer and education 9 For providers of cancer care those who support them all over the world Explain the cancer care Cancer centers 9 options likely to have the that are part of NCCN: 9 Expert recommendations for best results NCCN.org/cancercenters cancer screening, diagnosis, and treatment Free online at Free online at NCCN.org/patientguidelines NCCN.org/guidelines NATIONAL COMPREHENSIVE CANCER NETWORK FOUNDATION Guiding Treatment. Changing Lives. and supported by funding from NCCN Foundation® These NCCN Guidelines for Patients are based on the NCCN Guidelines® for Colon Cancer, Version 2.2021 – January 21, 2021. © 2021 National Comprehensive Cancer Network, Inc.
    [Show full text]
  • Epidemiological Studies on Peutz-Jeghers Syndrome & Lynch Syndrome
    Hereditary colorectal cancer syndromes Epidemiological studies on Peutz-Jeghers syndrome & Lynch syndrome Margot van Lier Colofon ISBN 978-94-6169-031-9 Financial support for printing this thesis was kindly given by Zambon Nederland BV, ABBOTT Immunology, Tramedico, Dr. Falk Pharma Benelux BV, Bayer BV, Merck Sharp & Dohme BV, PENTAX Nederland BV, Gerrit Blaauw fonds, J.E. Jurriaanse Stichting, de Nederlandse Vereni- ging voor Gastroenterologie, the department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, and the Erasmus University, Rotterdam Lay out: Optima Grafische Communicatie, Rotterdam, The Netherlands Printed by: Optima Grafische Communicatie, Rotterdam, The Netherlands Coverdesign, -concept and -illustration: Stan W.H. van Lier http://www.stanvanlier.nl [email protected] © Margot G. F. van Lier, The Netherlands 2011 All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, without prior permission of the author. Hereditary colorectal cancer syndromes: Epidemiological studies on Peutz-Jeghers syndrome & Lynch syndrome Erfelijke colorectaal kanker syndromen: Epidemiologische studies naar het Peutz-Jeghers syndroom en het Lynch syndroom Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus Prof.dr. H.G. Schmidt en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op 25 maart 2011 om 11.30 uur door Margot Gerarda Franka van Lier geboren te Nijmegen ProMotiecommissiE Promotoren: Prof.dr. E.J. Kuipers Prof.dr. E.W. Steyerberg Overige leden: Prof.dr. M.J. Bruno Prof.dr. J.F. Lange Prof.dr. E.M.H. Mathus-Vliegen Copromotoren: Dr.
    [Show full text]
  • Pancreatic Neuroendocrine Tumors Fact Sheet
    Pancreatic Neuroendocrine Tumors Fact Sheet Pancreatic Neuroendocrine Tumors Tumors of the neuroendocrine system are typically classified into two distinct categories: carcinoids or pancreatic neuroendocrine tumors. Pancreatic neuroendocrine tumors form in the endocrine (hormone-producing) tissues of the pancreas and are also sometimes known as pancreatic islet cell tumors.1,2 Pancreatic neuroendocrine tumors are called "functioning" if they produce hormones that result in clinical symptoms associated with excessive hormone release or "nonfunctioning" if they do not. Most functioning tumors are benign, while more than 50 percent of nonfunctioning tumors are likely to be malignant.1,3 Nonfunctioning pancreatic neuroendocrine tumors produce clinical symptoms from the primary tumor bulk or from metastatic dissemination.4 Because nonfunctioning tumors do not produce symptom inducing hormones, they are often advanced before they are discovered.3 Pancreatic neuroendocrine tumors are different from exocrine tumors of the pancreas (pancreatic adenocarcinoma), which account for about 95 percent of all pancreatic cancers.5 Pancreatic neuroendocrine tumors are slow growing tumors3 that are fairly rare and are reported in two to four people per million annually worldwide6,7 and account for approximately 22-28 percent of all neuroendocrine tumors.8,9 The incidence of pancreatic neuroendocrine tumors appears to be rising, due in part to heightened awareness of the disease, improved diagnostic techniques and an increased rate of incidental diagnoses during evaluations for other conditions.10,11 For patients with pancreatic neuroendocrine tumors that have metastasized, prognosis is poor, with a survival of only 1-3 years,12 similar to that seen with metastatic breast cancer or metastatic colon cancer.13,14 Pancreatic Neuroendocrine Tumors Subtypes There are several subtypes of pancreatic neuroendocrine tumors.
    [Show full text]