Chapter 1 Ashkenazi Jews
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Mishpacha-Article-February-2011.Pdf
HANGING ON BY A FRINGCOLONE:EL MORDECHAI FRIZIS’S MEMBERS COURAG THEEOUS LA SRESPONSET ACT OF THE TRIBE? FOR HIS COUNTRY OPEN MIKE FOR HUCKABEE SWEET SONG OF EMPATHY THE PRESIDENTIAL HOPEFUL ON WHAT FUELED HIS FIFTEENTH TRIP TO ISRAEL A CANDID CONVERSATION WITH SHLOIME DACHS, CHILD OF A “BROKEN HOME” LIFEGUARD AT THE GENE POOL HIS SCREENING PROGRAM HAS SPARED THOUSANDS FROM THE HORROR OF HIS PERSONAL LOSSES. NOW DOR YESHORIM’S RABBI YOSEF EKSTEIN BRAVES THE STEM CELL FRONTIER ON-SITE REPORT RAMALLAHEDUCATOR AND INNOVATOR IN RREALABBI YAAKOV TIME SPITZER CAN THES P.TILLA. FORM LIVA FISCESALLY RSOUNDAV STATE?WEI SSMANDEL’S WORDS familyfirst ISSUE 346 I 5 Adar I 5771 I February 9, 2011 PRICE: NY/NJ $3.99 Out of NY/NJ $4.99 Canada CAD $5.50 Israel NIS 11.90 UK £3.20 INSIDE The Gene Marker's Rabbi Yosef Ekstein of Dor Yeshorim Vowed that No Couple Would Know His Pain Bride When Rabbi Yosef Ekstein’s fourth Tay-Sachs baby was born, he knew he had two options – to fall into crushing despair, or take action. “The Ribono Shel Olam knew I would bury four children before I could take my self-pity and turn it outward,” Rabbi Ekstein says. But he knew nothing about genetics or biology, couldn’t speak English, and didn’t even have a high school diploma. How did this Satmar chassid, a shochet and kashrus supervisor from Argentina, evolve into a leading expert in the field of preventative genetic research, creating an Bride international screening program used by most people in shidduchim today? 34 5 Adar I 5771 2.9.11 35 QUOTES %%% Rachel Ginsberg His father, Rabbi Kalman Eliezer disease and its devastating progression, as Photos: Meir Haltovsky, Ouria Tadmor Ekstein, used to tell him, “You survived by the infant seemed perfect for the first half- a miracle. -
Tay Sachs Disease Testing
Autosomal recessive mutations Genetic diseases & testing The story of three genetic diseases Phenylketonuria Reading: Chapter 12; and pp 201-202 Sickle-Cell Anemia Tay-Sachs Disease Phenylketonuria (PKU), Sickle-Cell Anemia and Tay-Sachs Disease are autosomal Frequencies of Sickle-Cell Anemia and Tay- recessive diseases. Sachs Disease alleles in different populations. carrier Disease is expressed in Sickle-Cell Anemia matings between carriers 10-40% of the population in regions of equatorial (heterozygotes). Africa are carriers <1% of South Africans are carriers Most affected individuals have unaffected parents. Tay-Sachs Increased frequency with 1/25 American Ashkenazi Jews are carriers inbreeding. 1/300 in the general population are carriers Why are the frequencies of some Hemoglobin disease alleles so high? Major protein in red blood cells. Hemoglobin is made of four Explanation #1 polypeptide chains--2 alpha and Heterozygote advantage 2 beta chains--and four heme- iron complexes. These complexes bind O2. Explanation #2 Founder effect Hemoglobin releases CO2 and binds O2 when CO2 concentrations are low. i.e., in the lungs. Hb binds CO2 and releases O2 when CO2 concentrations high. A single amino acid change in the beta peptide results in sickle cell anemia Why is the carrier frequency so high? Carriers have an advantage in malaria-infested areas Genotype disease malaria HbA/HbA normal susceptible HbA/HbS normal resistant Tay Sachs The Founder Effect Progressive disease with an onset in infancy of developmental retardation, followed by paralysis, dementia and blindness. Death occurs in the second or third year of life. Tay-Sachs disease is caused by mutation in the hexosaminidase A gene, which removes fatty substances called gangliosides. -
Rabbi Goren and the Disintegration of the Rabbanut • Chava Ginsburg Was Born in A
Rabbi Goren and the Disintegration of the Rabbanut https://www.youtube.com/watch?v=ggljfAfREjU • Chava Ginsburg was born in a small town in Poland in the early 1920s. At around 14 years old, she met and eloped with a Polish Christian man, who, after converting, took the name Avraham Borokovsky. After living for a few months in Poland, the Borokovskys made Aliyah along with Chava’s parents sometime in the 1930’s. • Soon after they arrived in Israel, Chava and Avrohom’s marriage fell apart and they separated without obtaining a Get. This became problematic when Chava did not disclose this fact to the Beit Din that issued a license for her to marry her second husband, Otto Langer, in 1944. Two children, Chanoch and Miriam, were born to Otto and Chava Langer. • In 1951, Avraham Borokovsky and Chava Langer went to the Tel Aviv Beit Din in order to execute a Get before Borokovsky’s second wedding. The Beit Din, while investigating the facts of the case, discovered Chava’s second marriage, and subsequently banned Otto and Chava from living together. Otto passed away in 1952. • IN 1955 When Chava seeked to remarry, the status of her children became known, and they were declared Mamzerim by the Beit Din. • This status was upheld until 1966, when Chanoch Langer, then a soldier in the IDF, approached Beit Din to get married. When the Beit Din ruled he was a Mamzer, he brought the case to the Supreme Rabbinical Court of Appeals. He argued that Avraham Borokovsky did not undergo a valid conversion and that he was still a practicing Christian. -
The Contemporary Jewish Legal Treatment of Depressive Disorders in Conflict with Halakha
t HaRofei LeShvurei Leiv: The Contemporary Jewish Legal Treatment of Depressive Disorders in Conflict with Halakha Senior Honors Thesis Presented to The Faculty of the School of Arts and Sciences Brandeis University Undergraduate Program in Near Eastern and Judaic Studies Prof. Reuven Kimelman, Advisor Prof. Zvi Zohar, Advisor In partial fulfillment of the requirements for the degree of Bachelor of Arts by Ezra Cohen December 2018 Accepted with Highest Honors Copyright by Ezra Cohen Committee Members Name: Prof. Reuven Kimelman Signature: ______________________ Name: Prof. Lynn Kaye Signature: ______________________ Name: Prof. Zvi Zohar Signature: ______________________ Table of Contents A Brief Word & Acknowledgments……………………………………………………………... iii Chapter I: Setting the Stage………………………………………………………………………. 1 a. Why This Thesis is Important Right Now………………………………………... 1 b. Defining Key Terms……………………………………………………………… 4 i. Defining Depression……………………………………………………… 5 ii. Defining Halakha…………………………………………………………. 9 c. A Short History of Depression in Halakhic Literature …………………………. 12 Chapter II: The Contemporary Legal Treatment of Depressive Disorders in Conflict with Halakha…………………………………………………………………………………………. 19 d. Depression & Music Therapy…………………………………………………… 19 e. Depression & Shabbat/Holidays………………………………………………… 28 f. Depression & Abortion…………………………………………………………. 38 g. Depression & Contraception……………………………………………………. 47 h. Depression & Romantic Relationships…………………………………………. 56 i. Depression & Prayer……………………………………………………………. 70 j. Depression & -
Neuropathophysiology, Genetic Profile, and Clinical Manifestation of Mucolipidosis IV—A Review and Case Series
International Journal of Molecular Sciences Review Neuropathophysiology, Genetic Profile, and Clinical Manifestation of Mucolipidosis IV—A Review and Case Series 1, 2, 3, , Aleksandra Jezela-Stanek y , El˙zbietaCiara y and Karolina M. Stepien * y 1 Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, 01-138 Warsaw, Poland; [email protected] 2 Department of Medical Genetics, The Children’s Memorial Heath Institute, 04-730 Warsaw, Poland; [email protected] 3 Adult Inherited Metabolic Diseases, Salford Royal NHS Foundation Trust, Salford M6 8HD, UK * Correspondence: [email protected] These authors contributed equally to this work. y Received: 31 May 2020; Accepted: 23 June 2020; Published: 26 June 2020 Abstract: Mucolipidosis type IV (MLIV) is an ultra-rare lysosomal storage disorder caused by biallelic mutations in MCOLN1 gene encoding the transient receptor potential channel mucolipin-1. So far, 35 pathogenic or likely pathogenic MLIV-related variants have been described. Clinical manifestations include severe intellectual disability, speech deficit, progressive visual impairment leading to blindness, and myopathy. The severity of the condition may vary, including less severe psychomotor delay and/or ocular findings. As no striking recognizable facial dysmorphism, skeletal anomalies, organomegaly, or lysosomal enzyme abnormalities in serum are common features of MLIV, the clinical diagnosis may be significantly improved because of characteristic ophthalmological anomalies. This review aims to outline the pathophysiology and genetic defects of this condition with a focus on the genotype–phenotype correlation amongst cases published in the literature. The authors will present their own clinical observations and long-term outcomes in adult MLIV cases. -
Electricity and Shabbat
5778 - bpipn mdxa` [email protected] 1 c‡qa HALACHIC AND HASHKAFIC ISSUES IN CONTEMPORARY SOCIETY 88 - ELECTRICITY & SHABBAT: PART 2 - MICROPHONES OU ISRAEL CENTER - SPRING 2018 A] THE HISTORICAL DEBATE 1878 Carbon microphone invented in the US. 1920 Significant development of microphone technology. 1940s R. Simcha Levy and the Halacha Commission for the RCA publish a decision permitting certain microphones on Shabbat and Yom Tov. 1951 Agudas HaRabbonim in the US issued a ruling prohibiting all use of microphones on Shabbat. 1954 Rav Soloveitchik spoke at the RCA conference against the use of microphones on Shabbat.1 c1970 Chief Rabbi of Israel, R. Isser Yehudah Unterman issued a psak permitting a use of a microphone on Shabbat within very specific guidelines.2 Rav Shaul Yisraeli3 issued a psak permitting certain microphones on Shabbat. c1995 Rav Yisrael Rozen of Zomet created the Zomet microphone. 1. SHABBAT MICROPHONES CATCHING ON AMONG ORTHODOX DESPITE TABOOS Jerusalem Post, May 5 2015 Ten years ago, the overflow crowd during the height of the summer season at Rabbi Marc Schneier’s synagogue in Westhampton Beach, New York, was so large it had to be housed in tents on the lawn outside. Acoustics were terrible, if not nonexistent, and many congregants decided to cease attending services because they felt disconnected from the activity inside. Turning to then-Israeli Chief Rabbi Yisrael Meir Lau and former Haifa Chief Rabbi She’ar Yashuv Cohen, Schneier was referred to Yisrael Rozen, a national-religious rabbi whose Zomet Institute in Alon Shvut had developed a Halacha- friendly sound system. Microphones, like the issue of separation of the sexes during prayers, had long been one of the dividing lines between Orthodox and Conservative congregations, with traditionalists shunning the technology as a violation of the legal norms regulating Shabbat observance. -
Politics of Exclusion in Judaism
Politics of Exclusion in Judaism Saul Lieberman and the Orthodox Part 3 In 1959 Lieberman became rector of the Seminary, and one of his responsibilities was "guiding the general religious policy of the institution." Thus, there is certainly justice in the assertion that, whatever his personal religious commitments, Lieberman had become part and parcel of the Conservative movement and was assisting it at the time that the Orthodox were attempting to expose what they regarded as the Conservative's distortions of halakha. Furthermore, there is no question that the leaders of Conservativism were able to use the presence of Lieberman at the Seminary to help legitimize the institution when it was challenged on religious grounds. For example, when Chief Rabbi Herzog came to New York he was willing to meet with some members of the Seminary faculty, but would not enter the building because Kaplan worked there. Finkelstein recalled telling Herzog, "It can't be as bad as you think if [Saul] Lieberman sits on the faculty." The presence of Kaplan at the Seminary was one of many problems mentioned in the following nasty letter Lieberman received: Dear Sir, For the sake of Parnasah and glory you have sold yourself to the Sitra Achra [the other side]. Do you not know that you are lending prestige to Mordecai Kaplan (Yimach Shemo) and to the other Kofrim at the Seminary, as well as to the graduates who are almost in every case M'gulche-Taar and Boale-Niddah? The United States has many Rabbinical Schools where honest young men are studying Torah and developing Talmide-Chachamim. -
Population Density Is Held Brake on Growth Easter
ESTABLISHED 1924 OFFICIAL NEWSPAPER JOF-THE TO WNSHIP AND SCHOOL DISTRICT OF HILLSIDE VOL. XLI, NO.-25 ■ THE HILLSIDE, TIMES, THURSDAY APRIL, 15, 1965 PRICE TEN CENTS PHONE 923-•9207 Progress In Cancer Fight Green Acres Aid For School Held Feasible - A special Greih-Acres Coni- Township. In- this respect, •mittee was formulated lastweek if certain arrangements as to By the Hillside Avenue School, the future' use of- th& Maplff’ '' w ............~ PTA, comprised of the follow- AVe, tract Were to be made"' tags - Mrs, Erwin Sehuman. whereby the Board of Eduoa. ■ principal; Dr, Wayne T, Bran- of the area for certain times om, Superintendent of Schools; of the day durlng- the year, Dr. HewyJ.Konzeiman, Chair-, This could' fall wlthtanto scope man , of the Home Owners Asso- of the Green Acres program.. clatldn; Mrs, Donald Glllmore, "Similar grants a re' being Mrs. Seymoqr'PollaA ansLMrs. arranged for nearby towns for. Richard Lacey. V property near a, school—and— A meeting Is s^meduled - successful arrangements are for Thursday April la at 8 P.M. being made for school use. at t o "Municipal Building when '"Currently,- -there - is' a ' tax-"-' t o eommittee will meet with :TeHef=hfli=pendtng=rhefsrezihjfc: M ayor Robe rt Di a mond, Mr. A1 - - -Assembly, recently passed by_ vin E. Gershen. Master t o Senate, grar.tlik municipal Planners representative, "and- ' tax rellef“ for -lands-taken by - Mr. Howard J. Wolf, Green the Green Acree program. The Acres Administrator, Depart- bill IS an- amendment to t o .nirmred are' workers forthe 1965 Hillside Cancer1 Crusade watching.Mflvnr Rnher-r Diamond sign ment of Goheegyattoh and '•Green Acres Act and It would a resolution marking the month of April Cancer.Month in hillside. -
MS-603: Rabbi Marc H. Tanenbaum Collection, 1945-1992
MS-603: Rabbi Marc H. Tanenbaum Collection, 1945-1992. Series C: lnterreligious Activities. 1952-1992 Box 19, Folder 4, Evangelism - Jewish reaction, 1972-1973. 3101 Clifton Ave, Cincinnati, Ohio 45220 (513) 221-1875 phone, (513) 221-7812 fax americanjewisharchives.org t . Saturday, Dec. 16, 1972 Philadelphia lnqi Jrer S I ' I Peril of Chri.stian Evangelism Cited by Jews Rabbi Says Conversions Can Destroy Existence of His People Christians seem to be get have the human effect or fate or America rests with the ting very possessive about destroying the existence of the success or failure of the cam Canada and the U. S. A. in Jewish people." paign. their Key 73 sloganeering The Nazis' massacre of the ANDREW WALLA CE . "Nothing in the Bible as· "Calling Our Continent to Jews and forced assimilation sures the U. S. of leadership Christ." of Jews in Russia have de On Religion in world affairs," he said. " A :'The part of the "continent" · strbyed two-thirds of the Jew nation unsure of who God is tii;ide up of those who would ish people, he said. soon gives itself over to raise ~~ther be called to Temple Jn view of that, "the whole gods and pays the penalty for are already more than a little Key 73, said "\ve have a question of efforts to convert that ambiguity." anxious about the implications commission to preach love to the Jewish ·people out of reli every creature. Our re cif· the massive evangelistic BOTH HE and Dr. Raedeke gious existence becomes (hrust of Christendom behind a sponsibility is to evangelize, said they felt the Jewish sen morally \mconscionable posi Ip bring the message to all . -
Consolidated Plate Glass (WESTERN) LIMITED the WINNIPEG SUPPLY & FUEL CO
Thursday, May 11, 1950 Thursday; May 11, 1950 THE JEWISH POST .-"~ ________________~P~a~g~e:S~~:~ THE JEWISH POST • Page Six - • EGYPT'S 2ND ROUND , I told him I might see him soon- in during the past year. Is the Z.O.C. and outspoken leaders such as the pealed to President Truman to per (Cont. from. page 3) Alexandria or umaybe Tel Aviv." going to degenerate to a mere fund late Rabbi Stephen Wise, Dr. Abba mit Israel to buy heavy armaments. FAURER PLANINOORPORATES GARDEN AREA IN , HOME A simular request was recently ;:::ircumstances. He laughed and said, "Perhaps we raising body? Are we going to fail Hillel Silver, Louis Lipsky, Henry Morg,{nthau Jr. and others? Let the turned down by Great Britain. On. A l~ttle group in grimy dungarees shall meet at Haifa." Israel in the hnportant field of pub April 13, Senator Herbert Lehman gathered around me. Using my lic relations and political action? Z.O.C. h1erarchy stand ).lp and be urged th.e United States to take the French-speaking friend as an inter WHITHER ZOC? Since Rabbi M a uri c e Pel'lzweig, counted! Israel needs your help now, lead in halting the re-armament of preter, I inquired if Egypt really (Cant. from page 3) former co-chairman of the Z.O.C. not tomorrmv. public relations committee left Can On February ,14, the Israeli gov the Arab states. He warned that the had a good navy. This question he are great possibilities for trade be ada a year ago, there has been little, ernment supplied data about Egyp Arabs are re-ar'ming for a "second answered himself, somewhat indig tween Canada and Israel which P if any, public reations activity. -
Medical Genetics Around the World Medical Genetics in Israel
J Med Genet: first published as 10.1136/jmg.26.3.179 on 1 March 1989. Downloaded from Medical genetics around the world Journal of Medical Genetics 1989, 26, 179-189 Medical genetics in Israel R M GOODMAN*t, B BONNE-TAMIRt, A ADAMt, R VOSS§**, G BACH§, Y SHILOHt, M BAT-MIRIAM KATZNELSON*t, G BARKAI*t, B GOLDMAN*t, B PADEH*t, J CHEMKE§1I, AND C LEGUMt¶ From *the Institute of Medical Genetics, The Chaim Sheba Hospital; tDepartment of Human Genetics, Sackler School of Medicine, Tel-Aviv University; JtDepartment of Biology, Everyman's University; WDepartment of Human Genetics, Hadassah University Hospital, Hebrew University; IKaplan Hospital, Rehovot; and ¶Ichilov Hospital, Tel-Aviv, Israel. When I was asked to write this article on human specific laws stating whom one can and cannot genetics in Israel, I was pleased to accept the marry. The Babylonian Talmud compiled approxi- challenge, but after pondering the subject for a mately 1500 years ago is an extremely rich source for period of time, I began to see some of the difficulties the description of a number of human genetic mal- in such an undertaking, owing to the great amoufnt formations and syndromes.' For example, various of investigative studies that has taken place in our cranial, facial, and body malformations are men- tioned in Kodashim, tractate Bekhorot 44a, familial country. My major concern was the unintentional copyright. omission of important historical information along epilepsy is described in Nashim, tractate Yevamot with scientific contributions to this broad and 64b, and in the same tractate and page one can find rapidly advancing field. -
Finding Utility for Genetic Diagnostics in the Developing World
Finding Utility for Genetic Diagnostics in the Developing World By Ridhi Tariyal B.S. Industrial Engineering, Georgia Institute of Technology (2002) M.B.A. Harvard Business School (2009) SUBMITTED TO THE HARVARD - MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREES OF MASTERS OF SCIENCE IN HEALTH SCIENCES AND TECHNOLOGY ARCHNES at the 4ASSACHUETFS ONS ITUTEj OF TFc, ooG MASSACHUSETTS INSTITUTE OF TECHNOLOGY MAR 9 1 2 11 September 2010 L @2010 Ridhi Tariyal. All rights reserved. IRARIES The author hereby grants MIT permission to reproduce and distribute publicly paper and electronic copies of thisthesis document in whole or in part. Signature of Author:"' H ard-MIT Division of Health $ciences and Technology, August 2010 Certified by: George Church Professor of Ge tics, Harvard Medical School, Director of the Center for Computational Genetics Thesis Supervisor Certified by: -Z-_==: - - Stan Lapidus Senior Lecturer, MIT Sloan School of Management Thesis Supervisor Accepted by: Ram Sasisekharan, PhD/Director, Harvard-MIT Division of Health Sciences and Technology/Edward Hood Taplin Professor of Health Sciences & Technology and Biological Engineering. ACKNOWLEDGEMENTS The idea behind this thesis was born in 2006 when I was working for a big pharmaceutical company and reading about the progress in genetics. I found myself spending more time thinking about the advances and challenges in the personalized medicine space than the immediate tasks and challenges in my employment. Since then, it has been a pleasure to move slowly but surely towards aligning my personal interests with my academic and professional pursuits. I would like to thank my classmates in school, my wonderful professors and my friends and family for brainstorming with me, encouraging me, answering endless questions about very personal genetic choices and offering unwavering support in this journey.