Publication List for Sharon A

PUBLICATION LIST FOR SHARON A. TOOZE UPDATED SEPTEMBER 2015 :

1. Lin, J. J.-C., and Queally, S. A. (1981), A monoclonal antibody that recognizes Golgi- associated protein of cultured fibroblast cells. Journal of Cell Biology, 92, 108-112. 2. Lin, J. J.-C., Burridge, K., Blose, S. H., Bushnell, A., Queally, S. A., and Feramisco, J.R. (1982), Cell and Muscle Motility, 2, 63-71, Ed. Robert M. Dowben and J.W. Shay, Plenum Publishing Corporation, New York. 3. Tooze, J., Tooze, S.A., and Warren, G.B. (1984), Replication of Coronavirus MHV-A59 in Sac(-) cells: determination of the first site of budding progeny virus. European Journal of Cell Biology, 33, 281-293. 4. Tooze, J., Tooze, S.A., and Warren, G.B. (1985), Laminated cisternae of the rough endoplasmic reticulum induced by Coronavirus MHV-A59 infection. European Journal of Cell Biology, 36, 108-115. 5. Tooze, J., and Tooze, S.A. (1985), A persistent infection of AtT20 murine pituitary tumor cells by Mouse Hepatitis Virus, strain A59. European Journal of Cell Biology, 37, 108-115. 6. Tooze, J. and Tooze, S.A. (1985), Infection of AtT20 murine pituitary tumour cells by mouse hepatitis virus strain A59: virus budding is restricted to the Golgi region. European Journal of Cell Biology, 37, 203-212. 7. Tooze, J., Tooze, S.A., Haisma, H., and Hilgers, J. (1985), AtT20 pituitary tumour cells contain mouse mammary tumour virus and intracisternal A-type particles in addition to murine leukemia virus. European Journal of Cell Biology, 39, 224-231. 8. Tooze, J. and Tooze, S.A. (1986), Clathrin-coated vesicular transport of secretory proteins during the formation of ACTH-containing secretory granules in AtT20 cells. Journal of Cell Biology, 103, 839-850. 9. Tooze, S.A., and Stanley, K.K. (1986), Identification of two epitopes in the carboxyterminal 15 amino acids of the E1 glycoprotein of Mouse Hepatitis Virus A59 by using hybrid proteins. Journal of Virology, 60, 928-934. 10. Tooze, J., Tooze, S.A., Fuller, S.D. (1987), Sorting of progeny coronavirus from condensed secretory proteins at the exit from the trans-Golgi network of AtT20 cells. Journal of Cell Biology, 105, 1215-1226. 11. Tooze, S.A., Tooze, J., and Warren, G.B. (1988), Site of addition of N -acetyl- galactosamine to the E1 glycoprotein of Mouse Hepatitis Virus-A59. Journal of Cell Biology, 106, 1475-1487. 12. Tooze, J., Hollinshead, M., Fuller, S.D., Tooze, S.A., and Huttner, W.B. (1989), Morphological and biochemical evidence showing neuronal properties in AtT20 cells and their growth cones. European Journal of Cell Biology, 49, 259-273. 13. Huttner, W.B. and Tooze, S.A. (1989), Biosynthetic protein transport in the secretory pathway, Current Opinion in Cell Biology, 1, 648-654. 14. Tooze, S.A., and Huttner, W.B. (1990), Cell-free protein sorting to the regulated and constitutive pathways. Cell, 60, 837-847. 15. Tooze, S.A., Weiss, U., and Huttner, W.B. (1990), Requirement for GTP hydrolysis in the formation of secretory vesicles. Nature, 347, 207-208. 16. Régnier-Vigouroux, A., Tooze, S.A. and Huttner, W.B. (1991), Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane. EMBO Journal, 10, 3589-3601. 17. Barr, F., Leyte, A., Mollner. S., Pfeuffer, T., Tooze, S.A., and Huttner, W.B. (1991), Trimeric G-proteins are involved in the formation of constitutive secretory vesicles and immature secretory vesicles. FEBS Letters, 294, 239-243. 18. Tooze, S.A. (1991), Biogenesis of secretory granules. Implications arising from the immature secretory granule in the regulated pathway of secretion. FEBS Letters, 285, 220- 224. 19. Tooze, S.A., Flatmark, T., Tooze, J. and Huttner, W.B. (1991), Characterization of the immature secretory granule, an intermediate in the biogenesis of secretory granules. Journal of Cell Biology, 115, 1491-1503. 2

20. Tooze, S.A. and J.C. Stinchcombe, (1992), Biogenesis of secretory granules. Seminars in Cell Biology, 3, 357 - 366. 21. Tooze, S.A. and W.B. Huttner, (1992), "Cell-free formation of immature secretory granules and constitutive secretory vesicles from the trans-Golgi network", in Reconstitution of Intracellular Protein Transport, Methods in Enzymology, 219, 81-93, Ed. J. Rothman, Academic Press, New York. 22. Chanat, E., Weiss, U., Huttner, W.B., and Tooze, S.A. (1993), Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans -Golgi network causes its missorting to the constitutive secretory pathway. EMBO Journal, 12, 2159 - 2168. 23. Urbé, S., Huber, L.A., Zerial, M., Tooze, S.A., and Parton, R.G. (1993), Rab11, a small GTPase associated with both constitutive regulated secretory pathways in PC12 cells. FEBS Letters, 334, 175-182. 24. Leyte, A., Barr, F.A., Tooze, S.A., and Huttner, W.B. (1993), "GTP-binding proteins and the formation of secretory vesicles" in Signal Transduction during Biomembrane fusion, 147 - 162, Ed. D.H. O'Day, Academic press, New York. 25. Tooze, S.A., Chanat, E., Tooze, J., and Huttner, W.B. (1993), "Secretory granule formation", in Mechanisms of Intracellular trafficking and processing of Pro-proteins, 157 - 178, Ed. Y. Peng Loh, CRC Press, Florida. 26. Huttner, W.B., Barr, F.A., Bauerfeind, R., Bräuling, O., Chanat, E., Leyte, A., Ohashi, M., Régnier-Vigouroux, A., Flatmark, T., Gerdes, H.-H., Rosa, P., and Tooze, S.A. (1993), "Biogenesis of Neurosecretory Vesicles" in Glyco- and Cell Biology, pp. 53-59, Springer- Verlag, Heidelberg. 27. Tooze, S.A., Hollinshead, M., Dittié, A.S. (1994), Antibodies to Secretogranin II reveal potential processing sites. Biochemie, 76, 271-276. 28. Dittié, A.S., and Tooze, S.A. (1995), Characterization of the endopeptidase PC2 activity towards secretogranin II in stably transfected PC12 cells. Biochemical Journal, 310, 777- 787. 29. Dittié, A.S., Hajibagheri, N, and Tooze, S.A. (1996), The AP-1 adaptor complex binds to immature secretory granules from PC12 cells, and is regulated by ADP-ribosylation factor. Journal of Cell Biology, 132, 523-536. 30. Seethaler, G, Tooze, S.A. and Shields, D. (1996), Fusion and confusion in the secretory pathway, Trends in Cell Biology, 6, 239-242. 31. Urbé, S., Dittié, A.S., and Tooze, S.A. (1997), pH-dependent processing of secretogranin II by the endopeptidase pc2 in isolated immature secretory granules. Biochemical Journal, 321, 65-74. 32. Urbé, S., Tooze, S.A. and Barr, F. (1997), Formation of secretory vesicles in the biosynthetic pathway, Biochimica et Biophysica Acta, 1358/1, 6-22. 33. Dittié, A.S., Thomas, L., Thomas, G., and Tooze, S.A. (1997), Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation. EMBO Journal, 16, 4859-4870. 34. Laslop, A., Weiss, C., Savaria, D., Eiter, C., Tooze, S.A., Sediah, N.G. and Winkler, H. (1998), Proteolytic processing of chromogranin B and secretogranin II by prohormone convertases. Journal of Neurochemistry, 70, 374-383. 35. Tooze, S. A., Seethaler, G., Shields, D. (1998), The slippery slopes of secretion, Trends in Cell Biology, 8, 211-213. 36. Chanat, E., Dittié, A.S., Tooze, S.A. (1998), Analysis of the sorting of secretory proteins to the regulated secretory pathway. In Methods in Molecular Biology, Vol. 88, pp. 285 – 324, Humana Press, New Jersey. 37. Tooze, S.A. (1998), The role of the Golgi in the biogenesis of secretory granules in neuroendocrine and endocrine cells, Biochimica et Biophysica Acta, 1404, 231-244. 38. Urbé, S., Page, L.J., Tooze, S.A. (1998), Homotypic fusion of immature secretory granules during maturation in a cell-free assay. Journal of Cell Biology, 143, 1831-1844. 39. Tooze, S.A. (1999) “Metabolic labelling with [35S]-sulfate”. Current Protocols in Cell Biology, ed. J. Bonifacino, pp. 7.3.1 – 7.3.7, John Wiley & Sons, Inc. 3

40. Dittié, A.S., Klumperman, J., Tooze, S.A. (1999), Differential distribution of mannose-6- phosphate receptors and furin in immature secretory granules. Journal of Cell Science, 112, 3955-3966. 41. Pauloin, A., Tooze, S.A., Michelutti, I., Delpal, S., Ollivier-Bousquet, M. (1999), The majority of clathrin coated vesicles from lactating mammary gland arises from the secretory pathway. Journal of Cell Science, 112, 4089-4100. 42. Molinete, M., Irminger, J.-C., Tooze, S.A. and Halban, P.A. (2000), Trafficking/sorting and granule biogenesis in the b-cell, Seminars in Cell and Developmental Biology, 11, 243- 251. 43. Schoonderwoert, V.T.G., Holtius, J.C.M., Tanaka, S., Tooze, S.A., Martens, G.J.M. (2000), Inhibition of the vacuolar H+-ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins. European Journal of Biochemistry, 267, 5646-5654. 44. Austin, C., Hinners, I. and Tooze, S.A (2000), Direct and GTP-dependent interaction of ADP-ribosylation factor 1 with clathrin adaptor protein, AP-1, on immature secretory granules. Journal of Biological Chemistry, 275, 21862-21869. 45. Tooze, S.A. (2001), Autophagy in the test tube, ELSO Gazette, January 2001. 46. Tooze, S.A., Martens, G.J.M, Huttner, W.B. (2001) Secretory granule biogenesis: Rafting to the SNARE, Trends in Cell Biology, 11, 116-122. 47. Tooze, S.A., Seethaler, G. Shields, D. (2001) The Art of Protein Sorting, Traffic, 2:358- 361. 48. Tooze, S.A. (2001) GGAs tie up the loose ends, Science, 292, 1663-1665. 49. Wendler, F., Page, L., Urbé, S., Tooze, S.A. (2001), Homotypic fusion of immature secretory granules during maturation requires syntaxin 6. Molecular Biology of the Cell, 12:1699-1709. 50. Crump, C.M., Xiang, Y., Thomas, L., Austin, C., Tooze, S.A., Thomas, G. (2001) PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. EMBO Journal, 20, 2191-2201. 51. Austin, C.A., Boehm, M., Tooze, S.A. (2002) Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with Adaptor protein complexes-1 and 3. Biochemistry, 41, 4669-4677. 52. Panaretou, C., and Tooze, S.A. (2002) Regulation and recruitment of Phosphatidylinositol 4-kinase on immature secretory granules is independent of ADP- ribosylation Factor 1. Biochemical Journal, 363, 289-295. 53. Hinners, I., and Tooze, S.A. (2003) Changing directions: clathrin mediated transport between Golgi and endosomes. Journal of Cell Science, 116, 763-771. 54. Alberts, P., Rudge, R., Hinners, I., Muzerelle, A. Martinez-Arca, S., Irinopoulou, T., Marthiens, V., Tooze, S.A., Rathjen, F., Gaspar, P. and Galli, T. (2003) Cross Talk between Tetanus Neurotoxin-insensitive Vesicle-associated Membrane Protein-mediated Transport and L1-mediated Adhesion. Molecular Biology of the Cell, 14: 4207-4220. 55. Hinners, I., Wendler, F., Fei, H., Thomas, L., Thomas, G., and Tooze, S.A. (2003) AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1. EMBO Reports, 4:1182-1189. 56. Koechl, R., Hu, X.W., Chan, E., and Tooze, S.A. (2006) Microtubules facilitate autophagosome formation and are essential for fusion of autophagosomes with endosomes. Traffic, 7:129-139. 57. Chan, E.Y.W., Koechl, R., and Tooze S.A. (2006) “Cell biology and Biochemistry of Autophagy”, in Autophagy in Immunity and Infection, Ed. Vojo Deretic, Wiley-VCH. 58. Kakhlon, O., Sakya, P., Larijani, B., and Tooze, S.A. (2006) Dominant negative GGA inhibits membrane remodeling and substrate processing in maturing neuroendocrine secretory granules. EMBO Journal, 25:1590-1602. 59. Ahras, M., Otto, G.P., and Tooze, S.A. (2006) Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells. Journal of Cell Biology, 173:241-252. 60. Young, A., Chan, E.Y.W., Hu, X. W., Köchl, R., Cranshaw, S.G., High, S., Haley, D., Lippincott-Schwartz, J., Tooze, S.A. (2006) Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes. Journal of Cell Science, 119:3888- 3900. 4

61. Webber, J., Young A., Tooze, S.A. (2007) Atg9 Trafficking in Mammalian Cells. Autophagy, 3: 54-56. 62. Chan, E. Y. W., Kir, S., and Tooze, S.A. (2007) siRNA screening of the kinome identifies ULK1 as a multi-domain modulator of autophagy. Journal of Biological Chemistry, 282:25464-25474. 63. Morvan, J. and Tooze, S.A. (2008) Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cells. Histochemistry and Cell Biology, 129:243-252. 64. Klionsky, D.J., (followed by 218 authors), Tooze, S.A. (followed by 25 authors) and Deter, R.L. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 4:151-175. 65. Young, A. and Tooze, S.A. (2008) “Protein Trafficking to Autophagosomes” in Methods in Molecular Biology, Humana Press Inc. 445:147-157. 66. Tooze, S.A., Schiavo, G. (2008) Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration. Current Opinions in Neurobiology, 18:504-15. 67. Chan, E.Y.W., Longatti, A., McKnight, N.C., Tooze, S.A. (2009) Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domain using an Atg13-independent mechanism. Molecular and Cellular Biology, 29:157-171. 68. Razi, M., and Tooze, S.A. (2009) Correlative light and Electron Microscopy, in, Methods in Enzymology, Vol. 452, pp 261-75, Autophagy in Mammalian Systems in press, Ed. D. Klionsky, Academic Press, New York. 69. Razi, M., Chan, E.Y.W., Tooze, S.A. (2009) Early Endosomes and Endosomal Coatomer are required for Autophagy. Journal of Cell Biology, 185:305-321. 70. Longatti, A. and Tooze, S.A. (2009) Vesicular trafficking and autophagosome formation. Cell Death and Differentiation, 16:956-965. 71. Morvan, J., Köchl, R., Watson, R., Lucy M. Collinson, L.M., Jefferies, H.B.J., Tooze, S.A. (2009) In vitro reconstitution of fusion between Immature Autophagosomes and Endosomes. Autophagy, 5: 676-689. 72. de Lartigue, J., Polson, H., Feldman, M., Shokat, K., Tooze, S.A., Urbé, S. Clague, M.J. (2009) PIKfyve regulation of endosome-linked pathways. Traffic, 10:883-893. 73. Chan, E.Y. W., and Tooze, S.A. (2009) Evolution and Expansion of Atg1 Function. Autophagy, 5:758-765. 74. Tooze, S.A., and Razi, M. (2009) The essential role of early endosomes in autophagy is revealed by loss of COPI function. Autophagy 5:874-875. 75. Simonsen, A., and Tooze, S.A. (2009) Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. Journal of Cell Biology, 186:773-782. 76. Reggiori F., and Tooze, S.A. (2009) The EmERgence of autophagosomes. Developmental Cell, 17:747-748. 77. Webber, J.L. and Tooze, S.A. (2010) Co-ordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP. EMBO Journal, 29:27-40. 78. Orsi, A., Polson, H.E., Tooze, S.A. (2010) Membrane trafficking events that partake in autophagy. Current Opinion in Cell Biology, 22:150-156. 79. Webber, J.L. and Tooze, S.A. (2010) New insights into the function of mammalian Atg9. FEBS Letters, 584:1319-1326. 80. Otto, G.P., Razi, M., Morvan, J., Stenner, F. and Tooze, S.A. (2010) A novel Syntaxin 6-interacting protein, SHIP164, regulates Syntaxin 6-dependent sorting from early endosomes. Traffic, 11:688-705. 81. Tooze, S.A. (2010) The role of membrane proteins in mammalian autophagy. Seminars in Cell and Developmental Biology, 21:677-82. 82. Klionsky, D.J., Codogno, P., Cuervo, A.M. Deretic, V., Elazar, Z., Fueyo-Margareto, J., Gewirtz, D.A., Kroemer, G., Levine, B., Mizushima, N., Rubinsztein, D.C., Michael Thumm. M., and Tooze, S.A. (2010) A comprehensive glossary of autophagy-related molecules and processes. Autophagy, 6:438-448. 83. Polson, H.E.J., de Lartigue, J., Rigden, D.J., Reedijk, M., Urbé, S., Clague, M.J. and Tooze, S.A. (2010) Mammalian Atg18 (WIPI2) localises to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy, 6: 506-522. 5

84. Tooze, S.A. Jefferies, H.B., Kalie, E., Longatti, A., McAlpine, F.E., McKnight, N.C., Orsi, A., Polson, H.E., Razi, M., Robinson, D.J., Webber, J.L. (2010) Trafficking and signaling in mammalian autophagy. IUBMB Life, 62: 503-508. 85. Tooze, S.A., Yoshimori, T. (2010) The origin of the autophagosomal membrane. Nature Cell Biology, 12:831-835. 86. Longatti, A., Orsi, A., Tooze, S.A. (2010) Autophagosome formation: not necessarily an inside job. Cell Research, 20:1181-1184. 87. Klionsky, D.J., Baehrecke, E.H., Brumell, J.H., Chu, C.T., Codogno, P., Cuervo, A.M., Debnath, J., Deretic, V., Elazar, Z., Eskelinen, E.-L., Finkbeiner, S., Fueyo-Margareto, J., Gewirtz, D., Jäättelä, M., Kroemer, G., Levine, B., Melia, T.J., Mizushima, N., Rubinsztein, D.C., Simonsen, A., Thorburn, A., Thumm, M. and Tooze, S.A. (2010) A comprehensive glossary of autophagy-related molecules and processes. Autophagy, 7:1273-1294. 88. Tooze S.A., Codogno P. (2011) Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2. EMBO Journal, 30:1185-6. 89. Lee, A.J., Roylance, R., Sander, J., Gorman, P., Endesfelder, D., Kschischo, M., Jones, N.P., East, P., Nicke, B., Spassieva, S., Obeid, L.M., Juul Birkbak, N., Szallasi, Z., McKnight, N.C., Rowan, A.J., Speirs, V., Hanby, A.M., Downward, J., Tooze, S.A., Swanton, C. (2011) CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction. Journal of Pathology, 226:482-494. 90. Klionsky, D.J., Baehrecke, E.H., Brumell, J.H., Chu, C.T., Codogno, P., Cuervo, A.M., Debnath, J., Deretic, V., Elazar, Z., Eskelinen, E.L., Finkbeiner, S., Fueyo-Margareto, J., Gewirtz, D., Jäättelä, M., Kroemer, G., Levine, B., Melia, T.J., Mizushima, N., Rubinsztein, D.C., Simonsen, A., Thorburn, A., Thumm, M., Tooze, S.A. (2011) A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy, 7:1273-94. 91. Deselm, C.J., Miller, B.C., Zou, W., Beatty, W.L., van Meel, H., Takahata, Y., Klumperman. J., Tooze, S.A., Teitelbaum, S.L., Virgin, H.W. (2011) Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption. Developmental Cell, 21:966-974. 92. Mari, M., Tooze, S.A., Reggiori, F. (2011) The puzzling origin of the autophagosomal membrane. F1000 Biology Reports, 3:25. 93. Kalie, E., Tooze, S.A. (2012) Tales of the autophagy crusaders. EMBO Reports, 13:175-177. 95. McKnight, N.C., McKnight, N. C., Jefferies, H.B.J., Alemu, E.A., Saunders, R.E., Howell, M., Johansen, T., Tooze, S.A. (2012) Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. EMBO Journal, 31:1931-1946. 96. Orsi, A., Razi, M., Robinson, D., Weston, A.E., Collinson, L.M., Dooley, H., Tooze, S.A. (2012) Dynamic interactions of Atg9 with early autophagosome precursors, but not membrane integration, is required for autophagy. Molecular Biology of the Cell, 23:1860-1873. 97. Longatti, A., Lamb, C.A., Razi, M., Yoshimura, S.-I., Barr, F. A., Tooze, S.A. (2012) TBC1D14 regulates autophagosome formation via Rab11 and ULK1-positive recycling endosomes. Journal of Cell Biology, 197:659-675. 98. Reggiori, F., Tooze, S.A. (2012) Autophagy regulation through Atg9 traffic. Journal of Cell Biology, 198:151-153. 99. Klionsky, D.J., et al, Tooze, S.A. et al (1267 other authors) (2012) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 8:445-544. 100. Joachim, J., Wirth, M., McKnight, N.C., Tooze, S.A. (2012) Coiling up with SCOC and WAC: Two new regulators of starvation-induced autophagy. Autophagy, 8:1397-1400. 101. Kraft, C., Kijanska, M., Kalie, E., Siergiejuk, E., Lee, S.S., Semplicio, G., Stoffel, I., Brezovich, A., Verma, M., Hansmann, I., Ammerer, G., Hofmann, K., Tooze, S. A., Peter, M. (2012) Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy. EMBO Journal, 31:3691-3703. 102. Longatti, A., Tooze, S.A. (2012) Recycling endosomes contribute to autophagosome formation. Autophagy, 11:1682-1683. 103. Stanley P, Tooze S, Hogg N. (2012) A role for Rap2 in recycling the extended conformation of LFA-1 during T cell migration. Biology Open, 1:1161-1168. 6

104. Mleczak, A., Millar, S., Tooze, S.A., Olson, M.F., Chan, E.Y. (2013). Regulation of autophagosome formation by Rho kinase. Cellular Signalling, 25:1-11. 105. Lamb, C.A., Dooley, H.C., Tooze, S.A. (2013) Endocytosis and autophagy: Shared machinery for degradation. Bioessays, 35:34-45. 106. McAlpine, F., Williamson, L.E., Tooze, S.A. and Chan, Y.W. (2013) Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2. Autophagy, 9:361- 373. 107. Ktistakis, N.T. and Tooze, S.A. (2013) PIPing on lysosome tubes. EMBO Journal, 32:315-317. 108. Shoji-Kawata, S., Sumpter, R., Leveno, M., Campbell, G.R., Zou, Z., Kinch, L., Wilkins, A.D., Sun, Q., Pallauf, K., MacDuff, D., Huerta, C., Virgin, H.W., Helms, J.B., Eerland, R., Tooze, S.A., Xavier, R., Lenschow, D.J., Yamamoto, A., King, D., Lichtarge, O., Grishin, N.V., Spector, S.A., Kaloyanova, D.V., Levine, B. (2013) Identification of a candidate therapeutic autophagy-inducing peptide. Nature, 494:201-206. 109. Kögel, T., Rudolf, R., Hodneland, E., Copier, J., Regazzi, R., Tooze, S.A., Gerdes, H.H. (2013) Rab3D Is Critical for Secretory Granule Maturation in PC12 Cells. PLoS One. 2013;8(3):e57321. 110. Manzoni, C., Mamais, M., Dihanich, S., Abeti, R., Soutar, M.P., Plun-Favreau, H., Giunti, P., Tooze, S.A., Bandopadhyay, R., Lewis. P. (2013) Inhibition of LRRK2 kinase activity stimulates macroautophagy. BBA - Molecular Cell Research, in press. 111. Kalie, E., Razi, M. and Tooze, S.A. (2013) ULK1 regulates melanin levels in MNT-1 cells independently of mTORC1. PLoS One. 2013;8(9):e75313. 112. Tooze, S.A. (2013) Current Views on the source of the autophagosome membrane. Essays in Biochemistry 55:29-38. 113. Wirth, M., Joachim, J., Tooze S.A. (2013) Autophagosome formation-The role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage. Seminars in Cancer Biology, 23:301-309. 114. Tattoli, I., Sorbara, M.T., Yang, C., Tooze, S.A., Philpott, D.J., Girardin, S.E. (2013) Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures. EMBO J. 2013 32(23):3066-78. doi: 10.1038/emboj.2013.234. Epub 2013 Oct 25. 115. Duke, E.M., Razi, M., Weston, A., Guttmann, P., Werner, S., Henzler, K., Schneider, G., Tooze, S.A., Collinson, L.M. (2013) Imaging endosomes and autophagosomes in whole mammalian cells using correlative cryo-fluorescence and cryo-soft X-ray microscopy (cryo- CLXM). Ultramicroscopy. Oct 21. pii: S0304-3991(13)00281-7. doi: 10.1016/j.ultramic.2013.10.006. 116. Manzoni, C., Mamais, A., Dihanich, S., McGoldrick, P., Devine, M.J., Zerle, J., Kara, E., Taanman, J.W., Healy, D.G., Marti-Masso, J.F., Schapira, A.H., Plun-Favreau, H., Tooze, S., Hardy, J., Bandopadhyay, R., Lewis, P.A. (2013) Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochem Biophys Res Commun. 441: 862-866. doi: 10.1016/j.bbrc.2013.10.159. 117. Lamb, C.A., Yoshimori, T., Tooze, S.A. (2013) The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol. 14:759-774. doi: 10.1038/nrm3696. 118. Ellis, R.A., Horswell, S., Ness, T., Lumsdon, J., Tooze, S.A., Kirkham, N., Armstrong, J.L., Lovat, P.E. (2014) Prognostic Impact of p62 Expression in Cutaneous Malignant Melanoma. J Investigative Dermatology. doi: 10.1038/jid.2013.497. 119. Talaber, G., Miklossy, G., Oaks Z, Liu, Y., Tooze S.A., Chudakov DM, Banki K, Perl A. (2014) HRES-1/Rab4 promotes the formation of LC3(+) autophagosomes and the accumulation of mitochondria during autophagy. PLoS One. 2014 Jan 3;9(1):e84392. doi: 10.1371/journal.pone.0084392. 120. Tooze, S.A., Abada, A., Elazar, Z. (2014) Endocytosis and autophagy: exploitation or cooperation? Cold Spring Harbor Perspectives in Biology. 6(5). pii: a018358. doi: 10.1101/cshperspect.a018358. 121. Dooley, H.C., Razi, M., Polson, H.E.J., Stephen E. Girardin, S.E., Michael I. Wilson, M.I., Tooze, S.A. (2014) WIPI2 Links LC3-Conjugation with PI3P, Autophagosome Formation and Pathogen Clearance by Recruiting Atg12–5-16L1. Molecular Cell, 55:238-52. doi: 10.1016/j.molcel.2014.05.021. 7

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